Publications
2024
Galectin-3 contributes to pathogenesis of IgA nephropathy.
Chou, Y. -L., Chen, H. -L., Hsu, B. -G., Yang, C. -Y., Chen, C. -H., Lee, Y. -C., . . . Ka, S. -M. (2024). Galectin-3 contributes to pathogenesis of IgA nephropathy.. Kidney international, S0085-2538(24)00527-1. doi:10.1016/j.kint.2024.06.023
Polysaccharide sulfotransferases: the identification of putative sequences and respective functional characterisation.
Mistry, R., Byrne, D. P., Starns, D., Barsukov, I. L., Yates, E. A., & Fernig, D. G. (2024). Polysaccharide sulfotransferases: the identification of putative sequences and respective functional characterisation.. Essays in biochemistry, EBC20230094. doi:10.1042/ebc20230094
Novel sulfatase cancer therapeutics negatively impact Bacteroidota of the colonic microbiota in a non-sulfatase dependent manner
Differential Solvent DEEP-STD NMR and MD Simulations Enable the Determinants of the Molecular Recognition of Heparin Oligosaccharides by Antithrombin to Be Disentangled.
Parafioriti, M., Elli, S., Muñoz-García, J. C., Ramírez-Cárdenas, J., Yates, E. A., Angulo, J., & Guerrini, M. (2024). Differential Solvent DEEP-STD NMR and MD Simulations Enable the Determinants of the Molecular Recognition of Heparin Oligosaccharides by Antithrombin to Be Disentangled.. International journal of molecular sciences, 25(9), 4669. doi:10.3390/ijms25094669
Interactions of proteins with heparan sulfate.
Alotaibi, F. S., Alsadun, M. M. R., Alsaiari, S. A., Ramakrishnan, K., Yates, E. A., & Fernig, D. G. (2024). Interactions of proteins with heparan sulfate.. Essays in biochemistry, EBC20230093. doi:10.1042/ebc20230093
2023
Convenient syntheses of <i>trans</i>-resveratrol 3-<i>O</i> and 4′-<i>O</i>-β-<scp>d</scp>-glucuronides and a study of their aqueous stability
Fraser, M. K., Gorecka, A., Yates, E. A., Iggo, J. A., Baj, K., & Stachulski, A. V. (2023). Convenient syntheses of <i>trans</i>-resveratrol 3-<i>O</i> and 4′-<i>O</i>-β-<scp>d</scp>-glucuronides and a study of their aqueous stability. Organic Chemistry Frontiers. doi:10.1039/d3qo01736b
History and Prospects for the Sustainability and Circularity of the Windowpane Oyster Placuna placenta Fishery in the Philippines
Rustia, J. M., Antonino, J. P., Velasco, R. R., Lima, M. A., Yates, E. A., & Fernig, D. G. (2023). History and Prospects for the Sustainability and Circularity of the Windowpane Oyster Placuna placenta Fishery in the Philippines. Fishes, 8(10), 493. doi:10.3390/fishes8100493
Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects That Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells.
Pagani, I., Ottoboni, L., Panina-Bordignon, P., Martino, G., Poli, G., Taylor, S., . . . Vicenzi, E. (2023). Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects That Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells.. Pharmaceuticals (Basel, Switzerland), 16(10), 1385. doi:10.3390/ph16101385
History and Prospects for Sustainability and Circularity of the Windowpane Oyster Placuna placenta Fishery in the Philippines
Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination
Lindsay, S. L., McCanney, G. A., Zhan, J., Scheld, M., Smith, R. S., Goodyear, C. S., . . . Barnett, S. C. (2023). Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination. GLIA. doi:10.1002/glia.24363
Heparin in Acid and Alkaline Environments—A Study of the Correlations between Hydrodynamic Properties and Desulphation
Kozlowski, A. M., Dinu, V., MacCalman, T., Smith, A. M., Roubroeks, J. P., Yates, E. A., . . . Morris, G. A. (n.d.). Heparin in Acid and Alkaline Environments—A Study of the Correlations between Hydrodynamic Properties and Desulphation. Polysaccharides, 4(2), 88-98. doi:10.3390/polysaccharides4020007
Monitoring the stability of heparin: NMR evidence for the rearrangement of sulfated iduronate in phosphate buffer
Kozlowski, A. M., Yates, E. A., Roubroeks, J. P., Tommeraas, K., Larsen, F. H., Smith, A. M., & Morris, G. A. (2023). Monitoring the stability of heparin: NMR evidence for the rearrangement of sulfated iduronate in phosphate buffer. CARBOHYDRATE POLYMERS, 308. doi:10.1016/j.carbpol.2023.120649
Functions and specificity of bacterial carbohydrate sulfatases targeting host glycans
Luis, A. S., Yates, E. A., & Cartmell, A. (2023). Functions and specificity of bacterial carbohydrate sulfatases targeting host glycans. ESSAYS IN BIOCHEMISTRY, 67(3), 429-442. doi:10.1042/EBC20220120
Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State
Devlin, A. J., Mycroft-West, C. J., Turnbull, J. E., de Lima, M. A., Guerrini, M., Yates, E. A., & Skidmore, M. A. (2023). Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State. ACS CENTRAL SCIENCE, 9(3), 381-392. doi:10.1021/acscentsci.2c01176
High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts
Maciej-Hulme, M. L., Leprince, A. C. N., Lavin, A., Guimond, S. E., Turnbull, J. E., Pelletier, J., . . . Skidmore, M. A. (2023). High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts. ANALYTICAL METHODS, 15(11), 1461-1469. doi:10.1039/d2ay01803a
Validation of Recombinant Heparan Sulphate Reagents for CNS Repair
Lindsay, S. L. L., Smith, R. S., Yates, E. A. A., Cartwright, C., Thacker, B. E. E., Turnbull, J. E. E., . . . Barnett, S. C. C. (2023). Validation of Recombinant Heparan Sulphate Reagents for CNS Repair. BIOLOGY-BASEL, 12(3). doi:10.3390/biology12030407
A sulphated glycosaminoglycan extract from<i> Placopecten</i><i> magellanicus</i> inhibits the Alzheimer's disease 0-site amyloid precursor protein cleaving enzyme 1 (BACE-1)
Mycroft-West, C. J., Devlin, A. J., Cooper, L. C., Guimond, S. E., Procter, P., Miller, G. J., . . . Skidmore, M. A. (2023). A sulphated glycosaminoglycan extract from<i> Placopecten</i><i> magellanicus</i> inhibits the Alzheimer's disease 0-site amyloid precursor protein cleaving enzyme 1 (BACE-1). CARBOHYDRATE RESEARCH, 525. doi:10.1016/j.carres.2023.108747
Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors
Gray, A. L., Karlsson, R., Roberts, A. R. E., Ridley, A. J. L., Pun, N., Khan, B., . . . Dyer, D. P. (2023). Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors. CELL REPORTS, 42(1). doi:10.1016/j.celrep.2022.111930
Evidence for multiple binding modes in the initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans
Parafioriti, M., Ni, M., Petitou, M., Mycroft-West, C. J., Rudd, T. R., Gandhi, N. S., . . . Elli, S. (2023). Evidence for multiple binding modes in the initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans. CHEMISTRY-A EUROPEAN JOURNAL, 29(1). doi:10.1002/chem.202202599
2022
Heparin Protects Human Neural Progenitor Cells from Zika Virus-Induced Cell Death While Preserving Their Differentiation into Mature Neuroglial Cells
Pagani, I., Ottoboni, L., Podini, P., Ghezzi, S., Brambilla, E., Bezukladova, S., . . . Vicenzi, E. (2022). Heparin Protects Human Neural Progenitor Cells from Zika Virus-Induced Cell Death While Preserving Their Differentiation into Mature Neuroglial Cells. JOURNAL OF VIROLOGY, 96(19). doi:10.1128/jvi.01122-22
Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota (vol 18, pg 841, 2022)
Luis, A. S., Basle, A., Byrne, D. P., Wright, G. S. A., London, J. A., Jin, C., . . . Cartmell, A. (2022). Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota (vol 18, pg 841, 2022). NATURE CHEMICAL BIOLOGY, 18(9), 1032. doi:10.1038/s41589-022-01132-1
Evidence for multiple binding modes in the initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans
Phosphorylation and sulfation share a common biosynthetic pathway, but extend biochemical and evolutionary diversity of biological macromolecules in distinct ways
Lima, M. A., Rudd, T. R., Fernig, D. G., & Yates, E. A. (2022). Phosphorylation and sulfation share a common biosynthetic pathway, but extend biochemical and evolutionary diversity of biological macromolecules in distinct ways. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 19(193). doi:10.1098/rsif.2022.0391
Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota
Luis, A. S., Basle, A., Byrne, D. P., Wright, G. S. A., London, J. A., Jin, C., . . . Cartmell, A. (2022). Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota. NATURE CHEMICAL BIOLOGY, 18(8), 841-+. doi:10.1038/s41589-022-01039-x
Using NMR to Dissect the Chemical Space and O-Sulfation Effects within the <i>O</i>- and <i>S</i>-Glycoside Analogues of Heparan Sulfate
Meneghetti, M. C. Z., Naughton, L., O'Shea, C., Teki, D. S. E. K., Chagnault, V., Nader, H. B., . . . Lima, M. A. (2022). Using NMR to Dissect the Chemical Space and O-Sulfation Effects within the <i>O</i>- and <i>S</i>-Glycoside Analogues of Heparan Sulfate. ACS OMEGA. doi:10.1021/acsomega.2c02070
Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate wide-spread non-receptor mediated immune cell recruitment
Pentosan Polysulfate Inhibits Attachment and Infection by SARS-CoV-2 In Vitro: Insights into Structural Requirements for Binding
Bertini, S., Alekseeva, A., Elli, S., Pagani, I., Zanzoni, S., Eisele, G., . . . Guerrini, M. (2022). Pentosan Polysulfate Inhibits Attachment and Infection by SARS-CoV-2 In Vitro: Insights into Structural Requirements for Binding. THROMBOSIS AND HAEMOSTASIS, 122(06), 984-997. doi:10.1055/a-1807-0168
NMR spectroscopy and chemometric models to detect a specific non-porcine ruminant contaminant in pharmaceutical heparin.
Colombo, E., Mauri, L., Marinozzi, M., Rudd, T. R., Yates, E. A., Ballabio, D., & Guerrini, M. (2022). NMR spectroscopy and chemometric models to detect a specific non-porcine ruminant contaminant in pharmaceutical heparin.. Journal of pharmaceutical and biomedical analysis, 214, 114724. doi:10.1016/j.jpba.2022.114724
Initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans involves multiple binding modes
Analysis of protein-heparin interactions using a portable SPR instrument
Su, D., Li, Y., Yates, E. A., Skidmore, M. A., Lima, M. A., & Fernig, D. G. (n.d.). Analysis of protein-heparin interactions using a portable SPR instrument. PeerJ Analytical Chemistry, 4, e15. doi:10.7717/peerj-achem.15
Exploration of expanded carbohydrate chemical space to access biological activity using microwave-induced acid condensation of simple sugars
London, J. A., Taylor, S. L., Barsukov, I., Cartmell, A., & Yates, E. A. (2022). Exploration of expanded carbohydrate chemical space to access biological activity using microwave-induced acid condensation of simple sugars. RSC ADVANCES, 12(18), 11075-11083. doi:10.1039/d2ra01463g
Structural variation in the linkage region of pharmaceutical heparin arising from oxidative treatments during manufacture.
Urso, E., Mantione, G., Sala, F., Yates, E. A., Guerrini, M., & Naggi, A. (2022). Structural variation in the linkage region of pharmaceutical heparin arising from oxidative treatments during manufacture.. Carbohydrate research, 514, 108540. doi:10.1016/j.carres.2022.108540
Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction
Guimond, S. E., Mycroft-West, C. J., Gandhi, N. S., Tree, J. A., Le, T. T., Spalluto, C. M., . . . Turnbull, J. E. (2022). Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction. ACS Central Science. doi:10.1021/acscentsci.1c01293
Exploration of expanded carbohydrate chemical space to access biological activity using microwave-induced acid condensation of simple sugars
2021
Pentosan polysulfate inhibits attachment and infection by SARS-CoV-2 <i>in vitro</i>: insights into structural requirements for binding
Anion binding to a cationic europium(iii) probe enables the first real-time assay of heparan sulfotransferase activity
Wheeler, S., Breen, C., Li, Y., Hewitt, S. H., Robertson, E., Yates, E. A., . . . Butler, S. J. (2021). Anion binding to a cationic europium(iii) probe enables the first real-time assay of heparan sulfotransferase activity. ORGANIC & BIOMOLECULAR CHEMISTRY, 20(3), 596-605. doi:10.1039/d1ob02071d
Glycation of Host Proteins Increases Pathogenic Potential of <i>Porphyromonas gingivalis</i>
Smiga, M., Smalley, J. W., Slezak, P., Brown, J. L., Sieminska, K., Jenkins, R. E., . . . Olczak, T. (2021). Glycation of Host Proteins Increases Pathogenic Potential of <i>Porphyromonas gingivalis</i>. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(21). doi:10.3390/ijms222112084
A single sulfatase is required to access colonic mucin by a gut bacterium
Luis, A. S., Jin, C., Pereira, G. V., Glowacki, R. W. P., Gugel, S. R., Singh, S., . . . Martens, E. C. (2021). A single sulfatase is required to access colonic mucin by a gut bacterium. NATURE, 598(7880), 332-+. doi:10.1038/s41586-021-03967-5
Chemical Modification of Glycosaminoglycan Polysaccharides
Palhares, L. C. G. F., London, J. A., Kozlowski, A. M., Esposito, E., Chavante, S. F., Ni, M., & Yates, E. A. (2021). Chemical Modification of Glycosaminoglycan Polysaccharides. MOLECULES, 26(17). doi:10.3390/molecules26175211
Endocytosis and the Participation of Glycosaminoglycans Are Important to the Mechanism of Cell Death Induced by β-Hairpin Antimicrobial Peptides
Buri, M. V., Sperandio, L. P., de Souza, K. F. S., Antunes, F., Rezende, M. M., Melo, C. M., . . . Paredes-Gamero, E. J. (2021). Endocytosis and the Participation of Glycosaminoglycans Are Important to the Mechanism of Cell Death Induced by β-Hairpin Antimicrobial Peptides. ACS APPLIED BIO MATERIALS, 4(8), 6488-6501. doi:10.1021/acsabm.1c00390
Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota
Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota
Heparin protects human neural progenitor cells from Zika Virus-induced cell death and preserves their differentiation into mature neural-glia cells
Glycosaminoglycans from <i>Litopenaeus vannamei</i> Inhibit the Alzheimer's Disease β Secretase, BACE1
Mycroft-West, C. J., Devlin, A. J., Cooper, L. C., Guimond, S. E., Procter, P., Guerrini, M., . . . Skidmore, M. A. (2021). Glycosaminoglycans from <i>Litopenaeus vannamei</i> Inhibit the Alzheimer's Disease β Secretase, BACE1. MARINE DRUGS, 19(4). doi:10.3390/md19040203
ER-Golgi dynamics of HS-modifying enzymes via vesicular trafficking is a critical prerequisite for the delineation of HS biosynthesis
Meneghetti, M. C. Z., Deboni, P., Palomino, C. M. V., Braga, L. P., Cavalheiro, R. P., Viana, G. M., . . . Lima, M. A. (2021). ER-Golgi dynamics of HS-modifying enzymes via vesicular trafficking is a critical prerequisite for the delineation of HS biosynthesis. CARBOHYDRATE POLYMERS, 255. doi:10.1016/j.carbpol.2020.117477
Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity
Byrne, D. P., London, J. A., Eyers, P. A., Yates, E. A., & Cartmell, A. (2021). Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity. BIOCHEMICAL JOURNAL, 478(4), 735-748. doi:10.1042/BCJ20200952
Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity (vol 478, pg 735, 2021)
Byrne, D. P., London, J. A., Eyers, P. A., Yates, E. A., & Cartmell, A. (2021). Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity (vol 478, pg 735, 2021). BIOCHEMICAL JOURNAL, 478(1), 2537-2538. doi:10.1042/BCJ20200952_COR
Hydrolytic Degradation of Heparin in Acidic Environments: Nuclear Magnetic Resonance Reveals Details of Selective Desulfation
Kozlowski, A. M., Yates, E. A., Roubroeks, J. P., Tommeraas, K., Smith, A. M., & Morris, G. A. (2021). Hydrolytic Degradation of Heparin in Acidic Environments: Nuclear Magnetic Resonance Reveals Details of Selective Desulfation. ACS APPLIED MATERIALS & INTERFACES, 13(4), 5551-5563. doi:10.1021/acsami.0c20198
Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations
Tree, J. A., Turnbull, J. E., Buttigieg, K. R., Elmore, M. J., Coombes, N., Hogwood, J., . . . Carroll, M. W. (2021). Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations. BRITISH JOURNAL OF PHARMACOLOGY, 178(3), 626-635. doi:10.1111/bph.15304
A single bacterial sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium
A Review of the Distribution, Botany, Phytochemistry and Biological Activity of Dioscorine From <i>Dioscorea hispida</i>
Castillo, D. E., Fernig, D. G., Yates, E. A., & Payonga, A. P. (2021). A Review of the Distribution, Botany, Phytochemistry and Biological Activity of Dioscorine From <i>Dioscorea hispida</i>. PHILIPPINE JOURNAL OF CROP SCIENCE, 46(2). Retrieved from https://www.webofscience.com/
Synthesis and toxicity profile in 293 human embryonic kidney cells of the β D-glucuronide derivatives of <i>ortho</i>-<i>, meta</i>- and <i>para</i>-cresol
London, J. A., Wang, E. C. S., Barsukov, I. L., Yates, E. A., & Stachulski, A. V. (2021). Synthesis and toxicity profile in 293 human embryonic kidney cells of the β D-glucuronide derivatives of <i>ortho</i>-<i>, meta</i>- and <i>para</i>-cresol. CARBOHYDRATE RESEARCH, 499. doi:10.1016/j.carres.2020.108225
2020
Extracellular histones stimulate collagen expression <i>in vitro</i> and promote liver fibrogenesis in a mouse model <i>via </i>the TLR4-MyD88 signaling pathway
Wang, Z., Cheng, Z. -X., Abrams, S. T., Lin, Z. -Q., Yates, E. D., Yu, Q., . . . Wang, G. -Z. (2020). Extracellular histones stimulate collagen expression <i>in vitro</i> and promote liver fibrogenesis in a mouse model <i>via </i>the TLR4-MyD88 signaling pathway. WORLD JOURNAL OF GASTROENTEROLOGY, 26(47), 7513-7527. doi:10.3748/wjg.v26.i47.7513
Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity
Byrne, D., London, J., Eyers, P., Yates, E., & Cartmell, A. (2020). Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity. doi:10.1101/2020.12.01.406876
Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin
Mycroft-West, C. J., Su, D., Pagani, I., Rudd, T. R., Elli, S., Gandhi, N. S., . . . Skidmore, M. A. (2020). Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. THROMBOSIS AND HAEMOSTASIS, 120(12), 1700-1715. doi:10.1055/s-0040-1721319
A single bacterial sulfatase is required for metabolism of colonic mucin<i>O</i>-glycans and intestinal colonization by a symbiotic human gut bacterium
Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin
Townsend, D., Fullwood, N. J., Yates, E. A., & Middleton, D. A. (2020). Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin. BIOCHEMISTRY, 59(41), 4003-4014. doi:10.1021/acs.biochem.0c00443
Should We Be Worried About <i>Clostridioides difficile</i> During the SARS-CoV2 Pandemic?
Ferreira, E. D. O., Penna, B., & Yates, E. A. (2020). Should We Be Worried About <i>Clostridioides difficile</i> During the SARS-CoV2 Pandemic?. FRONTIERS IN MICROBIOLOGY, 11. doi:10.3389/fmicb.2020.581343
Extracellular histones stimulate collagen expression and potentially promote liver fibrogenesis via TLR4-MyD88 signalling pathway
Metabolism of multiple glycosaminoglycans by <i>Bacteroides thetaiotaomicron</i> is orchestrated by a versatile core genetic locus (vol 11, 646, 2020)
Ndeh, D., Basle, A., Strahl, H., Yates, E. A., McClurgg, U. L., Henrissat, B., . . . Cartmell, A. (2020). Metabolism of multiple glycosaminoglycans by <i>Bacteroides thetaiotaomicron</i> is orchestrated by a versatile core genetic locus (vol 11, 646, 2020). NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-18097-1
Unfractionated heparin inhibits live wild-type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations.
Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain
Mycroft-West, C., Su, D., Li, Y., Guimond, S., Rudd, T., Elli, S., . . . Skidmore, M. (2020). Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain. doi:10.1101/2020.04.29.068767
SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins
Mycroft-West, C., Su, D., Li, Y., Guimond, S., Rudd, T., Elli, S., . . . Skidmore, M. (2020). SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins. doi:10.1101/2020.04.29.068486
Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin
Mycroft-West, C., Su, D., Pagani, I., Rudd, T., Elli, S., Guimond, S., . . . Skidmore, M. (2020). Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin. doi:10.1101/2020.04.28.066761
Interaction with the heparin-derived binding inhibitors destabilizes galectin-3 protein structure
Sindrewicz, P., Yates, E. A., Turnbull, J. E., Lian, L. -Y., & Yu, L. -G. (2020). Interaction with the heparin-derived binding inhibitors destabilizes galectin-3 protein structure. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 523(2), 336-341. doi:10.1016/j.bbrc.2019.12.054
The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding
Mycroft-West, C., Su, D., Elli, S., Li, Y., Guimond, S., Miller, G., . . . Skidmore, M. (2020). The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding. doi:10.1101/2020.02.29.971093
Editorial: Heparan Sulfate Proteoglycans and Their Endogenous Modifying Enzymes: Cancer Players, Biomarkers and Therapeutic Targets
Lanzi, C., Yates, E. A., & Cassinelli, G. (2020). Editorial: Heparan Sulfate Proteoglycans and Their Endogenous Modifying Enzymes: Cancer Players, Biomarkers and Therapeutic Targets. FRONTIERS IN ONCOLOGY, 10. doi:10.3389/fonc.2020.00195
Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus
Ndeh, D., Baslé, A., Strahl, H., Yates, E. A., McClurgg, U. L., Henrissat, B., . . . Cartmell, A. (2020). Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus. Nature Communications, 11. doi:10.1038/s41467-020-14509-4
Heparan sulfate structure is influenced by the ER-Golgi dynamics of its modifying enzymes
High sensitivity (zeptomole) detection of BODIPY heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts
Maciej-Hulme, M., Leprince, A., Lavin, A., Guimond, S., Turnbull, J., Pelletier, J., . . . Skidmore, M. A. (2020). High sensitivity (zeptomole) detection of BODIPY heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts. doi:10.1101/2020.01.21.913954
SimpleDSFviewer: A tool to analyze and view differential scanning fluorimetry data for characterizing protein thermal stability and interactions
Sun, C., Li, Y., Yates, E. A., & Fernig, D. G. (2020). SimpleDSFviewer: A tool to analyze and view differential scanning fluorimetry data for characterizing protein thermal stability and interactions. PROTEIN SCIENCE, 29(1), 19-27. doi:10.1002/pro.3703
2019
A further unique chondroitin sulfate from the shrimp <i>Litopenaeus vannamei</i> with antithrombin activity that modulates acute inflammation
Palhares, L. C. G. F., Brito, A. S., de Lima, M. A., Nader, H. B., London, J. A., Barsukov, I. L., . . . Chavante, S. F. (2019). A further unique chondroitin sulfate from the shrimp <i>Litopenaeus vannamei</i> with antithrombin activity that modulates acute inflammation. CARBOHYDRATE POLYMERS, 222. doi:10.1016/j.carbpol.2019.115031
Tools for the Quality Control of Pharmaceutical Heparin
Devlin, A., Mycroft-West, C., Procter, P., Cooper, L., Guimond, S., Lima, M., . . . Skidmore, M. (2019). Tools for the Quality Control of Pharmaceutical Heparin. MEDICINA-LITHUANIA, 55(10). doi:10.3390/medicina55100636
The use of ATR-FTIR spectroscopy to characterise crude heparin samples by composition and structural features
Multivariate analysis applied to complex biological medicines
Rudd, T. R., Mauri, L., Marinozzi, M., Stancanelli, E., Yates, E. A., Naggi, A., & Guerrini, M. (2019). Multivariate analysis applied to complex biological medicines. FARADAY DISCUSSIONS, 218, 303-316. doi:10.1039/c9fd00009g
Intrinsic tryptophan fluorescence spectroscopy reliably determines galectin-ligand interactions
Sindrewicz, P., Li, X., Yates, E. A., Turnbull, J. E., Lian, L. -Y., & Yu, L. -G. (2019). Intrinsic tryptophan fluorescence spectroscopy reliably determines galectin-ligand interactions. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-47658-8
Sulfated polysaccharides interact with fibroblast growth factors and protect from denaturation
Sun, C., Liu, M., Sun, P., Yang, M., Yates, E. A., Guo, Z., & Fernig, D. G. (2019). Sulfated polysaccharides interact with fibroblast growth factors and protect from denaturation. FEBS OPEN BIO, 9(8), 1477-1487. doi:10.1002/2211-5463.12696
A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease
Mycroft-West, C. J., Cooper, L. C., Devlin, A. J., Procter, P., Guimond, S. E., Guerrini, M., . . . Skidmore, M. A. (2019). A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease. MARINE DRUGS, 17(5). doi:10.3390/md17050293
Inhibition of BACE1, the beta-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus
Mycroft-West, C. J., Devlin, A. J., Cooper, L. C., Procter, P., Miller, G. J., Fernig, D. G., . . . Skidmore, M. A. (2019). Inhibition of BACE1, the beta-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus. NEURAL REGENERATION RESEARCH, 15(8), 1546-1553. doi:10.4103/1673-5374.274341
A glycosaminoglycan extract from Portunus pelagicus inhibits BACE1, the β secretase implicated in Alzheimer’s disease
Introduction to the Molecules Special Edition Entitled '<i>Heparan Sulfate and Heparin</i>: <i>Challenges and Controversies</i>': Some Outstanding Questions in Heparan Sulfate and Heparin Research
Yates, E. A., Gallagher, J. T., & Guerrini, M. (2019). Introduction to the Molecules Special Edition Entitled '<i>Heparan Sulfate and Heparin</i>: <i>Challenges and Controversies</i>': Some Outstanding Questions in Heparan Sulfate and Heparin Research. MOLECULES, 24(7). doi:10.3390/molecules24071399
By-Products of Heparin Production Provide a Diverse Source of Heparin-like and Heparan Sulfate Glycosaminoglycans.
Taylor, S. L., Hogwood, J., Guo, W., Yates, E. A., & Turnbull, J. E. (2019). By-Products of Heparin Production Provide a Diverse Source of Heparin-like and Heparan Sulfate Glycosaminoglycans.. Scientific reports, 9(1), 2679. doi:10.1038/s41598-019-39093-6
Low sulfated heparins target multiple proteins for central nervous system repair
McCanney, G. A., McGrath, M. A., Otto, T. D., Burchmore, R., Yates, E. A., Bavington, C. D., . . . Barnett, S. C. (2019). Low sulfated heparins target multiple proteins for central nervous system repair. GLIA, 67(4), 668-687. doi:10.1002/glia.23562
Analysis of solid-state heparin samples by ATR-FTIR spectroscopy
NMR in the Characterization of Complex Mixture Drugs
Guerrini, M., Rudd, T. R., & Yates, E. A. (2019). NMR in the Characterization of Complex Mixture Drugs. In R. Sasisekharan, S. L. Lee, A. Rosenberg, & L. A. Walker (Eds.), The Science and Regulations of Naturally Derived Complex Drugs (Vol. 32, pp. 115-137). Springer International Publishing. doi:10.1007/978-3-030-11751-1_7
2018
Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease
Mycroft-West, C. J., Yates, E. A., & Skidmore, M. A. (2018). Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease. BIOCHEMICAL SOCIETY TRANSACTIONS, 46, 919-929. doi:10.1042/BST20170404
New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors
Byrne, D. P., Li, Y., Ramakrishnan, K., Barsukov, I. L., Yates, E. A., Eyers, C. E., . . . Eyers, P. A. (2018). New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors. BIOCHEMICAL JOURNAL, 475(15), 2417-2433. doi:10.1042/BCJ20180265
Potential role for <i>Streptococcus gordonii</i>-derived hydrogen peroxide in heme acquisition by <i>Porphyromonas gingivalis</i>
Brown, J. L., Yates, E. A., Bielecki, M., Olczak, T., & Smalley, J. W. (2018). Potential role for <i>Streptococcus gordonii</i>-derived hydrogen peroxide in heme acquisition by <i>Porphyromonas gingivalis</i>. MOLECULAR ORAL MICROBIOLOGY, 33(4), 322-335. doi:10.1111/omi.12229
Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection
Vicenzi, E., Pagani, I., Ghezzi, S., Taylor, S. L., Rudd, T. R., Lima, M. A., . . . Yates, E. A. (2018). Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection. BIOCHEMICAL SOCIETY TRANSACTIONS, 46, 609-617. doi:10.1042/BST20170399
An Inexpensive, Pulsed, and Multiple Wavelength Bench-Top Light Source for Biological Spectroscopy
Holman, J., Skidmore, M., & Yates, E. (n.d.). An Inexpensive, Pulsed, and Multiple Wavelength Bench-Top Light Source for Biological Spectroscopy. Plasma, 1(1), 78-89. doi:10.3390/plasma1010008
Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, <i>Glossina morsitans morsitans</i>
Rogerson, E., Pelletier, J., Acosta-Serrano, A., Rose, C., Taylor, S., Guimond, S., . . . Yates, E. (2018). Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, <i>Glossina morsitans morsitans</i>. PATHOGENS, 7(1). doi:10.3390/pathogens7010032
<i>In vitro</i> investigations on the effects of semi-synthetic, sulphated carbohydrates on the immune status of cultured common carp (<i>Cyprinus carpio</i>) leucocytes
Kareem, N., Yates, E., Skidmore, M., & Hoole, D. (2018). <i>In vitro</i> investigations on the effects of semi-synthetic, sulphated carbohydrates on the immune status of cultured common carp (<i>Cyprinus carpio</i>) leucocytes. FISH & SHELLFISH IMMUNOLOGY, 74, 213-222. doi:10.1016/j.fsi.2017.12.047
2017
Coupling of vinculin to F-actin demands Syndecan-4 proteoglycan
Cavalheiro, R. P., Lima, M. A., Jarrouge-Boucas, T. R., Viana, G. M., Lopes, C. C., Coulson-Thomas, V. J., . . . Nader, H. B. (2017). Coupling of vinculin to F-actin demands Syndecan-4 proteoglycan. MATRIX BIOLOGY, 63, 23-37. doi:10.1016/j.matbio.2016.12.006
Identification of Heparin Modifications and Polysaccharide Inhibitors of <i>Plasmodium falciparum</i> Merozoite Invasion That Have Potential for Novel Drug Development
Boyle, M. J., Skidmore, M., Dickerman, B., Cooper, L., Devlin, A., Yates, E., . . . Beeson, J. G. (2017). Identification of Heparin Modifications and Polysaccharide Inhibitors of <i>Plasmodium falciparum</i> Merozoite Invasion That Have Potential for Novel Drug Development. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 61(11). doi:10.1128/AAC.00709-17
Terahertz: dictating the frequency of life. Do macromolecular vibrational modes impose thermal limitations on terrestrial life?
Hand, K., & Yates, E. (2017). Terahertz: dictating the frequency of life. Do macromolecular vibrational modes impose thermal limitations on terrestrial life?. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 14(136). doi:10.1098/rsif.2017.0673
A semi-synthetic glycosaminoglycan analogue inhibits and reverses <i>Plasmodium falciparum</i> cytoadherence
Skidmore, M. A., Mustaffa, K. M. F., Cooper, L. C., Guimond, S. E., Yates, E. A., & Craig, A. G. (2017). A semi-synthetic glycosaminoglycan analogue inhibits and reverses <i>Plasmodium falciparum</i> cytoadherence. PLOS ONE, 12(10). doi:10.1371/journal.pone.0186276
Insights into the role of 3-O-sulfotransferase in heparan sulfate biosynthesis
Zorel Meneghetti, M. C., Ferreira, T. G., Tashima, A. K., Chavante, S. F., Yates, E. A., Liu, J., . . . Lima, M. A. (2017). Insights into the role of 3-O-sulfotransferase in heparan sulfate biosynthesis. ORGANIC & BIOMOLECULAR CHEMISTRY, 15(32), 6792-6799. doi:10.1039/c7ob01533j
Molecular Origins of the Compatibility between Glycosaminoglycans and A beta 40 Amyloid Fibrils
Stewart, K. L., Hughes, E., Yates, E. A., Middleton, D. A., & Radford, S. E. (2017). Molecular Origins of the Compatibility between Glycosaminoglycans and A beta 40 Amyloid Fibrils. JOURNAL OF MOLECULAR BIOLOGY, 429(16), 2449-2462. doi:10.1016/j.jmb.2017.07.003
19F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy
Lima, M. A., Cavalheiro, R. P., M Viana, G., Meneghetti, M. C. Z., Rudd, T. R., Skidmore, M. A., . . . Yates, E. A. (2017). 19F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy. Glycoconjugate Journal, 34, 405-410. doi:10.1007/s10719-016-9723-x
<i>New Methods for the Analysis of Heterogeneous Polysaccharides</i> - Lessons Learned from the Heparin Crisis
Rudd, T. R., Yates, E. A., & Guerrini, M. (2017). <i>New Methods for the Analysis of Heterogeneous Polysaccharides</i> - Lessons Learned from the Heparin Crisis. In NMR IN GLYCOSCIENCE AND GLYCOTECHNOLOGY (Vol. 10, pp. 305-334). Retrieved from https://www.webofscience.com/
CHAPTER 14 New Methods for the Analysis of Heterogeneous Polysaccharides – Lessons Learned from the Heparin Crisis
Rudd, T. R., Yates, E. A., & Guerrini, M. (2017). CHAPTER 14 New Methods for the Analysis of Heterogeneous Polysaccharides – Lessons Learned from the Heparin Crisis. In NMR in Glycoscience and Glycotechnology (pp. 305-334). Royal Society of Chemistry (RSC). doi:10.1039/9781782623946-00305
New Applications of Heparin and Other Glycosaminoglycans
Lima, M., Rudd, T., & Yates, E. (2017). New Applications of Heparin and Other Glycosaminoglycans. MOLECULES, 22(5). doi:10.3390/molecules22050749
The nature of the conserved basic amino acid sequences found among 437 heparin binding proteins determined by network analysis.
Rudd, T. R., Preston, M. D., & Yates, E. A. (2017). The nature of the conserved basic amino acid sequences found among 437 heparin binding proteins determined by network analysis.. Molecular bioSystems, 13(5), 852-865. doi:10.1039/c6mb00857g
Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
Ghezzi, S., Cooper, L., Rubio, A., Pagani, I., Capobianchi, M. R., Ippolito, G., . . . Vicenzi, E. (2017). Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells. Antiviral Research, 140, 13-17. doi:10.1016/j.antiviral.2016.12.023
Investigating the relationship between temperature, conformation and calcium binding in heparin model oligosaccharides
Hughes, A., Meneghetti, M., Huang, T. -Y., Hung, S. -C., Elli, S., Guerrini, M., . . . Yates, E. (2017). Investigating the relationship between temperature, conformation and calcium binding in heparin model oligosaccharides. CARBOHYDRATE RESEARCH, 438, 58-64. doi:10.1016/j.carres.2016.12.002
2016
Nuclear Magnetic Resonance and Molecular Dynamics Simulation of the Interaction between Recognition Protein H7 of the Novel Influenza Virus H7N9 and Glycan Cell Surface Receptors
Macchi, E., Rudd, T. R., Raman, R., Sasisekharan, R., Yates, E. A., Naggi, A., . . . Elli, S. (2016). Nuclear Magnetic Resonance and Molecular Dynamics Simulation of the Interaction between Recognition Protein H7 of the Novel Influenza Virus H7N9 and Glycan Cell Surface Receptors. BIOCHEMISTRY, 55(48), 6605-6616. doi:10.1021/acs.biochem.6b00693
Heparan sulfate and heparin interactions with proteins
Yates, E. A., Meneghetti, M. C. Z., Hughes, A. J., Rudd, T. R., Nader, H. B., Powell, A. K., & Lima, M. A. (2016). Heparan sulfate and heparin interactions with proteins. Journal of the Royal Society Interface. doi:10.1098/rsif.2015.0589
Panels of chemically-modified heparin polysaccharides and natural heparan sulfate saccharides both exhibit differences in binding to Slit and Robo, as well as variation between protein binding and cellular activity
Ahmed, Y. A., Yates, E. A., Moss, D. J., Loeven, M. A., Hussain, S. -A., Hohenester, E., . . . Powell, A. K. (2016). Panels of chemically-modified heparin polysaccharides and natural heparan sulfate saccharides both exhibit differences in binding to Slit and Robo, as well as variation between protein binding and cellular activity. Molecular Biosystems, 12(10), 3166-3175. doi:10.1039/c6mb00432f
Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-beta Fibrils
Stewart, K. L., Hughes, E., Yates, E. A., Akien, G. R., Huang, T. -Y., Lima, M. A., . . . Middleton, D. A. (2016). Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-beta Fibrils. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 138(27), 8328-8331. doi:10.1021/jacs.6b02816
Recent innovations in the structural analysis of heparin.
Yates, E. A., & Rudd, T. R. (2016). Recent innovations in the structural analysis of heparin.. International journal of cardiology, 212 Suppl 1, S5-S9. doi:10.1016/s0167-5273(16)12002-9
JOHANN PETER GRIESS FRS (1829-88): VICTORIAN BREWER AND SYNTHETIC DYE CHEMIST
Yates, E., & Yates, A. (2016). JOHANN PETER GRIESS FRS (1829-88): VICTORIAN BREWER AND SYNTHETIC DYE CHEMIST. NOTES AND RECORDS-THE ROYAL SOCIETY JOURNAL OF THE HISTORY OF SCIENCE, 70(1), 65-81. doi:10.1098/rsnr.2015.0020
Heparin binding preference and structures in the fibroblast growth factor family parallel their evolutionary diversification
Li, Y., Sun, C., Yates, E. A., Jiang, C., Wilkinson, M. C., & Fernig, D. G. (2016). Heparin binding preference and structures in the fibroblast growth factor family parallel their evolutionary diversification. Open Biology, 6(3). doi:10.1098/rsob.150275
Recent innovations in the structural analysis of heparin
Yates, E. A., & Rudd, T. R. (2016). Recent innovations in the structural analysis of heparin. INTERNATIONAL JOURNAL OF CARDIOLOGY, 212, S5-S9. Retrieved from https://www.webofscience.com/
2015
SimpleDSFviewer: a tool to analyse and view differential scanning fluorimetry data for characterising protein thermal stability and interactions
SimpleDSFviewer: a tool to analyse and view differential scanning fluorimetry data for characterising protein thermal stability and interactions
Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis
Duckworth, C. A., Guimond, S. E., Sindrewicz, P., Hughes, A. J., French, N. S., Lian, L. -Y., . . . Yu, L. -G. (2015). Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis. ONCOTARGET, 6(27), 23671-23687. doi:10.18632/oncotarget.4409
Heparan sulfate and heparin interactions with proteins
Meneghetti, M. C. Z., Hughes, A. J., Rudd, T. R., Nader, H. B., Powell, A. K., Yates, E. A., & Lima, M. A. (2015). Heparan sulfate and heparin interactions with proteins. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 12(110). doi:10.1098/rsif.2015.0589
Differentiation of Generic Enoxaparins Marketed in the United States by Employing NMR and Multivariate Analysis
Guerrini, M., Rudd, T. R., Mauri, L., Macchi, E., Fareed, J., Yates, E. A., . . . Torri, G. (2015). Differentiation of Generic Enoxaparins Marketed in the United States by Employing NMR and Multivariate Analysis. ANALYTICAL CHEMISTRY, 87(16), 8275-8283. doi:10.1021/acs.analchem.5b01366
Heparan sulfate and heparin: Structure and function
Lima, M. A., Cavalheiro, R. P., Meneghetti, M. C. Z., Nobre, L. T. D. B., Viana, G. M., Yates, E. A., & Nader, H. B. (2015). Heparan sulfate and heparin: Structure and function. In Sulfated Polysaccharides (pp. 1-16).
Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding
Solari, V., Rudd, T. R., Guimond, S. E., Powell, A. K., Turnbull, J. E., & Yates, E. A. (2015). Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding. ORGANIC & BIOMOLECULAR CHEMISTRY, 13(21), 6066-6072. doi:10.1039/c5ob00564g
Inhibition of influenza H5N1 invasion by modified heparin derivatives
Skidmore, M. A., Kajaste-Rudnitski, A., Wells, N. M., Guimond, S. E., Rudd, T. R., Yates, E. A., & Vicenzi, E. (2015). Inhibition of influenza H5N1 invasion by modified heparin derivatives. MEDCHEMCOMM, 6(4), 640-646. doi:10.1039/c4md00516c
Detection of interaction between protein trytophan residues and small or macromolecular ligands by synchrotron radiation magnetic circular dichroism
Hughes, A. J., Rudd, T. R., Wright, G. S. A., Fernig, D. G., Siligardi, G., & Yates, E. A. (2015). Detection of interaction between protein trytophan residues and small or macromolecular ligands by synchrotron radiation magnetic circular dichroism. ANALYTICAL METHODS, 7(5), 1667-1671. doi:10.1039/c4ay02618g
Heparin derivatives for the targeting of multiple activities in the inflammatory response
Veraldi, N., Hughes, A. J., Rudd, T. R., Thomas, H. B., Edwards, S. W., Hadfield, L., . . . Yates, E. A. (2015). Heparin derivatives for the targeting of multiple activities in the inflammatory response. CARBOHYDRATE POLYMERS, 117, 400-407. doi:10.1016/j.carbpol.2014.09.079
Enhanced Tumorigenic Potential of Colorectal Cancer Cells by Extracellular Sulfatases
Vicente, C. M., Lima, M. A., Yates, E. A., Nader, H. B., & Toma, L. (2015). Enhanced Tumorigenic Potential of Colorectal Cancer Cells by Extracellular Sulfatases. MOLECULAR CANCER RESEARCH, 13(3), 510-523. doi:10.1158/1541-7786.MCR-14-0372
Heparin derivatives for the targeting of multiple activities in the inflammatory response
Veraldi, N., Hughes, A. J., Rudd, T. R., Thomas, H. B., Edwards, S. W., Hadfield, L., . . . Yates, E. A. (2015). Heparin derivatives for the targeting of multiple activities in the inflammatory response. Carbohydrate Polymers, 117, 400-407. doi:10.1016/j.carbpol.2014.09.079
2014
MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival.
Solari, V., Borriello, L., Turcatel, G., Shimada, H., Sposto, R., Esteban Fernandz, G., . . . DeClerck, Y. A. (2014). MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival.. Cancer Research, 74(21), 5999-6009. doi:10.1158/0008-5472.CAN-13-2513
MYCN-dependent expression of sulfatase2 regulates neuroblastoma cell survival
Solari, V., Borriello, L., Fernandez, G. E., Shimada, H., Sposto, R., Asgharzadeh, S., . . . Declerck, Y. A. (2014). MYCN-dependent expression of sulfatase2 regulates neuroblastoma cell survival. CANCER RESEARCH, 74(19). doi:10.1158/1538-7445.AM2014-3963
Monovalent maleimide functionalization of gold nanoparticles via copper-free click chemistry
Nieves, D., Azmi, N., Xu, R., Levy, R., Yates, E., & Fernig, D. (2014). Monovalent maleimide functionalization of gold nanoparticles via copper-free click chemistry. Chemical Communications, 50(86), 13157-13160. doi:10.1039/c4cc05909c
Insights into the human glycan receptor conformation of 1918 pandemic hemagglutinin-glycan complexes derived from nuclear magnetic resonance and molecular dynamics studies.
Elli, S., Macchi, E., Rudd, T. R., Rahman, R., Sassaki, G., Viswanathan, K., . . . Guerrini, M. (2014). Insights into the human glycan receptor conformation of 1918 pandemic hemagglutinin-glycan complexes derived from nuclear magnetic resonance and molecular dynamics studies.. Biochemistry, 53(25), 4122-4135. doi:10.1021/bi500338r
A heparin-like glycosaminoglycan from shrimp containing high levels of 3-O-sulfated D-glucosamine groups in an unusual trisaccharide sequence
Chavante, S. F., Brito, A. S., Lima, M., Yates, E., Nader, H., Guerrini, M., . . . Bisio, A. (2014). A heparin-like glycosaminoglycan from shrimp containing high levels of 3-O-sulfated D-glucosamine groups in an unusual trisaccharide sequence. CARBOHYDRATE RESEARCH, 390, 59-66. doi:10.1016/j.carres.2014.03.002
A heparin-like glycosaminoglycan from shrimp containing high levels of 3-O-sulfated d-glucosamine groups in an unusual trisaccharide sequence
Chavante, S. F., Brito, A. S., Lima, M., Yates, E., Nader, H., Guerrini, M., . . . Bisio, A. (2014). A heparin-like glycosaminoglycan from shrimp containing high levels of 3-O-sulfated d-glucosamine groups in an unusual trisaccharide sequence. Carbohydrate Research, 390, 59-66. doi:10.1016/j.carres:2014.03.002
A non-hemorrhagic hybrid heparin/heparan sulfate with anticoagulant potential
Brito, A. S., Cavalcante, R. S., Palhares, L. C. G. F., Hughes, A. J., Andrade, G. P. V., Yates, E. A., . . . Chavante, S. F. (2014). A non-hemorrhagic hybrid heparin/heparan sulfate with anticoagulant potential. Carbohydrate Polymers.
A non-hemorrhagic hybrid heparin/heparan sulfate with anticoagulant potential
Brito, A. S., Cavalcante, R. S., Palhares, L. C. G. F., Hughes, A. J., Andrade, G. P. V., Yates, E. A., . . . Chavante, S. F. (2014). A non-hemorrhagic hybrid heparin/heparan sulfate with anticoagulant potential. CARBOHYDRATE POLYMERS, 99, 372-378. doi:10.1016/j.carbpol.2013.08.063
Characterisation of the interaction of neuropilin-1 with heparin and a heparan sulfate mimetic library of heparin-derived sugars
Uniewicz, K. A., Ori, A., Ahmed, Y. A., Yates, E. A., & Fernig, D. G. (2014). Characterisation of the interaction of neuropilin-1 with heparin and a heparan sulfate mimetic library of heparin-derived sugars. PEERJ, 2. doi:10.7717/peerj.461
Dicroismo Circular
Lima, M. A., Yates, E. A., Tersariol, I. L. S., & Nader, H. B. (2014). Dicroismo Circular. In H. Verli (Ed.), Bioinformatica a Flexibilidade Molecular (pp. 219-228). Porto Alegre: Universidade Federal do Rio Grande do Sul.
Heparin Derivatives for the Targeting of Multiple Activities in the Inflammatory Response
Veraldi, N., Hughes, A. J., Rudd, T. R., Thomas, H. B., Edwards, S. W., Hadfield, L., . . . Yates, E. A. (2014). Heparin Derivatives for the Targeting of Multiple Activities in the Inflammatory Response. Carbohydrate Polymers.
MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival
Solari, V., Borriello, L., Turcatel, G., Shimada, H., Sposto, R., Esteban Fernandz, G., . . . DeClerck, Y. A. (2014). MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival. Cancer Research.
Monovalent maleimide functionalization of gold nanoparticles via copper-free click chemistry: A route to covalent nanoparticle-biomolecule conjugates.
Nieves, D. J., Azmi, N. S., Xu, R., Lévy, R., Yates, E. A., & Fernig, D. G. (2014). Monovalent maleimide functionalization of gold nanoparticles via copper-free click chemistry: A route to covalent nanoparticle-biomolecule conjugates.. Chemical Communications (Cambridge).
On the catalytic mechanism of polysaccharide lyases: evidence of His and Tyr involvement in heparin lysis by heparinase I and the role of Ca<SUP>2+</SUP>
Cordula, C. R., Lima, M. A., Shinjo, S. K., Gesteira, T. F., Pol-Fachin, L., Coulson-Thomas, V. J., . . . Tersariol, I. L. S. (2014). On the catalytic mechanism of polysaccharide lyases: evidence of His and Tyr involvement in heparin lysis by heparinase I and the role of Ca<SUP>2+</SUP>. MOLECULAR BIOSYSTEMS, 10(1), 54-64. doi:10.1039/c3mb70370c
2013
Human (α2→6) and Avian (α2→3) Sialylated Receptors of Influenza A Virus Show Distinct Conformations and Dynamics in Solution
Sassaki, G. L., Elli, S., Rudd, T. R., Macchi, E., Yates, E. A., Naggi, A., . . . Guerrini, M. (2013). Human (α2→6) and Avian (α2→3) Sialylated Receptors of Influenza A Virus Show Distinct Conformations and Dynamics in Solution. BIOCHEMISTRY, 52(41), 7217-7230. doi:10.1021/bi400677n
Unravelling Structural Information from Complex Mixtures Utilizing Correlation Spectroscopy Applied to HSQC Spectra
Rudd, T. R., Macchi, E., Muzi, L., Ferro, M., Gaudesi, D., Torri, G., . . . Yates, E. A. (2013). Unravelling Structural Information from Complex Mixtures Utilizing Correlation Spectroscopy Applied to HSQC Spectra. ANALYTICAL CHEMISTRY, 85(15), 7487-7493. doi:10.1021/ac4014379
Analysis of the fibroblast growth factor receptor (FGFR) signalling network with heparin as coreceptor: evidence for the expansion of the core FGFR signalling network
Xu, R., Rudd, T. R., Hughes, A. J., Siligardi, G., Fernig, D. G., & Yates, E. A. (2013). Analysis of the fibroblast growth factor receptor (FGFR) signalling network with heparin as coreceptor: evidence for the expansion of the core FGFR signalling network. FEBS JOURNAL, 280(10), 2260-2270. doi:10.1111/febs.12201
Antithrombin stabilisation by sulfated carbohydrates correlates with anticoagulant activity
Lima, M. A., Hughes, A. J., Veraldi, N., Rudd, T. R., Hussain, R., Brito, A. S., . . . Yates, E. A. (2013). Antithrombin stabilisation by sulfated carbohydrates correlates with anticoagulant activity. MEDCHEMCOMM, 4(5), 870-873. doi:10.1039/c3md00048f
Human (α2→6) and avian (α2→3) sialylated receptors of influenza A virus show distinct conformations and dynamics in solution
Sassaki, G., Elli, S., Rudd, T., Macchi, E., Yates, E., Naggi, A., . . . Guerrini, M. (2013). Human (α2→6) and avian (α2→3) sialylated receptors of influenza A virus show distinct conformations and dynamics in solution. Biochemistry, 52, 7217-7230. doi:10.1021/bi4000677n
2012
Site-Specific Identification of an Aß Fibril-Heparin Interaction Site by Using Solid-State NMR Spectroscopy
Madine, J., Pandya, M. J., Hicks, M. R., Rodger, A., Yates, E. A., Radford, S. E., & Middleton, D. A. (2012). Site-Specific Identification of an Aß Fibril-Heparin Interaction Site by Using Solid-State NMR Spectroscopy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(52), 13140-13143. doi:10.1002/anie.201204459
Site‐Specific Identification of an Aβ Fibril–Heparin Interaction Site by Using Solid‐State NMR Spectroscopy
Madine, J., Pandya, M. J., Hicks, M. R., Rodger, A., Yates, E. A., Radford, S. E., & Middleton, D. A. (2012). Site‐Specific Identification of an Aβ Fibril–Heparin Interaction Site by Using Solid‐State NMR Spectroscopy. Angewandte Chemie, 124(52), 13317-13320. doi:10.1002/ange.201204459
Diversification of the Structural Determinants of Fibroblast Growth Factor-Heparin Interactions <i>IMPLICATIONS FOR BINDING SPECIFICITY</i>
Xu, R., Ori, A., Rudd, T. R., Uniewicz, K. A., Ahmed, Y. A., Guimond, S. E., . . . Fernig, D. G. (2012). Diversification of the Structural Determinants of Fibroblast Growth Factor-Heparin Interactions <i>IMPLICATIONS FOR BINDING SPECIFICITY</i>. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(47). doi:10.1074/jbc.M112.398826
A zinc complex of heparan sulfate destabilises lysozyme and alters its conformation
Hughes, A. J., Hussain, R., Cosentino, C., Guerrini, M., Siligardi, G., Yates, E. A., & Rudd, T. R. (2012). A zinc complex of heparan sulfate destabilises lysozyme and alters its conformation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 425(4), 794-799. doi:10.1016/j.bbrc.2012.07.154
How To Find a Needle (or Anything Else) in a Haystack: Two-Dimensional Correlation Spectroscopy-Filtering with Iterative Random Sampling Applied to Pharmaceutical Heparin
Rudd, T. R., Macchi, E., Gardini, C., Muzi, L., Guerrini, M., Yates, E. A., & Torri, G. (2012). How To Find a Needle (or Anything Else) in a Haystack: Two-Dimensional Correlation Spectroscopy-Filtering with Iterative Random Sampling Applied to Pharmaceutical Heparin. ANALYTICAL CHEMISTRY, 84(15), 6841-6847. doi:10.1021/ac301428d
Fundamental differences in model cell-surface polysaccharides revealed by complementary optical and spectroscopic techniques
Holder, G. M., Bowfield, A., Surman, M., Suepfle, M., Moss, D., Tucker, C., . . . Weightman, P. (2012). Fundamental differences in model cell-surface polysaccharides revealed by complementary optical and spectroscopic techniques. SOFT MATTER, 8(24), 6521-6527. doi:10.1039/c2sm25239b
A highly efficient tree structure for the biosynthesis of heparan sulfate accounts for the commonly observed disaccharides and suggests a mechanism for domain synthesis
Rudd, T. R., & Yates, E. A. (2012). A highly efficient tree structure for the biosynthesis of heparan sulfate accounts for the commonly observed disaccharides and suggests a mechanism for domain synthesis. MOLECULAR BIOSYSTEMS, 8(5), 1499-1506. doi:10.1039/c2mb25019e
Following Protein-Glycosaminoglycan Polysaccharide Interactions with Differential Scanning Fluorimetry
Uniewicz, K. A., Ori, A., Rudd, T. R., Guerrini, M., Wilkinson, M. C., Fernig, D. G., & Yates, E. A. (2012). Following Protein-Glycosaminoglycan Polysaccharide Interactions with Differential Scanning Fluorimetry. PROTEOGLYCANS: METHODS AND PROTOCOLS, 836, 171-182. doi:10.1007/978-1-61779-498-8_12
<i>Clostridium difficile</i>: a problem of concern in developed countries and still a mystery in Latin America
Balassiano, I. T., Yates, E. A., Domingues, R. M. C. P., & Ferreira, E. O. (2012). <i>Clostridium difficile</i>: a problem of concern in developed countries and still a mystery in Latin America. JOURNAL OF MEDICAL MICROBIOLOGY, 61(2), 169-179. doi:10.1099/jmm.0.037077-0
Following Protein-Glycosaminoglycan Polysaccharide Interactions with Differential Scanning Fluorimetry
Uniewicz, K. A., Ori, A., Rudd, T. R., Guerrini, M., Wilkinson, M. C., Fernig, D. G., & Yates, E. A. (2012). Following Protein-Glycosaminoglycan Polysaccharide Interactions with Differential Scanning Fluorimetry. In F. Redini, & J. M. Walker (Eds.), Proteoglycans: methods and Protocols (pp. 171-182). New York: Humana Press, Springer.
Heparan sulphate, its derivatives and analogues share structural characteristics that can be exploited, particularly in inhibiting microbial attachment
Rudd, T. R., Hughes, A., Holman, J., de Oliveira Ferreira, E., Cavalcante Pilotto Domingues, R. M., & Yates, E. A. (2012). Heparan sulphate, its derivatives and analogues share structural characteristics that can be exploited, particularly in inhibiting microbial attachment. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 45(5), 386-391. doi:10.1590/S0100-879X2012007500048
Ordering and motional characteristics of extracellular matrix polysaccharides revealed by complementary optical and spectroscopic techniques
Holder, G. M., Bowfield, A., Surman, M., Suepfle, M., Moss, D., Rudd, T. R., . . . Weightman, P. (2012). Ordering and motional characteristics of extracellular matrix polysaccharides revealed by complementary optical and spectroscopic techniques. Soft Matter, 8, 6521.
Pinpointing the Abeta fibril-glycosaminoglycan interaction site using linear dichroism and solid state NMR
Madine, J., Pandya, M. J., Hicks, M. R., Rodger, A., Yates, E. A., Radford, S. E., & Middleton, D. A. (2012). Pinpointing the Abeta fibril-glycosaminoglycan interaction site using linear dichroism and solid state NMR. Angewandte Chemie.
2011
Low molecular weight heparins: Structural differentiation by spectroscopic and multivariate approaches
Lima, M. A., de Farias, E. H. C., Rudd, T. R., Ebner, L. F., Gesteira, T. F., Mendes, A., . . . Nader, H. B. (2011). Low molecular weight heparins: Structural differentiation by spectroscopic and multivariate approaches. CARBOHYDRATE POLYMERS, 85(4), 903-909. doi:10.1016/j.carbpol.2011.04.021
A robust method to quantify low molecular weight contaminants in heparin: detection of tris(2-<i>n</i>-butoxyethyl) phosphate
Sassaki, G. L., Riter, D. S., Santana Filho, A. P., Guerrini, M., Lima, M. A., Cosentino, C., . . . Iacomini, M. (2011). A robust method to quantify low molecular weight contaminants in heparin: detection of tris(2-<i>n</i>-butoxyethyl) phosphate. ANALYST, 136(11), 2330-2338. doi:10.1039/c0an01010c
Construction and use of a library of <i>bona fide</i> heparins employing <SUP>1</SUP>H NMR and multivariate analysis
Rudd, T. R., Gaudesi, D., Skidmore, M. A., Ferro, M., Guerrini, M., Mulloy, B., . . . Yates, E. A. (2011). Construction and use of a library of <i>bona fide</i> heparins employing <SUP>1</SUP>H NMR and multivariate analysis. ANALYST, 136(7), 1380-1389. doi:10.1039/c0an00834f
High-sensitivity visualisation of contaminants in heparin samples by spectral filtering of <SUP>1</SUP>H NMR spectra
Rudd, T. R., Gaudesi, D., Lima, M. A., Skidmore, M. A., Mulloy, B., Torri, G., . . . Yates, E. A. (2011). High-sensitivity visualisation of contaminants in heparin samples by spectral filtering of <SUP>1</SUP>H NMR spectra. ANALYST, 136(7), 1390-1398. doi:10.1039/c0an00835d
Anaerobe/aerobe environmental flux determines protein expression profiles of <i>Bacteroides fragilis</i>, a redox pathogen
Ferreira, E. D. O., Yates, E., Jourlin, M., Liu, J., Pilotto Domingues, R. M. C., & Goldner, M. (2011). Anaerobe/aerobe environmental flux determines protein expression profiles of <i>Bacteroides fragilis</i>, a redox pathogen. ANAEROBE, 17(1), 4-14. doi:10.1016/j.anaerobe.2010.09.004
A New Approach for Heparin Standardization: Combination of Scanning UV Spectroscopy, Nuclear Magnetic Resonance and Principal Component Analysis
Lima, M. A., Rudd, T. R., de Farias, E. H. C., Ebner, L. F., Gesteira, T. F., de Souza, L. M., . . . Nader, H. B. (2011). A New Approach for Heparin Standardization: Combination of Scanning UV Spectroscopy, Nuclear Magnetic Resonance and Principal Component Analysis. PLOS ONE, 6(1). doi:10.1371/journal.pone.0015970
Construction and use of a library of bona fide heparins employing 1H NMR and multivariate analysis.
Rudd, T. R., Gaudesi, D., Skidmore, M. A., Ferro, M., Guerrini, M., Mulloy, B., . . . Yates, E. A. (2011). Construction and use of a library of bona fide heparins employing 1H NMR and multivariate analysis.. Analyst. doi:10.0139/c0an00834f
2010
Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships
Rudd, T. R., Uniewicz, K. A., Ori, A., Guimond, S. E., Skidmore, M. A., Gaudesi, D., . . . Yates, E. A. (2010). Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships. ORGANIC & BIOMOLECULAR CHEMISTRY, 8(23), 5390-5397. doi:10.1039/c0ob00246a
Disaccharide compositional analysis of heparan sulfate and heparin polysaccharides using UV or high-sensitivity fluorescence (BODIPY) detection
Skidmore, M. A., Guimond, S. E., Dumax-Vorzet, A. F., Yates, E. A., & Turnbull, J. E. (2010). Disaccharide compositional analysis of heparan sulfate and heparin polysaccharides using UV or high-sensitivity fluorescence (BODIPY) detection. Nature Protocols, 5(12), 1983-1992. doi:10.1038/nprot.2010.145
Disaccharide compositional analysis of heparan sulfate and heparin polysaccharides using UV or high-sensitivity fluorescence (BODIPY) detection
Skidmore, M. A., Guimond, S. E., Dumax-Vorzet, A. F., Yates, E. A., & Turnbull, J. E. (2010). Disaccharide compositional analysis of heparan sulfate and heparin polysaccharides using UV or high-sensitivity fluorescence (BODIPY) detection. NATURE PROTOCOLS, 5(12), 1983-1992. doi:10.1038/nprot.2010.145
The conformation and structure of GAGs: recent progress and perspectives
Rudd, T. R., Skidmore, M. A., Guerrini, M., Hricovini, M., Powell, A. K., Siligardi, G., & Yates, E. A. (2010). The conformation and structure of GAGs: recent progress and perspectives. CURRENT OPINION IN STRUCTURAL BIOLOGY, 20(5), 567-574. doi:10.1016/j.sbi.2010.08.004
The latent ampholytic nature of glycosaminoglycan (GAG) oligosaccharides facilitates their separation by isoelectric focusing
Holman, J., Skidmore, M. A., Rudd, T. R., & Yates, E. A. (2010). The latent ampholytic nature of glycosaminoglycan (GAG) oligosaccharides facilitates their separation by isoelectric focusing. ANALYTICAL METHODS, 2(10), 1550-1554. doi:10.1039/c0ay00340a
Determining the anti-coagulant-independent anti-cancer effects of heparin
Solari, V., Jesudason, E. C., Turnbull, J. E., & Yates, E. A. (2010). Determining the anti-coagulant-independent anti-cancer effects of heparin. British Journal of Cancer, 103(4), 593-594. doi:10.1038/sj.bjc.6605808
Determining the anti-coagulant-independent anti-cancer effects of heparin
Solari, V., Jesudason, E. C., Turnbull, J. E., & Yates, E. A. (2010). Determining the anti-coagulant-independent anti-cancer effects of heparin. BRITISH JOURNAL OF CANCER, 103(4), 593-594. doi:10.1038/sj.bjc.6605808
Raman and Raman optical activity of glycosaminoglycans
Rudd, T. R., Hussain, R., Siligardi, G., & Yates, E. A. (2010). Raman and Raman optical activity of glycosaminoglycans. CHEMICAL COMMUNICATIONS, 46(23), 4124-4126. doi:10.1039/c001535k
Conformational degeneracy restricts the effective information content of heparan sulfate
Rudd, T. R., & Yates, E. A. (2010). Conformational degeneracy restricts the effective information content of heparan sulfate. MOLECULAR BIOSYSTEMS, 6(5), 902-908. doi:10.1039/b923519a
Differential Scanning Fluorimetry Measurement of Protein Stability Changes upon Binding to Glycosaminoglycans: A Screening Test for Binding Specificity
Uniewicz, K. A., Ori, A., Xu, R., Ahmed, Y., Wilkinson, M. C., Fernig, D. G., & Yates, E. A. (2010). Differential Scanning Fluorimetry Measurement of Protein Stability Changes upon Binding to Glycosaminoglycans: A Screening Test for Binding Specificity. ANALYTICAL CHEMISTRY, 82(9), 3796-3802. doi:10.1021/ac100188x
Generating heparan sulfate saccharide libraries for glycomics applications
Powell, A. K., Ahmed, Y. A., Yates, E. A., & Turnbull, J. E. (2010). Generating heparan sulfate saccharide libraries for glycomics applications. Nature Protocols, 5(5), 821-833. doi:10.1038/nprot.2010.17
Generating heparan sulfate saccharide libraries for glycomics applications
Powell, A. K., Ahmed, Y. A., Yates, E. A., & Turnbull, J. E. (2010). Generating heparan sulfate saccharide libraries for glycomics applications. NATURE PROTOCOLS, 5(5), 821-833. doi:10.1038/nprot.2010.17
'Differential Scanning Fluorimetry measurement of protein stability changes upon binding to glycosaminoglycans: a rapid screening test for binding specificity'
Uniewicz, K. A., Ori, A., Xu, R., Ahmed, Y., Fernig, D. G., & Yates, E. A. (2010). 'Differential Scanning Fluorimetry measurement of protein stability changes upon binding to glycosaminoglycans: a rapid screening test for binding specificity'. Analytical Chemistry, 82, 3796-3802.
A key biological signalling system promises new routes to intervention in medically important processes
Rudd, T. R., Skidmore, M. A., Guimond, S. E., Xu, R., Hussain, R., Fernig, D. G., . . . Yates, E. A. (2010). A key biological signalling system promises new routes to intervention in medically important processes. Didcot, Oxfordshire: Diamond light Source Ltd.,.
Carbohydrate composition analysis of heparin and heparan sulphate derived polymers
Skidmore, M. A., Guimond, S. E., Dumax-Vorzet, A. F., Yates, E. A., & Turnbull, J. E. (2010). Carbohydrate composition analysis of heparin and heparan sulphate derived polymers. Nature Protocols.
Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships
Rudd, T. R., Uniewicz, K. A., Ori, A., Guimond, S. E., Skidmore, M. A., Gaudesi, D., . . . Yates, E. A. (2010). Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships. Organic & Biomolecular Chemistry, 8(23), 5390. doi:10.1039/c0ob00246a
Disaccharide compositional analysis of HS and heparin polysaccharides using UV and high sensitivity fluorescence analysis
Skidmore, M. A., Guimond, S. E., Dumax-Vorzet, F., Yates, E. A., & Turnbull, J. E. (2010). Disaccharide compositional analysis of HS and heparin polysaccharides using UV and high sensitivity fluorescence analysis. Nature Protocols.
Generating heparan sulfate saccharide libraries for glycomics screening
Powell, A. K., Ahmed, Y. A., Yates, E. A., & Turnbull, J. E. (2010). Generating heparan sulfate saccharide libraries for glycomics screening. Nature protocols, 5, 829.
The conformation and structure of GAGs: recent progress and perspectives
Rudd, T. R., Skidmore, M. A., Guerrini, M., Hricovini, M., Powell, A. K., Guimoind, S. E., & Yates, E. A. (2010). The conformation and structure of GAGs: recent progress and perspectives. Current Opinion in Structural Biology.
2009
Labelling heparan sulphate saccharides with chromophore, fluorescence and mass tags for HPLC and MS separations.
Skidmore, M., Atrih, A., Yates, E., & Turnbull, J. E. (2009). Labelling heparan sulphate saccharides with chromophore, fluorescence and mass tags for HPLC and MS separations.. Methods in molecular biology (Clifton, N.J.), 534, 157-169. doi:10.1007/978-1-59745-022-5_12
Spectroscopic and Theoretical Approaches for the Determination of Heparin Saccharide Structure and the Study of Protein-Glycosaminoglycan Complexes in Solution
Rudd, T. R., Yates, E. A., & Hricovini, M. (2009). Spectroscopic and Theoretical Approaches for the Determination of Heparin Saccharide Structure and the Study of Protein-Glycosaminoglycan Complexes in Solution. CURRENT MEDICINAL CHEMISTRY, 16(35), 4750-4766. doi:10.2174/092986709789878193
The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids
Rudd, T. R., Skidmore, M. A., Guimond, S. E., Holman, J., Turnbull, J. E., Lauder, R. M., . . . Yates, E. A. (2009). The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids. THROMBOSIS AND HAEMOSTASIS, 102(5), 874-878. doi:10.1160/TH08-12-0797
The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids
Guimond, S., Holman, J., Turnbull, J., Lauder, R., Fernig, D., Rudd, T., . . . Yates, E. (2009). The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids. Thrombosis and Haemostasis, 102(11), 874-878. doi:10.1160/th08-12-0797
Rapid Purification and High Sensitivity Analysis of Heparan Sulfate from Cells and Tissues <i>TOWARD GLYCOMICS PROFILING</i>
Guimond, S. E., Puvirajesinghe, T. M., Skidmore, M. A., Kalus, I., Dierks, T., Yates, E. A., & Turnbull, J. E. (2009). Rapid Purification and High Sensitivity Analysis of Heparan Sulfate from Cells and Tissues <i>TOWARD GLYCOMICS PROFILING</i>. JOURNAL OF BIOLOGICAL CHEMISTRY, 284(38), 25714-25722. doi:10.1074/jbc.M109.032755
Cations Modulate Polysaccharide Structure To Determine FGF-FGFR Signaling: A Comparison of Signaling and Inhibitory Polysaccharide Interactions with FGF-1 in Solution
Guimond, S. E., Rudd, T. R., Skidmore, M. A., Ori, A., Gaudesi, D., Cosentino, C., . . . Yates, E. A. (2009). Cations Modulate Polysaccharide Structure To Determine FGF-FGFR Signaling: A Comparison of Signaling and Inhibitory Polysaccharide Interactions with FGF-1 in Solution. BIOCHEMISTRY, 48(22), 4772-4779. doi:10.1021/bi802318z
Exploiting a <SUP>13</SUP>C-labelled heparin analogue for <i>in situ</i> solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils
Madine, J., Clayton, J. C., Yates, E. A., & Middleton, D. A. (2009). Exploiting a <SUP>13</SUP>C-labelled heparin analogue for <i>in situ</i> solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils. ORGANIC & BIOMOLECULAR CHEMISTRY, 7(11), 2414-2420. doi:10.1039/b820808e
Glycosaminoglycan origin and structure revealed by multivariate analysis of NMR and CD spectra
Rudd, T. R., Skidmore, M. A., Guimond, S. E., Cosentino, C., Torri, G., Fernig, D. G., . . . Yates, E. A. (2009). Glycosaminoglycan origin and structure revealed by multivariate analysis of NMR and CD spectra. GLYCOBIOLOGY, 19(1), 52-67. doi:10.1093/glycob/cwn103
Rapid purification and high sensitivity analysis of heparan sulfate from cells and tissues: toward glycomics profiling
Guimond, S. E., Puvirajesinghe, T. M., Skidmore, M. A., Kalus, I., Dierks, T., Yates, E. A., & Turnbull, J. E. (2009). Rapid purification and high sensitivity analysis of heparan sulfate from cells and tissues: toward glycomics profiling. Journal of Biological Chemistry.
2008
Software Tool for the Structural Determination of Glycosaminoglycans by Mass Spectrometry
Tissot, B., Ceroni, A., Powell, A. K., Morris, H. R., Yates, E. A., Turnbull, J. E., . . . Haslam, S. M. (2008). Software Tool for the Structural Determination of Glycosaminoglycans by Mass Spectrometry. ANALYTICAL CHEMISTRY, 80(23), 9204-9212. doi:10.1021/ac8013753
Site-specific interactions of copper(II) ions with heparin revealed with complementary (SRCD, NMR, FTIR and EPR) spectroscopic techniques
Rudd, T. R., Skidmore, M. A., Guimond, S. E., Guerrini, M., Cosentino, C., Edge, R., . . . Yates, E. A. (2008). Site-specific interactions of copper(II) ions with heparin revealed with complementary (SRCD, NMR, FTIR and EPR) spectroscopic techniques. CARBOHYDRATE RESEARCH, 343(12), 2184-2193. doi:10.1016/j.carres.2007.12.019
The activities of heparan sulfate and its analogue heparin are dictated by biosynthesis, sequence, and conformation
Skidmore, M. A., Guimond, S. E., Rudd, T. R., Fernig, D. G., Turnbull, J. E., & Yates, E. A. (2008). The activities of heparan sulfate and its analogue heparin are dictated by biosynthesis, sequence, and conformation. CONNECTIVE TISSUE RESEARCH, 49(3-4), 140-144. doi:10.1080/03008200802148595
Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation
Patel, V. N., Likar, K. M., Zisman-Rozen, S., Cowherd, S. N., Lassiter, K. S., Sher, I., . . . Hoffman, M. P. (2008). Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(14), 9308-9317. doi:10.1074/jbc.M709995200
Disruption of rosetting in <i>Plasmodium falciparum</i> malaria with chemically modified heparin and low molecular weight derivatives possessing reduced anticoagulant and other serine protease inhibition activities
Skidmore, M. A., Dumax-Vorzet, A. F., Guimond, S. E., Rudd, T. R., Edwards, E. A., Turnbull, J. E., . . . Yates, E. A. (2008). Disruption of rosetting in <i>Plasmodium falciparum</i> malaria with chemically modified heparin and low molecular weight derivatives possessing reduced anticoagulant and other serine protease inhibition activities. JOURNAL OF MEDICINAL CHEMISTRY, 51(5), 1453-1458. doi:10.1021/jm701337t
Engineered heparins:: Novel β-secretase inhibitors as potential Alzheimer's disease therapeutics
Patey, S. J., Edwards, E. A., Yates, E. A., & Turnbull, J. E. (2008). Engineered heparins:: Novel β-secretase inhibitors as potential Alzheimer's disease therapeutics. NEURODEGENERATIVE DISEASES, 5(3-4), 197-199. doi:10.1159/000113701
Selective detection of protein secondary structural changes in solution protein-polysaccharide complexes using vibrational circular dichroism (VCD)
Rudd, T. R., Nichols, R. J., & Yates, E. A. (2008). Selective detection of protein secondary structural changes in solution protein-polysaccharide complexes using vibrational circular dichroism (VCD). JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(7), 2138-+. doi:10.1021/ja077675n
The redox potential interferes with the expression of laminin binding molecules in <i>Bacteroides fragilis</i>
de Oliveira Ferreira, E., Yates, E. A., Goldner, M., Vommaro, R. C., Costa e Silva Filho, F., Petropolis, D. B., & Pilotto Domingues, R. M. C. (2008). The redox potential interferes with the expression of laminin binding molecules in <i>Bacteroides fragilis</i>. MEMORIAS DO INSTITUTO OSWALDO CRUZ, 103(7), 683-689. Retrieved from https://www.webofscience.com/
2007
Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives
Rudd, T. R., Guimond, S. E., Skidmore, M. A., Duchesne, L., Guerrini, M., Torri, G., . . . Yates, E. A. (2007). Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives. GLYCOBIOLOGY, 17(9), 983-993. doi:10.1093/glycob/cwm062
Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives.
Rudd, T. R., Guimond, S. E., Skidmore, M. A., Duchesne, L., Guerrini, M., Torri, G., . . . Yates, E. A. (2007). Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives.. Glycobiology, 17(9), 983-993. doi:10.1093/glycob/cwm062
Site-specific interactions of copper (II) ions with heparin revealed with complementary
Rudd, T. R., Skidmore, M. A., Guimond, S. E., Guerrini, M., Cosentino, C., Edge, R., . . . Yates, E. A. (2007). Site-specific interactions of copper (II) ions with heparin revealed with complementary. Carbohydrate Research. Retrieved from doi:10.1016/j.carres.2007.12.0
2006
High sensitivity separation and detection of heparan sulfate disaccharides
Skidmore, M. A., Guimond, S. E., Dumax-Vorzet, A. F., Atrih, A., Yates, E. A., & Turnbull, J. E. (2006). High sensitivity separation and detection of heparan sulfate disaccharides. JOURNAL OF CHROMATOGRAPHY A, 1135(1), 52-56. doi:10.1016/j.chroma.2006.09.064
Heparin derivatives as inhibitors of BACE-1, the Alzheimer's β-secretase, with reduced activity against factor Xa and other proteases
Patey, S. J., Edwards, E. A., Yates, E. A., & Turnbull, J. E. (2006). Heparin derivatives as inhibitors of BACE-1, the Alzheimer's β-secretase, with reduced activity against factor Xa and other proteases. JOURNAL OF MEDICINAL CHEMISTRY, 49(20), 6129-6132. doi:10.1021/jm051221o
Engineered bio-active polysaccharides from heparin
Guimond, S. E., Turnbull, J. E., & Yates, E. A. (2006). Engineered bio-active polysaccharides from heparin. MACROMOLECULAR BIOSCIENCE, 6(8), 681-686. doi:10.1002/mabi.200600042
P4–250: Assessment of heparan–mimetics as novel Alzheimer therapeutics
Talbot, C. J., Hazeel, C., Patey, S., Yates, E., & Turnbull, J. (2006). P4–250: Assessment of heparan–mimetics as novel Alzheimer therapeutics. Alzheimer's & Dementia, 2(3S_Part_19). doi:10.1016/j.jalz.2006.05.1989
P4–304: Novel beta–secretase inhibitors: Development of heparin analogues as Alzheimer's therapeutics
Patey, S. J., Yates, E. A., Edwards, E. A., Hazeel, C., Talbot, C., & Turnbull, J. E. (2006). P4–304: Novel beta–secretase inhibitors: Development of heparin analogues as Alzheimer's therapeutics. Alzheimer's & Dementia, 2(3S_Part_20). doi:10.1016/j.jalz.2006.05.2045
Protein-GAG interactions: new surface-based techniques, spectroscopies and nanotechnology probes
Yates, E. A., Terry, C. J., Rees, C., Rudd, T. R., Duchesne, L., Skidmore, M. A., . . . Fernig, D. G. (2006). Protein-GAG interactions: new surface-based techniques, spectroscopies and nanotechnology probes. In BIOCHEMICAL SOCIETY TRANSACTIONS Vol. 34 (pp. 427-430). doi:10.1042/BST0340427
Heparin derivatives as inhibitors of BACE-1, the Alzheimer's beta-secretase with reduced activity against factor Xa and other proteases
Patey, S. J., Edwards, E. A., Yates, E. A., & Turnbull, J. E. (2006). Heparin derivatives as inhibitors of BACE-1, the Alzheimer's beta-secretase with reduced activity against factor Xa and other proteases. Journal of medicinal chemistry, in pre.
Oligosaccharides as novel agents for treating Alzheimer's disease
Turnbull, J. E., Patey, S. J., & Yates, E. A. (2006). Oligosaccharides as novel agents for treating Alzheimer's disease. Unknown Journal, UK Pat.
Role of heparan sulphates in neuronal stem cell differentiation
Turnbull, J. E., Hemers, E., Limaye, P., Burrell, H., Drummond, K., Wells, N., . . . Murray, P. (2006). Role of heparan sulphates in neuronal stem cell differentiation. Endocrine Abstracts, 11, S38.
Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Consideartions for Surface Immobilisation of HS/Heparin Saccharides and Monitoring their Interactions with Binding Proteins
Rudd, T. R., Skidmore, M. A., & Yates, E. A. (2006). Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Consideartions for Surface Immobilisation of HS/Heparin Saccharides and Monitoring their Interactions with Binding Proteins. In H. Garg, R. Linhardt, & C. Hales (Eds.), Chemistry and biology of heparin and heparan sulfate (pp. Chapter 12). Oxford: Elsevier.
2005
Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Considerations for Surface Immobilisation of HS/Heparin Saccharides and Monitoring Their Interactions with Binding Proteins
Rudd, T., Skidmore, M. A., & Yates, E. A. (2005). Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Considerations for Surface Immobilisation of HS/Heparin Saccharides and Monitoring Their Interactions with Binding Proteins. In Chemistry and Biology of Heparin and Heparan Sulfate (pp. 345-366). Elsevier. doi:10.1016/b978-008044859-6/50013-7
Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein
Patey, S. J., Yates, E. A., & Turnbull, J. E. (2005). Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein. In S. J. Patey, E. A. yates, & J. E. Turnbull (Eds.), Biochemical Society Transactions Vol. 33 (pp. 1116-1118). X: Biochemical Society.
Novel heparan sulphate analogues:: inhibition of β-secretase cleavage of amyloid precursor protein
Patey, S. J., Yates, E. A., & Turnbull, J. E. (2005). Novel heparan sulphate analogues:: inhibition of β-secretase cleavage of amyloid precursor protein. BIOCHEMICAL SOCIETY TRANSACTIONS, 33, 1116-1118. doi:10.1042/BST0331116
Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein.
Patey, S. J., Yates, E. A., & Turnbull, J. E. (2005). Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein.. In Biochemical Society transactions Vol. 33 (pp. 1116-1118). doi:10.1042/bst20051116
Chapter 12 Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Considerations for Surface Immobilisation of HS/Heparin Saccharides and Monitoring Their Interactions with Binding Proteins
Rudd, T., Skidmore, M. A., & Yates, E. A. (2005). Chapter 12 Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Considerations for Surface Immobilisation of HS/Heparin Saccharides and Monitoring Their Interactions with Binding Proteins. In Chemistry and Biology of Heparin and Heparan Sulfate (pp. 345-366). Elsevier. doi:10.1016/b978-008044859-6/50013-7
Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Considerations for Surface Immobilisation of HS/Heparin Saccharides and Monitoring their Interactions with Binding Proteins
Rudd, T. R., Skidmore, M. A., & Yates, E. A. (2005). Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Considerations for Surface Immobilisation of HS/Heparin Saccharides and Monitoring their Interactions with Binding Proteins. In H. G. Garg, R. J. Linhardt, & C. A. Hales (Eds.), Chemistry and Biology of Heparin and Heparan sulfate (pp. 1). New York: Elsevier.
2004
Attachment of glycosaminoglycan oligosaccharides to thiol-derivatised gold surfaces
Skidmore, M. A., Patey, S. J., Thanh, N. T. K., Fernig, D. G., Turnbull, J. E., & Yates, E. A. (2004). Attachment of glycosaminoglycan oligosaccharides to thiol-derivatised gold surfaces. CHEMICAL COMMUNICATIONS, (23), 2700-2701. doi:10.1039/b411726c
Highly diverse heparan sulfate analogue libraries: a novel resource for bioactivity screening of proteins
Guimond, S. E., Patey, S. J., Yates, E. A., & Turnbull, J. E. (2004). Highly diverse heparan sulfate analogue libraries: a novel resource for bioactivity screening of proteins. International Journal of Experimental Pathology, 85(4). doi:10.1111/j.0959-9673.2004.0390w.x
Role of heparan sulfate in embryoid body formation
Drummond, K. J., Yates, E. A., Murray, P. A., & Turnbull, J. E. (2004). Role of heparan sulfate in embryoid body formation. International Journal of Experimental Pathology, 85(4). doi:10.1111/j.0959-9673.2004.0390t.x
Interactions of heparin/heparan sulfate with proteins: Appraisal of structural factors and epxerimental approaches
Powell, A. K., Yates, E. A., Fernig, D. G., & Turnbull, J. E. (2004). Interactions of heparin/heparan sulfate with proteins: Appraisal of structural factors and epxerimental approaches. GLYCOBIOLOGY, 14(4), 17R-30R. doi:10.1093/glycob/cwh051
Saccharide Libraries and Arrays
Turnbull, J., Yates, E., & Powell, A. (2004). Saccharide Libraries and Arrays.
Highly Diverse Heparan Sulfate Analogue Libraries: Providing Access to Expanded Areas of Sequence Space for Bioactivity Screening
Yates, E. A., Guimond, S. E., & Turnbull, J. E. (2004). Highly Diverse Heparan Sulfate Analogue Libraries: Providing Access to Expanded Areas of Sequence Space for Bioactivity Screening. Journal of Medicinal Chemistry, 47(1), 277-280. doi:10.1021/jm0309755
Highly diverse heparan sulfate analogue libraries: Providing access to expanded areas of sequence space for bioactivity screening
Yates, E. A., Guimond, S. E., & Turnbull, J. E. (2004). Highly diverse heparan sulfate analogue libraries: Providing access to expanded areas of sequence space for bioactivity screening. JOURNAL OF MEDICINAL CHEMISTRY, 47(1), 277-280. doi:10.1021/jm0309755
2003
Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase
Scholefield, Z., Yates, E. A., Wayne, G., Amour, A., McDowell, W., & Turnbull, J. E. (2003). Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase. JOURNAL OF CELL BIOLOGY, 163(1), 97-107. doi:10.1083/jcb.200303059
Microwave enhanced reaction of carbohydrates with amino-derivatised labels and glass surfaces
Yates, E. A., Jones, M. O., Clarke, C. E., Powell, A. K., Johnson, S. R., Porch, A., . . . Turnbull, J. E. (2003). Microwave enhanced reaction of carbohydrates with amino-derivatised labels and glass surfaces. JOURNAL OF MATERIALS CHEMISTRY, 13(9), 2061-2063. doi:10.1039/b305248f
Structural determinants of heparan sulphate modulation of GDNF signalling
Davies, J. A., Yates, E. A., & Turnbull, J. E. (2003). Structural determinants of heparan sulphate modulation of GDNF signalling. GROWTH FACTORS, 21(3-4), 109-119. doi:10.1080/08977190310001621005
Lactate carbon does not enter the sugars of lipopolysaccharide when gonococci are grown in a medium containing glucose and lactate: implications in vivo
Yates, E. A., & Smith, H. (2003). Lactate carbon does not enter the sugars of lipopolysaccharide when gonococci are grown in a medium containing glucose and lactate: implications in vivo. FEMS MICROBIOLOGY LETTERS, 218(2), 245-250. doi:10.1016/S0378-1097(02)011370
2002
<i>N</i>-acylhomoserine Lactones undergo lactonolysis in a pH-, temperature-, and acyl chain length-dependent manner during growth of <i>Yersinia pseudotuberculosis</i> and <i>Pseudomonas aeruginosa</i>
Yates, E. A., Philipp, B., Buckley, C., Atkinson, S., Chhabra, S. R., Sockett, R. E., . . . Williams, P. (2002). <i>N</i>-acylhomoserine Lactones undergo lactonolysis in a pH-, temperature-, and acyl chain length-dependent manner during growth of <i>Yersinia pseudotuberculosis</i> and <i>Pseudomonas aeruginosa</i>. INFECTION AND IMMUNITY, 70(10), 5635-5646. doi:10.1128/IAI.70.10.5635-5646.2002
Heparan sulphate binds the aspartic protease β-Secretase and regulates cleavage of APP
Scholefield, Z., Wayne, G., Amour, A., Yates, E., McDowell, B., & Turnbull, J. (2002). Heparan sulphate binds the aspartic protease β-Secretase and regulates cleavage of APP. Biochemical Society Transactions, 30(3), A69. doi:10.1042/bst030a069c
Heparan sulphate binds the aspartic protease β-secretase and regulates cleavage of APP
Scholefield, Z., Wayne, G., Amour, A., Yates, E., McDowell, B., & Turnbull, J. (2002). Heparan sulphate binds the aspartic protease β-secretase and regulates cleavage of APP. Biochemical Society Transactions, 30(3), A78. doi:10.1042/bst030a078c
Saccharide Libraries
Turnbull, J. E., Powell, A., & Yates, E. A. (2002). Saccharide Libraries. Patent, UK Pat.
Specific heparan sulfate structures involved in retinal axon targeting
Irie, A., Yates, E. A., Turnbull, J. E., & Holt, C. E. (2002). Specific heparan sulfate structures involved in retinal axon targeting. DEVELOPMENT, 129(1), 61-70. Retrieved from https://www.webofscience.com/
2001
Lactate stimulation of gonococcal metabolism in media containing glucose: Mechanism, impact on pathogenicity, and wider implications for other pathogens
Smith, H., Yates, E. A., Cole, J. A., & Parsons, N. J. (2001). Lactate stimulation of gonococcal metabolism in media containing glucose: Mechanism, impact on pathogenicity, and wider implications for other pathogens. INFECTION AND IMMUNITY, 69(11), 6565-6572. doi:10.1128/IAI.69.11.6565-6572.2001
Electrophoretic sequencing of heparin/heparan sulfate oligosaccharides using a highly sensitive fluorescent end label
Drummond, K. J., Yates, E. A., & Turnbull, J. E. (2001). Electrophoretic sequencing of heparin/heparan sulfate oligosaccharides using a highly sensitive fluorescent end label. PROTEOMICS, 1(2), 304-310. doi:3.3.CO;2-2">10.1002/1615-9861(200102)1:2<304::AID-PROT304>3.3.CO;2-2
Electrophoretic sequencing of heparin/heparan sulfate oligosaccharides using a highly sensitive fluorescent end label
Drummond, K. J., Yates, E. A., & Turnbull, J. E. (2001). Electrophoretic sequencing of heparin/heparan sulfate oligosaccharides using a highly sensitive fluorescent end label. PROTEOMICS, 1(2), 304-310. doi:3.0.co;2-b">10.1002/1615-9861(200102)1:2<304::aid-prot304>3.0.co;2-b
2000
Effect of substitution pattern on <SUP>1</SUP>H, <SUP>13</SUP>C NMR chemical shifts and <SUP>1</SUP><i>J</i><sub>CH</sub> coupling constants in heparin derivatives
Yates, E. A., Santini, F., De Cristofano, B., Payre, N., Cosentino, C., Guerrini, M., . . . Hricovini, M. (2000). Effect of substitution pattern on <SUP>1</SUP>H, <SUP>13</SUP>C NMR chemical shifts and <SUP>1</SUP><i>J</i><sub>CH</sub> coupling constants in heparin derivatives. CARBOHYDRATE RESEARCH, 329(1), 239-247. doi:10.1016/S0008-6215(00)00144-0
In a medium containing glucose, lactate carbon is incorporated by gonococci predominantly into fatty acids and glucose carbon incorporation is increased
Yates, E. A., Gao, L., Woodcock, N., Parsons, N., Cole, J., & Smith, H. (2000). In a medium containing glucose, lactate carbon is incorporated by gonococci predominantly into fatty acids and glucose carbon incorporation is increased. Int.J.Med.Microbiol.,, 290, 627-639.
In a medium containing glucose, lactate carbon is incorporated by gonococci predominantly into fatty acids and glucose carbon incorporation is increased: implications regarding lactate stimulation of metabolism
Yates, E., Gao, L. H., Woodcock, N., Parsons, N., Cole, J., & Smith, H. (2000). In a medium containing glucose, lactate carbon is incorporated by gonococci predominantly into fatty acids and glucose carbon incorporation is increased: implications regarding lactate stimulation of metabolism. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 290(7), 627-639. Retrieved from https://www.webofscience.com/
1999
Introduction of a nitrogen heterocycle into sulphated chitosan oligomers
Santini, F., Crini, G., Cosentino, C., Sturiale, L., & Yates, E. A. (1999). Introduction of a nitrogen heterocycle into sulphated chitosan oligomers. JOURNAL OF CARBOHYDRATE CHEMISTRY, 18(1), 105-111. doi:10.1080/07328309908543983
1997
Modifications under basic conditions of the minor sequences of heparin containing 2,3 or 2,3,6 sulfated D-glucosamine residues
Santini, F., Bisio, A., Guerrini, M., & Yates, E. A. (1997). Modifications under basic conditions of the minor sequences of heparin containing 2,3 or 2,3,6 sulfated D-glucosamine residues. CARBOHYDRATE RESEARCH, 302(1-2), 103-108. doi:10.1016/S0008-6215(97)00111-0
Evidence for a heparin derivative containing an N-sulfated aziridine ring that retains high anti-factor Xa activity
Yates, E. A., Santini, F., Bisio, A., & Cosentino, C. (1997). Evidence for a heparin derivative containing an N-sulfated aziridine ring that retains high anti-factor Xa activity. CARBOHYDRATE RESEARCH, 298(4), 335-340. doi:10.1016/S0008-6215(96)00327-8
A heparin derivative containing an unusual N-sulphated aziridine group retains high anti factor-Xa activity
Yates, E. A., Santini, F., Bisio, A., & Cosentino, C. (1997). A heparin derivative containing an unusual N-sulphated aziridine group retains high anti factor-Xa activity. Carbohydr.Res.,, 335-340.
1996
1H and 13C NMR spectral assignments of the major sequences of twelve systematically modified heparin derivatives.
Yates, E. A., Santini, F., Guerrini, M., Naggi, A., Torri, G., & Casu, B. (1996). 1H and 13C NMR spectral assignments of the major sequences of twelve systematically modified heparin derivatives.. Carbohydrate research, 294, 15-27. doi:10.1016/s0008-6215(96)90611-4
1-H and 13-C NMR spectral assignments of the major sequences of twelve systematically modified heparin derivatives
Yates, E. A., Santini, F., Guerrini, M., Naggi, A., Torri, G., & Casu, B. (1996). 1-H and 13-C NMR spectral assignments of the major sequences of twelve systematically modified heparin derivatives. Carbohydr. Res.,, 294, 15-27.
Characterization of carbohydrate structural features recognized by anti-arabinogalactan-protein monoclonal antibodies
Yates, E. A., Valdor, J. F., Haslam, S. M., Morris, H. R., Dell, A., Mackie, W., & Knox, J. P. (1996). Characterization of carbohydrate structural features recognized by anti-arabinogalactan-protein monoclonal antibodies. GLYCOBIOLOGY, 6(2), 131-139. doi:10.1093/glycob/6.2.131
H-1 and C-13 NMR spectral assignments of the major sequences of twelve systematically modified heparin derivatives
Yates, E. A., Santini, F., Guerrini, M., Naggi, A., Torri, G., & Casu, B. (1996). H-1 and C-13 NMR spectral assignments of the major sequences of twelve systematically modified heparin derivatives. CARBOHYDRATE RESEARCH, 294, 15-27. Retrieved from https://www.webofscience.com/
Immunochemical comparison of membrane-associated and secreted arabinogalactan-proteins in rice and carrot
Smallwood, M., Yates, E. A., Willats, W. G. T., Martin, H., & Knox, J. P. (1996). Immunochemical comparison of membrane-associated and secreted arabinogalactan-proteins in rice and carrot. PLANTA, 198(3), 452-459. doi:10.1007/BF00620063
1995
ChemInform Abstract: Structural Studies of O‐Sulfated D‐Glucosamines. The Crystal and Molecular Structures of 2‐Amino‐2‐deoxy‐α/β‐D‐glucopyranose 3‐Sulfate (Free Acid) and 2‐Amino‐2‐deoxy‐β‐D‐glucopyranose 6‐ Sulfate (Free Base).
MACKIE, W., YATES, E. A., & LAMBA, D. (1995). ChemInform Abstract: Structural Studies of O‐Sulfated D‐Glucosamines. The Crystal and Molecular Structures of 2‐Amino‐2‐deoxy‐α/β‐D‐glucopyranose 3‐Sulfate (Free Acid) and 2‐Amino‐2‐deoxy‐β‐D‐glucopyranose 6‐ Sulfate (Free Base).. ChemInform, 26(21). doi:10.1002/chin.199521251
STRUCTURAL STUDIES OF O-SULFATED D-GLUCOSAMINES - THE CRYSTAL AND MOLECULAR-STRUCTURES OF 2-AMINO-2-DEOXY-ALPHA/BETA-D-GLUCOPYRANOSE 3-SULFATE (FREE ACID) AND 2-AMINO-2-DEOXY-BETA-D-GLUCOPYRANOSE 6-SULFATE (FREE-BASE)
MACKIE, W., YATES, E. A., & LAMBA, D. (1995). STRUCTURAL STUDIES OF O-SULFATED D-GLUCOSAMINES - THE CRYSTAL AND MOLECULAR-STRUCTURES OF 2-AMINO-2-DEOXY-ALPHA/BETA-D-GLUCOPYRANOSE 3-SULFATE (FREE ACID) AND 2-AMINO-2-DEOXY-BETA-D-GLUCOPYRANOSE 6-SULFATE (FREE-BASE). CARBOHYDRATE RESEARCH, 266(1), 65-74. doi:10.1016/0008-6215(94)00248-E
THE CRYSTAL AND MOLECULAR-STRUCTURE OF 2-SULFAMINO-2-DEOXY-ALPHA-D-GLUCOPYRANOSE SODIUM SALT-CENTER-DOT-2H(2)O (GLUCOSAMINE 2-SULFATE)
YATES, E. A., MACKIE, W., & LAMBA, D. (1995). THE CRYSTAL AND MOLECULAR-STRUCTURE OF 2-SULFAMINO-2-DEOXY-ALPHA-D-GLUCOPYRANOSE SODIUM SALT-CENTER-DOT-2H(2)O (GLUCOSAMINE 2-SULFATE). INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 17(3-4), 219-226. doi:10.1016/0141-8130(95)92689-N
The crystal and molecular structure of 2-deoxy-2-amino-alpha D-glucopyranose (sodium sulphate) 2H2O
Yates, E. A., Lamba, D., & Mackie, W. (1995). The crystal and molecular structure of 2-deoxy-2-amino-alpha D-glucopyranose (sodium sulphate) 2H2O. Int. J. Biol. Macromol.,, 17, 219-226.
The crystal and molecular structures of 2-amino- alpha/beta D-glucopyranose 3-sulphate free acid and 2-amino-2-deoxy-beta-D-glucopyranose 6-sulphate free base
Mackie, W., Yates, E. A., & Lamba, D. (1995). The crystal and molecular structures of 2-amino- alpha/beta D-glucopyranose 3-sulphate free acid and 2-amino-2-deoxy-beta-D-glucopyranose 6-sulphate free base. Carbohydrate Research, 266, 65-74.
1994
INVESTIGATIONS INTO THE OCCURRENCE OF PLANT-CELL SURFACE EPITOPES IN EXUDATE GUMS
YATES, E. A., & KNOX, J. P. (1994). INVESTIGATIONS INTO THE OCCURRENCE OF PLANT-CELL SURFACE EPITOPES IN EXUDATE GUMS. CARBOHYDRATE POLYMERS, 24(4), 281-286. doi:10.1016/0144-8617(94)90072-8
1993
SYNTHESIS AND X-RAY CRYSTALLOGRAPHIC STRUCTURE DETERMINATION OF METHYL ALPHA-D-GALACTOPYRANOSIDE 2,6-BIS(SODIUM SULFATE).2H2O
LAMBA, D., MACKIE, W., RASHID, A., SHELDRICK, B., & YATES, E. A. (1993). SYNTHESIS AND X-RAY CRYSTALLOGRAPHIC STRUCTURE DETERMINATION OF METHYL ALPHA-D-GALACTOPYRANOSIDE 2,6-BIS(SODIUM SULFATE).2H2O. CARBOHYDRATE RESEARCH, 241, 89-98. doi:10.1016/0008-6215(93)80098-Y
Synthetic and structural studies of sulphated carbohydrates
Yates, E. A. (1993). Synthetic and structural studies of sulphated carbohydrates. (PhD Thesis, The University of Leeds).