Research
Systematic reviews of therapeutic interventions for advanced cancers
Cochrane systematic reviews
1. Chemoradiation for locally advanced cervical cancer
2. Pemetrexed in combination with cisplatin in advanced mesothelioma
3. First line therapy for EGFR mutated non-small cell lung cancer
Phase 1 and 2 studies of novel anticancer agents
Phase 1b/11 study of APR-246 in combination with chemotherapy in platinum sensitive relapsed high grade serous ovarian cancer
This novel agent has 2 anticancer actions - firstly it reverses the unfolding of the tumour suppressor p53 and secondly it reduces glutathione levels and inhibits thioredoxin reductase. Both mechanisms may be relevant to targeting tumours with p53 alterations, detected in over 50% of human cancers, by promoting apoptosis. Secondly enhancing sensitivity to cytotoxic agents including cisplatin and radiation by altering the REDOX status of the cell.
Targeting invasion in ovarian cancer
Collaboration with Dr Daimark Bennett in Life Sciences in translation of invasion model systems based on the Drosophila ovary and cell line systems
Research grants
Molecular markers of prognosis in ovarian cancer though analysis of the EORTC/NCRI randomised phase III study of platinum/taxane chemotherapy ± erlotinib.
CANCER RESEARCH UK (UK)
April 2007 - September 2010
Ovplex
HEALTHLINX LIMITED (AUSTRALIA)
July 2010 - March 2012
OVO7.
CANCER RESEARCH UK (UK)
January 2006 - June 2010
Dr S L Lim Fellowship.
CLATTERBRIDGE CANCER RESEARCH
February 2006 - January 2007
Randomised Phase III Trial of Paclitaxel plus Carboplatin Therapy versus Irinotecan plus Cisplatin therapy as a First Line Chemotherapy for Clear Cell Carcinoma of the Ovary
CANCER RESEARCH UK (UK)
January 2010 - December 2012
To investigate the diagnostic and prognostic utility of MIPs in endometrial cancer
THE HIGHER COMMITTEE FOR EDUCATION DEVELOPMENT IN IRAQ (HCED) (IRAQ)
September 2012 - September 2016
Translational research in clear cell cancer of the ovary: CCC-1TRANS
CANCER RESEARCH UK (UK)
January 2010 - December 2013
The role and regulation of TOR signalling networks in ovarian cancer metastasis
NORTH WEST CANCER RESEARCH FUND
January 2013 - June 2015
Research collaborations
Prof D Fernig
Translational studies in ovarian cancer related to clinical trial
Professor H Rees
Collaboration on serum proteomics project in ovarian cancer