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2024

Post-hospitalisation COVID-19 cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction.

Wood, G. K., Sargent, B. F., Ahmad, Z. -U. -A., Tharmaratnam, K., Dunai, C., Egbe, F. N., . . . Leek, E. C. (2024). Post-hospitalisation COVID-19 cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction.. Nature medicine. doi:10.1038/s41591-024-03309-8

DOI
10.1038/s41591-024-03309-8
Journal article

Preclinical evaluation and first-in-dog clinical trials of PBMC-expanded natural killer cells for adoptive immunotherapy in dogs with cancer.

Razmara, A. M., Farley, L. E., Harris, R. M., Judge, S. J., Lammers, M., Iranpur, K. R., . . . Canter, R. J. (2024). Preclinical evaluation and first-in-dog clinical trials of PBMC-expanded natural killer cells for adoptive immunotherapy in dogs with cancer.. Journal for immunotherapy of cancer, 12(4), e007963. doi:10.1136/jitc-2023-007963

DOI
10.1136/jitc-2023-007963
Journal article

Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.

Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2024). Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 15(1), 2918. doi:10.1038/s41467-024-47320-6

DOI
10.1038/s41467-024-47320-6
Journal article

Systemic immunostimulation induces glucocorticoid-mediated thymic involution succeeded by rebound hyperplasia which is impaired in aged recipients.

Collins, C. P., Khuat, L. T., Sckisel, G. D., Vick, L. V., Minnar, C. M., Dunai, C., . . . Murphy, W. J. (2024). Systemic immunostimulation induces glucocorticoid-mediated thymic involution succeeded by rebound hyperplasia which is impaired in aged recipients.. Frontiers in immunology, 15, 1429912. doi:10.3389/fimmu.2024.1429912

DOI
10.3389/fimmu.2024.1429912
Journal article

2023

421 Integrated analysis of natural killer cell-targeting, first-in-dog clinical trials by single-cell RNA sequencing

Razmara, A., Harris, R., Farley, L., Judge, S., Lammers, M., Dunai, C., . . . Canter, R. (2023). 421 Integrated analysis of natural killer cell-targeting, first-in-dog clinical trials by single-cell RNA sequencing. In Regular and Young Investigator Award Abstracts (pp. A470). BMJ Publishing Group Ltd. doi:10.1136/jitc-2023-sitc2023.0421

DOI
10.1136/jitc-2023-sitc2023.0421
Conference Paper

Intratumoral NKp46<sup>+</sup> natural killer cells are spatially distanced from T and MHC-I<sup>+</sup> cells with prognostic implications in soft tissue sarcoma.

Cruz, S. M., Sholevar, C. J., Judge, S. J., Darrow, M. A., Iranpur, K. R., Farley, L. E., . . . Canter, R. J. (2023). Intratumoral NKp46<sup>+</sup> natural killer cells are spatially distanced from T and MHC-I<sup>+</sup> cells with prognostic implications in soft tissue sarcoma.. Frontiers in immunology, 14, 1230534. doi:10.3389/fimmu.2023.1230534

DOI
10.3389/fimmu.2023.1230534
Journal article

Scientific Business Abstracts

Siew, K., Patel, V., Zimmermann, J., Vaughan, M., Cheshire, C., Kubik, A., . . . Leek, C. (n.d.). Scientific Business Abstracts. QJM: An International Journal of Medicine. doi:10.1093/qjmed/hcad072

DOI
10.1093/qjmed/hcad072
Journal article

Single cell and genomic profiling of PBMC-expanded NK cells in first-in-dog clinical trial of allogeneic adoptive NK cell therapy for dogs with cancer

Razmara, A., Farley, L., Harris, R., Judge, S., Lammers, M., Dunai, C., . . . Canter, R. (2023). Single cell and genomic profiling of PBMC-expanded NK cells in first-in-dog clinical trial of allogeneic adoptive NK cell therapy for dogs with cancer. The Journal of Immunology, 210(1_Supplement), 224.05. doi:10.4049/jimmunol.210.supp.224.05

DOI
10.4049/jimmunol.210.supp.224.05
Journal article

Systemic Cancer Immunostimulatory Therapies and Acute Viral Infection Induce Corticosteroid-Mediated Thymic Involution and Naïve T cell Output in Mice and Humans

Yoon, D. J., Khuat, L. T., Collins, C., Vick, L., Sckisel, G., Minnar, C. M., . . . Murphy, W. J. (2023). Systemic Cancer Immunostimulatory Therapies and Acute Viral Infection Induce Corticosteroid-Mediated Thymic Involution and Naïve T cell Output in Mice and Humans. The Journal of Immunology, 210(1_Supplement), 145.21. doi:10.4049/jimmunol.210.supp.145.21

DOI
10.4049/jimmunol.210.supp.145.21
Journal article

2022

Acute seizure risk in patients with encephalitis: development and validation of clinical prediction models from two independent prospective multicentre cohorts

Wood, G. K., Babar, R., Ellul, M. A., Thomas, R. H., Van Den Tooren, H., Easton, A., . . . Michael, B. D. (2022). Acute seizure risk in patients with encephalitis: development and validation of clinical prediction models from two independent prospective multicentre cohorts. BMJ Neurology Open, 4(2), e000323. doi:10.1136/bmjno-2022-000323

DOI
10.1136/bmjno-2022-000323
Journal article

Transcriptome Analysis of Tumor-Infiltrating Lymphocytes Identifies NK Cell Gene Signatures Associated With Lymphocyte Infiltration and Survival in Soft Tissue Sarcomas.

Judge, S. J., Bloomstein, J. D., Sholevar, C. J., Darrow, M. A., Stoffel, K. M., Vick, L. V., . . . Canter, R. J. (2022). Transcriptome Analysis of Tumor-Infiltrating Lymphocytes Identifies NK Cell Gene Signatures Associated With Lymphocyte Infiltration and Survival in Soft Tissue Sarcomas.. Frontiers in immunology, 13, 893177. doi:10.3389/fimmu.2022.893177

DOI
10.3389/fimmu.2022.893177
Journal article

Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response.

Rebhun, R. B., York, D., Cruz, S. M., Judge, S. J., Razmara, A. M., Farley, L. E., . . . Canter, R. J. (2022). Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response.. Journal for immunotherapy of cancer, 10(6), e004493. doi:10.1136/jitc-2022-004493

DOI
10.1136/jitc-2022-004493
Journal article

Acute seizure risk in encephalitis; analysis and modelling of 436 patients from two independent multi-centre cohorts (S38.008)

Wood, G., Ellul, M., Thomas, R., Easton, A., Burnside, G., Dunai, C., . . . Michael, B. (2022). Acute seizure risk in encephalitis; analysis and modelling of 436 patients from two independent multi-centre cohorts (S38.008). Neurology, 98(18_supplement). doi:10.1212/wnl.98.18_supplement.2600

DOI
10.1212/wnl.98.18_supplement.2600
Journal article

Acute seizure risk in encephalitis; analysis and modelling of 436 patients from two independent multi-centre cohorts

Wood, G., Ellul, M., Thomas, R., Easton, A., Burnside, G., Dunai, C., . . . Michael, B. (2022). Acute seizure risk in encephalitis; analysis and modelling of 436 patients from two independent multi-centre cohorts. In NEUROLOGY Vol. 98. Retrieved from https://www.webofscience.com/

Conference Paper

Killers on the loose: Immunotherapeutic strategies to improve NK cell-based therapy for cancer treatment

Dunai, C., Ames, E., Ochoa, M. C., Fernandez-Sendin, M., Melero, I., Simonetta, F., . . . Alvarez, M. (2022). Killers on the loose: Immunotherapeutic strategies to improve NK cell-based therapy for cancer treatment. In ADOPTIVE CELL TRANSFER (Vol. 370, pp. 65-122). doi:10.1016/bs.ircmb.2022.04.001

DOI
10.1016/bs.ircmb.2022.04.001
Chapter

2021

Increased efficacy of dual proinflammatory cytokine blockade on acute GVHD while maintaining GVT effects

Khuat, L. T., V. Vick, L., Dunai, C., Collins, C. P., More, S. K., Le, C. T., . . . Murphy, W. J. (2021). Increased efficacy of dual proinflammatory cytokine blockade on acute GVHD while maintaining GVT effects. BLOOD, 138(24), 2583-2588. doi:10.1182/blood.2021011216

DOI
10.1182/blood.2021011216
Journal article

Skin-Resident β2AR Signaling Delays Burn Wound Healing

Nguyen, A. V., Caryotakis, S. E., Wang, M., Gallegos, A., Bagood, M. D., Dunai, C., . . . Soulika, A. M. (2021). Skin-Resident β2AR Signaling Delays Burn Wound Healing. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 141(8), 2098-+. doi:10.1016/j.jid.2021.02.010

DOI
10.1016/j.jid.2021.02.010
Journal article

Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study

Ray, S. T. J., Abdel-Mannan, O., Sa, M., Fuller, C., Wood, G. K., Pysden, K., . . . Kneen, R. (2021). Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study. LANCET CHILD & ADOLESCENT HEALTH, 5(9), 631-641. doi:10.1016/S2352-4642(21)00193-0

DOI
10.1016/S2352-4642(21)00193-0
Journal article

NK cells and CD8 T cells in cancer immunotherapy: Similar functions by different mechanisms

Dunai, C., Collins, C. P., Barao, I., & Murphy, W. J. (2021). NK cells and CD8 T cells in cancer immunotherapy: Similar functions by different mechanisms. In Successes and Challenges of NK Immunotherapy (pp. 3-31). Elsevier. doi:10.1016/b978-0-12-824375-6.00001-1

DOI
10.1016/b978-0-12-824375-6.00001-1
Chapter

2020

Obesity induces gut microbiota alterations and augments acute graft-versus-host disease after allogeneic stem cell transplantation

Khuat, L. T., Le, C. T., Pai, C. -C. S., Shields-Cutler, R. R., Holtan, S. G., Rashidi, A., . . . Murphy, W. J. (2020). Obesity induces gut microbiota alterations and augments acute graft-versus-host disease after allogeneic stem cell transplantation. SCIENCE TRANSLATIONAL MEDICINE, 12(571). doi:10.1126/scitranslmed.aay7713

DOI
10.1126/scitranslmed.aay7713
Journal article

Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas.

Judge, S. J., Darrow, M. A., Thorpe, S. W., Gingrich, A. A., O'Donnell, E. F., Bellini, A. R., . . . Canter, R. J. (2020). Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas.. Journal for immunotherapy of cancer, 8(2), e001355. doi:10.1136/jitc-2020-001355

DOI
10.1136/jitc-2020-001355
Journal article

PD-1 Blockade Reverses Obesity-Mediated T Cell Priming Impairment

Le, C. T., Khuat, L. T., Caryotakis, S. E., Wang, M., Dunai, C., Nguyen, A. V., . . . Soulika, A. M. (2020). PD-1 Blockade Reverses Obesity-Mediated T Cell Priming Impairment. FRONTIERS IN IMMUNOLOGY, 11. doi:10.3389/fimmu.2020.590568

DOI
10.3389/fimmu.2020.590568
Journal article

Minimal PD-1 expression in mouse and human NK cells under diverse conditions

Judge, S. J., Dunai, C., Aguilar, E. G., Vick, S. C., Sturgill, I. R., Khuat, L. T., . . . Murphy, W. J. (2020). Minimal PD-1 expression in mouse and human NK cells under diverse conditions. JOURNAL OF CLINICAL INVESTIGATION, 130(6), 3051-3068. doi:10.1172/JCI33353

DOI
10.1172/JCI33353
Journal article

2019

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Wang, Z., Aguilar, E. G., Luna, J. I., Dunai, C., Khuat, L. T., Le, C. T., . . . Monjazeb, A. M. (2019). Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. NATURE MEDICINE, 25(1), 141-+. doi:10.1038/s41591-018-0221-5

DOI
10.1038/s41591-018-0221-5
Journal article

2018

NK cells for PD-1/PD-L1 blockade immunotherapy: pinning down the NK cell

Dunai, C., & Murphy, W. J. (2018). NK cells for PD-1/PD-L1 blockade immunotherapy: pinning down the NK cell. JOURNAL OF CLINICAL INVESTIGATION, 128(10), 4251-4253. doi:10.1172/JCI123121

DOI
10.1172/JCI123121
Journal article

2017

Licensing delineates helper and effector NK cell subsets during viral infection

Zamora, A. E., Aguilar, E. G., Sungur, C. M., Khuat, L. T., Dunai, C., Lochhead, G. R., . . . Murphy, W. J. (2017). Licensing delineates helper and effector NK cell subsets during viral infection. JCI INSIGHT, 2(10). doi:10.1172/jci.insight.87032

DOI
10.1172/jci.insight.87032
Journal article