Publications
Selected publications
- Targeted Inhibition of Aggrecanases Prevents Articular Cartilage Degradation and Augments Bone Mass in the STR/Ort Mouse Model of Spontaneous Osteoarthritis (Journal article - 2019)
- Aggrecan Gene Expression in Chondrocytes is Controlled by Multiple DNA Regulatory Elements. (Conference Paper - 2017)
- Altered Bone Mechanics, Architecture and Composition in the Skeleton of TIMP-3-Deficient Mice. (Journal article - 2017)
- Characterization of Mesenchymal-Fibroblast Cells Using the Col1a2 Promoter/Enhancer. (Journal article - 2017)
- Venous identity requires BMP signalling through ALK3. (Journal article - 2019)
- Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism (Journal article - 2022)
- Syndecan-3 enhances anabolic bone formation through WNT signaling (Journal article - 2021)
- Aggrecanase-selective tissue inhibitor of metalloproteinase-3 (TIMP3) protects articular cartilage in a surgical mouse model of osteoarthritis (Journal article - 2020)
2024
Joint replacement risk is markedly increased in alkaptonuria (AKU) in those with prior arthroplasty
Ranganath, L. R., Khedr, M., Norman, B. P., Hughes, J. H., Imrich, R., Arnoux, J. B., . . . Bou-Gharios, G. (2024). Joint replacement risk is markedly increased in alkaptonuria (AKU) in those with prior arthroplasty. Molecular Genetics and Metabolism Reports, 40, 101097. doi:10.1016/j.ymgmr.2024.101097
Hepatobiliary circulation and dominant urinary excretion of homogentisic acid in a mouse model of alkaptonuria.
Norman, B. P., Sutherland, H., Wilson, P. J. M., Rutland, D. A., Milan, A. M., Hughes, A. T., . . . Ranganath, L. R. (2024). Hepatobiliary circulation and dominant urinary excretion of homogentisic acid in a mouse model of alkaptonuria.. Journal of inherited metabolic disease, 47(4), 664-673. doi:10.1002/jimd.12728
The low-density lipoprotein receptor-related protein 1 regulates non-canonical Wnt signalling and its deficiency causes severe and multiple skeletal defects.
Gremida, A., Wheeler, G., Yamamoto, K., Bou-Gharios, G., Clegg, P., Hof, R. V. T., . . . Maharana, S. (2024). The low-density lipoprotein receptor-related protein 1 regulates non-canonical Wnt signalling and its deficiency causes severe and multiple skeletal defects.. Osteoarthritis and Cartilage, 32(6), 812. doi:10.1016/j.joca.2024.03.078
Tissue- and context-dependent roles of the low-density lipoprotein receptor-related protein 1 in mouse models of osteoarthritis
Yamamoto, K., Gremida, A., Milner, P., Kobayashi, Y., Nagase, H., Hof, R. V. T., & Bou-Gharios, G. (2024). Tissue- and context-dependent roles of the low-density lipoprotein receptor-related protein 1 in mouse models of osteoarthritis. Osteoarthritis and Cartilage, 32(6), 811. doi:10.1016/j.joca.2024.03.077
Collagen fibril formation at the plasma membrane occurs independently from collagen secretion.
Pickard, A., Garva, R., Adamson, A., Calverley, B. C., Hoyle, A., Hayward, C. E., . . . Kadler, K. E. (2024). Collagen fibril formation at the plasma membrane occurs independently from collagen secretion.. bioRxiv. doi:10.1101/2024.05.09.593302
Joint replacement risk is markedly increased in alkaptonuria (AKU) in those with prior arthroplasty
Ranganath, L. R., Khedr, M., Norman, B. P., Hughes, J. H., Imrich, R., Arnoux, J. B., . . . Bou-Gharios, G. (2024). Joint replacement risk is markedly increased in alkaptonuria (AKU) in those with prior arthroplasty. Molecular genetics and metabolism reports, 40.
Expression of semaphorin-3A in the joint and role in osteoarthritis.
Li, X., Martinez-Ramos, S., Heedge, F. T., Pitsillides, A., Bou-Gharios, G., Poulet, B., & Chenu, C. (2024). Expression of semaphorin-3A in the joint and role in osteoarthritis.. Cell Biochem Funct, 42(3), e4012. doi:10.1002/cbf.4012
EXPLOITING ACTIVITY-BASED PROBES TO IDENTIFY SERINE PROTEASE ACTIVITY IN OSTEOARTHRITIS
Hines, M., Wright, M., Bou-Gharios, G., Peffers, M., & Wilkinson, D. J. (2024). EXPLOITING ACTIVITY-BASED PROBES TO IDENTIFY SERINE PROTEASE ACTIVITY IN OSTEOARTHRITIS. Osteoarthritis and Cartilage, 32, S476. doi:10.1016/j.joca.2024.02.707
Cancer-associated Fibroblast-specific Expression of the Matricellular Protein CCN1 Coordinates Neovascularization and Stroma Deposition in Melanoma Metastasis.
Hutchenreuther, J., Nguyen, J., Quesnel, K., Vincent, K. M., Petitjean, L., Bourgeois, S., . . . Leask, A. (2024). Cancer-associated Fibroblast-specific Expression of the Matricellular Protein CCN1 Coordinates Neovascularization and Stroma Deposition in Melanoma Metastasis.. Cancer research communications, 4(2), 556-570. doi:10.1158/2767-9764.crc-23-0571
2023
Bile is a route of excretion for homogentisic acid in alkaptonuria
Skeletal progenitor LRP1-mediated endocytosis is critical for synovial joint formation and bone growth
Evaluation of Homogentisic Acid, a Prospective Antibacterial Agent Highlighted by the Suitability of Nitisinone in Alkaptonuria 2 (SONIA 2) Clinical Trial
Ooi, N., Cooper, I. R., Norman, B., Gallagher, J. A., Sireau, N., Bou-Gharios, G., . . . Savage, V. J. (2023). Evaluation of Homogentisic Acid, a Prospective Antibacterial Agent Highlighted by the Suitability of Nitisinone in Alkaptonuria 2 (SONIA 2) Clinical Trial. CELLS, 12(13). doi:10.3390/cells12131683
Increased prevalence of Parkinson's disease in alkaptonuria
Ranganath, L., Khedr, M., Milan, A. M., Davison, A. S., Norman, B. P., Janssen, M. C. H., . . . Gallagher, J. A. (2023). Increased prevalence of Parkinson's disease in alkaptonuria. JIMD Reports. doi:10.1002/jmd2.12367
305 Matrix metalloproteinase-1 expression in fibroblasts accelerates dermal aging and promotes tumor development in mouse skin
Fisher, G. J., Xia, W., He, T., Bou-Gharios, G., Voorhees, J. J., Dlugosz, A., & Quan, T. (2023). 305 Matrix metalloproteinase-1 expression in fibroblasts accelerates dermal aging and promotes tumor development in mouse skin. Journal of Investigative Dermatology, 143(5), S52. doi:10.1016/j.jid.2023.03.309
ANTIOXIDANT TRANSCRIPTION FACTOR NRF2 REGULATES SKELETAL MUSCLE HOMEOSTASIS THROUGH A CIRCADIAN MECHANISM THAT IS DISRUPTED WITH AGEING
Pekovic-Vaughan, V., Sutton, E., Carter, A., Fawcett, S., Moore, H., Sarumi, D., & Bou-Gharios, G. (2023). ANTIOXIDANT TRANSCRIPTION FACTOR NRF2 REGULATES SKELETAL MUSCLE HOMEOSTASIS THROUGH A CIRCADIAN MECHANISM THAT IS DISRUPTED WITH AGEING. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 201 (pp. 4). doi:10.1016/j.freeradbiomed.2023.03.042
Hereditary Tyrosinemia Type 1 Mice under Continuous Nitisinone Treatment Display Remnants of an Uncorrected Liver Disease Phenotype
Neuckermans, J., Lequeue, S., Claes, P., Heymans, A., Hughes, J. H., Colemonts-Vroninks, H., . . . De Kock, J. (2023). Hereditary Tyrosinemia Type 1 Mice under Continuous Nitisinone Treatment Display Remnants of an Uncorrected Liver Disease Phenotype. GENES, 14(3). doi:10.3390/genes14030693
Matrix Metalloproteinase-1 Expression in Fibroblasts Accelerates Dermal Aging and Promotes Papilloma Development in Mouse Skin.
Quan, T., Xia, W., He, T., Calderone, K., Bou-Gharios, G., Voorhees, J. J., . . . Fisher, G. J. (2023). Matrix Metalloproteinase-1 Expression in Fibroblasts Accelerates Dermal Aging and Promotes Papilloma Development in Mouse Skin.. The Journal of investigative dermatology, S0022-202X(23)01827-4. doi:10.1016/j.jid.2023.02.028
First decade anniversary of the United Kingdom National Alkaptonuria Centre.
Khedr, M., Sireau, N., Bou-Gharios, G., Gallagher, J. A., & Ranganath, L. R. (2023). First decade anniversary of the United Kingdom National Alkaptonuria Centre.. JIMD reports, 64(2), 212-213. doi:10.1002/jmd2.12340
Characterising the relationship between muscle wasting and osteoarthritis in post-traumatic and spontaneous models of osteoarthritis
Shorter, E., Mucci, L. R., Goljanek-Whysall, K., Bou-Gharios, G., & Poulet, B. (2023). Characterising the relationship between muscle wasting and osteoarthritis in post-traumatic and spontaneous models of osteoarthritis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 104 (pp. A16-A17). Retrieved from https://www.webofscience.com/
Increased LANTA31 activates Akt signalling in breast cancer and changes the mode of tumour invasion into laminin matrixes
Asiri, F. M., Troughton, L. D., Zech, T., Bou-Gharios, G., Yamamoto, K., & Hamill, K. J. (2023). Increased LANTA31 activates Akt signalling in breast cancer and changes the mode of tumour invasion into laminin matrixes. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 104 (pp. A10). Retrieved from https://www.webofscience.com/
Interaction of Wnts and low-density lipoprotein receptor-related protein 1 in cartilage development
Gremida, A. M. E., Jensen, A., Alhashmi, M., Mogensen, E. H., Thogersen, I. B., Enghild, J. J., . . . Yamamoto, K. (2023). Interaction of Wnts and low-density lipoprotein receptor-related protein 1 in cartilage development. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 104 (pp. A6-A7). Retrieved from https://www.webofscience.com/
Matrix metalloproteinase-1 expression in fibroblasts accelerates dermal aging and promotes tumor development in mouse skin
Fisher, G. J., Xia, W., He, T., Bou-Gharios, G., Voorhees, J. J., Dlugosz, A., & Quan, T. (2023). Matrix metalloproteinase-1 expression in fibroblasts accelerates dermal aging and promotes tumor development in mouse skin. In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 143 (pp. S52). Retrieved from https://www.webofscience.com/
Targeted inhibition of aggrecanases inhibits the progression of age-dependent cartilage degradation in a temporomandibular joint in the STR/Ort mice
Kobayashi, Y., Yamamoto, K., Kanakis, I., Yamashita, Y., Sakai, T., Jarad, F., . . . Ooi, K. (2023). Targeted inhibition of aggrecanases inhibits the progression of age-dependent cartilage degradation in a temporomandibular joint in the STR/Ort mice. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 104 (pp. A9). Retrieved from https://www.webofscience.com/
Transcriptional elements driving MMP13 in development
AlSalhi, S. I., Alhashmi, M., Young, D., Tew, S., Yamamoto, K., & Bou-Gharios, G. (2023). Transcriptional elements driving MMP13 in development. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 104 (pp. A5). Retrieved from https://www.webofscience.com/
2022
MEF2 transcription factors are key regulators of sprouting angiogenesis (vol 30, pg 2297, 2016)
Sacilotto, N., Chouliaras, K. M., Nikitenko, L. L., Lu, Y. W., Fritzsche, M., Wallace, M. D., . . . De Val, S. (2022). MEF2 transcription factors are key regulators of sprouting angiogenesis (vol 30, pg 2297, 2016). GENES & DEVELOPMENT, 36(19-20), 1096. doi:10.1101/gad.350249.122
Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria
Norman, B. P., Davison, A. S., Hickton, B., Ross, G. A., Milan, A. M., Hughes, A. T., . . . Ranganath, L. R. (2022). Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria. METABOLITES, 12(10). doi:10.3390/metabo12100927
Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria
Ranganath, L. R., Hughes, A. T., Davison, A. S., Khedr, M., Imrich, R., Rudebeck, M., . . . Milan, A. M. (2022). Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria. METABOLITES, 12(10). doi:10.3390/metabo12100920
Determinants of tyrosinaemia during nitisinone therapy in alkaptonuria
Ranganath, L. R., Milan, A. M., Hughes, A. T., Davison, A. S., Khedr, M., Norman, B. P., . . . Olsson, B. (2022). Determinants of tyrosinaemia during nitisinone therapy in alkaptonuria. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-20424-z
Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice
Lee, K. J., Rambault, L., Bou-Gharios, G., Clegg, P. D., Akhtar, R., Czanner, G., . . . Canty-Laird, E. G. (2022). Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice. DISEASE MODELS & MECHANISMS, 15(9). doi:10.1242/dmm.049428
A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage.
Yamamoto, K., Scavenius, C., Meschis, M. M., Gremida, A. M. E., Mogensen, E. H., Thøgersen, I. B., . . . Nagase, H. (2022). A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage.. Matrix biology : journal of the International Society for Matrix Biology, S0945-053X(22)00101-9. doi:10.1016/j.matbio.2022.08.007
Comparing the Phenylalanine/Tyrosine Pathway and Related Factors between Keratopathy and No-Keratopathy Groups as Well as between Genders in Alkaptonuria during Nitisinone Treatment
Ranganath, L. R., Milan, A. M., Hughes, A. T., Davison, A. S., Khedr, M., Imrich, R., . . . Gallagher, J. A. (2022). Comparing the Phenylalanine/Tyrosine Pathway and Related Factors between Keratopathy and No-Keratopathy Groups as Well as between Genders in Alkaptonuria during Nitisinone Treatment. METABOLITES, 12(8). doi:10.3390/metabo12080772
MiR-18a-5p Targets Connective Tissue Growth Factor Expression and Inhibits Transforming Growth Factor β2-Induced Trabecular Meshwork Cell Contractility
Knox, J., Bou-Gharios, G., Hamill, K. J., & Willoughby, C. E. (2022). MiR-18a-5p Targets Connective Tissue Growth Factor Expression and Inhibits Transforming Growth Factor β2-Induced Trabecular Meshwork Cell Contractility. GENES, 13(8). doi:10.3390/genes13081500
Cartilage debris and osteoarthritis risk factors influence gene expression in the synovium in end stage osteoarthritis
Roebuck, M. M., Jamal, J., Lane, B., Wood, A., Santini, A., Wong, P. -F., . . . Frostick, S. P. (2022). Cartilage debris and osteoarthritis risk factors influence gene expression in the synovium in end stage osteoarthritis. KNEE, 37, 47-59. doi:10.1016/j.knee.2022.05.001
Laminin N-terminus α31 expression during development is lethal and causes widespread tissue-specific defects in a transgenic mouse model
Sugden, C. J., Iorio, V., Troughton, L. D., Liu, K., Morais, M. R. P. T., Lennon, R., . . . Hamill, K. J. (2022). Laminin N-terminus α31 expression during development is lethal and causes widespread tissue-specific defects in a transgenic mouse model. FASEB JOURNAL, 36(7). doi:10.1096/fj.202002588RRR
Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism
Norman, B. P., Davison, A. S., Hughes, J. H., Sutherland, H., Wilson, P. J. M., Berry, N. G., . . . Gallagher, J. A. (2022). Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism. GENES & DISEASES, 9(4), 1129-1142. doi:10.1016/j.gendis.2021.02.007
Histopathological dataset and demographic details of synovial tissues from patients with end-stage osteoarthritis, soft tissue and traumatic injuries of the knee
Jamal, J., Roebuck, M. M., Wood, A., Santini, A., Bou-Gharios, G., Frostick, S. P., & Wong, P. -F. (2022). Histopathological dataset and demographic details of synovial tissues from patients with end-stage osteoarthritis, soft tissue and traumatic injuries of the knee. DATA IN BRIEF, 42. doi:10.1016/j.dib.2022.108082
Temporal adaptations in the phenylalanine/tyrosine pathway and related factors during nitisinone-induced tyrosinaemia in alkaptonuria.
Ranganath, L. R., Hughes, A. T., Davison, A. S., Khedr, M., Olsson, B., Rudebeck, M., . . . Milan, A. M. (2022). Temporal adaptations in the phenylalanine/tyrosine pathway and related factors during nitisinone-induced tyrosinaemia in alkaptonuria.. Molecular genetics and metabolism, S1096-7192(22)00325-0. doi:10.1016/j.ymgme.2022.05.006
The anterior cruciate ligament in murine post-traumatic osteoarthritis: markers and mechanics
Ramos-Mucci, L., Elsheikh, A., Keenan, C., Eliasy, A., D'Aout, K., Bou-Gharios, G., . . . Poulet, B. (2022). The anterior cruciate ligament in murine post-traumatic osteoarthritis: markers and mechanics. ARTHRITIS RESEARCH & THERAPY, 24(1). doi:10.1186/s13075-022-02798-7
Metabolomic analysis of bone resorption in vitro provides new insights into osteoclastic action and reveals novel biomarkers
Norman, B., Dillon, J., Bou-Gharios, G., Ranganath, L., & Gallagher, J. (2022). Metabolomic analysis of bone resorption in vitro provides new insights into osteoclastic action and reveals novel biomarkers. Bone Reports, 16, 101401. doi:10.1016/j.bonr.2022.101401
Uncovering the ligandome of low-density lipoprotein receptor-related protein 1 in cartilage: a top-down approach to identify therapeutic targets
Characterization of changes in the tyrosine pathway by 24-h profiling during nitisinone treatment in alkaptonuria
Ranganath, L. R., Milan, A. M., Hughes, A. T., Davison, A. S., Khedr, M., Norman, B. P., . . . Olsson, B. (2022). Characterization of changes in the tyrosine pathway by 24-h profiling during nitisinone treatment in alkaptonuria. Molecular Genetics and Metabolism Reports, 30, 100846. doi:10.1016/j.ymgmr.2022.100846
Altered bone metabolism in the rare inherited disease alkaptonuria
Norman, B. P., Hughes, J. H., Sutherland, H., Wilson, P. J., Ranganath, L. R., Bou-Gharios, G., & Gallagher, J. A. (2022). Altered bone metabolism in the rare inherited disease alkaptonuria. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 103 (pp. A3). Retrieved from https://www.webofscience.com/
Altered bone metabolism in the rare inherited disease alkaptonuria
Norman, B. P., Hughes, J. H., Sutherland, H., Wilson, P. J., Ranganath, L. R., Bou-Gharios, G., & Gallagher, J. A. (2022). Altered bone metabolism in the rare inherited disease alkaptonuria. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 103 (pp. A8-A9). Retrieved from https://www.webofscience.com/
CHARACTERIZING MANUFACTURED THERAPEUTIC CHONDROCYTES USING PROGNOSTIC BIOACTIVITY MARKERS
Al-Maslamani, N., Curran, J., Hoettges, K., Bou-Gharios, G., & Henstock, J. (2022). CHARACTERIZING MANUFACTURED THERAPEUTIC CHONDROCYTES USING PROGNOSTIC BIOACTIVITY MARKERS. In TISSUE ENGINEERING PART A Vol. 28 (pp. S116-S117). Retrieved from https://www.webofscience.com/
2021
NRF2/KEAP1 pathway is required to fine-tune circadian oscillations as part of the negative feedback loop of the molecular clock: implications for tissue homeostasis and therapeutic interventions
Sutton, E., Early, J., Hughes, A., Gall, L., Carter, A., Copple, I., . . . Pekovic-Vaughan, V. (2021). NRF2/KEAP1 pathway is required to fine-tune circadian oscillations as part of the negative feedback loop of the molecular clock: implications for tissue homeostasis and therapeutic interventions. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 177. doi:10.1016/j.freeradbiomed.2021.08.042
Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis
Yamamoto, K., Wilkinson, D., & Bou-Gharios, G. (n.d.). Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis. Calcified Tissue International. doi:10.1007/s00223-020-00739-7
Selective deletion of connective tissue growth factor attenuates experimentally-induced pulmonary fibrosis and pulmonary arterial hypertension
Tam, A. Y. Y., Horwell, A. L., Trinder, S. L., Khan, K., Xu, S., Ong, V., . . . Abraham, D. J. (2021). Selective deletion of connective tissue growth factor attenuates experimentally-induced pulmonary fibrosis and pulmonary arterial hypertension. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 134. doi:10.1016/j.biocel.2021.105961
Dermal Fibroblast <i>CCN1</i> Expression in Mice Recapitulates Human Skin Dermal Aging
Quan, T., Xiang, Y., Liu, Y., Qin, Z., Yang, Y., Bou-Gharios, G., . . . Fisher, G. J. (2021). Dermal Fibroblast <i>CCN1</i> Expression in Mice Recapitulates Human Skin Dermal Aging. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 141(4), 1007-1016. doi:10.1016/j.jid.2020.07.019
FHL2 promoter DNA methylation increases with chronological age in joint tissues and impacts target gene expression
Fulea, R. C., Reynard, L., Young, D., & Bou-Gharios, G. (2021). FHL2 promoter DNA methylation increases with chronological age in joint tissues and impacts target gene expression. Osteoarthritis and Cartilage, 29, S310. doi:10.1016/j.joca.2021.02.409
Syndecan-3 enhances anabolic bone formation through WNT signaling
Johnson de Sousa Brito, F. M., Butcher, A., Pisconti, A., Poulet, B., Prior, A., Charlesworth, G., . . . Daroszewska, A. (2021). Syndecan-3 enhances anabolic bone formation through WNT signaling. FASEB JOURNAL, 35(4). doi:10.1096/fj.202002024R
Expression of tyrosine pathway enzymes in mice demonstrates that homogentisate 1,2-dioxygenase deficiency in the liver is responsible for homogentisic acid-derived ochronotic pigmentation.
Wilson, P. J. M., Ranganath, L. R., Bou-Gharios, G., Gallagher, J. A., & Hughes, J. H. (2021). Expression of tyrosine pathway enzymes in mice demonstrates that homogentisate 1,2-dioxygenase deficiency in the liver is responsible for homogentisic acid-derived ochronotic pigmentation.. JIMD reports, 58(1), 52-60. doi:10.1002/jmd2.12184
Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with Calcified Cartilage Chondrocytes at Osteochondral Interfaces
Hughes, J. H., Keenan, C. M., Sutherland, H., Edwards, H. R., Wilson, P. J. M., Ranganath, L. R., . . . Gallagher, J. A. (n.d.). Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with Calcified Cartilage Chondrocytes at Osteochondral Interfaces. Calcified Tissue International. doi:10.1007/s00223-020-00764-6
<i>FHL2</i> PROMOTER DNA METHYLATION INCREASES WITH CHRONOLOGICAL AGE IN JOINT TISSUES AND IMPACTS TARGET GENE EXPRESSION
Fulea, R. C., Reynard, L., Young, D., & Bou-Gharios, G. (2021). <i>FHL2</i> PROMOTER DNA METHYLATION INCREASES WITH CHRONOLOGICAL AGE IN JOINT TISSUES AND IMPACTS TARGET GENE EXPRESSION. In OSTEOARTHRITIS AND CARTILAGE Vol. 29 (pp. S310). Retrieved from https://www.webofscience.com/
<i>FHL2</i> promoter DNA methylation increases with chronological age in joint tissues and could impact target gene expression
Fulea, R. C., Young, D. A., Bou-Gharios, G., & Reynard, L. N. (2021). <i>FHL2</i> promoter DNA methylation increases with chronological age in joint tissues and could impact target gene expression. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 102 (pp. 132-133). Retrieved from https://www.webofscience.com/
Cartilage-Specific Cre Recombinase Transgenes/Alleles in the Mouse
Kanakis, I., Alhashmi, M., Liu, K., Keenan, C., Mucci, L. R., Poulet, B., & Bou-Gharios, G. (2021). Cartilage-Specific Cre Recombinase Transgenes/Alleles in the Mouse. In CHONDROCYTES (Vol. 2245, pp. 23-38). doi:10.1007/978-1-0716-1119-7_3
Metalloelastase-12 is involved in the temporomandibular joint inflammatory response as well as cartilage degradation by aggrecanases in STR/Ort mice
Yamashita-Futani, Y., Jokaji, R., Ooi, K., Kobayashi, K., Kanakis, I., Liu, K., . . . Nakamura, H. (2021). Metalloelastase-12 is involved in the temporomandibular joint inflammatory response as well as cartilage degradation by aggrecanases in STR/Ort mice. BIOMEDICAL REPORTS, 14(6). doi:10.3892/br.2021.1427
Short term exposure to physiologically relevant levels of interleukin 1β initiate sustained changes in chondrocyte
Horne, R., Bou-Gharios, G., Young, D., & Tew, S. (2021). Short term exposure to physiologically relevant levels of interleukin 1β initiate sustained changes in chondrocyte. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 102 (pp. 131-132). Retrieved from https://www.webofscience.com/
The anatomical distribution of ochronotic pigment in alkaptonuric mice reveals that ageing and mechanical loading make collagen susceptible to chemical attack
Hughes, J. H., Keenan, C. M., Sutherland, H., Edwards, H. R., Ranganath, L. R., Bou-Gharios, G., & Gallagher, J. A. (2021). The anatomical distribution of ochronotic pigment in alkaptonuric mice reveals that ageing and mechanical loading make collagen susceptible to chemical attack. In JOURNAL OF ANATOMY Vol. 238 (pp. 200). Retrieved from https://www.webofscience.com/
\ Fibroblast-specific deletion of cell-surface endocytic receptor LRP1 prevents the development of pulmonary fibrosis in mouse in vivo
Meschis, M. M., Scavenius, C., Enghild, J. J., Craig, S., Bou-Gharios, G., & Yamamoto, K. (2021). \ Fibroblast-specific deletion of cell-surface endocytic receptor LRP1 prevents the development of pulmonary fibrosis in mouse in vivo. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 102 (pp. A14). Retrieved from https://www.webofscience.com/
2020
Syndecan 3 stimulates bone formation through stabilisation of Frizzled 1
Butcher, A., Charlesworth, G., Prior, A., Sperinck, K., Pisconti, A., Bou-Gharios, G., . . . Van ’THof, R. (2020). Syndecan 3 stimulates bone formation through stabilisation of Frizzled 1. Bone Reports, 13, 100441. doi:10.1016/j.bonr.2020.100441
Modulation of the mechanical responses of synovial fibroblasts by osteoarthritis-associated inflammatory stressors.
Jamal, J., Roebuck, M. M., Lee, S. -Y., Frostick, S. P., Abbas, A. A., Merican, A. M., . . . Wong, P. -F. (2020). Modulation of the mechanical responses of synovial fibroblasts by osteoarthritis-associated inflammatory stressors.. The International Journal of Biochemistry and Cell Biology, 126. doi:10.1016/j.biocel.2020.105800
Laminin N-terminus α31 expression during development is lethal and causes widespread tissue-specific defects in a transgenic mouse model
Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis
Ramos-Mucci, L., Javaheri, B., van ‘t Hof, R., Bou-Gharios, G., Pitsillides, A. A., Comerford, E., & Poulet, B. (n.d.). Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis. Arthritis Research & Therapy, 22(1). doi:10.1186/s13075-020-02261-5
Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice
Lee, K., Rambault, L., Bou-Gharios, G., Clegg, P., Akhtar, R., Czanner, G., . . . Canty-Laird, E. (2020). Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice. doi:10.1101/2020.07.13.198283
Post-traumatic osteoarthritis development is not modified by postnatal chondrocyte deletion of <i>Ccn2</i>
Keenan, C. M., Ramos-Mucci, L., Kanakis, I., Milner, P. I., Leask, A., Abraham, D., . . . Poulet, B. (2020). Post-traumatic osteoarthritis development is not modified by postnatal chondrocyte deletion of <i>Ccn2</i>. DISEASE MODELS & MECHANISMS, 13(7). doi:10.1242/dmm.044719
Aggrecanase-selective tissue inhibitor of metalloproteinase-3 (TIMP3) protects articular cartilage in a surgical mouse model of osteoarthritis
Nakamura, H., Phoung, V., Kanakis, I., Liu, K., & Bou-Gharios, G. (2020). Aggrecanase-selective tissue inhibitor of metalloproteinase-3 (TIMP3) protects articular cartilage in a surgical mouse model of osteoarthritis. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-66233-0
Injected human umbilical cord-derived mesenchymal stromal cells do not appear to elicit an inflammatory response in a murine model of osteoarthritis.
Perry, J., McCarthy, H. S., Bou-Gharios, G., van 't Hof, R., Milner, P. I., Mennan, C., & Roberts, S. (2020). Injected human umbilical cord-derived mesenchymal stromal cells do not appear to elicit an inflammatory response in a murine model of osteoarthritis.. Osteoarthritis and cartilage open, 2(2), 100044. doi:10.1016/j.ocarto.2020.100044
SIRT1 directly activates autophagy in human chondrocytes
Sacitharan, P. K., Bou-Gharios, G., & Edwards, J. R. (2020). SIRT1 directly activates autophagy in human chondrocytes. Cell Death Discovery, 6(1). doi:10.1038/s41420-020-0277-0
SEMAPHORIN-3A EXPRESSION IS UP-REGULATED IN INNERVATED JOINT TISSUES DURING THE DEVELOPMENT OF OSTEOARTHRITIS
Li, X., Ter Heegde, F., Javaheri, B., Pitsillides, A., Bou-Gharios, G., & Chenu, C. (2020). SEMAPHORIN-3A EXPRESSION IS UP-REGULATED IN INNERVATED JOINT TISSUES DURING THE DEVELOPMENT OF OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 28 (pp. S199). Retrieved from https://www.webofscience.com/
Dietary restriction of tyrosine and phenylalanine lowers tyrosinemia associated with nitisinone therapy of alkaptonuria
Hughes, J. H., Wilson, P. J. M., Sutherland, H., Judd, S., Hughes, A. T., Milan, A. M., . . . Gallagher, J. A. (2020). Dietary restriction of tyrosine and phenylalanine lowers tyrosinemia associated with nitisinone therapy of alkaptonuria. JOURNAL OF INHERITED METABOLIC DISEASE, 43(2), 259-268. doi:10.1002/jimd.12172
Post-traumatic osteoarthritis development is not modified by postnatal chondrocyte deletion of CCN2
Chapter 13 Type I collagen structure, synthesis, and regulation
Bou-Gharios, G., Abraham, D., & de Crombrugghe, B. (2020). Chapter 13 Type I collagen structure, synthesis, and regulation. In Principles of Bone Biology (pp. 295-337). Elsevier. doi:10.1016/b978-0-12-814841-9.00013-0
Development and validation of an inducible LaNt α31 overexpressing mouse model
Sugden, C. J., Troughton, L. D., Liu, K., Bou-Gharios, G., & Hamill, K. J. (2020). Development and validation of an inducible LaNt α31 overexpressing mouse model. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 101 (pp. A5). Retrieved from https://www.webofscience.com/
Endocytosis of extracellular molecules in respiratory health and disease
Meschis, M. M., Scavenius, C., Enghild, J. J., Craig, S., Bou-Gharios, G., & Yamamoto, K. (2020). Endocytosis of extracellular molecules in respiratory health and disease. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 101 (pp. A3). Retrieved from https://www.webofscience.com/
2019
The contribution of mouse models in the rare disease alkaptonuria
Hughes, J. H., Bou-Gharios, G., Ranganath, L. R., & Gallagher, J. A. (2019). The contribution of mouse models in the rare disease alkaptonuria. Drug Discovery Today: Disease Models. doi:10.1016/j.ddmod.2019.10.005
Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria
Hughes, J. H., Liu, K., Plagge, A., Wilson, P. J. M., Sutherland, H., Norman, B. P., . . . Bou-Gharios, G. (2019). Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria. Human Molecular Genetics, 28(23), 3928-3939. doi:10.1093/hmg/ddz234
Syndecan-3 enhances anabolic bone formation through WNT signalling
Johnson de Sousa Brito, F. M., Butcher, A., Pisconti, A., Poulet, B., Prior, A., Charlesworth, G., . . . Daroszewska, A. (2019). Syndecan-3 enhances anabolic bone formation through WNT signalling. doi:10.1101/846972
Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis
Matrix-degrading protease ADAMTS-5 cleaves inter-α-inhibitor and releases active heavy chain 2 in synovial fluids from arthritic patients
Scavenius, C., Poulsen, E. C., Thøgersen, I. B., Roebuck, M., Frostick, S., Bou-Gharios, G., . . . Enghild, J. J. (2019). Matrix-degrading protease ADAMTS-5 cleaves inter-α-inhibitor and releases active heavy chain 2 in synovial fluids from arthritic patients. Journal of Biological Chemistry, 294(42), 15495-15504. doi:10.1074/jbc.ra119.008844
Selectively high efficacy of eribulin against high-grade invasive recurrent and/or metastatic squamous cell carcinoma of the head and neck
Kobayashi, Y., Kitahara, H., Hirai, M., Tanaka, A., Jokaji, R., Kobayashi, K., . . . Kawashiri, S. (2019). Selectively high efficacy of eribulin against high-grade invasive recurrent and/or metastatic squamous cell carcinoma of the head and neck. ONCOLOGY LETTERS, 17(6), 5064-5072. doi:10.3892/ol.2019.10165
Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging (vol 15, 68, 2019)
Davison, A. S., Strittmatter, N., Sutherland, H., Hughes, A. T., Hughes, J., Bou-Gharios, G., . . . Gallagher, J. A. (2019). Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging.. Metabolomics : Official journal of the Metabolomic Society, 15(5), 68. doi:10.1007/s11306-019-1531-4
CHONDROCYTE SPECIFIC EXPRESSION OF CCN2 DOES NOT MODIFY OSTEOARTHRITIS DEVELOPMENT IN MICE
Keenan, C., Ramos, L., Kanakis, I., Milner, P., Abraham, D., Bou-Gharios, G., & Poulet, B. (2019). CHONDROCYTE SPECIFIC EXPRESSION OF CCN2 DOES NOT MODIFY OSTEOARTHRITIS DEVELOPMENT IN MICE. In OSTEOARTHRITIS AND CARTILAGE Vol. 27 (pp. S162). doi:10.1016/j.joca.2019.02.240
HUMAN UMBILICAL CORD MESENCHYMAL STROMAL CELLS DO NOT EVOKE AN IMMUNE RESPONSE IN THE PARTIAL MEDIAL MENISCECTOMY MURINE MODEL OF OSTEOARTHRITIS
Perry, J., Mennan, C., McCarthy, H. S., Bou-Gharios, G., van 't Hof, R., Milner, P., . . . Roberts, S. (2019). HUMAN UMBILICAL CORD MESENCHYMAL STROMAL CELLS DO NOT EVOKE AN IMMUNE RESPONSE IN THE PARTIAL MEDIAL MENISCECTOMY MURINE MODEL OF OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 27 (pp. S438-S439). doi:10.1016/j.joca.2019.02.468
Targeted Inhibition of Aggrecanases Prevents Articular Cartilage Degradation and Augments Bone Mass in the STR/Ort Mouse Model of Spontaneous Osteoarthritis
Kanakis, I., Liu, K., Poulet, B., Javaheri, B., van 't Hof, R. J., Pitsillides, A. A., & Bou-Gharios, G. (2019). Targeted Inhibition of Aggrecanases Prevents Articular Cartilage Degradation and Augments Bone Mass in the STR/Ort Mouse Model of Spontaneous Osteoarthritis. Arthritis and Rheumatology, 71(4), 571-582. doi:10.1002/art.40765
Venous identity requires BMP signalling through ALK3.
Neal, A., Nornes, S., Payne, S., Wallace, M. D., Fritzsche, M., Louphrasitthiphol, P., . . . De Val, S. (2019). Venous identity requires BMP signalling through ALK3.. Nature communications, 10(1), 453. doi:10.1038/s41467-019-08315-w
Effects of Fibrillin-1 mutation (Tight skin mouse) in joint health
Keenan, C., Ramos, L., Smith, H., Ramanayake, W., Andrew, P., Bou-Gharios, G., . . . Blandine, P. (2019). Effects of Fibrillin-1 mutation (Tight skin mouse) in joint health. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A22). Retrieved from https://www.webofscience.com/
The miRNA miR-21a-5p targets SMAD7, and its inhibition decreases lung fibrosis in the mouse
di Mase, M. S., Whysall, K., Bou-Gharios, G., & Van't Hof, R. (2019). The miRNA miR-21a-5p targets SMAD7, and its inhibition decreases lung fibrosis in the mouse. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A33-A34). Retrieved from https://www.webofscience.com/
Type I collagen structure, synthesis, and regulation
Bou-Gharios, G., Abraham, D., & de Crombrugghe, B. (2020). Type I collagen structure, synthesis, and regulation. In Principles of Bone Biology (pp. 295-337). Elsevier. doi:10.1016/b978-0-12-814841-9.00013-0
2018
Targeted inhibition of aggrecanases prevents articular cartilage degradation and augments bone mass in the STR/Ort spontaneous model of osteoarthritis.
Bou-Gharios, G. (n.d.). Targeted inhibition of aggrecanases prevents articular cartilage degradation and augments bone mass in the STR/Ort spontaneous model of osteoarthritis.. Arthritis and Rheumatology.
Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300
Sacitharan, P. K., Lwin, S., Gharios, G. B., & Edwards, J. R. (2018). Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300. EXPERIMENTAL AND MOLECULAR MEDICINE, 50. doi:10.1038/s12276-018-0149-3
The Chondro-Osseous Continuum: Is It Possible to Unlock the Potential Assigned Within?
Javaheri, B., Caetano-Silva, S. P., Kanakis, I., Bou-Gharios, G., & Pitsillides, A. A. (2018). The Chondro-Osseous Continuum: Is It Possible to Unlock the Potential Assigned Within?. Frontiers in Bioengineering and Biotechnology, 6. doi:10.3389/fbioe.2018.00028
Multiple enhancer regions govern the transcription of CCN2 during embryonic development
Frost, S. L., Liu, K., Li, I. M. H., Poulet, B., Comerford, E., De Val, S., & Bou-Gharios, G. (2018). Multiple enhancer regions govern the transcription of CCN2 during embryonic development. JOURNAL OF CELL COMMUNICATION AND SIGNALING, 12(1), 231-243. doi:10.1007/s12079-017-0440-4
Chondrocyte specific deletion of CCN2 does not exacerbate osteoarthritis in models of post-traumatic osteoarthritis in mice
Keenan, C., Jaffa, M., Milner, P., Kanakis, I., Carter, A., Abraham, D., . . . Poulet, B. (2018). Chondrocyte specific deletion of CCN2 does not exacerbate osteoarthritis in models of post-traumatic osteoarthritis in mice. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A14). Retrieved from https://www.webofscience.com/
Murine cruciate ligament pathology and mechanics during osteoarthritis development
Ramos, L., Bou-Gharios, G., Pitsillides, A. A., Comerford, E., & Poulet, B. (2018). Murine cruciate ligament pathology and mechanics during osteoarthritis development. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A63-A64). Retrieved from https://www.webofscience.com/
The effect of [-1A]TIMP3 overexpression on bone mass in the naturally developing OA STR/Ort mice
Kanakis, I., van't Hof, R., Liu, K., Pitsillides, A., & Bou-Gharios, G. (2018). The effect of [-1A]TIMP3 overexpression on bone mass in the naturally developing OA STR/Ort mice. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A17-A18). Retrieved from https://www.webofscience.com/
Ubiquitous removal of ccn2 in a bleomycin induced pulmonary fibrosis model is detrimental to survival
Horwell, A. L., Liu, K., Spencer, L., Moots, R., Van 'T Hof, R., & Bou-Gharios, G. (2018). Ubiquitous removal of ccn2 in a bleomycin induced pulmonary fibrosis model is detrimental to survival. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A40-A41). Retrieved from https://www.webofscience.com/
2017
Aggrecan Gene Expression in Chondrocytes is Controlled by Multiple DNA Regulatory Elements.
Li, I. M. H., Liu, K., Neal, A., Clegg, P. D., De Val, S., & Bou-Gharios, G. (2017). Aggrecan Gene Expression in Chondrocytes is Controlled by Multiple DNA Regulatory Elements.. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 32 (pp. S314). Retrieved from https://www.webofscience.com/
Characterization of Mesenchymal-Fibroblast Cells Using the Col1a2 Promoter/Enhancer.
Li, I. M. H., Horwell, A. L., Chu, G., de Crombrugghe, B., & Bou-Gharios, G. (2017). Characterization of Mesenchymal-Fibroblast Cells Using the Col1a2 Promoter/Enhancer.. Methods in molecular biology (Clifton, N.J.), 1627, 139-161. doi:10.1007/978-1-4939-7113-8_10
SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development
Chiang, I. K. -N., Fritzsche, M., Pichol-Thievend, C., Neal, A., Holmes, K., Lagendijk, A., . . . Francois, M. (2017). SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development, 144(14), 2629-2639. doi:10.1242/dev.146241
Altered Bone Mechanics, Architecture and Composition in the Skeleton of TIMP-3-Deficient Mice.
Miller, B., Spevak, L., Lukashova, L., Javaheri, B., Pitsillides, A. A., Boskey, A., . . . Carriero, A. (2017). Altered Bone Mechanics, Architecture and Composition in the Skeleton of TIMP-3-Deficient Mice. CALCIFIED TISSUE INTERNATIONAL, 100(6), 631-640. doi:10.1007/s00223-017-0248-5
Murine cruciate ligament degeneration and marker expression during osteoarthritis
Ramos, L. D., Bou-Gharios, G., Pitsillides, A. A., Comerford, E., & Poulet, B. (2017). Murine cruciate ligament degeneration and marker expression during osteoarthritis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 98 (pp. A8-A9). Retrieved from https://www.webofscience.com/
2016
Overexpression of TIMP-3 in chondrocytes produces transient reduction in growth plate length but permanently reduces adult bone quality and quantity
Poulet, B., Liu, K., Plumb, D., Vo, P., Shah, M., Staines, K., . . . Bou-Gharios, G. (2016). Overexpression of TIMP-3 in chondrocytes produces transient reduction in growth plate length but permanently reduces adult bone quality and quantity. PLoS ONE, 11(12). doi:10.1371/journal.pone.0167971
Aggrecan gene expression in chondrocytes is controlled by multiple regulatory elements
Li, I. M., Liu, K., Neal, A., Clegg, P. D., De Val, S., & Bou-Gharios, G. (2016). Aggrecan gene expression in chondrocytes is controlled by multiple regulatory elements. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A8-A9). Retrieved from https://www.webofscience.com/
Chondrocyte-specific TIMP3 overexpression disrupts endochondral growth and compromises bone structure and integrity: functional impact of the chondrocyte-to-osteoblast lineage
Poulet, B., Liu, K., Plumb, D., Vo, P., Shah, M., Staines, K., . . . Carrierro, A. (2016). Chondrocyte-specific TIMP3 overexpression disrupts endochondral growth and compromises bone structure and integrity: functional impact of the chondrocyte-to-osteoblast lineage. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A7). Chester. doi:10.1111/iep.12211
Eribulin sensitizes oral squamous cell carcinoma cells to cetuximab via induction of mesenchymal-to-epithelial transition
Kitahara, H., Hirai, M., Kato, K., Bou-Gharios, G., Nakamura, H., & Kawashiri, S. (2016). Eribulin sensitizes oral squamous cell carcinoma cells to cetuximab via induction of mesenchymal-to-epithelial transition. ONCOLOGY REPORTS, 36(6), 3139-3144. doi:10.3892/or.2016.5189
Investigating the role of the RNA binding protein HuR during chondrogenesis
Johnson, K. A., McDermott, B. T., Milner, P. I., Bou-Gharios, G., & Tew, S. R. (2016). Investigating the role of the RNA binding protein HuR during chondrogenesis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A23). Retrieved from https://www.webofscience.com/
MEF2 transcription factors are key regulators of sprouting angiogenesis
Sacilotto, N., Chouliaras, K. M., Nikitenko, L. L., Lu, Y. W., Fritzsche, M., Wallace, M. D., . . . De Val, S. (2016). MEF2 transcription factors are key regulators of sprouting angiogenesis. GENES & DEVELOPMENT, 30(20), 2297-2309. doi:10.1101/gad.290619.116
Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sections
Ikeda, T., Fragiadaki, M., Xu, S. -W., Ponticos, M., Khan, K., Denton, C., . . . Abraham, D. (2016). Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sections. DATA IN BRIEF, 8, 1377-1380. doi:10.1016/j.dib.2016.08.014
Transforming growth factor-<i>β</i>-induced CUX1 isoforms are associated with fibrosis in systemic sclerosis lung fibroblasts.
Ikeda, T., Fragiadaki, M., Shi-Wen, X., Ponticos, M., Khan, K., Denton, C., . . . Abraham, D. (2016). Transforming growth factor-<i>β</i>-induced CUX1 isoforms are associated with fibrosis in systemic sclerosis lung fibroblasts.. Biochemistry and biophysics reports, 7, 246-252. doi:10.1016/j.bbrep.2016.06.022
Deficiency and also transgenic overexpression of Timp-3 both lead to compromised bone mass and architecture in vivo
Javaheri, B., Hopkinson, M., Poulet, B., Pollard, A. S., Shefelbine, S. J., Chang, Y. M., . . . Pitsillides, A. A. (2016). Deficiency and also transgenic overexpression of Timp-3 both lead to compromised bone mass and architecture in vivo. PLoS ONE, 11(8). doi:10.1371/journal.pone.0159657
RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes
McDermott, B., Ellis, S., Bou-Gharios, G., Clegg, P., & Tew, S. (2016). RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes. Osteoarthritis and Cartilage, 24(7), 1263-1273. doi:10.1016/j.joca.2016.01.988
An Intronic Flk1 Enhancer Directs Arterial-Specific Expression via RBPJ-Mediated Venous Repression
Becker, P. W., Sacilotto, N., Nornes, S., Neal, A., Thomas, M. O., Liu, K., . . . De Val, S. (2016). An Intronic Flk1 Enhancer Directs Arterial-Specific Expression via RBPJ-Mediated Venous Repression. Arteriosclerosis, Thrombosis and Vascular Biology, 36(6), 1209-1219. doi:10.1161/ATVBAHA.116.307517
Loss of the longevity gene SirT1 dysregulates chondrocytes and leads to an arthritic phenotype in vivo, via impaired autophagy
Sacitharan, P. K., Zarebska, J., Gharios, G. B., Vincent, T., & Edwards, J. (n.d.). Loss of the longevity gene SirT1 dysregulates chondrocytes and leads to an arthritic phenotype in vivo, via impaired autophagy. Bone Abstracts. doi:10.1530/boneabs.5.oc6.6
A CLUSTER OF REGULATORY ELEMENTS THAT DRIVES THE AGGRECAN GENE EXPRESSION IN CHONDROCYTES
Li, I. M., Liu, K., Neal, A., Clegg, P. D., De Val, S., & Bou-Gharios, G. (2016). A CLUSTER OF REGULATORY ELEMENTS THAT DRIVES THE AGGRECAN GENE EXPRESSION IN CHONDROCYTES. In OSTEOARTHRITIS AND CARTILAGE Vol. 24 (pp. S136-S137). doi:10.1016/j.joca.2016.01.268
CONNECTIVE TISSUE GROWTH FACTOR DEFICIENCY IN ADULT ARTICULAR CARTILAGE PROMOTES CARTILAGE DEGENERATION AT EARLY TIMEPOINTSIN MOUSE POSTTRAUMATIC OSTEOARTHRITIS
Poulet, B., Milner, P., Kanakis, I., Carter, A., Abraham, D., Leask, A., . . . Bou-Gharios, G. (2016). CONNECTIVE TISSUE GROWTH FACTOR DEFICIENCY IN ADULT ARTICULAR CARTILAGE PROMOTES CARTILAGE DEGENERATION AT EARLY TIMEPOINTSIN MOUSE POSTTRAUMATIC OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 24 (pp. S392). doi:10.1016/j.joca.2016.01.705
THE ROLE OF MICRORNAS IN OSTEOARTHRITIS AND AGEING RELATED FUNCTIONAL DECLINE IN JOINT TISSUE HOMEOSTASIS.
House, L., Bou-Gharios, G., Peffers, M., Milner, P., Clegg, P. D., Young, D. A., & Whysall, K. A. (2016). THE ROLE OF MICRORNAS IN OSTEOARTHRITIS AND AGEING RELATED FUNCTIONAL DECLINE IN JOINT TISSUE HOMEOSTASIS.. In OSTEOARTHRITIS AND CARTILAGE Vol. 24 (pp. S63-S64). doi:10.1016/j.joca.2016.01.141
Human Chorionic Stem Cells: Podocyte Differentiation and Potential for the Treatment of Alport Syndrome
Moschidou, D., Corcelli, M., Hau, K. -L., Ekwalla, V. J., Behmoaras, J. V., De Coppi, P., . . . Guillot, P. V. (2016). Human Chorionic Stem Cells: Podocyte Differentiation and Potential for the Treatment of Alport Syndrome. STEM CELLS AND DEVELOPMENT, 25(5), 395-404. doi:10.1089/scd.2015.0305
2015
SYSTEMATIZING MURINE MENISCAL AND LIGAMENT MODIFICATIONS DURING OSTEOARTHRITIS
Poulet, B., Bou-Gharios, G., & Pitsillides, A. A. (2015). SYSTEMATIZING MURINE MENISCAL AND LIGAMENT MODIFICATIONS DURING OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 23 (pp. A283). doi:10.1016/j.joca.2015.02.516
Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis
Gardiner, M. D., Vincent, T. L., Driscoll, C., Burleigh, A., Bou-Gharios, G., Saklatvala, J., . . . Chanalaris, A. (2015). Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis. Osteoarthritis and Cartilage, 23(4), 616-628. doi:10.1016/j.joca.2014.12.014
Failed Degradation of JunB Contributes to Overproduction of Type I Collagen and Development of Dermal Fibrosis in Patients With Systemic Sclerosis
Ponticos, M., Papaioannou, I., Xu, S., Holmes, A. M., Khan, K., Denton, C. P., . . . Abraham, D. J. (2015). Failed Degradation of JunB Contributes to Overproduction of Type I Collagen and Development of Dermal Fibrosis in Patients With Systemic Sclerosis. Arthritis and Rheumatology, 67(1), 243-253. doi:10.1002/art.38897
2014
Transforming growth factor-β-independent role of connective tissue growth factor in the development of liver fibrosis.
Sakai, K., Jawaid, S., Sasaki, T., Bou-Gharios, G., & Sakai, T. (2014). Transforming growth factor-β-independent role of connective tissue growth factor in the development of liver fibrosis.. The American journal of pathology, 184(10), 2611-2617. doi:10.1016/j.ajpath.2014.06.009
Generation of a Mouse Line Harboring a Bi-Transgene Expressing Luciferase and Tamoxifen-Activatable CreER<SUP>T2</SUP> Recombinase in Cartilage
Lo Cascio, L., Liu, K., Nakamura, H., Chu, G., Lim, N. H., Chanalaris, A., . . . Bou-Gharios, G. (2014). Generation of a Mouse Line Harboring a Bi-Transgene Expressing Luciferase and Tamoxifen-Activatable CreER<SUP>T2</SUP> Recombinase in Cartilage. GENESIS, 52(2), 110-119. doi:10.1002/dvg.22734
<i>In vivo</i> imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis
Lim, N. H., Meinjohanns, E., Meldal, M., Bou-Gharios, G., & Nagase, H. (2014). <i>In vivo</i> imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis. OSTEOARTHRITIS AND CARTILAGE, 22(6), 862-868. doi:10.1016/j.joca.2014.04.006
Biphasic recruitment of microchimeric fetal mesenchymal cells in fibrosis following acute kidney injury
Roy, E., Seppanen, E., Ellis, R., Lee, E. S., Khosroterani, K., Fisk, N. M., & Bou-Gharios, G. (2014). Biphasic recruitment of microchimeric fetal mesenchymal cells in fibrosis following acute kidney injury. KIDNEY INTERNATIONAL, 85(3), 600-610. doi:10.1038/ki.2013.459
In Vivo Imaging of Matrix Metalloproteinase 12 and Matrix Metalloproteinase 13 Activities in the Mouse Model of Collagen-Induced Arthritis
Lim, N. H., Meinjohanns, E., Bou-Gharios, G., Gompels, L. L., Nuti, E., Rossello, A., . . . Nagase, H. (2014). In Vivo Imaging of Matrix Metalloproteinase 12 and Matrix Metalloproteinase 13 Activities in the Mouse Model of Collagen-Induced Arthritis. Arthritis and Rheumatology, 66(3), 589-598. doi:10.1002/art.38295
Transforming Growth Factor-β–Independent Role of Connective Tissue Growth Factor in the Development of Liver Fibrosis
Sakai, K., Jawaid, S., Sasaki, T., Bou-Gharios, G., & Sakai, T. (2014). Transforming Growth Factor-β–Independent Role of Connective Tissue Growth Factor in the Development of Liver Fibrosis. AMERICAN JOURNAL OF PATHOLOGY, 184(10), 2611-2617. doi:10.1016/j.ajpath.2014.06.009
2013
Heat shock protein B1-deficient mice display impaired wound healing.
Crowe, J., Aubareda, A., McNamee, K., Przybycien, P. M., Lu, X., Williams, R. O., . . . Dean, J. L. E. (2013). Heat shock protein B1-deficient mice display impaired wound healing.. PloS one, 8(10), e77383. doi:10.1371/journal.pone.0077383
Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease.
Lindahl, G. E., Stock, C. J., Shi-Wen, X., Leoni, P., Sestini, P., Howat, S. L., . . . Renzoni, E. A. (2013). Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease.. Respiratory research, 14, 80. doi:10.1186/1465-9921-14-80
Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development.
Sacilotto, N., Monteiro, R., Fritzsche, M., Becker, P. W., Sanchez-Del-Campo, L., Liu, K., . . . De Val, S. (2013). Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development.. Proceedings of the National Academy of Sciences of the United States of America, 110(29), 11893-11898. doi:10.1073/pnas.1300805110
Distant mesenchymal progenitors contribute to skin wound healing and produce collagen: evidence from a murine fetal microchimerism model.
Seppanen, E., Roy, E., Ellis, R., Bou-Gharios, G., Fisk, N. M., & Khosrotehrani, K. (2013). Distant mesenchymal progenitors contribute to skin wound healing and produce collagen: evidence from a murine fetal microchimerism model.. PloS one, 8(5), e62662. doi:10.1371/journal.pone.0062662
Wound-associated macrophages control collagen 1α2 transcription during the early stages of skin wound healing.
Rodero, M. P., Legrand, J. M. D., Bou-Gharios, G., & Khosrotehrani, K. (2013). Wound-associated macrophages control collagen 1α2 transcription during the early stages of skin wound healing.. Experimental dermatology, 22(2), 143-145. doi:10.1111/exd.12068
2012
Fetal microchimeric cells in a fetus-treats-its-mother paradigm do not contribute to dystrophin production in serially parous mdx females.
Seppanen, E. J., Hodgson, S. S., Khosrotehrani, K., Bou-Gharios, G., & Fisk, N. M. (2012). Fetal microchimeric cells in a fetus-treats-its-mother paradigm do not contribute to dystrophin production in serially parous mdx females.. Stem cells and development, 21(15), 2809-2816. doi:10.1089/scd.2012.0047
Ontological differences in first compared to third trimester human fetal placental chorionic stem cells.
Jones, G. N., Moschidou, D., Puga-Iglesias, T. -I., Kuleszewicz, K., Vanleene, M., Shefelbine, S. J., . . . Guillot, P. V. (2012). Ontological differences in first compared to third trimester human fetal placental chorionic stem cells.. PloS one, 7(9), e43395. doi:10.1371/journal.pone.0043395
Hyperglycemia causes renal cell damage via CCN2-induced activation of the TrkA receptor: implications for diabetic nephropathy.
Fragiadaki, M., Hill, N., Hewitt, R., Bou-Gharios, G., Cook, T., Tam, F. W., . . . Mason, R. M. (2012). Hyperglycemia causes renal cell damage via CCN2-induced activation of the TrkA receptor: implications for diabetic nephropathy.. Diabetes, 61(9), 2280-2288. doi:10.2337/db11-1138
Generation of an inducible cartilage specific deleter using human aggrecan enhancer/promoter that is trackable in vivo using luciferase
Bou-Gharios, G., Layyous, A., Liu, K., Nakamura, H., Lo Cascio, L., & Saklatvala, J. (2012). Generation of an inducible cartilage specific deleter using human aggrecan enhancer/promoter that is trackable in vivo using luciferase. Osteoarthritis and Cartilage, 20, S60. doi:10.1016/j.joca.2012.02.026
TGF-b signaling in cartilage homeostasis and osteoarthritis.
Finnson, K. W., Chi, Y., Bou-Gharios, G., Leask, A., & Philip, A. (2012). TGF-b signaling in cartilage homeostasis and osteoarthritis.. Frontiers in bioscience (Scholar edition), 4(1), 251-268. doi:10.2741/s266
2011
Interstitial fibrosis is associated with increased COL1A2 transcription in AA-injured renal tubular epithelial cells in vivo.
Fragiadaki, M., Witherden, A. S., Kaneko, T., Sonnylal, S., Pusey, C. D., Bou-Gharios, G., & Mason, R. M. (2011). Interstitial fibrosis is associated with increased COL1A2 transcription in AA-injured renal tubular epithelial cells in vivo.. Matrix biology : journal of the International Society for Matrix Biology, 30(7-8), 396-403. doi:10.1016/j.matbio.2011.07.004
High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1.
Fragiadaki, M., Ikeda, T., Witherden, A., Mason, R. M., Abraham, D., & Bou-Gharios, G. (2011). High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1.. Molecular biology of the cell, 22(11), 1836-1844. doi:10.1091/mbc.e10-08-0669
Microchimeric fetal cells are recruited to maternal kidney following injury and activate collagen type I transcription.
Bou-Gharios, G., Amin, F., Hill, P., Nakamura, H., Maxwell, P., & Fisk, N. M. (2011). Microchimeric fetal cells are recruited to maternal kidney following injury and activate collagen type I transcription.. Cells, tissues, organs, 193(6), 379-392. doi:10.1159/000321172
Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties.
Vanleene, M., Saldanha, Z., Cloyd, K. L., Jell, G., Bou-Gharios, G., Bassett, J. H. D., . . . Shefelbine, S. J. (2011). Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties.. Blood, 117(3), 1053-1060. doi:10.1182/blood-2010-05-287565
Differential contribution of dermal resident and bone marrow-derived cells to collagen production during wound healing and fibrogenesis in mice.
Higashiyama, R., Nakao, S., Shibusawa, Y., Ishikawa, O., Moro, T., Mikami, K., . . . Inagaki, Y. (2011). Differential contribution of dermal resident and bone marrow-derived cells to collagen production during wound healing and fibrogenesis in mice.. The Journal of investigative dermatology, 131(2), 529-536. doi:10.1038/jid.2010.314
2010
Fetal stem cell microchimerism: natural-born healers or killers?
Lee, E. S. M., Bou-Gharios, G., Seppanen, E., Khosrotehrani, K., & Fisk, N. M. (2010). Fetal stem cell microchimerism: natural-born healers or killers?. Molecular human reproduction, 16(11), 869-878. doi:10.1093/molehr/gaq067
Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.
Sonnylal, S., Shi-Wen, X., Leoni, P., Naff, K., Van Pelt, C. S., Nakamura, H., . . . de Crombrugghe, B. (2010). Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.. Arthritis and rheumatism, 62(5), 1523-1532. doi:10.1002/art.27382
Scleroderma and Related Disorders [202-212]: 202. Multi-Centre Audit of Treatment of Interstitial Lung Disease in Systemic Sclerosis with IV Cyclophosphamide
Yazdani, R., Abhishek, A., Fiona, P., Lim, K., Regan, M., Lanyon, P., . . . Abraham, D. (2010). Scleroderma and Related Disorders [202-212]: 202. Multi-Centre Audit of Treatment of Interstitial Lung Disease in Systemic Sclerosis with IV Cyclophosphamide. Rheumatology, 49(Supplement 1), i111-i115. doi:10.1093/rheumatology/keq726
2009
Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.
Ponticos, M., Holmes, A. M., Shi-wen, X., Leoni, P., Khan, K., Rajkumar, V. S., . . . Lindahl, G. E. (2009). Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.. Arthritis and rheumatism, 60(7), 2142-2155. doi:10.1002/art.24620
JunB mediates enhancer/promoter activity of COL1A2 following TGF-beta induction.
Ponticos, M., Harvey, C., Ikeda, T., Abraham, D., & Bou-Gharios, G. (2009). JunB mediates enhancer/promoter activity of COL1A2 following TGF-beta induction.. Nucleic acids research, 37(16), 5378-5389. doi:10.1093/nar/gkp544
Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice.
Higashiyama, R., Moro, T., Nakao, S., Mikami, K., Fukumitsu, H., Ueda, Y., . . . Inagaki, Y. (2009). Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice.. Gastroenterology, 137(4), 1459-66.e1. doi:10.1053/j.gastro.2009.07.006
2008
CDP/cux is capable of strong inhibition of the COL1A2 gene
Fragiadaki, M., Ikeda, T., Abraham, D., & Bou-Gharios, G. (2008). CDP/cux is capable of strong inhibition of the COL1A2 gene. Matrix Biology, 27, 18. doi:10.1016/j.matbio.2008.09.254
Does TIMP-3 protect articular cartilage in OA model
Nakamura, H., Vo, P., Lim, N. H., Liu, K., Nagase, H., & Bou-Gharios, G. (2008). Does TIMP-3 protect articular cartilage in OA model. Matrix Biology, 27, 27-28. doi:10.1016/j.matbio.2008.09.291
Transplantation of human fetal mesenchymal stem cells improves glomerulopathy in a collagen type I alpha 2-deficient mouse.
Guillot, P. V., Cook, H. T., Pusey, C. D., Fisk, N. M., Harten, S., Moss, J., . . . Bou-Gharios, G. (2008). Transplantation of human fetal mesenchymal stem cells improves glomerulopathy in a collagen type I alpha 2-deficient mouse.. The Journal of pathology, 214(5), 627-636. doi:10.1002/path.2325
PO.24 NO EVIDENCE OF LIVER FIBROSIS IMPROVEMENT AFTER BONE MARROW STEM CELL THERAPY IN A CCL4 MURINE MODEL OF LIVER INJURY
Russo, F. P., Amofah, E., Kallis, Y. N., Bou-Gharios, G., Nicholas A, W., Alison, M. R., & Forbes, S. J. (2008). PO.24 NO EVIDENCE OF LIVER FIBROSIS IMPROVEMENT AFTER BONE MARROW STEM CELL THERAPY IN A CCL4 MURINE MODEL OF LIVER INJURY. Digestive and Liver Disease, 40, S179. doi:10.1016/s1590-8658(08)60478-8
Bone marrow-derived myofibroblasts contribute functionally to scar formation after myocardial infarction.
van Amerongen, M. J., Bou-Gharios, G., Popa, E., van Ark, J., Petersen, A. H., van Dam, G. M., . . . Harmsen, M. C. (2008). Bone marrow-derived myofibroblasts contribute functionally to scar formation after myocardial infarction.. The Journal of pathology, 214(3), 377-386. doi:10.1002/path.2281
Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice.
Guillot, P. V., Abass, O., Bassett, J. H. D., Shefelbine, S. J., Bou-Gharios, G., Chan, J., . . . Fisk, N. M. (2008). Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice.. Blood, 111(3), 1717-1725. doi:10.1182/blood-2007-08-105809
Type I Collagen Structure, Synthesis, and Regulation
Bou-Gharios, G., & de Crombrugghe, B. (2008). Type I Collagen Structure, Synthesis, and Regulation. In PRINCIPLES OF BONE BIOLOGY, VOL 1, 3RD EDITION (pp. 285-318). doi:10.1016/B978-0-12-373884-4.00034-3
2007
Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.
Shi-wen, X., Kennedy, L., Renzoni, E. A., Bou-Gharios, G., du Bois, R. M., Black, C. M., . . . Leask, A. (2007). Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.. Arthritis and rheumatism, 56(12), 4189-4194. doi:10.1002/art.23134
Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts.
Shi-Wen, X., Renzoni, E. A., Kennedy, L., Howat, S., Chen, Y., Pearson, J. D., . . . Leask, A. (2007). Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts.. Matrix biology : journal of the International Society for Matrix Biology, 26(8), 625-632. doi:10.1016/j.matbio.2007.06.003
Implication of the satellite cell in dystrophic muscle fibrosis: a self-perpetuating mechanism of collagen overproduction.
Alexakis, C., Partridge, T., & Bou-Gharios, G. (2007). Implication of the satellite cell in dystrophic muscle fibrosis: a self-perpetuating mechanism of collagen overproduction.. American journal of physiology. Cell physiology, 293(2), C661-C669. doi:10.1152/ajpcell.00061.2007
2006
Bone marrow stem cells contribution to tissue fibrosis
BOUGHARIOS, G. (2006). Bone marrow stem cells contribution to tissue fibrosis. Matrix Biology, 25, S23-S24. doi:10.1016/j.matbio.2006.08.066
CTGF overexpressing mice: a model for human scleroderma
SONNYLAL, S., BOUGHARIOS, G., ABRAHAM, D., & DECROMBRUGGHE, B. (2006). CTGF overexpressing mice: a model for human scleroderma. Matrix Biology, 25, S32-S33. doi:10.1016/j.matbio.2006.08.091
Transcriptional regulation of the human alpha2(I) collagen gene
ANTONIV, T., TANAKA, S., RAMIREZ, F., & BOUGHARIOS, G. (2006). Transcriptional regulation of the human alpha2(I) collagen gene. Matrix Biology, 25, S78. doi:10.1016/j.matbio.2006.08.215
The role of the homeobox transcription factor NKX2.5 in the regulation of collagen in vessels and in the atherosclerotic lesion
Ponticos, M., Jackson, C., Bou-Gharios, G., & Abraham, D. (2006). The role of the homeobox transcription factor NKX2.5 in the regulation of collagen in vessels and in the atherosclerotic lesion. Vascular Pharmacology, 45(3), e45-e46. doi:10.1016/j.vph.2006.08.158
Transcriptional regulation of the human alpha2(I) collagen gene (COL1A2), an informative model system to study fibrotic diseases.
Ramirez, F., Tanaka, S., & Bou-Gharios, G. (2006). Transcriptional regulation of the human alpha2(I) collagen gene (COL1A2), an informative model system to study fibrotic diseases.. Matrix biology : journal of the International Society for Matrix Biology, 25(6), 365-372. doi:10.1016/j.matbio.2006.05.002
Hammerhead ribozyme-mediated silencing of the mutant fibrillin-1 of tight skin mouse: insight into the functional role of mutant fibrillin-1.
Menon, R. P., Menon, M. R., Shi-Wen, X., Renzoni, E., Bou-Gharios, G., Black, C. M., & Abraham, D. J. (2006). Hammerhead ribozyme-mediated silencing of the mutant fibrillin-1 of tight skin mouse: insight into the functional role of mutant fibrillin-1.. Experimental cell research, 312(9), 1463-1474. doi:10.1016/j.yexcr.2006.01.011
CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.
Shi-wen, X., Stanton, L. A., Kennedy, L., Pala, D., Chen, Y., Howat, S. L., . . . Leask, A. (2006). CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.. The Journal of biological chemistry, 281(16), 10715-10726. doi:10.1074/jbc.m511343200
338 Failure of bone marrow stem cell therapy to improve liver fibrosis in the cci4 murine model
Russo, F. P., Amofah, E., Goldin, R., Vig, P., Bou-Gharios, G., Hansho, R., . . . Forbes, S. J. (2006). 338 Failure of bone marrow stem cell therapy to improve liver fibrosis in the cci4 murine model. Journal of Hepatology, 44, S130. doi:10.1016/s0168-8278(06)80339-9
Organ-specific collagen expression: implications for renal disease.
Alexakis, C., Maxwell, P., & Bou-Gharios, G. (2006). Organ-specific collagen expression: implications for renal disease.. Nephron. Experimental nephrology, 102(3-4), e71-e75. doi:10.1159/000089684
Bone marrow-derived cells do not contribute significantly to collagen I synthesis in a murine model of renal fibrosis.
Roufosse, C., Bou-Gharios, G., Prodromidi, E., Alexakis, C., Jeffery, R., Khan, S., . . . Cook, H. T. (2006). Bone marrow-derived cells do not contribute significantly to collagen I synthesis in a murine model of renal fibrosis.. Journal of the American Society of Nephrology : JASN, 17(3), 775-782. doi:10.1681/asn.2005080795
Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing.
Rajkumar, V. S., Shiwen, X., Bostrom, M., Leoni, P., Muddle, J., Ivarsson, M., . . . Abraham, D. J. (2006). Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing.. The American journal of pathology, 169(6), 2254-2265. doi:10.2353/ajpath.2006.060196
The bone marrow functionally contributes to liver fibrosis.
Russo, F. P., Alison, M. R., Bigger, B. W., Amofah, E., Florou, A., Amin, F., . . . Forbes, S. J. (2006). The bone marrow functionally contributes to liver fibrosis.. Gastroenterology, 130(6), 1807-1821. doi:10.1053/j.gastro.2006.01.036
2005
Identification of a repressor in the first intron of the human alpha2(I) collagen gene (COL1A2).
Antoniv, T. T., Tanaka, S., Sudan, B., De Val, S., Liu, K., Wang, L., . . . Ramirez, F. (2005). Identification of a repressor in the first intron of the human alpha2(I) collagen gene (COL1A2).. The Journal of biological chemistry, 280(42), 35417-35423. doi:10.1074/jbc.m502681200
Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k).
Denton, C. P., Lindahl, G. E., Khan, K., Shiwen, X., Ong, V. H., Gaspar, N. J., . . . Black, C. M. (2005). Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k).. The Journal of biological chemistry, 280(16), 16053-16065. doi:10.1074/jbc.m413134200
Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles.
Lu, Q. L., Rabinowitz, A., Chen, Y. C., Yokota, T., Yin, H., Alter, J., . . . Partridge, T. (2005). Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles.. Proceedings of the National Academy of Sciences of the United States of America, 102(1), 198-203. doi:10.1073/pnas.0406700102
Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice.
Inagaki, Y., Kushida, M., Higashi, K., Itoh, J., Higashiyama, R., Hong, Y. Y., . . . Ikeda, K. (2005). Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice.. Gastroenterology, 129(1), 259-268. doi:10.1053/j.gastro.2005.03.088
Effects of T-lymphocyte depletion on muscle fibrosis in the mdx mouse.
Morrison, J., Palmer, D. B., Cobbold, S., Partridge, T., & Bou-Gharios, G. (2005). Effects of T-lymphocyte depletion on muscle fibrosis in the mdx mouse.. The American journal of pathology, 166(6), 1701-1710. doi:10.1016/s0002-9440(10)62480-7
Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.
Chen, Y., Shi-Wen, X., van Beek, J., Kennedy, L., McLeod, M., Renzoni, E. A., . . . Leask, A. (2005). Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.. The American journal of pathology, 167(6), 1699-1711. doi:10.1016/s0002-9440(10)61252-7
Nude mutation influences limb skeletal muscle development.
Morrison, J., Partridge, T., & Bou-Gharios, G. (2005). Nude mutation influences limb skeletal muscle development.. Matrix biology : journal of the International Society for Matrix Biology, 23(8), 535-542. doi:10.1016/j.matbio.2004.10.003
2004
Cooperativity between far upstream enhancer and proximal promoter elements of the human {alpha}2(I) collagen (COL1A2) gene instructs tissue specificity in transgenic mice.
Tanaka, S., Antoniv, T. T., Liu, K., Wang, L., Wells, D. J., Ramirez, F., & Bou-Gharios, G. (2004). Cooperativity between far upstream enhancer and proximal promoter elements of the human {alpha}2(I) collagen (COL1A2) gene instructs tissue specificity in transgenic mice.. The Journal of biological chemistry, 279(53), 56024-56031. doi:10.1074/jbc.m411406200
Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts.
Renzoni, E. A., Abraham, D. J., Howat, S., Shi-Wen, X., Sestini, P., Bou-Gharios, G., . . . du Bois, R. M. (2004). Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts.. Respiratory research, 5, 24. doi:10.1186/1465-9921-5-24
Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and deltaEF1/ZEB1.
Ponticos, M., Partridge, T., Black, C. M., Abraham, D. J., & Bou-Gharios, G. (2004). Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and deltaEF1/ZEB1.. Molecular and cellular biology, 24(14), 6151-6161. doi:10.1128/mcb.24.14.6151-6161.2004
Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.
Shi-Wen, X., Chen, Y., Denton, C. P., Eastwood, M., Renzoni, E. A., Bou-Gharios, G., . . . Abraham, D. J. (2004). Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.. Molecular biology of the cell, 15(6), 2707-2719. doi:10.1091/mbc.e03-12-0902
Extra-cellular matrix in vascular networks.
Bou-Gharios, G., Ponticos, M., Rajkumar, V., & Abraham, D. (2004). Extra-cellular matrix in vascular networks.. Cell proliferation, 37(3), 207-220. doi:10.1111/j.1365-2184.2004.00306.x
Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.
Xu, S. -W., Howat, S. L., Renzoni, E. A., Holmes, A., Pearson, J. D., Dashwood, M. R., . . . Abraham, D. J. (2004). Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.. The Journal of biological chemistry, 279(22), 23098-23103. doi:10.1074/jbc.m311430200
Transplantation of skeletal myoblasts secreting an IL-1 inhibitor modulates adverse remodeling in infarcted murine myocardium.
Murtuza, B., Suzuki, K., Bou-Gharios, G., Beauchamp, J. R., Smolenski, R. T., Partridge, T. A., & Yacoub, M. H. (2004). Transplantation of skeletal myoblasts secreting an IL-1 inhibitor modulates adverse remodeling in infarcted murine myocardium.. Proceedings of the National Academy of Sciences of the United States of America, 101(12), 4216-4221. doi:10.1073/pnas.0306205101
Col1a2 enhancer regulates collagen activity during development and in adult tissue repair.
Ponticos, M., Abraham, D., Alexakis, C., Lu, Q. -L., Black, C., Partridge, T., & Bou-Gharios, G. (2004). Col1a2 enhancer regulates collagen activity during development and in adult tissue repair.. Matrix biology : journal of the International Society for Matrix Biology, 22(8), 619-628. doi:10.1016/j.matbio.2003.12.002
2003
Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse.
Lu, Q. L., Mann, C. J., Lou, F., Bou-Gharios, G., Morris, G. E., Xue, S. -A., . . . Wilton, S. D. (2003). Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse.. Nature medicine, 9(8), 1009-1014. doi:10.1038/nm897
Non-viral gene delivery in skeletal muscle: a protein factory.
Lu, Q. L., Bou-Gharios, G., & Partridge, T. A. (2003). Non-viral gene delivery in skeletal muscle: a protein factory.. Gene therapy, 10(2), 131-142. doi:10.1038/sj.gt.3301874
2002
Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat model.
Vernet, D., Ferrini, M. G., Valente, E. G., Magee, T. R., Bou-Gharios, G., Rajfer, J., & Gonzalez-Cadavid, N. F. (2002). Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat model.. Nitric oxide : biology and chemistry, 7(4), 262-276. doi:10.1016/s1089-8603(02)00124-6
Identification of the key regions within the mouse pro-alpha 2(I) collagen gene far-upstream enhancer.
De Val, S., Ponticos, M., Antoniv, T. T., Wells, D. J., Abraham, D., Partridge, T., & Bou-Gharios, G. (2002). Identification of the key regions within the mouse pro-alpha 2(I) collagen gene far-upstream enhancer.. The Journal of biological chemistry, 277(11), 9286-9292. doi:10.1074/jbc.m111040200
2001
Characterization of an evolutionarily conserved far-upstream enhancer in the human alpha 2(I) collagen (COL1A2) gene.
Antoniv, T. T., De Val, S., Wells, D., Denton, C. P., Rabe, C., de Crombrugghe, B., . . . Bou-Gharios, G. (2001). Characterization of an evolutionarily conserved far-upstream enhancer in the human alpha 2(I) collagen (COL1A2) gene.. The Journal of biological chemistry, 276(24), 21754-21764. doi:10.1074/jbc.m101397200
Activation of a fibroblast-specific enhancer of the proalpha2(I) collagen gene in tight-skin mice.
Denton, C. P., Zheng, B., Shiwen, X., Zhang, Z., Bou-Gharios, G., Eberspaecher, H., . . . de Crombrugghe, B. (2001). Activation of a fibroblast-specific enhancer of the proalpha2(I) collagen gene in tight-skin mice.. Arthritis and rheumatism, 44(3), 712-722. doi:3.0.co;2-1">10.1002/1529-0131(200103)44:3<712::aid-anr121>3.0.co;2-1
Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1.
Shi-Wen, X., Denton, C. P., Dashwood, M. R., Holmes, A. M., Bou-Gharios, G., Pearson, J. D., . . . Abraham, D. J. (2001). Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1.. The Journal of investigative dermatology, 116(3), 417-425. doi:10.1046/j.1523-1747.2001.01256.x
2000
T-cell-dependent fibrosis in the mdx dystrophic mouse.
Morrison, J., Lu, Q. L., Pastoret, C., Partridge, T., & Bou-Gharios, G. (2000). T-cell-dependent fibrosis in the mdx dystrophic mouse.. Laboratory investigation; a journal of technical methods and pathology, 80(6), 881-891. doi:10.1038/labinvest.3780092
1999
Potentiation of myoblast transplantation by host muscle irradiation is dependent on the rate of radiation delivery.
Gross, J. G., Bou-Gharios, G., & Morgan, J. E. (1999). Potentiation of myoblast transplantation by host muscle irradiation is dependent on the rate of radiation delivery.. Cell and tissue research, 298(2), 371-375. doi:10.1007/s004419900062
Differential expression and secretion of alpha 1 anti-trypsin between direct DNA injection and implantation of transfected myoblast.
Bou-Gharios, G., Wells, D. J., Lu, Q. L., Morgan, J. E., & Partridge, T. (1999). Differential expression and secretion of alpha 1 anti-trypsin between direct DNA injection and implantation of transfected myoblast.. Gene therapy, 6(6), 1021-1029. doi:10.1038/sj.gt.3300933
1998
Activation of Proalpha2(I) collagen promoter during hepatic fibrogenesis in transgenic mice.
Inagaki, Y., Truter, S., Bou-Gharios, G., Garrett, L. A., de Crombrugghe, B., Nemoto, T., & Greenwel, P. (1998). Activation of Proalpha2(I) collagen promoter during hepatic fibrogenesis in transgenic mice.. Biochemical and biophysical research communications, 250(3), 606-611. doi:10.1006/bbrc.1998.9345
1997
Scleroderma lung fibroblasts exhibit elevated and dysregulated type I collagen biosynthesis
Shi-Wen, X., Denton, C. P., McWhirter, A., Bou-Gharios, G., Abraham, D. J., du Bois, R. M., & Black, C. M. (1997). Scleroderma lung fibroblasts exhibit elevated and dysregulated type I collagen biosynthesis. Arthritis Rheum, 40(7), 1237-1244. doi:10.1002/1529-0131(199707)40:7<1237::AID-ART7>3.0.CO;2-Y
Scleroderma lung fibroblasts exhibit elevated and dysregulated type I collagen biosynthesis.
Shi-Wen, X., Denton, C. P., McWhirter, A., Bou-Gharios, G., Abraham, D. J., du Bois, R. M., & Black, C. M. (1997). Scleroderma lung fibroblasts exhibit elevated and dysregulated type I collagen biosynthesis.. Arthritis and rheumatism, 40(7), 1237-1244. doi:3.0.co;2-y">10.1002/1529-0131(199707)40:7<1237::aid-art7>3.0.co;2-y
1996
A potent far-upstream enhancer in the mouse pro alpha 2(I) collagen gene regulates expression of reporter genes in transgenic mice.
Bou-Gharios, G., Garrett, L. A., Rossert, J., Niederreither, K., Eberspaecher, H., Smith, C., . . . Crombrugghe, B. (1996). A potent far-upstream enhancer in the mouse pro alpha 2(I) collagen gene regulates expression of reporter genes in transgenic mice.. The Journal of cell biology, 134(5), 1333-1344. doi:10.1083/jcb.134.5.1333
1995
Expression of ectopeptidases in scleroderma.
Bou-Gharios, G., Osman, J., Atherton, A., Monoghan, P., Vancheeswaran, R., Black, C., & Olsen, I. (1995). Expression of ectopeptidases in scleroderma.. Annals of the rheumatic diseases, 54(2), 111-116. doi:10.1136/ard.54.2.111
Scleroderma-derived human fibroblasts retain abnormal phenotypic and functional characteristics following retroviral transduction with the SV40 tsT antigen.
Xu, S., Vancheeswaran, R., Bou-Gharios, G., O'Hare, M. J., Olsen, I., Abraham, D., & Black, C. (1995). Scleroderma-derived human fibroblasts retain abnormal phenotypic and functional characteristics following retroviral transduction with the SV40 tsT antigen.. Experimental cell research, 220(2), 407-414. doi:10.1006/excr.1995.1332
1994
Excess matrix accumulation in scleroderma is caused partly by differential regulation of stromelysin and TIMP-1 synthesis.
Bou-Gharios, G., Osman, J., Black, C., & Olsen, I. (1994). Excess matrix accumulation in scleroderma is caused partly by differential regulation of stromelysin and TIMP-1 synthesis.. Clinica chimica acta; international journal of clinical chemistry, 231(1), 69-78. doi:10.1016/0009-8981(94)90255-0
Regulation of CD2-mediated heterotypic interactions of murine T lymphocytes.
Abraham, D., Bou-Gharios, G., Tulip, G., Sumner, H., & Olsen, I. (1994). Regulation of CD2-mediated heterotypic interactions of murine T lymphocytes.. Cellular immunology, 156(2), 342-356. doi:10.1006/cimm.1994.1180
1993
Lysosomal storage diseases: mechanisms of enzyme replacement therapy.
Bou-Gharios, G., Abraham, D., & Olsen, I. (1993). Lysosomal storage diseases: mechanisms of enzyme replacement therapy.. The Histochemical journal, 25(9), 593-605. doi:10.1007/bf00157873
Correction of a lysosomal deficiency by contact-mediated enzyme transfer after bone marrow transplantation.
Bou-Gharios, G., Adams, G., Pace, P., Warden, P., & Olsen, I. (1993). Correction of a lysosomal deficiency by contact-mediated enzyme transfer after bone marrow transplantation.. Transplantation, 56(4), 991-996. doi:10.1097/00007890-199310000-00040
Lysosomal enzyme transfer from different types of lymphoid cell.
Olsen, I., Bou-Gharios, G., Abraham, D., & Chain, B. (1993). Lysosomal enzyme transfer from different types of lymphoid cell.. Experimental cell research, 209(1), 133-139. doi:10.1006/excr.1993.1293
1992
Long-term effects of bone marrow transplantation on lysosomal enzyme replacement in beta-glucuronidase-deficient mice.
Bou-Gharios, G., Adams, G., Pace, P., & Olsen, I. (1992). Long-term effects of bone marrow transplantation on lysosomal enzyme replacement in beta-glucuronidase-deficient mice.. Journal of inherited metabolic disease, 15(6), 899-910. doi:10.1007/bf01800230
Expression and function of heterotypic adhesion molecules during differentiation of human skeletal muscle in culture.
Beauchamp, J. R., Abraham, D. J., Bou-Gharios, G., Partridge, T. A., & Olsen, I. (1992). Expression and function of heterotypic adhesion molecules during differentiation of human skeletal muscle in culture.. The American journal of pathology, 140(2), 387-401.
1991
Contact-dependent transfer of a lysosomal enzyme from lymphocytes to fibroblasts.
Bou-Gharios, G., Moss, J., Partridge, T., Abraham, D., & Olsen, I. (1991). Contact-dependent transfer of a lysosomal enzyme from lymphocytes to fibroblasts.. Journal of cell science, 100 ( Pt 3), 443-449. doi:10.1242/jcs.100.3.443
Localization of lysosomal antigens in activated T-lymphocytes.
Bou-Gharios, G., Moss, J., & Olsen, I. (1991). Localization of lysosomal antigens in activated T-lymphocytes.. The Histochemical journal, 23(10), 474-482. doi:10.1007/bf01041378
Adhesive interactions between lymphocytes and skeletal muscle cells in tissue culture.
Beauchamp, J. R., Partridge, T., Abraham, D. J., Bou-Gharios, G., & O1sen, I. (1991). Adhesive interactions between lymphocytes and skeletal muscle cells in tissue culture.. Rheumatology (United Kingdom), 30, 137.
Function and regulation of the murine lymphocyte CD2 receptor.
Abraham, D. J., Bou-Gharios, G., Beauchamp, J. R., Plater-Zyberk, C., Maini, R. N., & Olsen, I. (1991). Function and regulation of the murine lymphocyte CD2 receptor.. Journal of leukocyte biology, 49(4), 329-341. doi:10.1002/jlb.49.4.329
Simultaneous measurement of cell surface and intracellular antigens by multiple flow cytometry.
Sumner, H., Abraham, D., Bou-Gharios, G., Plater-Zyberk, C., & Olsen, I. (1991). Simultaneous measurement of cell surface and intracellular antigens by multiple flow cytometry.. Journal of immunological methods, 136(2), 259-267. doi:10.1016/0022-1759(91)90012-5
1990
Interactions between lymphocytes and dermal fibroblasts: an in vitro model of cutaneous lymphocyte trafficking.
Abraham, D., Bokth, S., Bou-Gharios, G., Beauchamp, J., & Olsen, I. (1990). Interactions between lymphocytes and dermal fibroblasts: an in vitro model of cutaneous lymphocyte trafficking.. Experimental cell research, 190(1), 118-126. doi:10.1016/0014-4827(90)90152-z
The activation of resting lymphocytes is accompanied by the biogenesis of lysosomal organelles.
Olsen, I., Bou-Gharios, G., & Abraham, D. (1990). The activation of resting lymphocytes is accompanied by the biogenesis of lysosomal organelles.. European journal of immunology, 20(10), 2161-2170. doi:10.1002/eji.1830201003
1989
Adhesion of lymphoid cells to fibroblasts in tissue culture.
Abraham, D., Bou-Gharios, G., Muir, H., & Olsen, I. (1989). Adhesion of lymphoid cells to fibroblasts in tissue culture.. Cellular immunology, 122(1), 33-47. doi:10.1016/0008-8749(89)90146-9
Endopeptidase activities associated with the plasma membrane compartment of an antigen-presenting B cell.
Chain, B. M., Bou-Gharios, G., & Olsen, I. (1989). Endopeptidase activities associated with the plasma membrane compartment of an antigen-presenting B cell.. Clinical and experimental immunology, 75(1), 87-92.
1988
Cell contact induces the synthesis of a lysosomal enzyme precursor in lymphocytes and its direct transfer to fibroblasts.
Olsen, I., Abraham, D., Shelton, I., Bou-Gharios, G., Muir, H., & Winchester, B. (1988). Cell contact induces the synthesis of a lysosomal enzyme precursor in lymphocytes and its direct transfer to fibroblasts.. Biochimica et biophysica acta, 968(3), 312-322. doi:10.1016/0167-4889(88)90022-5
A simple technique for in situ embedding of monolayer cultures in Lowicryl K4M
Bou-Gharios, G., Adams, G., Moss, J., Shore, I., & Olsen, I. (1988). A simple technique for in situ embedding of monolayer cultures in Lowicryl K4M. J Microsc, 150(Pt 2), 161-163. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/3411605
A simple technique for in situ embedding of monolayer cultures in Lowicryl K4M.
Bou-Gharios, G., Adams, G., Moss, J., Shore, I., & Olsen, I. (1988). A simple technique for in situ embedding of monolayer cultures in Lowicryl K4M.. Journal of microscopy, 150(Pt 2), 161-163. doi:10.1111/j.1365-2818.1988.tb04606.x
Forms and intracellular distribution of alpha-D-mannosidases in murine liver and spleen.
Abraham, D., Bou-Gharios, G., Olsen, I., Shelton, I., Smith, R., & Winchester, B. (1988). Forms and intracellular distribution of alpha-D-mannosidases in murine liver and spleen.. The International journal of biochemistry, 20(4), 439-447. doi:10.1016/0020-711x(88)90213-3
Ultrastructural localization of a lysosomal enzyme in resin-embedded lymphocytes.
Bou-Gharios, G., Moss, J., Olsen, I., & Partridge, T. (1988). Ultrastructural localization of a lysosomal enzyme in resin-embedded lymphocytes.. Histochemistry, 89(1), 69-74. doi:10.1007/bf00496587
Ultrastructural studies of a lysosomal enzyme during lymphocyte activation.
Bou-Gharios, G., Moss, J., Abraham, D., Partridge, T., & Olsen, I. (1988). Ultrastructural studies of a lysosomal enzyme during lymphocyte activation.. British journal of experimental pathology, 69(5), 661-670.
1986
Effects of mitogenic stimulation on lymphocyte alpha-D-mannosidases.
Abraham, D., Bou-Gharios, G., Muir, H., Olsen, I., Smith, R., & Winchester, B. (1986). Effects of mitogenic stimulation on lymphocyte alpha-D-mannosidases.. European journal of cell biology, 40(2), 167-175.