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2024

Omeprazole-Associated Atypical Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in a Patient with Positive In Vitro Diagnostic Testing to Multiple Proton Pump Inhibitors.

Grice, S., Hammond, S., Hampson, L., Wagner, A., & Naisbitt, D. J. (2024). Omeprazole-Associated Atypical Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in a Patient with Positive In Vitro Diagnostic Testing to Multiple Proton Pump Inhibitors.. Chemical research in toxicology, 37(9), 1484-1487. doi:10.1021/acs.chemrestox.4c00225

DOI
10.1021/acs.chemrestox.4c00225
Journal article

Lymphocyte transformation tests predict delayed-type allergy to piperacillin/tazobactam in patients with cystic fibrosis.

Roehmel, J. F., Rohrbach, A., Staab, D., Mall, M. A., Ogese, M., Doerfler, F., & Naisbitt, D. (2024). Lymphocyte transformation tests predict delayed-type allergy to piperacillin/tazobactam in patients with cystic fibrosis.. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 23(3), 573-578. doi:10.1016/j.jcf.2023.12.003

DOI
10.1016/j.jcf.2023.12.003
Journal article

Glycolysis: An early marker for vancomycin-specific T-cell activation.

Gardner, J., Hammond, S., Jensen, R., Gibson, A., Krantz, M. S., Ardern-Jones, M., . . . Naisbitt, D. J. (2024). Glycolysis: An early marker for vancomycin-specific T-cell activation.. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 54(1), 21-33. doi:10.1111/cea.14423

DOI
10.1111/cea.14423
Journal article

Patients with <scp>naproxen‐induced</scp> liver injury display T‐cell memory responses toward an oxidative (S)‐<scp>O‐Desmethyl</scp> Naproxen metabolite but not the acyl glucuronide

Thomson, P., Fragkas, N., Kafu, L. M., Aithal, G. P., Lucena, M. I., Terracciano, L., . . . Naisbitt, D. J. (n.d.). Patients with <scp>naproxen‐induced</scp> liver injury display T‐cell memory responses toward an oxidative (S)‐<scp>O‐Desmethyl</scp> Naproxen metabolite but not the acyl glucuronide. Allergy. doi:10.1111/all.15830

DOI
10.1111/all.15830
Journal article

Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-Desmethyl Naproxen metabolite but not the acyl glucuronide

Thomson, P., Fragkas, N., Kafu, L. M., Aithal, G. P., Lucena, M. I., Terracciano, L., . . . Naisbitt, D. J. (2023). Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-Desmethyl Naproxen metabolite but not the acyl glucuronide. In ALLERGY. doi:10.1111/all.15830

DOI
10.1111/all.15830
Conference Paper

2023

P1095: COVID-19 VACCINE RESPONSES IN FOLLICULAR LYMPHOMA: DETERMINANTS OF HUMORAL AND CELLULAR IMMUNITY IN THE PETREA TRIAL OF FRONTLINE CHEMOIMMUNOTHERAPY

Jer Lim, Y., Ward, V., Farrell, L., Naisbitt, D., Brown, A., Phillips, E., . . . Pettitt, A. (n.d.). P1095: COVID-19 VACCINE RESPONSES IN FOLLICULAR LYMPHOMA: DETERMINANTS OF HUMORAL AND CELLULAR IMMUNITY IN THE PETREA TRIAL OF FRONTLINE CHEMOIMMUNOTHERAPY. HemaSphere, 7(S3), e49729ac. doi:10.1097/01.hs9.0000971276.49729.ac

DOI
10.1097/01.hs9.0000971276.49729.ac
Journal article

Dapsone hypersensitivity syndrome

Zhao, Q., Sun, L., Sun, Y., Naisbitt, D., Liu, H., & Zhang, F. (2023). Dapsone hypersensitivity syndrome. CHINESE MEDICAL JOURNAL, 136(13), 1560-1562. doi:10.1097/CM9.0000000000002492

DOI
10.1097/CM9.0000000000002492
Journal article

2022

Pathology of T-cell-mediated drug hypersensitivity reactions and impact of tolerance mechanisms on patient susceptibility

Line, J., Thomson, P., & Naisbitt, D. J. (2022). Pathology of T-cell-mediated drug hypersensitivity reactions and impact of tolerance mechanisms on patient susceptibility. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 22(4), 226-233. doi:10.1097/ACI.0000000000000834

DOI
10.1097/ACI.0000000000000834
Journal article

T-cell-mediated hypersensitivity to lumacaftor and ivacaftor in cystic fibrosis

Semic-Jusufagic, A., Ogese, M. O., Edwards, C., Wilkinson, M., Nissenbaum, C., Lee, T., . . . Naisbitt, D. J. (2022). T-cell-mediated hypersensitivity to lumacaftor and ivacaftor in cystic fibrosis. PEDIATRIC ALLERGY AND IMMUNOLOGY, 33(6). doi:10.1111/pai.13815

DOI
10.1111/pai.13815
Journal article

Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity

Hammond, S., Olsson-Brown, A., Grice, S., Gibson, A., Gardner, J., Castrejon-Flores, J. L., . . . Naisbitt, D. J. (2022). Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity. TOXICOLOGICAL SCIENCES, 186(1), 58-69. doi:10.1093/toxsci/kfab144

DOI
10.1093/toxsci/kfab144
Journal article

2021

HLA Allele-Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction.

Jaruthamsophon, K., Thomson, P. J., Sukasem, C., Naisbitt, D. J., & Pirmohamed, M. (2021). HLA Allele-Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction.. Annual review of pharmacology and toxicology, 62, 509-529. doi:10.1146/annurev-pharmtox-052120-014115

DOI
10.1146/annurev-pharmtox-052120-014115
Journal article

Deciphering Adverse Drug Reactions: <i>In Vitro</i> Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01

Ogese, M. O., Lister, A., Gardner, J., Meng, X., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2021). Deciphering Adverse Drug Reactions: <i>In Vitro</i> Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01. TOXICOLOGICAL SCIENCES, 183(1), 139-153. doi:10.1093/toxsci/kfab084

DOI
10.1093/toxsci/kfab084
Journal article

Extracellular Vesicles from Human Plasma Show a Distinctive Proteome and miRNome Profile in Patients with Severe Cutaneous Adverse Reactions

Salinas-Jaramillo, O., Monroy-Arreola, A., Herrera-Norena, S., Guzman-Ortiz, A. L., Hernandez-Hernandez, A., Mendez-Flores, S., . . . Castrejon-Flores, J. L. (2021). Extracellular Vesicles from Human Plasma Show a Distinctive Proteome and miRNome Profile in Patients with Severe Cutaneous Adverse Reactions. CHEMICAL RESEARCH IN TOXICOLOGY, 34(7), 1738-1748. doi:10.1021/acs.chemrestox.1c00047

DOI
10.1021/acs.chemrestox.1c00047
Journal article

In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs

Naisbitt, D. (2021). In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs. Frontiers in Immunology. doi:10.3389/fimmu.2021.630530

DOI
10.3389/fimmu.2021.630530
Journal article

Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol

Setiabudi, W., Hungerford, D., Subramaniam, K., Vaselli, N. M., Shaw, V. E., Wilton, M., . . . French, N. (2021). Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol. BMJ Open, 11(3), e048317. doi:10.1136/bmjopen-2020-048317

DOI
10.1136/bmjopen-2020-048317
Journal article

Shedding Light on Drug-Induced Liver Injury: Activation of T Cells From Drug Naive Human Donors With Tolvaptan and a Hydroxybutyric Acid Metabolite

Hammond, S., Gibson, A., Jaruthamsophon, K., Roth, S., Mosedale, M., & Naisbitt, D. J. (2021). Shedding Light on Drug-Induced Liver Injury: Activation of T Cells From Drug Naive Human Donors With Tolvaptan and a Hydroxybutyric Acid Metabolite. TOXICOLOGICAL SCIENCES, 179(1), 95-107. doi:10.1093/toxsci/kfaa157

DOI
10.1093/toxsci/kfaa157
Journal article

Biopsy Pathology and Immunohistochemistry of a Case of Immune-Mediated Drug-Induced Liver Injury With Atabecestat

De Jonghe, S., Weinstock, D., Aligo, J., Washington, K., & Naisbitt, D. (2021). Biopsy Pathology and Immunohistochemistry of a Case of Immune-Mediated Drug-Induced Liver Injury With Atabecestat. HEPATOLOGY, 73(1), 452-455. doi:10.1002/hep.31403

DOI
10.1002/hep.31403
Journal article

2020

Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury

Waddington, J. C., Ali, S. -E., Penman, S. L., Whitaker, P., Hamlett, J., Chadwick, A., . . . Meng, X. (2020). Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 33(12), 2939-2943. doi:10.1021/acs.chemrestox.0c00400

DOI
10.1021/acs.chemrestox.0c00400
Journal article

Current perspective of the etiopathogenesis of delayed-type, and T-cell-mediated drug-related skin diseases

Vocanson, M., Naisbitt, D. J., & Nicolas, J. -F. (2020). Current perspective of the etiopathogenesis of delayed-type, and T-cell-mediated drug-related skin diseases. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(4), 1142-1144. doi:10.1016/j.jaci.2020.01.030

DOI
10.1016/j.jaci.2020.01.030
Journal article

Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA‐B*57:01 binding and T‐cell activation

Thomson, P. J., Illing, P. T., Farrell, J., Alhaidari, M., Bell, C. C., Berry, N., . . . Naisbitt, D. J. (2020). Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA‐B*57:01 binding and T‐cell activation. ALLERGY, 75(3), 636-647. doi:10.1111/all.14057

DOI
10.1111/all.14057
Journal article

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

Weaver, R. J., Blomme, E. A., Chadwick, A. E., Copple, I. M., Gerets, H. H. J., Goldring, C. E., . . . Park, B. K. (2020). Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models. NATURE REVIEWS DRUG DISCOVERY, 19(2), 131-148. doi:10.1038/s41573-019-0048-x

DOI
10.1038/s41573-019-0048-x
Journal article

T-Cell Activation by Low Molecular Weight Drugs and Factors That Influence Susceptibility to Drug Hypersensitivity

Hammond, S., Thomson, P. J., Ogese, M. O., & Naisbitt, D. J. (2020). T-Cell Activation by Low Molecular Weight Drugs and Factors That Influence Susceptibility to Drug Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 33(1), 77-94. doi:10.1021/acs.chemrestox.9b00327

DOI
10.1021/acs.chemrestox.9b00327
Journal article

2019

Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo

Tailor, A., Waddington, J. C., Hamlett, J., Maggs, J., Kafu, L., Farrell, J., . . . Meng, X. (2019). Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo. CHEMICAL RESEARCH IN TOXICOLOGY, 32(10), 2095-2106. doi:10.1021/acs.chemrestox.9b00282

DOI
10.1021/acs.chemrestox.9b00282
Journal article

Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01

Zhao, Q., Alhilali, K., Alzahrani, A., Almutairi, M., Amjad, J., Liu, H., . . . Naisbitt, D. J. (2019). Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01. Allergy, 74(8), 1533-1548. doi:10.1111/all.13769

DOI
10.1111/all.13769
Journal article

Characterization Of Amoxicillin- And Clavulanic Acid-Specific T-Cells In Patients With Amoxicillin-Clavulanic Acid Hypersensitivity Reactions

Ariza, A., Isabel Montanez, M., Ogese, M. O., Tailor, A., Fernandez, T. D., Torres, M. J., & Naisbitt, D. J. (2019). Characterization Of Amoxicillin- And Clavulanic Acid-Specific T-Cells In Patients With Amoxicillin-Clavulanic Acid Hypersensitivity Reactions. In JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Vol. 143 (pp. AB184). doi:10.1016/j.jaci.2018.12.563

DOI
10.1016/j.jaci.2018.12.563
Conference Paper

A child with a SCAR. A laboratory confirmed case of DRESS syndrome to piperacillin

Diacono, D., Mwenechanya, J., Mayell, S. J., & Naisbitt, D. J. (2019). A child with a SCAR. A laboratory confirmed case of DRESS syndrome to piperacillin. In CLINICAL AND EXPERIMENTAL ALLERGY Vol. 49 (pp. 1674-1675). Retrieved from https://www.webofscience.com/

Conference Paper

Beta-lactam protein binding leads to the presentation of novel MHC peptides, generating a potential immunogen for drug-hypersensitive reactions

Waddington, J., Meng, X., Illing, P., Tailor, A., Jenkins, R., Purcell, A., . . . Park, B. (2019). Beta-lactam protein binding leads to the presentation of novel MHC peptides, generating a potential immunogen for drug-hypersensitive reactions. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 176 (pp. 3004-3005). Retrieved from https://www.webofscience.com/

Conference Paper

Characterization of amoxicillin- and clavulanic acid-specific T-cells in patients with amoxicillin-clavulanic acid hypersensitivity reactions

Ariza Veguillas, A., Salas, M., Ogese, M. O., Montanez, M. I., Fernandez, T., Mayorga, C., . . . Naisbitt, D. J. (2019). Characterization of amoxicillin- and clavulanic acid-specific T-cells in patients with amoxicillin-clavulanic acid hypersensitivity reactions. In ALLERGY Vol. 74 (pp. 84-85). Retrieved from https://www.webofscience.com/

Conference Paper

2018

HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors

Usui, T., Tailor, A., Faulkner, L., Meng, X., Farrell, J., Daly, A. K., . . . Naisbitt, D. J. (2018). HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 31(10), 1022-1024. doi:10.1021/acs.chemrestox.8b00163

DOI
10.1021/acs.chemrestox.8b00163
Journal article

Mechanisms leading to T-cell activation in drug hypersensitivity

Meng, X., Yerly, D., & Naisbitt, D. J. (2018). Mechanisms leading to T-cell activation in drug hypersensitivity. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 18(4), 317-324. doi:10.1097/ACI.0000000000000458

DOI
10.1097/ACI.0000000000000458
Journal article

Up-Regulation of T-Cell Activation MicroRNAs in Drug-Specific CD4(+) T-Cells from Hypersensitive Patients

Monroy-Arreola, A., Duran-Figueroa, N. V., Mendez-Flores, S., Dominguez-Cherit, J., Watkinson, J., Badillo-Corona, J. A., . . . Castrejon-Flores, J. L. (2018). Up-Regulation of T-Cell Activation MicroRNAs in Drug-Specific CD4<SUP>+</SUP> T-Cells from Hypersensitive Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 31(6), 454-461. doi:10.1021/acs.chemrestox.7b00330

DOI
10.1021/acs.chemrestox.7b00330
Journal article

Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity

Usui, T., Faulkner, L., Farrell, J., French, N. S., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2018). Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity. CHEMICAL RESEARCH IN TOXICOLOGY, 31(3), 165-167. doi:10.1021/acs.chemrestox.8b00030

DOI
10.1021/acs.chemrestox.8b00030
Journal article

Implications of HLA-allele associations for the study of type IV drug hypersensitivity reactions

Sullivan, A., Watkinson, J., Waddington, J., Park, B. K., & Naisbitt, D. J. (2018). Implications of HLA-allele associations for the study of type IV drug hypersensitivity reactions. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 14(3), 261-274. doi:10.1080/17425255.2018.1441285

DOI
10.1080/17425255.2018.1441285
Journal article

Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017)

Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2018). Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1952. doi:10.4049/jimmunol.1800020

DOI
10.4049/jimmunol.1800020
Journal article

The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017)

Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2018). The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1951. doi:10.4049/jimmunol.1800019

DOI
10.4049/jimmunol.1800019
Journal article

Immune Mechanisms in Drug-Induced Liver Injury

Jaeschke, H., & Naisbitt, D. J. (2018). Immune Mechanisms in Drug-Induced Liver Injury. In DRUG-INDUCED LIVER TOXICITY (pp. 511-531). doi:10.1007/978-1-4939-7677-5_25

DOI
10.1007/978-1-4939-7677-5_25
Chapter

2017

Dapsone and Nitroso Dapsone Activation of Naive T-Cells from Healthy Donors

Alzahrani, A., Ogese, M., Meng, X., Waddington, J. C., Tailor, A., Farrell, J., . . . Naisbitt, D. (2017). Dapsone and Nitroso Dapsone Activation of Naive T-Cells from Healthy Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2174-2186. doi:10.1021/acs.chemrestox.7b00263

DOI
10.1021/acs.chemrestox.7b00263
Journal article

Assessment of anti-piperacillin IgG binding to structurally-related drug protein adducts

Park, B. K., & Naisbitt, D. (n.d.). Assessment of anti-piperacillin IgG binding to structurally-related drug protein adducts. Chemical Research in Toxicology.

Journal article

Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development

Goldring, C., Weaver, R., Kramer, B., Klingmueller, U., Oppelt, A., Van der Water, B., . . . Park, B. K. (2017). Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development. In COMPREHENSIVE MEDICINAL CHEMISTRY III, VOL 4: EXPERIMENTAL ADME AND TOXICOLOGY (pp. 217-238). doi:10.1016/B978-0-12-409547-2.12384-4

DOI
10.1016/B978-0-12-409547-2.12384-4
Chapter

Trimethoprim-induced aseptic meningism

Lochlainn, M. N., Gooi, H. C., Ogese, M. O., Naisbitt, D. J., & Jafar-Mohammadi, B. (2017). Trimethoprim-induced aseptic meningism. BRITISH JOURNAL OF HOSPITAL MEDICINE, 78(2), 108-109. doi:10.12968/hmed.2017.78.2.108

DOI
10.12968/hmed.2017.78.2.108
Journal article

Drug-specific CD4<SUP>+</SUP> T-cell immune responses are responsible for antituberculosis drug-induced maculopapular exanthema and drug reaction with eosinophilia and systemic symptoms syndrome

Ye, Y. -M., Hur, G. -Y., Kim, S. -H., Ban, G. -Y., Jee, Y. -K., Naisbitt, D. J., . . . Kim, S. -H. (2017). Drug-specific CD4<SUP>+</SUP> T-cell immune responses are responsible for antituberculosis drug-induced maculopapular exanthema and drug reaction with eosinophilia and systemic symptoms syndrome. BRITISH JOURNAL OF DERMATOLOGY, 176(2), 378-386. doi:10.1111/bjd.14839

DOI
10.1111/bjd.14839
Journal article

Human leukocyte antigen and idiosyncratic adverse drug reactions

Usui, T., & Naisbitt, D. J. (2017). Human leukocyte antigen and idiosyncratic adverse drug reactions. DRUG METABOLISM AND PHARMACOKINETICS, 32(1), 21-30. doi:10.1016/j.dmpk.2016.11.003

DOI
10.1016/j.dmpk.2016.11.003
Journal article

Temozolomide-induced drug rash with eosinophilia and systemic symptoms with positive lymphocyte transformation test

Poyner, E., Naisbitt, D. J., Farrell, J., Nagarajan, S., Ellis, R., & Fatah, S. (2017). Temozolomide-induced drug rash with eosinophilia and systemic symptoms with positive lymphocyte transformation test. In BRITISH JOURNAL OF DERMATOLOGY Vol. 177 (pp. 27). Retrieved from https://www.webofscience.com/

Conference Paper

2016

No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with <i>HLA</i>-<i>DRB1</i>*07:01-Restricted Lapatinib-Induced Liver Injury

Faulkner, L., Meng, X., Naisbitt, D. J., Spraggs, C. F., & Park, B. K. (2016). No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with <i>HLA</i>-<i>DRB1</i>*07:01-Restricted Lapatinib-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 29(12), 2111-2113. doi:10.1021/acs.chemrestox.6b00400

DOI
10.1021/acs.chemrestox.6b00400
Journal article

Effect of Repeated Daily Dosing with 2,4-Dinitrochlorobenzene on Glutathione Biosynthesis and Nrf2 Activation in Reconstructed Human Epidermis

Spriggs, S., Sheffield, D., Olayanju, A., Kitteringham, N. R., Naisbitt, D. J., & Aleksic, M. (2016). Effect of Repeated Daily Dosing with 2,4-Dinitrochlorobenzene on Glutathione Biosynthesis and Nrf2 Activation in Reconstructed Human Epidermis. TOXICOLOGICAL SCIENCES, 154(1), 5-15. doi:10.1093/toxsci/kfw140

DOI
10.1093/toxsci/kfw140
Journal article

2015

The chemical, genetic and immunological basis of idiosyncratic drug-induced liver injury

Tailor, A., Faulkner, L., Naisbitt, D. J., & Park, B. K. (2015). The chemical, genetic and immunological basis of idiosyncratic drug-induced liver injury. HUMAN & EXPERIMENTAL TOXICOLOGY, 34(12), 1310-1317. doi:10.1177/0960327115606529

DOI
10.1177/0960327115606529
Journal article

Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation

Naisbitt, D., Yang, E. L., Alhaidari, M., Berry, N., Lawrenson, A. S., Farrell, J., . . . Park, B. (2015). Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation. AIDS, 29(18), 2385-2395. doi:10.1097/QAD.0000000000000867

DOI
10.1097/QAD.0000000000000867
Journal article

Cutaneous immunopathology of long-standing complex regional pain syndrome

Osborne, S., Farrell, J., Dearman, R. J., MacIver, K., Naisbitt, D., Moots, R., . . . Goebel, A. (2015). Cutaneous immunopathology of long-standing complex regional pain syndrome. European Journal of Pain, 19(10), 1516-1526. doi:10.1002/ejp.685

DOI
10.1002/ejp.685
Journal article

<i>In Vitro</i> Priming of Naive T-cells with <i>p</i>-Phenylenediamine and Bandrowski's Base

Gibson, A., Kim, S. -H., Faulkner, L., Evely, J., Pirmohamed, M., Park, K. B., & Naisbitt, D. J. (2015). <i>In Vitro</i> Priming of Naive T-cells with <i>p</i>-Phenylenediamine and Bandrowski's Base. CHEMICAL RESEARCH IN TOXICOLOGY, 28(10), 2069-2077. doi:10.1021/acs.chemrestox.5b00294

DOI
10.1021/acs.chemrestox.5b00294
Journal article

Glutathione metabolism in the HaCaT cell line as a model for the detoxification of the model sensitisers 2,4-dinitrohalobenzenes in human skin

Jacquoilleot, S., Sheffield, D., Olayanju, A., Sison-Young, R., Kitteringham, N. R., Naisbitt, D. J., & Aleksic, M. (2015). Glutathione metabolism in the HaCaT cell line as a model for the detoxification of the model sensitisers 2,4-dinitrohalobenzenes in human skin. TOXICOLOGY LETTERS, 237(1), 11-20. doi:10.1016/j.toxlet.2015.05.016

DOI
10.1016/j.toxlet.2015.05.016
Journal article

HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis

Ogese, M. O., Saide, K., Faulkner, L., Whitaker, P., Peckham, D., Alfirevic, A., . . . Naisbitt, D. J. (2015). HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis. CLINICAL AND EXPERIMENTAL ALLERGY, 45(8), 1305-1316. doi:10.1111/cea.12546

DOI
10.1111/cea.12546
Journal article

Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy

Wheatley, L. M., Plaut, M., Schwaninger, J. M., Banerji, A., Castells, M., Finkelman, F. D., . . . Trepanier, L. A. (2015). Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy. In JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Vol. 136 (pp. 262-+). doi:10.1016/j.jaci.2015.05.027

DOI
10.1016/j.jaci.2015.05.027
Conference Paper

Activation of flucloxacillin-specific CD8+ T-cells with the potential to promote hepatocyte cytotoxicity in a mouse model

Nattrass, R., Faulkner, L., Vocanson, M., Antoine, D., Kipar, A., Kenna, G., . . . Naisbitt, D. (2015). Activation of flucloxacillin-specific CD8+ T-cells with the potential to promote hepatocyte cytotoxicity in a mouse model. Toxicological Sciences, 146(1), 146-156. doi:10.1093/toxsci/kfv077

DOI
10.1093/toxsci/kfv077
Journal article

Towards the development of mechanism-based biomarkers to diagnose drug hypersensitivity

Duran-Figueroa, N., Badillo-Corona, J. A., Naisbitt, D. J., & Castrejon-Flores, J. L. (2015). Towards the development of mechanism-based biomarkers to diagnose drug hypersensitivity. TOXICOLOGY RESEARCH, 4(4), 777-795. doi:10.1039/c4tx00238e

DOI
10.1039/c4tx00238e
Journal article

Negative regulation by PD-L1 during drug-specific priming of IL-22-secreting T cells and the influence of PD-1 on effector T cell function

Gibson, A., Ogese, M., Sullivan, A., Wang, E., Saide, K., Whitaker, P., . . . Naisbitt, D. J. (2015). Negative regulation by PD-L1 during drug-specific priming of IL-22-secreting T cells and the influence of PD-1 on effector T cell function. Journal of Immunology, 192(06), 2611-2621. doi:10.4049/jimmunol.1302720

DOI
10.4049/jimmunol.1302720
Journal article

Are drug metabolites able to cause T-cell-mediated hypersensitivity reactions?

Sullivan, A., Gibson, A., Park, B. K., & Naisbitt, D. J. (2015). Are drug metabolites able to cause T-cell-mediated hypersensitivity reactions?. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 11(3), 357-368. doi:10.1517/17425255.2015.992780

DOI
10.1517/17425255.2015.992780
Journal article

Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin

Meng, X., Maggs, J. L., Usui, T., Whitaker, P., French, N. S., Naisbitt, D. J., & Park, B. K. (2015). Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin. Chemical Research in Toxicology, 28(1), 51-58. doi:10.1021/tx500285k

DOI
10.1021/tx500285k
Journal article

Characterization of Peroxidases Expressed in Human AntigenPresenting Cells and Analysis of the Covalent Binding of NitrosoSulfamethoxazole to Myeloperoxidase

Ogese, M. O., Jenkins,, R. E., Maggs, J. L., Meng, X., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2015). Characterization of Peroxidases Expressed in Human AntigenPresenting Cells and Analysis of the Covalent Binding of NitrosoSulfamethoxazole to Myeloperoxidase. Chemical Research in Toxicology, 28(1), 144-154. doi:10.1021/tx500458k

DOI
10.1021/tx500458k
Journal article

CD4+and CD8+T-cells isolated from blood and skin of patients with β-lactam hypersensitivity secrete Interleukin-22, but not Interleukin-17

Sullivan, A., Faulkner, L., Farrell, J., Whitaker, P., Peckham, D., Park, B. K., & Naisbitt, D. (2015). CD4+and CD8+T-cells isolated from blood and skin of patients with β-lactam hypersensitivity secrete Interleukin-22, but not Interleukin-17. In ALLERGY Vol. 70 (pp. 25-26). Retrieved from https://www.webofscience.com/

Conference Paper

Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses

Gibson, A., Faulkner, L., Ogese, M., Lichtenfels, M., Esser, P., Martin, S., . . . Naisbitt, D. (2015). Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses. In ALLERGY Vol. 70 (pp. 26). Retrieved from https://www.webofscience.com/

Conference Paper

2014

Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial

Middleton, G., Silcocks, P., Cox, T. F., Valle, J., Wadsley, J., Propper, D., . . . Neoptolemos, J. P. (2014). Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial. The Lancet Oncology, 15(8), 829-840. doi:10.1016/S1470-2045(14)70236-0

DOI
10.1016/S1470-2045(14)70236-0
Journal article

Abacavir forms novel cross-linking abacavir protein adducts in patients

Meng, X., Lawrenson, A. S., Berry, N. G., Maggs, J. L., French, N. S., Back, D. J., . . . Park, B. K. (2014). Abacavir forms novel cross-linking abacavir protein adducts in patients. Chemical Research in Toxicology, 27(04), 524-535. doi:10.1021/tx400406p

DOI
10.1021/tx400406p
Journal article

HLA restriction of carbamazepine-specific T-cell clones from an HLA-A*31:01-positive hypersensitive patient

Lichtenfels, M., Farrell, J., Ogese, M. O., Bell, C. C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). HLA restriction of carbamazepine-specific T-cell clones from an HLA-A*31:01-positive hypersensitive patient. Chemical Research in Toxicology, 27(02), 175-177. doi:10.1021/tx400460w

DOI
10.1021/tx400460w
Journal article

In Vitro Diagnosis of Delayed-type Drug Hypersensitivity Mechanistic Aspects and Unmet Needs

Naisbitt, D. J., Nattrass, R. G., & Ogese, M. O. (2014). In Vitro Diagnosis of Delayed-type Drug Hypersensitivity Mechanistic Aspects and Unmet Needs. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 34(3), 691-+. doi:10.1016/j.iac.2014.04.009

DOI
10.1016/j.iac.2014.04.009
Journal article

T cell responses to drugs and drug metabolites.

Earnshaw, C. J., Pecaric-Petkovic, T., Park, B. K., & Naisbitt, D. J. (2014). T cell responses to drugs and drug metabolites.. Experientia supplementum (2012), 104, 137-163. doi:10.1007/978-3-0348-0726-5_10

DOI
10.1007/978-3-0348-0726-5_10
Journal article

The importance of hapten - protein complex formation in the development of drug allergy

Faulkner, L., Meng, X., Park, B. K., & Naisbitt, D. J. (2014). The importance of hapten - protein complex formation in the development of drug allergy. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 14(4), 293-300. doi:10.1097/ACI.0000000000000078

DOI
10.1097/ACI.0000000000000078
Journal article

2013

The Generation, Detection, and Effects of Reactive Drug Metabolites

Stachulski, A. V., Baillie, T. A., Park, B. K., Obach, R. S., Dalvie, D. K., Williams, D. P., . . . Lennard, M. S. (2013). The Generation, Detection, and Effects of Reactive Drug Metabolites. MEDICINAL RESEARCH REVIEWS, 33(5), 985-1080. doi:10.1002/med.21273

DOI
10.1002/med.21273
Journal article

Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFNβ interact with the endogenous cytokine and activate complement

Sethu, S., Govindappa, K., Quinn, P., Wadhwa, M., Stebbings, R., Boggild, M., . . . Sathish, J. (2013). Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFNβ interact with the endogenous cytokine and activate complement. CLINICAL IMMUNOLOGY, 148(2), 177-185. doi:10.1016/j.clim.2013.05.008

DOI
10.1016/j.clim.2013.05.008
Journal article

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., . . . Hengstler, J. G. (2013). Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. ARCHIVES OF TOXICOLOGY, 87(8), 1315-1530. doi:10.1007/s00204-013-1078-5

DOI
10.1007/s00204-013-1078-5
Journal article

Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells

Bell, C. C., Castelazo, A. S., Yang, E. L., Maggs, J. L., Jeankins, R. E., Tugwood, J., . . . Park, B. K. (2013). Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells. CHEMICAL RESEARCH IN TOXICOLOGY, 26(7), 1064-1072. doi:10.1021/tx400041v

DOI
10.1021/tx400041v
Journal article

β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis

Jenkins, R. E., Yaseen, F. S., Monshi, M. M., Whitaker, P., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2013). β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis. CHEMICAL RESEARCH IN TOXICOLOGY, 26(6), 963-975. doi:10.1021/tx400124m

DOI
10.1021/tx400124m
Journal article

T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms

Bell, C. C., Faulkner, L., Martinsson, K., Farrell, J., Alfirevic, A., Tugwood, J., . . . Park, B. K. (2013). T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms. CHEMICAL RESEARCH IN TOXICOLOGY, 26(5), 759-766. doi:10.1021/tx400060p

DOI
10.1021/tx400060p
Journal article

Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients

Meng, X., Howarth, A., Earnshaw, C. J., Jenkins, R. E., French, N. S., Back, D. J., . . . Park, B. K. (2013). Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 26(4), 575-583. doi:10.1021/tx4000107

DOI
10.1021/tx4000107
Journal article

Challenges and approaches for the development of safer immunomodulatory biologics

Sathish, J. G., Sethu, S., Bielsky, M. -C., de Haan, L., French, N. S., Govindappa, K., . . . Park, B. K. (2013). Challenges and approaches for the development of safer immunomodulatory biologics. NATURE REVIEWS DRUG DISCOVERY, 12(4), 306-324. doi:10.1038/nrd3974

DOI
10.1038/nrd3974
Journal article

Human Leukocyte Antigen (HLA)-B<SUP>☆</SUP>57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury

Monshi, M. M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2013). Human Leukocyte Antigen (HLA)-B<SUP>☆</SUP>57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury. HEPATOLOGY, 57(2), 727-739. doi:10.1002/hep.26077

DOI
10.1002/hep.26077
Journal article

Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives

Farrell, J., Lichtenfels, M., Sullivan, A., Elliott, E. C., Alfirevic, A., Stachulski, A. V., . . . Park, B. K. (2013). Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132(2), 493-495. doi:10.1016/j.jaci.2013.02.045

DOI
10.1016/j.jaci.2013.02.045
Journal article

Characterization of the B cell response in piperacillin hypersensitive patients with cystic fibrosis

Amali, M., Sullivan, A., Yaseen, F. S., Farrell, J., Faulkner, L., Whitaker, P., . . . Naisbitt, D. J. (2013). Characterization of the B cell response in piperacillin hypersensitive patients with cystic fibrosis. In IMMUNOLOGY Vol. 140 (pp. 192). Retrieved from https://www.webofscience.com/

Conference Paper

Definition of the mechanistic basis immunological drug reactions using human cells

Naisbitt, D. J. (2013). Definition of the mechanistic basis immunological drug reactions using human cells. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 246. Retrieved from https://www.webofscience.com/

Conference Paper

Idiosyncratic Adverse Drug Reactions: Current Concepts

Uetrecht, J., & Naisbitt, D. J. (2013). Idiosyncratic Adverse Drug Reactions: Current Concepts. PHARMACOLOGICAL REVIEWS, 65(2), 779-808. doi:10.1124/pr.113.007450

DOI
10.1124/pr.113.007450
Journal article

Negative regulation by PD-L1 during drug-specific priming of IL-22 secreting T-cells and the influence of PD-1 on effector T-cell function

Ogese, M. O., Gibson, A., Sullivan, A., Wang, E., Saide, K., Whitaker, P., . . . Naisbitt, D. (2013). Negative regulation by PD-L1 during drug-specific priming of IL-22 secreting T-cells and the influence of PD-1 on effector T-cell function. In IMMUNOLOGY Vol. 140 (pp. 206). Retrieved from https://www.webofscience.com/

Conference Paper

2012

Explanation for <i>HLA</i>-<i>B</i>*<i>57</i>:<i>01</i>-linked immune-mediated abacavir-induced hypersensitivity

Alfirevic, A., Park, B. K., Pirmohamed, M., & Naisbitt, D. J. (2012). Explanation for <i>HLA</i>-<i>B</i>*<i>57</i>:<i>01</i>-linked immune-mediated abacavir-induced hypersensitivity. PHARMACOGENOMICS, 13(14), 1567-1569. doi:10.2217/PGS.12.146

DOI
10.2217/PGS.12.146
Journal article

IL-8 Release from Human Neutrophils Cultured with Pro-Haptenic Chemical Sensitizers

Kiorpelidou, E., Foster, B., Farrell, J., Ogese, M. O., Faulkner, L., Goldring, C. E., . . . Naisbitt, D. J. (2012). IL-8 Release from Human Neutrophils Cultured with Pro-Haptenic Chemical Sensitizers. CHEMICAL RESEARCH IN TOXICOLOGY, 25(10), 2054-2056. doi:10.1021/tx300350s

DOI
10.1021/tx300350s
Journal article

Nonimmediate β-lactam reactions in patients with cystic fibrosis

Whitaker, P., Naisbitt, D., & Peckham, D. (2012). Nonimmediate β-lactam reactions in patients with cystic fibrosis. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 12(4), 369-375. doi:10.1097/ACI.0b013e328355b849

DOI
10.1097/ACI.0b013e328355b849
Journal article

<i>In silico</i> analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers

Alfirevic, A., Gonzalez-Galarza, F., Bell, C., Martinsson, K., Platt, V., Bretland, G., . . . Pirmohamed, M. (2012). <i>In silico</i> analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers. GENOME MEDICINE, 4. doi:10.1186/gm350

DOI
10.1186/gm350
Journal article

Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis

El-Ghaiesh, S., Monshi, M. M., Whitaker, P., Jenkins, R., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 341(3), 597-610. doi:10.1124/jpet.111.190900

DOI
10.1124/jpet.111.190900
Journal article

The Development of <i>In Vitro</i> Culture Methods to Characterize Primary T-Cell Responses to Drugs

Faulkner, L., Martinsson, K., Santoyo-Castelazo, A., Cederbrant, K., Schuppe-Koistinen, I., Powell, H., . . . Park, B. K. (2012). The Development of <i>In Vitro</i> Culture Methods to Characterize Primary T-Cell Responses to Drugs. TOXICOLOGICAL SCIENCES, 127(1), 150-158. doi:10.1093/toxsci/kfs080

DOI
10.1093/toxsci/kfs080
Journal article

Characterisation of antidrug antibodies (ADA) against therapeutic interferon beta

Govindappa, K., Sethu, S., Wadwa, M., Stebbings, R., Kimber, I., Naisbitt, D. J., . . . Sathish, J. G. (2012). Characterisation of antidrug antibodies (ADA) against therapeutic interferon beta. In IMMUNOLOGY Vol. 137 (pp. 655-656). Retrieved from https://www.webofscience.com/

Conference Paper

Characterisation of durg antigen-specific T-cell responses in multi-allergic patients with cystic fibrosis

Yaseen, F., Monshi, M., Farrell, J., Whitaker, P., Peckham, D., Pirmohamed, M., . . . Naisbitt, D. J. (2012). Characterisation of durg antigen-specific T-cell responses in multi-allergic patients with cystic fibrosis. J Allergy Clin Immunol.

Journal article

Characterization of B-cell resposnes in piperacillin allergic and tolerant patients

Sullivan, A., Amali, M., Faulkner, L., Whitaker, P., Peckham, D., Pirmohamed, M., . . . Naisbitt, D. J. (2012). Characterization of B-cell resposnes in piperacillin allergic and tolerant patients. Allergy.

Journal article

Characterization of drug presentation to T-lymphocytes using clones isolated from piperacillin hypersensitive human patients.

El-Ghaiesh, S., Monshi, M., Whitaker, P., Meng, X., Jenkins, R., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of drug presentation to T-lymphocytes using clones isolated from piperacillin hypersensitive human patients.. J Pharmacol Exp Ther, 341, 597-610.

Journal article

Clinical picture of drug hypersensitivity reactions

Bell, C., Naisbitt, D. J., & Park, B. K. (2012). Clinical picture of drug hypersensitivity reactions. ALTA.

Journal article

Development of in vitro assays to characterize primary T cell responses to drugs

Faulkner, J., Martinsson, K., Castelazo, A. S., Cederbrant, K., Schuppe-Koistinen, I., Powell, H., . . . Park, B. K. (2012). Development of in vitro assays to characterize primary T cell responses to drugs. Toxicological Sciences, 127, 150-158.

Journal article

HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury

Monshi, M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2012). HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury. Hepatology.

Journal article

IL-8 secretion from primary neutrophils cultured with haptenic and pro-haptenic chemical sensitizers

Kiorpelidou, E., Foster, B., Naisbitt, D. J., & Park, B. K. (2012). IL-8 secretion from primary neutrophils cultured with haptenic and pro-haptenic chemical sensitizers. Che Res Toxicol.

Journal article

Multiple Drug Hypersensitivity (MDH): normal Treg cell function but enhanced in vivo activation of drug-specific T cells.

Daubner, B., Groux-Keller, M., Hausmann, O., Kawabata, T., Naisbitt, D. J., Park, B. K., . . . Pichler, W. J. (2012). Multiple Drug Hypersensitivity (MDH): normal Treg cell function but enhanced in vivo activation of drug-specific T cells.. Allergy, 187, 1398-1405.

Journal article

Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells

Daubner, B., Groux-Keller, M., Hausmann, O. V., Kawabata, T., Naisbitt, D. J., Park, B. K., . . . Pichler, W. J. (2012). Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells. ALLERGY, 67(1), 58-66. doi:10.1111/j.1398-9995.2011.02720.x

DOI
10.1111/j.1398-9995.2011.02720.x
Journal article

Perspectives to predict idiosyncratic drug-induced liver injury in vitro.

Gibson, A., Eakins, R., Goldring, C. E. P., Naisbitt, D. J., Rowe, C., & Park, B. K. (2012). Perspectives to predict idiosyncratic drug-induced liver injury in vitro.. Drug Metabolism Reviews.

Journal article

T-cell responses to drugs and drug metabolites

Earnshaw, C., Park, B. K., & Naisbitt, D. J. (2012). T-cell responses to drugs and drug metabolites. In S. F. Martin (Ed.), T Lymphocytes as Tools in Chemical and Drug Allergy (pp. 180-193). San Fransisco: Springer.

Chapter

T-cell responses to flucloxacillin protein adducts in a mouse model of immunogenicity

Nattrass, R., Jenkins, R., Faulkner, L., Yaseen, F., Park, B. K., & Naisbitt, D. J. (2012). T-cell responses to flucloxacillin protein adducts in a mouse model of immunogenicity. Tox Sci.

Journal article

T-cell responses to halogenated carbamazepine

Farrell, J., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2012). T-cell responses to halogenated carbamazepine. Chem Res Toxicol.

Journal article

The generation, detection and effects of reactive drug metabolites. Med Res Reviews.

Baillie, T. A., Park, B. K., Obach, R. S., Dalvie, D. K., Williams, D. P., Srivastava, A., . . . Stachulski, A. V. (2012). The generation, detection and effects of reactive drug metabolites. Med Res Reviews.. Med Res Reviews.

Journal article

The use of anti-programmed death ligand antibodies to enhance in vitro antigen-specific T-cell priming

Gibson, A., Faulkner, L., Park, B. K., & Naisbitt, D. J. (2012). The use of anti-programmed death ligand antibodies to enhance in vitro antigen-specific T-cell priming. Tox Sci.

Journal article

2011

Establishment of an HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions

Bell, C., Martinsson, K., Faulkner, L., Alfirevic, A., French, N., Tugwood, J., . . . Park, B. K. (2011). Establishment of an HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions. TOXICOLOGY, 290(2-3), 132-133. doi:10.1016/j.tox.2011.09.057

DOI
10.1016/j.tox.2011.09.057
Journal article

Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients

Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 338(3), 841-849. doi:10.1124/jpet.111.183871

DOI
10.1124/jpet.111.183871
Journal article

Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients

Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. Journal of Pharmacology and Experimental Therapeutics, 338(3), 841-849. doi:10.1124/jpet.111.183871

DOI
10.1124/jpet.111.183871
Journal article

Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis

Whitaker, P., Meng, X., Lavergne, S. N., El-Ghaiesh, S., Monshi, M., Earnshaw, C., . . . Park, B. K. (2011). Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis. JOURNAL OF IMMUNOLOGY, 187(1), 200-211. doi:10.4049/jimmunol.1100647

DOI
10.4049/jimmunol.1100647
Journal article

Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity

Park, B. K., Laverty, H., Srivastava, A., Antoine, D. J., Naisbitt, D., & Williams, D. P. (2011). Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity. CHEMICO-BIOLOGICAL INTERACTIONS, 192(1-2), 30-36. doi:10.1016/j.cbi.2010.09.011

DOI
10.1016/j.cbi.2010.09.011
Journal article

Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways

El-Ghaiesh, S., Sanderson, J. P., Farrell, J., Lavergne, S. N., Syn, W. -K., Pirmohamed, M., . . . Naisbitt, D. J. (2011). Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways. CHEMICAL RESEARCH IN TOXICOLOGY, 24(6), 791-793. doi:10.1021/tx2001256

DOI
10.1021/tx2001256
Journal article

Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis

Elsheikh, A., Castrejon, L., Lavergne, S. N., Whitaker, P., Monshi, M., Callan, H., . . . Naisbitt, D. J. (2011). Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis. Journal of Allergy and Clinical Immunology, 127(6), 1543-1551.e3. doi:10.1016/j.jaci.2010.12.1119

DOI
10.1016/j.jaci.2010.12.1119
Journal article

Managing the challenge of chemically reactive metabolites in drug development

Park, B. K., Boobis, A., Clarke, S., Goldring, C. E. P., Jones, D., Kenna, J. G., . . . Baillie, T. A. (2011). Managing the challenge of chemically reactive metabolites in drug development. NATURE REVIEWS DRUG DISCOVERY, 10(4), 292-306. doi:10.1038/nrd3408

DOI
10.1038/nrd3408
Journal article

Multiple drug hypersensitivity: role of T regulatory cells

Daubner, B., Groux-Keller, M., Kawabata, T., Naisbitt, D. J., Park, K. B., Thomas, W., . . . Pichler, W. J. (2011). Multiple drug hypersensitivity: role of T regulatory cells. In JOURNAL OF IMMUNOLOGY Vol. 186. Retrieved from https://www.webofscience.com/

Conference Paper

Immune pathomechanism of drug hypersensitivity reactions

Pichler, W. J., Naisbitt, D. J., & Park, B. K. (2011). Immune pathomechanism of drug hypersensitivity reactions. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(3), S74-S81. doi:10.1016/j.jaci.2010.11.048

DOI
10.1016/j.jaci.2010.11.048
Journal article

Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury

El-Ghaiesh, S., Sanderson, J. P., Farrell, J., Lavergne, S. N., Syn, W. -K., Pirmohamed, M., . . . Naisbitt, D. J. (2011). Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 128(3), 680-U368. doi:10.1016/j.jaci.2011.04.031

DOI
10.1016/j.jaci.2011.04.031
Journal article

Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury.

El-Ghaiesh, S., Sanderson, J. P., Farrell, J., Lavergne, S. N., Syn, W. K., Pirmohamed, M., . . . Naisbitt, D. J. (2011). Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury.. J Allergy Clin Immunol., 128, 680-683.

Journal article

Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity.

Park, B. K., Laverty, H., Srivastava, A., Antoine, D. J., Naisbitt, D., & Williams, D. P. (2011). Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity.. Chem Biol Interact., 192, 30-36.

Journal article

Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis

Elsheikh, A., Castrejon, L., Lavergne, S. N., Whitaker, P., Monshi, M., Callan, H., . . . Naisbitt, D. J. (2011). Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(6), 1543-U348. doi:10.1016/j.jaci.2010.12.1119

DOI
10.1016/j.jaci.2010.12.1119
Journal article

Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis.

Elsheikh, A., Castrejon, L., Lavergne, S. N., Whitaker, P., Monshi, M., Callan, H., . . . Naisbitt, D. J. (2011). Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis.. The Journal of allergy and clinical immunology, 127(6), 1543-51.e3. doi:10.1016/j.jaci.2010.12.1119

DOI
10.1016/j.jaci.2010.12.1119
Journal article

Immune pathomechanism of drug hypersensitivity reactions

Pichler, W. J., Naisbitt, D. J., & Park, B. K. (2011). Immune pathomechanism of drug hypersensitivity reactions. Journal of Allergy and Clinical Immunology, 127(S3), S74-S81.

Journal article

Managing the challenge of chemically reactive metabolites in drug development.

Park, B. K., Boobis, A., Clarke, S., Goldring, C. E., Jones, D., Kenna, J. G., . . . Baillie, T. A. (2011). Managing the challenge of chemically reactive metabolites in drug development.. Nat Rev Drug Discov., 10, 292-306.

Journal article

Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis.

Whitaker, P., Meng, X., Lavergne, S. N., El-Ghaiesh, S., Monshi, M., Earnshaw, C., . . . Park, B. K. (2011). Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis.. J Immunol., 187, 200-211.

Journal article

rimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways.

El-Ghaiesh, S., Sanderson, J. P., Farrell, J., Lavergne, S. N., Syn, W. K., Pirmohamed, M., . . . Naisbitt, D. J. (2011). rimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways.. Chem Res Toxicol., 24, 791-793.

Journal article

2010

Drug Antigenicity, Immunogenicity, and Costimulatory Signaling: Evidence for Formation of a Functional Antigen through Immune Cell Metabolism

Elsheikh, A., Lavergne, S. N., Castrejon, J. L., Farrell, J., Wang, H., Sathish, J., . . . Naisbitt, D. J. (2010). Drug Antigenicity, Immunogenicity, and Costimulatory Signaling: Evidence for Formation of a Functional Antigen through Immune Cell Metabolism. JOURNAL OF IMMUNOLOGY, 185(11), 6448-6460. doi:10.4049/jimmunol.1000889

DOI
10.4049/jimmunol.1000889
Journal article

Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer

Shaw, V. E., Naisbitt, D. J., Costello, E., Greenhalf, W., Park, B. K., Neoptolemos, J. P., & Middleton, G. W. (2010). Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer. EXPERT REVIEW OF VACCINES, 9(9), 1007-1016. doi:10.1586/ERV.10.92

DOI
10.1586/ERV.10.92
Journal article

Drug Metabolite-Specific Lymphocyte Responses in Sulfamethoxazole Allergic Patients with Cystic Fibrosis

Lavergne, S. N., Whitaker, P., Peckham, D., Conway, S., Park, B. K., & Naisbitt, D. J. (2010). Drug Metabolite-Specific Lymphocyte Responses in Sulfamethoxazole Allergic Patients with Cystic Fibrosis. CHEMICAL RESEARCH IN TOXICOLOGY, 23(6), 1009-1011. doi:10.1021/tx100151v

DOI
10.1021/tx100151v
Journal article

Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives

Castrejon, J. L., Lavergne, S. N., El-Sheikh, A., Farrell, J., Maggs, J. L., Sabbani, S., . . . Naisbitt, D. J. (2010). Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives. CHEMICAL RESEARCH IN TOXICOLOGY, 23(1), 184-192. doi:10.1021/tx900329b

DOI
10.1021/tx900329b
Journal article

ADVERSE REACTIONS TO COLISTIN IN CYSTIC FIBROSIS: DOSE-DEPENDENT TOXICITY OR IMMUNE-MEDIATED REACTIONS?

Lavergne, S. N., Whitaker, P., Peckham, D., Conway, S., Gooi, J., Park, B. K., & Naisbitt, D. J. (2010). ADVERSE REACTIONS TO COLISTIN IN CYSTIC FIBROSIS: DOSE-DEPENDENT TOXICITY OR IMMUNE-MEDIATED REACTIONS?. In PEDIATRIC PULMONOLOGY (pp. 377). Retrieved from https://www.webofscience.com/

Conference Paper

AN INSIGHT INTO CIRCULATING DRUG-SPECIFIC LYMPHOCYTES FROM CYSTIC FIBROSIS PATIENTS WITH A HISTORY OF DELAYED ALLERGIC REACTION TO ANTIBACTERIALS

Lavergne, S. N., Whitaker, P., Peckham, D., Conway, S., Gooi, J., Peckham, B. K., & Naisbitt, D. J. (2010). AN INSIGHT INTO CIRCULATING DRUG-SPECIFIC LYMPHOCYTES FROM CYSTIC FIBROSIS PATIENTS WITH A HISTORY OF DELAYED ALLERGIC REACTION TO ANTIBACTERIALS. In PEDIATRIC PULMONOLOGY (pp. 377). Retrieved from https://www.webofscience.com/

Conference Paper

Characterization of <i>p</i>-Phenylenediamine-Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein

Jenkinson, C., Jenkins, R. E., Aleksic, M., Pirmohamed, M., Naisbitt, D. J., & Park, B. K. (2010). Characterization of <i>p</i>-Phenylenediamine-Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130(3), 732-742. doi:10.1038/jid.2009.271

DOI
10.1038/jid.2009.271
Journal article

Characterization of piperacillin-specific T-cell clones from hypersensitive patients with cystic fibrosis

El-Ghaiesh, S., Monshi, M., Jenkins, R., Meng, X., French, N., Whitaker, P., . . . Naisbitt, D. (2010). Characterization of piperacillin-specific T-cell clones from hypersensitive patients with cystic fibrosis. In IMMUNOLOGY Vol. 131 (pp. 117). Retrieved from https://www.webofscience.com/

Conference Paper

Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer.

Shaw, V., Naisbitt, D. J., Costello, E., Greenhalf, W., Park, B. K., Neoptolemos, J. P., & Middleton, G. W. (2010). Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer.. Expert Reviews in Vaccines, 9, 1007-1016.

Journal article

DRUG HYPERSENSITIVITY

Naisbitt, D. J., Park, B. K., & Demoly, P. (2010). DRUG HYPERSENSITIVITY. In S. Holgate (Ed.), Allergy (pp. 200). London: Elsveier.

Chapter

Development of a neutrophil cell culture system to define the sensitizing potential of chemical allergens that acquire protein reactivity through metabolism

Kiorpelidou, E., Foster, B. J., Goldring, C., Naisbitt, D. J., & Park, K. (2010). Development of a neutrophil cell culture system to define the sensitizing potential of chemical allergens that acquire protein reactivity through metabolism. In IMMUNOLOGY Vol. 131 (pp. 171-172). Retrieved from https://www.webofscience.com/

Conference Paper

Drug antigenicity, immunogencitiy, and co-stimulatory signalling: evidence for formation of a functional antigen through immune cell metabolism

Elsheikh, A., Lavergne, S. N., Castrejon, J. L., Farrell, J., Wang, H., Sathish, J., . . . Naisbitt, D. J. (2010). Drug antigenicity, immunogencitiy, and co-stimulatory signalling: evidence for formation of a functional antigen through immune cell metabolism. Journal of Immunology, 185, 6448-6460. doi:10.4049/jimmunol.1000889

DOI
10.4049/jimmunol.1000889
Journal article

Drug-metabolite specific lymphocyte responses in sulfamethoxazole allergic patients with cystic fibrosis

Lavergne, S. N., Whitaker, P., Peckham, D., Conway, S., Park, B. K., & Naisbitt, D. J. (2010). Drug-metabolite specific lymphocyte responses in sulfamethoxazole allergic patients with cystic fibrosis. Chemical Research in Toxicology, 23, 1009-1011.

Journal article

Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole hypersensitive patients with cystic fibrosis

Elsheikh, A., Monshi, M., Castrejon, J., Lavergne, S., Whitaker, P., Pichler, W. J., . . . Naisbitt, D. J. (2010). Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole hypersensitive patients with cystic fibrosis. IMMUNOLOGY, 131, 145-146. Retrieved from https://www.webofscience.com/

Journal article

Establishment of a HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions

Bell, C., Martinsson, K., Faulkner, L., Alfirevic, A., French, N., Tugwood, J., . . . Park, B. K. (2010). Establishment of a HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions. In IMMUNOLOGY Vol. 131 (pp. 125). Retrieved from https://www.webofscience.com/

Conference Paper

Involvement of drug-specific CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T-cells in trimethoprim-mediated hepatitis

El-Ghaiesh, S., Lavergne, S., Farrell, J., Syn, W., Pirmohamed, M., Park, K., & Naisbitt, D. (2010). Involvement of drug-specific CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T-cells in trimethoprim-mediated hepatitis. In IMMUNOLOGY Vol. 131 (pp. 120). Retrieved from https://www.webofscience.com/

Conference Paper

Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in <i>p</i>-Phenylenediamine Allergic Patients and Tolerant Individuals

Coulter, E. M., Jenkinson, C., Farrell, J., Lavergne, S. N., Pease, C., White, A., . . . Naisbitt, D. J. (2010). Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in <i>p</i>-Phenylenediamine Allergic Patients and Tolerant Individuals. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130(1), 161-174. doi:10.1038/jid.2009.187

DOI
10.1038/jid.2009.187
Journal article

Stimulation of human T cells with sulfonamides and sulfonamide metabolites

Castrejon, J. L., Berry, N., El-Ghaiesh, S., Gerber, B., Pichler, W. J., Park, B. K., & Naisbitt, D. J. (2010). Stimulation of human T cells with sulfonamides and sulfonamide metabolites. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 125(2), 411-418. doi:10.1016/j.jaci.2009.10.031

DOI
10.1016/j.jaci.2009.10.031
Journal article

Stimulation of sulfamethoxazole and sulfamethoxazole metabolite specific T-cells in patients with cystic fibrosis

Elsheikh, A., Callan, H., Monshi, M., Lavergne, S., Castrejon, J., El-Ghaiesh, S., . . . Naisbitt, D. J. (2010). Stimulation of sulfamethoxazole and sulfamethoxazole metabolite specific T-cells in patients with cystic fibrosis. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 70 (pp. 297). Retrieved from https://www.webofscience.com/

Conference Paper

T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays

Martin, S. F., Esser, P. R., Schmucker, S., Dietz, L., Naisbitt, D. J., Park, B. K., . . . Sallusto, F. (2010). T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays. CELLULAR AND MOLECULAR LIFE SCIENCES, 67(24), 4171-4184. doi:10.1007/s00018-010-0495-3

DOI
10.1007/s00018-010-0495-3
Journal article

TeloVac trial translational studies: investigation of the immune response to GV1001

Shaw, V., Naisbitt, D., Costello, E., Farrell, J., Park, B. K., Neoptolemos, J., & Middleton, G. (2010). TeloVac trial translational studies: investigation of the immune response to GV1001. In IMMUNOLOGY Vol. 131 (pp. 164). Retrieved from https://www.webofscience.com/

Conference Paper

2009

"Danger" Conditions Increase Sulfamethoxazole-Protein Adduct Formation in Human Antigen-Presenting Cells

Lavergne, S. N., Wang, H., Callan, H. E., Park, B. K., & Naisbitt, D. J. (2009). "Danger" Conditions Increase Sulfamethoxazole-Protein Adduct Formation in Human Antigen-Presenting Cells. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 331(2), 372-381. doi:10.1124/jpet.109.155374

DOI
10.1124/jpet.109.155374
Journal article

The role of metabolism in T-cell mediated drug hypersensitivity reactions

Naisbitt, D. (2009). The role of metabolism in T-cell mediated drug hypersensitivity reactions. TOXICOLOGY LETTERS, 189, S170-S171. doi:10.1016/j.toxlet.2009.06.698

DOI
10.1016/j.toxlet.2009.06.698
Journal article

Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1

Megherbi, R., Kiorpelidou, E., Foster, B., Rowe, C., Naisbitt, D. J., Goldring, C. E., & Park, B. K. (2009). Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1. Toxicology and Applied Pharmacology, 238(2), 120-132. doi:10.1016/j.taap.2009.05.001

DOI
10.1016/j.taap.2009.05.001
Journal article

Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1

Megherbi, R., Kiorpelidou, E., Foster, B., Rowe, C., Naisbitt, D. J., Goldring, C. E., & Park, B. K. (2009). Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1. TOXICOLOGY AND APPLIED PHARMACOLOGY, 238(2), 120-132. doi:10.1016/j.taap.2009.05.001

DOI
10.1016/j.taap.2009.05.001
Journal article

Involvement of drug-specific CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T-cells in trimethoprim-mediated hepatitis

El-Ghaiesh, S., Lavergne, S., Farell, J., Syn, W., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2009). Involvement of drug-specific CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T-cells in trimethoprim-mediated hepatitis. In TOXICOLOGY Vol. 262 (pp. 12). doi:10.1016/j.tox.2009.04.010

DOI
10.1016/j.tox.2009.04.010
Conference Paper

A Mechanistic Investigation into the Irreversible Protein Binding and Antigenicity of <i>p</i>-Phenylenediamine

Jenkinson, C., Jenkins, R. E., Maggs, J. L., Kitteringham, N. R., Aleksic, M., Park, B. K., & Naisbitt, D. J. (2009). A Mechanistic Investigation into the Irreversible Protein Binding and Antigenicity of <i>p</i>-Phenylenediamine. CHEMICAL RESEARCH IN TOXICOLOGY, 22(6), 1172-1180. doi:10.1021/tx900095r

DOI
10.1021/tx900095r
Journal article

Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation

Callan, H. E., Jenkins, R. E., Maggs, J. L., Lavergne, S. N., Clarke, S. E., Naisbitt, D. J., & Park, B. K. (2009). Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation. CHEMICAL RESEARCH IN TOXICOLOGY, 22(5), 937-948. doi:10.1021/tx900034r

DOI
10.1021/tx900034r
Journal article

Investigation of the immunogenicity of <i>p</i>-phenylenediamine and Bandrowski's base in the mouse

Farrell, J., Jenkinson, C., Lavergne, S. N., Maggs, J. L., Park, B. K., & Naisbitt, D. J. (2009). Investigation of the immunogenicity of <i>p</i>-phenylenediamine and Bandrowski's base in the mouse. TOXICOLOGY LETTERS, 185(3), 153-159. doi:10.1016/j.toxlet.2008.12.008

DOI
10.1016/j.toxlet.2008.12.008
Journal article

A pathological environment can modify sulfamethoxazole metabolism in human antigen presenting cells, including dendritic cells

Lavergne, S. N., Wang, H., Park, B. K., & Naisbitt, D. J. (2009). A pathological environment can modify sulfamethoxazole metabolism in human antigen presenting cells, including dendritic cells. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 293-294). Retrieved from https://www.webofscience.com/

Conference Paper

Characterisation of p-phenylenediamine and Bandrowski's base-specific T-cell responses in the mouse.

Farrell, J., Jenkinson, C., Lavergne, S. N., Maggs, J. L., Park, B. K., & Naisbitt, D. J. (2009). Characterisation of p-phenylenediamine and Bandrowski's base-specific T-cell responses in the mouse.. Toxicol Lett., 185(153-15).

Journal article

Characterization of SMX disposition in bone marrow-derived dendritic cells, as a part of a mouse model of SMX immunogenicity

Elsheikh, A., Lavergne, S. N., Sathish, J., Park, B. K., & Naisbitt, D. J. (2009). Characterization of SMX disposition in bone marrow-derived dendritic cells, as a part of a mouse model of SMX immunogenicity. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 287-288). Retrieved from https://www.webofscience.com/

Conference Paper

Human antigen presenting cells can metabolize sulfamethoxazole to a protein reactive intermediate, leading to the formation of intracellular drug adducts that can stimulate drug specific T-cells from allergic patients

Lavergne, S. N., Wang, H., Castrejon, J. L., Park, B. K., & Naisbitt, D. J. (2009). Human antigen presenting cells can metabolize sulfamethoxazole to a protein reactive intermediate, leading to the formation of intracellular drug adducts that can stimulate drug specific T-cells from allergic patients. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 279). Retrieved from https://www.webofscience.com/

Conference Paper

Measurement of lymphocyte proliferation and cytokine secretion from para-phenylenediamine allergic patients and tolerant individuals

Jenkinson, C., Aleksic, M., Lavergne, S. N., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2009). Measurement of lymphocyte proliferation and cytokine secretion from para-phenylenediamine allergic patients and tolerant individuals. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 280). Retrieved from https://www.webofscience.com/

Conference Paper

Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP1

Megherbi, R., Kiorpelidou, E., Foster, B., Farrell, J., Rowe, C., Naisbitt, D. J., . . . Park, B. K. (2009). Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP1. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 292-293). Retrieved from https://www.webofscience.com/

Conference Paper

Stimulation of antigen-specific T-cells from allergic patients with sulfonamides and sulfonamide metabolites

Casterjon, J. L., Jenkinson, C., Gerber, B. O., Pichler, W. J., Park, B. K., & Naisbitt, D. J. (2009). Stimulation of antigen-specific T-cells from allergic patients with sulfonamides and sulfonamide metabolites. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 289-290). Retrieved from https://www.webofscience.com/

Conference Paper

Sulfamethoxazole metabolism by mouse splenocytes creates T-cell stimulatory hapten-protein complexes

Elsheikh, A., Castrejon, J. L., Lavergne, S. N., Park, B. K., & Naisbitt, D. J. (2009). Sulfamethoxazole metabolism by mouse splenocytes creates T-cell stimulatory hapten-protein complexes. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 288). Retrieved from https://www.webofscience.com/

Conference Paper

The multiple adduction reactions of nitroso sulfamethoxazole with cysteinyl residues of peptides and proteins: Implications for hapten formation, structure and stability

Callan, H. E., Jenkins, R. E., Maggs, J. L., Lavergne, S. N., Naisbitt, D. J., & Park, B. K. (2009). The multiple adduction reactions of nitroso sulfamethoxazole with cysteinyl residues of peptides and proteins: Implications for hapten formation, structure and stability. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 288-289). Retrieved from https://www.webofscience.com/

Conference Paper

2008

Nonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes: Implications for Bioanalysis of Sulfamethoxazole Metabolites

Sanderson, J. P., Hollis, F. J., Maggs, J. L., Clarke, S. E., Naisbitt, D. J., & Park, B. K. (2008). Nonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes: Implications for Bioanalysis of Sulfamethoxazole Metabolites. DRUG METABOLISM AND DISPOSITION, 36(12), 2424-2428. doi:10.1124/dmd.108.021246

DOI
10.1124/dmd.108.021246
Journal article

The roles of drug metabolism in the pathogenesis of T-cell-mediated drug hypersensitivity

Lavergne, S. N., Park, B. K., & Naisbitt, D. J. (2008). The roles of drug metabolism in the pathogenesis of T-cell-mediated drug hypersensitivity. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 8(4), 299-307. doi:10.1097/ACI.0b013e3283079c64

DOI
10.1097/ACI.0b013e3283079c64
Journal article

Stimulation of nitroso sulfamethoxazole-specific T-cells with structurally-related hydroxylamine and nitroso metabolites

Castrejon, J. L., Farrell, J., O'neill, P. M., Park, B. K., & Naisbitt, D. J. (2008). Stimulation of nitroso sulfamethoxazole-specific T-cells with structurally-related hydroxylamine and nitroso metabolites. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 65(6), 997. Retrieved from https://www.webofscience.com/

Journal article

<i>p</i>-Phenylenediamine-bound irreversibly to cysteine residues on human serum albumin activates T-cells from patients allergic to hair dye

Jenkinson, C., Jenkins, R. E., Pease, C. K., Kitteringham, N. R., Aleksic, M., Pirmohamed, M., . . . Naisbitt, D. J. (2008). <i>p</i>-Phenylenediamine-bound irreversibly to cysteine residues on human serum albumin activates T-cells from patients allergic to hair dye. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 984). Retrieved from https://www.webofscience.com/

Conference Paper

A mechanistic investigation into the binding of PPD to a cysteine containing peptide and the model protein glutathione-<i>S</i>-transferase Pi

Jenkinson, C., Jenkins, R. E., Pease, C. K., Kitteringham, N. R., Aleksic, M., Naisbitt, D. J., & Park, B. K. (2008). A mechanistic investigation into the binding of PPD to a cysteine containing peptide and the model protein glutathione-<i>S</i>-transferase Pi. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 996-997). Retrieved from https://www.webofscience.com/

Conference Paper

Activation of T-Cells from allergic patients and volunteers by <i>p</i>-phenylenediamine and Bandrowski's base

Coulter, E. M., Jenkinson, C., Wu, Y., Farrell, J., Foster, B., Smith, A., . . . Naisbitt, D. J. (2008). Activation of T-Cells from allergic patients and volunteers by <i>p</i>-phenylenediamine and Bandrowski's base. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 128(4), 897-905. doi:10.1038/sj.jid.5701071

DOI
10.1038/sj.jid.5701071
Journal article

Comparison of the functional characteristics of allergic and tolerant patient lymphocytes stimulated with <i>p</i>-phenylenediamine and Bandrowski's base

Coulter, E. M., Pease, C. K., White, A., Lockley, D., Basketter, D., Williams, D. P., . . . Naisbitt, D. J. (2008). Comparison of the functional characteristics of allergic and tolerant patient lymphocytes stimulated with <i>p</i>-phenylenediamine and Bandrowski's base. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 982-984). Retrieved from https://www.webofscience.com/

Conference Paper

Enhancing CD8 T Cell immunity with Dendritic Cells Induced to Secrete Interleukin-2

Yeang, H. X. A., Naisbitt, D. J., Park, K., & Sathish, J. G. (2008). Enhancing CD8 T Cell immunity with Dendritic Cells Induced to Secrete Interleukin-2. In IMMUNOLOGY Vol. 125 (pp. 140-141). Retrieved from https://www.webofscience.com/

Conference Paper

Investigation of the immunogenicity of p-phenylenediamine and Bandrowski's base

Farrell, J., Jenkinson, C., Coulter, E., Park, B. K., & Naisbitt, D. J. (2008). Investigation of the immunogenicity of p-phenylenediamine and Bandrowski's base. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 1000-1001). Retrieved from https://www.webofscience.com/

Conference Paper

2007

Drugs as Haptens, Antigens, and Immunogens

Park, B. K., Sanderson, J. P., & Naisbitt, D. J. (2007). Drugs as Haptens, Antigens, and Immunogens. In Drug Hypersensitivity (pp. 55-65). KARGER. doi:10.1159/000104189

DOI
10.1159/000104189
Chapter

Drug hypersensitivity reactions in patients with HIV disease.

Pirmohamed, M., Drummond, N. S., Naisbitt, D. J., & Park, B. K. (2007). Drug hypersensitivity reactions in patients with HIV disease.. Expert review of clinical immunology, 3(3), 395-410. doi:10.1586/1744666x.3.3.395

DOI
10.1586/1744666x.3.3.395
Journal article

Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling

Sanderson, J. P., Naisbitt, D. J., Farrell, J., Ashby, C. A., Tucker, M. J., Rieder, M. J., . . . Park, B. K. (2007). Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. Journal of Immunology, 178(9), 5533-5542.

Journal article

Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling

Sanderson, J. P., Naisbitt, D. J., Farrell, J., Ashby, C. A., Tucker, M. J., Rieder, M. J., . . . Park, B. K. (2007). Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. JOURNAL OF IMMUNOLOGY, 178(9), 5533-5542. doi:10.4049/jimmunol.178.9.5533

DOI
10.4049/jimmunol.178.9.5533
Journal article

Generation and characterization of antigen-specific CD4<SUP>+</SUP>, CD8<SUP>+</SUP>, and CD4<SUP>+</SUP>CD8<SUP>+</SUP> T-cell clones from patients with carbamazopine hypersensitivity

Wu, Y., Farrell, J., Pirmohmed, M., Park, B. K., & Naisbitt, D. J. (2007). Generation and characterization of antigen-specific CD4<SUP>+</SUP>, CD8<SUP>+</SUP>, and CD4<SUP>+</SUP>CD8<SUP>+</SUP> T-cell clones from patients with carbamazopine hypersensitivity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 119(4), 973-981. doi:10.1016/j.jaci.2006.12.617

DOI
10.1016/j.jaci.2006.12.617
Journal article

Immunological principles of T-cell-mediated adverse drug reactions in skin

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2007). Immunological principles of T-cell-mediated adverse drug reactions in skin. EXPERT OPINION ON DRUG SAFETY, 6(2), 109-124. doi:10.1517/14740338.6.2.109

DOI
10.1517/14740338.6.2.109
Journal article

Immunological principles of T-cell-mediated adverse drug reactions in skin

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2007). Immunological principles of T-cell-mediated adverse drug reactions in skin. Expert Opinion on Drug Safety, 6(2), 109-124. doi:10.1517/14740338.6.2.109

DOI
10.1517/14740338.6.2.109
Journal article

Activation of human dendritic cells by <i>p</i>-phenylenediamine

Coulter, E. M., Farrell, J., Mathews, K. L., Maggs, J. L., Pease, C. K., Lockley, D. J., . . . Naisbitt, D. J. (2007). Activation of human dendritic cells by <i>p</i>-phenylenediamine. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 320(2), 885-892. doi:10.1124/jpet.106.113803

DOI
10.1124/jpet.106.113803
Journal article

Investigation of the immunogenicity of diclofenac and diclofenac metabolites

Naisbitt, D. J., Sanderson, L. S., Meng, X., Stachulski, A. V., Clarke, S. E., & Park, B. K. (2007). Investigation of the immunogenicity of diclofenac and diclofenac metabolites. TOXICOLOGY LETTERS, 168(1), 45-50. doi:10.1016/j.toxlet.2006.10.014

DOI
10.1016/j.toxlet.2006.10.014
Journal article

Activation of T-cells from allergic patients and volunteers with p-phenylenediamine and Bandrowski's base

Coulter, E. M., Jenkinson, C., Wu, Y., Pease, C. K., Basketter, D. A., Friedmann, P. S., . . . Naisbitt, D. J. (2007). Activation of T-cells from allergic patients and volunteers with p-phenylenediamine and Bandrowski's base. J Invest Dermatol.

Journal article

Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling

Sanderson, J. P., Naisbitt, D. J., Farrell, J., Ashby, C. A., Tucker, M. J., Rieder, M. J., . . . Park, B. K. (2007). Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. Journal of Immunology, 178(9), 5533-5542. Retrieved from http://www.jimmunol.org/cgi/reprint/178/9/5533

Journal article

2006

The 2nd International Drug Hypersensitivity Meeting

Alfirevic, A., & Naisbitt, D. J. (2006). The 2nd International Drug Hypersensitivity Meeting. Expert Opinion on Drug Safety, 5(5), 729-734. doi:10.1517/14740338.5.5.729

DOI
10.1517/14740338.5.5.729
Journal article

The 2nd International Drug Hypersensitivity Meeting 18 - 21 April 2006, The University of Liverpool, Liverpool, UK.

Alfirevic, A., & Naisbitt, D. J. (2006). The 2nd International Drug Hypersensitivity Meeting 18 - 21 April 2006, The University of Liverpool, Liverpool, UK.. Expert opinion on drug safety, 5(5), 729-734. doi:10.1517/14740338.5.5.729

DOI
10.1517/14740338.5.5.729
Journal article

Systemic illness with skin eruption, fever and positive lymphocyte transformation test in a patient on irbesartan

Constable, S., Farrell, J., Naisbitt, D., King, C., Leonard, N., & Pirmohamed, M. (2006). Systemic illness with skin eruption, fever and positive lymphocyte transformation test in a patient on irbesartan. BRITISH JOURNAL OF DERMATOLOGY, 155(2), 491-493. doi:10.1111/j.1365-2133.2006.07338.x

DOI
10.1111/j.1365-2133.2006.07338.x
Journal article

Activation of T cells by carbamazepine and carbamazepine metabolites

Wu, Y., Sanderson, J. P., Farrell, J., Drummond, N. S., Hanson, A., Bowkett, E., . . . Naisbitt, D. J. (2006). Activation of T cells by carbamazepine and carbamazepine metabolites. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 118(1), 233-241. doi:10.1016/j.jaci.2006.03.005

DOI
10.1016/j.jaci.2006.03.005
Journal article

Drug-specific T cells in an HIV-positive patient with nevirapine-induced hepatitis

Drummond, N. S., Vilar, F. J., Naisbitt, D. J., Hanson, A., Woods, A., Park, B. K., & Pirmohamed, M. (2006). Drug-specific T cells in an HIV-positive patient with nevirapine-induced hepatitis. ANTIVIRAL THERAPY, 11(3), 393-395. Retrieved from https://www.webofscience.com/

Journal article

Role of bioactivation in drug-induced hypersensitivity reactions

Sanderson, J. P., Naisbitt, D. J., & Park, B. K. (2006). Role of bioactivation in drug-induced hypersensitivity reactions. AAPS JOURNAL, 8(1), E55-E64. doi:10.1208/aapsj080107

DOI
10.1208/aapsj080107
Journal article

Characterization of cytotoxic CD8+T-cells from carbamazepine hypersensitive patients

Wu, Y., Farrell, J., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2006). Characterization of cytotoxic CD8+T-cells from carbamazepine hypersensitive patients. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 61 (pp. 632). Retrieved from https://www.webofscience.com/

Conference Paper

Chemical and molecular investigation of hazard associated with drug bioactivation

Drummond, N. S., Gardner, I., Jones, R., Wood, T., Naisbitt, D. J., Owen, A., . . . Park, B. K. (2006). Chemical and molecular investigation of hazard associated with drug bioactivation. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 180-181). Retrieved from https://www.webofscience.com/

Conference Paper

Dendritic cell metabolism of sulfamethoxazole leads to increased CD40 expression: a key determinant of immunogenicity

Sanderson, J. P., Naisbitt, D. J., Farrell, J., Drummond, N., Mathews, K. L., Pirmohamed, M., . . . Park, B. K. (2006). Dendritic cell metabolism of sulfamethoxazole leads to increased CD40 expression: a key determinant of immunogenicity. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 61 (pp. 645). Retrieved from https://www.webofscience.com/

Conference Paper

Differential activation of lymphocytes from p-phenylenediamine sensitized patients and healthy volunteers

Coulter, E. M., Wu, Y., Farrell, J., Pease, C. K., Lockley, D. J., Basketter, D. A., . . . Naisbitt, D. J. (2006). Differential activation of lymphocytes from p-phenylenediamine sensitized patients and healthy volunteers. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 61 (pp. 639). Retrieved from https://www.webofscience.com/

Conference Paper

Drug Hypersnesitivity Meeting, Liverpool, 2006

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2006). Drug Hypersnesitivity Meeting, Liverpool, 2006. In 2nd International Drug Hypersnesitivity Meeting Vol. 38 (pp. 59). University Press: University Press.

Conference Paper

Metabolism of sulphamethoxazole by dendritic cells: Implications for hypersensitivity

Sanderson, J. P., Naisbitt, D. J., Farrell, J., Drummond, N., Mathews, K. L., Pirmohamed, M., . . . Park, B. K. (2006). Metabolism of sulphamethoxazole by dendritic cells: Implications for hypersensitivity. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 182-183). Retrieved from https://www.webofscience.com/

Conference Paper

The role of covalent binding in drug hypersensitivity

Sanderson, J. P., Naisbitt, D. J., & Park, B. K. (2006). The role of covalent binding in drug hypersensitivity. In W. J. Pichler (Ed.), Drug Hypersensitivity (pp. 460). Basel: Karger.

Chapter

The second drug hypersensitivity meeting 18th - 21st April 2006, The University of Liverpool

Alfirevic, A., & Naisbitt, D. J. (2006). The second drug hypersensitivity meeting 18th - 21st April 2006, The University of Liverpool. Expert Opinion in Drug Safety, 5(5), 729-734.

Journal article

2005

Errata

Errata (n.d.). International Journal of Clinical Practice, 59(11), 1371. doi:10.1111/j.1368-5031.2005.00729a.x

DOI
10.1111/j.1368-5031.2005.00729a.x
Journal article

Investigation of toxic metabolites during drug development.

Park, K., Williams, D. P., Naisbitt, D. J., Kitteringham, N. R., & Pirmohamed, M. (2005). Investigation of toxic metabolites during drug development.. Toxicology and applied pharmacology, 207(2 Suppl), 425-434. doi:10.1016/j.taap.2005.02.029

DOI
10.1016/j.taap.2005.02.029
Journal article

Carbamazepine-induced acute liver failure as part of the DRESS syndrome

Syn, W. K., Naisbitt, D. J., Holt, A. P., Pirmohamed, M., & Mutimer, D. J. (2005). Carbamazepine-induced acute liver failure as part of the DRESS syndrome. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 59(8), 988-991. doi:10.1111/j.1368-5031.2005.00550.x

DOI
10.1111/j.1368-5031.2005.00550.x
Journal article

Characterization of the T-cell response in a patient with phenindione hypersensitivity

Naisbitt, D. J., Farrell, J., Chamberlain, P. J., Hopkins, J. E., Berry, N. G., Pirmohamed, M., & Park, B. K. (2005). Characterization of the T-cell response in a patient with phenindione hypersensitivity. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 313(3), 1058-1065. doi:10.1124/jpet.105.083758

DOI
10.1124/jpet.105.083758
Journal article

Selective haptenation of cellular or extracellular protein by chemical allergens: Association with cytokine polarization

Hopkins, J. E., Naisbitt, D. J., Kitteringham, N. R., Dearman, R. J., Kimber, I., & Park, B. K. (2005). Selective haptenation of cellular or extracellular protein by chemical allergens: Association with cytokine polarization. CHEMICAL RESEARCH IN TOXICOLOGY, 18(2), 375-381. doi:10.1021/tx049688+

DOI
10.1021/tx049688+
Journal article

Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4<SUP>+</SUP> T-cells

Hopkins, J. E., Naisbitt, D. J., Humphreys, N., Dearman, R. J., Kimber, I., & Park, B. K. (2005). Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4<SUP>+</SUP> T-cells. TOXICOLOGY, 206(2), 221-231. doi:10.1016/j.tox.2004.08.010

DOI
10.1016/j.tox.2004.08.010
Journal article

Carbamazepine-induced acute liver failure as part of the DRESS syndrome (vol 59, pg 988, 2005)

Sun, W. K., Naisbitt, D. J., Holt, A. P., Primohamed, M., & Mutimer, D. J. (2005). Carbamazepine-induced acute liver failure as part of the DRESS syndrome (vol 59, pg 988, 2005). INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 59(11), 1371. doi:10.1111/j.1368-5031.2005.00729.x

DOI
10.1111/j.1368-5031.2005.00729.x
Journal article

Development of in vitro haptenation assays for skin sensitization through chemical and metabolic understanding

Pease, C. K. S., Divkovic, M., Payne, O., Vassallo, J. D., Coulter, E., Naisbitt, D. J., . . . Basketter, D. A. (2005). Development of in vitro haptenation assays for skin sensitization through chemical and metabolic understanding. In TOXICOLOGY LETTERS Vol. 158 (pp. S222-S223). Retrieved from https://www.webofscience.com/

Conference Paper

Drug presentation to T cells

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2005). Drug presentation to T cells. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 115(4), 876-877. doi:10.1016/j.jaci.2005.01.011

DOI
10.1016/j.jaci.2005.01.011
Journal article

Drug-specific lymphocyte proliferation in an HIV-positive patient with nevirapine hepatitis

Drummond, N. S., Vilar, J., Naisbitt, D. J., Hanson, A., Park, B. K., & Pirmohamed, M. (2005). Drug-specific lymphocyte proliferation in an HIV-positive patient with nevirapine hepatitis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(5), 635-636. Retrieved from https://www.webofscience.com/

Journal article

G-protein β3-subunit gene polymorphism and lymphocyte proliferation in carbamazepine hypersensitivity

Alfirevic, A., Naisbitt, D. J., Wu, Y., Farrell, J., Park, B. K., & Pirmohamed, M. (2005). G-protein β3-subunit gene polymorphism and lymphocyte proliferation in carbamazepine hypersensitivity. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(5), 645. Retrieved from https://www.webofscience.com/

Journal article

2004

A chemically inert drug can stimulate T cells in vitro by their T cell receptor in non-sensitised individuals

Engler, O. B., Strasser, I., Naisbitt, D. J., Cerny, A., & Pichler, W. J. (2004). A chemically inert drug can stimulate T cells in vitro by their T cell receptor in non-sensitised individuals. TOXICOLOGY, 197(1), 47-56. doi:10.1016/j.tox.2003.12.008

DOI
10.1016/j.tox.2003.12.008
Journal article

Drug hypersensitivity reactions in skin: understanding mechanisms and the development of diagnostic and predictive tests

Naisbitt, D. J. (2004). Drug hypersensitivity reactions in skin: understanding mechanisms and the development of diagnostic and predictive tests. TOXICOLOGY, 194(3), 179-196. doi:10.1016/j.tox.2003.09.004

DOI
10.1016/j.tox.2003.09.004
Journal article

Characterization of T-cell responses in phenindione hypersensitivity

Naisbitt, D. J., Farrell, J., Chamberlain, P. J., Park, B. K., & Pirmohamed, M. (2004). Characterization of T-cell responses in phenindione hypersensitivity. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 57 (pp. 675). Retrieved from https://www.webofscience.com/

Conference Paper

Characterization of drug-specific CD4<SUP>+</SUP> T-cells expressing the skin homing receptor CCR10 in lamotrigine hypersensitivity

Farrell, J., Gibney, C. A., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2004). Characterization of drug-specific CD4<SUP>+</SUP> T-cells expressing the skin homing receptor CCR10 in lamotrigine hypersensitivity. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 57 (pp. 690). Retrieved from https://www.webofscience.com/

Conference Paper

Diagnosis of anticonvulsant hypersensitivity syndrome using an in vitro lymphocyte proliferation assay

Farrell, J., Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2004). Diagnosis of anticonvulsant hypersensitivity syndrome using an in vitro lymphocyte proliferation assay. In TOXICOLOGY Vol. 194 (pp. 255-256). Retrieved from https://www.webofscience.com/

Conference Paper

Drug hypersensitivity reactions in the skin: Understanding mechanisms and the development of diagnostic and predictive tests

Naisbitt, D. J. (2004). Drug hypersensitivity reactions in the skin: Understanding mechanisms and the development of diagnostic and predictive tests. In TOXICOLOGY Vol. 194 (pp. 211-212). Retrieved from https://www.webofscience.com/

Conference Paper

Drug-specific proliferation of lymphocytes from patients hypersensitive to carbamazepine and oxcarbazepine: cross-reactivity and possible clinical implications

Wu, Y., Farrell, J., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2004). Drug-specific proliferation of lymphocytes from patients hypersensitive to carbamazepine and oxcarbazepine: cross-reactivity and possible clinical implications. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 57 (pp. 683). Retrieved from https://www.webofscience.com/

Conference Paper

T-cell recognition of carbamazepine and carbamazepine metabolites

Naisbitt, D. J., Wu, Y., Farrell, J., O'Neill, P. M., Pirmohamed, M., & Park, B. K. (2004). T-cell recognition of carbamazepine and carbamazepine metabolites. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 57(5), 669. Retrieved from https://www.webofscience.com/

Journal article

2003

Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-Cell responses in animals and humans

Farrell, J., Naisbitt, D. J., Drummond, N. S., Depta, J. P. H., Vilar, F. J., Pirmohamed, M., & Park, B. K. (2003). Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-Cell responses in animals and humans. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 306(1), 229-237. doi:10.1124/jpet.103.050112

DOI
10.1124/jpet.103.050112
Journal article

Characterization of drug-specific T cells in lamotrigine hypersensitivity

Naisbitt, D. J., Farrell, J., Wong, G., Depta, J. P. H., Dodd, C. C., Hopkins, J. E., . . . Park, B. K. (2003). Characterization of drug-specific T cells in lamotrigine hypersensitivity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 111(6), 1393-1403. doi:10.1067/mai.2003.1507

DOI
10.1067/mai.2003.1507
Journal article

Hypersensitivity reactions to carbamazepine: Characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones

Naisbitt, D. J., Britschgi, M., Wong, G., Farrell, J., Depta, J. P. H., Chadwick, D. W., . . . Park, B. K. (2003). Hypersensitivity reactions to carbamazepine: Characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones. MOLECULAR PHARMACOLOGY, 63(3), 732-741. doi:10.1124/mol.63.3.732

DOI
10.1124/mol.63.3.732
Journal article

Abacavir hypersensitivity in human immunodeficiency virus-positive patients:: demonstration of the presence of drug-specific lymphocyte proliferation <i>in vitro</i>

Dodd, C. C., Naisbitt, D. J., Vilar, F. J., Gordon, S. F., Maggs, J. L., Park, B. K., & Pirmohamed, M. (2003). Abacavir hypersensitivity in human immunodeficiency virus-positive patients:: demonstration of the presence of drug-specific lymphocyte proliferation <i>in vitro</i>. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 55 (pp. 421). Retrieved from https://www.webofscience.com/

Conference Paper

Characterisation of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and man

Farrell, J., Naisbitt, D. J., Depta, J. P. H., Pichler, W. J., Pirmohamed, M., & Park, B. K. (2003). Characterisation of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and man. TOXICOLOGY, 192(1), 83-84. Retrieved from https://www.webofscience.com/

Journal article

Characterization of lamotrigine-specific T cells from hypersensitive patients.

Naisbitt, D. J., Farrell, J., Hopkins, J. E., Wong, G., Pichler, W. J., Pirmohamed, M., & Park, K. (2003). Characterization of lamotrigine-specific T cells from hypersensitive patients.. In TOXICOLOGICAL SCIENCES Vol. 72 (pp. 52). Retrieved from https://www.webofscience.com/

Conference Paper

Distribution of antigen formation: a determinant of the nature of a cellular immune response to simple chemicals

Hopkins, J. E., Naisbitt, D. J., Dearman, R. J., Kimber, I., & Park, B. K. (2003). Distribution of antigen formation: a determinant of the nature of a cellular immune response to simple chemicals. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 55 (pp. 444). Retrieved from https://www.webofscience.com/

Conference Paper

Hypersensitivity reactions to lamotrigine: Characterization of drug-specific T-cell clones

Naisbitt, D. J., Farrell, J., Wong, G., Dodd, C. C., Hopkins, J. E., Depta, J. P. H., . . . Park, B. K. (2003). Hypersensitivity reactions to lamotrigine: Characterization of drug-specific T-cell clones. In TOXICOLOGY Vol. 192 (pp. 82-83). Retrieved from https://www.webofscience.com/

Conference Paper

Immunopharmacology of hypersensitivity reactions to drugs

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2003). Immunopharmacology of hypersensitivity reactions to drugs. CURRENT ALLERGY AND ASTHMA REPORTS, 3(1), 22-29. doi:10.1007/s11882-003-0006-9

DOI
10.1007/s11882-003-0006-9
Journal article

Mechanisms of drug hypersensitivity in HIV-infected patients: the role of the immune system.

Vilar, F. J., Naisbitt, D. J., Park, B. K., & Pirmohamed, M. (2003). Mechanisms of drug hypersensitivity in HIV-infected patients: the role of the immune system.. Journal of HIV therapy, 8(2), 42-47.

Journal article

The immunogenicity of diclofenac and its acyl glucuronide metabolite in the mouse <i>in vivo</i>

Kenny, J. R., Naisbitt, D. J., Stachulski, A. W., Hopkins, J. E., Dearman, R. J., Kimber, I., . . . Park, B. K. (2003). The immunogenicity of diclofenac and its acyl glucuronide metabolite in the mouse <i>in vivo</i>. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 55 (pp. 435). Retrieved from https://www.webofscience.com/

Conference Paper

The relationship between cellular disposition and cytokine polarization for simple haptens.

Hopkins, J. E., Naisbitt, D. J., Dearman, R. J., Kimber, I., & Park, K. (2003). The relationship between cellular disposition and cytokine polarization for simple haptens.. In TOXICOLOGICAL SCIENCES Vol. 72 (pp. 54). Retrieved from https://www.webofscience.com/

Conference Paper

2002

The danger hypothesis - potential role in idiosyncratic drug reactions

Pirmohamed, M., Naisbitt, D. J., Gordon, F., & Park, B. K. (2002). The danger hypothesis - potential role in idiosyncratic drug reactions. TOXICOLOGY, 181, 55-63. doi:10.1016/S0300-483X(02)00255-X

DOI
10.1016/S0300-483X(02)00255-X
Journal article

Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation

Naisbitt, D. J., Farrell, J., Gordon, S. F., Maggs, J. L., Burkhart, C., Pichler, W. J., . . . Park, B. K. (2002). Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation. MOLECULAR PHARMACOLOGY, 62(3), 628-637. doi:10.1124/mol.62.3.628

DOI
10.1124/mol.62.3.628
Journal article

Are chemically reactive metabolites responsible for adverse reactions to drugs?

Williams, D. P., Kitteringham, N. R., Naisbitt, D. J., Pirmohamed, M., Smith, D. A., & Park, B. K. (2002). Are chemically reactive metabolites responsible for adverse reactions to drugs?. Current drug metabolism, 3(4), 351-366. doi:10.2174/1389200023337423

DOI
10.2174/1389200023337423
Journal article

Toxicophores: Groups and metabolic routes associated with increased safety risk

Williams, D. P., & Naisbitt, D. J. (2002). Toxicophores: Groups and metabolic routes associated with increased safety risk. CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 5(1), 104-115. Retrieved from https://www.webofscience.com/

Journal article

Anticonvulsant hypersensitivity syndrome: Methodology to investigate the role of metabolism and processing of carbamazepine to T-cells

Naisbitt, D. J., Depta, J., Wong, G., Farrell, J., Chadwick, D. W., Pichler, W. J., . . . Park, B. K. (2002). Anticonvulsant hypersensitivity syndrome: Methodology to investigate the role of metabolism and processing of carbamazepine to T-cells. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 53 (pp. 443P). Retrieved from https://www.webofscience.com/

Conference Paper

Anticonvulsant hypersensitivity syndrome: characterization of the phenotype and cytokine profile of carabamazepine-specific T-cell clones

Naisbitt, D. J., Britschgi, M., Wong, G., Farrell, J., Chadwick, D. W., Pichler, W. J., . . . Park, B. K. (2002). Anticonvulsant hypersensitivity syndrome: characterization of the phenotype and cytokine profile of carabamazepine-specific T-cell clones. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 53 (pp. 418P-419P). Retrieved from https://www.webofscience.com/

Conference Paper

Cellular and molecular pathophysiology of cutaneous drug reactions.

Pichler, W. J., Yawalkar, N., Britschgi, M., Depta, J., Strasser, I., Schmid, S., . . . Naisbitt, D. (2002). Cellular and molecular pathophysiology of cutaneous drug reactions.. American journal of clinical dermatology, 3(4), 229-238. doi:10.2165/00128071-200203040-00001

DOI
10.2165/00128071-200203040-00001
Journal article

Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and MHC-restricted antigen presentation

Naisbitt, D. J., Farrell, J., Gordon, S. F., Maggs, J. L., Burkhart, C., Pichler, W. J., . . . Park, B. K. (2002). Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and MHC-restricted antigen presentation. Mol. Pharmacol., 62(3), 628-637. Retrieved from http://molpharm.aspetjournals.org/cgi/reprint/62/3/628?ck=nck

Journal article

Exposure of mice to sulfamethoxazole metabolite stimulates interleukin 5 expression

Hopkins, J., Naisbitt, D. J., Humphreys, N., Dearman, R. J., Kimber, I., & Park, B. K. (2002). Exposure of mice to sulfamethoxazole metabolite stimulates interleukin 5 expression. In TOXICOLOGY Vol. 178 (pp. 41-42). Retrieved from https://www.webofscience.com/

Conference Paper

MHC-restricted and processing dependent presentation of drug metabolite-modified cellular proteins to T-cells in the rat

Farrell, J., Gordon, S. F., Naisbitt, D. J., Gallimore, A., Burkhart, C., Pichler, W. J., . . . Park, B. K. (2002). MHC-restricted and processing dependent presentation of drug metabolite-modified cellular proteins to T-cells in the rat. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 53 (pp. 442P). Retrieved from https://www.webofscience.com/

Conference Paper

2001

Metabolic activation in drug allergies

Park, B. K., Naisbitt, D. J., Gordon, S. F., Kitteringham, N. R., & Pirmohamed, M. (2001). Metabolic activation in drug allergies. TOXICOLOGY, 158(1-2), 11-23. doi:10.1016/S0300-483X(00)00397-8

DOI
10.1016/S0300-483X(00)00397-8
Journal article

Antigenicity and immunogenicity of sulphamethoxazole:: demonstration of metabolism-dependent haptenation and T-cell proliferation <i>in vivo</i>

Naisbitt, D. J., Gordon, S. F., Pirmohamed, M., Burkhart, C., Cribb, A. E., Pichler, W. J., & Park, B. K. (2001). Antigenicity and immunogenicity of sulphamethoxazole:: demonstration of metabolism-dependent haptenation and T-cell proliferation <i>in vivo</i>. BRITISH JOURNAL OF PHARMACOLOGY, 133(2), 295-305. doi:10.1038/sj.bjp.0704074

DOI
10.1038/sj.bjp.0704074
Journal article

Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+T-cells

Burkhart, C., Von Greyerz, S., Depta, J. P. H., Naisbitt, D. J., Britschgi, M., Park, K. B., & Pichler, W. J. (2001). Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+T-cells. BRITISH JOURNAL OF PHARMACOLOGY, 132(3), 623-630. doi:10.1038/sj.bjp.0703845

DOI
10.1038/sj.bjp.0703845
Journal article

Reactive metabolites and their role in drug reactions

Naisbitt, D. J., Williams, D. P., Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (2001). Reactive metabolites and their role in drug reactions. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 1(4), 317-325. Retrieved from https://www.webofscience.com/

Journal article

The danger hypothesis: inflammation and idiosyncratic toxicity

Pirmohamed, M., Naisbitt, D. J., & Park, B. K. (2001). The danger hypothesis: inflammation and idiosyncratic toxicity. In TOXICOLOGY Vol. 164 (pp. 5). Retrieved from https://www.webofscience.com/

Conference Paper

2000

Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection

Naisbitt, D. J., Vilar, F. J., Stalford, A. C., Wilkins, E. G. L., Pirmohamed, M., & Park, B. K. (2000). Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection. AIDS RESEARCH AND HUMAN RETROVIRUSES, 16(18), 1929-1938. doi:10.1089/088922200750054657

DOI
10.1089/088922200750054657
Journal article

Metabolism of lamotrigine to a reactive arene oxide intermediate

Maggs, J. L., Naisbitt, D. J., Tettey, J. N. A., Pirmohamed, M., & Park, B. K. (2000). Metabolism of lamotrigine to a reactive arene oxide intermediate. CHEMICAL RESEARCH IN TOXICOLOGY, 13(11), 1075-1081. doi:10.1021/tx0000825

DOI
10.1021/tx0000825
Journal article

Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine

Williams, D. P., Pirmohamed, M., Naisbitt, D. J., Uetrecht, J. P., & Park, B. K. (2000). Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine. MOLECULAR PHARMACOLOGY, 58(1), 207-216. doi:10.1124/mol.58.1.207

DOI
10.1124/mol.58.1.207
Journal article

Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4<SUP>+</SUP> T cells from allergic individuals

Schnyder, B., Burkhart, C., Schnyder-Frutig, K., von Greyerz, S., Naisbitt, D. J., Pirmohamed, M., . . . Pichler, W. J. (2000). Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4<SUP>+</SUP> T cells from allergic individuals. JOURNAL OF IMMUNOLOGY, 164(12), 6647-6654. doi:10.4049/jimmunol.164.12.6647

DOI
10.4049/jimmunol.164.12.6647
Journal article

Immunological principles of adverse drug reactions - The initiation and propagation of immune responses elicited by drug treatment

Naisbitt, D. J., Gordon, S. F., Pirmohamed, M., & Park, B. K. (2000). Immunological principles of adverse drug reactions - The initiation and propagation of immune responses elicited by drug treatment. DRUG SAFETY, 23(6), 483-507. doi:10.2165/00002018-200023060-00002

DOI
10.2165/00002018-200023060-00002
Journal article

Metabolism of lamotrigine to a reactive arene oxide intermediate

Maggs, J. L., Naisbitt, D. J., Tetty, J. N., Pirmohamed, M., & Park, B. K. (2000). Metabolism of lamotrigine to a reactive arene oxide intermediate. Chemical Research in Toxicology, 11(11), 1075-1081.

Journal article

Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection.

Naisbitt, D. J., Vilar, F. J., Stalford, A. C., Wilkins, E. G., Pirmohamed, M., & Park, B. K. (2000). Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection.. AIDS research and human retroviruses, 16(18), 1926-1938.

Journal article

1999

Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity

Naisbitt, D. J., Hough, S. J., Gill, H. J., Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (1999). Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity. BRITISH JOURNAL OF PHARMACOLOGY, 126(6), 1393-1407. doi:10.1038/sj.bjp.0702453

DOI
10.1038/sj.bjp.0702453
Journal article

1998

Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs

Naisbitt, D. J., Williams, D. P., O'Neill, P. M., Maggs, J. L., Willock, D. J., Pirmohamed, M., & Park, B. K. (1998). Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs. CHEMICAL RESEARCH IN TOXICOLOGY, 11(12), 1586-1595. doi:10.1021/tx980148k

DOI
10.1021/tx980148k
Journal article

1997

Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: Possible role in agranulocytosis

Williams, D. P., Pirmohamed, M., Naisbitt, D. J., Maggs, J. L., & Park, B. K. (1997). Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: Possible role in agranulocytosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 283(3), 1375-1382. Retrieved from https://www.webofscience.com/

Journal article

The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat

Gill, H. J., Hough, S. J., Naisbitt, D. J., Maggs, J. L., Kitteringham, N. R., Pirmohamed, M., & Park, B. K. (1997). The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 282(2), 795-801. Retrieved from https://www.webofscience.com/

Journal article

Disposition of amodiaquine and related antimalarial agents in human neutrophils: Implications for drug design

Naisbitt, D. J., Ruscoe, J. E., Williams, D., ONeill, P. M., Pirmohamed, M., & Park, B. K. (1997). Disposition of amodiaquine and related antimalarial agents in human neutrophils: Implications for drug design. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 280(2), 884-893. Retrieved from https://www.webofscience.com/

Journal article

1996

Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity.

Naisbitt, D. J., ONeill, P. M., Pirmohamed, M., & Park, B. K. (1996). Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 6(13), 1511-1516. doi:10.1016/S0960-894X(96)00260-0

DOI
10.1016/S0960-894X(96)00260-0
Journal article

Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component

Hawley, S. R., Bray, P. G., ONeill, P. M., Naisbitt, D. J., Park, B. K., & Ward, S. A. (1996). Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 40(10), 2345-2349. doi:10.1128/AAC.40.10.2345

DOI
10.1128/AAC.40.10.2345
Journal article