Publications
2024
Omeprazole-Associated Atypical Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in a Patient with Positive In Vitro Diagnostic Testing to Multiple Proton Pump Inhibitors.
Grice, S., Hammond, S., Hampson, L., Wagner, A., & Naisbitt, D. J. (2024). Omeprazole-Associated Atypical Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in a Patient with Positive In Vitro Diagnostic Testing to Multiple Proton Pump Inhibitors.. Chemical research in toxicology, 37(9), 1484-1487. doi:10.1021/acs.chemrestox.4c00225
Intratumoral antigen signaling traps CD8<sup>+</sup> T cells to confine exhaustion to the tumor site.
Takahashi, M., So, T. Y., Chamberlain-Evans, V., Hughes, R., Yam-Puc, J. C., Kania, K., . . . Thaventhiran, J. E. D. (2024). Intratumoral antigen signaling traps CD8<sup>+</sup> T cells to confine exhaustion to the tumor site.. Science immunology, 9(95), eade2094. doi:10.1126/sciimmunol.ade2094
Lymphocyte transformation tests predict delayed-type allergy to piperacillin/tazobactam in patients with cystic fibrosis.
Roehmel, J. F., Rohrbach, A., Staab, D., Mall, M. A., Ogese, M., Doerfler, F., & Naisbitt, D. (2024). Lymphocyte transformation tests predict delayed-type allergy to piperacillin/tazobactam in patients with cystic fibrosis.. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 23(3), 573-578. doi:10.1016/j.jcf.2023.12.003
Glycolysis: An early marker for vancomycin-specific T-cell activation.
Gardner, J., Hammond, S., Jensen, R., Gibson, A., Krantz, M. S., Ardern-Jones, M., . . . Naisbitt, D. J. (2024). Glycolysis: An early marker for vancomycin-specific T-cell activation.. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 54(1), 21-33. doi:10.1111/cea.14423
Patients with <scp>naproxen‐induced</scp> liver injury display T‐cell memory responses toward an oxidative (S)‐<scp>O‐Desmethyl</scp> Naproxen metabolite but not the acyl glucuronide
Thomson, P., Fragkas, N., Kafu, L. M., Aithal, G. P., Lucena, M. I., Terracciano, L., . . . Naisbitt, D. J. (n.d.). Patients with <scp>naproxen‐induced</scp> liver injury display T‐cell memory responses toward an oxidative (S)‐<scp>O‐Desmethyl</scp> Naproxen metabolite but not the acyl glucuronide. Allergy. doi:10.1111/all.15830
Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-Desmethyl Naproxen metabolite but not the acyl glucuronide
Thomson, P., Fragkas, N., Kafu, L. M., Aithal, G. P., Lucena, M. I., Terracciano, L., . . . Naisbitt, D. J. (2023). Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-Desmethyl Naproxen metabolite but not the acyl glucuronide. In ALLERGY. doi:10.1111/all.15830
2023
Investigating the Immune Basis of Green Tea Extract Induced Liver Injury in Healthy Donors Expressing HLA-B*35:01.
Line, J., Ali, S. -E., Grice, S., Rao, T., & Naisbitt, D. J. (2023). Investigating the Immune Basis of Green Tea Extract Induced Liver Injury in Healthy Donors Expressing HLA-B*35:01.. Chemical research in toxicology, 36(12), 1872-1875. doi:10.1021/acs.chemrestox.3c00253
HLA-C*15:02 and epidermal growth factor receptor inhibitor-induced erosive pustular dermatosis of the scalp
Zhang, Y., Grice, S., Wang, N., Liu, Y., Zhao, Q., Liu, T., . . . Zhang, F. (2023). HLA-C*15:02 and epidermal growth factor receptor inhibitor-induced erosive pustular dermatosis of the scalp. CLINICAL AND EXPERIMENTAL DERMATOLOGY. doi:10.1093/ced/llad282
A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment
Ogese, M. O., Lister, A., Farrell, L., Gardner, J., Kafu, L., Ali, S. -E., . . . Naisbitt, D. J. (2023). A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment. TOXICOLOGICAL SCIENCES. doi:10.1093/toxsci/kfad101
Why drug exposure is frequently associated with T-cell mediated cutaneous hypersensitivity reactions
Line, J., Saville, E., Meng, X., & Naisbitt, D. (2023). Why drug exposure is frequently associated with T-cell mediated cutaneous hypersensitivity reactions. FRONTIERS IN TOXICOLOGY, 5. doi:10.3389/ftox.2023.1268107
What’s been Hapten-ing over the last 88 years?
Thomson, P., Hammond, S., Meng, X., & Naisbitt, D. J. (n.d.). What’s been Hapten-ing over the last 88 years?. Medicinal Chemistry Research. doi:10.1007/s00044-023-03091-1
P1095: COVID-19 VACCINE RESPONSES IN FOLLICULAR LYMPHOMA: DETERMINANTS OF HUMORAL AND CELLULAR IMMUNITY IN THE PETREA TRIAL OF FRONTLINE CHEMOIMMUNOTHERAPY
Jer Lim, Y., Ward, V., Farrell, L., Naisbitt, D., Brown, A., Phillips, E., . . . Pettitt, A. (n.d.). P1095: COVID-19 VACCINE RESPONSES IN FOLLICULAR LYMPHOMA: DETERMINANTS OF HUMORAL AND CELLULAR IMMUNITY IN THE PETREA TRIAL OF FRONTLINE CHEMOIMMUNOTHERAPY. HemaSphere, 7(S3), e49729ac. doi:10.1097/01.hs9.0000971276.49729.ac
Dapsone hypersensitivity syndrome
Zhao, Q., Sun, L., Sun, Y., Naisbitt, D., Liu, H., & Zhang, F. (2023). Dapsone hypersensitivity syndrome. CHINESE MEDICAL JOURNAL, 136(13), 1560-1562. doi:10.1097/CM9.0000000000002492
Activation of Human CD8+ T Cells with Nitroso Dapsone-Modified HLA-B*13:01-Binding Peptides.
Almutairi, M., Lister, A., Zhao, Q., Line, J., Adair, K., Tailor, A., . . . Naisbitt, D. J. (2023). Activation of Human CD8+ T Cells with Nitroso Dapsone-Modified HLA-B*13:01-Binding Peptides.. Journal of immunology (Baltimore, Md. : 1950), 210(8), 1031-1042. doi:10.4049/jimmunol.2200531
Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System
Ali, S. -E., Meng, X., Kafu, L., Hammond, S., Zhao, Q., Ogese, M., . . . Naisbitt, D. J. (2023). Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System. CHEMICAL RESEARCH IN TOXICOLOGY, 36(3), 390-401. doi:10.1021/acs.chemrestox.2c00343
Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury
Ali, S. -E., Waddington, J. C., Lister, A., Sison-Young, R., Jones, R. P., Rehman, A. H., . . . Meng, X. (2023). Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury. TOXICOLOGICAL SCIENCES, 192(1), 106-116. doi:10.1093/toxsci/kfad015
Activation of tolvaptan-responsive T-cell clones with the structurally-related mozavaptan
Hammond, S., Meng, X., Mosedale, M., & Naisbitt, D. J. (2023). Activation of tolvaptan-responsive T-cell clones with the structurally-related mozavaptan. Toxicology Letters, 373, 148-151. doi:10.1016/j.toxlet.2022.11.017
Investigating T cell responses to a major catechin found in green tea (epigallocathechin-3-O-gallate-EGCG) in healthy donors expressing HLAB*35:01
Line, J., Ali, S. -E., Grice, S., & Naisbitt, D. (2023). Investigating T cell responses to a major catechin found in green tea (epigallocathechin-3-O-gallate-EGCG) in healthy donors expressing HLAB*35:01. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 180 (pp. 520-521). Retrieved from https://www.webofscience.com/
2022
Pathology of T-cell-mediated drug hypersensitivity reactions and impact of tolerance mechanisms on patient susceptibility
Line, J., Thomson, P., & Naisbitt, D. J. (2022). Pathology of T-cell-mediated drug hypersensitivity reactions and impact of tolerance mechanisms on patient susceptibility. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 22(4), 226-233. doi:10.1097/ACI.0000000000000834
T-cell-mediated hypersensitivity to lumacaftor and ivacaftor in cystic fibrosis
Semic-Jusufagic, A., Ogese, M. O., Edwards, C., Wilkinson, M., Nissenbaum, C., Lee, T., . . . Naisbitt, D. J. (2022). T-cell-mediated hypersensitivity to lumacaftor and ivacaftor in cystic fibrosis. PEDIATRIC ALLERGY AND IMMUNOLOGY, 33(6). doi:10.1111/pai.13815
Does immune checkpoint inhibitor therapy increase the frequency of adverse reactions to concomitant medications?
Hammond, S., Olsson-Brown, A., Grice, S., & Naisbitt, D. J. (2022). Does immune checkpoint inhibitor therapy increase the frequency of adverse reactions to concomitant medications?. CLINICAL AND EXPERIMENTAL ALLERGY, 52(5), 600-603. doi:10.1111/cea.14134
Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity
Hammond, S., Olsson-Brown, A., Grice, S., Gibson, A., Gardner, J., Castrejon-Flores, J. L., . . . Naisbitt, D. J. (2022). Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity. TOXICOLOGICAL SCIENCES, 186(1), 58-69. doi:10.1093/toxsci/kfab144
Characterization of Teicoplanin-Specific T-Cells from Drug Naïve Donors Expressing HLA-A*32:01.
Gardner, J., Ogese, M., Betts, C. J., Pirmohamed, M., & Naisbitt, D. J. (2022). Characterization of Teicoplanin-Specific T-Cells from Drug Naïve Donors Expressing HLA-A*32:01.. Chemical research in toxicology, 35(2), 199-202. doi:10.1021/acs.chemrestox.1c00425
2021
HLA Class-II. Restricted CD8<SUP>+</SUP> T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients
Zhao, Q., Almutairi, M., Tailor, A., Lister, A., Harper, N., Line, J., . . . Naisbitt, D. J. (2021). HLA Class-II. Restricted CD8<SUP>+</SUP> T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 141(10), 2412-+. doi:10.1016/j.jid.2021.03.014
HLA Allele-Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction.
Jaruthamsophon, K., Thomson, P. J., Sukasem, C., Naisbitt, D. J., & Pirmohamed, M. (2021). HLA Allele-Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction.. Annual review of pharmacology and toxicology, 62, 509-529. doi:10.1146/annurev-pharmtox-052120-014115
Drug hapten-specific T-cell activation: Current status and unanswered questions
Adair, K., Meng, X., & Naisbitt, D. J. (2021). Drug hapten-specific T-cell activation: Current status and unanswered questions. PROTEOMICS, 21(17-18). doi:10.1002/pmic.202000267
Deciphering Adverse Drug Reactions: <i>In Vitro</i> Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01
Ogese, M. O., Lister, A., Gardner, J., Meng, X., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2021). Deciphering Adverse Drug Reactions: <i>In Vitro</i> Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01. TOXICOLOGICAL SCIENCES, 183(1), 139-153. doi:10.1093/toxsci/kfab084
Extracellular Vesicles from Human Plasma Show a Distinctive Proteome and miRNome Profile in Patients with Severe Cutaneous Adverse Reactions
Salinas-Jaramillo, O., Monroy-Arreola, A., Herrera-Norena, S., Guzman-Ortiz, A. L., Hernandez-Hernandez, A., Mendez-Flores, S., . . . Castrejon-Flores, J. L. (2021). Extracellular Vesicles from Human Plasma Show a Distinctive Proteome and miRNome Profile in Patients with Severe Cutaneous Adverse Reactions. CHEMICAL RESEARCH IN TOXICOLOGY, 34(7), 1738-1748. doi:10.1021/acs.chemrestox.1c00047
Drug-specific T-cell responses in patients with liver injury following treatment with the BACE inhibitor atabecestat
Thomson, P. J., Kafu, L., Meng, X., Snoeys, J., De Bondt, A., De Maeyer, D., . . . Naisbitt, D. J. (2021). Drug-specific T-cell responses in patients with liver injury following treatment with the BACE inhibitor atabecestat. ALLERGY, 76(6), 1825-1835. doi:10.1111/all.14652
T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab
Hammond, S., Olsson-Brown, A., Gardner, J., Thomson, P., Ali, S. -E., Jolly, C., . . . Naisbitt, D. (2021). T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 9(5). doi:10.1136/jitc-2021-002521
<i>HLA-B*13:01</i> Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients
Satapornpong, P., Pratoomwun, J., Rerknimitr, P., Klaewsongkram, J., Nakkam, N., Rungrotmongkol, T., . . . Sukasem, C. (2021). <i>HLA-B*13:01</i> Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.661135
Characterization of T-Cell Responses to SMX and SMX-NO in Co-Trimoxazole Hypersensitivity Patients Expressing <i>HLA-B*13:01</i>
Pratoomwun, J., Thomson, P., Jaruthamsophon, K., Tiyasirichokchai, R., Jinda, P., Rerkpattanapipat, T., . . . Sukasem, C. (2021). Characterization of T-Cell Responses to SMX and SMX-NO in Co-Trimoxazole Hypersensitivity Patients Expressing <i>HLA-B*13:01</i>. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.658593
In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs
Naisbitt, D. (2021). In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs. Frontiers in Immunology. doi:10.3389/fimmu.2021.630530
T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses
Ogbe, A., Kronsteiner, B., Skelly, D. T., Pace, M., Brown, A., Adland, E., . . . Dunachie, S. (2021). T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-21856-3
Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol
Setiabudi, W., Hungerford, D., Subramaniam, K., Vaselli, N. M., Shaw, V. E., Wilton, M., . . . French, N. (2021). Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol. BMJ Open, 11(3), e048317. doi:10.1136/bmjopen-2020-048317
Drug allergy to CFTR modulator therapy associated with lumacaftor-specific CD4<SUP>+</SUP> T lymphocytes
Roehmel, J. F., Ogese, M. O., Rohrbach, A., Mall, M. A., & Naisbitt, D. J. (2021). Drug allergy to CFTR modulator therapy associated with lumacaftor-specific CD4<SUP>+</SUP> T lymphocytes. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147(2), 753-+. doi:10.1016/j.jaci.2020.05.041
Shedding Light on Drug-Induced Liver Injury: Activation of T Cells From Drug Naive Human Donors With Tolvaptan and a Hydroxybutyric Acid Metabolite
Hammond, S., Gibson, A., Jaruthamsophon, K., Roth, S., Mosedale, M., & Naisbitt, D. J. (2021). Shedding Light on Drug-Induced Liver Injury: Activation of T Cells From Drug Naive Human Donors With Tolvaptan and a Hydroxybutyric Acid Metabolite. TOXICOLOGICAL SCIENCES, 179(1), 95-107. doi:10.1093/toxsci/kfaa157
Biopsy Pathology and Immunohistochemistry of a Case of Immune-Mediated Drug-Induced Liver Injury With Atabecestat
De Jonghe, S., Weinstock, D., Aligo, J., Washington, K., & Naisbitt, D. (2021). Biopsy Pathology and Immunohistochemistry of a Case of Immune-Mediated Drug-Induced Liver Injury With Atabecestat. HEPATOLOGY, 73(1), 452-455. doi:10.1002/hep.31403
2020
Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury
Waddington, J. C., Ali, S. -E., Penman, S. L., Whitaker, P., Hamlett, J., Chadwick, A., . . . Meng, X. (2020). Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 33(12), 2939-2943. doi:10.1021/acs.chemrestox.0c00400
Tolvaptan- and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury
Gibson, A., Hammond, S., Jaruthamsophon, K., Roth, S., Mosedale, M., & Naisbitt, D. J. (2020). Tolvaptan- and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 33(11), 2745-2748. doi:10.1021/acs.chemrestox.0c00328
Characterization of Clozapine-Responsive Human T Cells
Ogese, M. O., Lister, A., Jenkins, R. E., Meng, X., Alfirevic, A., Douglas, L., . . . Naisbitt, D. J. (2020). Characterization of Clozapine-Responsive Human T Cells. JOURNAL OF IMMUNOLOGY, 205(9), 2375-+. doi:10.4049/jimmunol.2000646
HLA DaB1*15:01-DQB1*06:02-Restricted Human CD4+T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts
Tailor, A., Meng, X., Adair, K., Farrell, J., Waddington, J. C., Daly, A., . . . Naisbitt, D. J. (2020). HLA DaB1*15:01-DQB1*06:02-Restricted Human CD4+T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts. TOXICOLOGICAL SCIENCES, 178(1), 115-126. doi:10.1093/toxsci/kfaa128
Characterization of amoxicillin and clavulanic acid specific T-cell clones from patients with immediate drug hypersensitivity
Ariza, A., Fernandez-Santamaria, R., Meng, X., Salas, M., Ogese, M. O., Tailor, A., . . . Naisbitt, D. J. (2020). Characterization of amoxicillin and clavulanic acid specific T-cell clones from patients with immediate drug hypersensitivity. ALLERGY, 75(10), 2562-2573. doi:10.1111/all.14298
Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation
Waddington, J. C., Meng, X., Illing, P. T., Tailor, A., Adair, K., Whitaker, P., . . . Park, B. K. (2020). Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation. TOXICOLOGICAL SCIENCES, 177(2), 454-465. doi:10.1093/toxsci/kfaa124
Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds.
Ogese, M. O., Watkinson, J., Lister, A., Faulkner, L., Gibson, A., Hillegas, A., . . . Naisbitt, D. J. (2020). Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds.. Toxicological sciences : an official journal of the Society of Toxicology, 175(2), 266-278. doi:10.1093/toxsci/kfaa034
Current perspective of the etiopathogenesis of delayed-type, and T-cell-mediated drug-related skin diseases
Vocanson, M., Naisbitt, D. J., & Nicolas, J. -F. (2020). Current perspective of the etiopathogenesis of delayed-type, and T-cell-mediated drug-related skin diseases. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(4), 1142-1144. doi:10.1016/j.jaci.2020.01.030
Immune dysregulation increases the incidence of delayed-type drug hypersensitivity reactions
Naisbitt, D. J., Olsson-Brown, A., Gibson, A., Meng, X., Ogese, M. O., Tailor, A., & Thomson, P. (2020). Immune dysregulation increases the incidence of delayed-type drug hypersensitivity reactions. ALLERGY, 75(4), 781-797. doi:10.1111/all.14127
Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA‐B*57:01 binding and T‐cell activation
Thomson, P. J., Illing, P. T., Farrell, J., Alhaidari, M., Bell, C. C., Berry, N., . . . Naisbitt, D. J. (2020). Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA‐B*57:01 binding and T‐cell activation. ALLERGY, 75(3), 636-647. doi:10.1111/all.14057
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
Weaver, R. J., Blomme, E. A., Chadwick, A. E., Copple, I. M., Gerets, H. H. J., Goldring, C. E., . . . Park, B. K. (2020). Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models. NATURE REVIEWS DRUG DISCOVERY, 19(2), 131-148. doi:10.1038/s41573-019-0048-x
T-Cell Activation by Low Molecular Weight Drugs and Factors That Influence Susceptibility to Drug Hypersensitivity
Hammond, S., Thomson, P. J., Ogese, M. O., & Naisbitt, D. J. (2020). T-Cell Activation by Low Molecular Weight Drugs and Factors That Influence Susceptibility to Drug Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 33(1), 77-94. doi:10.1021/acs.chemrestox.9b00327
2019
Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system.
Ogese, M. O., Jenkins, R. E., Adair, K., Tailor, A., Meng, X., Faulkner, L. L., . . . Betts, C. (2019). Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system.. Hepatology, 70(5), 1732-1749. doi:10.1002/hep.30701
Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo
Tailor, A., Waddington, J. C., Hamlett, J., Maggs, J., Kafu, L., Farrell, J., . . . Meng, X. (2019). Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo. CHEMICAL RESEARCH IN TOXICOLOGY, 32(10), 2095-2106. doi:10.1021/acs.chemrestox.9b00282
Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01
Zhao, Q., Alhilali, K., Alzahrani, A., Almutairi, M., Amjad, J., Liu, H., . . . Naisbitt, D. J. (2019). Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01. Allergy, 74(8), 1533-1548. doi:10.1111/all.13769
Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers
Alhilali, K. A., Al-Attar, Z., Gibson, A., Tailor, A., Meng, X., Monshouwer, M., . . . Naisbitt, D. J. (2019). Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers. TOXICOLOGICAL SCIENCES, 168(2), 597-609. doi:10.1093/toxsci/kfz007
Characterization Of Amoxicillin- And Clavulanic Acid-Specific T-Cells In Patients With Amoxicillin-Clavulanic Acid Hypersensitivity Reactions
Ariza, A., Isabel Montanez, M., Ogese, M. O., Tailor, A., Fernandez, T. D., Torres, M. J., & Naisbitt, D. J. (2019). Characterization Of Amoxicillin- And Clavulanic Acid-Specific T-Cells In Patients With Amoxicillin-Clavulanic Acid Hypersensitivity Reactions. In JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Vol. 143 (pp. AB184). doi:10.1016/j.jaci.2018.12.563
A child with a SCAR. A laboratory confirmed case of DRESS syndrome to piperacillin
Diacono, D., Mwenechanya, J., Mayell, S. J., & Naisbitt, D. J. (2019). A child with a SCAR. A laboratory confirmed case of DRESS syndrome to piperacillin. In CLINICAL AND EXPERIMENTAL ALLERGY Vol. 49 (pp. 1674-1675). Retrieved from https://www.webofscience.com/
Beta-lactam protein binding leads to the presentation of novel MHC peptides, generating a potential immunogen for drug-hypersensitive reactions
Waddington, J., Meng, X., Illing, P., Tailor, A., Jenkins, R., Purcell, A., . . . Park, B. (2019). Beta-lactam protein binding leads to the presentation of novel MHC peptides, generating a potential immunogen for drug-hypersensitive reactions. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 176 (pp. 3004-3005). Retrieved from https://www.webofscience.com/
Characterization of amoxicillin- and clavulanic acid-specific T-cells in patients with amoxicillin-clavulanic acid hypersensitivity reactions
Ariza Veguillas, A., Salas, M., Ogese, M. O., Montanez, M. I., Fernandez, T., Mayorga, C., . . . Naisbitt, D. J. (2019). Characterization of amoxicillin- and clavulanic acid-specific T-cells in patients with amoxicillin-clavulanic acid hypersensitivity reactions. In ALLERGY Vol. 74 (pp. 84-85). Retrieved from https://www.webofscience.com/
2018
HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors
Usui, T., Tailor, A., Faulkner, L., Meng, X., Farrell, J., Daly, A. K., . . . Naisbitt, D. J. (2018). HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 31(10), 1022-1024. doi:10.1021/acs.chemrestox.8b00163
The skin as a metabolic and immune-competent organ: implications fordrug-induced skin rash.
Sharma, A., Saito, Y., Hung, S. -I., Naisbitt, D., Uetrecht, J., & Bussiere, J. (2018). The skin as a metabolic and immune-competent organ: implications fordrug-induced skin rash.. Journal of immunotoxicology, 1-12. doi:10.1080/1547691x.2018.1514444
Immune drug-induced liver disease and drugs
Waddington, J. C., Meng, X., Naisbitt, D. J., & Park, B. K. (2018). Immune drug-induced liver disease and drugs. Current Opinion in Toxicology, 10, 46-53. doi:10.1016/j.cotox.2017.12.006
Mechanisms leading to T-cell activation in drug hypersensitivity
Meng, X., Yerly, D., & Naisbitt, D. J. (2018). Mechanisms leading to T-cell activation in drug hypersensitivity. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 18(4), 317-324. doi:10.1097/ACI.0000000000000458
Up-Regulation of T-Cell Activation MicroRNAs in Drug-Specific CD4(+) T-Cells from Hypersensitive Patients
Monroy-Arreola, A., Duran-Figueroa, N. V., Mendez-Flores, S., Dominguez-Cherit, J., Watkinson, J., Badillo-Corona, J. A., . . . Castrejon-Flores, J. L. (2018). Up-Regulation of T-Cell Activation MicroRNAs in Drug-Specific CD4<SUP>+</SUP> T-Cells from Hypersensitive Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 31(6), 454-461. doi:10.1021/acs.chemrestox.7b00330
Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity
Usui, T., Faulkner, L., Farrell, J., French, N. S., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2018). Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity. CHEMICAL RESEARCH IN TOXICOLOGY, 31(3), 165-167. doi:10.1021/acs.chemrestox.8b00030
Implications of HLA-allele associations for the study of type IV drug hypersensitivity reactions
Sullivan, A., Watkinson, J., Waddington, J., Park, B. K., & Naisbitt, D. J. (2018). Implications of HLA-allele associations for the study of type IV drug hypersensitivity reactions. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 14(3), 261-274. doi:10.1080/17425255.2018.1441285
Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017)
Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2018). Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1952. doi:10.4049/jimmunol.1800020
The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017)
Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2018). The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1951. doi:10.4049/jimmunol.1800019
Immune Mechanisms in Drug-Induced Liver Injury
Jaeschke, H., & Naisbitt, D. J. (2018). Immune Mechanisms in Drug-Induced Liver Injury. In DRUG-INDUCED LIVER TOXICITY (pp. 511-531). doi:10.1007/978-1-4939-7677-5_25
State-of-the-Art and New Options to Assess T Cell Activation by Skin Sensitizers: Cosmetics Europe Workshop
van Vliet, E., Kuehnl, J., Goebel, C., Martinozzi-Teissier, S., Alepee, N., Ashikaga, T., . . . Petersohn, D. (n.d.). State-of-the-Art and New Options to Assess T Cell Activation by Skin Sensitizers: Cosmetics Europe Workshop. ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 35(2), 179-192. doi:10.14573/altex.1709011
β-lactam hypersensitivity involves expansion of circulating and skin-resident Th22 cells
sullivan, A., Wang, E., Farrell, J., Whitaker, P., Faulkner, L., Peckham, D., . . . Naisbitt, D. (2018). β-lactam hypersensitivity involves expansion of circulating and skin-resident Th22 cells. Journal of Allergy and Clinical Immunology, 141(01), 235-249.E8. doi:10.1016/j.jaci.2017.01.020
2017
Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts
Amali, M. O., Jenkins, R. E., Meng, X., Faulkner, L., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2017). Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2097-2099. doi:10.1021/acs.chemrestox.7b00291
Dapsone and Nitroso Dapsone Activation of Naive T-Cells from Healthy Donors
Alzahrani, A., Ogese, M., Meng, X., Waddington, J. C., Tailor, A., Farrell, J., . . . Naisbitt, D. (2017). Dapsone and Nitroso Dapsone Activation of Naive T-Cells from Healthy Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2174-2186. doi:10.1021/acs.chemrestox.7b00263
Assessment of anti-piperacillin IgG binding to structurally-related drug protein adducts
Park, B. K., & Naisbitt, D. (n.d.). Assessment of anti-piperacillin IgG binding to structurally-related drug protein adducts. Chemical Research in Toxicology.
The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors
Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2017). The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors. JOURNAL OF IMMUNOLOGY, 199(4), 1223-1237. doi:10.4049/jimmunol.1602029
Identification of drug- and drug-metabolite immune responses originating from both naïve and memory T-cells.
Gibson, A., Faulkner, L., Wood, S., Park, B. K., & Naisbitt, D. J. (2017). Identification of drug-and drug-metabolite immune responses originating from both naive and memory T cells. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 140(2), 578-+. doi:10.1016/j.jaci.2016.11.032
Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells
Ogese, M. O., Faulkner, L., Jenkins, R. E., French, N. S., Copple, I. M., Antoine, D. J., . . . Naisbitt, D. J. (2017). Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells. TOXICOLOGICAL SCIENCES, 158(1), 76-89. doi:10.1093/toxsci/kfx069
Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development
Goldring, C., Weaver, R., Kramer, B., Klingmueller, U., Oppelt, A., Van der Water, B., . . . Park, B. K. (2017). Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development. In COMPREHENSIVE MEDICINAL CHEMISTRY III, VOL 4: EXPERIMENTAL ADME AND TOXICOLOGY (pp. 217-238). doi:10.1016/B978-0-12-409547-2.12384-4
Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients.
Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2017). Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients.. Journal of Immunology, 198(11), 4217-4227. doi:10.4049/jimmunol.1700209
Detection of drug-responsive B lymphocytes and antidrug IgG in patients with β-lactam hypersensitivity
Amali, M. O., Sullivan, A., Jenkins, R. E., Farrell, J., Meng, X., Faulkner, L., . . . Naisbitt, D. J. (2017). Detection of drug-responsive B lymphocytes and antidrug IgG in patients with β-lactam hypersensitivity. ALLERGY, 72(6), 896-907. doi:10.1111/all.13087
Assessment of gene expression profiles of peripheral blood mononuclear cells from patients with a history of carbamazepine hypersensitivity
Yip, V., Zhang, E., Clarke, K., Francis, B., Rainbow, L., Falciani, F., . . . Pirmohamed, M. (2017). Assessment of gene expression profiles of peripheral blood mononuclear cells from patients with a history of carbamazepine hypersensitivity. In LANCET Vol. 389 (pp. 104). Retrieved from https://www.webofscience.com/
Trimethoprim-induced aseptic meningism
Lochlainn, M. N., Gooi, H. C., Ogese, M. O., Naisbitt, D. J., & Jafar-Mohammadi, B. (2017). Trimethoprim-induced aseptic meningism. BRITISH JOURNAL OF HOSPITAL MEDICINE, 78(2), 108-109. doi:10.12968/hmed.2017.78.2.108
Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury
Usui, T., Meng, X., Saide, K., Farrell, J., Thomson, P., Whitaker, P., . . . Naisbitt, D. J. (2017). Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury. TOXICOLOGICAL SCIENCES, 155(2), 420-431. doi:10.1093/toxsci/kfw218
Drug-specific CD4<SUP>+</SUP> T-cell immune responses are responsible for antituberculosis drug-induced maculopapular exanthema and drug reaction with eosinophilia and systemic symptoms syndrome
Ye, Y. -M., Hur, G. -Y., Kim, S. -H., Ban, G. -Y., Jee, Y. -K., Naisbitt, D. J., . . . Kim, S. -H. (2017). Drug-specific CD4<SUP>+</SUP> T-cell immune responses are responsible for antituberculosis drug-induced maculopapular exanthema and drug reaction with eosinophilia and systemic symptoms syndrome. BRITISH JOURNAL OF DERMATOLOGY, 176(2), 378-386. doi:10.1111/bjd.14839
Human leukocyte antigen and idiosyncratic adverse drug reactions
Usui, T., & Naisbitt, D. J. (2017). Human leukocyte antigen and idiosyncratic adverse drug reactions. DRUG METABOLISM AND PHARMACOKINETICS, 32(1), 21-30. doi:10.1016/j.dmpk.2016.11.003
Immunological Mechanisms of Drug Hypersensitivity
Meng, X., Ariza, A., Waddington, J., Park, K., & Naisbitt, D. (2016). Immunological Mechanisms of Drug Hypersensitivity. CURRENT PHARMACEUTICAL DESIGN, 22(45), 6734-6747. doi:10.2174/1381612822666161003115103
New Approaches to Investigate Drug-Induced Hypersensitivity
Ogese, M. O., Ahmed, S., Alferivic, A., Betts, C. J., Dickinson, A., Faulkner, L., . . . Naisbitt, D. J. (2017). New Approaches to Investigate Drug-Induced Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 30(1), 239-259. doi:10.1021/acs.chemrestox.6b00333
Temozolomide-induced drug rash with eosinophilia and systemic symptoms with positive lymphocyte transformation test
Poyner, E., Naisbitt, D. J., Farrell, J., Nagarajan, S., Ellis, R., & Fatah, S. (2017). Temozolomide-induced drug rash with eosinophilia and systemic symptoms with positive lymphocyte transformation test. In BRITISH JOURNAL OF DERMATOLOGY Vol. 177 (pp. 27). Retrieved from https://www.webofscience.com/
2016
No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with <i>HLA</i>-<i>DRB1</i>*07:01-Restricted Lapatinib-Induced Liver Injury
Faulkner, L., Meng, X., Naisbitt, D. J., Spraggs, C. F., & Park, B. K. (2016). No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with <i>HLA</i>-<i>DRB1</i>*07:01-Restricted Lapatinib-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 29(12), 2111-2113. doi:10.1021/acs.chemrestox.6b00400
Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity.
Faulkner, L., Gibson, A., Sullivan, A., Tailor, A., Usui, T., Alfirevic, A., . . . Park, B. K. (2016). Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity. TOXICOLOGICAL SCIENCES, 154(2), 416-429. doi:10.1093/toxsci/kfw177
Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury
Usui, T., Whitaker, P., Meng, X., Watson, J., Antoine, D. J., French, N. S., . . . Naisbitt, D. J. (2016). Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 29(11), 1793-1795. doi:10.1021/acs.chemrestox.6b00393
Effect of Repeated Daily Dosing with 2,4-Dinitrochlorobenzene on Glutathione Biosynthesis and Nrf2 Activation in Reconstructed Human Epidermis
Spriggs, S., Sheffield, D., Olayanju, A., Kitteringham, N. R., Naisbitt, D. J., & Aleksic, M. (2016). Effect of Repeated Daily Dosing with 2,4-Dinitrochlorobenzene on Glutathione Biosynthesis and Nrf2 Activation in Reconstructed Human Epidermis. TOXICOLOGICAL SCIENCES, 154(1), 5-15. doi:10.1093/toxsci/kfw140
Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients
Meng, X., Earnshaw, C. J., Tailor, A., Jenkins, R. E., Waddington, J. C., Whitaker, P., . . . Park, B. K. (2016). Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 29(10), 1762-1772. doi:10.1021/acs.chemrestox.6b00253
Update on Advances in Research on Idiosyncratic Drug-Induced Liver Injury
Kim, S. -H., & Naisbitt, D. J. (2016). Update on Advances in Research on Idiosyncratic Drug-Induced Liver Injury. ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 8(1), 3-11. doi:10.4168/aair.2016.8.1.3
2015
The chemical, genetic and immunological basis of idiosyncratic drug-induced liver injury
Tailor, A., Faulkner, L., Naisbitt, D. J., & Park, B. K. (2015). The chemical, genetic and immunological basis of idiosyncratic drug-induced liver injury. HUMAN & EXPERIMENTAL TOXICOLOGY, 34(12), 1310-1317. doi:10.1177/0960327115606529
Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation
Naisbitt, D., Yang, E. L., Alhaidari, M., Berry, N., Lawrenson, A. S., Farrell, J., . . . Park, B. (2015). Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation. AIDS, 29(18), 2385-2395. doi:10.1097/QAD.0000000000000867
Cutaneous immunopathology of long-standing complex regional pain syndrome
Osborne, S., Farrell, J., Dearman, R. J., MacIver, K., Naisbitt, D., Moots, R., . . . Goebel, A. (2015). Cutaneous immunopathology of long-standing complex regional pain syndrome. European Journal of Pain, 19(10), 1516-1526. doi:10.1002/ejp.685
<i>In Vitro</i> Priming of Naive T-cells with <i>p</i>-Phenylenediamine and Bandrowski's Base
Gibson, A., Kim, S. -H., Faulkner, L., Evely, J., Pirmohamed, M., Park, K. B., & Naisbitt, D. J. (2015). <i>In Vitro</i> Priming of Naive T-cells with <i>p</i>-Phenylenediamine and Bandrowski's Base. CHEMICAL RESEARCH IN TOXICOLOGY, 28(10), 2069-2077. doi:10.1021/acs.chemrestox.5b00294
Characterization of amoxicillin‐ and clavulanic acid‐specific T cells in patients with amoxicillin‐clavulanate–induced liver injury
Kim, S. -H., Saide, K., Farrell, J., Faulkner, L., Tailor, A., Ogese, M., . . . Naisbitt, D. J. (2015). Characterization of amoxicillin‐ and clavulanic acid‐specific T cells in patients with amoxicillin‐clavulanate–induced liver injury. Hepatology, 62(3), 887-899. doi:10.1002/hep.27912
Glutathione metabolism in the HaCaT cell line as a model for the detoxification of the model sensitisers 2,4-dinitrohalobenzenes in human skin
Jacquoilleot, S., Sheffield, D., Olayanju, A., Sison-Young, R., Kitteringham, N. R., Naisbitt, D. J., & Aleksic, M. (2015). Glutathione metabolism in the HaCaT cell line as a model for the detoxification of the model sensitisers 2,4-dinitrohalobenzenes in human skin. TOXICOLOGY LETTERS, 237(1), 11-20. doi:10.1016/j.toxlet.2015.05.016
HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis
Ogese, M. O., Saide, K., Faulkner, L., Whitaker, P., Peckham, D., Alfirevic, A., . . . Naisbitt, D. J. (2015). HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis. CLINICAL AND EXPERIMENTAL ALLERGY, 45(8), 1305-1316. doi:10.1111/cea.12546
Promiscuous T-cell responses to drugs and drug-haptens
Yaseen, F. S., Saide, K., Kim, S. -H., Monshi, M., Tailor, A., Wood, S., . . . Naisbitt, D. J. (2015). Promiscuous T-cell responses to drugs and drug-haptens. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136(2), 474-+. doi:10.1016/j.jaci.2015.02.036
Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy
Wheatley, L. M., Plaut, M., Schwaninger, J. M., Banerji, A., Castells, M., Finkelman, F. D., . . . Trepanier, L. A. (2015). Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy. In JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Vol. 136 (pp. 262-+). doi:10.1016/j.jaci.2015.05.027
Activation of flucloxacillin-specific CD8+ T-cells with the potential to promote hepatocyte cytotoxicity in a mouse model
Nattrass, R., Faulkner, L., Vocanson, M., Antoine, D., Kipar, A., Kenna, G., . . . Naisbitt, D. (2015). Activation of flucloxacillin-specific CD8+ T-cells with the potential to promote hepatocyte cytotoxicity in a mouse model. Toxicological Sciences, 146(1), 146-156. doi:10.1093/toxsci/kfv077
Towards the development of mechanism-based biomarkers to diagnose drug hypersensitivity
Duran-Figueroa, N., Badillo-Corona, J. A., Naisbitt, D. J., & Castrejon-Flores, J. L. (2015). Towards the development of mechanism-based biomarkers to diagnose drug hypersensitivity. TOXICOLOGY RESEARCH, 4(4), 777-795. doi:10.1039/c4tx00238e
Negative regulation by PD-L1 during drug-specific priming of IL-22-secreting T cells and the influence of PD-1 on effector T cell function
Gibson, A., Ogese, M., Sullivan, A., Wang, E., Saide, K., Whitaker, P., . . . Naisbitt, D. J. (2015). Negative regulation by PD-L1 during drug-specific priming of IL-22-secreting T cells and the influence of PD-1 on effector T cell function. Journal of Immunology, 192(06), 2611-2621. doi:10.4049/jimmunol.1302720
Are drug metabolites able to cause T-cell-mediated hypersensitivity reactions?
Sullivan, A., Gibson, A., Park, B. K., & Naisbitt, D. J. (2015). Are drug metabolites able to cause T-cell-mediated hypersensitivity reactions?. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 11(3), 357-368. doi:10.1517/17425255.2015.992780
Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin
Meng, X., Maggs, J. L., Usui, T., Whitaker, P., French, N. S., Naisbitt, D. J., & Park, B. K. (2015). Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin. Chemical Research in Toxicology, 28(1), 51-58. doi:10.1021/tx500285k
Characterization of Peroxidases Expressed in Human AntigenPresenting Cells and Analysis of the Covalent Binding of NitrosoSulfamethoxazole to Myeloperoxidase
Ogese, M. O., Jenkins,, R. E., Maggs, J. L., Meng, X., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2015). Characterization of Peroxidases Expressed in Human AntigenPresenting Cells and Analysis of the Covalent Binding of NitrosoSulfamethoxazole to Myeloperoxidase. Chemical Research in Toxicology, 28(1), 144-154. doi:10.1021/tx500458k
CD4+and CD8+T-cells isolated from blood and skin of patients with β-lactam hypersensitivity secrete Interleukin-22, but not Interleukin-17
Sullivan, A., Faulkner, L., Farrell, J., Whitaker, P., Peckham, D., Park, B. K., & Naisbitt, D. (2015). CD4+and CD8+T-cells isolated from blood and skin of patients with β-lactam hypersensitivity secrete Interleukin-22, but not Interleukin-17. In ALLERGY Vol. 70 (pp. 25-26). Retrieved from https://www.webofscience.com/
Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses
Gibson, A., Faulkner, L., Ogese, M., Lichtenfels, M., Esser, P., Martin, S., . . . Naisbitt, D. (2015). Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses. In ALLERGY Vol. 70 (pp. 26). Retrieved from https://www.webofscience.com/
2014
Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial
Middleton, G., Silcocks, P., Cox, T. F., Valle, J., Wadsley, J., Propper, D., . . . Neoptolemos, J. P. (2014). Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial. The Lancet Oncology, 15(8), 829-840. doi:10.1016/S1470-2045(14)70236-0
Abacavir forms novel cross-linking abacavir protein adducts in patients
Meng, X., Lawrenson, A. S., Berry, N. G., Maggs, J. L., French, N. S., Back, D. J., . . . Park, B. K. (2014). Abacavir forms novel cross-linking abacavir protein adducts in patients. Chemical Research in Toxicology, 27(04), 524-535. doi:10.1021/tx400406p
HLA restriction of carbamazepine-specific T-cell clones from an HLA-A*31:01-positive hypersensitive patient
Lichtenfels, M., Farrell, J., Ogese, M. O., Bell, C. C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). HLA restriction of carbamazepine-specific T-cell clones from an HLA-A*31:01-positive hypersensitive patient. Chemical Research in Toxicology, 27(02), 175-177. doi:10.1021/tx400460w
In Vitro Diagnosis of Delayed-type Drug Hypersensitivity Mechanistic Aspects and Unmet Needs
Naisbitt, D. J., Nattrass, R. G., & Ogese, M. O. (2014). In Vitro Diagnosis of Delayed-type Drug Hypersensitivity Mechanistic Aspects and Unmet Needs. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 34(3), 691-+. doi:10.1016/j.iac.2014.04.009
T cell responses to drugs and drug metabolites.
Earnshaw, C. J., Pecaric-Petkovic, T., Park, B. K., & Naisbitt, D. J. (2014). T cell responses to drugs and drug metabolites.. Experientia supplementum (2012), 104, 137-163. doi:10.1007/978-3-0348-0726-5_10
The importance of hapten - protein complex formation in the development of drug allergy
Faulkner, L., Meng, X., Park, B. K., & Naisbitt, D. J. (2014). The importance of hapten - protein complex formation in the development of drug allergy. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 14(4), 293-300. doi:10.1097/ACI.0000000000000078
2013
The Generation, Detection, and Effects of Reactive Drug Metabolites
Stachulski, A. V., Baillie, T. A., Park, B. K., Obach, R. S., Dalvie, D. K., Williams, D. P., . . . Lennard, M. S. (2013). The Generation, Detection, and Effects of Reactive Drug Metabolites. MEDICINAL RESEARCH REVIEWS, 33(5), 985-1080. doi:10.1002/med.21273
Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFNβ interact with the endogenous cytokine and activate complement
Sethu, S., Govindappa, K., Quinn, P., Wadhwa, M., Stebbings, R., Boggild, M., . . . Sathish, J. (2013). Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFNβ interact with the endogenous cytokine and activate complement. CLINICAL IMMUNOLOGY, 148(2), 177-185. doi:10.1016/j.clim.2013.05.008
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., . . . Hengstler, J. G. (2013). Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. ARCHIVES OF TOXICOLOGY, 87(8), 1315-1530. doi:10.1007/s00204-013-1078-5
Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells
Bell, C. C., Castelazo, A. S., Yang, E. L., Maggs, J. L., Jeankins, R. E., Tugwood, J., . . . Park, B. K. (2013). Oxidative Bioactivation of Abacavir in Subcellular Fractions of Human Antigen Presenting Cells. CHEMICAL RESEARCH IN TOXICOLOGY, 26(7), 1064-1072. doi:10.1021/tx400041v
β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis
Jenkins, R. E., Yaseen, F. S., Monshi, M. M., Whitaker, P., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2013). β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis. CHEMICAL RESEARCH IN TOXICOLOGY, 26(6), 963-975. doi:10.1021/tx400124m
T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms
Bell, C. C., Faulkner, L., Martinsson, K., Farrell, J., Alfirevic, A., Tugwood, J., . . . Park, B. K. (2013). T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms. CHEMICAL RESEARCH IN TOXICOLOGY, 26(5), 759-766. doi:10.1021/tx400060p
Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients
Meng, X., Howarth, A., Earnshaw, C. J., Jenkins, R. E., French, N. S., Back, D. J., . . . Park, B. K. (2013). Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 26(4), 575-583. doi:10.1021/tx4000107
Challenges and approaches for the development of safer immunomodulatory biologics
Sathish, J. G., Sethu, S., Bielsky, M. -C., de Haan, L., French, N. S., Govindappa, K., . . . Park, B. K. (2013). Challenges and approaches for the development of safer immunomodulatory biologics. NATURE REVIEWS DRUG DISCOVERY, 12(4), 306-324. doi:10.1038/nrd3974
Human Leukocyte Antigen (HLA)-B<SUP>☆</SUP>57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury
Monshi, M. M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2013). Human Leukocyte Antigen (HLA)-B<SUP>☆</SUP>57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury. HEPATOLOGY, 57(2), 727-739. doi:10.1002/hep.26077
Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives
Farrell, J., Lichtenfels, M., Sullivan, A., Elliott, E. C., Alfirevic, A., Stachulski, A. V., . . . Park, B. K. (2013). Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132(2), 493-495. doi:10.1016/j.jaci.2013.02.045
Characterization of the B cell response in piperacillin hypersensitive patients with cystic fibrosis
Amali, M., Sullivan, A., Yaseen, F. S., Farrell, J., Faulkner, L., Whitaker, P., . . . Naisbitt, D. J. (2013). Characterization of the B cell response in piperacillin hypersensitive patients with cystic fibrosis. In IMMUNOLOGY Vol. 140 (pp. 192). Retrieved from https://www.webofscience.com/
Definition of the mechanistic basis immunological drug reactions using human cells
Naisbitt, D. J. (2013). Definition of the mechanistic basis immunological drug reactions using human cells. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 246. Retrieved from https://www.webofscience.com/
Idiosyncratic Adverse Drug Reactions: Current Concepts
Uetrecht, J., & Naisbitt, D. J. (2013). Idiosyncratic Adverse Drug Reactions: Current Concepts. PHARMACOLOGICAL REVIEWS, 65(2), 779-808. doi:10.1124/pr.113.007450
Negative regulation by PD-L1 during drug-specific priming of IL-22 secreting T-cells and the influence of PD-1 on effector T-cell function
Ogese, M. O., Gibson, A., Sullivan, A., Wang, E., Saide, K., Whitaker, P., . . . Naisbitt, D. (2013). Negative regulation by PD-L1 during drug-specific priming of IL-22 secreting T-cells and the influence of PD-1 on effector T-cell function. In IMMUNOLOGY Vol. 140 (pp. 206). Retrieved from https://www.webofscience.com/
2012
Explanation for <i>HLA</i>-<i>B</i>*<i>57</i>:<i>01</i>-linked immune-mediated abacavir-induced hypersensitivity
Alfirevic, A., Park, B. K., Pirmohamed, M., & Naisbitt, D. J. (2012). Explanation for <i>HLA</i>-<i>B</i>*<i>57</i>:<i>01</i>-linked immune-mediated abacavir-induced hypersensitivity. PHARMACOGENOMICS, 13(14), 1567-1569. doi:10.2217/PGS.12.146
IL-8 Release from Human Neutrophils Cultured with Pro-Haptenic Chemical Sensitizers
Kiorpelidou, E., Foster, B., Farrell, J., Ogese, M. O., Faulkner, L., Goldring, C. E., . . . Naisbitt, D. J. (2012). IL-8 Release from Human Neutrophils Cultured with Pro-Haptenic Chemical Sensitizers. CHEMICAL RESEARCH IN TOXICOLOGY, 25(10), 2054-2056. doi:10.1021/tx300350s
Nonimmediate β-lactam reactions in patients with cystic fibrosis
Whitaker, P., Naisbitt, D., & Peckham, D. (2012). Nonimmediate β-lactam reactions in patients with cystic fibrosis. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 12(4), 369-375. doi:10.1097/ACI.0b013e328355b849
<i>In silico</i> analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers
Alfirevic, A., Gonzalez-Galarza, F., Bell, C., Martinsson, K., Platt, V., Bretland, G., . . . Pirmohamed, M. (2012). <i>In silico</i> analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers. GENOME MEDICINE, 4. doi:10.1186/gm350
Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis
El-Ghaiesh, S., Monshi, M. M., Whitaker, P., Jenkins, R., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 341(3), 597-610. doi:10.1124/jpet.111.190900
The Development of <i>In Vitro</i> Culture Methods to Characterize Primary T-Cell Responses to Drugs
Faulkner, L., Martinsson, K., Santoyo-Castelazo, A., Cederbrant, K., Schuppe-Koistinen, I., Powell, H., . . . Park, B. K. (2012). The Development of <i>In Vitro</i> Culture Methods to Characterize Primary T-Cell Responses to Drugs. TOXICOLOGICAL SCIENCES, 127(1), 150-158. doi:10.1093/toxsci/kfs080
Characterisation of antidrug antibodies (ADA) against therapeutic interferon beta
Govindappa, K., Sethu, S., Wadwa, M., Stebbings, R., Kimber, I., Naisbitt, D. J., . . . Sathish, J. G. (2012). Characterisation of antidrug antibodies (ADA) against therapeutic interferon beta. In IMMUNOLOGY Vol. 137 (pp. 655-656). Retrieved from https://www.webofscience.com/
Characterisation of durg antigen-specific T-cell responses in multi-allergic patients with cystic fibrosis
Yaseen, F., Monshi, M., Farrell, J., Whitaker, P., Peckham, D., Pirmohamed, M., . . . Naisbitt, D. J. (2012). Characterisation of durg antigen-specific T-cell responses in multi-allergic patients with cystic fibrosis. J Allergy Clin Immunol.
Characterization of B-cell resposnes in piperacillin allergic and tolerant patients
Sullivan, A., Amali, M., Faulkner, L., Whitaker, P., Peckham, D., Pirmohamed, M., . . . Naisbitt, D. J. (2012). Characterization of B-cell resposnes in piperacillin allergic and tolerant patients. Allergy.
Characterization of drug presentation to T-lymphocytes using clones isolated from piperacillin hypersensitive human patients.
El-Ghaiesh, S., Monshi, M., Whitaker, P., Meng, X., Jenkins, R., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of drug presentation to T-lymphocytes using clones isolated from piperacillin hypersensitive human patients.. J Pharmacol Exp Ther, 341, 597-610.
Clinical picture of drug hypersensitivity reactions
Bell, C., Naisbitt, D. J., & Park, B. K. (2012). Clinical picture of drug hypersensitivity reactions. ALTA.
Development of in vitro assays to characterize primary T cell responses to drugs
Faulkner, J., Martinsson, K., Castelazo, A. S., Cederbrant, K., Schuppe-Koistinen, I., Powell, H., . . . Park, B. K. (2012). Development of in vitro assays to characterize primary T cell responses to drugs. Toxicological Sciences, 127, 150-158.
HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury
Monshi, M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2012). HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury. Hepatology.
IL-8 secretion from primary neutrophils cultured with haptenic and pro-haptenic chemical sensitizers
Kiorpelidou, E., Foster, B., Naisbitt, D. J., & Park, B. K. (2012). IL-8 secretion from primary neutrophils cultured with haptenic and pro-haptenic chemical sensitizers. Che Res Toxicol.
Multiple Drug Hypersensitivity (MDH): normal Treg cell function but enhanced in vivo activation of drug-specific T cells.
Daubner, B., Groux-Keller, M., Hausmann, O., Kawabata, T., Naisbitt, D. J., Park, B. K., . . . Pichler, W. J. (2012). Multiple Drug Hypersensitivity (MDH): normal Treg cell function but enhanced in vivo activation of drug-specific T cells.. Allergy, 187, 1398-1405.
Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells
Daubner, B., Groux-Keller, M., Hausmann, O. V., Kawabata, T., Naisbitt, D. J., Park, B. K., . . . Pichler, W. J. (2012). Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells. ALLERGY, 67(1), 58-66. doi:10.1111/j.1398-9995.2011.02720.x
Perspectives to predict idiosyncratic drug-induced liver injury in vitro.
Gibson, A., Eakins, R., Goldring, C. E. P., Naisbitt, D. J., Rowe, C., & Park, B. K. (2012). Perspectives to predict idiosyncratic drug-induced liver injury in vitro.. Drug Metabolism Reviews.
T-cell responses to drugs and drug metabolites
Earnshaw, C., Park, B. K., & Naisbitt, D. J. (2012). T-cell responses to drugs and drug metabolites. In S. F. Martin (Ed.), T Lymphocytes as Tools in Chemical and Drug Allergy (pp. 180-193). San Fransisco: Springer.
T-cell responses to flucloxacillin protein adducts in a mouse model of immunogenicity
Nattrass, R., Jenkins, R., Faulkner, L., Yaseen, F., Park, B. K., & Naisbitt, D. J. (2012). T-cell responses to flucloxacillin protein adducts in a mouse model of immunogenicity. Tox Sci.
T-cell responses to halogenated carbamazepine
Farrell, J., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2012). T-cell responses to halogenated carbamazepine. Chem Res Toxicol.
The generation, detection and effects of reactive drug metabolites. Med Res Reviews.
Baillie, T. A., Park, B. K., Obach, R. S., Dalvie, D. K., Williams, D. P., Srivastava, A., . . . Stachulski, A. V. (2012). The generation, detection and effects of reactive drug metabolites. Med Res Reviews.. Med Res Reviews.
The use of anti-programmed death ligand antibodies to enhance in vitro antigen-specific T-cell priming
Gibson, A., Faulkner, L., Park, B. K., & Naisbitt, D. J. (2012). The use of anti-programmed death ligand antibodies to enhance in vitro antigen-specific T-cell priming. Tox Sci.
2011
Establishment of an HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions
Bell, C., Martinsson, K., Faulkner, L., Alfirevic, A., French, N., Tugwood, J., . . . Park, B. K. (2011). Establishment of an HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions. TOXICOLOGY, 290(2-3), 132-133. doi:10.1016/j.tox.2011.09.057
Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients
Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 338(3), 841-849. doi:10.1124/jpet.111.183871
Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients
Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. Journal of Pharmacology and Experimental Therapeutics, 338(3), 841-849. doi:10.1124/jpet.111.183871
Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis
Whitaker, P., Meng, X., Lavergne, S. N., El-Ghaiesh, S., Monshi, M., Earnshaw, C., . . . Park, B. K. (2011). Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis. JOURNAL OF IMMUNOLOGY, 187(1), 200-211. doi:10.4049/jimmunol.1100647
Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity
Park, B. K., Laverty, H., Srivastava, A., Antoine, D. J., Naisbitt, D., & Williams, D. P. (2011). Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity. CHEMICO-BIOLOGICAL INTERACTIONS, 192(1-2), 30-36. doi:10.1016/j.cbi.2010.09.011
Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways
El-Ghaiesh, S., Sanderson, J. P., Farrell, J., Lavergne, S. N., Syn, W. -K., Pirmohamed, M., . . . Naisbitt, D. J. (2011). Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways. CHEMICAL RESEARCH IN TOXICOLOGY, 24(6), 791-793. doi:10.1021/tx2001256
Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis
Elsheikh, A., Castrejon, L., Lavergne, S. N., Whitaker, P., Monshi, M., Callan, H., . . . Naisbitt, D. J. (2011). Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis. Journal of Allergy and Clinical Immunology, 127(6), 1543-1551.e3. doi:10.1016/j.jaci.2010.12.1119
Managing the challenge of chemically reactive metabolites in drug development
Park, B. K., Boobis, A., Clarke, S., Goldring, C. E. P., Jones, D., Kenna, J. G., . . . Baillie, T. A. (2011). Managing the challenge of chemically reactive metabolites in drug development. NATURE REVIEWS DRUG DISCOVERY, 10(4), 292-306. doi:10.1038/nrd3408
Multiple drug hypersensitivity: role of T regulatory cells
Daubner, B., Groux-Keller, M., Kawabata, T., Naisbitt, D. J., Park, K. B., Thomas, W., . . . Pichler, W. J. (2011). Multiple drug hypersensitivity: role of T regulatory cells. In JOURNAL OF IMMUNOLOGY Vol. 186. Retrieved from https://www.webofscience.com/
Immune pathomechanism of drug hypersensitivity reactions
Pichler, W. J., Naisbitt, D. J., & Park, B. K. (2011). Immune pathomechanism of drug hypersensitivity reactions. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(3), S74-S81. doi:10.1016/j.jaci.2010.11.048
Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury
El-Ghaiesh, S., Sanderson, J. P., Farrell, J., Lavergne, S. N., Syn, W. -K., Pirmohamed, M., . . . Naisbitt, D. J. (2011). Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 128(3), 680-U368. doi:10.1016/j.jaci.2011.04.031
Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury.
El-Ghaiesh, S., Sanderson, J. P., Farrell, J., Lavergne, S. N., Syn, W. K., Pirmohamed, M., . . . Naisbitt, D. J. (2011). Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury.. J Allergy Clin Immunol., 128, 680-683.
Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity.
Park, B. K., Laverty, H., Srivastava, A., Antoine, D. J., Naisbitt, D., & Williams, D. P. (2011). Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity.. Chem Biol Interact., 192, 30-36.
Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis
Elsheikh, A., Castrejon, L., Lavergne, S. N., Whitaker, P., Monshi, M., Callan, H., . . . Naisbitt, D. J. (2011). Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127(6), 1543-U348. doi:10.1016/j.jaci.2010.12.1119
Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis.
Elsheikh, A., Castrejon, L., Lavergne, S. N., Whitaker, P., Monshi, M., Callan, H., . . . Naisbitt, D. J. (2011). Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis.. The Journal of allergy and clinical immunology, 127(6), 1543-51.e3. doi:10.1016/j.jaci.2010.12.1119
Immune pathomechanism of drug hypersensitivity reactions
Pichler, W. J., Naisbitt, D. J., & Park, B. K. (2011). Immune pathomechanism of drug hypersensitivity reactions. Journal of Allergy and Clinical Immunology, 127(S3), S74-S81.
Managing the challenge of chemically reactive metabolites in drug development.
Park, B. K., Boobis, A., Clarke, S., Goldring, C. E., Jones, D., Kenna, J. G., . . . Baillie, T. A. (2011). Managing the challenge of chemically reactive metabolites in drug development.. Nat Rev Drug Discov., 10, 292-306.
Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis.
Whitaker, P., Meng, X., Lavergne, S. N., El-Ghaiesh, S., Monshi, M., Earnshaw, C., . . . Park, B. K. (2011). Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis.. J Immunol., 187, 200-211.
rimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways.
El-Ghaiesh, S., Sanderson, J. P., Farrell, J., Lavergne, S. N., Syn, W. K., Pirmohamed, M., . . . Naisbitt, D. J. (2011). rimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways.. Chem Res Toxicol., 24, 791-793.
2010
Drug Antigenicity, Immunogenicity, and Costimulatory Signaling: Evidence for Formation of a Functional Antigen through Immune Cell Metabolism
Elsheikh, A., Lavergne, S. N., Castrejon, J. L., Farrell, J., Wang, H., Sathish, J., . . . Naisbitt, D. J. (2010). Drug Antigenicity, Immunogenicity, and Costimulatory Signaling: Evidence for Formation of a Functional Antigen through Immune Cell Metabolism. JOURNAL OF IMMUNOLOGY, 185(11), 6448-6460. doi:10.4049/jimmunol.1000889
Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer
Shaw, V. E., Naisbitt, D. J., Costello, E., Greenhalf, W., Park, B. K., Neoptolemos, J. P., & Middleton, G. W. (2010). Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer. EXPERT REVIEW OF VACCINES, 9(9), 1007-1016. doi:10.1586/ERV.10.92
Drug Metabolite-Specific Lymphocyte Responses in Sulfamethoxazole Allergic Patients with Cystic Fibrosis
Lavergne, S. N., Whitaker, P., Peckham, D., Conway, S., Park, B. K., & Naisbitt, D. J. (2010). Drug Metabolite-Specific Lymphocyte Responses in Sulfamethoxazole Allergic Patients with Cystic Fibrosis. CHEMICAL RESEARCH IN TOXICOLOGY, 23(6), 1009-1011. doi:10.1021/tx100151v
Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives
Castrejon, J. L., Lavergne, S. N., El-Sheikh, A., Farrell, J., Maggs, J. L., Sabbani, S., . . . Naisbitt, D. J. (2010). Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso Derivatives. CHEMICAL RESEARCH IN TOXICOLOGY, 23(1), 184-192. doi:10.1021/tx900329b
ADVERSE REACTIONS TO COLISTIN IN CYSTIC FIBROSIS: DOSE-DEPENDENT TOXICITY OR IMMUNE-MEDIATED REACTIONS?
Lavergne, S. N., Whitaker, P., Peckham, D., Conway, S., Gooi, J., Park, B. K., & Naisbitt, D. J. (2010). ADVERSE REACTIONS TO COLISTIN IN CYSTIC FIBROSIS: DOSE-DEPENDENT TOXICITY OR IMMUNE-MEDIATED REACTIONS?. In PEDIATRIC PULMONOLOGY (pp. 377). Retrieved from https://www.webofscience.com/
AN INSIGHT INTO CIRCULATING DRUG-SPECIFIC LYMPHOCYTES FROM CYSTIC FIBROSIS PATIENTS WITH A HISTORY OF DELAYED ALLERGIC REACTION TO ANTIBACTERIALS
Lavergne, S. N., Whitaker, P., Peckham, D., Conway, S., Gooi, J., Peckham, B. K., & Naisbitt, D. J. (2010). AN INSIGHT INTO CIRCULATING DRUG-SPECIFIC LYMPHOCYTES FROM CYSTIC FIBROSIS PATIENTS WITH A HISTORY OF DELAYED ALLERGIC REACTION TO ANTIBACTERIALS. In PEDIATRIC PULMONOLOGY (pp. 377). Retrieved from https://www.webofscience.com/
Characterization of <i>p</i>-Phenylenediamine-Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein
Jenkinson, C., Jenkins, R. E., Aleksic, M., Pirmohamed, M., Naisbitt, D. J., & Park, B. K. (2010). Characterization of <i>p</i>-Phenylenediamine-Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130(3), 732-742. doi:10.1038/jid.2009.271
Characterization of piperacillin-specific T-cell clones from hypersensitive patients with cystic fibrosis
El-Ghaiesh, S., Monshi, M., Jenkins, R., Meng, X., French, N., Whitaker, P., . . . Naisbitt, D. (2010). Characterization of piperacillin-specific T-cell clones from hypersensitive patients with cystic fibrosis. In IMMUNOLOGY Vol. 131 (pp. 117). Retrieved from https://www.webofscience.com/
Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer.
Shaw, V., Naisbitt, D. J., Costello, E., Greenhalf, W., Park, B. K., Neoptolemos, J. P., & Middleton, G. W. (2010). Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer.. Expert Reviews in Vaccines, 9, 1007-1016.
DRUG HYPERSENSITIVITY
Naisbitt, D. J., Park, B. K., & Demoly, P. (2010). DRUG HYPERSENSITIVITY. In S. Holgate (Ed.), Allergy (pp. 200). London: Elsveier.
Development of a neutrophil cell culture system to define the sensitizing potential of chemical allergens that acquire protein reactivity through metabolism
Kiorpelidou, E., Foster, B. J., Goldring, C., Naisbitt, D. J., & Park, K. (2010). Development of a neutrophil cell culture system to define the sensitizing potential of chemical allergens that acquire protein reactivity through metabolism. In IMMUNOLOGY Vol. 131 (pp. 171-172). Retrieved from https://www.webofscience.com/
Drug antigenicity, immunogencitiy, and co-stimulatory signalling: evidence for formation of a functional antigen through immune cell metabolism
Elsheikh, A., Lavergne, S. N., Castrejon, J. L., Farrell, J., Wang, H., Sathish, J., . . . Naisbitt, D. J. (2010). Drug antigenicity, immunogencitiy, and co-stimulatory signalling: evidence for formation of a functional antigen through immune cell metabolism. Journal of Immunology, 185, 6448-6460. doi:10.4049/jimmunol.1000889
Drug immunogenicity and co-stimulatory signalling: evidence for formation of a functional antigen through immune cell metabolism
Elsheikh, A., Lavergne, S., Castrejon, J., Sathish, J., Pichler, W. J., Park, B. K., & Naisbitt, D. J. (2010). Drug immunogenicity and co-stimulatory signalling: evidence for formation of a functional antigen through immune cell metabolism. In IMMUNOLOGY Vol. 131 (pp. 145). Retrieved from https://www.webofscience.com/
Drug-metabolite specific lymphocyte responses in sulfamethoxazole allergic patients with cystic fibrosis
Lavergne, S. N., Whitaker, P., Peckham, D., Conway, S., Park, B. K., & Naisbitt, D. J. (2010). Drug-metabolite specific lymphocyte responses in sulfamethoxazole allergic patients with cystic fibrosis. Chemical Research in Toxicology, 23, 1009-1011.
Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole hypersensitive patients with cystic fibrosis
Elsheikh, A., Monshi, M., Castrejon, J., Lavergne, S., Whitaker, P., Pichler, W. J., . . . Naisbitt, D. J. (2010). Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole hypersensitive patients with cystic fibrosis. IMMUNOLOGY, 131, 145-146. Retrieved from https://www.webofscience.com/
Establishment of a HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions
Bell, C., Martinsson, K., Faulkner, L., Alfirevic, A., French, N., Tugwood, J., . . . Park, B. K. (2010). Establishment of a HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions. In IMMUNOLOGY Vol. 131 (pp. 125). Retrieved from https://www.webofscience.com/
Involvement of drug-specific CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T-cells in trimethoprim-mediated hepatitis
El-Ghaiesh, S., Lavergne, S., Farrell, J., Syn, W., Pirmohamed, M., Park, K., & Naisbitt, D. (2010). Involvement of drug-specific CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T-cells in trimethoprim-mediated hepatitis. In IMMUNOLOGY Vol. 131 (pp. 120). Retrieved from https://www.webofscience.com/
Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in <i>p</i>-Phenylenediamine Allergic Patients and Tolerant Individuals
Coulter, E. M., Jenkinson, C., Farrell, J., Lavergne, S. N., Pease, C., White, A., . . . Naisbitt, D. J. (2010). Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in <i>p</i>-Phenylenediamine Allergic Patients and Tolerant Individuals. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130(1), 161-174. doi:10.1038/jid.2009.187
Stimulation of human T cells with sulfonamides and sulfonamide metabolites
Castrejon, J. L., Berry, N., El-Ghaiesh, S., Gerber, B., Pichler, W. J., Park, B. K., & Naisbitt, D. J. (2010). Stimulation of human T cells with sulfonamides and sulfonamide metabolites. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 125(2), 411-418. doi:10.1016/j.jaci.2009.10.031
Stimulation of sulfamethoxazole and sulfamethoxazole metabolite specific T-cells in patients with cystic fibrosis
Elsheikh, A., Callan, H., Monshi, M., Lavergne, S., Castrejon, J., El-Ghaiesh, S., . . . Naisbitt, D. J. (2010). Stimulation of sulfamethoxazole and sulfamethoxazole metabolite specific T-cells in patients with cystic fibrosis. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 70 (pp. 297). Retrieved from https://www.webofscience.com/
T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays
Martin, S. F., Esser, P. R., Schmucker, S., Dietz, L., Naisbitt, D. J., Park, B. K., . . . Sallusto, F. (2010). T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays. CELLULAR AND MOLECULAR LIFE SCIENCES, 67(24), 4171-4184. doi:10.1007/s00018-010-0495-3
TeloVac trial translational studies: investigation of the immune response to GV1001
Shaw, V., Naisbitt, D., Costello, E., Farrell, J., Park, B. K., Neoptolemos, J., & Middleton, G. (2010). TeloVac trial translational studies: investigation of the immune response to GV1001. In IMMUNOLOGY Vol. 131 (pp. 164). Retrieved from https://www.webofscience.com/
2009
"Danger" Conditions Increase Sulfamethoxazole-Protein Adduct Formation in Human Antigen-Presenting Cells
Lavergne, S. N., Wang, H., Callan, H. E., Park, B. K., & Naisbitt, D. J. (2009). "Danger" Conditions Increase Sulfamethoxazole-Protein Adduct Formation in Human Antigen-Presenting Cells. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 331(2), 372-381. doi:10.1124/jpet.109.155374
The role of metabolism in T-cell mediated drug hypersensitivity reactions
Naisbitt, D. (2009). The role of metabolism in T-cell mediated drug hypersensitivity reactions. TOXICOLOGY LETTERS, 189, S170-S171. doi:10.1016/j.toxlet.2009.06.698
Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1
Megherbi, R., Kiorpelidou, E., Foster, B., Rowe, C., Naisbitt, D. J., Goldring, C. E., & Park, B. K. (2009). Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1. Toxicology and Applied Pharmacology, 238(2), 120-132. doi:10.1016/j.taap.2009.05.001
Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1
Megherbi, R., Kiorpelidou, E., Foster, B., Rowe, C., Naisbitt, D. J., Goldring, C. E., & Park, B. K. (2009). Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1. TOXICOLOGY AND APPLIED PHARMACOLOGY, 238(2), 120-132. doi:10.1016/j.taap.2009.05.001
Involvement of drug-specific CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T-cells in trimethoprim-mediated hepatitis
El-Ghaiesh, S., Lavergne, S., Farell, J., Syn, W., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2009). Involvement of drug-specific CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T-cells in trimethoprim-mediated hepatitis. In TOXICOLOGY Vol. 262 (pp. 12). doi:10.1016/j.tox.2009.04.010
A Mechanistic Investigation into the Irreversible Protein Binding and Antigenicity of <i>p</i>-Phenylenediamine
Jenkinson, C., Jenkins, R. E., Maggs, J. L., Kitteringham, N. R., Aleksic, M., Park, B. K., & Naisbitt, D. J. (2009). A Mechanistic Investigation into the Irreversible Protein Binding and Antigenicity of <i>p</i>-Phenylenediamine. CHEMICAL RESEARCH IN TOXICOLOGY, 22(6), 1172-1180. doi:10.1021/tx900095r
Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation
Callan, H. E., Jenkins, R. E., Maggs, J. L., Lavergne, S. N., Clarke, S. E., Naisbitt, D. J., & Park, B. K. (2009). Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation. CHEMICAL RESEARCH IN TOXICOLOGY, 22(5), 937-948. doi:10.1021/tx900034r
Investigation of the immunogenicity of <i>p</i>-phenylenediamine and Bandrowski's base in the mouse
Farrell, J., Jenkinson, C., Lavergne, S. N., Maggs, J. L., Park, B. K., & Naisbitt, D. J. (2009). Investigation of the immunogenicity of <i>p</i>-phenylenediamine and Bandrowski's base in the mouse. TOXICOLOGY LETTERS, 185(3), 153-159. doi:10.1016/j.toxlet.2008.12.008
A pathological environment can modify sulfamethoxazole metabolism in human antigen presenting cells, including dendritic cells
Lavergne, S. N., Wang, H., Park, B. K., & Naisbitt, D. J. (2009). A pathological environment can modify sulfamethoxazole metabolism in human antigen presenting cells, including dendritic cells. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 293-294). Retrieved from https://www.webofscience.com/
Characterisation of p-phenylenediamine and Bandrowski's base-specific T-cell responses in the mouse.
Farrell, J., Jenkinson, C., Lavergne, S. N., Maggs, J. L., Park, B. K., & Naisbitt, D. J. (2009). Characterisation of p-phenylenediamine and Bandrowski's base-specific T-cell responses in the mouse.. Toxicol Lett., 185(153-15).
Characterization of SMX disposition in bone marrow-derived dendritic cells, as a part of a mouse model of SMX immunogenicity
Elsheikh, A., Lavergne, S. N., Sathish, J., Park, B. K., & Naisbitt, D. J. (2009). Characterization of SMX disposition in bone marrow-derived dendritic cells, as a part of a mouse model of SMX immunogenicity. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 287-288). Retrieved from https://www.webofscience.com/
Human antigen presenting cells can metabolize sulfamethoxazole to a protein reactive intermediate, leading to the formation of intracellular drug adducts that can stimulate drug specific T-cells from allergic patients
Lavergne, S. N., Wang, H., Castrejon, J. L., Park, B. K., & Naisbitt, D. J. (2009). Human antigen presenting cells can metabolize sulfamethoxazole to a protein reactive intermediate, leading to the formation of intracellular drug adducts that can stimulate drug specific T-cells from allergic patients. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 279). Retrieved from https://www.webofscience.com/
Measurement of lymphocyte proliferation and cytokine secretion from para-phenylenediamine allergic patients and tolerant individuals
Jenkinson, C., Aleksic, M., Lavergne, S. N., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2009). Measurement of lymphocyte proliferation and cytokine secretion from para-phenylenediamine allergic patients and tolerant individuals. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 280). Retrieved from https://www.webofscience.com/
Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP1
Megherbi, R., Kiorpelidou, E., Foster, B., Farrell, J., Rowe, C., Naisbitt, D. J., . . . Park, B. K. (2009). Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP1. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 292-293). Retrieved from https://www.webofscience.com/
Stimulation of antigen-specific T-cells from allergic patients with sulfonamides and sulfonamide metabolites
Casterjon, J. L., Jenkinson, C., Gerber, B. O., Pichler, W. J., Park, B. K., & Naisbitt, D. J. (2009). Stimulation of antigen-specific T-cells from allergic patients with sulfonamides and sulfonamide metabolites. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 289-290). Retrieved from https://www.webofscience.com/
Sulfamethoxazole metabolism by mouse splenocytes creates T-cell stimulatory hapten-protein complexes
Elsheikh, A., Castrejon, J. L., Lavergne, S. N., Park, B. K., & Naisbitt, D. J. (2009). Sulfamethoxazole metabolism by mouse splenocytes creates T-cell stimulatory hapten-protein complexes. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 288). Retrieved from https://www.webofscience.com/
The multiple adduction reactions of nitroso sulfamethoxazole with cysteinyl residues of peptides and proteins: Implications for hapten formation, structure and stability
Callan, H. E., Jenkins, R. E., Maggs, J. L., Lavergne, S. N., Naisbitt, D. J., & Park, B. K. (2009). The multiple adduction reactions of nitroso sulfamethoxazole with cysteinyl residues of peptides and proteins: Implications for hapten formation, structure and stability. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 288-289). Retrieved from https://www.webofscience.com/
2008
Nonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes: Implications for Bioanalysis of Sulfamethoxazole Metabolites
Sanderson, J. P., Hollis, F. J., Maggs, J. L., Clarke, S. E., Naisbitt, D. J., & Park, B. K. (2008). Nonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes: Implications for Bioanalysis of Sulfamethoxazole Metabolites. DRUG METABOLISM AND DISPOSITION, 36(12), 2424-2428. doi:10.1124/dmd.108.021246
The roles of drug metabolism in the pathogenesis of T-cell-mediated drug hypersensitivity
Lavergne, S. N., Park, B. K., & Naisbitt, D. J. (2008). The roles of drug metabolism in the pathogenesis of T-cell-mediated drug hypersensitivity. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 8(4), 299-307. doi:10.1097/ACI.0b013e3283079c64
Stimulation of nitroso sulfamethoxazole-specific T-cells with structurally-related hydroxylamine and nitroso metabolites
Castrejon, J. L., Farrell, J., O'neill, P. M., Park, B. K., & Naisbitt, D. J. (2008). Stimulation of nitroso sulfamethoxazole-specific T-cells with structurally-related hydroxylamine and nitroso metabolites. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 65(6), 997. Retrieved from https://www.webofscience.com/
<i>p</i>-Phenylenediamine-bound irreversibly to cysteine residues on human serum albumin activates T-cells from patients allergic to hair dye
Jenkinson, C., Jenkins, R. E., Pease, C. K., Kitteringham, N. R., Aleksic, M., Pirmohamed, M., . . . Naisbitt, D. J. (2008). <i>p</i>-Phenylenediamine-bound irreversibly to cysteine residues on human serum albumin activates T-cells from patients allergic to hair dye. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 984). Retrieved from https://www.webofscience.com/
A mechanistic investigation into the binding of PPD to a cysteine containing peptide and the model protein glutathione-<i>S</i>-transferase Pi
Jenkinson, C., Jenkins, R. E., Pease, C. K., Kitteringham, N. R., Aleksic, M., Naisbitt, D. J., & Park, B. K. (2008). A mechanistic investigation into the binding of PPD to a cysteine containing peptide and the model protein glutathione-<i>S</i>-transferase Pi. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 996-997). Retrieved from https://www.webofscience.com/
Activation of T-Cells from allergic patients and volunteers by <i>p</i>-phenylenediamine and Bandrowski's base
Coulter, E. M., Jenkinson, C., Wu, Y., Farrell, J., Foster, B., Smith, A., . . . Naisbitt, D. J. (2008). Activation of T-Cells from allergic patients and volunteers by <i>p</i>-phenylenediamine and Bandrowski's base. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 128(4), 897-905. doi:10.1038/sj.jid.5701071
Comparison of the functional characteristics of allergic and tolerant patient lymphocytes stimulated with <i>p</i>-phenylenediamine and Bandrowski's base
Coulter, E. M., Pease, C. K., White, A., Lockley, D., Basketter, D., Williams, D. P., . . . Naisbitt, D. J. (2008). Comparison of the functional characteristics of allergic and tolerant patient lymphocytes stimulated with <i>p</i>-phenylenediamine and Bandrowski's base. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 982-984). Retrieved from https://www.webofscience.com/
Enhancing CD8 T Cell immunity with Dendritic Cells Induced to Secrete Interleukin-2
Yeang, H. X. A., Naisbitt, D. J., Park, K., & Sathish, J. G. (2008). Enhancing CD8 T Cell immunity with Dendritic Cells Induced to Secrete Interleukin-2. In IMMUNOLOGY Vol. 125 (pp. 140-141). Retrieved from https://www.webofscience.com/
Investigation of the immunogenicity of p-phenylenediamine and Bandrowski's base
Farrell, J., Jenkinson, C., Coulter, E., Park, B. K., & Naisbitt, D. J. (2008). Investigation of the immunogenicity of p-phenylenediamine and Bandrowski's base. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 1000-1001). Retrieved from https://www.webofscience.com/
2007
Drugs as Haptens, Antigens, and Immunogens
Park, B. K., Sanderson, J. P., & Naisbitt, D. J. (2007). Drugs as Haptens, Antigens, and Immunogens. In Drug Hypersensitivity (pp. 55-65). KARGER. doi:10.1159/000104189
Drug hypersensitivity reactions in patients with HIV disease.
Pirmohamed, M., Drummond, N. S., Naisbitt, D. J., & Park, B. K. (2007). Drug hypersensitivity reactions in patients with HIV disease.. Expert review of clinical immunology, 3(3), 395-410. doi:10.1586/1744666x.3.3.395
Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling
Sanderson, J. P., Naisbitt, D. J., Farrell, J., Ashby, C. A., Tucker, M. J., Rieder, M. J., . . . Park, B. K. (2007). Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. JOURNAL OF IMMUNOLOGY, 178(9), 5533-5542. doi:10.4049/jimmunol.178.9.5533
Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling
Sanderson, J. P., Naisbitt, D. J., Farrell, J., Ashby, C. A., Tucker, M. J., Rieder, M. J., . . . Park, B. K. (2007). Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. Journal of Immunology, 178(9), 5533-5542.
Generation and characterization of antigen-specific CD4<SUP>+</SUP>, CD8<SUP>+</SUP>, and CD4<SUP>+</SUP>CD8<SUP>+</SUP> T-cell clones from patients with carbamazopine hypersensitivity
Wu, Y., Farrell, J., Pirmohmed, M., Park, B. K., & Naisbitt, D. J. (2007). Generation and characterization of antigen-specific CD4<SUP>+</SUP>, CD8<SUP>+</SUP>, and CD4<SUP>+</SUP>CD8<SUP>+</SUP> T-cell clones from patients with carbamazopine hypersensitivity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 119(4), 973-981. doi:10.1016/j.jaci.2006.12.617
Immunological principles of T-cell-mediated adverse drug reactions in skin
Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2007). Immunological principles of T-cell-mediated adverse drug reactions in skin. Expert Opinion on Drug Safety, 6(2), 109-124. doi:10.1517/14740338.6.2.109
Immunological principles of T-cell-mediated adverse drug reactions in skin
Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2007). Immunological principles of T-cell-mediated adverse drug reactions in skin. EXPERT OPINION ON DRUG SAFETY, 6(2), 109-124. doi:10.1517/14740338.6.2.109
Activation of human dendritic cells by <i>p</i>-phenylenediamine
Coulter, E. M., Farrell, J., Mathews, K. L., Maggs, J. L., Pease, C. K., Lockley, D. J., . . . Naisbitt, D. J. (2007). Activation of human dendritic cells by <i>p</i>-phenylenediamine. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 320(2), 885-892. doi:10.1124/jpet.106.113803
Investigation of the immunogenicity of diclofenac and diclofenac metabolites
Naisbitt, D. J., Sanderson, L. S., Meng, X., Stachulski, A. V., Clarke, S. E., & Park, B. K. (2007). Investigation of the immunogenicity of diclofenac and diclofenac metabolites. TOXICOLOGY LETTERS, 168(1), 45-50. doi:10.1016/j.toxlet.2006.10.014
Activation of T-cells from allergic patients and volunteers with p-phenylenediamine and Bandrowski's base
Coulter, E. M., Jenkinson, C., Wu, Y., Pease, C. K., Basketter, D. A., Friedmann, P. S., . . . Naisbitt, D. J. (2007). Activation of T-cells from allergic patients and volunteers with p-phenylenediamine and Bandrowski's base. J Invest Dermatol.
Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling
Sanderson, J. P., Naisbitt, D. J., Farrell, J., Ashby, C. A., Tucker, M. J., Rieder, M. J., . . . Park, B. K. (2007). Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. Journal of Immunology, 178(9), 5533-5542. Retrieved from http://www.jimmunol.org/cgi/reprint/178/9/5533
2006
The 2nd International Drug Hypersensitivity Meeting
Alfirevic, A., & Naisbitt, D. J. (2006). The 2nd International Drug Hypersensitivity Meeting. Expert Opinion on Drug Safety, 5(5), 729-734. doi:10.1517/14740338.5.5.729
The 2nd International Drug Hypersensitivity Meeting 18 - 21 April 2006, The University of Liverpool, Liverpool, UK.
Alfirevic, A., & Naisbitt, D. J. (2006). The 2nd International Drug Hypersensitivity Meeting 18 - 21 April 2006, The University of Liverpool, Liverpool, UK.. Expert opinion on drug safety, 5(5), 729-734. doi:10.1517/14740338.5.5.729
Systemic illness with skin eruption, fever and positive lymphocyte transformation test in a patient on irbesartan
Constable, S., Farrell, J., Naisbitt, D., King, C., Leonard, N., & Pirmohamed, M. (2006). Systemic illness with skin eruption, fever and positive lymphocyte transformation test in a patient on irbesartan. BRITISH JOURNAL OF DERMATOLOGY, 155(2), 491-493. doi:10.1111/j.1365-2133.2006.07338.x
Activation of T cells by carbamazepine and carbamazepine metabolites
Wu, Y., Sanderson, J. P., Farrell, J., Drummond, N. S., Hanson, A., Bowkett, E., . . . Naisbitt, D. J. (2006). Activation of T cells by carbamazepine and carbamazepine metabolites. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 118(1), 233-241. doi:10.1016/j.jaci.2006.03.005
Drug-specific T cells in an HIV-positive patient with nevirapine-induced hepatitis
Drummond, N. S., Vilar, F. J., Naisbitt, D. J., Hanson, A., Woods, A., Park, B. K., & Pirmohamed, M. (2006). Drug-specific T cells in an HIV-positive patient with nevirapine-induced hepatitis. ANTIVIRAL THERAPY, 11(3), 393-395. Retrieved from https://www.webofscience.com/
Role of bioactivation in drug-induced hypersensitivity reactions
Sanderson, J. P., Naisbitt, D. J., & Park, B. K. (2006). Role of bioactivation in drug-induced hypersensitivity reactions. AAPS JOURNAL, 8(1), E55-E64. doi:10.1208/aapsj080107
Characterization of cytotoxic CD8+T-cells from carbamazepine hypersensitive patients
Wu, Y., Farrell, J., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2006). Characterization of cytotoxic CD8+T-cells from carbamazepine hypersensitive patients. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 61 (pp. 632). Retrieved from https://www.webofscience.com/
Chemical and molecular investigation of hazard associated with drug bioactivation
Drummond, N. S., Gardner, I., Jones, R., Wood, T., Naisbitt, D. J., Owen, A., . . . Park, B. K. (2006). Chemical and molecular investigation of hazard associated with drug bioactivation. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 180-181). Retrieved from https://www.webofscience.com/
Dendritic cell metabolism of sulfamethoxazole leads to increased CD40 expression: a key determinant of immunogenicity
Sanderson, J. P., Naisbitt, D. J., Farrell, J., Drummond, N., Mathews, K. L., Pirmohamed, M., . . . Park, B. K. (2006). Dendritic cell metabolism of sulfamethoxazole leads to increased CD40 expression: a key determinant of immunogenicity. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 61 (pp. 645). Retrieved from https://www.webofscience.com/
Differential activation of lymphocytes from p-phenylenediamine sensitized patients and healthy volunteers
Coulter, E. M., Wu, Y., Farrell, J., Pease, C. K., Lockley, D. J., Basketter, D. A., . . . Naisbitt, D. J. (2006). Differential activation of lymphocytes from p-phenylenediamine sensitized patients and healthy volunteers. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 61 (pp. 639). Retrieved from https://www.webofscience.com/
Drug Hypersnesitivity Meeting, Liverpool, 2006
Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2006). Drug Hypersnesitivity Meeting, Liverpool, 2006. In 2nd International Drug Hypersnesitivity Meeting Vol. 38 (pp. 59). University Press: University Press.
Metabolism of sulphamethoxazole by dendritic cells: Implications for hypersensitivity
Sanderson, J. P., Naisbitt, D. J., Farrell, J., Drummond, N., Mathews, K. L., Pirmohamed, M., . . . Park, B. K. (2006). Metabolism of sulphamethoxazole by dendritic cells: Implications for hypersensitivity. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 182-183). Retrieved from https://www.webofscience.com/
The role of covalent binding in drug hypersensitivity
Sanderson, J. P., Naisbitt, D. J., & Park, B. K. (2006). The role of covalent binding in drug hypersensitivity. In W. J. Pichler (Ed.), Drug Hypersensitivity (pp. 460). Basel: Karger.
The second drug hypersensitivity meeting 18th - 21st April 2006, The University of Liverpool
Alfirevic, A., & Naisbitt, D. J. (2006). The second drug hypersensitivity meeting 18th - 21st April 2006, The University of Liverpool. Expert Opinion in Drug Safety, 5(5), 729-734.
2005
Errata
Errata (n.d.). International Journal of Clinical Practice, 59(11), 1371. doi:10.1111/j.1368-5031.2005.00729a.x
Investigation of toxic metabolites during drug development.
Park, K., Williams, D. P., Naisbitt, D. J., Kitteringham, N. R., & Pirmohamed, M. (2005). Investigation of toxic metabolites during drug development.. Toxicology and applied pharmacology, 207(2 Suppl), 425-434. doi:10.1016/j.taap.2005.02.029
Carbamazepine-induced acute liver failure as part of the DRESS syndrome
Syn, W. K., Naisbitt, D. J., Holt, A. P., Pirmohamed, M., & Mutimer, D. J. (2005). Carbamazepine-induced acute liver failure as part of the DRESS syndrome. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 59(8), 988-991. doi:10.1111/j.1368-5031.2005.00550.x
Characterization of the T-cell response in a patient with phenindione hypersensitivity
Naisbitt, D. J., Farrell, J., Chamberlain, P. J., Hopkins, J. E., Berry, N. G., Pirmohamed, M., & Park, B. K. (2005). Characterization of the T-cell response in a patient with phenindione hypersensitivity. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 313(3), 1058-1065. doi:10.1124/jpet.105.083758
Selective haptenation of cellular or extracellular protein by chemical allergens: Association with cytokine polarization
Hopkins, J. E., Naisbitt, D. J., Kitteringham, N. R., Dearman, R. J., Kimber, I., & Park, B. K. (2005). Selective haptenation of cellular or extracellular protein by chemical allergens: Association with cytokine polarization. CHEMICAL RESEARCH IN TOXICOLOGY, 18(2), 375-381. doi:10.1021/tx049688+
Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4<SUP>+</SUP> T-cells
Hopkins, J. E., Naisbitt, D. J., Humphreys, N., Dearman, R. J., Kimber, I., & Park, B. K. (2005). Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4<SUP>+</SUP> T-cells. TOXICOLOGY, 206(2), 221-231. doi:10.1016/j.tox.2004.08.010
Carbamazepine-induced acute liver failure as part of the DRESS syndrome (vol 59, pg 988, 2005)
Sun, W. K., Naisbitt, D. J., Holt, A. P., Primohamed, M., & Mutimer, D. J. (2005). Carbamazepine-induced acute liver failure as part of the DRESS syndrome (vol 59, pg 988, 2005). INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 59(11), 1371. doi:10.1111/j.1368-5031.2005.00729.x
Development of in vitro haptenation assays for skin sensitization through chemical and metabolic understanding
Pease, C. K. S., Divkovic, M., Payne, O., Vassallo, J. D., Coulter, E., Naisbitt, D. J., . . . Basketter, D. A. (2005). Development of in vitro haptenation assays for skin sensitization through chemical and metabolic understanding. In TOXICOLOGY LETTERS Vol. 158 (pp. S222-S223). Retrieved from https://www.webofscience.com/
Drug presentation to T cells
Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2005). Drug presentation to T cells. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 115(4), 876-877. doi:10.1016/j.jaci.2005.01.011
Drug-specific lymphocyte proliferation in an HIV-positive patient with nevirapine hepatitis
Drummond, N. S., Vilar, J., Naisbitt, D. J., Hanson, A., Park, B. K., & Pirmohamed, M. (2005). Drug-specific lymphocyte proliferation in an HIV-positive patient with nevirapine hepatitis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(5), 635-636. Retrieved from https://www.webofscience.com/
G-protein β3-subunit gene polymorphism and lymphocyte proliferation in carbamazepine hypersensitivity
Alfirevic, A., Naisbitt, D. J., Wu, Y., Farrell, J., Park, B. K., & Pirmohamed, M. (2005). G-protein β3-subunit gene polymorphism and lymphocyte proliferation in carbamazepine hypersensitivity. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(5), 645. Retrieved from https://www.webofscience.com/
2004
A chemically inert drug can stimulate T cells in vitro by their T cell receptor in non-sensitised individuals
Engler, O. B., Strasser, I., Naisbitt, D. J., Cerny, A., & Pichler, W. J. (2004). A chemically inert drug can stimulate T cells in vitro by their T cell receptor in non-sensitised individuals. TOXICOLOGY, 197(1), 47-56. doi:10.1016/j.tox.2003.12.008
Drug hypersensitivity reactions in skin: understanding mechanisms and the development of diagnostic and predictive tests
Naisbitt, D. J. (2004). Drug hypersensitivity reactions in skin: understanding mechanisms and the development of diagnostic and predictive tests. TOXICOLOGY, 194(3), 179-196. doi:10.1016/j.tox.2003.09.004
Characterization of T-cell responses in phenindione hypersensitivity
Naisbitt, D. J., Farrell, J., Chamberlain, P. J., Park, B. K., & Pirmohamed, M. (2004). Characterization of T-cell responses in phenindione hypersensitivity. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 57 (pp. 675). Retrieved from https://www.webofscience.com/
Characterization of drug-specific CD4<SUP>+</SUP> T-cells expressing the skin homing receptor CCR10 in lamotrigine hypersensitivity
Farrell, J., Gibney, C. A., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2004). Characterization of drug-specific CD4<SUP>+</SUP> T-cells expressing the skin homing receptor CCR10 in lamotrigine hypersensitivity. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 57 (pp. 690). Retrieved from https://www.webofscience.com/
Diagnosis of anticonvulsant hypersensitivity syndrome using an in vitro lymphocyte proliferation assay
Farrell, J., Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2004). Diagnosis of anticonvulsant hypersensitivity syndrome using an in vitro lymphocyte proliferation assay. In TOXICOLOGY Vol. 194 (pp. 255-256). Retrieved from https://www.webofscience.com/
Drug hypersensitivity reactions in the skin: Understanding mechanisms and the development of diagnostic and predictive tests
Naisbitt, D. J. (2004). Drug hypersensitivity reactions in the skin: Understanding mechanisms and the development of diagnostic and predictive tests. In TOXICOLOGY Vol. 194 (pp. 211-212). Retrieved from https://www.webofscience.com/
Drug-specific proliferation of lymphocytes from patients hypersensitive to carbamazepine and oxcarbazepine: cross-reactivity and possible clinical implications
Wu, Y., Farrell, J., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2004). Drug-specific proliferation of lymphocytes from patients hypersensitive to carbamazepine and oxcarbazepine: cross-reactivity and possible clinical implications. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 57 (pp. 683). Retrieved from https://www.webofscience.com/
T-cell recognition of carbamazepine and carbamazepine metabolites
Naisbitt, D. J., Wu, Y., Farrell, J., O'Neill, P. M., Pirmohamed, M., & Park, B. K. (2004). T-cell recognition of carbamazepine and carbamazepine metabolites. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 57(5), 669. Retrieved from https://www.webofscience.com/
2003
Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-Cell responses in animals and humans
Farrell, J., Naisbitt, D. J., Drummond, N. S., Depta, J. P. H., Vilar, F. J., Pirmohamed, M., & Park, B. K. (2003). Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-Cell responses in animals and humans. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 306(1), 229-237. doi:10.1124/jpet.103.050112
Characterization of drug-specific T cells in lamotrigine hypersensitivity
Naisbitt, D. J., Farrell, J., Wong, G., Depta, J. P. H., Dodd, C. C., Hopkins, J. E., . . . Park, B. K. (2003). Characterization of drug-specific T cells in lamotrigine hypersensitivity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 111(6), 1393-1403. doi:10.1067/mai.2003.1507
Hypersensitivity reactions to carbamazepine: Characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones
Naisbitt, D. J., Britschgi, M., Wong, G., Farrell, J., Depta, J. P. H., Chadwick, D. W., . . . Park, B. K. (2003). Hypersensitivity reactions to carbamazepine: Characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones. MOLECULAR PHARMACOLOGY, 63(3), 732-741. doi:10.1124/mol.63.3.732
Abacavir hypersensitivity in human immunodeficiency virus-positive patients:: demonstration of the presence of drug-specific lymphocyte proliferation <i>in vitro</i>
Dodd, C. C., Naisbitt, D. J., Vilar, F. J., Gordon, S. F., Maggs, J. L., Park, B. K., & Pirmohamed, M. (2003). Abacavir hypersensitivity in human immunodeficiency virus-positive patients:: demonstration of the presence of drug-specific lymphocyte proliferation <i>in vitro</i>. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 55 (pp. 421). Retrieved from https://www.webofscience.com/
Characterisation of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and man
Farrell, J., Naisbitt, D. J., Depta, J. P. H., Pichler, W. J., Pirmohamed, M., & Park, B. K. (2003). Characterisation of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and man. TOXICOLOGY, 192(1), 83-84. Retrieved from https://www.webofscience.com/
Characterization of lamotrigine-specific T cells from hypersensitive patients.
Naisbitt, D. J., Farrell, J., Hopkins, J. E., Wong, G., Pichler, W. J., Pirmohamed, M., & Park, K. (2003). Characterization of lamotrigine-specific T cells from hypersensitive patients.. In TOXICOLOGICAL SCIENCES Vol. 72 (pp. 52). Retrieved from https://www.webofscience.com/
Distribution of antigen formation: a determinant of the nature of a cellular immune response to simple chemicals
Hopkins, J. E., Naisbitt, D. J., Dearman, R. J., Kimber, I., & Park, B. K. (2003). Distribution of antigen formation: a determinant of the nature of a cellular immune response to simple chemicals. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 55 (pp. 444). Retrieved from https://www.webofscience.com/
Hypersensitivity reactions to lamotrigine: Characterization of drug-specific T-cell clones
Naisbitt, D. J., Farrell, J., Wong, G., Dodd, C. C., Hopkins, J. E., Depta, J. P. H., . . . Park, B. K. (2003). Hypersensitivity reactions to lamotrigine: Characterization of drug-specific T-cell clones. In TOXICOLOGY Vol. 192 (pp. 82-83). Retrieved from https://www.webofscience.com/
Immunopharmacology of hypersensitivity reactions to drugs
Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2003). Immunopharmacology of hypersensitivity reactions to drugs. CURRENT ALLERGY AND ASTHMA REPORTS, 3(1), 22-29. doi:10.1007/s11882-003-0006-9
Mechanisms of drug hypersensitivity in HIV-infected patients: the role of the immune system.
Vilar, F. J., Naisbitt, D. J., Park, B. K., & Pirmohamed, M. (2003). Mechanisms of drug hypersensitivity in HIV-infected patients: the role of the immune system.. Journal of HIV therapy, 8(2), 42-47.
The immunogenicity of diclofenac and its acyl glucuronide metabolite in the mouse <i>in vivo</i>
Kenny, J. R., Naisbitt, D. J., Stachulski, A. W., Hopkins, J. E., Dearman, R. J., Kimber, I., . . . Park, B. K. (2003). The immunogenicity of diclofenac and its acyl glucuronide metabolite in the mouse <i>in vivo</i>. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 55 (pp. 435). Retrieved from https://www.webofscience.com/
The relationship between cellular disposition and cytokine polarization for simple haptens.
Hopkins, J. E., Naisbitt, D. J., Dearman, R. J., Kimber, I., & Park, K. (2003). The relationship between cellular disposition and cytokine polarization for simple haptens.. In TOXICOLOGICAL SCIENCES Vol. 72 (pp. 54). Retrieved from https://www.webofscience.com/
2002
The danger hypothesis - potential role in idiosyncratic drug reactions
Pirmohamed, M., Naisbitt, D. J., Gordon, F., & Park, B. K. (2002). The danger hypothesis - potential role in idiosyncratic drug reactions. TOXICOLOGY, 181, 55-63. doi:10.1016/S0300-483X(02)00255-X
Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation
Naisbitt, D. J., Farrell, J., Gordon, S. F., Maggs, J. L., Burkhart, C., Pichler, W. J., . . . Park, B. K. (2002). Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation. MOLECULAR PHARMACOLOGY, 62(3), 628-637. doi:10.1124/mol.62.3.628
Are chemically reactive metabolites responsible for adverse reactions to drugs?
Williams, D. P., Kitteringham, N. R., Naisbitt, D. J., Pirmohamed, M., Smith, D. A., & Park, B. K. (2002). Are chemically reactive metabolites responsible for adverse reactions to drugs?. Current drug metabolism, 3(4), 351-366. doi:10.2174/1389200023337423
Toxicophores: Groups and metabolic routes associated with increased safety risk
Williams, D. P., & Naisbitt, D. J. (2002). Toxicophores: Groups and metabolic routes associated with increased safety risk. CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 5(1), 104-115. Retrieved from https://www.webofscience.com/
Anticonvulsant hypersensitivity syndrome: Methodology to investigate the role of metabolism and processing of carbamazepine to T-cells
Naisbitt, D. J., Depta, J., Wong, G., Farrell, J., Chadwick, D. W., Pichler, W. J., . . . Park, B. K. (2002). Anticonvulsant hypersensitivity syndrome: Methodology to investigate the role of metabolism and processing of carbamazepine to T-cells. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 53 (pp. 443P). Retrieved from https://www.webofscience.com/
Anticonvulsant hypersensitivity syndrome: characterization of the phenotype and cytokine profile of carabamazepine-specific T-cell clones
Naisbitt, D. J., Britschgi, M., Wong, G., Farrell, J., Chadwick, D. W., Pichler, W. J., . . . Park, B. K. (2002). Anticonvulsant hypersensitivity syndrome: characterization of the phenotype and cytokine profile of carabamazepine-specific T-cell clones. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 53 (pp. 418P-419P). Retrieved from https://www.webofscience.com/
Cellular and molecular pathophysiology of cutaneous drug reactions.
Pichler, W. J., Yawalkar, N., Britschgi, M., Depta, J., Strasser, I., Schmid, S., . . . Naisbitt, D. (2002). Cellular and molecular pathophysiology of cutaneous drug reactions.. American journal of clinical dermatology, 3(4), 229-238. doi:10.2165/00128071-200203040-00001
Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and MHC-restricted antigen presentation
Naisbitt, D. J., Farrell, J., Gordon, S. F., Maggs, J. L., Burkhart, C., Pichler, W. J., . . . Park, B. K. (2002). Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and MHC-restricted antigen presentation. Mol. Pharmacol., 62(3), 628-637. Retrieved from http://molpharm.aspetjournals.org/cgi/reprint/62/3/628?ck=nck
Exposure of mice to sulfamethoxazole metabolite stimulates interleukin 5 expression
Hopkins, J., Naisbitt, D. J., Humphreys, N., Dearman, R. J., Kimber, I., & Park, B. K. (2002). Exposure of mice to sulfamethoxazole metabolite stimulates interleukin 5 expression. In TOXICOLOGY Vol. 178 (pp. 41-42). Retrieved from https://www.webofscience.com/
MHC-restricted and processing dependent presentation of drug metabolite-modified cellular proteins to T-cells in the rat
Farrell, J., Gordon, S. F., Naisbitt, D. J., Gallimore, A., Burkhart, C., Pichler, W. J., . . . Park, B. K. (2002). MHC-restricted and processing dependent presentation of drug metabolite-modified cellular proteins to T-cells in the rat. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 53 (pp. 442P). Retrieved from https://www.webofscience.com/
2001
Metabolic activation in drug allergies
Park, B. K., Naisbitt, D. J., Gordon, S. F., Kitteringham, N. R., & Pirmohamed, M. (2001). Metabolic activation in drug allergies. TOXICOLOGY, 158(1-2), 11-23. doi:10.1016/S0300-483X(00)00397-8
Antigenicity and immunogenicity of sulphamethoxazole:: demonstration of metabolism-dependent haptenation and T-cell proliferation <i>in vivo</i>
Naisbitt, D. J., Gordon, S. F., Pirmohamed, M., Burkhart, C., Cribb, A. E., Pichler, W. J., & Park, B. K. (2001). Antigenicity and immunogenicity of sulphamethoxazole:: demonstration of metabolism-dependent haptenation and T-cell proliferation <i>in vivo</i>. BRITISH JOURNAL OF PHARMACOLOGY, 133(2), 295-305. doi:10.1038/sj.bjp.0704074
Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+T-cells
Burkhart, C., Von Greyerz, S., Depta, J. P. H., Naisbitt, D. J., Britschgi, M., Park, K. B., & Pichler, W. J. (2001). Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+T-cells. BRITISH JOURNAL OF PHARMACOLOGY, 132(3), 623-630. doi:10.1038/sj.bjp.0703845
Reactive metabolites and their role in drug reactions
Naisbitt, D. J., Williams, D. P., Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (2001). Reactive metabolites and their role in drug reactions. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 1(4), 317-325. Retrieved from https://www.webofscience.com/
The danger hypothesis: inflammation and idiosyncratic toxicity
Pirmohamed, M., Naisbitt, D. J., & Park, B. K. (2001). The danger hypothesis: inflammation and idiosyncratic toxicity. In TOXICOLOGY Vol. 164 (pp. 5). Retrieved from https://www.webofscience.com/
2000
Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection
Naisbitt, D. J., Vilar, F. J., Stalford, A. C., Wilkins, E. G. L., Pirmohamed, M., & Park, B. K. (2000). Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection. AIDS RESEARCH AND HUMAN RETROVIRUSES, 16(18), 1929-1938. doi:10.1089/088922200750054657
Metabolism of lamotrigine to a reactive arene oxide intermediate
Maggs, J. L., Naisbitt, D. J., Tettey, J. N. A., Pirmohamed, M., & Park, B. K. (2000). Metabolism of lamotrigine to a reactive arene oxide intermediate. CHEMICAL RESEARCH IN TOXICOLOGY, 13(11), 1075-1081. doi:10.1021/tx0000825
Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine
Williams, D. P., Pirmohamed, M., Naisbitt, D. J., Uetrecht, J. P., & Park, B. K. (2000). Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine. MOLECULAR PHARMACOLOGY, 58(1), 207-216. doi:10.1124/mol.58.1.207
Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4<SUP>+</SUP> T cells from allergic individuals
Schnyder, B., Burkhart, C., Schnyder-Frutig, K., von Greyerz, S., Naisbitt, D. J., Pirmohamed, M., . . . Pichler, W. J. (2000). Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4<SUP>+</SUP> T cells from allergic individuals. JOURNAL OF IMMUNOLOGY, 164(12), 6647-6654. doi:10.4049/jimmunol.164.12.6647
Immunological principles of adverse drug reactions - The initiation and propagation of immune responses elicited by drug treatment
Naisbitt, D. J., Gordon, S. F., Pirmohamed, M., & Park, B. K. (2000). Immunological principles of adverse drug reactions - The initiation and propagation of immune responses elicited by drug treatment. DRUG SAFETY, 23(6), 483-507. doi:10.2165/00002018-200023060-00002
Metabolism of lamotrigine to a reactive arene oxide intermediate
Maggs, J. L., Naisbitt, D. J., Tetty, J. N., Pirmohamed, M., & Park, B. K. (2000). Metabolism of lamotrigine to a reactive arene oxide intermediate. Chemical Research in Toxicology, 11(11), 1075-1081.
Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection.
Naisbitt, D. J., Vilar, F. J., Stalford, A. C., Wilkins, E. G., Pirmohamed, M., & Park, B. K. (2000). Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection.. AIDS research and human retroviruses, 16(18), 1926-1938.
1999
Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity
Naisbitt, D. J., Hough, S. J., Gill, H. J., Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (1999). Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity. BRITISH JOURNAL OF PHARMACOLOGY, 126(6), 1393-1407. doi:10.1038/sj.bjp.0702453
1998
Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs
Naisbitt, D. J., Williams, D. P., O'Neill, P. M., Maggs, J. L., Willock, D. J., Pirmohamed, M., & Park, B. K. (1998). Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs. CHEMICAL RESEARCH IN TOXICOLOGY, 11(12), 1586-1595. doi:10.1021/tx980148k
1997
Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: Possible role in agranulocytosis
Williams, D. P., Pirmohamed, M., Naisbitt, D. J., Maggs, J. L., & Park, B. K. (1997). Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: Possible role in agranulocytosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 283(3), 1375-1382. Retrieved from https://www.webofscience.com/
The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat
Gill, H. J., Hough, S. J., Naisbitt, D. J., Maggs, J. L., Kitteringham, N. R., Pirmohamed, M., & Park, B. K. (1997). The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 282(2), 795-801. Retrieved from https://www.webofscience.com/
Disposition of amodiaquine and related antimalarial agents in human neutrophils: Implications for drug design
Naisbitt, D. J., Ruscoe, J. E., Williams, D., ONeill, P. M., Pirmohamed, M., & Park, B. K. (1997). Disposition of amodiaquine and related antimalarial agents in human neutrophils: Implications for drug design. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 280(2), 884-893. Retrieved from https://www.webofscience.com/
1996
Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity.
Naisbitt, D. J., ONeill, P. M., Pirmohamed, M., & Park, B. K. (1996). Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 6(13), 1511-1516. doi:10.1016/S0960-894X(96)00260-0
Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component
Hawley, S. R., Bray, P. G., ONeill, P. M., Naisbitt, D. J., Park, B. K., & Ward, S. A. (1996). Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 40(10), 2345-2349. doi:10.1128/AAC.40.10.2345