Research
Research Interest 1
My research interests are in the molecular epidemiology of healthcare-associated infections, dysbiosis following antimicrobial therapy, age-related conditions and translational medicine. My research focuses on the identification and validation of predictive biomarkers for variable response in patients in terms of diagnosis, prognosis, susceptibility and efficacy. My main research goals are in understanding the complex interplay of enteric infections and comorbidities, using genomics, transcriptomics, proteomics and metabolomics tools with a view on translational measures to control diseases, improve patient's management and treatment efficacy.
Research groups
Research grants
The Interactions Between Clostridium Difficile, Intestinal Microbiota and the Host Response in Hospitalised Patients.
MEDICAL RESEARCH COUNCIL
September 2012 - March 2018
Research collaborations
Dr. James Anson, Dr. Caroline Corless and Paul Roberts
Liverpool Clinical Laboratories - Royal Liverpool & Broadgreen Hospitals NHS Trust
Development and standardisation of methods for screening and classification of Clostridium difficile Pathological screening of specimens
Prof. Brendan Wren
London School of Hygiene and Tropical Medicine
Multicentric MRC programme grant Pathogenesis of bacterial infections
Dr. Trevor Lawley
Wellcome Trust Sanger Institute
Macro and micro evolution of epidemic bacterial strains and microbiota profiling of enteric diseases
Prof. Dyfrig Hughes
Centre for Economics, University of Bangor
Health-economics of Clostridium difficile infection
Prof. Tor Savidge
Baylor College of Medicine, Houston, Texas, USA
Metabolomics of Clostridium difficile infection Network and mechanistic analyses