Publications
2024
Hepatobiliary circulation and dominant urinary excretion of homogentisic acid in a mouse model of alkaptonuria.
Norman, B. P., Sutherland, H., Wilson, P. J. M., Rutland, D. A., Milan, A. M., Hughes, A. T., . . . Ranganath, L. R. (2024). Hepatobiliary circulation and dominant urinary excretion of homogentisic acid in a mouse model of alkaptonuria.. Journal of inherited metabolic disease, 47(4), 664-673. doi:10.1002/jimd.12728
2023
Bile is a route of excretion for homogentisic acid in alkaptonuria
Conserved and species-specific transcriptional responses to daily programmed resistance exercise in rat and mouse.
Viggars, M. R., Sutherland, H., Cardozo, C. P., & Jarvis, J. C. (2023). Conserved and species-specific transcriptional responses to daily programmed resistance exercise in rat and mouse.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 37(12), e23299. doi:10.1096/fj.202301611r
Conserved and species-specific transcriptional responses to daily programmed resistance exercise in rat and mouse
Skeletal progenitor LRP1-mediated endocytosis is critical for synovial joint formation and bone growth
Adaptation of the transcriptional response to resistance exercise over 4 weeks of daily training
Viggars, M. R., Sutherland, H., Lanmueller, H., Schmoll, M., Bijak, M., & Jarvis, J. C. (2023). Adaptation of the transcriptional response to resistance exercise over 4 weeks of daily training. FASEB JOURNAL, 37(1). doi:10.1096/fj.202201418R
2022
Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria
Norman, B. P., Davison, A. S., Hickton, B., Ross, G. A., Milan, A. M., Hughes, A. T., . . . Ranganath, L. R. (2022). Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria. METABOLITES, 12(10). doi:10.3390/metabo12100927
Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism
Norman, B. P., Davison, A. S., Hughes, J. H., Sutherland, H., Wilson, P. J. M., Berry, N. G., . . . Gallagher, J. A. (2022). Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism. GENES & DISEASES, 9(4), 1129-1142. doi:10.1016/j.gendis.2021.02.007
Impact of Nitisinone on the Cerebrospinal Fluid Metabolome of a Murine Model of Alkaptonuria
Davison, A. S., Norman, B. P., Sutherland, H., Milan, A. M., Gallagher, J. A., Jarvis, J. C., & Ranganath, L. R. (2022). Impact of Nitisinone on the Cerebrospinal Fluid Metabolome of a Murine Model of Alkaptonuria. METABOLITES, 12(6). doi:10.3390/metabo12060477
Altered bone metabolism in the rare inherited disease alkaptonuria
Norman, B. P., Hughes, J. H., Sutherland, H., Wilson, P. J., Ranganath, L. R., Bou-Gharios, G., & Gallagher, J. A. (2022). Altered bone metabolism in the rare inherited disease alkaptonuria. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 103 (pp. A8-A9). Retrieved from https://www.webofscience.com/
Altered bone metabolism in the rare inherited disease alkaptonuria
Norman, B. P., Hughes, J. H., Sutherland, H., Wilson, P. J., Ranganath, L. R., Bou-Gharios, G., & Gallagher, J. A. (2022). Altered bone metabolism in the rare inherited disease alkaptonuria. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 103 (pp. A3). Retrieved from https://www.webofscience.com/
2021
Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with Calcified Cartilage Chondrocytes at Osteochondral Interfaces
Hughes, J. H., Keenan, C. M., Sutherland, H., Edwards, H. R., Wilson, P. J. M., Ranganath, L. R., . . . Gallagher, J. A. (n.d.). Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with Calcified Cartilage Chondrocytes at Osteochondral Interfaces. Calcified Tissue International. doi:10.1007/s00223-020-00764-6
The anatomical distribution of ochronotic pigment in alkaptonuric mice reveals that ageing and mechanical loading make collagen susceptible to chemical attack
Hughes, J. H., Keenan, C. M., Sutherland, H., Edwards, H. R., Ranganath, L. R., Bou-Gharios, G., & Gallagher, J. A. (2021). The anatomical distribution of ochronotic pigment in alkaptonuric mice reveals that ageing and mechanical loading make collagen susceptible to chemical attack. In JOURNAL OF ANATOMY Vol. 238 (pp. 200). Retrieved from https://www.webofscience.com/
2020
Nitisinone causes acquired tyrosinosis in alkaptonuria
Khedr, M., Cooper, M. S., Hughes, A. T., Milan, A. M., Davison, A. S., Norman, B. P., . . . Ranganath, L. R. (2020). Nitisinone causes acquired tyrosinosis in alkaptonuria. JOURNAL OF INHERITED METABOLIC DISEASE, 43(5), 1014-1023. doi:10.1002/jimd.12229
Adaptation of rat fast-twitch muscle to endurance activity is underpinned by changes to protein degradation as well as protein synthesis
Hesketh, S. J., Sutherland, H., Lisboa, P. J., Jarvis, J. C., & Burniston, J. G. (2020). Adaptation of rat fast-twitch muscle to endurance activity is underpinned by changes to protein degradation as well as protein synthesis. FASEB JOURNAL, 34(8), 10398-10417. doi:10.1096/fj.202000668RR
Fractional Synthesis Rates of Individual Proteins in Rat Soleus and Plantaris Muscles
Stead, C. A., Hesketh, S. J., Bennett, S., Sutherland, H., Jarvis, J. C., Lisboa, P. J., & Burniston, J. G. (2020). Fractional Synthesis Rates of Individual Proteins in Rat Soleus and Plantaris Muscles. PROTEOMES, 8(2). doi:10.3390/proteomes8020010
Dietary restriction of tyrosine and phenylalanine lowers tyrosinemia associated with nitisinone therapy of alkaptonuria
Hughes, J. H., Wilson, P. J. M., Sutherland, H., Judd, S., Hughes, A. T., Milan, A. M., . . . Gallagher, J. A. (2020). Dietary restriction of tyrosine and phenylalanine lowers tyrosinemia associated with nitisinone therapy of alkaptonuria. JOURNAL OF INHERITED METABOLIC DISEASE, 43(2), 259-268. doi:10.1002/jimd.12172
2019
Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria
Hughes, J. H., Liu, K., Plagge, A., Wilson, P. J. M., Sutherland, H., Norman, B. P., . . . Bou-Gharios, G. (2019). Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria. Human Molecular Genetics, 28(23), 3928-3939. doi:10.1093/hmg/ddz234
Concentric lamellae - novel microanatomical structures in the articular calcified cartilage of mice
Keenan, C. M., Beckett, A. J., Sutherland, H., Ranganath, L. R., Jarvis, J. C., Prior, I. A., & Gallagher, J. A. (2019). Concentric lamellae - novel microanatomical structures in the articular calcified cartilage of mice. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-47545-2
UBR5 is a novel E3 ubiquitin ligase involved in skeletal muscle hypertrophy and recovery from atrophy
Seaborne, R. A., Hughee, D. C., Turner, D. C., Owens, D. J., Baehr, L. M., Gorski, P., . . . Sharples, A. P. (2019). UBR5 is a novel E3 ubiquitin ligase involved in skeletal muscle hypertrophy and recovery from atrophy. JOURNAL OF PHYSIOLOGY-LONDON, 597(14), 3727-3749. doi:10.1113/JP278073
Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging.
Davison, A. S., Strittmatter, N., Sutherland, H., Hughes, A. T., Hughes, J., Bou-Gharios, G., . . . Gallagher, J. A. (2019). Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging.. Metabolomics : Official journal of the Metabolomic Society, 15(5), 68. doi:10.1007/s11306-019-1531-4
UBR5 is a Novel E3 Ubiquitin Ligase involved in Skeletal Muscle Hypertrophy and Recovery from Atrophy
A Comprehensive LC-QTOF-MS Metabolic Phenotyping Strategy: Application to Alkaptonuria.
Norman, B. P., Davison, A. S., Ross, G. A., Milan, A. M., Hughes, A. T., Sutherland, H., . . . Ranganath, L. R. (2019). A Comprehensive LC-QTOF-MS Metabolic Phenotyping Strategy: Application to Alkaptonuria.. Clinical chemistry. doi:10.1373/clinchem.2018.295345
2018
SpillOver stimulation: A novel hypertrophy model using co-contraction of the plantar-flexors to load the tibial anterior muscle in rats
Schmoll, M., Unger, E., Sutherland, H., Haller, M., Bijak, M., Lanmueller, H., & Jarvis, J. C. (2018). SpillOver stimulation: A novel hypertrophy model using co-contraction of the plantar-flexors to load the tibial anterior muscle in rats. PLOS ONE, 13(11). doi:10.1371/journal.pone.0207886
DISRUPTION OF COLLAGEN TRIPLE HELIX HYDROGEN BONDING IN OCHRONOTIC HUMAN CARTILAGE IN ALKAPTONURIA OBSERVED BY DYNAMIC NUCLEAR POLARISATION-ENHANCED SOLID-STATE NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Norman, B. P., Ying, C. W., Sutherland, H., Wilson, P. J., Roberts, N. B., Duer, M. J., . . . Gallagher, J. A. (2018). DISRUPTION OF COLLAGEN TRIPLE HELIX HYDROGEN BONDING IN OCHRONOTIC HUMAN CARTILAGE IN ALKAPTONURIA OBSERVED BY DYNAMIC NUCLEAR POLARISATION-ENHANCED SOLID-STATE NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S99). doi:10.1016/j.joca.2018.02.214
GENERATION AND PHENOTYPING OF A TARGETED MOUSE MODEL OF ALKAPTONURIA
Hughes, J. H., Liu, K., Sutherland, H., Wilson, P. J., Hughes, A. T., Milan, A. M., . . . Bou-Gharios, G. (2018). GENERATION AND PHENOTYPING OF A TARGETED MOUSE MODEL OF ALKAPTONURIA. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S89-S90). doi:10.1016/j.joca.2018.02.194
2017
In-situ measurements of tensile forces in the tibialis anterior tendon of the rat in concentric, isometric, and resisted co-contractions
Schmoll, M., Unger, E., Sutherland, H., Haller, M., Bijak, M., Lanmueller, H., & Jarvis, J. C. (2017). In-situ measurements of tensile forces in the tibialis anterior tendon of the rat in concentric, isometric, and resisted co-contractions. PHYSIOLOGICAL REPORTS, 5(8). doi:10.14814/phy2.13245
2016
On the Rate of Synthesis of Individual Proteins within and between Different Striated Muscles of the Rat
Hesketh, S., Srisawat, K., Sutherland, H., Jarvis, J., & Burniston, J. (2016). On the Rate of Synthesis of Individual Proteins within and between Different Striated Muscles of the Rat. PROTEOMES, 4(1). doi:10.3390/proteomes4010012
2015
Nitisinone Arrests but Does Not Reverse Ochronosis in Alkaptonuric Mice
Keenan, C. M., Preston, A. J., Sutherland, H., Wilson, P. J., Psarelli, E. E., Cox, T. F., . . . Gallagher, J. A. (2015). Nitisinone Arrests but Does Not Reverse Ochronosis in Alkaptonuric Mice. JIMD REPORTS, VOL 24, 24, 45-50. doi:10.1007/8904_2015_437
2014
Morphological and histological adaptation of muscle and bone to loading induced by repetitive activation of muscle
Vickerton, P., Jarvis, J. C., Gallagher, J. A., Akhtar, R., Sunderland, H., & Jeffery, N. (2014). Morphological and histological adaptation of muscle and bone to loading induced by repetitive activation of muscle. Proceedings of the Royal Society B: Biological Sciences, 281(1788). doi:10.1098/rspb.2014.0786
192. Development of Osteoarthritis in Alkaptonuric Mice
Keenan, C. M., Sutherland, H., Ranganath, L. R., Jarvis, J. C., & Gallagher, J. A. (2014). 192. Development of Osteoarthritis in Alkaptonuric Mice. Rheumatology, 53(suppl_1), i131. doi:10.1093/rheumatology/keu111.001
IDENTIFICATION OF CONCENTRIC LAMELLAE IN THE ARTICULAR CALCIFIED CARTILAGE OF OSTEOARTHRITIC MICE
Keenan, C. M., Beckett, A., Sutherland, H., Prior, I., Ranganath, L. R., Jarvis, J. C., & Gallagher, J. A. (2014). IDENTIFICATION OF CONCENTRIC LAMELLAE IN THE ARTICULAR CALCIFIED CARTILAGE OF OSTEOARTHRITIC MICE. In OSTEOARTHRITIS AND CARTILAGE Vol. 22 (pp. S363-S364). doi:10.1016/j.joca.2014.02.673
DEVELOPMENT OF OSTEOARTHRITIS IN ALKAPTONURIC MICE
Keenan, C. M., Sutherland, H., Ranganath, L. R., Jarvis, J. C., & Gallagher, J. A. (2014). DEVELOPMENT OF OSTEOARTHRITIS IN ALKAPTONURIC MICE. In RHEUMATOLOGY Vol. 53 (pp. 131). Retrieved from https://www.webofscience.com/
Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and its inhibition by nitisinone
Preston, A. J., Keenan, C. M., Sutherland, H., Wilson, P. J., Wlodarski, B., Taylor, A. M., . . . Jarvis, J. C. (2014). Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and its inhibition by nitisinone. ANNALS OF THE RHEUMATIC DISEASES, 73(1), 284-289. doi:10.1136/annrheumdis-2012-202878
2013
Initiation and progression of ochronotic osteoarthropathy in alkaptonuric mice
Keenan, C. M., Preston, A. J., Sutherland, H., Taylor, A. M., Wilson, P. J., Williams, D., . . . Jarvis, J. C. (2013). Initiation and progression of ochronotic osteoarthropathy in alkaptonuric mice. Osteoarthritis and Cartilage, 21, S70-S71. doi:10.1016/j.joca.2013.02.155
2012
Ochronosis in a murine model of alkaptonuria is synonymous to that in the human condition
Taylor, A. M., Preston, A. J., Paulk, N. K., Sutherland, H., Keenan, C. M., Wilson, P. J. M., . . . Jarvis, J. C. (2012). Ochronosis in a murine model of alkaptonuria is synonymous to that in the human condition. OSTEOARTHRITIS AND CARTILAGE, 20(8), 880-886. doi:10.1016/j.joca.2012.04.013
2010
Can you make a sphincter out of skeletal muscle?
Salmons, S., Russold, M., Ramnarine, I., Ashley, Z., Sutherland, H., & Jarvis, J. (2010). Can you make a sphincter out of skeletal muscle?. Physiology News, (Summer 2010), 23-25. doi:10.36866/pn.79.23
Practical and effective stomal sphincter creation: evaluation in pigs.
Russold, M. F., Ramnarine, I., Ashley, Z., Sutherland, H., Salmons, S., & Jarvis, J. C. (2010). Practical and effective stomal sphincter creation: evaluation in pigs.. Diseases of the colon and rectum, 53(4), 467-474. doi:10.1007/dcr.0b013e3181bdbe91
2008
Therapeutic stimulation of denervated muscles: the influence of pattern.
Ashley, Z., Sutherland, H., Russold, M. F., Lanmüller, H., Mayr, W., Jarvis, J. C., & Salmons, S. (2008). Therapeutic stimulation of denervated muscles: the influence of pattern.. Muscle & nerve, 38(1), 875-886. doi:10.1002/mus.21020
2007
Effects of chronic electrical stimulation on long-term denervated muscles of the rabbit hind limb.
Ashley, Z., Salmons, S., Boncompagni, S., Protasi, F., Russold, M., Lanmuller, H., . . . Jarvis, J. C. (2007). Effects of chronic electrical stimulation on long-term denervated muscles of the rabbit hind limb.. Journal of muscle research and cell motility, 28(4-5), 203-217. doi:10.1007/s10974-007-9119-4
Atrophy, but not necrosis, in rabbit skeletal muscle denervated for periods up to one year.
Ashley, Z., Sutherland, H., Lanmüller, H., Russold, M. F., Unger, E., Bijak, M., . . . Jarvis, J. C. (2007). Atrophy, but not necrosis, in rabbit skeletal muscle denervated for periods up to one year.. American journal of physiology. Cell physiology, 292(1), C440-C451. doi:10.1152/ajpcell.00085.2006
2006
Adaptive conditioning of skeletal muscle in a large animal model (Sus domesticus).
Sutherland, H., Salmons, S., Ramnarine, I. R., Capoccia, M., Walsh, A. A., & Jarvis, J. C. (2006). Adaptive conditioning of skeletal muscle in a large animal model (Sus domesticus).. Journal of anatomy, 209(2), 165-177. doi:10.1111/j.1469-7580.2006.00598.x
Counterpulsation from the skeletal muscle ventricle and the intraaortic balloon pump in the normal and failing circulations.
Ramnarine, I. R., Capoccia, M., Ashley, Z., Sutherland, H., Russold, M., Summerfield, N., . . . Jarvis, J. C. (2006). Counterpulsation from the skeletal muscle ventricle and the intraaortic balloon pump in the normal and failing circulations.. Circulation, 114(1 Suppl), I10-I15. doi:10.1161/circulationaha.105.000372
2005
Implantable device for long-term electrical stimulation of denervated muscles in rabbits.
Lanmüller, H., Ashley, Z., Unger, E., Sutherland, H., Reichel, M., Russold, M., . . . Salmons, S. (2005). Implantable device for long-term electrical stimulation of denervated muscles in rabbits.. Medical & biological engineering & computing, 43(4), 535-540. doi:10.1007/bf02344737
Determination of the chronaxie and rheobase of denervated limb muscles in conscious rabbits.
Ashley, Z., Sutherland, H., Lanmuller, H., Unger, E., Li, F., Mayr, W., . . . Salmons, S. (2005). Determination of the chronaxie and rheobase of denervated limb muscles in conscious rabbits.. Artificial organs, 29(3), 212-215. doi:10.1111/j.1525-1594.2005.29037.x
Functional electrical stimulation of denervated muscles: basic issues.
Salmons, S., Ashley, Z., Sutherland, H., Russold, M. F., Li, F., & Jarvis, J. C. (2005). Functional electrical stimulation of denervated muscles: basic issues.. Artificial organs, 29(3), 199-202. doi:10.1111/j.1525-1594.2005.29034.x
2004
A nonradioactive assay for nitric oxide synthase activity in tissue extracts.
Sutherland, H., Zolle, O., Khundkar, R., Simpson, A. W. M., Jarvis, J. C., & Salmons, S. (2004). A nonradioactive assay for nitric oxide synthase activity in tissue extracts.. Methods in molecular biology (Clifton, N.J.), 279, 105-111. doi:10.1385/1-59259-807-2:105
2003
Pattern dependence in the stimulation-induced type transformation of rabbit fast skeletal muscle.
Sutherland, H., Jarvis, J. C., & Salmons, S. (2003). Pattern dependence in the stimulation-induced type transformation of rabbit fast skeletal muscle.. Neuromodulation : journal of the International Neuromodulation Society, 6(3), 176-189. doi:10.1046/j.1525-1403.2003.03025.x
2002
The hemodynamic function of intrathoracic skeletal muscle ventricles after recovery from surgery in pigs.
Capoccia, M., Sutherland, H., Salmons, S., & Jarvis, J. C. (2002). The hemodynamic function of intrathoracic skeletal muscle ventricles after recovery from surgery in pigs.. Artificial organs, 26(3), 235-237. doi:10.1046/j.1525-1594.2002.06940.x
2001
Induction of a fatigue-resistant phenotype in rabbit fast muscle by small daily amounts of stimulation.
Lopez-Guajardo, A., Sutherland, H., Jarvis, J. C., & Salmons, S. (2001). Induction of a fatigue-resistant phenotype in rabbit fast muscle by small daily amounts of stimulation.. Journal of applied physiology (Bethesda, Md. : 1985), 90(5), 1909-1918. doi:10.1152/jappl.2001.90.5.1909
A fluorescence-based method for measuring nitric oxide in extracts of skeletal muscle.
Sutherland, H., Khundkar, R., Zolle, O., McArdle, A., Simpson, A. W., Jarvis, J. C., & Salmons, S. (2001). A fluorescence-based method for measuring nitric oxide in extracts of skeletal muscle.. Nitric oxide : biology and chemistry, 5(5), 475-481. doi:10.1006/niox.2001.0374
2000
Dynamics of stimulation-induced muscle adaptation: insights from varying the duty cycle.
Lopez-Guajardo, A., Sutherland, H., Jarvis, J. C., & Salmons, S. (2000). Dynamics of stimulation-induced muscle adaptation: insights from varying the duty cycle.. Journal of muscle research and cell motility, 21(8), 725-735. doi:10.1023/a:1010353515004
1998
The dose-related response of rabbit fast muscle to long-term low-frequency stimulation.
Sutherland, H., Jarvis, J. C., Kwende, M. M., Gilroy, S. J., & Salmons, S. (1998). The dose-related response of rabbit fast muscle to long-term low-frequency stimulation.. Muscle & nerve, 21(12), 1632-1646. doi:3.0.co;2-w">10.1002/(sici)1097-4598(199812)21:12<1632::aid-mus3>3.0.co;2-w
1996
Fast-to-slow transformation in stimulated rat muscle.
Jarvis, J. C., Mokrusch, T., Kwende, M. M., Sutherland, H., & Salmons, S. (1996). Fast-to-slow transformation in stimulated rat muscle.. Muscle & nerve, 19(11), 1469-1475. doi:3.0.co;2-o">10.1002/(sici)1097-4598(199611)19:11<1469::aid-mus11>3.0.co;2-o
Induction of a fast-oxidative phenotype by chronic muscle stimulation: histochemical and metabolic studies.
Mayne, C. N., Sutherland, H., Jarvis, J. C., Gilroy, S. J., Craven, A. J., & Salmons, S. (1996). Induction of a fast-oxidative phenotype by chronic muscle stimulation: histochemical and metabolic studies.. The American journal of physiology, 270(1 Pt 1), C313-C320. doi:10.1152/ajpcell.1996.270.1.c313
Induction of a fast-oxidative phenotype by chronic muscle stimulation: mechanical and biochemical studies.
Jarvis, J. C., Sutherland, H., Mayne, C. N., Gilroy, S. J., & Salmons, S. (1996). Induction of a fast-oxidative phenotype by chronic muscle stimulation: mechanical and biochemical studies.. The American journal of physiology, 270(1 Pt 1), C306-C312. doi:10.1152/ajpcell.1996.270.1.c306