Publications
2024
Symmetrical Phosphinic Acids: Synthesis and Esterification Optimization toward Potential HIV Prodrugs.
Hayat, K., Nixon, G., Zhang, Q., & Matziari, M. (2024). Symmetrical Phosphinic Acids: Synthesis and Esterification Optimization toward Potential HIV Prodrugs.. ACS omega, 9(40), 41742-41757. doi:10.1021/acsomega.4c05988
Introduction to 'Medicinal Chemistry Small Molecule Probes'.
Nixon, G., Rahman, K. M., & Spencer, J. (2024). Introduction to 'Medicinal Chemistry Small Molecule Probes'.. RSC chemical biology, 5(5), 395-396. doi:10.1039/d4cb90005g
Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in <i>Plasmodium falciparum</i>.
Lisauskaitė, M., Nixon, G. L., Woodley, C. M., Berry, N. G., Coninckx, A., Qie, L. C., . . . O'Neill, P. M. (2024). Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in <i>Plasmodium falciparum</i>.. RSC chemical biology, 5(1), 19-29. doi:10.1039/d3cb00109a
2023
Targeted Destruction of S100A4 Inhibits Metastasis of Triple Negative Breast Cancer Cells
Ismail, T. M., Crick, R. G., Du, M., Shivkumar, U., Carnell, A., Barraclough, R., . . . Rudland, P. S. (2023). Targeted Destruction of S100A4 Inhibits Metastasis of Triple Negative Breast Cancer Cells. BIOMOLECULES, 13(7). doi:10.3390/biom13071099
Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis
Jeffreys, L. N., Ardrey, A., Hafiz, T. A., Dyer, L. -A., Warman, A. J., Mosallam, N., . . . Biagini, G. A. (2023). Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis. ACS INFECTIOUS DISEASES. doi:10.1021/acsinfecdis.2c00283
2021
Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis
McGillan, P., Berry, N. G., Nixon, G. L., Leung, S. C., Webborn, P. J. H., Wenlock, M. C., . . . O’Neill, P. M. (2021). Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis. ACS Medicinal Chemistry Letters, 12(9), 1421-1426. doi:10.1021/acsmedchemlett.1c00216
Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205
Woodley, C. M., Nixon, G. L., Basilico, N., Parapini, S., Hong, W. D., Ward, S. A., . . . O'Neill, P. M. (2021). Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205. ACS MEDICINAL CHEMISTRY LETTERS, 12(7), 1077-1085. doi:10.1021/acsmedchemlett.1c00031
Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2?
Stachulski, A. V., Taujanskas, J., Pate, S. L., Rajoli, R. K. R., Aljayyoussi, G., Pennington, S. H., . . . O'Neill, P. M. (2021). Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2?. ACS INFECTIOUS DISEASES, 7(6), 1317-1331. doi:10.1021/acsinfecdis.0c00478
2019
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis
Hong, W. D., Benayoud, F., Nixon, G. L., Ford, L., Johnston, K. L., Clare, R. H., . . . O'Neill, P. M. (2019). AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(4), 1414-1419. doi:10.1073/pnas.1816585116
Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides
Clare, R. H., Bardelle, C., Harper, P., Hong, W. D., Borjesson, U., Johnston, K. L., . . . Ward, S. A. (2019). Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides. NATURE COMMUNICATIONS, 10. doi:10.1038/s41467-018-07826-2
2018
Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties
David Hong, W., Leung, S. C., Amporndanai, K., Davies, J., Priestley, R. S., Nixon, G. L., . . . O'Neill, P. M. (2018). Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties. ACS Medicinal Chemistry Letters, 9(12), 1205-1210. doi:10.1021/acsmedchemlett.8b00371
Proteolysis-targeting chimera (PROTAC) compounds to degrade S100A4 and inhibit breast cancer metastasis
Du, M., Wang, G., Ismail, T. M., Crick, R., Barraclough, R., Daimark, B. H., . . . Rudland, P. (2018). Proteolysis-targeting chimera (PROTAC) compounds to degrade S100A4 and inhibit breast cancer metastasis. In ANNALS OF ONCOLOGY Vol. 29. Retrieved from https://www.webofscience.com/
Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria
O' Neill, P. M., Stocks, P. A., Sabbani, S., Roberts, N. L., Amewu, R. K., Shore, E. R., . . . Ward, S. A. (2018). Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria. BIOORGANIC & MEDICINAL CHEMISTRY, 26(11), 2996-3005. doi:10.1016/j.bmc.2018.05.006
Repurposing and Reformulation of the Antiparasitic Agent Flubendazole for Treatment of Cryptococcal Meningoencephalitis, a Neglected Fungal Disease
Nixon, G. L., McEntee, L., Johnson, A., Farrington, N., Whalley, S., Livermore, J., . . . Hope, W. (2018). Repurposing and Reformulation of the Antiparasitic Agent Flubendazole for Treatment of Cryptococcal Meningoencephalitis, a Neglected Fungal Disease. Antimicrobial Agents and Chemotherapy, 62(4), e01909-e01917. doi:10.1128/aac.01909-17
2017
Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library
Johnston, K. L., Cook, D. A. N., Berry, N. G., Hong, W. D., Clare, R. H., Goddard, M., . . . Taylor, M. J. (2017). Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library. SCIENCE ADVANCES, 3(09). doi:10.1126/sciadv.aao1551
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
O'Neill, P. M., Amewu, R. K., Charman, S. A., Sabbani, S., Gnädig, N. F., Straimer, J., . . . Ward, S. A. (2017). A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance. Nature Communications, 8. doi:10.1038/ncomms15159
Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis.
Hong, W. D., Gibbons, P. D., Leung, S. C., Amewu, R., Stocks, P. A., Stachulski, A. V., . . . Nixon, G. L. (2017). Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis.. Journal of medicinal chemistry, 60(9), 3703-3726. doi:10.1021/acs.jmedchem.6b01718
2016
Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action
Fernandez-Alvaro, E., Hong, W. D., Nixon, G. L., O'Neil, P. M., & Calderon, F. (2016). Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action. JOURNAL OF MEDICINAL CHEMISTRY, 59(12), 5587-5603. doi:10.1021/acs.jmedchem.5b01485
Tripodal Tris-N-oxides: Synthesis and Hydrogen Bonding Capabilities
Nixon, G., Billington, H., Kalindjian, S., Steiner, A., & O'Neil, I. (2016). Tripodal Tris-N-oxides: Synthesis and Hydrogen Bonding Capabilities. Synlett, 27(01), 141-145. doi:10.1055/s-0035-1560533
Optimisation of the synthesis of second generation 1,2,4,5 tetraoxane antimalarials
O' Neill, P. M., Sabbani, S., Nixon, G. L., Schnaderbeck, M., Roberts, N. L., Shore, E. R., . . . Amewu, R. K. (2016). Optimisation of the synthesis of second generation 1,2,4,5 tetraoxane antimalarials. TETRAHEDRON, 72(40), 6118-6126. doi:10.1016/j.tet.2016.08.043
2015
Carbamoyl triazoles, Known Serine Protease Inhibitors, are a potent New Class of Antimalarial
O'Neill, P., McConville, M., Fernandez-molina, J., Angulo-Barturen, I., Bahamontes, N. R., Ballell-Pages, L., . . . Calderon, F. (2015). Carbamoyl triazoles, Known Serine Protease Inhibitors, are a potent New Class of Antimalarial. Journal of Medicinal Chemistry, 58(16), 6448-6455. doi:10.1021/acs.jmedchem.5b00434
2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties
Charoensutthivarakul, S., Hong, W. D., Leung, S. C., Gibbons, P. D., Bedingfield, P. T. P., Nixon, G. L., . . . O'Neill, P. M. (2015). 2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties. MEDCHEMCOMM, 6(7), 1252-1259. doi:10.1039/c5md00062a
Inhibitors of the Plasmodium Mitochondrial Respiratory Chain
Nixon, G. L., Ward, S. A., O’Neill, P. M., & Biagini, G. A. (2014). Inhibitors of the Plasmodium Mitochondrial Respiratory Chain. In Encyclopedia of Malaria (pp. 1-18). Springer New York. doi:10.1007/978-1-4614-8757-9_15-1
2013
Targeting the mitochondrial electron transport chain of <i>Plasmodium falciparum</i>: new strategies towards the development of improved antimalarials for the elimination era
Nixon, G. L., Pidathala, C., Shone, A. E., Antoine, T., Fisher, N., O'Neill, P. M., . . . Biagini, G. A. (2013). Targeting the mitochondrial electron transport chain of <i>Plasmodium falciparum</i>: new strategies towards the development of improved antimalarials for the elimination era. FUTURE MEDICINAL CHEMISTRY, 5(13), 1573-1591. doi:10.4155/fmc.13.180
Antimalarial pharmacology and therapeutics of atovaquone
Nixon, G. L., Moss, D. M., Shone, A. E., Lalloo, D. G., Fisher, N., O'Neill, P. M., . . . Biagini, G. A. (2013). Antimalarial pharmacology and therapeutics of atovaquone. Journal of Antimicrobial Chemotherapy, 68(5), 977-985. doi:10.1093/jac/dks504
Antimalarial pharmacology and therapeutics of atovaquone
Nixon, G. L., Moss, D. M., Shone, A. E., Lalloo, D. G., Fisher, N., O'Neill, P. M., . . . Biagini, G. A. (2013). Antimalarial pharmacology and therapeutics of atovaquone. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 68(5), 977-985. doi:10.1093/jac/dks504
2012
Generation of quinolone antimalarials targeting the <i>Plasmodium falciparum</i> mitochondrial respiratory chain for the treatment and prophylaxis of malaria
Biagini, G. A., Fisher, N., Shone, A. E., Mubaraki, M. A., Srivastava, A., Hill, A., . . . Ward, S. A. (2012). Generation of quinolone antimalarials targeting the <i>Plasmodium falciparum</i> mitochondrial respiratory chain for the treatment and prophylaxis of malaria. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(21), 8298-8303. doi:10.1073/pnas.1205651109
Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods
Sharma, R., Lawrenson, A. S., Fisher, N. E., Warman, A. J., Shone, A. E., Hill, A., . . . Berry, N. G. (2012). Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods. JOURNAL OF MEDICINAL CHEMISTRY, 55(7), 3144-3154. doi:10.1021/jm3001482
Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2)
Pidathala, C., Amewu, R., Pacorel, B., Nixon, G. L., Gibbons, P., Hong, W. D., . . . O'Neill, P. M. (2012). Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2). JOURNAL OF MEDICINAL CHEMISTRY, 55(5), 1831-1843. doi:10.1021/jm201179h
Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2)
Leung, S. C., Gibbons, P., Amewu, R., Nixon, G. L., Pidathala, C., Hong, W. D., . . . O'Neill, P. M. (2012). Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2). JOURNAL OF MEDICINAL CHEMISTRY, 55(5), 1844-1857. doi:10.1021/jm201184h
2010
Endoperoxide Carbonyl Falcipain 2/3 Inhibitor Hybrids: Toward Combination Chemotherapy of Malaria through a Single Chemical Entity
Gibbons, P., Verissimo, E., Araujo, N. C., Barton, V., Nixon, G. L., Amewu, R. K., . . . O'Neill, P. M. (2010). Endoperoxide Carbonyl Falcipain 2/3 Inhibitor Hybrids: Toward Combination Chemotherapy of Malaria through a Single Chemical Entity. JOURNAL OF MEDICINAL CHEMISTRY, 53(22), 8202-8206. doi:10.1021/jm1009567
Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins
O'Neill, P. M., Amewu, R. K., Nixon, G. L., ElGarah, F. B., Mungthin, M., Chadwick, J., . . . Ward, S. A. (2010). Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 49(33), 5693-5697. doi:10.1002/anie.201001026
Identification of a 1,2,4,5‐Tetraoxane Antimalarial Drug‐Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins
O'Neill, P. M., Amewu, R. K., Nixon, G. L., Bousejra ElGarah, F., Mungthin, M., Chadwick, J., . . . Ward, S. A. (2010). Identification of a 1,2,4,5‐Tetraoxane Antimalarial Drug‐Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins. Angewandte Chemie, 122(33), 5829-5833. doi:10.1002/ange.201001026
A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of <i>Plasmodium falciparum</i>
Fisher, N., Hill, A., Mbekeani, A., Shone, A., Nixon, G., Stocks, P., . . . Biagini, G. A. (2010). A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of <i>Plasmodium falciparum</i>. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1797, 80. doi:10.1016/j.bbabio.2010.04.241
Synthesis, <i>in vitro</i> and <i>in vivo</i> antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared <i>via</i> thiol-olefin co-oxygenation (TOCO) of allylic alcohols
Amewu, R., Gibbons, P., Mukhtar, A., Stachulski, A. V., Ward, S. A., Hall, C., . . . O'Neill, P. M. (2010). Synthesis, <i>in vitro</i> and <i>in vivo</i> antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared <i>via</i> thiol-olefin co-oxygenation (TOCO) of allylic alcohols. ORGANIC & BIOMOLECULAR CHEMISTRY, 8(9), 2068-2077. doi:10.1039/b924319d
A novel drug for uncomplicated malaria: targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNdh2) of Plasmodium falciparum
Ward, S. A., Fisher, N., Hill, A., Mbekeani, A., Shone, A., Nixon, G., . . . Biagini, G. A. (2010). A novel drug for uncomplicated malaria: targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNdh2) of Plasmodium falciparum. Malaria journal, 9(Suppl 2), I14. doi:10.1186/1475-2875-9-s2-i14
Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH:quinone oxidoreductase
Biagini, G. A., Hill, A., Mbekeani, A., Shone, A., Nixon, G., Stocks, P., . . . Ward, S. A. (2010). Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH:quinone oxidoreductase. Malaria journal, 9(Suppl 2), O4. doi:10.1186/1475-2875-9-s2-o4
2009
Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4′-Fluoro and 4′-Chloro Analogues of Amodiaquine. Identification of a Suitable "Back-Up" Compound for <i>N-tert</i>-Butyl Isoquine
O'Neill, P. M., Shone, A. E., Stanford, D., Nixon, G., Asadollahy, E., Park, B. K., . . . Ward, S. A. (2009). Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4′-Fluoro and 4′-Chloro Analogues of Amodiaquine. Identification of a Suitable "Back-Up" Compound for <i>N-tert</i>-Butyl Isoquine. JOURNAL OF MEDICINAL CHEMISTRY, 52(7), 1828-1844. doi:10.1021/jm8012757
ChemInform Abstract: Piperidine Dispiro‐1,2,4‐trioxane Analogues.
Sabbani, S., Stocks, P. A., Ellis, G. L., Davies, J., Hedenstrom, E., Ward, S. A., & O'Neill, P. M. (2009). ChemInform Abstract: Piperidine Dispiro‐1,2,4‐trioxane Analogues.. ChemInform, 40(9). doi:10.1002/chin.200909168
2008
Piperidine dispiro-1,2,4-trioxane analogues
Sabbani, S., Stocks, P. A., Ellis, G. L., Davies, J., Hedenstrom, E., Ward, S. A., & O'Neill, P. M. (2008). Piperidine dispiro-1,2,4-trioxane analogues. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(21), 5804-5808. doi:10.1016/j.bmcl.2008.09.052
ChemInform Abstract: An Efficient Route into Synthetically Challenging Bridged Achiral 1,2,4,5‐Tetraoxanes with Antimalarial Activity.
Ellis, G. L., Amewu, R., Hall, C., Rimmer, K., Ward, S. A., & O'Neill, P. M. (2008). ChemInform Abstract: An Efficient Route into Synthetically Challenging Bridged Achiral 1,2,4,5‐Tetraoxanes with Antimalarial Activity.. ChemInform, 39(37). doi:10.1002/chin.200837161
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles
Ellis, G. L., Amewu, R., Sabbani, S., Stocks, P. A., Shone, A., Stanford, D., . . . O'Neill, P. M. (2008). Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles. JOURNAL OF MEDICINAL CHEMISTRY, 51(7), 2170-2177. doi:10.1021/jm701435h
An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity
Ellis, G. L., Amewu, R., Hall, C., Rimmer, K., Ward, S. A., & O’Neill, P. M. (2008). An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity. Bioorganic & Medicinal Chemistry Letters, 18(5), 1720-1724. doi:10.1016/j.bmcl.2008.01.053
An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity
Ellis, G. L., Amewu, R., Hall, C., Rimmer, K., Ward, S. A., & O'Neill, P. M. (2008). An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(5), 1720-1724. doi:10.1016/j.bmcl.2008.01.053
2007
Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs
Stocks, P. A., Bray, P. G., Barton, V. E., Al‐Helal, M., Jones, M., Araujo, N. C., . . . O'Neill, P. M. (2007). Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs. Angewandte Chemie, 119(33), 6394-6399. doi:10.1002/ange.200604697
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs
Stocks, P. A., Bray, P. G., Barton, V. E., Al-Helal, M., Jones, M., Araujo, N. C., . . . O'Neill, P. M. (2007). Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 46(33), 6278-6283. doi:10.1002/anie.200604697
The diastereoselective synthesis of functionalised spirocyclic lactams and lactones using a Cope elimination/intramolecular nitrone cycloaddition strategy
Ellis, G. L., O'Neil, I. A., Ramos, V. E., Kalindjian, S. B., Chorlton, A. P., & Tapolczay, D. J. (2007). The diastereoselective synthesis of functionalised spirocyclic lactams and lactones using a Cope elimination/intramolecular nitrone cycloaddition strategy. TETRAHEDRON LETTERS, 48(10), 1687-1690. doi:10.1016/j.tetlet.2007.01.046
The synthesis of functionalised chiral bicyclic lactam and lactone N-oxides using a tandem Cope elimination/reverse Cope elimination protocol
Ellis, G. L., O'Neil, I. A., Ramos, V. E., Cleator, E., Kalindjian, S. B., Chorlton, A. P., & Tapolczay, D. J. (2007). The synthesis of functionalised chiral bicyclic lactam and lactone N-oxides using a tandem Cope elimination/reverse Cope elimination protocol. TETRAHEDRON LETTERS, 48(10), 1683-1686. doi:10.1016/j.tetlet.2007.01.045
The diastereoselective synthesis of functionalised spirocyclic lactams and lactones using a Cope elimination/intramolecular nitrone cycloaddition strategy
Ellis, G. L., O’Neil, I. A., Ramos, V. E., Kalindjian, S. B., Chorlton, A. P., & Tapolczay, D. J. (2007). The diastereoselective synthesis of functionalised spirocyclic lactams and lactones using a Cope elimination/intramolecular nitrone cycloaddition strategy. Tetrahedron Letters, 48(10), 1687-1690. doi:10.1016/j.tetlet.2007.01.046
Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs
Stocks, P. A., Bray, P. G., Barton, V., Al-Helal, M., Jones, M., Araujo, N. C., . . . O'Neill, P. (2007). Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs. Angewandte Chemie International Edition, 46(33), 6278-6283. doi:10.1002/anie.200604697
2004
The Diastereoselective Synthesis of Functionalized Isoxazolidines Using a Cope Elimination/Intramolecular Nitrone Cycloaddition Strategy.
O'Neil, I. A., Ramos, V. E., Ellis, G. L., Cleator, E., Chorlton, A. P., Tapolczay, D. J., & Kalindjian, S. B. (2004). The Diastereoselective Synthesis of Functionalized Isoxazolidines Using a Cope Elimination/Intramolecular Nitrone Cycloaddition Strategy.. ChemInform, 35(33). doi:10.1002/chin.200433148
The diastereoselective synthesis of functionalised isoxazolidines using a Cope elimination/intramolecular nitrone cycloaddition strategy
O'Neil, I. A., Ramos, V. E., Ellis, G. L., Cleator, E., Chorlton, A. P., Tapolczay, D. J., & Kalindjian, S. B. (2004). The diastereoselective synthesis of functionalised isoxazolidines using a Cope elimination/intramolecular nitrone cycloaddition strategy. Tetrahedron Letters, 45(18), 3659-3661. doi:10.1016/j.tetlet.2004.03.041