Publications
2023
Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19.
Sidhu, J. K., Siggins, M. K., Liew, F., Russell, C. D., Uruchurtu, A. S. S., Davis, C., . . . ISARIC4C investigators. (2023). Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19.. The Journal of infectious diseases, jiad590. doi:10.1093/infdis/jiad590
Sodium valproate causes pancreatic injury in vitro and in vivo via dysregulation of one carbon metabolism
Cai, W., Chvanov, M., Awais, M., Meng, X., Latawiec, D., Brown, J., . . . Sutton, R. (2023). Sodium valproate causes pancreatic injury in vitro and in vivo via dysregulation of one carbon metabolism. Pancreatology, 23, e20-e21. doi:10.1016/j.pan.2023.06.453
Transcriptomic profiling reveals molecular and inflammatory gene signatures of acute pancreatitis in cyclophilin D knockout and wild-type murine blood
Wu, D., Mukherjee, R., Armstrong, J., Wen, L., Sud, A., Latawiec, D., . . . Sutton, R. (2023). Transcriptomic profiling reveals molecular and inflammatory gene signatures of acute pancreatitis in cyclophilin D knockout and wild-type murine blood. Pancreatology, 23, e67. doi:10.1016/j.pan.2023.06.573
International Pediatric COVID-19 Severity Over the Course of the Pandemic
Zhu, Y., Almeida, F. J., Baillie, J. K., Bowen, A. C., Britton, P. N., Brizuela, M. E., . . . Short, K. R. (2023). International Pediatric COVID-19 Severity Over the Course of the Pandemic. JAMA PEDIATRICS. doi:10.1001/jamapediatrics.2023.3117
Leukocyte gene expression profiles in fatty acid ethyl ester-induced acute pancreatitis
Wu, D., Mukherjee, R., Armstrong, J., Wen, L., Sud, A., Latawiec, D., . . . Sutton, R. (2023). Leukocyte gene expression profiles in fatty acid ethyl ester-induced acute pancreatitis. In BRITISH JOURNAL OF SURGERY Vol. 110 (pp. III5). doi:10.1093/bjs/znad101.016
Mitochondrial P53 inhibition ameliorates acute pancreatitis through reduction of mitochondrial injury and cell necrosis
Awais, M., Cai, W., Latawiec, D., Mukherjee, R., Chvanov, M., Tepikin, A., . . . Sutton, R. (2023). Mitochondrial P53 inhibition ameliorates acute pancreatitis through reduction of mitochondrial injury and cell necrosis. In BRITISH JOURNAL OF SURGERY Vol. 110. doi:10.1093/bjs/znad101.101
SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination
Liew, F., Talwar, S., Cross, A., Willett, B. J., Scott, S., Logan, N., . . . Openshaw, P. J. M. (2023). SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. EBIOMEDICINE, 87. doi:10.1016/j.ebiom.2022.104402
2022
Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patients.
Wu, D., Jia, Y., Cai, W., Huang, Y., Kattakayam, A., Latawiec, D., . . . Peng, J. (2022). Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patients.. Front Cell Infect Microbiol, 12, 1044188. doi:10.3389/fcimb.2022.1044188
Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study
Vink, E., Davis, C., MacLean, A., Pascall, D., McDonald, S. E., Gunson, R., . . . Ho, A. (2022). Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. OPEN FORUM INFECTIOUS DISEASES, 9(11). doi:10.1093/ofid/ofac531
Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.
Siggins, M. K., Davies, K., Fellows, R., Thwaites, R. S., Baillie, J. K., Semple, M. G., . . . ISARIC4C Investigators. (2022). Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.. Immunology. doi:10.1111/imm.13585
Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19
Norris, T., Razieh, C., Zaccardi, F., Yates, T., Islam, N., Gillies, C. L., . . . Khunti, K. (2022). Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19. HEART, 108(15), 1200-1208. doi:10.1136/heartjnl-2021-320047
EASY-APP: An artificial intelligence model and application for early and easy prediction of severity in acute pancreatitis
Kui, B., Pinter, J., Molontay, R., Nagy, M., Farkas, N., Gede, N., . . . Hegyi, P. (2022). EASY-APP: An artificial intelligence model and application for early and easy prediction of severity in acute pancreatitis. CLINICAL AND TRANSLATIONAL MEDICINE, 12(6). doi:10.1002/ctm2.842
Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission
Relph, K. A., Russell, C. D., Fairfield, C. J., Turtle, L., de Silva, T. I., Siggins, M. K., . . . Young, P. (2022). Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission. Open Forum Infectious Diseases, 9(5). doi:10.1093/ofid/ofac179
Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study
Narhi, F., Moonesinghe, S. R., Shenkin, S. D., Drake, T. M., Mulholland, R. H., Donegan, C., . . . Docherty, A. B. (2022). Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. LANCET DIGITAL HEALTH, 4(4). Retrieved from https://www.webofscience.com/
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (2022). SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. Cell, 185(3), 467-484.e15. doi:10.1016/j.cell.2021.12.046
Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study
Sullivan, M. K., Lees, J. S., Drake, T. M., Docherty, A. B., Oates, G., Hardwick, H. E., . . . Mark, P. B. (2022). Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study. NEPHROLOGY DIALYSIS TRANSPLANTATION, 37(2), 271-284. doi:10.1093/ndt/gfab303
Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol
Knight, S. R., Gupta, R. K., Ho, A., Pius, R., Buchan, I., Carson, G., . . . Harrison, E. M. (2022). Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. THORAX, 77(6), 606-615. doi:10.1136/thoraxjnl-2021-217629
2021
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells
de, S. T. I., Liu, G., Lindsey, B. B., Dong, D., Moore, S. C., Hsu, N. S., . . . Dong, T. (2021). The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. ISCIENCE, 24(11). doi:10.1016/j.isci.2021.103353
Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study
Hurst, E. A., Mellanby, R. J., Handel, I., Griffith, D. M., Rossi, A. G., Walsh, T. S., . . . Russell, C. D. (2021). Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study. BMJ OPEN, 11(10). doi:10.1136/bmjopen-2021-055435
Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study
Russell, C. D., Fairfield, C. J., Drake, T. M., Turtle, L., Seaton, R. A., Wootton, D. G., . . . Ho, A. (2021). Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. LANCET MICROBE, 2(8), E354-E365. doi:10.1016/S2666-5247(21)00090-2
Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study
Drake, T. M., Riad, A. M., Fairfield, C. J., Egan, C., Knight, S. R., Pius, R., . . . Semple, M. G. (2021). Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. LANCET, 398(10296), 223-237. Retrieved from https://www.webofscience.com/
Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK
Docherty, A., Mulholland, R., Lone, N. I., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . Semple, M. (2021). Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 773-785. doi:10.1016/S2213-2600(21)00175-2
Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.
Drake, T. M., Fairfield, C. J., Pius, R., Knight, S. R., Norman, L., Girvan, M., . . . ISARIC4C Investigators. (2021). Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.. The Lancet. Rheumatology, 3(7), e498-e506. doi:10.1016/s2665-9913(21)00104-1
Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK
Bloom, C. I., Drake, T. M., Docherty, A. B., Lipworth, B. J., Johnston, S. L., Nguyen-Van-Tam, J. S., . . . Openshaw, P. J. M. (2021). Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 699-711. doi:10.1016/S2213-2600(21)00013-8
Protective Effects of Necrostatin-1 in Acute Pancreatitis: Partial Involvement of Receptor Interacting Protein Kinase 1
Ouyang, Y., Wen, L., Armstrong, J. A., Chvanov, M., Latawiec, D., Cai, W., . . . Criddle, D. N. (2021). Protective Effects of Necrostatin-1 in Acute Pancreatitis: Partial Involvement of Receptor Interacting Protein Kinase 1. CELLS, 10(5). doi:10.3390/cells10051035
Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study
Gupta, R. K., Harrison, E. M., Ho, A., Docherty, A. B., Knight, S. R., van Smeden, M., . . . Noursadeghi, M. (2021). Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(4), 349-359. doi:10.1016/S2213-2600(20)30559-2
Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.
Thwaites, R. S., Sanchez Sevilla Uruchurtu, A., Siggins, M. K., Liew, F., Russell, C. D., Moore, S. C., . . . ISARIC4C investigators. (2021). Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.. Science Immunology, 6(57). doi:10.1126/sciimmunol.abg9873
2020
Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020
Thompson, C. P., Grayson, N. E., Paton, R. S., Bolton, J. S., Lourenco, J., Penman, B. S., . . . Simmonds, P. (2020). Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. EUROSURVEILLANCE, 25(42), 33-41. doi:10.2807/1560-7917.ES.2020.25.42.2000685
Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.
Drake, T. M., Docherty, A. B., Harrison, E. M., Quint, J. K., Adamali, H., Agnew, S., . . . ISARIC4C Investigators. (2020). Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.. Am J Respir Crit Care Med. doi:10.1164/rccm.202007-2794OC
Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.
Knight, S. R., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T. M., . . . ISARIC4C investigators. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.. BMJ: British Medical Journal, 370. doi:10.1136/bmj.m3339
Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study
Swann, O., Holden, K., Turtle, L., Pollock, L., Fairfield, C., Drake, T., . . . ISARIC Coronavirus Clinical Characterisation Consortium (ISARIC4C) Investigators. (2020). Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study. BMJ, 370. doi:10.1136/bmj.m3249
Knockout of the Mitochondrial Calcium Uniporter Strongly Suppresses Stimulus-Metabolism Coupling in Pancreatic Acinar Cells but Does not Reduce Severity of Experimental Acute Pancreatitis
Chvanov, M., Voronina, S., Zhang, X., Telnova, S., Chard, R., Ouyang, Y., . . . Tepikin, A. V. (2020). Knockout of the Mitochondrial Calcium Uniporter Strongly Suppresses Stimulus-Metabolism Coupling in Pancreatic Acinar Cells but Does not Reduce Severity of Experimental Acute Pancreatitis. CELLS, 9(6). doi:10.3390/cells9061407
2018
Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shift
Armstrong, J. A., Cash, N. J., Ouyang, Y., Morton, J. C., Chvanov, M., Latawiec, D., . . . Criddle, D. N. (2018). Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shift. JOURNAL OF BIOLOGICAL CHEMISTRY, 293(21), 8032-8047. doi:10.1074/jbc.RA118.003200
TRO40303 Ameliorates Alcohol-Induced Pancreatitis Through Reduction of Fatty Acid Ethyl Ester-Induced Mitochondrial Injury and Necrotic Cell Death
Javed, M. A., Wen, L., Awais, M., Latawiec, D., Huang, W., Chvanov, M., . . . Sutton, R. (2018). TRO40303 Ameliorates Alcohol-Induced Pancreatitis Through Reduction of Fatty Acid Ethyl Ester-Induced Mitochondrial Injury and Necrotic Cell Death. PANCREAS, 47(1), 18-24. doi:10.1097/MPA.0000000000000953
2017
Chai-Qin-Cheng-Qi decoction alleviates multiple organ dysfunction syndrome by upregulating Nrf2 in rodent models of acute pancreatitis and intestinal ischaemia-reperfusion injury
Zhang, X., Shi, N., Jin, T., Latawiec, D., Wei, A., Zhang, C., . . . Sutton, R. (2017). Chai-Qin-Cheng-Qi decoction alleviates multiple organ dysfunction syndrome by upregulating Nrf2 in rodent models of acute pancreatitis and intestinal ischaemia-reperfusion injury. Pancreatology, 17(3), S30. doi:10.1016/j.pan.2017.05.095
Selective inhibition of BET proteins reduces pancreatic damage and systemic inflammation in bile acid- and fatty acid ethyl ester- but not caerulein-induced acute pancreatitis
Huang, W., Haynes, A. C., Mukherjee, R., Wen, L., Latawiec, D., Tepikin, A. V., . . . Sutton, R. (2017). Selective inhibition of BET proteins reduces pancreatic damage and systemic inflammation in bile acid- and fatty acid ethyl ester- but not caerulein-induced acute pancreatitis. Pancreatology, 17(5), 689-697. doi:10.1016/j.pan.2017.06.005
Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release
Huang, W., Cane, M. C., Mukherjee, R., Szatmary, P., Zhang, X., Elliott, V., . . . Sutton, R. (2017). Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release. Gut, 66(2), 301-313. doi:10.1136/gutjnl-2015-309363
2016
Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis
Fjeld, K., Beer, S., Johnstone, M., Zimmer, C., Moessner, J., Ruffert, C., . . . Rosendahl, J. (2016). Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis. PLOS ONE, 11(11). doi:10.1371/journal.pone.0165567
Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP
Mukherjee, R., Mareninova, O. A., Odinokova, I. V., Huang, W., Murphy, J., Chvanov, M., . . . Unit, N. I. H. R. P. B. R. (2016). Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP. GUT, 65(08), 1333-1346. doi:10.1136/gutjnl-2014-308553
Small Molecule Inhibitors of Cyclophilin D To Protect Mitochondrial Function as a Potential Treatment for Acute Pancreatitis
Shore, E. R., Awais, M., Kershaw, N. M., Gibson, R. R., Pandalanen, S., Latawiec, D., . . . Sutton, R. (2016). Small Molecule Inhibitors of Cyclophilin D To Protect Mitochondrial Function as a Potential Treatment for Acute Pancreatitis. JOURNAL OF MEDICINAL CHEMISTRY, 59(06), 2596-2611. doi:10.1021/acs.jmedchem.5b01801
2015
Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models
Wen, L., Voronina, S., Javed, M. A., Awais, M., Szatmary, P., Latawiec, D., . . . Sutton, R. (2015). Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models. GASTROENTEROLOGY, 149(2), 481-492.e7. doi:10.1053/j.gastro.2015.04.015
ORAI INHIBITION PREVENTS CYTOSOLIC CA2+OVERLOAD AND ACUTE PANCREATITIS
Wen, L., Voronina, S., Javed, M. A., Awais, M., Szatmary, P., Latawiec, D., . . . Sutton, R. (2015). ORAI INHIBITION PREVENTS CYTOSOLIC CA2+OVERLOAD AND ACUTE PANCREATITIS. In GUT Vol. 64 (pp. A303-A304). doi:10.1136/gutjnl-2015-309861.656
The role of receptor interacting protein kinase 1 (RIPK1) in bile acid-induced pancreatic acinar cell death
Ouyang, Y., Voronina, S., Chvanov, M., Wen, L., Latawiec, D., Awais, M., . . . Criddle, D. N. (2015). The role of receptor interacting protein kinase 1 (RIPK1) in bile acid-induced pancreatic acinar cell death. Pancreatology, 15(3), S8. doi:10.1016/j.pan.2015.05.065
2014
Overview of nano-drugs characteristics for clinical application: the journey from the entry to the exit point
Bose, T., Latawiec, D., Mondal, P. P., & Mandal, S. (2014). Overview of nano-drugs characteristics for clinical application: the journey from the entry to the exit point. Journal of Nanoparticle Research, 16(8). doi:10.1007/s11051-014-2527-7
Association of carboxyl-ester lipase variable nucleotide tandem repeat with alcoholic chronic pancreatitis and alcoholic liver disease
Johnstone, M., Miyajima, F., Liloglou, T., Brown, L., Winn, S., Davies, K., . . . Sutton, R. (2014). Association of carboxyl-ester lipase variable nucleotide tandem repeat with alcoholic chronic pancreatitis and alcoholic liver disease. Pancreatology, 14(3), S57. doi:10.1016/j.pan.2014.05.573
Expression of human cationic trypsinogen (PRSS1) in murine acinar cells promotes pancreatitis and apoptotic cell death
Athwal, T., Huang, W., Mukherjee, R., Latawiec, D., Chvanov, M., Clarke, R., . . . Vlatkovic, N. (2014). Expression of human cationic trypsinogen (PRSS1) in murine acinar cells promotes pancreatitis and apoptotic cell death. Cell Death and Disease, 5. doi:10.1038/cddis.2014.120
2012
Review of experimental animal models of biliary acute pancreatitis and recent advances in basic research.
Wan, M. H., Huang, W., Latawiec, D., Jiang, K., Booth, D. M., Elliott, V., . . . Xia, Q. (2012). Review of experimental animal models of biliary acute pancreatitis and recent advances in basic research.. HPB : the official journal of the International Hepato Pancreato Biliary Association, 14(2), 73-81. doi:10.1111/j.1477-2574.2011.00408.x