Publications
2025
Post-hospitalisation COVID-19 cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction.
Wood, G. K., Sargent, B. F., Ahmad, Z. -U. -A., Tharmaratnam, K., Dunai, C., Egbe, F. N., . . . Leek, E. C. (2024). Post-hospitalisation COVID-19 cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction.. Nature medicine. doi:10.1038/s41591-024-03309-8
2024
Pulmonary SARS-CoV-2 infection leads to para-infectious immune activation in the brain
Dunai, C., Hetherington, C., Boardman, S. A., Clark, J. J., Sharma, P., Subramaniam, K., . . . Michael, B. D. (2024). Pulmonary SARS-CoV-2 infection leads to para-infectious immune activation in the brain. Frontiers in Immunology, 15. doi:10.3389/fimmu.2024.1440324
Diagnostic markers of acute encephalitis syndrome and COVID-associated multisystem inflammatory syndrome in children from Southern India.
Damodar, T., Dunai, C., Prabhu, N., Jose, M., Akhila, L., Kinhal, U. V., . . . Mani, R. S. (2024). Diagnostic markers of acute encephalitis syndrome and COVID-associated multisystem inflammatory syndrome in children from Southern India.. Journal of medical virology, 96(5), e29666. doi:10.1002/jmv.29666
Preclinical evaluation and first-in-dog clinical trials of PBMC-expanded natural killer cells for adoptive immunotherapy in dogs with cancer.
Razmara, A. M., Farley, L. E., Harris, R. M., Judge, S. J., Lammers, M., Iranpur, K. R., . . . Canter, R. J. (2024). Preclinical evaluation and first-in-dog clinical trials of PBMC-expanded natural killer cells for adoptive immunotherapy in dogs with cancer.. Journal for immunotherapy of cancer, 12(4), e007963. doi:10.1136/jitc-2023-007963
A rare case of opsoclonus myoclonus syndrome following COVID-19 illness.
Shil, R., Dunai, C., Seed, A., Wood, G., Collie, C., Pendered, S., . . . Michael, B. (2024). A rare case of opsoclonus myoclonus syndrome following COVID-19 illness.. Clinical medicine (London, England), 23 Suppl 6, 40. doi:10.7861/clinmed.23-6-s40
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2024). Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 15(1), 2918. doi:10.1038/s41467-024-47320-6
Editorial: Immune studies of SARS-CoV2 and vaccines using preclinical modeling.
Dunai, C., Iyer, S. S., & Murphy, W. J. (2024). Editorial: Immune studies of SARS-CoV2 and vaccines using preclinical modeling.. Frontiers in immunology, 15, 1548624. doi:10.3389/fimmu.2024.1548624
Systemic immunostimulation induces glucocorticoid-mediated thymic involution succeeded by rebound hyperplasia which is impaired in aged recipients.
Collins, C. P., Khuat, L. T., Sckisel, G. D., Vick, L. V., Minnar, C. M., Dunai, C., . . . Murphy, W. J. (2024). Systemic immunostimulation induces glucocorticoid-mediated thymic involution succeeded by rebound hyperplasia which is impaired in aged recipients.. Frontiers in immunology, 15, 1429912. doi:10.3389/fimmu.2024.1429912
2023
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2023). Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 14(1), 8487. doi:10.1038/s41467-023-42320-4
421 Integrated analysis of natural killer cell-targeting, first-in-dog clinical trials by single-cell RNA sequencing
Razmara, A., Harris, R., Farley, L., Judge, S., Lammers, M., Dunai, C., . . . Canter, R. (2023). 421 Integrated analysis of natural killer cell-targeting, first-in-dog clinical trials by single-cell RNA sequencing. In Regular and Young Investigator Award Abstracts (pp. A470). BMJ Publishing Group Ltd. doi:10.1136/jitc-2023-sitc2023.0421
A rare case of opsoclonus myoclonus syndrome following COVID-19 illness.
Shil, R., Dunai, C., Seed, A., Wood, G., Collie, C., Pendered, S., . . . Michael, B. (2023). A rare case of opsoclonus myoclonus syndrome following COVID-19 illness.. Clinical medicine (London, England), 23(Suppl 6), 40. doi:10.7861/clinmed.23-6-s40
Regulation of human and mouse bystander T cell activation responses by PD-1
Le, C. T., Vick, L. V., Collins, C., Dunai, C., Sheng, M. K., Khuat, L. T., . . . Murphy, W. J. (2023). Regulation of human and mouse bystander T cell activation responses by PD-1. JCI INSIGHT, 8(18). doi:10.1172/jci.insight.173287
Intratumoral NKp46<sup>+</sup> natural killer cells are spatially distanced from T and MHC-I<sup>+</sup> cells with prognostic implications in soft tissue sarcoma.
Cruz, S. M., Sholevar, C. J., Judge, S. J., Darrow, M. A., Iranpur, K. R., Farley, L. E., . . . Canter, R. J. (2023). Intratumoral NKp46<sup>+</sup> natural killer cells are spatially distanced from T and MHC-I<sup>+</sup> cells with prognostic implications in soft tissue sarcoma.. Frontiers in immunology, 14, 1230534. doi:10.3389/fimmu.2023.1230534
Scientific Business Abstracts
Siew, K., Patel, V., Zimmermann, J., Vaughan, M., Cheshire, C., Kubik, A., . . . Leek, C. (n.d.). Scientific Business Abstracts. QJM: An International Journal of Medicine. doi:10.1093/qjmed/hcad072
PD-1 signaling serves a dual role in suppressing T cell activation but also in protecting from activation-induced cell death
Vick, L. V., Khuat, L. T., Le, C., Dunai, C., Collins, C., Canter, R., . . . Murphy, W. J. (2023). PD-1 signaling serves a dual role in suppressing T cell activation but also in protecting from activation-induced cell death. The Journal of Immunology, 210(Supplement_1), 226.11. doi:10.4049/jimmunol.210.supp.226.11
Single cell and genomic profiling of PBMC-expanded NK cells in first-in-dog clinical trial of allogeneic adoptive NK cell therapy for dogs with cancer
Razmara, A., Farley, L., Harris, R., Judge, S., Lammers, M., Dunai, C., . . . Canter, R. (2023). Single cell and genomic profiling of PBMC-expanded NK cells in first-in-dog clinical trial of allogeneic adoptive NK cell therapy for dogs with cancer. The Journal of Immunology, 210(Supplement_1), 224.05. doi:10.4049/jimmunol.210.supp.224.05
Systemic Cancer Immunostimulatory Therapies and Acute Viral Infection Induce Corticosteroid-Mediated Thymic Involution and Naïve T cell Output in Mice and Humans
Yoon, D. J., Khuat, L. T., Collins, C., Vick, L., Sckisel, G., Minnar, C. M., . . . Murphy, W. J. (2023). Systemic Cancer Immunostimulatory Therapies and Acute Viral Infection Induce Corticosteroid-Mediated Thymic Involution and Naïve T cell Output in Mice and Humans. The Journal of Immunology, 210(Supplement_1), 145.21. doi:10.4049/jimmunol.210.supp.145.21
Aging augments obesity-induced thymic involution and peripheral T cell exhaustion altering the "obesity paradox"
Vick, L. V. V., Collins, C. P. P., Khuat, L. T. T., Wang, Z., Dunai, C., Aguilar, E. G. G., . . . Murphy, W. J. J. (2023). Aging augments obesity-induced thymic involution and peripheral T cell exhaustion altering the "obesity paradox". FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.1012016
2022
Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses
Needham, E. J., Ren, A. L., Digby, R. J., Norton, E. J., Ebrahimi, S., Outtrim, J. G., . . . Menon, D. K. (2022). Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses. BRAIN, 145(11), 4097-4107. doi:10.1093/brain/awac321
272 Pre-clinical evaluation and first-in-dog clinical trials of intravenous infusion of PBMC-expanded adoptive NK cell therapy in dogs with cancer
Razmara, A., Farley, L., Harris, R., Judge, S., Lammers, M., Dunai, C., . . . Canter, R. (2022). 272 Pre-clinical evaluation and first-in-dog clinical trials of intravenous infusion of PBMC-expanded adoptive NK cell therapy in dogs with cancer. In Regular and Young Investigator Award Abstracts (pp. A287). BMJ Publishing Group Ltd. doi:10.1136/jitc-2022-sitc2022.0272
520 PD-1 Inhibits Bystander T Cell Activation and Protects from Activation Induced Cell Death
Sheng, M., Le, C., Dunai, C., Khuat, L., Vick, L., Stoffel, K., . . . Murphy, W. (2022). 520 PD-1 Inhibits Bystander T Cell Activation and Protects from Activation Induced Cell Death. In Regular and Young Investigator Award Abstracts (pp. A545). BMJ Publishing Group Ltd. doi:10.1136/jitc-2022-sitc2022.0520
534 Sex-linked differences in obesity markedly impact the anti-tumor efficacy of PD-1 blockade
Vick, L., Wang, Z., Collins, C., Khuat, L., Dunai, C., Stoffel, K., . . . Murphy, W. (2022). 534 Sex-linked differences in obesity markedly impact the anti-tumor efficacy of PD-1 blockade. In Regular and Young Investigator Award Abstracts (pp. A560). BMJ Publishing Group Ltd. doi:10.1136/jitc-2022-sitc2022.0534
Acute seizure risk in patients with encephalitis: development and validation of clinical prediction models from two independent prospective multicentre cohorts
Wood, G. K., Babar, R., Ellul, M. A., Thomas, R. H., Van Den Tooren, H., Easton, A., . . . Michael, B. D. (2022). Acute seizure risk in patients with encephalitis: development and validation of clinical prediction models from two independent prospective multicentre cohorts. BMJ Neurology Open, 4(2), e000323. doi:10.1136/bmjno-2022-000323
Transcriptome Analysis of Tumor-Infiltrating Lymphocytes Identifies NK Cell Gene Signatures Associated With Lymphocyte Infiltration and Survival in Soft Tissue Sarcomas.
Judge, S. J., Bloomstein, J. D., Sholevar, C. J., Darrow, M. A., Stoffel, K. M., Vick, L. V., . . . Canter, R. J. (2022). Transcriptome Analysis of Tumor-Infiltrating Lymphocytes Identifies NK Cell Gene Signatures Associated With Lymphocyte Infiltration and Survival in Soft Tissue Sarcomas.. Frontiers in immunology, 13, 893177. doi:10.3389/fimmu.2022.893177
Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response.
Rebhun, R. B., York, D., Cruz, S. M., Judge, S. J., Razmara, A. M., Farley, L. E., . . . Canter, R. J. (2022). Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response.. Journal for immunotherapy of cancer, 10(6), e004493. doi:10.1136/jitc-2022-004493
Immune-Mediated Mechanisms of COVID-19 Neuropathology
Dunai, C., Collie, C., & Michael, B. D. (2022). Immune-Mediated Mechanisms of COVID-19 Neuropathology. FRONTIERS IN NEUROLOGY, 13. doi:10.3389/fneur.2022.882905
Acute seizure risk in encephalitis; analysis and modelling of 436 patients from two independent multi-centre cohorts (S38.008)
Wood, G., Ellul, M., Thomas, R., Easton, A., Burnside, G., Dunai, C., . . . Michael, B. (2022). Acute seizure risk in encephalitis; analysis and modelling of 436 patients from two independent multi-centre cohorts (S38.008). Neurology, 98(18_supplement). doi:10.1212/wnl.98.18_supplement.2600
Characterization of the Tumor Immune Microenvironment in Soft Tissue Sarcoma Patients Undergoing Surgery
Cruz, S. M., Judge, S. J., Darrow, M. A., Perry, L. M., Farley, L. E., Iranpur, K. R., . . . Canter, R. J. (2022). Characterization of the Tumor Immune Microenvironment in Soft Tissue Sarcoma Patients Undergoing Surgery. The Journal of Immunology, 208(Supplement_1), 62.05. doi:10.4049/jimmunol.208.supp.62.05
Optimization of expansion techniques for adoptive NK cell transfer in dogs with cancer
Razmara, A., Judge, S. J., Dunai, C., Murphy, W. J., Rebhun, R. B., Kent, M. S., & Canter, R. J. (2022). Optimization of expansion techniques for adoptive NK cell transfer in dogs with cancer. The Journal of Immunology, 208(Supplement_1), 124.02. doi:10.4049/jimmunol.208.supp.124.02
Tissue resident lung natural killer (NK) cells demonstrate enhanced responses to IL-15 compared to peripheral populations
Sholevar, C., Judge, S. J., Nielsen, R., Farley, L. E., Dunai, C., Razmara, A. M., . . . Canter, R. J. (2022). Tissue resident lung natural killer (NK) cells demonstrate enhanced responses to IL-15 compared to peripheral populations. The Journal of Immunology, 208(Supplement_1), 165.09. doi:10.4049/jimmunol.208.supp.165.09
Acute seizure risk in encephalitis; analysis and modelling of 436 patients from two independent multi-centre cohorts
Wood, G., Ellul, M., Thomas, R., Easton, A., Burnside, G., Dunai, C., . . . Michael, B. (2022). Acute seizure risk in encephalitis; analysis and modelling of 436 patients from two independent multi-centre cohorts. In NEUROLOGY Vol. 98. Retrieved from https://www.webofscience.com/
Killers on the loose: Immunotherapeutic strategies to improve NK cell-based therapy for cancer treatment
Dunai, C., Ames, E., Ochoa, M. C., Fernandez-Sendin, M., Melero, I., Simonetta, F., . . . Alvarez, M. (2022). Killers on the loose: Immunotherapeutic strategies to improve NK cell-based therapy for cancer treatment. In ADOPTIVE CELL TRANSFER (Vol. 370, pp. 65-122). doi:10.1016/bs.ircmb.2022.04.001
2021
Increased efficacy of dual proinflammatory cytokine blockade on acute GVHD while maintaining GVT effects
Khuat, L. T., V. Vick, L., Dunai, C., Collins, C. P., More, S. K., Le, C. T., . . . Murphy, W. J. (2021). Increased efficacy of dual proinflammatory cytokine blockade on acute GVHD while maintaining GVT effects. BLOOD, 138(24), 2583-2588. doi:10.1182/blood.2021011216
Brain Injury in COVID-19 is Associated with Autoinflammation and Autoimmunity
Activation status dictates the function of unlicensed natural killer cells in mice and humans
Aguilar, E. G., Dunai, C., Judge, S. J., Zamora, A. E., Khuat, L. T., Vick, L. V., . . . Murphy, W. J. (2021). Activation status dictates the function of unlicensed natural killer cells in mice and humans. BLOOD ADVANCES, 5(20), 4219-4232. doi:10.1182/bloodadvances.2021004589
Mechanisms by Which Obesity Promotes Acute Graft-<i>Versus</i>-Host Disease in Mice.
Khuat, L. T., Vick, L. V., Choi, E., Dunai, C., Merleev, A. A., Maverakis, E., . . . Murphy, W. J. (2021). Mechanisms by Which Obesity Promotes Acute Graft-<i>Versus</i>-Host Disease in Mice.. Frontiers in immunology, 12, 752484. doi:10.3389/fimmu.2021.752484
Editorial: Targeting the Chemoattractant System in Inflammation
Hosoya, T., Cordelia, D., Michael, B. D., Miyabe, C., Nagai, J., Murooka, T. T., & Miyabe, Y. (2021). Editorial: Targeting the Chemoattractant System in Inflammation. FRONTIERS IN PHARMACOLOGY, 12. doi:10.3389/fphar.2021.744290
Skin-Resident β2AR Signaling Delays Burn Wound Healing
Nguyen, A. V., Caryotakis, S. E., Wang, M., Gallegos, A., Bagood, M. D., Dunai, C., . . . Soulika, A. M. (2021). Skin-Resident β2AR Signaling Delays Burn Wound Healing. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 141(8), 2098-+. doi:10.1016/j.jid.2021.02.010
Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study
Ray, S. T. J., Abdel-Mannan, O., Sa, M., Fuller, C., Wood, G. K., Pysden, K., . . . Kneen, R. (2021). Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study. LANCET CHILD & ADOLESCENT HEALTH, 5(9), 631-641. doi:10.1016/S2352-4642(21)00193-0
Gene expression analysis of sarcoma-infiltrating NK cells identifies signatures correlating with favorable prognosis and potential new targets for augmenting NK function
Judge, S. J., Dunai, C., Razmara, A., Cruz, S. M., & Canter, R. J. (2021). Gene expression analysis of sarcoma-infiltrating NK cells identifies signatures correlating with favorable prognosis and potential new targets for augmenting NK function. The Journal of Immunology, 206(1_Supplement), 57.12. doi:10.4049/jimmunol.206.supp.57.12
Mouse Preclinical Cancer Immunotherapy Modeling Involving Anti-PD-1 Therapies Reveals the Need to Use Mouse Reagents to Mirror Clinical Paradigms.
Monjazeb, A. M., Wang, Z., Vick, L. V., Dunai, C., Minnar, C., Khuat, L. T., & Murphy, W. J. (2021). Mouse Preclinical Cancer Immunotherapy Modeling Involving Anti-PD-1 Therapies Reveals the Need to Use Mouse Reagents to Mirror Clinical Paradigms.. Cancers, 13(4), 729. doi:10.3390/cancers13040729
Chapter 1 NK cells and CD8 T cells in cancer immunotherapy: Similar functions by different mechanisms
Dunai, C., Collins, C. P., Barao, I., & Murphy, W. J. (2021). Chapter 1 NK cells and CD8 T cells in cancer immunotherapy: Similar functions by different mechanisms. In Successes and Challenges of NK Immunotherapy (pp. 3-31). Elsevier. doi:10.1016/b978-0-12-824375-6.00001-1
NK cells and CD8 T cells in cancer immunotherapy: Similar functions by different mechanisms
Dunai, C., Collins, C. P., Barao, I., & Murphy, W. J. (2021). NK cells and CD8 T cells in cancer immunotherapy: Similar functions by different mechanisms. In Successes and Challenges of NK Immunotherapy (pp. 3-31). Elsevier. doi:10.1016/b978-0-12-824375-6.00001-1
2020
Obesity induces gut microbiota alterations and augments acute graft-versus-host disease after allogeneic stem cell transplantation
Khuat, L. T., Le, C. T., Pai, C. -C. S., Shields-Cutler, R. R., Holtan, S. G., Rashidi, A., . . . Murphy, W. J. (2020). Obesity induces gut microbiota alterations and augments acute graft-versus-host disease after allogeneic stem cell transplantation. SCIENCE TRANSLATIONAL MEDICINE, 12(571). doi:10.1126/scitranslmed.aay7713
Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas.
Judge, S. J., Darrow, M. A., Thorpe, S. W., Gingrich, A. A., O'Donnell, E. F., Bellini, A. R., . . . Canter, R. J. (2020). Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas.. Journal for immunotherapy of cancer, 8(2), e001355. doi:10.1136/jitc-2020-001355
503 Tumor infiltrating lymphocytes in soft tissue sarcomas upregulate the exhaustion marker TIGIT and are reinvigorated by IL-15 stimulation and TIGIT blockade
Judge, S., Darrow, M., Thorpe, S., Gingrich, A., O’Donnell, E., Bellini, A., . . . Canter, R. (2020). 503 Tumor infiltrating lymphocytes in soft tissue sarcomas upregulate the exhaustion marker TIGIT and are reinvigorated by IL-15 stimulation and TIGIT blockade. In Regular and young investigator award abstracts (pp. A309.2-A309). BMJ Publishing Group Ltd. doi:10.1136/jitc-2020-sitc2020.0503
IL-2 and Anti-TGF-β Promote NK Cell Reconstitution and Anti-tumor Effects after Syngeneic Hematopoietic Stem Cell Transplantation.
Alvarez, M., Dunai, C., Khuat, L. T., Aguilar, E. G., Barao, I., & Murphy, W. J. (2020). IL-2 and Anti-TGF-β Promote NK Cell Reconstitution and Anti-tumor Effects after Syngeneic Hematopoietic Stem Cell Transplantation.. Cancers, 12(11), E3189. doi:10.3390/cancers12113189
PD-1 Blockade Reverses Obesity-Mediated T Cell Priming Impairment
Le, C. T., Khuat, L. T., Caryotakis, S. E., Wang, M., Dunai, C., Nguyen, A. V., . . . Soulika, A. M. (2020). PD-1 Blockade Reverses Obesity-Mediated T Cell Priming Impairment. FRONTIERS IN IMMUNOLOGY, 11. doi:10.3389/fimmu.2020.590568
Minimal PD-1 expression in mouse and human NK cells under diverse conditions
Judge, S. J., Dunai, C., Aguilar, E. G., Vick, S. C., Sturgill, I. R., Khuat, L. T., . . . Murphy, W. J. (2020). Minimal PD-1 expression in mouse and human NK cells under diverse conditions. JOURNAL OF CLINICAL INVESTIGATION, 130(6), 3051-3068. doi:10.1172/JCI33353
Differences in NK and Memory CD8 T cell responses to antigen-nonspecific stimulation by interleukin-15
Judge, S. J., Dunai, C., Le, C. T., Khuat, L. T., Vick, L. V., Stoffel, K. M., . . . Murphy, W. J. (2020). Differences in NK and Memory CD8 T cell responses to antigen-nonspecific stimulation by interleukin-15. The Journal of Immunology, 204(1_Supplement), 148.17. doi:10.4049/jimmunol.204.supp.148.17
2019
Obesity-Induced Microbiome Alterations Result in Severe Gastrointestinal Graft-Versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation
Khuat, L. T., Le, C. T., Pai, C. -C., Shields-Cutler, R., Holtan, S., Rashidi, A., . . . Murphy, W. J. (2019). Obesity-Induced Microbiome Alterations Result in Severe Gastrointestinal Graft-Versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation. Blood, 134(Supplement_1), 1922. doi:10.1182/blood-2019-127743
Adiposity augments toxicity of mouse cytomegalovirus
Wang, Z., Dunai, C., Le, C., & Murphy, W. J. (2019). Adiposity augments toxicity of mouse cytomegalovirus. The Journal of Immunology, 202(1_Supplement), 197.12. doi:10.4049/jimmunol.202.supp.197.12
PD-1 is not expressed on highly activated Natural Killer cells in human and murine models
Judge, S. J., Dunai, C., Sturgill, I., Stoffel, K., Darrow, M., Canter, R., & Murphy, W. J. (2019). PD-1 is not expressed on highly activated Natural Killer cells in human and murine models. The Journal of Immunology, 202(1_Supplement), 126.27. doi:10.4049/jimmunol.202.supp.126.27
PD-1 regulates response to bystander activation of memory CD8 T cells
Le, C., Dunai, C., Khuat, L. T., & Murphy, W. J. (2019). PD-1 regulates response to bystander activation of memory CD8 T cells. The Journal of Immunology, 202(1_Supplement), 56.17. doi:10.4049/jimmunol.202.supp.56.17
The effect of mouse cytomegalovirus infection on natural killer cell development following hematopoietic stem cell transplant
Dunai, C., Aguilar, E. G., Khuat, L. T., Le, C. T., Wang, Z., Stoffel, K. M., & Murphy, W. J. (2019). The effect of mouse cytomegalovirus infection on natural killer cell development following hematopoietic stem cell transplant. The Journal of Immunology, 202(1_Supplement), 69.36. doi:10.4049/jimmunol.202.supp.69.36
Assessment of PD-1 expression in human resting and activated natural killer cells and murine tumor models.
Judge, S. J., Dunai, C., Sturgill, I. R., Stoffel, K. M., Murphy, W. J., & Canter, R. J. (2019). Assessment of PD-1 expression in human resting and activated natural killer cells and murine tumor models.. Journal of Clinical Oncology, 37(8_suppl), 36. doi:10.1200/jco.2019.37.8_suppl.36
Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade
Wang, Z., Aguilar, E. G., Luna, J. I., Dunai, C., Khuat, L. T., Le, C. T., . . . Monjazeb, A. M. (2019). Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. NATURE MEDICINE, 25(1), 141-+. doi:10.1038/s41591-018-0221-5
2018
NK cells for PD-1/PD-L1 blockade immunotherapy: pinning down the NK cell
Dunai, C., & Murphy, W. J. (2018). NK cells for PD-1/PD-L1 blockade immunotherapy: pinning down the NK cell. JOURNAL OF CLINICAL INVESTIGATION, 128(10), 4251-4253. doi:10.1172/JCI123121
1455 Cutaneous wounds healed at the cost of overall fitness in the aged Balb/C mouse model
Bagood, M. D., Khuat, L., So, M., Dunai, C., Murphy, W., & Isseroff, R. (2018). 1455 Cutaneous wounds healed at the cost of overall fitness in the aged Balb/C mouse model. Journal of Investigative Dermatology, 138(5), S247. doi:10.1016/j.jid.2018.03.1473
Diet-induced obesity impairs induction of Experimental Autoimmune Encephalomyelitis and is restored by PD-1 blockade
Le, C., Khuat, L. T., Dunai, C., Soulika, A., & Murphy, W. J. (2018). Diet-induced obesity impairs induction of Experimental Autoimmune Encephalomyelitis and is restored by PD-1 blockade. The Journal of Immunology, 200(Supplement_1), 163.23. doi:10.4049/jimmunol.200.supp.163.23
Obesity results in marked increases in gut permeability, inflammatory cytokines, and acute gut graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
Khuat, L. T., Pai, C. -C. S., Le, C. T., Dunai, C., Chen, M., Raybould, H. E., . . . Murphy, W. J. (2018). Obesity results in marked increases in gut permeability, inflammatory cytokines, and acute gut graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.. The Journal of Immunology, 200(Supplement_1), 55.3. doi:10.4049/jimmunol.200.supp.55.3
Obesity results in higher PD-1-mediated T-cell suppression but greater T-cell effector functions following blockade.
Canter, R. J., Aguilar, E., Wang, Z., Le, C., Khuat, L., Dunai, C., . . . Murphy, W. J. (2018). Obesity results in higher PD-1-mediated T-cell suppression but greater T-cell effector functions following blockade.. Journal of Clinical Oncology, 36(5_suppl), 65. doi:10.1200/jco.2018.36.5_suppl.65
2017
Licensing delineates helper and effector NK cell subsets during viral infection
Zamora, A. E., Aguilar, E. G., Sungur, C. M., Khuat, L. T., Dunai, C., Lochhead, G. R., . . . Murphy, W. J. (2017). Licensing delineates helper and effector NK cell subsets during viral infection. JCI INSIGHT, 2(10). doi:10.1172/jci.insight.87032
Obesity predisposes to rapid gastrointestinal graft-versus-host disease lethality after allogeneic hematopoietic stem cell transplantation in mice
Khuat, L. T., Pai, C. -C. S., Chen, M., Aguilar, E. G., Dunai, C., Le, C. T., . . . Murphy, W. J. (2017). Obesity predisposes to rapid gastrointestinal graft-versus-host disease lethality after allogeneic hematopoietic stem cell transplantation in mice. The Journal of Immunology, 198(Supplement_1), 82.17. doi:10.4049/jimmunol.198.supp.82.17
The immune environment dictates the dominance of licensed versus unlicensed natural killer cell subsets during viral infection
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