Publications
Selected publications
- The clinical and microbiological utility of inhaled aztreonam lysine for the treatment of acute pulmonary exacerbations of cystic fibrosis: An open-label randomised crossover study (AZTEC-CF) (Journal article - 2021)
- The utility of established prognostic scores in COVID-19 hospital admissions: a multi-centre prospective evaluation of CURB-65, NEWS2, and qSOFA (Journal article - 2020)
- Ivacaftor Is Associated with Reduced Lung Infection by Key Cystic Fibrosis Pathogens A Cohort Study Using National Registry Data (Journal article - 2019)
- A direct comparison of decision rules for early discharge of suspected acute coronary syndromes in the era of high sensitivity troponin. (Journal article - 2019)
- Prevalence, risk factors and outcomes of cardiac disease in cystic fibrosis: A multinational retrospective cohort study. (Journal article - 2023)
2024
Regulatory adverse drug reaction analyses support a temporal increase in psychiatric reactions after initiation of cystic fibrosis combination modulator therapies.
O'Connor, J., Nazareth, D., Wat, D., Southern, K. W., & Frost, F. (2024). Regulatory adverse drug reaction analyses support a temporal increase in psychiatric reactions after initiation of cystic fibrosis combination modulator therapies.. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, S1569-1993(24)01780-6. doi:10.1016/j.jcf.2024.09.010
Low-dose azithromycin prophylaxis in patients with atrial fibrillation and chronic obstructive pulmonary disease.
Bucci, T., Wat, D., Sibley, S., Wootton, D., Green, D., Pignatelli, P., . . . Frost, F. (2024). Low-dose azithromycin prophylaxis in patients with atrial fibrillation and chronic obstructive pulmonary disease.. Internal and emergency medicine. doi:10.1007/s11739-024-03653-0
Risk of Cardiovascular Events after Acute Exacerbations of Chronic Obstructive Pulmonary Disease in Patients Receiving Long-Term Low-Dose Azithromycin.
Bucci, T., Wat, D., Nazareth, D., Sibley, S., Wootton, D., Lip, G. Y. H., & Frost, F. (2024). Risk of Cardiovascular Events after Acute Exacerbations of Chronic Obstructive Pulmonary Disease in Patients Receiving Long-Term Low-Dose Azithromycin.. American journal of respiratory and critical care medicine, 209(11), 1394-1396. doi:10.1164/rccm.202309-1699le
Risk of Death and Cardiovascular Events in Asian Patients With Atrial Fibrillation and Chronic Obstructive Pulmonary Disease: A Report From the Prospective APHRS Registry.
Bucci, T., Romiti, G. F., Shantsila, A., Teo, W. -S., Park, H. -W., Shimizu, W., . . . Asia‐Pacific Heart Rhythm Society Atrial Fibrillation Registry Investigators. (2024). Risk of Death and Cardiovascular Events in Asian Patients With Atrial Fibrillation and Chronic Obstructive Pulmonary Disease: A Report From the Prospective APHRS Registry.. Journal of the American Heart Association, 13(7), e032785. doi:10.1161/jaha.123.032785
Cardiorespiratory Multimorbidity in People Living With Chronic Lung Disease: Challenges, Opportunities, and a Concept for Optimization via an Integrated Care Approach.
Frost, F., & Lip, G. Y. H. (2024). Cardiorespiratory Multimorbidity in People Living With Chronic Lung Disease: Challenges, Opportunities, and a Concept for Optimization via an Integrated Care Approach.. Chest, 165(3), 500-502. doi:10.1016/j.chest.2023.11.009
Impact of chronic obstructive pulmonary disease in patients with atrial fibrillation: an analysis from the GLORIA-AF registry.
Romiti, G. F., Corica, B., Mei, D. A., Frost, F., Bisson, A., Boriani, G., . . . Lip, G. Y. H. (2024). Impact of chronic obstructive pulmonary disease in patients with atrial fibrillation: an analysis from the GLORIA-AF registry.. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 26(1), euae021. doi:10.1093/europace/euae021
Impact of prior oral anticoagulation therapies on post-discharge outcomes after COVID-19: Results from a global federated health network analysis.
Rivera-Caravaca, J. M., Frost, F., Marín, F., & Lip, G. Y. H. (2024). Impact of prior oral anticoagulation therapies on post-discharge outcomes after COVID-19: Results from a global federated health network analysis.. European journal of clinical investigation, e14299. doi:10.1111/eci.14299
2023
48 Describing the epidemiological characteristics and treatment patterns of non-tuberculosis mycobacteria (NTM) infections in adults in Liverpool 2010–2022
Todd, H., Haigh, K., Frost, F., Green, D., Aston, S., Howard, A., . . . Davies, G. (2023). 48 Describing the epidemiological characteristics and treatment patterns of non-tuberculosis mycobacteria (NTM) infections in adults in Liverpool 2010–2022. Clinical Infection in Practice, 20, 100307. doi:10.1016/j.clinpr.2023.100307
Prevalence, risk factors and outcomes of cardiac disease in cystic fibrosis: A multinational retrospective cohort study.
Frost, F., Nazareth, D., Fauchier, L., Wat, D., Shelley, J., Austin, P., . . . Lip, G. Y. H. (2023). Prevalence, risk factors and outcomes of cardiac disease in cystic fibrosis: A multinational retrospective cohort study.. The European respiratory journal, 2300174. doi:10.1183/13993003.00174-2023
HEART Score Recalibration Using Higher Sensitivity Troponin T.
Khand, A. U., Backus, B., Campbell, M., Frost, F., Mullen, L., Fisher, M., . . . Mumma, B. E. (2023). HEART Score Recalibration Using Higher Sensitivity Troponin T.. Annals of emergency medicine, S0196-0644(23)00313-X. doi:10.1016/j.annemergmed.2023.04.024
2022
Challenges and opportunities in the development of novel antimicrobial therapeutics for cystic fibrosis.
Barton, T. E., Frost, F., Fothergill, J. L., & Neill, D. R. (2022). Challenges and opportunities in the development of novel antimicrobial therapeutics for cystic fibrosis.. Journal of medical microbiology, 71(12). doi:10.1099/jmm.0.001643
The long-term effects of insulin use in incident cystic fibrosis-related diabetes: a target trial emulated using longitudinal national registry data
Granger, E., Keogh, R. H., & Frost, F. (2022). The long-term effects of insulin use in incident cystic fibrosis-related diabetes: a target trial emulated using longitudinal national registry data. ERJ OPEN RESEARCH, 8(4). doi:10.1183/23120541.00170-2022
Physical activity assessment and vascular function in adults with cystic fibrosis and their non-CF peers
Shelley, J., Boddy, L., Knowles, Z., Stewart, C., Frost, F., Nazareth, D., . . . Dawson, E. (2022). Physical activity assessment and vascular function in adults with cystic fibrosis and their non-CF peers. JOURNAL OF SPORTS SCIENCES, 40(16), 1837-1848. doi:10.1080/02640414.2022.2115224
Developing an ecological approach to physical activity promotion in adults with Cystic fibrosis
Shelley, J., Dawson, E. A., Boddy, L. M., Stewart, C. E., Frost, F., Nazareth, D., . . . Knowles, Z. R. (2022). Developing an ecological approach to physical activity promotion in adults with Cystic fibrosis. PLOS ONE, 17(8). doi:10.1371/journal.pone.0272355
Dietary interventions for managing glucose abnormalities in people with cystic fibrosis
Birch, L., Perry, R., Hamilton-Shield, J., Higgins, J. P. T., Lithander, F. E., Langton Hewer, S. C., . . . Nazareth, D. (n.d.). Dietary interventions for managing glucose abnormalities in people with cystic fibrosis. Cochrane Database of Systematic Reviews, 2022(6). doi:10.1002/14651858.cd014708
2021
Antibiotic therapy for chronic infection with <I>Burkholderia cepacia</I> complex in people with cystic fibrosis
Frost, F., Shaw, M., & Nazareth, D. (2021). Antibiotic therapy for chronic infection with <I>Burkholderia cepacia</I> complex in people with cystic fibrosis. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (12). doi:10.1002/14651858.CD013079.pub3
Continuous glucose monitoring systems for monitoring cystic fibrosis-related diabetes.
Toner, A., McCloy, A., Dyce, P., Nazareth, D., & Frost, F. (2021). Continuous glucose monitoring systems for monitoring cystic fibrosis-related diabetes.. The Cochrane database of systematic reviews, 11, CD013755. doi:10.1002/14651858.cd013755.pub2
The clinical and microbiological utility of inhaled aztreonam lysine for the treatment of acute pulmonary exacerbations of cystic fibrosis: An open-label randomised crossover study (AZTEC-CF)
Frost, F., Young, G. R., Wright, L., Miah, N., Smith, D. L., Winstanley, C., . . . Nazareth, D. (2021). The clinical and microbiological utility of inhaled aztreonam lysine for the treatment of acute pulmonary exacerbations of cystic fibrosis: An open-label randomised crossover study (AZTEC-CF). JOURNAL OF CYSTIC FIBROSIS, 20(6), 994-1002. doi:10.1016/j.jcf.2020.12.012
The rapid development and deployment of a new multidisciplinary CPAP service outside of a critical care environment during the early stages of the COVID-19 pandemic.
Robinson, R. E., Nightingale, R., Frost, F., Green, T., Jones, G., Nwosu, N., . . . Gautam, M. (2021). The rapid development and deployment of a new multidisciplinary CPAP service outside of a critical care environment during the early stages of the COVID-19 pandemic.. Future healthcare journal, 8(1), e156-e159. doi:10.7861/fhj.2020-0167
THE UTILITY OF ESTABLISHED PROGNOSTIC SCORES IN COVID-19 HOSPITAL ADMISSIONS: A COLLABORATIVE TRAINEE-LED, MULTI-CENTRE PROSPECTIVE EVALUATION OF CURB-65, NEWS2, AND QSOFA
Frost, F., Bradley, P., Tharmaratnam, K., & Wootton, D. (2021). THE UTILITY OF ESTABLISHED PROGNOSTIC SCORES IN COVID-19 HOSPITAL ADMISSIONS: A COLLABORATIVE TRAINEE-LED, MULTI-CENTRE PROSPECTIVE EVALUATION OF CURB-65, NEWS2, AND QSOFA. In THORAX Vol. 76 (pp. A57-A58). doi:10.1136/thorax-2020-BTSabstracts.100
Assessing the validity and applicability of the French 3-year prognostic score in the UK cystic fibrosis population - a national cohort study
Frost, F., Nazareth, D., Shaw, M., & Al-Aloul, M. (2021). Assessing the validity and applicability of the French 3-year prognostic score in the UK cystic fibrosis population - a national cohort study. TRANSPLANT INTERNATIONAL, 34(3), 436-444. doi:10.1111/tri.13805
2020
The utility of established prognostic scores in COVID-19 hospital admissions: a multi-centre prospective evaluation of CURB-65, NEWS2, and qSOFA
Bradley, P., Frost, F., Tharmaratnam, K., & Wootton, D. G. (2020). The utility of established prognostic scores in COVID-19 hospital admissions: a multi-centre prospective evaluation of CURB-65, NEWS2, and qSOFA. BMJ Open Respiratory Research, 7(1). doi:10.1101/2020.07.15.20154815
Utility of established prognostic scores in COVID-19 hospital admissions: multicentre prospective evaluation of CURB-65, NEWS2 and qSOFA
Bradley, P., Frost, F., Tharmaratnam, K., & Wootton, D. G. (2020). Utility of established prognostic scores in COVID-19 hospital admissions: multicentre prospective evaluation of CURB-65, NEWS2 and qSOFA. BMJ OPEN RESPIRATORY RESEARCH, 7(1). doi:10.1136/bmjresp-2020-000729
Continuous glucose monitoring systems for monitoring cystic fibrosis-related diabetes
Toner, A., McCloy, A., Dyce, P., Nazareth, D., & Frost, F. (n.d.). Continuous glucose monitoring systems for monitoring cystic fibrosis-related diabetes. Cochrane Database of Systematic Reviews. doi:10.1002/14651858.cd013755
Inhaled aztreonam lysine for the treatment of acute pulmonary exacerbations of cystic fibrosis
Frost, F. (2020, September 24). Inhaled aztreonam lysine for the treatmentof acute pulmonary exacerbations of cysticfibrosis.
Cystic fibrosis-related diabetes: an update
Frost, F., Walshaw, M. J., & Nazareth, D. (2022). Cystic fibrosis-related diabetes: an update. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 115(9), 582-585. doi:10.1093/qjmed/hcaa256
Is continuous positive airway pressure (CPAP) a new standard of care for type 1 respiratory failure in COVID-19 patients? A retrospective observational study of a dedicated COVID-19 CPAP service
Nightingale, R., Nwosu, N., Kutubudin, F., Fletcher, T., Lewis, J., Frost, F., . . . Burhan, H. (2020). Is continuous positive airway pressure (CPAP) a new standard of care for type 1 respiratory failure in COVID-19 patients? A retrospective observational study of a dedicated COVID-19 CPAP service. BMJ open respiratory research, 7(1). doi:10.1136/bmjresp-2020-000639
Identification of high-risk non-ST elevation myocardial infarction at presentation to emergency department. A prospective observational cohort study in North West England.
Khand, A., Frost, F., Grainger, R., Fisher, M., Chew, P., Mullen, L., . . . Dodd, J. (2020). Identification of high-risk non-ST elevation myocardial infarction at presentation to emergency department. A prospective observational cohort study in North West England.. BMJ open, 10(6), e030128. doi:10.1136/bmjopen-2019-030128
2019
Ivacaftor Is Associated with Reduced Lung Infection by Key Cystic Fibrosis Pathogens A Cohort Study Using National Registry Data
Frost, F. J., Nazareth, D. S., Charman, S. C., Winstanley, C., & Walshaw, M. J. (2019). Ivacaftor Is Associated with Reduced Lung Infection by Key Cystic Fibrosis Pathogens A Cohort Study Using National Registry Data. ANNALS OF THE AMERICAN THORACIC SOCIETY, 16(11), 1375-1382. doi:10.1513/AnnalsATS.201902-122OC
Loss of incretin effect contributes to postprandial hyperglycaemia in cystic fibrosis-related diabetes
Frost, F., Jones, G. H., Dyce, P., Jackson, V., Nazareth, D., & Walshaw, M. J. (2019). Loss of incretin effect contributes to postprandial hyperglycaemia in cystic fibrosis-related diabetes. DIABETIC MEDICINE, 36(11), 1367-1374. doi:10.1111/dme.14121
A direct comparison of decision rules for early discharge of suspected acute coronary syndromes in the era of high sensitivity troponin.
Chew, P. G., Frost, F., Mullen, L., Fisher, M., Zadeh, H., Grainger, R., . . . Khand, A. (2019). A direct comparison of decision rules for early discharge of suspected acute coronary syndromes in the era of high sensitivity troponin. EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE, 8(5), 421-431. doi:10.1177/2048872618755369
Antibiotic therapy for chronic infection with Burkholderia cepacia complex in people with cystic fibrosis.
Frost, F., Shaw, M., & Nazareth, D. (2019). Antibiotic therapy for chronic infection with Burkholderia cepacia complex in people with cystic fibrosis.. The Cochrane database of systematic reviews, 6, CD013079. doi:10.1002/14651858.cd013079.pub2
Cystic fibrosis related diabetes is not independently associated with increased <i>Stenotrophomonas maltophilia</i> infection: Longitudinal data from updates the UK CF Registry
Frost, F., Nazareth, D., Shaw, M., & Walshaw, M. J. (2019). Cystic fibrosis related diabetes is not independently associated with increased <i>Stenotrophomonas maltophilia</i> infection: Longitudinal data from updates the UK CF Registry. JOURNAL OF CYSTIC FIBROSIS, 18(2), 294-298. doi:10.1016/j.jcf.2018.10.011
Cystic fibrosis-related diabetes: optimizing care with a multidisciplinary approach
Frost, F., Dyce, P., Ochota, A., Pandya, S., Clarke, T., Walshaw, M. J., & Nazareth, D. S. (2019). Cystic fibrosis-related diabetes: optimizing care with a multidisciplinary approach. DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, 12, 545-552. doi:10.2147/DMSO.S180597
2018
Continuous glucose monitoring guided insulin therapy is associated with improved clinical outcomes in cystic fibrosis-related diabetes
Frost, F., Dyce, P., Nazareth, D., Malone, V., & Walshaw, M. J. (2018). Continuous glucose monitoring guided insulin therapy is associated with improved clinical outcomes in cystic fibrosis-related diabetes. JOURNAL OF CYSTIC FIBROSIS, 17(6), 798-803. doi:10.1016/j.jcf.2018.05.005
Managing complications of cystic fibrosis in adults
Walshaw, M., & Frost, F. (2018). Managing complications of cystic fibrosis in adults. In Practitioner Vol. 262 (pp. 23-26).
Pulmonary function testing is safe in patients with thoracic aortic aneurysms
Frost, F., Peat, R., McWean, J., Shaw, M., Field, M., Nazareth, D., & Walshaw, M. (2018). Pulmonary function testing is safe in patients with thoracic aortic aneurysms. EUROPEAN RESPIRATORY JOURNAL, 52(5). doi:10.1183/13993003.00928-2018
BETWEEN A ROCK AND AN AIR-SPACE: PNEUMOTHORAX FOLLOWING EXTRACORPOREAL SHOCK-WAVE LITHOTRIPSY FOR RENAL STONES IN A PATIENT WITH CYSTIC FIBROSIS.
Frost, F. J., Nazareth, D., Griffiths, P., Brockelsby, C., & Walshaw, M. (n.d.). BETWEEN A ROCK AND AN AIR-SPACE: PNEUMOTHORAX FOLLOWING EXTRACORPOREAL SHOCK-WAVE LITHOTRIPSY FOR RENAL STONES IN A PATIENT WITH CYSTIC FIBROSIS.. Chest.
Case Report: First report of Elizabethkingia miricola infection in a patient with cystic fibrosis.
Frost, F., & Nazareth, D. (2018). Case Report: First report of <i>Elizabethkingia miricola</i> infection in a patient with cystic fibrosis.. F1000Research, 7, 440. doi:10.12688/f1000research.14441.2
Ghost of chest drain past
Frost, F., Hare, J., Holemans, J., & Walshaw, M. (2018). Ghost of chest drain past. THORAX, 73(6), 595-596. doi:10.1136/thoraxjnl-2017-210991
What's hot that the other lot got
Frost, F. (2018). What's hot that the other lot got. THORAX, 73(3), 302. doi:10.1136/thoraxjnl-2018-211506
Case Report: First report of Elizabethkingia miricola infection in a patient with cystic fibrosis.
Frost, F., & Nazareth, D. (2018). Case Report: First report of Elizabethkingia miricola infection in a patient with cystic fibrosis.. F1000Res, 7, 440. doi:10.12688/f1000research.14441.2
Case Report: Haemolytic anaemia with ceftazidime use in a patient with cystic fibrosis.
Yong, J., Frost, F., Nazareth, D., & Walshaw, M. (2018). Case Report: Haemolytic anaemia with ceftazidime use in a patient with cystic fibrosis.. F1000Research, 7, 475. doi:10.12688/f1000research.14505.1
2017
MODIFIED HEART SCORE IMPROVES EARLY, SAFE DISCHARGE FOR SUSPECTED ACUTE CORONARY SYNDROMES: A PROSPECTIVE COHORT STUDY WITH RECALIBRATION OF RISK SCORES TO UNDETECTABLE HIGH SENSITIVITY TROPONIN T LIMITS
Khand, A., Frost, F., Chew, P., Fisher, M., Mullen, L., Grainger, R., . . . Dodd, J. (2017). MODIFIED HEART SCORE IMPROVES EARLY, SAFE DISCHARGE FOR SUSPECTED ACUTE CORONARY SYNDROMES: A PROSPECTIVE COHORT STUDY WITH RECALIBRATION OF RISK SCORES TO UNDETECTABLE HIGH SENSITIVITY TROPONIN T LIMITS. In JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY Vol. 69 (pp. 238). doi:10.1016/S0735-1097(17)33627-6
2016
Measurement of cardiac troponin for exclusion of myocardial infarction
Mullen, L., Chew, P. G., Frost, F., Obafemi, T., & Khand, A. (2016). Measurement of cardiac troponin for exclusion of myocardial infarction. LANCET, 387(10035), 2288-2289. doi:10.1016/S0140-6736(16)30685-7
Hyperenhancement of the Pericardium on Cardiac Magnetic Resonance Imaging: A Marker of Acute Inflammation and Neovascularization or a Chronic Fibrotic State?
Mullen, L., Chew, P. G., Frost, F., Ahmed, A., & Khand, A. (2016). Hyperenhancement of the Pericardium on Cardiac Magnetic Resonance Imaging: A Marker of Acute Inflammation and Neovascularization or a Chronic Fibrotic State?. CARDIOLOGY, 133(4), 239-241. doi:10.1159/000442409