Publications
2023
SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response
Bland, P., Saville, H., Wai, P. T., Curnow, L., Muirhead, G., Nieminuszczy, J., . . . Natrajan, R. (2023). SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response. NATURE GENETICS, 55(8), 1311-+. doi:10.1038/s41588-023-01460-5
Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target
Groenewoud, A., Yin, J., Gelmi, M. C., Alsafadi, S., Nemati, F., Decaudin, D., . . . Snaar-Jagalska, B. E. (2023). Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target. CELL DEATH DISCOVERY, 9(1). doi:10.1038/s41420-023-01446-6
Novel prognostication biomarker adipophilin reveals a metabolic shift in uveal melanoma and new therapeutic opportunities
Matareed, M., Maranou, E., Koskela, S. A., Mehmood, A., Kalirai, H., Coupland, S. E., & Figueiredo, C. R. (2023). Novel prognostication biomarker adipophilin reveals a metabolic shift in uveal melanoma and new therapeutic opportunities. JOURNAL OF PATHOLOGY. doi:10.1002/path.6076
Sensitivity and Specificity of Different Prognostic Systems in Guiding Surveillance for Metastases in Uveal Melanoma
Robinson, H., Eleuteri, A., Sacco, J. J., Hussain, R., Heimann, H., Taktak, A. F. G., . . . Coupland, S. E. (2023). Sensitivity and Specificity of Different Prognostic Systems in Guiding Surveillance for Metastases in Uveal Melanoma. CANCERS, 15(9). doi:10.3390/cancers15092610
Zebrafish Patient-Derived Xenograft Model as a Preclinical Platform for Uveal Melanoma Drug Discovery
Yin, J., Zhao, G., Kalirai, H., Coupland, S. E., Jochemsen, A. G., Forn-Cuni, G., . . . Groenewoud, A. (2023). Zebrafish Patient-Derived Xenograft Model as a Preclinical Platform for Uveal Melanoma Drug Discovery. PHARMACEUTICALS, 16(4). doi:10.3390/ph16040598
Using the Chick Embryo Model to Examine the Effects of Hypoxia Pre-conditioning of Uveal Melanoma Cellson Tumor Growth and Metastasis (vol 48, pg 408, 2023)
Draper, J., Alexander, J., Nair, R. M., Scullion, N., Narayana, R. V. L., Aughton, K., . . . Coupland, S. E. (2023). Using the Chick Embryo Model to Examine the Effects of Hypoxia Pre-conditioning of Uveal Melanoma Cellson Tumor Growth and Metastasis (vol 48, pg 408, 2023). CURRENT EYE RESEARCH. doi:10.1080/02713683.2023.2192394
2022
Investigating the Role of DUSP4 in Uveal Melanoma.
Aughton, K., Sabat-Pospiech, D., Barlow, S., Coupland, S. E., & Kalirai, H. (2022). Investigating the Role of DUSP4 in Uveal Melanoma.. Translational vision science & technology, 11(12), 13. doi:10.1167/tvst.11.12.13
Using the Chick Embryo Model to Examine the Effects of Hypoxia Pre-conditioning of Uveal Melanoma Cells on Tumor Growth and Metastasis
Draper, J., Alexander, J., Nair, R. M. M., Scullion, N., Narayana, R. V. L., Aughton, K., . . . Coupland, S. E. E. (2022). Using the Chick Embryo Model to Examine the Effects of Hypoxia Pre-conditioning of Uveal Melanoma Cells on Tumor Growth and Metastasis. CURRENT EYE RESEARCH. doi:10.1080/02713683.2022.2152055
Aggressive uveal melanoma displays a high degree of centrosome amplification, opening the door to therapeutic intervention
Sabat-Pospiech, D., Fabian-Kolpanowicz, K., Kalirai, H., Kipling, N., Coupland, S. E., Coulson, J. M., & Fielding, A. B. (2022). Aggressive uveal melanoma displays a high degree of centrosome amplification, opening the door to therapeutic intervention. JOURNAL OF PATHOLOGY CLINICAL RESEARCH, 8(4), 383-394. doi:10.1002/cjp2.272
Re: Gelmi et al.: Adding The Cancer Genome Atlas Chromosome Classes to American Joint Committee on Cancer System offers more precise prognostication in uveal melanoma (Ophthalmology. 2022:129:431-437)
Coupland, S., Kalirai, H., Taktak, A., Eleuteri, A., & Damato, B. (2022). Re: Gelmi et al.: Adding The Cancer Genome Atlas Chromosome Classes to American Joint Committee on Cancer System offers more precise prognostication in uveal melanoma (Ophthalmology. 2022:129:431-437). OPHTHALMOLOGY, 129(7), E78-+. Retrieved from https://www.webofscience.com/
A Retrospective Analysis of 10 Years of Liver Surveillance Undertaken in Uveal Melanoma Patients Treated at the Supraregional "Liverpool Ocular Oncology Centre", UK
Rola, A. C., Kalirai, H., Taktak, A. F. G., Eleuteri, A., Krishna, Y., Hussain, R., . . . Coupland, S. E. (2022). A Retrospective Analysis of 10 Years of Liver Surveillance Undertaken in Uveal Melanoma Patients Treated at the Supraregional "Liverpool Ocular Oncology Centre", UK. CANCERS, 14(9). doi:10.3390/cancers14092187
Erratum in: Carboplatin- and Etoposide-Loaded Lactoferrin Protein Nanoparticles for Targeting Cancer Stem Cells in Retinoblastoma In Vitro" (vol 62, 13, 2021)
Narayana, R. V. L., Jana, P., Tomar, N., Prabhu, V., Nair, R. M., Manukonda, R., . . . Vemuganti, G. K. (2022). Erratum in: Carboplatin- and Etoposide-Loaded Lactoferrin Protein Nanoparticles for Targeting Cancer Stem Cells in Retinoblastoma In Vitro" (vol 62, 13, 2021). INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 63(4). doi:10.1167/iovs.63.4.16
Vascular Lakes in Uveal Melanoma and Their Association With Outcome.
Jones, H., Kalirai, H., Taktak, A., Chen, K., & Coupland, S. E. (2022). Vascular Lakes in Uveal Melanoma and Their Association With Outcome.. Translational vision science & technology, 11(3), 32. doi:10.1167/tvst.11.3.32
Integrative omics approach identifies druggable BAP1-dependencies in Uveal Melanoma
Silva, L., Barnett, S., Kenyani, J., Butt, Z., Aughton, K., Hammond, D., . . . Coulson, J. (2022). Integrative omics approach identifies druggable BAP1-dependencies in Uveal Melanoma. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 63. Retrieved from https://www.webofscience.com/
Re: Gelmi et al.: Adding The Cancer Genome Atlas Chromosome Classes to American Joint Committee on Cancer System offers more precise prognostication in uveal melanoma (Ophthalmology. 2022:129:431-437)
Coupland, S., Kalirai, H., Taktak, A., Eleuteri, A., & Damato, B. (2022). Re: Gelmi et al.: Adding The Cancer Genome Atlas Chromosome Classes to American Joint Committee on Cancer System offers more precise prognostication in uveal melanoma (Ophthalmology. 2022:129:431-437). OPHTHALMOLOGY, 129(7), E78-E79. Retrieved from https://www.webofscience.com/
2021
Carboplatin- and Etoposide-Loaded Lactoferrin Protein Nanoparticles for Targeting Cancer Stem Cells in Retinoblastoma In Vitro
Narayana, R. V. L., Jana, P., Tomar, N., Prabhu, V., Nair, R. M., Manukonda, R., . . . Vemuganti, G. K. (2021). Carboplatin- and Etoposide-Loaded Lactoferrin Protein Nanoparticles for Targeting Cancer Stem Cells in Retinoblastoma In Vitro. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 62(14). doi:10.1167/iovs.62.14.13
Patient-derived zebrafish xenograft models reveal ferroptosis as a fatal and druggable weakness in metastatic uveal melanoma
Understanding the Metabolomics of Uveal Melanoma
Matareed, M., Figueiredo, C., Muhamadali, H., Goodacre, R., Muelas, M. W., Kalirai, H., & Coupland, S. E. (2021). Understanding the Metabolomics of Uveal Melanoma. In JOURNAL OF PATHOLOGY Vol. 255 (pp. S54). Retrieved from https://www.webofscience.com/
Proteomics of Primary Uveal Melanoma: Insights into Metastasis and Protein Biomarkers
Jang, G. -F., Crabb, J. S., Hu, B., Willard, B., Kalirai, H., Singh, A. D., . . . Crabb, J. W. (2021). Proteomics of Primary Uveal Melanoma: Insights into Metastasis and Protein Biomarkers. CANCERS, 13(14). doi:10.3390/cancers13143520
Conditional Survival in Uveal Melanoma
Zabor, E. C., Radivoyevitch, T., Singh, A. D., Kilic, E., de Klein, J. E. M. M., Kalirai, H., & Coupland, S. E. (2021). Conditional Survival in Uveal Melanoma. OPHTHALMOLOGY RETINA, 5(6), 536-542. doi:10.1016/j.oret.2020.09.015
Small High-Risk Uveal Melanomas Have a Lower Mortality Rate
Hussain, R. N., Coupland, S. E., Kalirai, H., Taktak, A. F. G., Eleuteri, A., Damato, B. E., . . . Heimann, H. (2021). Small High-Risk Uveal Melanomas Have a Lower Mortality Rate. CANCERS, 13(9). doi:10.3390/cancers13092267
Cost-utility analysis of a decade of liver screening for metastases using the Liverpool Uveal Melanoma Prognosticator Online (LUMPO)
Eleuteri, A., Rola, A. C., Kalirai, H., Hussain, R., Sacco, J., Damato, B. E., . . . Taktak, A. F. G. (2021). Cost-utility analysis of a decade of liver screening for metastases using the Liverpool Uveal Melanoma Prognosticator Online (LUMPO). COMPUTERS IN BIOLOGY AND MEDICINE, 130. doi:10.1016/j.compbiomed.2021.104221
Optimisation of Decellularisation Protocols to Study the Extracellular Matrix in Uveal Melanoma
Kalirai, H., Aughton, K., & Coupland, S. E. (2021). Optimisation of Decellularisation Protocols to Study the Extracellular Matrix in Uveal Melanoma. In JOURNAL OF PATHOLOGY Vol. 255 (pp. S54). Retrieved from https://www.webofscience.com/
Targeting Oncogenic Gaq Signalling with Focal Adhesion Kinase Inhibitors in Three-Dimensional Models of Uveal Melanoma
Aughton, K., Sacco, J., Devlin, M., Lambert, J., Coupland, S. E., & Kalirai, H. (2021). Targeting Oncogenic Gaq Signalling with Focal Adhesion Kinase Inhibitors in Three-Dimensional Models of Uveal Melanoma. In JOURNAL OF PATHOLOGY Vol. 255 (pp. S54). Retrieved from https://www.webofscience.com/
2020
High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells
Slater, K., Heeran, A. B., Garcia-Mulero, S., Kalirai, H., Sanz-Pamplona, R., Rahman, A., . . . Kennedy, B. N. (2020). High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells. CANCERS, 12(10). doi:10.3390/cancers12102950
Effects of plaque brachytherapy and proton beam radiotherapy on prognostic testing: a comparison of uveal melanoma genotyped by microsatellite analysis
Thornton, S., Coupland, S. E., Heimann, H., Hussain, R., Groenewald, C., Kacperek, A., . . . Kalirai, H. (2020). Effects of plaque brachytherapy and proton beam radiotherapy on prognostic testing: a comparison of uveal melanoma genotyped by microsatellite analysis. BRITISH JOURNAL OF OPHTHALMOLOGY, 104(10), 1462-1466. doi:10.1136/bjophthalmol-2019-315363
Transcriptome Profiling Reveals New Insights into the Immune Microenvironment and Upregulation of Novel Biomarkers in Metastatic Uveal Melanoma
Krishna, Y., Acha-Sagredo, A., Sabat-Pospiech, D., Kipling, N., Clarke, K., Figueiredo, C. R., . . . Coupland, S. E. (2020). Transcriptome Profiling Reveals New Insights into the Immune Microenvironment and Upregulation of Novel Biomarkers in Metastatic Uveal Melanoma. CANCERS, 12(10). doi:10.3390/cancers12102832
Piloting a Deep Learning Model for Predicting Nuclear BAP1 Immunohistochemical Expression of Uveal Melanoma from Hematoxylin-and-Eosin Sections
Zhang, H., Kalirai, H., Acha-Sagredo, A., Yang, X., Zheng, Y., & Coupland, S. E. (2020). Piloting a Deep Learning Model for Predicting Nuclear BAP1 Immunohistochemical Expression of Uveal Melanoma from Hematoxylin-and-Eosin Sections. Translational Vision Science & Technology, 9(2). doi:10.1167/tvst.9.2.50
High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells
MicroRNAs and Uveal Melanoma: Understanding the Diverse Role of These Small Molecular Regulators.
Aughton, K., Kalirai, H., & Coupland, S. E. (2020). MicroRNAs and Uveal Melanoma: Understanding the Diverse Role of These Small Molecular Regulators.. International Journal of Molecular Sciences, 21(16). doi:10.3390/ijms21165648
Melanoblasts Populate the Mouse Choroid Earlier in Development Than Previously Described
Coupland, S. (2020). Melanoblasts Populate the Mouse Choroid Earlier in Development Than Previously Described. Investigative Ophthalmology and Visual Science, 61(10). doi:10.1167/iovs.61.10.33
Unpacking the genetic etiology of uveal melanoma
Thornton, S., Kalirai, H., Aughton, K., & Coupland, S. E. (2020). Unpacking the genetic etiology of uveal melanoma. Expert Review of Ophthalmology. doi:10.1080/17469899.2020.1785872
Characterization of Uveal Melanoma Cell Lines and Primary Tumor Samples in 3D Culture
Aughton, K., Shahidipour, H., Djirackor, L., Coupland, S. E., & Kalirai, H. (2020). Characterization of Uveal Melanoma Cell Lines and Primary Tumor Samples in 3D Culture. Translational Vision Science and Technology, 9(7). doi:10.1167/tvst.9.7.39
Image Analysis of 3D Conjunctival Melanoma Cell Cultures Following Electrochemotherapy
Fiorentzis, M., Katopodis, P., Kalirai, H., Seitz, B., Viestenz, A., & Coupland, S. E. (2020). Image Analysis of 3D Conjunctival Melanoma Cell Cultures Following Electrochemotherapy. Biomedicines, 8(6), 158. doi:10.3390/biomedicines8060158
Inhibition of ATM Increases the Radiosensitivity of Uveal Melanoma Cells to Photons and Protons
Hussain, R. N., Coupland, S. E., Khzouz, J., Kalirai, H., & Parsons, J. L. (n.d.). Inhibition of ATM Increases the Radiosensitivity of Uveal Melanoma Cells to Photons and Protons. Cancers, 12(6), 1388. doi:10.3390/cancers12061388
Targeted Next-Generation Sequencing of 117 Routine Clinical Samples Provides Further Insights into the Molecular Landscape of Uveal Melanoma
Thornton, S., Coupland, S. E., Olohan, L., Sibbring, J. S., Kenny, J. G., Hertz-Fowler, C., . . . Kalirai, H. (2020). Targeted Next-Generation Sequencing of 117 Routine Clinical Samples Provides Further Insights into the Molecular Landscape of Uveal Melanoma. CANCERS, 12(4). doi:10.3390/cancers12041039
Parsimonious Models for Predicting Mortality from Choroidal Melanoma.
Damato, B., Eleuteri, A., Hussain, R., Kalirai, H., Thornton, S., Taktak, A., . . . Coupland, S. E. (2020). Parsimonious Models for Predicting Mortality from Choroidal Melanoma.. Investigative ophthalmology & visual science, 61(4), 35. doi:10.1167/iovs.61.4.35
Genome-wide study on uveal melanoma patients finds association to DNA repair gene TDP1.
Thomsen, H., Chattopadhyay, S., Hoffmann, P., Nöthen, M. M., Kalirai, H., Coupland, S. E., . . . Försti, A. (2020). Genome-wide study on uveal melanoma patients finds association to DNA repair gene TDP1.. Melanoma research, 30(2), 166-172. doi:10.1097/cmr.0000000000000641
Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development.
Figueiredo, C. R., Kalirai, H., Sacco, J. J., Azevedo, R. A., Duckworth, A., Slupsky, J. R., . . . Coupland, S. E. (2020). Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development.. The Journal of Pathology, 250(4), 420-439. doi:10.1002/path.5384
Multicenter External Validation of the Liverpool Uveal Melanoma Prognosticator Online: An OOG Collaborative Study
Rola, A. C., Taktak, A., Eleuteri, A., Kalirai, H., Heimann, H., Hussain, R., . . . Coupland, S. E. (2020). Multicenter External Validation of the Liverpool Uveal Melanoma Prognosticator Online: An OOG Collaborative Study. CANCERS, 12(2). doi:10.3390/cancers12020477
Importance of Partial Losses of Chromosome 3 in Uveal Melanoma in the BAP1 Gene Region
Coupland, S. E., Thornton, S., & Kalirai, H. (2020). Importance of Partial Losses of Chromosome 3 in Uveal Melanoma in the BAP1 Gene Region. JAMA OPHTHALMOLOGY, 138(2), 188-189. doi:10.1001/jamaophthalmol.2019.5491
Cysteinyl leukotriene receptor 1 (CysLT1) is associated with clinical parameters of uveal melanoma and CysLT receptor antagonists inhibit cancer hallmarks <i>in vitro</i> and <i>in vivo</i>
Slater, K., Heeran, A., Helmi, M., Kalirai, H., Coupland, S. E., Villanueva, A., . . . Kennedy, B. N. (2020). Cysteinyl leukotriene receptor 1 (CysLT1) is associated with clinical parameters of uveal melanoma and CysLT receptor antagonists inhibit cancer hallmarks <i>in vitro</i> and <i>in vivo</i>. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 61. Retrieved from https://www.webofscience.com/
Melanocytes populate the mouse choroid earlier in development than previously described
Shields, G. T., Seyed-Razavi, Y., Kalirai, H., Insall, R. H., Machesky, L. M., Coupland, S. E., & McMenamin, P. G. (2020). Melanocytes populate the mouse choroid earlier in development than previously described. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 61. Retrieved from https://www.webofscience.com/
2019
So Close, yet so Far: Discrepancies between Uveal and Other Melanomas. A Position Paper from UM Cure 2020
Rodrigues, M., de Koning, L., Coupland, S. E., Jochemsen, A. G., Marais, R., Stern, M. -H., . . . Plomp, D. (2019). So Close, yet so Far: Discrepancies between Uveal and Other Melanomas. A Position Paper from UM Cure 2020. CANCERS, 11(7). doi:10.3390/cancers11071032
Phenotypic profile and role of cancer stem cells in uveal melanoma
Djirackor, L. K. (2019, June 19). Phenotypic profile and role of cancer stem cells in uveal melanoma.
CD166(high) Uveal Melanoma Cells Represent a Subpopulation With Enhanced Migratory Capacity
Djirackor, L., Kalirai, H., Coupland, S. E., & Petrovski, G. (2019). CD166(high) Uveal Melanoma Cells Represent a Subpopulation With Enhanced Migratory Capacity. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 60(7), 2696-2704. doi:10.1167/iovs.18-26431
Conjunctival melanoma and electrochemotherapy: preliminary results using 2D and 3D cell culture models <i>in vitro</i>
Fiorentzis, M., Katopodis, P., Kalirai, H., Seitz, B., Viestenz, A., & Coupland, S. E. (2019). Conjunctival melanoma and electrochemotherapy: preliminary results using 2D and 3D cell culture models <i>in vitro</i>. ACTA OPHTHALMOLOGICA, 97(4), E632-E640. doi:10.1111/aos.13993
Conjunctival melanoma copy number alterations and correlation with mutation status, tumor features and clinical outcome.
Kenawy, N., Kalirai, H., Sacco, J. J., Lake, S. L., Heegaard, S., Larsen, A. -C., . . . Coupland, S. E. (2019). Conjunctival melanoma copy number alterations and correlation with mutation status, tumor features and clinical outcome.. Pigment cell & melanoma research, 32(4), 564-575. doi:10.1111/pcmr.12767
A 3D spheroid model of Uveal Melanoma (UM)
Djirackor, L., Shahidipour, H., Coupland, S. E., & Kalirai, H. (2019). A 3D spheroid model of Uveal Melanoma (UM). In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 60. Retrieved from https://www.webofscience.com/
Characterising the Response of a Metastatic Uveal Melanoma Cell Line to Hypoxia Using a Chick Embryo Model
Scullion, N., Alexander, J., Kalirai, H., Aughton, K., & Coupland, S. E. (2019). Characterising the Response of a Metastatic Uveal Melanoma Cell Line to Hypoxia Using a Chick Embryo Model. In JOURNAL OF PATHOLOGY Vol. 249 (pp. S44). Retrieved from https://www.webofscience.com/
Developing Next Generation Sequencing (NGS) Panels for Uveal Melanoma to Detect Copy Number and Single Nucleotide Variants
Thornton, S., Kalirai, H., Sibbring, J., Olohan, L., Kenny, J., Liu, X., . . . Coupland, S. E. (2019). Developing Next Generation Sequencing (NGS) Panels for Uveal Melanoma to Detect Copy Number and Single Nucleotide Variants. In JOURNAL OF PATHOLOGY Vol. 248 (pp. S13). Retrieved from https://www.webofscience.com/
Genetics of Uveal Melanoma
Kalirai, H., Tsygankov, A. I., Thornton, S., Saakyan, S. V., & Coupland, S. E. (2020). Genetics of Uveal Melanoma. In INTRAOCULAR TUMORS (pp. 81-91). doi:10.1007/978-981-15-0395-5_7
Histomorphological Changes and DNA Repair Protein Expression in Uveal Melanoma (UM) Following Proton Beam Therapy (PBR)
Khzouz, J., Hussain, R., Heimann, H., Kalirai, H., Aughton, K., Scullion, N., & Coupland, S. (2019). Histomorphological Changes and DNA Repair Protein Expression in Uveal Melanoma (UM) Following Proton Beam Therapy (PBR). In JOURNAL OF PATHOLOGY Vol. 248 (pp. S21). Retrieved from https://www.webofscience.com/
Modelling Rhabdomyosarcoma Using the Chick Embryo Model
Rawson, E., Petts, G., Alexander, J., Kalirai, H., & Coupland, S. E. (2019). Modelling Rhabdomyosarcoma Using the Chick Embryo Model. In JOURNAL OF PATHOLOGY Vol. 249 (pp. S44). Retrieved from https://www.webofscience.com/
Phenotypic plasticity in uveal melanoma spheroids
Kalirai, H., Djirackor, L., & Coupland, S. E. (2019). Phenotypic plasticity in uveal melanoma spheroids. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 60. Retrieved from https://www.webofscience.com/
Proteomics of Metastatic and Non-Metastatic Uveal Melanoma
Crabb, J. W., Crabb, J. S., Jang, G. -F., Willard, B., Hu, B., Kalirai, H., . . . Coupland, S. E. (2019). Proteomics of Metastatic and Non-Metastatic Uveal Melanoma. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 60. Retrieved from https://www.webofscience.com/
Role of Hypoxia in RetinoblastomaY79 cell line
Vemuganti, G. K., Narayana, R. V. L., Alexander, J., Kalirai, H., Kondapi, A., Kaliki, S., . . . Coupland, S. E. (2019). Role of Hypoxia in RetinoblastomaY79 cell line. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 60. Retrieved from https://www.webofscience.com/
The Role of CD166/ALCAM in Uveal Melanoma Metastasis
Djirackor, L., Kalirai, H., & Coupland, S. E. (2019). The Role of CD166/ALCAM in Uveal Melanoma Metastasis. In JOURNAL OF PATHOLOGY Vol. 248 (pp. S21). Retrieved from https://www.webofscience.com/
Transcriptomic analysis reveals genes and miRNAs dysregulated in high risk primary uveal melanoma
Aughton, K., Lake, S. L., Takeshita, L., Falciani, F., Kalirai, H., & Coupland, S. E. (2019). Transcriptomic analysis reveals genes and miRNAs dysregulated in high risk primary uveal melanoma. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 60. Retrieved from https://www.webofscience.com/
Use of the Chick Embryo Chorioallantoic Membrane (CAM) Model in Uveal Melanoma
Oliver, C., Alexander, J., Kalirai, H., & Coupland, S. E. (2019). Use of the Chick Embryo Chorioallantoic Membrane (CAM) Model in Uveal Melanoma. In JOURNAL OF PATHOLOGY Vol. 248 (pp. S21). Retrieved from https://www.webofscience.com/
Using Mass-Cytometry approach for the characterisation of the microenvironment of primary uveal melanoma
De Figueiredo, C. R., Kalirai, H., Sacco, J., Coulson, J., & Coupland, S. E. (2019). Using Mass-Cytometry approach for the characterisation of the microenvironment of primary uveal melanoma. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 60. Retrieved from https://www.webofscience.com/
Using Transcriptomics to Define Metastatic Risk in Uveal Melanoma
Aughton, K., Lake, S. L., Kalirai, H., & Coupland, S. E. (2019). Using Transcriptomics to Define Metastatic Risk in Uveal Melanoma. In JOURNAL OF PATHOLOGY Vol. 248 (pp. S13). Retrieved from https://www.webofscience.com/
Validation of Choroid from Uveal Melanoma Eyes as Control Tissue for Proteomic Studies
Jang, G. -F., Crabb, J. S., Hu, B., Willard, B., Kalirai, H., Singh, A. D., . . . Crabb, J. W. (2019). Validation of Choroid from Uveal Melanoma Eyes as Control Tissue for Proteomic Studies. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 60. Retrieved from https://www.webofscience.com/
2018
Detection of mutations in <i>SF3B1</i>, <i>EIF1AX</i> and <i>GNAQ</i> in primary orbital melanoma by candidate gene analysis
Rose, A. M., Luo, R., Radia, U. K., Kalirai, H., Thornton, S., Luthert, P. J., . . . Rose, G. E. (2018). Detection of mutations in <i>SF3B1</i>, <i>EIF1AX</i> and <i>GNAQ</i> in primary orbital melanoma by candidate gene analysis. BMC CANCER, 18. doi:10.1186/s12885-018-5190-z
Prognostication of metastatic death in uveal melanoma patients: A Markov multi-state model
Eleuteri, A., Taktak, A. F. G., Coupland, S. E., Heimann, H., Kalirai, H., & Damato, B. (2018). Prognostication of metastatic death in uveal melanoma patients: A Markov multi-state model. COMPUTERS IN BIOLOGY AND MEDICINE, 102, 151-156. doi:10.1016/j.compbiomed.2018.09.024
Nestin expression in primary and metastatic uveal melanoma - possible biomarker for high-risk uveal melanoma
Djirackor, L., Shakir, D., Kalirai, H., Petrovski, G., & Coupland, S. E. (2018). Nestin expression in primary and metastatic uveal melanoma - possible biomarker for high-risk uveal melanoma. ACTA OPHTHALMOLOGICA, 96(5), 503-509. doi:10.1111/aos.13645
Altered Nuclear Expression of the Deubiquitylase BAP1 Cannot be Used as a Prognostic Marker for Canine Melanoma
Jama, N., Farquhar, N., Butt, Z., Coupland, S. E., Sacco, J. J., Scase, T., . . . Killick, D. R. (2018). Altered Nuclear Expression of the Deubiquitylase BAP1 Cannot be Used as a Prognostic Marker for Canine Melanoma. Journal of Comparative Pathology, 162, 50-58. doi:10.1016/j.jcpa.2018.06.007
Liver fibrosis and metastatic uveal melanoma (mUM)
Coupland, S. E., Prendergast, S., Ahmed, I., Sakai, T., & Kalirai, H. (2018). Liver fibrosis and metastatic uveal melanoma (mUM). In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 59. Retrieved from https://www.webofscience.com/
Recent breakthroughs in metastatic uveal melanoma: a cause for optimism?
Sacco, J. J., Kalirai, H., Kenyani, J., Figueiredo, C. R., Coulson, J. M., & Coupland, S. E. (2018). Recent breakthroughs in metastatic uveal melanoma: a cause for optimism?. FUTURE ONCOLOGY, 14(14), 1335-1338. doi:10.2217/fon-2018-0116
Combined mutation and copy-number variation detection by targeted next-generation sequencing in uveal melanoma
Smit, K. N., van Poppelen, N. M., Vaarwater, J., Verdijk, R., van Marion, R., Kalirai, H., . . . Kilic, E. (2018). Combined mutation and copy-number variation detection by targeted next-generation sequencing in uveal melanoma. MODERN PATHOLOGY, 31(5), 763-771. doi:10.1038/modpathol.2017.187
Multiple primary malignancies and prolonged survival in a patient with widespread metastatic cutaneous melanoma
Rose, A. M., Radia, U. K., Luo, R., Kalirai, H., Jayasena, C. N., Luthert, P., . . . Rose, G. E. (2018). Multiple primary malignancies and prolonged survival in a patient with widespread metastatic cutaneous melanoma. MELANOMA RESEARCH, 28(2), 163-166. doi:10.1097/CMR.0000000000000426
Electrochemotherapy with bleomycin and cisplatin enhances cytotoxicity in primary and metastatic uveal melanoma cell lines in vitro
Fiorentzis, M., Kalirai, H., Katopodis, P., Seitz, B., Viestenz, A., & Coupland, S. E. (2018). Electrochemotherapy with bleomycin and cisplatin enhances cytotoxicity in primary and metastatic uveal melanoma cell lines in vitro. NEOPLASMA, 65(2), 210-215. doi:10.4149/neo_2018_170329N227
Kinome‐wide transcriptional profiling of uveal melanoma reveals new vulnerabilities to targeted therapeutics
Bailey, F. P., Clarke, K., Kalirai, H., Kenyani, J., Shahidipour, H., Falciani, F., . . . Eyers, P. A. (2018). Kinome‐wide transcriptional profiling of uveal melanoma reveals new vulnerabilities to targeted therapeutics. Pigment Cell and Melanoma Research, 31(2), 253-266. doi:10.1111/pcmr.12650
Developing Next Generation Sequencing (NGS) Panels for Uveal Melanoma to Detect Copy Number and Single Nucleotide Variants; comparing PCR and Hybrid Capture Target Enrichment
Thornton, S., Kalirai, H., Sibbring, J., Olohan, L., Kenny, J., Lui, X., . . . Coupland, S. E. (2018). Developing Next Generation Sequencing (NGS) Panels for Uveal Melanoma to Detect Copy Number and Single Nucleotide Variants; comparing PCR and Hybrid Capture Target Enrichment. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 59. Retrieved from https://www.webofscience.com/
Patterns of BAP1 protein expression provide insights into prognostic significance and the biology of uveal melanoma
Farquhar, N., Thornton, S., Coupland, S. E., Coulson, J., Sacco, J. J., Krishna, Y., . . . Kalirai, H. (2018). Patterns of BAP1 protein expression provide insights into prognostic significance and the biology of uveal melanoma. The Journal of Pathology: Clinical Research, 4(1), 26-38. doi:10.1002/cjp2.86
The interaction of uveal melanoma (UM) with Hepatic Stellate Cells (HSC).
Ahmed, I., Prendergast, S., Kalirai, H., & Coupland, S. E. (2018). The interaction of uveal melanoma (UM) with Hepatic Stellate Cells (HSC).. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 59. Retrieved from https://www.webofscience.com/
2017
Ocular melanomas. An update
Kalirai, H., Mueller, P. L., Jaehne, D., & Coupland, S. E. (2017). Ocular melanomas. An update. PATHOLOGE, 38(6), 491-499. doi:10.1007/s00292-017-0389-3
Nestin expression in primary and metastatic uveal melanoma
Djirackor, L., Shakir, D., Kalirai, H., Petrovksi, G., & Coupland, S. (2017). Nestin expression in primary and metastatic uveal melanoma. In ACTA OPHTHALMOLOGICA Vol. 95. doi:10.1111/j.1755-3768.2017.03644
Inflammatory cell infiltrates in advanced metastatic uveal melanoma
Krishna, Y., McCarthy, C., Kalirai, H., & Coupland, S. E. (2017). Inflammatory cell infiltrates in advanced metastatic uveal melanoma. HUMAN PATHOLOGY, 66, 159-166. doi:10.1016/j.humpath.2017.06.005
Prognostic biopsy of choroidal melanoma: an optimised surgical and laboratory approach
Angi, M., Kalirai, H., Taktak, A., Hussain, R., Groenewald, C., Damato, B. E., . . . Coupland, S. E. (2017). Prognostic biopsy of choroidal melanoma: an optimised surgical and laboratory approach. BRITISH JOURNAL OF OPHTHALMOLOGY, 101(8), 1143-1146. doi:10.1136/bjophthalmol-2017-310361
RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma
Chen, X., Wu, Q., Depeille, P., Chen, P., Thornton, S., Kalirai, H., . . . Bastian, B. C. (2017). RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma. Cancer Cell, 31(5), 685-696.e6. doi:10.1016/j.ccell.2017.04.002
Adipophilin expression in primary and metastatic uveal melanoma: a pilot study
Fiorentzis, M., Kalirai, H., Katopodis, P., & Coupland, S. E. (2017). Adipophilin expression in primary and metastatic uveal melanoma: a pilot study. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 255(5), 1049-1051. doi:10.1007/s00417-017-3630-0
Optimising Technical Protocols to Detect AID Expression in Archived FFPE Samples of Patients with Follicular Lymphoma
Alishlash, O., Lin, K., Coupland, S., Oates, M., Kalirai, H., & Pettitt, A. (2017). Optimising Technical Protocols to Detect AID Expression in Archived FFPE Samples of Patients with Follicular Lymphoma. In JOURNAL OF PATHOLOGY Vol. 241 (pp. S11). Retrieved from https://www.webofscience.com/
Adipophilin expression in primary and metastatic uveal melanoma: a pilot study
Coupland, S. E., Kalirai, H., Katopodis, P., Heimann, H., & Fiorentzis, M. (2017). Adipophilin expression in primary and metastatic uveal melanoma: a pilot study. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 58. Retrieved from https://www.webofscience.com/
The response of uveal melanoma (UM) cells to Bromodomain and Extra Terminal (BET) inhibitors
Bailey, F. P., Kalirai, H., Shahidipour, H., Clarke, K., Coupland, S. E., & Eyers, P. A. (2017). The response of uveal melanoma (UM) cells to Bromodomain and Extra Terminal (BET) inhibitors. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 58. Retrieved from https://www.webofscience.com/
2016
Electroporation enhances chemosensitivity of uveal melanoma cells
Fiorentzis, M., Katopodis, P., Kalirai, H., Seitz, B., Viestenz, A., & Coupland, S. E. (2016). Electroporation enhances chemosensitivity of uveal melanoma cells. In ACTA OPHTHALMOLOGICA Vol. 94. doi:10.1111/j.1755-3768.2016.0477
Inflammatory Cell Infiltrates in Advanced Metastatic Uveal Melanoma
Krishna, Y., McCarthy, C., Kalirai, H., & Coupland, S. E. (2017). Inflammatory Cell Infiltrates in Advanced Metastatic Uveal Melanoma. In JOURNAL OF PATHOLOGY Vol. 243 (pp. S15). Retrieved from https://www.webofscience.com/
Prognostic Biopsy of Choroidal Melanoma after Proton Beam Radiation Therapy
Hussain, R. N., Kalirai, H., Groenewald, C., Kacperek, A., Errington, R. D., Coupland, S. E., . . . Damato, B. (2016). Prognostic Biopsy of Choroidal Melanoma after Proton Beam Radiation Therapy. OPHTHALMOLOGY, 123(10), 2264-2265. doi:10.1016/j.ophtha.2016.05.028
In-depth proteomic profiling of the uveal melanoma secretome
Angi, M., Kalirai, H., Prendergast, S., Simpson, D., Hammond, D. E., Madigan, M. C., . . . Coupland, S. E. (2016). In-depth proteomic profiling of the uveal melanoma secretome. Oncotarget, 7(31), 49623-49635. doi:10.18632/oncotarget.10418
Genetic findings in treatment-naive and proton-beam-radiated iris melanomas
Krishna, Y., Kalirai, H., Thornton, S., Damato, B. E., Heimann, H., & Coupland, S. E. (2016). Genetic findings in treatment-naive and proton-beam-radiated iris melanomas. BRITISH JOURNAL OF OPHTHALMOLOGY, 100(7), 1012-1016. doi:10.1136/bjophthalmol-2015-308301
Non-ocular primary malignancies in patients with uveal melanoma: the Liverpool experience
Heussen, F. M., Coupland, S. E., Kalirai, H., Damato, B. E., & Heimann, H. (2016). Non-ocular primary malignancies in patients with uveal melanoma: the Liverpool experience. BRITISH JOURNAL OF OPHTHALMOLOGY, 100(3), 356-359. doi:10.1136/bjophthalmol-2015-306914
Animal Models of Ocular Tumors
Jager, M. J., Cao, J., Yang, H., Decaudin, D., Kalirai, H., van der Ent, W., . . . Coupland, S. E. (2016). Animal Models of Ocular Tumors. In ANIMAL MODELS OF OPHTHALMIC DISEASES (pp. 127-140). doi:10.1007/978-3-319-19434-9_9
Bilateral Diffuse Uveal Melanocytic Proliferation: Molecular Genetic Analysis of a Case and Review of the Literature
Mittal, R., Cherepanoff, S., Thornton, S., Kalirai, H., Damato, B., & Coupland, S. E. (2016). Bilateral Diffuse Uveal Melanocytic Proliferation: Molecular Genetic Analysis of a Case and Review of the Literature. OCULAR ONCOLOGY AND PATHOLOGY, 2(2), 94-99. doi:10.1159/000440766
Does Proton Beam Radiotherapy Diminish the Reliability of Prognostic Genetic Analysis of Choroidal Melanoma?
Damato, B. E., Hussein, R. N., Taktak, A. F. G., Kalirai, H., Thornton, S., Heimann, H., & Coupland, S. E. (2016). Does Proton Beam Radiotherapy Diminish the Reliability of Prognostic Genetic Analysis of Choroidal Melanoma?. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 57. Retrieved from https://www.webofscience.com/
Insights into genetic alterations of liver metastases from uveal melanoma
McCarthy, C., Kalirai, H., Lake, S. L., Dodson, A., Damato, B. E., & Coupland, S. E. (2016). Insights into genetic alterations of liver metastases from uveal melanoma. PIGMENT CELL & MELANOMA RESEARCH, 29(1), 60-67. doi:10.1111/pcmr.12433
Proteomic analysis of uveal melanoma (UM) secretome reveals novel biological insights and potential biomarkers
Coupland, S. E., Prendergast, S., Angi, M., Simpson, D., Beynon, R., & Kalirai, H. (2016). Proteomic analysis of uveal melanoma (UM) secretome reveals novel biological insights and potential biomarkers. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 57. Retrieved from https://www.webofscience.com/
Use of the Chick Embryo Model in Uveal Melanoma (vol 1, pg 133, 2015)
Kalirai, H., Shahidipour, H., Moss, D., Coupland, S. E., & Luyten, G. P. M. (2016). Use of the Chick Embryo Model in Uveal Melanoma (vol 1, pg 133, 2015). OCULAR ONCOLOGY AND PATHOLOGY, 2(1), 59. doi:10.1159/000440675
2015
Concordant chromosome 3 results in paired choroidal melanoma biopsies and subsequent tumour resection specimens
Coupland, S. E., Kalirai, H., Ho, V., Thornton, S., Damato, B. E., & Heimann, H. (2015). Concordant chromosome 3 results in paired choroidal melanoma biopsies and subsequent tumour resection specimens. BRITISH JOURNAL OF OPHTHALMOLOGY, 99(10), 1444-1450. doi:10.1136/bjophthalmol-2015-307057
Proteomic analysis of the uveal melanoma (UM) secretome reveals novel insights and potential biomarkers
Angi, M., Kalirai, H., & Coupland, S. (2015). Proteomic analysis of the uveal melanoma (UM) secretome reveals novel insights and potential biomarkers. In ACTA OPHTHALMOLOGICA Vol. 93. doi:10.1111/j.1755-3768.2015.0621
Two Distinct Uveal Melanomas in the Same Eye
Nissen, E. J., Kalirai, H., Damato, B., Heimann, H., & Coupland, S. E. (2015). Two Distinct Uveal Melanomas in the Same Eye. JAMA OPHTHALMOLOGY, 133(9), 1094-1096. doi:10.1001/jamaophthalmol.2015.1962
Culturing Uveal Melanoma Cells
Angi, M., Versluis, M., & Kalirai, H. (2015). Culturing Uveal Melanoma Cells. OCULAR ONCOLOGY AND PATHOLOGY, 1(3), 126-132. doi:10.1159/000370150
Use of the Chick Embryo Model in Uveal Melanoma
Kalirai, H., Shahidipour, H., Coupland, S. E., & Luyten, G. P. M. (2015). Use of the Chick Embryo Model in Uveal Melanoma. OCULAR ONCOLOGY AND PATHOLOGY, 1(3), 133-140. doi:10.1159/000370151
Cluster analysis of multiplex ligation-dependent probe amplification data in choroidal melanoma
Caines, R., Eleuteri, A., Kalirai, H., Fisher, A. C., Heimann, H., Damato, B. E., . . . Taktak, A. F. G. (2015). Cluster analysis of multiplex ligation-dependent probe amplification data in choroidal melanoma. MOLECULAR VISION, 21, 1-11. Retrieved from https://www.webofscience.com/
An update on ocular melanoma
Kalirai, H., & Coupland, S. E. (2015). An update on ocular melanoma. Diagnostic Histopathology, 21(1), 19-25. doi:10.1016/j.mpdhp.2014.11.002
Insights into Genetic Alterations of Liver Metastases from Uveal Melanoma
Hanke, C., Dodson, A., Lake, S., Kalirai, H., & Coupland, S. E. (2015). Insights into Genetic Alterations of Liver Metastases from Uveal Melanoma. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 56. Retrieved from https://www.webofscience.com/
2014
SERPINE1 and SMA expression at the invasive front predict extracapsular spread and survival in oral squamous cell carcinoma
Dhanda, J., Triantafyllou, A., Liloglou, T., Kalirai, H., Lloyd, B., Hanlon, R., . . . Risk, J. (2014). SERPINE1 and SMA expression at the invasive front predict extracapsular spread and survival in oral squamous cell carcinoma. British Journal of Cancer, 111(11), 2114-2121. doi:10.1038/bjc.2014.500
Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing
Kalirai, H., Dodson, A., Faqir, S., Damato, B. E., & Coupland, S. E. (2014). Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing. BRITISH JOURNAL OF CANCER, 111(7), 1373-1380. doi:10.1038/bjc.2014.417
Multiple malignancies in uveal melanoma patients - the LOOC experience
Heussen, F. M., Damato, B., Kalirai, H., Coupland, S. E., & Heimann, H. (2014). Multiple malignancies in uveal melanoma patients - the LOOC experience. ACTA OPHTHALMOLOGICA, 92. doi:10.1111/j.1755-3768.2014.4243.x
New insights into uveal melanoma
Kalirai, H. (2014). New insights into uveal melanoma. In ACTA OPHTHALMOLOGICA Vol. 92. doi:10.1111/j.1755-3768.2014.3754.x
Age, Survival Predictors, and Metastatic Death in Patients With Choroidal Melanoma Tentative Evidence of a Therapeutic Effect on Survival
Damato, B. E., Heimann, H., Kalirai, H., & Coupland, S. E. (2014). Age, Survival Predictors, and Metastatic Death in Patients With Choroidal Melanoma Tentative Evidence of a Therapeutic Effect on Survival. JAMA OPHTHALMOLOGY, 132(5), 605-613. doi:10.1001/jamaophthalmol.2014.77
Chick embryo model systems to study uveal melanoma metastasis
Shahidipour, H., Coupland, S. E., Moss, D., Damato, B. E., & Kalirai, H. (2014). Chick embryo model systems to study uveal melanoma metastasis. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 55. Retrieved from https://www.webofscience.com/
Comparison of uveal melanoma prognostication test results of the 'paired' intraocular biopsy with the subsequently enucleated eye
Coupland, S. E., Kalirai, H., Ho, V., Damato, B. E., & Heimann, H. (2014). Comparison of uveal melanoma prognostication test results of the 'paired' intraocular biopsy with the subsequently enucleated eye. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 55. Retrieved from https://www.webofscience.com/
Does choroidal melanoma regression correlate with chromosome 3 loss after ruthenium brachytherapy?
Chiam, P. J. T., Coupland, S. E., Kalirai, H., Groenewald, C., Heimann, H., & Damato, B. E. (2014). Does choroidal melanoma regression correlate with chromosome 3 loss after ruthenium brachytherapy?. BRITISH JOURNAL OF OPHTHALMOLOGY, 98(7), 967-971. doi:10.1136/bjophthalmol-2013-304472
Prognostication in Choroidal Melanoma
Coupland, S. E., Taktak, A., Eleuteri, A., Kalirai, H., & Damato, B. (2014). Prognostication in Choroidal Melanoma. In Clinical Ophthalmic Oncology (pp. 249-261). Springer Berlin Heidelberg. doi:10.1007/978-3-642-54255-8_20
2013
Genomic Amplification Is Not a Frequent Event in Uveal Melanomas Reply
Lake, S. L., Kalirai, H., Dodson, A. R., Coupland, S. E., Lloyd, B. H., Damato, B. E., & Taktak, A. F. G. (2013). Genomic Amplification Is Not a Frequent Event in Uveal Melanomas Reply. AMERICAN JOURNAL OF PATHOLOGY, 183(2), 638-640. Retrieved from https://www.webofscience.com/
Single Nucleotide Polymorphism Array Analysis of Uveal Melanomas Reveals That Amplification of <i>CNKSR3</i> Is Correlated With Improved Patient Survival
Lake, S. L., Damato, B. E., Kalirai, H., Dodson, A. R., Taktak, A. F. G., Lloyd, B. H., & Coupland, S. E. (2013). Single Nucleotide Polymorphism Array Analysis of Uveal Melanomas Reveals That Amplification of <i>CNKSR3</i> Is Correlated With Improved Patient Survival. AMERICAN JOURNAL OF PATHOLOGY, 182(3), 678-687. doi:10.1016/j.ajpath.2012.11.036
Cancer Stem Cells in Uveal Melanoma
Kalirai, H., Damato, B. E., & Coupland, S. E. (2013). Cancer Stem Cells in Uveal Melanoma. In Stem Cell Biology and Regenerative Medicine in Ophthalmology (pp. 139-151). Springer New York. doi:10.1007/978-1-4614-5493-9_9
2012
Proteomic Analyses of the Vitreous Humour
Angi, M., Kalirai, H., Coupland, S. E., Damato, B. E., Semeraro, F., & Romano, M. R. (2012). Proteomic Analyses of the Vitreous Humour. MEDIATORS OF INFLAMMATION, 2012. doi:10.1155/2012/148039
HSP-27 protein expression in uveal melanoma: correlation with predicted survival
Jmor, F., Kalirai, H., Taktak, A., Damato, B., & Coupland, S. E. (2012). HSP-27 protein expression in uveal melanoma: correlation with predicted survival. ACTA OPHTHALMOLOGICA, 90(6), 534-539. doi:10.1111/j.1755-3768.2010.02038.x
Comparison of Formalin-Fixed and Snap-Frozen Samples Analyzed by Multiplex Ligation-Dependent Probe Amplification for Prognostic Testing in Uveal Melanoma
Lake, S. L., Kalirai, H., Dopierala, J., Damato, B. E., & Coupland, S. E. (2012). Comparison of Formalin-Fixed and Snap-Frozen Samples Analyzed by Multiplex Ligation-Dependent Probe Amplification for Prognostic Testing in Uveal Melanoma. Investigative Opthalmology & Visual Science, 53(6), 2647. doi:10.1167/iovs.12-9584
Comparison of Formalin-Fixed and Snap-Frozen Samples Analyzed by Multiplex Ligation-Dependent Probe Amplification for Prognostic Testing in Uveal Melanoma
Lake, S. L., Kalirai, H., Dopierala, J., Damato, B. E., & Coupland, S. E. (2012). Comparison of Formalin-Fixed and Snap-Frozen Samples Analyzed by Multiplex Ligation-Dependent Probe Amplification for Prognostic Testing in Uveal Melanoma. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 53(6), 2647-2652. doi:10.1167/iovs.12-9584
Combined p53 and MDM2 biomarker analysis shows a unique pattern of expression associated with poor prognosis in patients with renal cell carcinoma undergoing radical nephrectomy
Noon, A. P., Polanski, R., El-Fert, A. Y., Kalirai, H., Shawki, H., Campbell, F., . . . Boyd, M. T. (2012). Combined p53 and MDM2 biomarker analysis shows a unique pattern of expression associated with poor prognosis in patients with renal cell carcinoma undergoing radical nephrectomy. BJU INTERNATIONAL, 109(8), 1250-1257. doi:10.1111/j.1464-410X.2011.10433.x
2011
Uveal Melanoma Cell Lines Contain Stem-Like Cells That Self-Renew, Produce Differentiated Progeny, and Survive Chemotherapy
Kalirai, H., Damato, B. E., & Coupland, S. E. (2011). Uveal Melanoma Cell Lines Contain Stem-Like Cells That Self-Renew, Produce Differentiated Progeny, and Survive Chemotherapy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 52(11), 8458-8466. doi:10.1167/iovs.11-7379
Immunohistochemical assessment of mitotic count in uveal melanoma
Angi, M., Damato, B., Kalirai, H., Dodson, A., Taktak, A., & Coupland, S. E. (2011). Immunohistochemical assessment of mitotic count in uveal melanoma. ACTA OPHTHALMOLOGICA, 89(2), E155-E160. doi:10.1111/j.1755-3768.2009.01769.x
2010
Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer
Tweedle, E. M., Khattak, I., Ang, C. W., Nedjadi, T., Jenkins, R., Park, B. K., . . . Costello, E. (2010). Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer. GUT, 59(11), 1501-1510. doi:10.1136/gut.2009.196626
Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells
Ang, C. W., Nedjadi, T., Sheikh, A. A., Tweedle, E. M., Tonack, S., Honap, S., . . . Costello, E. (2010). Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells. CARCINOGENESIS, 31(9), 1541-1551. doi:10.1093/carcin/bgq137
Efficacy of sunitinib in the treatment of metastatic uveal melanoma
Jmor, F., Coupland, S., Damato, B., & Kalirai, H. (2010). Efficacy of sunitinib in the treatment of metastatic uveal melanoma. Acta Ophthalmologica, 88, s246.
HSP27 protein expression in uveal melanoma: correlation with predicted survival
Jmor, F., Kalirai, H., Taktak, A., Damato, B., & Coupland, S. (2010). HSP27 protein expression in uveal melanoma: correlation with predicted survival. Acta Ophthalmologica.
Proteomics of Uveal Melanomas Suggests HSP-27 as a Possible Surrogate Marker of Chromosome 3 Loss
Coupland, S. E., Vorum, H., Mandal, N., Kalirai, H., Honore, B., Urbak, S. F., . . . Damato, B. (2010). Proteomics of Uveal Melanomas Suggests HSP-27 as a Possible Surrogate Marker of Chromosome 3 Loss. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 51(1), 12-20. doi:10.1167/iovs.09-3913
2009
Immunohistochemical assessment of mitotic count in uveal melanoma
Angi, M., Damato, B., Kalirai, H., Dodson, A., Taktak, A., & Coupland, S. E. (2009). Immunohistochemical assessment of mitotic count in uveal melanoma. Acta Ophthalmologica, Epub ahead of print.
2008
Iodothyronine deiodinase enzyme activities in bone
Williams, A. J., Robson, H., Kester, M. H. A., van Leeuwen, J. P. T. M., Shalet, S. M., Visser, T. J., & Williams, G. R. (2008). Iodothyronine deiodinase enzyme activities in bone. Bone, 43(1), 126-134.
2006
Dexamethasone protects against cisplatin-induced activation of the mitochondrial apoptotic pathway in human osteosarcoma cells
Meyer, S., Eden, T., & Kalirai, H. (2006). Dexamethasone protects against cisplatin-induced activation of the mitochondrial apoptotic pathway in human osteosarcoma cells. CANCER BIOLOGY & THERAPY, 5(8), 915-920. doi:10.4161/cbt.5.8.2881
Review of: Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult mice
Kalirai, H., & Clarke, R. B. (2006). Review of: Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult mice. Breast Cancer Online, 9(6), 1-3. doi:10.1017/s1470903106005086
The Fifth European Growth Plate Working Group Symposium - 21st September 2005, Lyon, France - Abstracts
Kalirai, H., Phillip, M., Savendahl, L., & Wit, J. M. (2006). The Fifth European Growth Plate Working Group Symposium - 21st September 2005, Lyon, France - Abstracts. In H. Kalirai, M. Phillip, L. Savendahl, & J. M. Wit (Eds.), JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM Vol. 19 (pp. 183-190). Israel: Freund Publishing House.
Human breast epithelial stem cells and their regulation
Kalirai, H., & Clarke, R. B. (2006). Human breast epithelial stem cells and their regulation. JOURNAL OF PATHOLOGY, 208(1), 7-16. doi:10.1002/path.1881
Journal club: Review of "Proliferation of ERalpha positive mammary epithelial cells is restrained by TGF beta1 in adult mice"
Kalirai, H., & Clarke, R. (2006). Journal club: Review of "Proliferation of ERalpha positive mammary epithelial cells is restrained by TGF beta1 in adult mice". Breast Cancer Online.
The Fifth European Growth Plate Working Group Symposium. 21st September 2005, Lyon, France.
Kalirai, H., Phillip, M., Savendahl, L., & Wit, J. -M. (2006). The Fifth European Growth Plate Working Group Symposium. 21st September 2005, Lyon, France.. In Journal of pediatric endocrinology & metabolism : JPEM Vol. 19 (pp. 183-190). doi:10.1515/jpem.2006.19.2.183
2005
Thyroid and the growth plate
Robson, H. (2005). Thyroid and the growth plate. Unknown Journal, 13(2), 6-9.
2004
The Third European Growth Plate Working Group Symposium. 17th September 2003, Ljubljana, Slovenia.
Robson, H., Savendahl, L., Phillip, M., & Wit, J. M. (Eds.) (2004). The Third European Growth Plate Working Group Symposium. 17th September 2003, Ljubljana, Slovenia.. In European Society for Paediatric Endocrinology Vol. 4 (pp. 685-694). Israel: Freund Publishing House.
The effects of chemotherapy and glucocorticoids on the growth and growing skeleton during treatment for childhood cancers
Robson, H., & Shalet, S. M. (2004). The effects of chemotherapy and glucocorticoids on the growth and growing skeleton during treatment for childhood cancers. In R. Ross, & E. M. Erfurth (Eds.), Pituitary function through the ages (Vol. 8, pp. 45-58). Bristol: BioScientifica.
2003
The Second European Growth Plate Working Group Symposium 25th September 2002, Madrid, Spain.
Robson, H., Phillip, M., & Wit, J. M. (Eds.) (2003). The Second European Growth Plate Working Group Symposium 25th September 2002, Madrid, Spain.. In European Society for Paediatric Endocrinology Vol. 16 (pp. 461-466). Israel: Freund Publishing House.
The mitochondrial/caspase 9 apoptotic pathway is activated by cisplatin in osteosarcoma.
Roberts, S., Eden, O. B., & Robson, H. (2003). The mitochondrial/caspase 9 apoptotic pathway is activated by cisplatin in osteosarcoma.. Medical and Paediatric Oncology, 41, PD018.
2002
Dexamethasone inhibits and thyroid hormone promotes differentiation of mouse chondrogenic ATDC5 cells.
Siebler, T., Robson, H., Shalet, S. M., & Williams, G. R. (2002). Dexamethasone inhibits and thyroid hormone promotes differentiation of mouse chondrogenic ATDC5 cells.. Bone, 31(4), 457-464.
Effects of chemotherapy on bone metabolism and skeletal growth.
Siebler, T., Shalet, S. M., & Robson, H. (2002). Effects of chemotherapy on bone metabolism and skeletal growth.. Unknown Journal, 58(Supple), 80-85.
Interactions between GH, IGF-I, glucocorticoids, and thyroid hormones during skeletal growth.
Robson, H., Siebler, T., Shalet, S. M., & Williams, G. R. (2002). Interactions between GH, IGF-I, glucocorticoids, and thyroid hormones during skeletal growth.. Unknown Journal, 52(2), 137-147.
Molecular mechanisms of thyroid hormone effects on bone growth and function.
Harvey, C. B., O'Shea, P. J., Scott, A. J., Robson, H., Siebler, T., Shalet, S. M., . . . Williams, G. R. (2002). Molecular mechanisms of thyroid hormone effects on bone growth and function.. Unknown Journal, 75(1), 17-30.
Platinum agents in the treatment of osteosarcoma - efficacy of cisplatin versus carboplatin in human osteosarcoma cell lines.
Robson, H., Meyer, S., Shalet, S. M., Anderson, E., Roberts, S., & Eden, O. B. (2002). Platinum agents in the treatment of osteosarcoma - efficacy of cisplatin versus carboplatin in human osteosarcoma cell lines.. Medical and Paediatric Oncology, 39(6), 573-580.
Thyroid status affects number and localisation of thyroid hormone receptor expressing mast cells in bone marrow
Siebler, T., Robson, H., Bromley, M., Stevens, D. A., Shalet, S. M., & Williams, G. R. (2002). Thyroid status affects number and localisation of thyroid hormone receptor expressing mast cells in bone marrow. Bone, 30(1), 259-266.
2001
Glucocorticoids, thyroid hormone and growth hormone interactions: implications for the growth plate.
Siebler, T., Robson, H., Shalet, S. M., & Williams, G. R. (2001). Glucocorticoids, thyroid hormone and growth hormone interactions: implications for the growth plate.. Unknown Journal, 56(Supple), 7-12.
2000
Glucocorticoids modulate the cytotoxic effects of a variety of DNA damaging agents in both normal and malignant cells in vitro.
Robson, H., Eden, O. B., Anderson, E., & Shalet, S. M. (2000). Glucocorticoids modulate the cytotoxic effects of a variety of DNA damaging agents in both normal and malignant cells in vitro.. Hormone Research, 53, P1-P202.
Thyroid hormone acts directly on growth plate chondrocytes to promote hypertrophic differentiation and inhibit clonal expansion and cell proliferation.
Robson, H., Siebler, T., Stevens, D. A., Shalet, S. M., & Williams, G. R. (2000). Thyroid hormone acts directly on growth plate chondrocytes to promote hypertrophic differentiation and inhibit clonal expansion and cell proliferation.. Endocrinology, 141(10), 3887-3897.
Thyroid hormone directly promotes chondrocyte differentiation by a process that does not require prior cell proliferation.
Robson, H., Siebler, T., Stevens, D. A., Shalet, S. M., & Williams, G. R. (2000). Thyroid hormone directly promotes chondrocyte differentiation by a process that does not require prior cell proliferation.. Hormone Research, 53, OR4-OR36.
Thyroid hormones regulate hypertrophic chondrocyte differentiation and expression of parathyroid hormone-related peptide and its receptor during endochondral bone formation.
Stevens, D. A., Hasserjian, R. P., Robson, H., Siebler, T., Shalet, S. M., & Williams, G. R. (2000). Thyroid hormones regulate hypertrophic chondrocyte differentiation and expression of parathyroid hormone-related peptide and its receptor during endochondral bone formation.. Journal of Bone and Mineral Research, 15(12), 2431-2442.
Thyroid status affects number and localisation of thyroid hormone receptor expressing mast cells in bone marrow.
Siebler, T., Robson, H., Bromley, M., Stevens, D. A., Hasserjian, R. P., Shalet, S. M., & Williams, G. R. (2000). Thyroid status affects number and localisation of thyroid hormone receptor expressing mast cells in bone marrow.. Hormone Research, 53, OR7-OR54.
1999
Bone growth mechanisms and the effects of cytotoxic drugs.
Robson, H. (1999). Bone growth mechanisms and the effects of cytotoxic drugs.. Unknown Journal, 81(4), 360-364.
Comparative evaluation of cisplatin and carboplatin sensitivity in osteosarcoma cell lines.
Robson, H., Meyer, S., Shalet, S. M., Anderson, E., & Eden, O. B. (1999). Comparative evaluation of cisplatin and carboplatin sensitivity in osteosarcoma cell lines.. Medical and Paediatric Oncology, 33, O97.
Effects of glucocorticoid treatment on the expression of the non-ligand binding isoform of the glucocorticoid receptor in two human osteosarcoma cell lines, MG63 and G292.
Robson, H., Meyer, S., Shalet, S. M., Anderson, E., & Eden, O. B. (1999). Effects of glucocorticoid treatment on the expression of the non-ligand binding isoform of the glucocorticoid receptor in two human osteosarcoma cell lines, MG63 and G292.. Hormone Research, 51, P281.
Regulation of the Indian Hedgehog/PTHrP feedback loop by thyroid hormones in the rat tibial growth plate.
Robson, H., Siebler, T., Stevens, D. A., Shalet, S. M., & Williams, G. R. (1999). Regulation of the Indian Hedgehog/PTHrP feedback loop by thyroid hormones in the rat tibial growth plate.. Hormone Research, 51, O53.
T3 actions in primary cultured growth plate chondrocytes in vitro.
Robson, H., Anderson, E., Shalet, S. M., & Williams, G. R. (1999). T3 actions in primary cultured growth plate chondrocytes in vitro.. Journal of Endocrinology, 160, P6.
The anti-tumour effects of cytotoxics are modulated by glucocorticoids in human osteosarcoma in vitro.
Robson, H., Meyer, S., Shalet, S. M., Anderson, E., & Eden, O. B. (1999). The anti-tumour effects of cytotoxics are modulated by glucocorticoids in human osteosarcoma in vitro.. Medical and Paediatric Oncology, 33, O42.
Thyroid status affects number and localisation of thyroid hormone receptor expressing mast cells in bone.
Siebler, T., Robson, H., Shalet, S. M., Stevens, D. A., & Williams, G. R. (1999). Thyroid status affects number and localisation of thyroid hormone receptor expressing mast cells in bone.. Journal of Endocrinology, 163, OC20.
1998
Chemotherapeutic agents used in the treatment of childhood malignancies have direct effects on growth plate chondrocyte proliferation.
Robson, H., Anderson, E., Eden, O. B., Isaksson, O., & Shalet, S. (1998). Chemotherapeutic agents used in the treatment of childhood malignancies have direct effects on growth plate chondrocyte proliferation.. Journal of Endocrinology, 157(2), 225-235.
Glucocorticoid pretreatment reduces the cytotoxic effects of a variety of DNA-damaging agents on rat tibial growth-plate chondrocytes in vitro.
Robson, H., Anderson, E., Eden, O., Isaksson, O., & Shalet, S. (1998). Glucocorticoid pretreatment reduces the cytotoxic effects of a variety of DNA-damaging agents on rat tibial growth-plate chondrocytes in vitro.. Cancer Chemotherapy and Pharmacology, 42(2), 171-176.
Growth plate chondrocytes remain responsive to both IGF-1 and GH following treatment with chemotherapeutic agents.
Robson, H., Anderson, E., Eden, O. B., Isaksson, O., & Shalet, S. M. (1998). Growth plate chondrocytes remain responsive to both IGF-1 and GH following treatment with chemotherapeutic agents.. Hormone Research, 50, O33.
Localisation of thyroid hormone receptor (T3R) isoforms alpha and beta1 in rat tibial growth plate cartilage and adjacent bone.
Robson, H., Hasserjian, R. P., Anderson, E., Shalet, S. M., & Williams, G. R. (1998). Localisation of thyroid hormone receptor (T3R) isoforms alpha and beta1 in rat tibial growth plate cartilage and adjacent bone.. Hormone Research, 50, O44.
Thyroid hormone actions on cartilage and bone: interactions with other hormones at the epiphyseal plate and effects on linear growth.
Williams, G. R., Robson, H., & Shalet, S. M. (1998). Thyroid hormone actions on cartilage and bone: interactions with other hormones at the epiphyseal plate and effects on linear growth.. Unknown Journal, 157(3), 391-403.
1997
A comparison of the sensitivity of growth plate chondrocytes in vitro to the glucocorticoids dexamethasone and prednisolone.
Robson, H., Anderson, E., Eden, O. B., Isaksson, O., & Shalet, S. M. (1997). A comparison of the sensitivity of growth plate chondrocytes in vitro to the glucocorticoids dexamethasone and prednisolone.. Hormone Research, 48, P396.
Differential influence of TGFbeta1 and TGFbeta3 isoforms on cell cycle kinetics and postirradiation recovery of normal and malignant colorectal epithelial cells.
Robson, H., Spence, K., Anderson, E., Potten, C. S., & Hendry, J. H. (1997). Differential influence of TGFbeta1 and TGFbeta3 isoforms on cell cycle kinetics and postirradiation recovery of normal and malignant colorectal epithelial cells.. International Journal of Radiation Oncology Biology and Physics, 38(1), 183-190.
1996
Transforming growth factor beta 1 expression in human colorectal tumours: an independent prognostic marker in a subgroup of poor prognosis patients.
Robson, H., Anderson, E., James, R. D., & Schofield, P. F. (1996). Transforming growth factor beta 1 expression in human colorectal tumours: an independent prognostic marker in a subgroup of poor prognosis patients.. British Journal of Cancer, 74(5), 753-758.