Publications
Selected publications
- Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis (Journal article - 2022)
- Serpins in cartilage and osteoarthritis: what do we know? (Journal article - 2021)
- Collagenolytic matrix metalloproteinases antagonize proteinase-activated receptor-2 activation, providing insights into extracellular matrix turnover (Journal article - 2019)
- The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover (Journal article - 2017)
- Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms (Journal article - 2017)
2024
Domain Specific AI Segmentation of IMPDH2 Rod/Ring Structures in Mouse Embryonic Stem Cells
SERPINA3 is a marker of cartilage differentiation and is essential for the expression of extracellular matrix genes during early chondrogenesis.
Barter, M. J., Turner, D. A., Rice, S. J., Hines, M., Lin, H., Falconer, A. M. D., . . . Wilkinson, D. J. (2024). SERPINA3 is a marker of cartilage differentiation and is essential for the expression of extracellular matrix genes during early chondrogenesis.. Matrix biology : journal of the International Society for Matrix Biology, S0945-053X(24)00095-7. doi:10.1016/j.matbio.2024.07.004
EXPLOITING ACTIVITY-BASED PROBES TO IDENTIFY SERINE PROTEASE ACTIVITY IN OSTEOARTHRITIS
Hines, M., Wright, M., Bou-Gharios, G., Peffers, M., & Wilkinson, D. J. (2024). EXPLOITING ACTIVITY-BASED PROBES TO IDENTIFY SERINE PROTEASE ACTIVITY IN OSTEOARTHRITIS. Osteoarthritis and Cartilage, 32, S476. doi:10.1016/j.joca.2024.02.707
SERPINA3 (ALPHA-1 ANTICHYMOTRYPSIN) IS ESSENTIAL FOR EXTRACELLULAR MATRIX PRODUCTION DURING CARTILAGE FORMATION AND REGULATES THE CHONDROGENIC TRANSCRIPTION FACTOR SOX9
Barter, M. J., Turner, D. A., Rice, S. J., Hines, M., Lin, H., Falconer, A. M., . . . WILKINSON, D. J. (2024). SERPINA3 (ALPHA-1 ANTICHYMOTRYPSIN) IS ESSENTIAL FOR EXTRACELLULAR MATRIX PRODUCTION DURING CARTILAGE FORMATION AND REGULATES THE CHONDROGENIC TRANSCRIPTION FACTOR SOX9. Osteoarthritis and Cartilage, 32, S389. doi:10.1016/j.joca.2024.02.568
2022
The serine proteinase HtrA1 is ubiquitous and abundant in osteoarthritic joints, but what is it doing?
Wilkinson, D. J. (2022). The serine proteinase HtrA1 is ubiquitous and abundant in osteoarthritic joints, but what is it doing?. OSTEOARTHRITIS AND CARTILAGE, 30(8), 1015-1018. doi:10.1016/j.joca.2022.03.010
Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis
Wilkinson, D. J., Falconer, A. M. D., Wright, H. L., Lin, H., Yamamoto, K., Cheung, K., . . . Rowan, A. D. (2022). Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis. FEBS JOURNAL, 289(1), 121-139. doi:10.1111/febs.16127
2021
Joint tissue destruction and proteolysis
Wilkinson, D. J., & Young, D. A. (n.d.). Joint tissue destruction and proteolysis. In Rheumatology 8th Edition. Elsevier.
Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis
Yamamoto, K., Wilkinson, D., & Bou-Gharios, G. (n.d.). Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis. Calcified Tissue International. doi:10.1007/s00223-020-00739-7
Serpins in cartilage and osteoarthritis: what do we know?
Wilkinson, D. J. (2021). Serpins in cartilage and osteoarthritis: what do we know?. BIOCHEMICAL SOCIETY TRANSACTIONS, 49(2), 1013-1026. doi:10.1042/BST20201231
2019
British Society for Matrix Biology Spring 2019 Meeting: "Stroma, Niche, Repair".
British Society for Matrix Biology Spring 2019 Meeting: "Stroma, Niche, Repair". (2019). In International journal of experimental pathology Vol. 100 (pp. A1-A45). doi:10.1111/iep.12332
Collagenolytic matrix metalloproteinases antagonize proteinase-activated receptor-2 activation, providing insights into extracellular matrix turnover
Falconer, A. M. D., Chan, C. M., Gray, J., Nagashima, I., Holland, R. A., Shimizu, H., . . . Wilkinson, D. J. (2019). Collagenolytic matrix metalloproteinases antagonize proteinase-activated receptor-2 activation, providing insights into extracellular matrix turnover. JOURNAL OF BIOLOGICAL CHEMISTRY, 294(26), 10266-10277. doi:10.1074/jbc.RA119.006974
Recent advances in understanding the regulation of metalloproteinases.
Young, D. A., Barter, M. J., & Wilkinson, D. J. (2019). Recent advances in understanding the regulation of metalloproteinases.. F1000Research, 8, F1000 Faculty Rev-195. doi:10.12688/f1000research.17471.1
Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: implications for therapeutics
Wilkinson, D. J., Arques, M. D. C., Huesa, C., & Rowan, A. D. (2019). Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: implications for therapeutics. British journal of pharmacology, 176(1), 38-51. doi:10.1111/bph.14173
2018
Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to <i>MMP1</i> expression in human chondrocytes
Macdonald, C. D., Falconer, A. M. D., Chan, C. M., Wilkinson, D. J., Skelton, A., Reynard, L., . . . Rowan, A. D. (2018). Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to <i>MMP1</i> expression in human chondrocytes. PLOS ONE, 13(11). doi:10.1371/journal.pone.0207240
Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes
Baker, J., Falconer, A. M. D., Wilkinson, D. J., Europe-Finner, G. N., Litherland, G. J., & Rowan, A. D. (2018). Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes. PLOS ONE, 13(4). doi:10.1371/journal.pone.0195864
Tissue Destruction and Repair
Rowan, A., Young, D., & Wilkinson, D. J. (2018). Tissue Destruction and Repair. In Rheumatology 7th Edition. Elsevier.
2017
The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover
Wilkinson, D. J., Desilets, A., Lin, H., Charlton, S., Arques, M. D. C., Falconer, A., . . . Rowan, A. D. (2017). The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover. SCIENTIFIC REPORTS, 7. doi:10.1038/s41598-017-17028-3
Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms
Wilkinson, D. J., Habgood, A., Lamb, H. K., Thompson, P., Hawkins, A. R., Désilets, A., . . . Rowan, A. D. (2017). Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms. Arthritis & Rheumatology, 69(8), 1601-1611. doi:10.1002/art.40133
Cytokine-inducedMMP13Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) Regulation
Chan, C. M., Macdonald, C. D., Litherland, G. J., Wilkinson, D. J., Skelton, A., Europe-Finner, G. N., & Rowan, A. D. (2017). Cytokine-inducedMMP13Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) Regulation. Journal of Biological Chemistry, 292(5), 1625-1636. doi:10.1074/jbc.m116.756601
2015
Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination
Radwan, M., Wilkinson, D. J., Hui, W., Destrument, A. P. M., Charlton, S. H., Barter, M. J., . . . Young, D. A. (2015). Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination. Annals of the Rheumatic Diseases, 74, 1580-1587. doi:10.1136/annrheumdis-2013-204962
2014
Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis
Litherland, G. J., Hui, W., Elias, M. S., Wilkinson, D. J., Watson, S., Huesa, C., . . . Rowan, A. D. (2014). Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis. Arthritis & Rheumatology, 66(8), 2175-2187. doi:10.1002/art.38681
2012
IDENTIFYING THE KEY ENZYMES INVOLVED IN MATRIPTASE-INDUCED CARTILAGE AGGRECAN AND COLLAGEN RESORPTION
Wilkinson, D. J., Rowan, D., & Milner, J. (2012). IDENTIFYING THE KEY ENZYMES INVOLVED IN MATRIPTASE-INDUCED CARTILAGE AGGRECAN AND COLLAGEN RESORPTION. OSTEOARTHRITIS AND CARTILAGE, 20, S119-S120. doi:10.1016/j.joca.2012.02.146