Publications
2024
Improved Detection of Drug-Induced Liver Injury by Integrating Predicted <i>In Vivo</i> and <i>In Vitro</i> Data.
Seal, S., Williams, D., Hosseini-Gerami, L., Mahale, M., Carpenter, A. E., Spjuth, O., & Bender, A. (2024). Improved Detection of Drug-Induced Liver Injury by Integrating Predicted <i>In Vivo</i> and <i>In Vitro</i> Data.. Chemical research in toxicology, 37(8), 1290-1305. doi:10.1021/acs.chemrestox.4c00015
Leaf only SAM: A segment anything pipeline for zero-shot automated leaf segmentation
Williams, D., Macfarlane, F., & Britten, A. (2024). Leaf only SAM: A segment anything pipeline for zero-shot automated leaf segmentation. Smart Agricultural Technology, 8, 100515. doi:10.1016/j.atech.2024.100515
Improved Detection of Drug-Induced Liver Injury by Integrating Predicted<i>in vivo</i>and<i>in vitro</i>Data
2023
Raspberry plant stress detection using hyperspectral imaging.
Williams, D., Karley, A., Britten, A., McCallum, S., & Graham, J. (2023). Raspberry plant stress detection using hyperspectral imaging.. Plant direct, 7(3), e490. doi:10.1002/pld3.490
2022
The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds
Brecklinghaus, T., Albrecht, W., Kappenberg, F., Duda, J., Vartak, N., Edlund, K., . . . Hengstler, J. G. (2022). The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds. Chemico-Biological Interactions, 351, 109728. doi:10.1016/j.cbi.2021.109728
2021
Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress.
O'Brien, K. A., McNally, B. D., Sowton, A. P., Murgia, A., Armitage, J., Thomas, L. W., . . . Murray, A. J. (2021). Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress.. BMC biology, 19(1), 265. doi:10.1186/s12915-021-01192-0
Quantifying sources of uncertainty in drug discovery predictions with probabilistic models
Lazic, S. E., & Williams, D. P. (2021). Quantifying sources of uncertainty in drug discovery predictions with probabilistic models. Artificial Intelligence in the Life Sciences, 1, 100004. doi:10.1016/j.ailsci.2021.100004
In silico approaches in organ toxicity hazard assessment: Current status and future needs in predicting liver toxicity
Bassan, A., Alves, V. M., Amberg, A., Anger, L. T., Auerbach, S., Beilke, L., . . . Myatt, G. J. (2021). In silico approaches in organ toxicity hazard assessment: Current status and future needs in predicting liver toxicity. Computational Toxicology, 20, 100187. doi:10.1016/j.comtox.2021.100187
Seeing the wood for the trees: hyperspectral imaging for high throughput QTL detection in raspberry, a perennial crop species
Williams, D., Hackett, C. A., Karley, A., McCallum, S., Smith, K., Britten, A., & Graham, J. (2021). Seeing the wood for the trees: hyperspectral imaging for high throughput QTL detection in raspberry, a perennial crop species. Fruit Research, 1(1), 1-11. doi:10.48130/frures-2021-0007
2020
Retraction Note: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity.
Antoine, D. J., Williams, D. P., Kipar, A., Laverty, H., & Park, B. K. (2020). Retraction Note: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity.. Molecular medicine (Cambridge, Mass.), 26(1), 130. doi:10.1186/s10020-020-00262-3
HepG2 (C3A) spheroids show higher sensitivity compared to HepaRG spheroids for drug-induced liver injury (DILI).
Basharat, A., Rollison, H. E., Williams, D. P., & Ivanov, D. P. (2020). HepG2 (C3A) spheroids show higher sensitivity compared to HepaRG spheroids for drug-induced liver injury (DILI).. Toxicology and applied pharmacology, 408, 115279. doi:10.1016/j.taap.2020.115279
Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells
Matthews, O., Morrison, E. E., Tranter, J. D., Lewis, P. S., Toor, I. S., Srivastava, A., . . . Dear, J. W. (2020). Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells. EBIOMEDICINE, 62. doi:10.1016/j.ebiom.2020.103092
A Bayesian neural network for toxicity prediction
Semenova, E., Williams, D. P., Afzal, A. M., & Lazic, S. E. (2020). A Bayesian neural network for toxicity prediction. Computational Toxicology, 16, 100133. doi:10.1016/j.comtox.2020.100133
Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity (Retraction of Vol 56, Pg 1070, 2012)
Antoine, D. J., Jenkins, R. E., Dear, J. W., Williams, D. P., McGill, M. R., Sharpe, M. R., . . . Park, B. K. (2020). Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity (Retraction of Vol 56, Pg 1070, 2012). JOURNAL OF HEPATOLOGY, 73(5), 1297. doi:10.1016/j.jhep.2020.08.022
The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine.
Jolly, C. E., Douglas, O., Kamalian, L., Jenkins, R. E., Beckett, A. J., Penman, S. L., . . . Chadwick, A. E. (2020). The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine.. Toxicology and applied pharmacology, 403, 115163. doi:10.1016/j.taap.2020.115163
Morphological and Mechanistic Aspects of Thiourea-Induced Acute Lung Injury and Tolerance in the Rat
Pellegrini, G., Williams, D. P., Amadio, D., Park, B. K., & Kipar, A. (2020). Morphological and Mechanistic Aspects of Thiourea-Induced Acute Lung Injury and Tolerance in the Rat. Toxicologic Pathology, 48(6), 725-737. doi:10.1177/0192623320941465
A Bayesian neural network for toxicity prediction
Determining organ weight toxicity with Bayesian causal models: Improving on the analysis of relative organ weights.
Lazic, S. E., Semenova, E., & Williams, D. P. (2020). Determining organ weight toxicity with Bayesian causal models: Improving on the analysis of relative organ weights.. Scientific reports, 10(1), 6625. doi:10.1038/s41598-020-63465-y
Development and use of genetic tools in <i>Rubus</i> and <i>Ribes</i> breeding at James Hutton Institute/Limited
Jarret, D., Jennings, N., Williams, D., & Graham, J. (2020). Development and use of genetic tools in <i>Rubus</i> and <i>Ribes</i> breeding at James Hutton Institute/Limited. In Acta Horticulturae (pp. 1-10). International Society for Horticultural Science (ISHS). doi:10.17660/actahortic.2020.1277.1
Functionality of primary hepatic non-parenchymal cells in a 3D spheroid model and contribution to acetaminophen hepatotoxicity.
Bell, C. C., Chouhan, B., Andersson, L. C., Andersson, H., Dear, J. W., Williams, D. P., & Söderberg, M. (2020). Functionality of primary hepatic non-parenchymal cells in a 3D spheroid model and contribution to acetaminophen hepatotoxicity.. Archives of toxicology, 94(4), 1251-1263. doi:10.1007/s00204-020-02682-w
Multiscale modelling of drug transport and metabolism in liver spheroids
Leedale, J. A., Kyffin, J., Harding, A., Colley, H., Murdoch, C., Sharma, P., . . . Bearon, R. (2020). Multiscale modelling of drug transport and metabolism in liver spheroids. Interface Focus, 10(2). doi:10.1098/rsfs.2019.0041
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
Weaver, R. J., Blomme, E. A., Chadwick, A. E., Copple, I. M., Gerets, H. H. J., Goldring, C. E., . . . Park, B. K. (2020). Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models. NATURE REVIEWS DRUG DISCOVERY, 19(2), 131-148. doi:10.1038/s41573-019-0048-x
Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatoxicity (Expression of Concern of Vol 16, Pg 479, 2010)
Antoine, D. J., Williams, D. P., Kipar, A., Laverty, H., & Park, B. K. (2020). Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatoxicity (Expression of Concern of Vol 16, Pg 479, 2010). MOLECULAR MEDICINE, 26(1). doi:10.1186/s10020-020-0140-z
Predicting Drug-Induced Liver Injury with Bayesian Machine Learning
Williams, D. P., Lazic, S. E., Foster, A. J., Semenova, E., & Morgan, P. (2020). Predicting Drug-Induced Liver Injury with Bayesian Machine Learning. CHEMICAL RESEARCH IN TOXICOLOGY, 33(1), 239-248. doi:10.1021/acs.chemrestox.9b00264
2019
Reproducing human and cross-species drug toxicities using a Liver-Chip.
Jang, K. -J., Otieno, M. A., Ronxhi, J., Lim, H. -K., Ewart, L., Kodella, K. R., . . . Hamilton, G. A. (2019). Reproducing human and cross-species drug toxicities using a Liver-Chip.. Science translational medicine, 11(517), eaax5516. doi:10.1126/scitranslmed.aax5516
In silico-guided optimisation of oxygen gradients in hepatic spheroids
Leedale, J., Colley, H. E., Gaskell, H., Williams, D. P., Bearon, R. N., Chadwick, A. E., . . . Webb, S. D. (2019). In silico-guided optimisation of oxygen gradients in hepatic spheroids. Computational Toxicology, 12, 100093. doi:10.1016/j.comtox.2019.100093
Mathematical modelling of a liver hollow fibre bioreactor
Sorrell, I., Shipley, R. J., Regan, S., Gardner, I., Storm, M. P., Ellis, M., . . . Webb, S. (2019). Mathematical modelling of a liver hollow fibre bioreactor. JOURNAL OF THEORETICAL BIOLOGY, 475, 25-33. doi:10.1016/j.jtbi.2019.05.008
On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships.
McAleer, C. W., Pointon, A., Long, C. J., Brighton, R. L., Wilkin, B. D., Bridges, L. R., . . . Ewart, L. (2019). On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships.. Scientific reports, 9(1), 9619. doi:10.1038/s41598-019-45656-4
Acute Metabolic Switch Assay Using Glucose/Galactose Medium in HepaRG Cells to Detect Mitochondrial Toxicity.
Kamalian, L., Douglas, O., Jolly, C. E., Snoeys, J., Simic, D., Monshouwer, M., . . . Chadwick, A. E. (2019). Acute Metabolic Switch Assay Using Glucose/Galactose Medium in HepaRG Cells to Detect Mitochondrial Toxicity.. Current protocols in toxicology, 80(01). doi:10.1002/cptx.76
Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid
Foster, A. J., Chouhan, B., Regan, S. L., Rollison, H., Amberntsson, S., Andersson, L. C., . . . Morgan, P. (2019). Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid. ARCHIVES OF TOXICOLOGY, 93(4), 1021-1037. doi:10.1007/s00204-019-02427-4
Introducing an automated high content confocal imaging approach for Organs-on-Chips.
Peel, S., Corrigan, A. M., Ehrhardt, B., Jang, K. -J., Caetano-Pinto, P., Boeckeler, M., . . . Ewart, L. (2019). Introducing an automated high content confocal imaging approach for Organs-on-Chips.. Lab on a chip, 19(3), 410-421. doi:10.1039/c8lc00829a
2018
The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity
Kamalian, L., Douglas, O., Jolly, C. E., Snoeys, J., Simic, D., Monshouwer, M., . . . Chadwick, A. E. (2018). The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity. TOXICOLOGY IN VITRO, 53, 136-147. doi:10.1016/j.tiv.2018.08.001
Application of hepatocyte-like cells to enhance hepatic safety risk assessment in drug discovery
Williams, D. P. (2018). Application of hepatocyte-like cells to enhance hepatic safety risk assessment in drug discovery. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 373(1750). doi:10.1098/rstb.2017.0228
A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function.
Karageorgis, A., Lenhard, S. C., Yerby, B., Forsgren, M. F., Liachenko, S., Johansson, E., . . . Hockings, P. D. (2018). A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function.. PloS one, 13(5), e0197213. doi:10.1371/journal.pone.0197213
Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study
Bell, C. C., Dankers, A. C. A., Lauschke, V. M., Sison-Young, R., Jenkins, R., Rowe, C., . . . Ingelman-Sundberg, M. (2018). Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study. TOXICOLOGICAL SCIENCES, 162(2), 655-666. doi:10.1093/toxsci/kfx289
Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery.
Ewart, L., Dehne, E. -M., Fabre, K., Gibbs, S., Hickman, J., Hornberg, E., . . . Newham, P. (2018). Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery. (Vol. 58). doi:10.1146/annurev-pharmtox-010617-052722
2017
A method for automatic segmentation and splitting of hyperspectral images of raspberry plants collected in field conditions.
Williams, D., Britten, A., McCallum, S., Jones, H., Aitkenhead, M., Karley, A., . . . Graham, J. (2017). A method for automatic segmentation and splitting of hyperspectral images of raspberry plants collected in field conditions.. Plant methods, 13, 74. doi:10.1186/s13007-017-0226-y
Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury
Proctor, W. R., Foster, A. J., Vogt, J., Summers, C., Middleton, B., Pilling, M. A., . . . Williams, D. (2017). Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury. ARCHIVES OF TOXICOLOGY, 91(8), 2849-2863. doi:10.1007/s00204-017-2002-1
2016
Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats
Richert, L., Baze, A., Parmentier, C., Gerets, H. H. J., Sison-Young, R., Dorau, M., . . . Williams, D. P. (2016). Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats. TOXICOLOGY LETTERS, 258, 207-215. doi:10.1016/j.toxlet.2016.06.1127
Characterization of a Functional C3A Liver Spheroid Model
Gaskell, H., Sharma, P., Colley, H. E., Murdoch, C., Williams, D. P., & Webb, S. D. (2016). Characterization of a Functional C3A Liver Spheroid Model. Toxicological Research, 5(04), 1053-1065. doi:10.1039/C6TX00101G.
Nondestructive analysis of automotive paints with spectral domain optical coherence tomography
Dong, Y., Lawman, S., Zheng, Y., Williams, D., Zhang, J., & Shen, Y. -C. (2016). Nondestructive analysis of automotive paints with spectral domain optical coherence tomography. APPLIED OPTICS, 55(13), 3695-3700. doi:10.1364/AO.55.003695
Reactive Metabolites: Current and Emerging Risk and Hazard Assessments
Thompson, R. A., Isin, E. M., Ogese, M. O., Mettetal, J. T., & Williams, D. P. (2016). Reactive Metabolites: Current and Emerging Risk and Hazard Assessments. CHEMICAL RESEARCH IN TOXICOLOGY, 29(4), 505-533. doi:10.1021/acs.chemrestox.5b00410
Reconstruction of 3D Surface Maps from Anterior Segment Optical Coherence Tomography Images Using Graph Theory and Genetic Algorithms
Williams, D., Zheng, Y., Davey, P. G., Bao, F., Shen, M., & Elsheikh, A. (2016). Reconstruction of 3D Surface Maps from Anterior Segment Optical Coherence Tomography Images Using Graph Theory and Genetic Algorithms. Biomedical Signal Processing and Control, 25, 91-98. doi:10.1016/j.bspc.2015.11.004
2015
Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity
Reddyhoff, D., Ward, J., Williams, D., Regan, S., & Webb, S. (2015). Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity. JOURNAL OF THEORETICAL BIOLOGY, 386, 132-146. doi:10.1016/j.jtbi.2015.08.021
Fast segmentation of anterior segment optical coherence tomography images using graph cut
Williams, D., Zheng, Y., Bao, F., & Elsheikh, A. (2015). Fast segmentation of anterior segment optical coherence tomography images using graph cut. EYE AND VISION, 2. doi:10.1186/s40662-015-0011-9
Quantification of Low-Level Drug Effects Using Real-Time, <i>in vitro</i> Measurement of Oxygen Consumption Rate
Neal, A., Rountree, A. M., Philips, C. W., Kavanagh, T. J., Williams, D. P., Newham, P., . . . Sweet, I. R. (2015). Quantification of Low-Level Drug Effects Using Real-Time, <i>in vitro</i> Measurement of Oxygen Consumption Rate. TOXICOLOGICAL SCIENCES, 148(2), 594-602. doi:10.1093/toxsci/kfv208
Exploring the translational disconnect between the murine and human inflammatory response: analysis of LPS dose-response relationship in murine versus human cell lines and implications for translation into murine models of sepsis.
McCarron, E. P., Williams, D. P., Antoine, D. J., Kipar, A., Lemm, J., Stehr, S., & Welters, I. D. (2015). Exploring the translational disconnect between the murine and human inflammatory response: analysis of LPS dose-response relationship in murine versus human cell lines and implications for translation into murine models of sepsis.. Journal of Inflammation Research, 8, 201-209. doi:10.2147/JIR.S89097
Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies
Heslop, J. A., Hammond, T. G., Santeramo, I., Piella, A. T., Hopp, I., Zhou, J., . . . Park, B. K. (2015). Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies. STEM CELLS TRANSLATIONAL MEDICINE, 4(4), 389-400. doi:10.5966/sctm.2014-0110
2014
Chronic intravenous infusion as a model to investigate mechanisms of toxicity
Norton, A. M., Clarke, J. I., McCarthy, A., Williams, D. P., & Park, B. K. (2014). Chronic intravenous infusion as a model to investigate mechanisms of toxicity. In TOXICOLOGY LETTERS Vol. 229 (pp. S46). doi:10.1016/j.toxlet.2014.06.200
Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist
Thaventhiran, T., Alhumeed, N., Yeang, H. X. A., Sethu, S., Downey, J. S., Alghanem, A. F., . . . Sathish, J. G. (2014). Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist. MABS, 6(5), 1290-1299. doi:10.4161/mabs.29758
Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers (vol 314, pg 262, 2013)
Pellegrini, G., Lewis, P. J. S., Palmer, L., Hetzel, U., Goldring, C. E., Park, B. K., . . . Williams, D. P. (2014). Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers (vol 314, pg 262, 2013). TOXICOLOGY, 318, 69-71. doi:10.1016/j.tox.2014.02.005
Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients
Hammond, T. G., Meng, X., Jenkins, R. E., Maggs, J. L., Castelazo, A. S., Regan, S. L., . . . Williams, D. P. (2014). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 350(2), 387-402. doi:10.1124/jpet.114.215079
Modeling hepatic drug metabolism and toxicity: where are we heading?
Williams, D. P. (2014). Modeling hepatic drug metabolism and toxicity: where are we heading?. FUTURE MEDICINAL CHEMISTRY, 6(7), 725-727. doi:10.4155/FMC.14.31
Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and its inhibition by nitisinone
Preston, A. J., Keenan, C. M., Sutherland, H., Wilson, P. J., Wlodarski, B., Taylor, A. M., . . . Jarvis, J. C. (2014). Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and its inhibition by nitisinone. ANNALS OF THE RHEUMATIC DISEASES, 73(1), 284-289. doi:10.1136/annrheumdis-2012-202878
2013
Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers
Pellegrini, G., Lewis, P. J. S., Palmer, L., Hetzel, U., Goldring, C. E., Park, B. K., . . . Williams, D. P. (2013). Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers. TOXICOLOGY, 314(2-3), 262-266. doi:10.1016/j.tox.2013.06.003
Safety pharmacology - Current and emerging concepts
Hamdam, J., Sethu, S., Smith, T., Alfirevic, A., Alhaidari, M., Atkinson, J., . . . Goldring, C. (2013). Safety pharmacology - Current and emerging concepts. TOXICOLOGY AND APPLIED PHARMACOLOGY, 273(2), 229-241. doi:10.1016/j.taap.2013.04.039
The Generation, Detection, and Effects of Reactive Drug Metabolites
Stachulski, A. V., Baillie, T. A., Park, B. K., Obach, R. S., Dalvie, D. K., Williams, D. P., . . . Lennard, M. S. (2013). The Generation, Detection, and Effects of Reactive Drug Metabolites. MEDICINAL RESEARCH REVIEWS, 33(5), 985-1080. doi:10.1002/med.21273
Automatic segmentation of anterior segment optical coherence tomography images
Williams, D., Zheng, Y., Bao, F., & Elsheikh, A. (2013). Automatic segmentation of anterior segment optical coherence tomography images. In JOURNAL OF BIOMEDICAL OPTICS Vol. 18. doi:10.1117/1.JBO.18.5.056003
Novel <i>in vitro</i> and mathematical models for the prediction of chemical toxicity
Williams, D. P., Shipley, R., Ellis, M. J., Webb, S., Ward, J., Gardner, I., & Creton, S. (2013). Novel <i>in vitro</i> and mathematical models for the prediction of chemical toxicity. TOXICOLOGY RESEARCH, 2(1), 40-59. doi:10.1039/c2tx20031g
2012
Haloarene Derivatives of Carbamazepine with Reduced Bioactivation Liabilities: 2-Monohalo and 2,8-Dihalo Derivatives
Elliott, E. -C., Regan, S. L., Maggs, J. L., Bowkett, E. R., Parry, L. J., Williams, D. P., . . . Stachulski, A. V. (2012). Haloarene Derivatives of Carbamazepine with Reduced Bioactivation Liabilities: 2-Monohalo and 2,8-Dihalo Derivatives. JOURNAL OF MEDICINAL CHEMISTRY, 55(22), 9773-9784. doi:10.1021/jm301013n
Drug Bioactivation and Oxidative Stress
Webb, H. M., Regan, S., Antoine, D. J., Lane, N., Walsh, R. J., Srivastava, A., . . . Park, B. K. (n.d.). Drug Bioactivation and Oxidative Stress. In Unknown Book (pp. 1-44). Wiley. doi:10.1002/9780470921920.edm053
Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity (Publication with Expression of Concern. See vol. 73, pg. 1297, 2020) (Publication with Expression of Concern. See vol. 69, pg. 1402, 2018) (Retracted article. See vol. 73, pg. 1297, 2020)
Antoine, D. J., Jenkins, R. E., Dear, J. W., Williams, D. P., McGill, M. R., Sharpe, M. R., . . . Park, B. K. (2012). Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity (Publication with Expression of Concern. See vol. 73, pg. 1297, 2020) (Publication with Expression of Concern. See vol. 69, pg. 1402, 2018) (Retracted article. See vol. 73, pg. 1297, 2020). JOURNAL OF HEPATOLOGY, 56(5), 1070-1079. doi:10.1016/j.jhep.2011.12.019
The Generation, Detection, and Effects of Reactive Drug Metabolites.
Stachulski, A. V., Baillie, T. A., Kevin Park, B., Scott Obach, R., Dalvie, D. K., Williams, D. P., . . . Lennard, M. S. (2012). The Generation, Detection, and Effects of Reactive Drug Metabolites.. Medicinal Research Reviews. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/23090860
2011
The genotoxic potential of methapyrilene using the alkaline Comet assay <i>in</i> <i>vitro</i> and <i>in vivo</i>
Priestley, C. C., Regan, S., Park, B. K., & Williams, D. P. (2011). The genotoxic potential of methapyrilene using the alkaline Comet assay <i>in</i> <i>vitro</i> and <i>in vivo</i>. TOXICOLOGY, 290(2-3), 249-257. doi:10.1016/j.tox.2011.10.002
Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity
Park, B. K., Laverty, H., Srivastava, A., Antoine, D. J., Naisbitt, D., & Williams, D. P. (2011). Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity. CHEMICO-BIOLOGICAL INTERACTIONS, 192(1-2), 30-36. doi:10.1016/j.cbi.2010.09.011
Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury
Williams, C. D., Antoine, D. J., Shaw, P. J., Benson, C., Farhood, A., Williams, D. P., . . . Jaeschke, H. (2011). Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury. TOXICOLOGY AND APPLIED PHARMACOLOGY, 252(3), 289-297. doi:10.1016/j.taap.2011.03.001
Managing the challenge of chemically reactive metabolites in drug development
Park, B. K., Boobis, A., Clarke, S., Goldring, C. E. P., Jones, D., Kenna, J. G., . . . Baillie, T. A. (2011). Managing the challenge of chemically reactive metabolites in drug development. NATURE REVIEWS DRUG DISCOVERY, 10(4), 292-306. doi:10.1038/nrd3408
Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity.
Park, B. K., Laverty, H., Srivastava, A., Antoine, D. J., Naisbitt, D., & Williams, D. P. (2011). Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity.. Chem Biol Interact, 192(1-2), 30-36.
Managing the challenge of chemically reactive metabolites in drug development.
Park, B. K., Boobis, A., Clarke, S., Goldring, C., Jones, D., Kenna, J. G., . . . Baillie, T. A. (2011). Managing the challenge of chemically reactive metabolites in drug development.. Nature Reviews Drug Discovery, 10(4), 292-306.
The genotoxic potential of methapyrilene using the alkaline Comet assay in vitro and in vivo.
Priestley, C. C., Regan, S., Park, K. B., & Williams, D. P. (2011). The genotoxic potential of methapyrilene using the alkaline Comet assay in vitro and in vivo.. Toxicology, E-pub.
2010
Investigation into the metabolism and toxicity of nefazodone and buspirone
Lane, N., Maggs, J., Park, K., & Williams, D. (2010). Investigation into the metabolism and toxicity of nefazodone and buspirone. In TOXICOLOGY Vol. 278 (pp. 365-366). doi:10.1016/j.tox.2010.08.121
Pharmacokinetic investigation into the mechanism of toxicity of Furosemide and its thiophene analogue
Webb, H., Duckworth, J., Turnpenny, P., Gardner, I., Smith, D., Parkl, K., & Williams, D. (2010). Pharmacokinetic investigation into the mechanism of toxicity of Furosemide and its thiophene analogue. In TOXICOLOGY Vol. 278 (pp. 366). doi:10.1016/j.tox.2010.08.122
The metabolism of carbamazepine in fresh rodent hepatocyte suspensions: The effect of bromine substitution on metabolism
Regan, S., Elliot, E., Maggs, J., Stachulski, A., Williams, D., & Park, K. (2010). The metabolism of carbamazepine in fresh rodent hepatocyte suspensions: The effect of bromine substitution on metabolism. In TOXICOLOGY Vol. 278 (pp. 358). doi:10.1016/j.tox.2010.08.109
Toxicological Consequences of Drug-Drug Interactions
Walsh, R. J., Srivastava, A., Antoine, D. J., Williams, D. P., & Park, B. K. (2010). Toxicological Consequences of Drug-Drug Interactions. In Unknown Book (pp. 651-664). doi:10.1007/978-1-4419-0840-7_25
Acyl Glucuronides: The Good, The Bad and The Ugly
Regan, S. L., Maggs, J. L., Hammond, T. G., Lambert, C., Williams, D. P., & Park, B. K. (2010). Acyl Glucuronides: The Good, The Bad and The Ugly. BIOPHARMACEUTICS & DRUG DISPOSITION, 31(7), 367-395. doi:10.1002/bdd.720
The potential of cytokines as safety biomarkers for drug-induced liver injury
Laverty, H. G., Antoine, D. J., Benson, C., Chaponda, M., Williams, D., & Park, B. K. (2010). The potential of cytokines as safety biomarkers for drug-induced liver injury. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 66(10), 961-976. doi:10.1007/s00228-010-0862-x
Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries (vol 38, pg 122, 2010)
Srivastava, A., Lian, L. -Y., Maggs, J. L., Chaponda, M., Pirmohamed, M., Williams, D. P., & Park, B. K. (2010). Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries (vol 38, pg 122, 2010). DRUG METABOLISM AND DISPOSITION, 38(7), 1259. doi:10.1124/dmd.38.7.1259
Integrated systems for quantifying metabolite biomarkers of hepatic bioactivation in patients
Williams, D. (2010). Integrated systems for quantifying metabolite biomarkers of hepatic bioactivation in patients. BIOANALYSIS, 2(4), 693-697. doi:10.4155/BIO.10.23
Role of reactive metabolites in drug-induced hepatotoxicity.
Srivastava, A., Maggs, J. L., Antoine, D. J., Williams, D. P., Smith, D. A., & Park, B. K. (2010). Role of reactive metabolites in drug-induced hepatotoxicity.. Handbook of experimental pharmacology, (196), 165-194. doi:10.1007/978-3-642-00663-0_7
Acyl glucuronides: the good, the bad and the ugly
Regan, S. L., Maggs, J. L., Hammond, T. G., Lambert, C., Williams, D. P., & Park, B. K. (2010). Acyl glucuronides: the good, the bad and the ugly. Biopharmaceutics and Drug Disposition, 31(7), 367-395.
Diet Restriction Inhibits Apoptosis and HMGB1 Oxidation and Promotes Inflammatory Cell Recruitment during Acetaminophen Hepatotoxicity (Publication with Expression of Concern. See vol. 26, 2020) (Retracted article. See vol. 26, 2020)
Antoine, D. J., Williams, D. P., Kipar, A., Laverty, H., & Park, B. K. (2010). Diet Restriction Inhibits Apoptosis and HMGB1 Oxidation and Promotes Inflammatory Cell Recruitment during Acetaminophen Hepatotoxicity (Publication with Expression of Concern. See vol. 26, 2020) (Retracted article. See vol. 26, 2020). MOLECULAR MEDICINE, 16(11-12), 479-490. doi:10.2119/molmed.2010.00126
Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells
Martin, P., Riley, R., Thompson, P., Williams, D., Back, D., & Owen, A. (2010). Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells. ACTA PHARMACOLOGICA SINICA, 31(1), 51-65. doi:10.1038/aps.2009.187
Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in <i>p</i>-Phenylenediamine Allergic Patients and Tolerant Individuals
Coulter, E. M., Jenkinson, C., Farrell, J., Lavergne, S. N., Pease, C., White, A., . . . Naisbitt, D. J. (2010). Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in <i>p</i>-Phenylenediamine Allergic Patients and Tolerant Individuals. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130(1), 161-174. doi:10.1038/jid.2009.187
Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals
Coulter, E. M., Jenkinson, C., Farrell, J., Lavergne, S. N., Pease, C., White, A., . . . Naisbitt, D. J. (2010). Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals. Journal of Investigative Dermatology, 130(1), 161-174. doi:10.1038/jid.2009.187
Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries
Srivastava, A., Lian, L. -Y., Maggs, J. L., Chaponda, M., Pirmohamed, M., Williams, D. P., & Park, B. K. (2010). Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries. DRUG METABOLISM AND DISPOSITION, 38(1), 122-132. doi:10.1124/dmd.109.028688
Role of reactive metabolites in drug-induced hepatotoxicity.
Srivastava, A., Maggs, J. L., Antoine, D. J., Williams, D. P., Smith, D. A., & Park, B. K. (2010). Role of reactive metabolites in drug-induced hepatotoxicity.. Hanbook of Experimental Pharmacology, 196, 165-194.
The potential of cytokines as safety biomarkers for drug-induced liver injury.
Laverty, H. G., Antoine, D. J., Benson, C., Chaponda, M., Williams, D., & Park, B. K. (2010). The potential of cytokines as safety biomarkers for drug-induced liver injury.. Eur J Clin Pharmacol, 66(10), 961-976.
2009
Mechanism-based bioanalysis and biomarkers for hepatic chemical stress
Antoine, D. J., Mercer, A. E., Williams, D. P., & Park, B. K. (2009). Mechanism-based bioanalysis and biomarkers for hepatic chemical stress. XENOBIOTICA, 39(8), 565-577. doi:10.1080/00498250903046993
High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis <i>In Vivo</i>
Antoine, D. J., Williams, D. P., Kipar, A., Jenkins, R. E., Regan, S. L., Sathish, J. G., . . . Park, B. K. (2009). High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis <i>In Vivo</i>. TOXICOLOGICAL SCIENCES, 112(2), 521-531. doi:10.1093/toxsci/kfp235
Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis
Mercer, A. E., Regan, S. L., Hirst, C. M., Graham, E. E., Antoine, D. J., Benson, C. A., . . . Park, B. K. (2009). Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis. TOXICOLOGY AND APPLIED PHARMACOLOGY, 239(3), 297-305. doi:10.1016/j.taap.2009.05.027
Characterization and Quantification of Mercapturate and Glutathione Conjugates of Nevirapine
Srivastava, A., Williams, D. P., Maggs, J. L., Lian, L. -Y., Chaponda, M., Gardner, I., . . . Park, K. (2009). Characterization and Quantification of Mercapturate and Glutathione Conjugates of Nevirapine. In TOXICOLOGY Vol. 262 (pp. 6-7). doi:10.1016/j.tox.2009.04.051
Pharmacokinetic investigation into the mechanism of toxicity of Furosemide and its thiophene analogue
Webb, H., Duckworth, J., Turnpenny, P., Gardner, I., Smith, D., Park, K., & Williams, D. (2009). Pharmacokinetic investigation into the mechanism of toxicity of Furosemide and its thiophene analogue. In TOXICOLOGY Vol. 262 (pp. 23-24). doi:10.1016/j.tox.2009.04.029
Clearing the MIST (metabolites in safety testing) of time: The impact of duration of administration on drug metabolite toxicity
Smith, D. A., Obach, R. S., Williams, D. P., & Park, B. K. (2009). Clearing the MIST (metabolites in safety testing) of time: The impact of duration of administration on drug metabolite toxicity. CHEMICO-BIOLOGICAL INTERACTIONS, 179(1), 60-67. doi:10.1016/j.cbi.2008.09.022
2008
Understanding the role of reactive metabolites in drug-induced hepatotoxicity: state of the science
Antoine, D. J., Williams, D. P., & Park, B. K. (2008). Understanding the role of reactive metabolites in drug-induced hepatotoxicity: state of the science. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 4(11), 1415-1427. doi:10.1517/17425255.4.11.1415
Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore
Graham, E. E., Walsh, R. J., Hirst, C. M., Maggs, J. L., Martin, S., Wild, M. J., . . . Park, B. K. (2008). Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore. The Journal of Pharmacology and Experimental Therapeutics, 326(2), 657-671. doi:10.1124/jpet.107.135483
Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore
Graham, E. E., Walsh, R. J., Hirst, C. M., Maggs, J. L., Martin, S., Wild, M. J., . . . Park, B. K. (2008). Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 326(2), 657-671. doi:10.1124/jpet.107.135483
Acridinediones: Selective and Potent Inhibitors of the Malaria Parasite Mitochondrial bc1 Complex
Biagini, G. A., Fisher, N., Berry, N., Stocks, P. A., Meunier, B., Williams, D. P., . . . Ward, S. A. (2008). Acridinediones: Selective and Potent Inhibitors of the Malaria Parasite Mitochondrial bc1 Complex. Molecular Pharmacology, 73(5), 1347-1355. doi:10.1124/mol.108.045120
Acridinediones:: Selective and potent inhibitors of the malaria parasite mitochondrial <i>bc</i><sub>1</sub> complex
Biagini, G. A., Fisher, N., Berry, N., Stocks, P. A., Meunier, B., Williams, D. P., . . . Ward, S. A. (2008). Acridinediones:: Selective and potent inhibitors of the malaria parasite mitochondrial <i>bc</i><sub>1</sub> complex. MOLECULAR PHARMACOLOGY, 73(5), 1347-1355. doi:10.1124/mol.108.045120
α1-adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice
Randle, L. E., Sathish, J. G., Kitteringham, N. R., Macdonald, I., Williams, D. P., & Park, B. K. (2008). α1-adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice. BRITISH JOURNAL OF PHARMACOLOGY, 153(4), 820-830. doi:10.1038/sj.bjp.0707620
Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice
Randle, L. E., Goldring, C. E. P., Benson, C. A., Metcalfe, P. N., Kitteringham, N. R., Park, B. K., & Williams, D. P. (2008). Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice. TOXICOLOGY, 243(3), 249-260. doi:10.1016/j.tox.2007.10.011
2007
The Metabolism and Toxicity of Furosemide in the Wistar Rat and CD-1 Mouse: a Chemical and Biochemical Definition of the Toxicophore
Williams, D. P., Antoine, D. J., Butler, P. J., Jones, R., Randle, L., Payne, A., . . . Park, B. K. (2007). The Metabolism and Toxicity of Furosemide in the Wistar Rat and CD-1 Mouse: a Chemical and Biochemical Definition of the Toxicophore. The Journal of Pharmacology and Experimental Therapeutics, 322(3), 1208-1220. doi:10.1124/jpet.107.125302
The metabolism and toxicity of furosemide in the Wistar rat and CD-1 mouse: a chemical and biochemical definition of the toxicophore
Williams, D. P., Antoine, D. J., Butler, P. J., Jones, R., Randle, L., Payne, A., . . . Park, B. K. (2007). The metabolism and toxicity of furosemide in the Wistar rat and CD-1 mouse: a chemical and biochemical definition of the toxicophore. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 322(3), 1208-1220. doi:10.1124/jpet.107.125302
Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice
Randle, L. E., Goldring, C. E. P., Benson, C., Metcalfe, P., Kitteringham, N. R., Park, B. K., & Williams, D. P. (2007). Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice. Toxicology, E-pub, 14.
2006
Selection of new chemical entities with decreased potential for adverse drug reactions
Park, K. B., Dalton-Brown, E., Hirst, C., & Williams, D. P. (2006). Selection of new chemical entities with decreased potential for adverse drug reactions. EUROPEAN JOURNAL OF PHARMACOLOGY, 549(1-3), 1-8. doi:10.1016/j.ejphar.2006.08.025
Toxicophores: Investigations in drug safety
Williams, D. P. (2006). Toxicophores: Investigations in drug safety. TOXICOLOGY, 226(1), 3-13. doi:10.1016/j.tox.2006.05.101
Relative and absolute quantitative expression profiling of cytochromes P450 using isotope-coded affinity tags
Jenkins, R. E., Kitteringham, N. R., Hunter, C. L., Webb, S., Hunt, T. J., Elsby, R., . . . Park, B. K. (2006). Relative and absolute quantitative expression profiling of cytochromes P450 using isotope-coded affinity tags. PROTEOMICS, 6(6), 1934-1947. doi:10.1002/pmic.200500432
Synergistic interactions between commonly used food additives in a developmental neurotoxicity test
Lau, K., McLean, W. G., Williams, D. P., & Howard, C. V. (2006). Synergistic interactions between commonly used food additives in a developmental neurotoxicity test. TOXICOLOGICAL SCIENCES, 90(1), 178-187. doi:10.1093/toxsci/kfj073
Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes
Goldring, C. E. P., Kitteringham, N. R., Jenkins, R., Lovatt, C. A., Randle, L. E., Abdullah, A., . . . Park, B. K. (2006). Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 290(1), C104-C115. doi:10.1152/ajpcell.00133.2005
Selection of new chemical entities with decreased potential for adverse drug reactions.
Park, K. B., Dalton-Brown, E., Hirst, C., & Williams, D. P. (2006). Selection of new chemical entities with decreased potential for adverse drug reactions.. Eur J Pharmacol., 1-3(549), 1-8.
Toxicophores: investigations in drug safety.
Williams, D. P. (2006). Toxicophores: investigations in drug safety.. Toxicology., 1(226), 1-11.
2005
The role of metabolic activation in drug-induced hepatotoxicity
Park, B. K., Kitteringham, N. R., Maggs, J. L., Pirmohamed, M., & Williams, D. P. (2005). The role of metabolic activation in drug-induced hepatotoxicity. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 45, 177-202. doi:10.1146/annurev.pharmtox.45.120403.100058
Investigation of toxic metabolites during drug development.
Park, K., Williams, D. P., Naisbitt, D. J., Kitteringham, N. R., & Pirmohamed, M. (2005). Investigation of toxic metabolites during drug development.. Toxicology and applied pharmacology, 207(2 Suppl), 425-434. doi:10.1016/j.taap.2005.02.029
2004
Time course toxicogenomic profiles in CD-1 mice after nontoxic and nonlethal hepatotoxic paracetamol administration.
Williams, D. P., Garcia-Allan, C., Hanton, G., LeNet, J. L., Provost, J. P., Brain, P., . . . Park, B. K. (2004). Time course toxicogenomic profiles in CD-1 mice after nontoxic and nonlethal hepatotoxic paracetamol administration.. Chemical research in toxicology, 17(12), 1551-1561. doi:10.1021/tx049846x
Activation of hepatic Nrf2 <i>in vivo</i> by acetaminophen in CD-1 mice
Goldring, C. E. P., Kitteringham, N. R., Elsby, R., Randle, L. E., Clement, Y. N., Williams, D. P., . . . Park, B. K. (2004). Activation of hepatic Nrf2 <i>in vivo</i> by acetaminophen in CD-1 mice. HEPATOLOGY, 39(5), 1267-1276. doi:10.1002/hep.20183
Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10β-(2-hydroxyethyl)deoxoartemisinin
Jeyadevan, J. P., Bray, P. G., Chadwick, J., Mercer, A. E., Byrne, A., Ward, S. A., . . . O'Neill, P. M. (2004). Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10β-(2-hydroxyethyl)deoxoartemisinin. JOURNAL OF MEDICINAL CHEMISTRY, 47(5), 1290-1298. doi:10.1021/jm030974c
Antimalarial and Antitumor Evaluation of Novel C-10 Non-Acetal Dimers of 10β-(2-Hydroxyethyl)deoxoartemisinin
Jeyadevan, J. P., Bray, P. G., Chadwick, J., Mercer, A. E., Byrne, A., Ward, S. A., . . . O'Neill, P. M. (2004). Antimalarial and Antitumor Evaluation of Novel C-10 Non-Acetal Dimers of 10β-(2-Hydroxyethyl)deoxoartemisinin. Journal of Medicinal Chemistry, 47(5), 1290-1298. doi:10.1021/jm030974c
2003
Idiosyncratic toxicity: the role of toxicophores and bioactivation
Williams, D. P., & Park, B. K. (2003). Idiosyncratic toxicity: the role of toxicophores and bioactivation. DRUG DISCOVERY TODAY, 8(22), 1044-1050. doi:10.1016/S1359-6446(03)02888-5
Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro
Williams, D. P., O'Donnell, C. J. L., Maggs, J. L., Leeder, J. S., Uetrecht, J., Pirmohamed, M., & Park, B. K. (2003). Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro. CHEMICAL RESEARCH IN TOXICOLOGY, 16(10), 1359-1364. doi:10.1021/tx034035z
Adverse drug reactions, transcription factors and transcriptomics
Williams, D. P., & O'Donnell, C. (2003). Adverse drug reactions, transcription factors and transcriptomics. Comparative Clinical Pathology, 12(1), 1-10. doi:10.1007/s00580-003-0475-1
2002
Are chemically reactive metabolites responsible for adverse reactions to drugs?
Williams, D. P., Kitteringham, N. R., Naisbitt, D. J., Pirmohamed, M., Smith, D. A., & Park, B. K. (2002). Are chemically reactive metabolites responsible for adverse reactions to drugs?. Current drug metabolism, 3(4), 351-366. doi:10.2174/1389200023337423
Toxicophores: Groups and metabolic routes associated with increased safety risk
Williams, D. P., & Naisbitt, D. J. (2002). Toxicophores: Groups and metabolic routes associated with increased safety risk. CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 5(1), 104-115. Retrieved from https://www.webofscience.com/
Are chemically reactive metabolites responsible for adverse reactions to drugs?
Williams, D. P., Kitteringham, N. R., Naisbitt, D. J., Pirmohamed, M., Smith, D. A., & Park, B. K. (2002). Are chemically reactive metabolites responsible for adverse reactions to drugs?. Curr Drug Metab, 3(4), 351-366.
2001
Reactive metabolites and their role in drug reactions
Naisbitt, D. J., Williams, D. P., Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (2001). Reactive metabolites and their role in drug reactions. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 1(4), 317-325. Retrieved from https://www.webofscience.com/
Reactive metabolites and their role in drug reactions.
Naisbitt, D. J., Williams, D. P., Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (2001). Reactive metabolites and their role in drug reactions.. Curr Opin Allergy Clin Immunol., 4(1), 317-325.
2000
Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine
Williams, D. P., Pirmohamed, M., Naisbitt, D. J., Uetrecht, J. P., & Park, B. K. (2000). Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine. MOLECULAR PHARMACOLOGY, 58(1), 207-216. doi:10.1124/mol.58.1.207
1998
Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs
Naisbitt, D. J., Williams, D. P., O'Neill, P. M., Maggs, J. L., Willock, D. J., Pirmohamed, M., & Park, B. K. (1998). Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs. CHEMICAL RESEARCH IN TOXICOLOGY, 11(12), 1586-1595. doi:10.1021/tx980148k
Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs.
Naisbitt, D. J., Williams, D. P., O'Neill, P. M., Maggs, J. L., Willock, D. J., Pirmohamed, M., & Park, B. K. (1998). Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs.. Chem Res Toxicol., 12(11), 1586-1595.
1997
Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: Possible role in agranulocytosis
Williams, D. P., Pirmohamed, M., Naisbitt, D. J., Maggs, J. L., & Park, B. K. (1997). Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: Possible role in agranulocytosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 283(3), 1375-1382. Retrieved from https://www.webofscience.com/
Disposition of amodiaquine and related antimalarial agents in human neutrophils: Implications for drug design
Naisbitt, D. J., Ruscoe, J. E., Williams, D., ONeill, P. M., Pirmohamed, M., & Park, B. K. (1997). Disposition of amodiaquine and related antimalarial agents in human neutrophils: Implications for drug design. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 280(2), 884-893. Retrieved from https://www.webofscience.com/
Bioactivation and inactivation of aflatoxin B-1 by human, mouse and rat liver preparations: Effect on SCE in human mononuclear leucocytes
Wilson, A. S., Williams, D. P., Davis, C. D., Tingle, M. D., & Park, B. K. (1997). Bioactivation and inactivation of aflatoxin B-1 by human, mouse and rat liver preparations: Effect on SCE in human mononuclear leucocytes. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 373(2), 257-264. doi:10.1016/S0027-5107(96)00205-9
Corrigendum
Corrigendum (1997). Toxicology, 120(1), 75. doi:10.1016/s0300-483x(96)03644-x
Disposition of amodiaquine and related antimalarial agents in human neutrophils: implications for drug design.
Naisbitt, D. J., Ruscoe, J. E., Williams, D., O'Neill, P. M., Pirmohamed, M., & Park, B. K. (1997). Disposition of amodiaquine and related antimalarial agents in human neutrophils: implications for drug design.. J Pharmacol Exp Ther., 2(280), 884-893.
1996
Characterisation of the toxic metabolite(s) of naphthalene
Wilson, A. S., Davis, C. D., Williams, D. P., Buckpitt, A. R., Pirmohamed, M., & Park, B. K. (1996). Characterisation of the toxic metabolite(s) of naphthalene. TOXICOLOGY, 114(3), 233-242. doi:10.1016/S0300-483X(96)03515-9
Intracellular glutathione in the peripheral blood cells of HIV-infected patients: failure to show a deficiency
Pirmohamed, M., Williams, D., Tingle, M. D., Barry, M., Khoo, S. H., OʼMahony, C., . . . Park, B. K. (1996). Intracellular glutathione in the peripheral blood cells of HIV-infected patients: failure to show a deficiency. AIDS, 10(5), 501-507. doi:10.1097/00002030-199605000-00008
Characterisation of the toxic metabolite(s) of naphthalene.
Wilson, A. S., Davis, C. D., Williams, D. P., Buckpitt, A. R., Pirmohamed, M., & Park, B. K. (1996). Characterisation of the toxic metabolite(s) of naphthalene.. Toxicology., 3(114), 233-242.
Intracellular glutathione in the peripheral blood cells of HIV-infected patients: Failure to show a deficiency
Pirmohamed, M., Williams, D., Tingle, M. D., Barry, M., Khoo, S. H., OMahony, C., . . . Park, B. K. (1996). Intracellular glutathione in the peripheral blood cells of HIV-infected patients: Failure to show a deficiency. AIDS, 10(5), 501-507. doi:10.1097/00002030-199605000-00008
1995
The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man
Maggs, J. L., Williams, D., Pirmohamed, M., & Park, B. K. (1995). The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 275(3), 1463-1475. Retrieved from https://www.webofscience.com/
METABOLISM AND BIOACTIVATION OF CLOZAPINE BY HUMAN LIVER IN-VITRO
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