Publications
2024
Can self-testing be enhanced to hasten safe return of healthcare workers in pandemics? Random order, open label trial using two manufacturers' SARS-CoV-2 lateral flow devices concurrently and nested viral culture study.
Zhang, X., Cheyne, C. P., Jones, C., Humann, M., Leeming, G., Smith, C., . . . Buchan, I. E. (2024). Can self-testing be enhanced to hasten safe return of healthcare workers in pandemics? Random order, open label trial using two manufacturers' SARS-CoV-2 lateral flow devices concurrently and nested viral culture study.. BMC infectious diseases, 24(1), 1276. doi:10.1186/s12879-024-10155-z
A qualitative exploration of barriers to efficient and effective structured medication reviews in primary care: Findings from the DynAIRx study.
Abuzour, A. S., Wilson, S. A., Woodall, A. A., Mair, F. S., Clegg, A., Shantsila, E., . . . Walker, L. E. (2024). A qualitative exploration of barriers to efficient and effective structured medication reviews in primary care: Findings from the DynAIRx study.. PloS one, 19(8), e0299770. doi:10.1371/journal.pone.0299770
Changes in hospital mortality in patients with cancer during the COVID-19 pandemic (ISARIC-CCP-UK): a prospective, multicentre cohort study.
Turtle, L., Elliot, S., Drake, T. M., Thorpe, M., Khoury, E. G., Greenhalf, W., . . . ISARIC4C Investigators. (2024). Changes in hospital mortality in patients with cancer during the COVID-19 pandemic (ISARIC-CCP-UK): a prospective, multicentre cohort study.. The Lancet. Oncology, 25(5), 636-648. doi:10.1016/s1470-2045(24)00107-4
Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study.
Cho, S. -M., Premraj, L., Battaglini, D., Fanning, J. P., Suen, J., Bassi, G. L., . . . ISARIC Clinical Characterization Group. (2024). Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study.. Brain communications, 6(2), fcae036. doi:10.1093/braincomms/fcae036
COVID-19 risk-mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region
Burnside, G., Cheyne, C. P., Leeming, G., Humann, M., Darby, A., Green, M. A., . . . Buchan, I. E. (2024). COVID-19 risk-mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region. Journal of the Royal Society of Medicine. doi:10.1177/01410768231182389
Improving Pre-trained Language Model Sensitivity via Mask Specific losses: A case study on Biomedical NER
Abaho, M., Bollegala, D., Leeming, G., Joyce, D., & Buchan, I. (2024). Improving Pre-trained Language Model Sensitivity via Mask Specific losses: A case study on Biomedical NER. In Proceedings of the 2024 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies (Volume 1: Long Papers) (pp. 5013-5029). Association for Computational Linguistics. doi:10.18653/v1/2024.naacl-long.280
2023
A multi-country analysis of COVID-19 hospitalizations by vaccination status.
Gonçalves, B. P., Jassat, W., Baruch, J., Hashmi, M., Rojek, A., Dasgupta, A., . . . ISARIC Clinical Characterisation Group. (2023). A multi-country analysis of COVID-19 hospitalizations by vaccination status.. Med (New York, N.Y.), 4(11), 797-812.e2. doi:10.1016/j.medj.2023.08.005
How might dynamic artificial intelligence (DynAIRx) be used to support prescribing to ensure efficient medication reviews?
Abuzour, A., Wilson, S., Woodall, A., Mair, F., Bollegala, D., Cant, H., . . . Walker, L. (2023). How might dynamic artificial intelligence (DynAIRx) be used to support prescribing to ensure efficient medication reviews?. American Academy of Family Physicians. doi:10.1370/afm.22.s1.4823
International Pediatric COVID-19 Severity Over the Course of the Pandemic
Zhu, Y., Almeida, F. J., Baillie, J. K., Bowen, A. C., Britton, P. N., Brizuela, M. E., . . . Short, K. R. (2023). International Pediatric COVID-19 Severity Over the Course of the Pandemic. JAMA PEDIATRICS. doi:10.1001/jamapediatrics.2023.3117
Liver injury in hospitalized patients with COVID-19: An International observational cohort study.
Tirupakuzhi Vijayaraghavan, B. K., Bishnu, S., Baruch, J., Citarella, B. W., Kartsonaki, C., Meeyai, A., . . . ISARIC Clinical Characterisation Group. (2023). Liver injury in hospitalized patients with COVID-19: An International observational cohort study.. PloS one, 18(9), e0277859. doi:10.1371/journal.pone.0277859
Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera.
Roper, K. J., Thomas, J., Albalawi, W., Maddocks, E., Dobson, S., Alshehri, A., . . . Pollakis, G. (2023). Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera.. Scientific reports, 13(1), 15014. doi:10.1038/s41598-023-41928-2
Patient emergency health-care use before hospital admission for COVID-19 and long-term outcomes in Scotland: a national cohort study.
Docherty, A. B., Farrell, J., Thorpe, M., Egan, C., Dunn, S., Norman, L., . . . Lone, N. I. (2023). Patient emergency health-care use before hospital admission for COVID-19 and long-term outcomes in Scotland: a national cohort study.. The Lancet. Digital health, 5(7), e446-e457. doi:10.1016/s2589-7500(23)00051-1
Examining public views on decentralised health data sharing
Neumann, V., Davidge, G., Harding, M., Cunningham, J., Davies, N., Devaney, S., . . . Ainsworth, J. (2023). Examining public views on decentralised health data sharing. PLOS ONE, 18(3). doi:10.1371/journal.pone.0282257
Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study.
Turtle, L., Thorpe, M., Drake, T. M., Swets, M., Palmieri, C., Russell, C. D., . . . Docherty, A. B. (2023). Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study.. PLoS medicine, 20(1), e1004086. doi:10.1371/journal.pmed.1004086
2022
A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study
Jefferson, E., Cole, C., Mumtaz, S., Cox, S., Giles, T. C., Adejumo, S., . . . Quinlan, P. (2022). A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study. JOURNAL OF MEDICAL INTERNET RESEARCH, 24(12). doi:10.2196/40035
Changing patterns of SARS-CoV-2 infection through Delta and Omicron waves by vaccination status, previous infection and neighbourhood deprivation: a cohort analysis of 2.7 M people
Green, M. A., Hungerford, D. J., Hughes, D. M., Garcia-Finana, M., Turtle, L., Cheyne, C., . . . Buchan, I. (2022). Changing patterns of SARS-CoV-2 infection through Delta and Omicron waves by vaccination status, previous infection and neighbourhood deprivation: a cohort analysis of 2.7 M people. BMC INFECTIOUS DISEASES, 22(1). doi:10.1186/s12879-022-07878-2
Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study
Vink, E., Davis, C., MacLean, A., Pascall, D., McDonald, S. E., Gunson, R., . . . Ho, A. (2022). Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. OPEN FORUM INFECTIOUS DISEASES, 9(11). doi:10.1093/ofid/ofac531
Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number
Keeling, M. J., Dyson, L., Guyver-Fletcher, G., Holmes, A., Semple, M. G., Tildesley, M. J., & Hill, E. M. (2022). Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number. STATISTICAL METHODS IN MEDICAL RESEARCH, 31(9), 1716-1737. doi:10.1177/09622802211070257
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19
Garcia-Gallo, E., Merson, L., Kennon, K., Kelly, S., Citarella, B. W., Fryer, D. V., . . . Reyes, L. F. (2022). ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19. SCIENTIFIC DATA, 9(1). doi:10.1038/s41597-022-01534-9
CO-CONNECT: A hybrid architecture to facilitate rapid discovery and access to UK wide data in the response to the COVID-19 pandemic (Preprint)
Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study
Millar, J. E., Neyton, L., Seth, S., Dunning, J., Merson, L., Murthy, S., . . . Baillie, J. K. (2022). Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-08032-3
Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study
Narhi, F., Moonesinghe, S. R., Shenkin, S. D., Drake, T. M., Mulholland, R. H., Donegan, C., . . . Docherty, A. B. (2022). Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. LANCET DIGITAL HEALTH, 4(4). Retrieved from https://www.webofscience.com/
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (2022). SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. Cell, 185(3), 467-484.e15. doi:10.1016/j.cell.2021.12.046
The DynAIRx Project Protocol: Artificial Intelligence for dynamic prescribing optimisation and care integration in multimorbidity.
Walker, L. E., Abuzour, A. S., Bollegala, D., Clegg, A., Gabbay, M., Griffiths, A., . . . Buchan, I. (2022). The DynAIRx Project Protocol: Artificial Intelligence for dynamic prescribing optimisation and care integration in multimorbidity.. Journal of multimorbidity and comorbidity, 12, 26335565221145493. doi:10.1177/26335565221145493
2021
Mapping the human genetic architecture of COVID-19
Niemi, M. E. K., Karjalainen, J., Daly, M., Ganna, A., Mehtonen, J., Cordioli, M., . . . Dopazo, X. (2021). Mapping the human genetic architecture of COVID-19. NATURE, 600(7889), 472-+. doi:10.1038/s41586-021-03767-x
The value of open-source clinical science in pandemic response: lessons from ISARIC
The value of open-source clinical science in pandemic response: lessons from ISARIC (2021). LANCET INFECTIOUS DISEASES, 21(12), 1623-1624. doi:10.1016/S1473-3099(21)00565-X
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells
de, S. T. I., Liu, G., Lindsey, B. B., Dong, D., Moore, S. C., Hsu, N. S., . . . Dong, T. (2021). The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. ISCIENCE, 24(11). doi:10.1016/j.isci.2021.103353
Towards nationally curated data archives for clinical radiology image analysis at scale: Learnings from national data collection in response to a pandemic
Cushnan, D., Berka, R., Bertolli, O., Williams, P., Schofield, D., Joshi, I., . . . Collaborative, N. C. C. I. D. (2021). Towards nationally curated data archives for clinical radiology image analysis at scale: Learnings from national data collection in response to a pandemic. DIGITAL HEALTH, 7. doi:10.1177/20552076211048654
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
Abdukahil, S. A., Abe, R., Abel, L., Absil, L., Acker, A., Adachi, S., . . . Zucman, D. (2021). COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study. INFECTION, 49(5), 889-905. doi:10.1007/s15010-021-01599-5
Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study
Russell, C. D., Fairfield, C. J., Drake, T. M., Turtle, L., Seaton, R. A., Wootton, D. G., . . . Ho, A. (2021). Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. LANCET MICROBE, 2(8), E354-E365. doi:10.1016/S2666-5247(21)00090-2
Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study
Drake, T. M., Riad, A. M., Fairfield, C. J., Egan, C., Knight, S. R., Pius, R., . . . Semple, M. G. (2021). Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. LANCET, 398(10296), 223-237. Retrieved from https://www.webofscience.com/
Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK
Docherty, A., Mulholland, R., Lone, N. I., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . Semple, M. (2021). Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 773-785. doi:10.1016/S2213-2600(21)00175-2
Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.
Drake, T. M., Fairfield, C. J., Pius, R., Knight, S. R., Norman, L., Girvan, M., . . . ISARIC4C Investigators. (2021). Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.. The Lancet. Rheumatology, 3(7), e498-e506. doi:10.1016/s2665-9913(21)00104-1
Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort
Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., . . . Khunti, K. (2021). Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort. OBESITY, 29(7), 1223-1230. doi:10.1002/oby.23178
Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK
Bloom, C. I., Drake, T. M., Docherty, A. B., Lipworth, B. J., Johnston, S. L., Nguyen-Van-Tam, J. S., . . . Openshaw, P. J. M. (2021). Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 699-711. doi:10.1016/S2213-2600(21)00013-8
Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England
Leclerc, Q. J., Fuller, N. M., Keogh, R. H., Diaz-Ordaz, K., Sekula, R., Semple, M. G., . . . Knight, G. M. (2021). Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England. BMC HEALTH SERVICES RESEARCH, 21(1). doi:10.1186/s12913-021-06509-x
Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study
Gupta, R. K., Harrison, E. M., Ho, A., Docherty, A. B., Knight, S. R., van Smeden, M., . . . Noursadeghi, M. (2021). Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(4), 349-359. doi:10.1016/S2213-2600(20)30559-2
Genetic mechanisms of critical illness in COVID-19
Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A. D., Rawlik, K., Pasko, D., . . . Baillie, J. K. (2021). Genetic mechanisms of critical illness in COVID-19. NATURE, 591(7848), 92-+. doi:10.1038/s41586-020-03065-y
Blockchain Native Data Linkage
Cunningham, J., Davidge, G., Davies, N., Devaney, S., Holm, S., Harding, M., . . . Ainsworth, J. (2021). Blockchain Native Data Linkage. FRONTIERS IN BLOCKCHAIN, 4. doi:10.3389/fbloc.2021.667388
2020
The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity
Thomson, E., Rosen, L., Shepherd, J., Spreafico, R., da Silva Filipe, A., Wojcechowskyj, J., . . . Snell, G. (2020). The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity. doi:10.1101/2020.11.04.355842
Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020
Thompson, C. P., Grayson, N. E., Paton, R. S., Bolton, J. S., Lourenco, J., Penman, B. S., . . . Simmonds, P. (2020). Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. EUROSURVEILLANCE, 25(42), 33-41. doi:10.2807/1560-7917.ES.2020.25.42.2000685
Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.
Drake, T. M., Docherty, A. B., Harrison, E. M., Quint, J. K., Adamali, H., Agnew, S., . . . ISARIC4C Investigators. (2020). Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.. Am J Respir Crit Care Med. doi:10.1164/rccm.202007-2794OC
Designing a Solution to Manage Electronic Consent for Children
Leeming, G., Thew, S., & Ainsworth, J. (2020). Designing a Solution to Manage Electronic Consent for Children. In DIGITAL PERSONALIZED HEALTH AND MEDICINE Vol. 270 (pp. 1103-1107). doi:10.3233/SHTI200333
2019
A Ledger of Me: Personalizing Healthcare Using Blockchain Technology
Leeming, G., Cunningham, J., & Ainsworth, J. (2019). A Ledger of Me: Personalizing Healthcare Using Blockchain Technology. FRONTIERS IN MEDICINE, 6. doi:10.3389/fmed.2019.00171
Blockchain in health care: hype, trust, and digital health
Leeming, G., Ainsworth, J., & Clifton, D. A. (2019). Blockchain in health care: hype, trust, and digital health. LANCET, 393(10190), 2476-2477. doi:10.1016/S0140-6736(19)30948-1
2018
Addressing the Socio-Technical Challenges of Health Information Exchange Adoption: DataWell in Greater Manchester
Thew, S., Leeming, G., & Ainsworth, J. (2018). Addressing the Socio-Technical Challenges of Health Information Exchange Adoption: DataWell in Greater Manchester. In BUILDING CONTINENTS OF KNOWLEDGE IN OCEANS OF DATA: THE FUTURE OF CO-CREATED EHEALTH Vol. 247 (pp. 790-794). doi:10.3233/978-1-61499-852-5-790
2017
Computable Information Governance Contracts
Cunningham, J., Leeming, G., & Ainsworth, J. (2017). Computable Information Governance Contracts. INFORMATICS FOR HEALTH: CONNECTED CITIZEN-LED WELLNESS AND POPULATION HEALTH, 235, 476-480. doi:10.3233/978-1-61499-753-5-476
DataWell: Public Involvement in the Development of a Federated Platform for Shared Patient Records in Greater Manchester, UK
Leeming, G., & Thew, S. (2017). DataWell: Public Involvement in the Development of a Federated Platform for Shared Patient Records in Greater Manchester, UK. In PRACTICE OF PATIENT CENTERED CARE: EMPOWERING AND ENGAGING PATIENTS IN THE DIGITAL ERA Vol. 244 (pp. 48-52). doi:10.3233/978-1-61499-824-2-48