Research
Research Interest 1
Human Protein-protein interaction networks
Research grants
Wellcome Trust Four Year Cellular and Molecular Physiology PhD Programme 2018
WELLCOME TRUST (UK)
October 2018 - March 2023
Wellcome Trust Four-Year PhD Studentship with the Cellular and Molecular Physiology PhD Programme
WELLCOME TRUST (UK)
October 2015 - September 2019
The North West Cancer Bioinformatics Fellowship
NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)
October 2015 - September 2018
Four year PhD Programme (2007)
WELLCOME TRUST (UK)
October 2007 - September 2011
Biochemical characterisation of distinct kinetochore states by purification of intact kinetochore-centromere complexes with attached microtubule plus-ends
ROYAL SOCIETY (CHARITABLE)
November 2010 - October 2011
Investigating the potential of Nrf2 induction in airway epithelial cells as a treatment for RSV bronchiolitis
BRITISH SOCIETY FOR ANTIMICROBIAL CHEMOTHERAPY (UK)
August 2013 - December 2014
Developing a collaborative resource for ChIP based analyses of cancer related transcriptional networks
CANCER RESEARCH UK (UK)
April 2012 - March 2013
Four year PhD Programme (2008)
WELLCOME TRUST (UK)
October 2008 - December 2012
Wellcome Trust Four-Year PhD Studentship with the Cellular and Molecular Physiology Programme
WELLCOME TRUST (UK)
October 2011 - March 2016
Comparative network profiling of normal and cancer-derived gastric myofibroblasts.
NORTH WEST CANCER RESEARCH FUND
June 2009 - May 2010
Securing and enhancing Liverpool Biomedical EM cryo-preparation facilities
WELLCOME TRUST (UK)
July 2007 - June 2010
Dynamics and function of the NF-kappaB signalling system
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
May 2008 - July 2014
Bench fees for Hanan M Garalla
LIBYAN EMBASSY IN LONDON🚩
July 2013 - June 2016
CR-UK Cancer Research Centre - Non Clinical Training Account 2010-2014
CANCER RESEARCH UK (UK)
November 2011 - October 2015
Wellcome trust four-year PhD studentship with the cellular and molecular physiology PhD programme
WELLCOME TRUST (UK)
October 2012 - September 2016
Four year PhD programme for Mr Woodsmith.
WELLCOME TRUST (UK)
October 2006 - September 2010
Exo-Net.
MEDICAL RESEARCH COUNCIL
June 2006 - May 2009
Liverpool 3View: a national hub for 3D-EM bioscience research
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
January 2014 - December 2014
Research collaborations
Prof. Munir Pirmohamed
We are in the process of preparing an application for a Wellcome Trust Strategic award. This will focus on Pharmacogenomics of Infants. I will provide supporting expertise in Systems Biology/Network Biology
Prof. Mike White
I am a co-applicant on Mike's large BBSRC SABR Systems Biology grant. In addition, we also secured funding for 4x 4-year PhD studentshipd form the BBSRC. Finally we are currently developing plans for using microscopic methods to investigate conditional protein-protein interactions in live human cells.
Prof. Rob Baynon
We are both involved in the BBSRC funded SBR Systems Biology project. In addition we are currently discussing plans for a possible co-appliaction to study global protein degradation/ ubiquitination profilesin eukaryotic cells. These plans are still in an early phase as they must follow publication of our manuscript on the Human E2/E3-RING interaction network.
Prof. Lu-Yun Lian
We are working together to generate NMR/structural information relating to novel human E2-E3/RING and E2/DUB protein complexes. This work will also form the foundation for a future joint grant application in this field which will be led by myself but with 50% split on credit. It is my intention that together we can establish Liverpool as a recognised centre for the analysis of hirachical/combinatorial protein complexes.
Dr David Kommander
Laboratory of Molecular Biology, MRC, Cambridge
We haveve collaborated for about three years on different projects but most recently David performed functional ubiquitination assays in oreder to asses the accuracy of our experimental predictions. This was a very sucessful collaboration which will result in a joint publication. Additional experiments are been discussed to support a future grant application.
Dr B. Lehner
Centre for Genomic Regulation, Barcelona/EMBL outstation
using worm genetic networks to investigate human protein-protein interaction networks
L. Serano/ C. Kiel
Centre for Genomic Regulation, Barcelona/EMBL outstation
Investigating the molecular basis of partner preferences within the Humanb ubiquitome.
Dr Evan Reid
The University of Cambridge
Dr Reid initially came to work as a visiting researcher in my group when I was working at the MRC Rosalind Franklin Centre for Genomics Research in Hinxton Cambridge. During this period we performed several protein interaction studies to identify novel proteins that interact with proteins encoded by genes involved in hereditary Spastic Paraplegia. To date this work produced three publications which provide novel insights into possible mechanisms of neuronal degeneration. In addition this work also led to the identification of novel components of the human endocytic pathway. We are both keen to continue this successful collaboration and as such we are performing several ongoing research projects and applying for joint funding to investigate a new candidate genes which are also linked to spastic paraplegia and neuronal degeneration.
Dr Sean Munro
The University of Cambridge
Analysis of interaction partners for a series of human Arl proteins
Dr Paul Luzio
The University of Cambridge
Investigation of interaction partners for proteins involved in endocytosis in human cells
Dr Paul Lehner
The University of Cambridge
An analysis of interactions between viral ubiquitin ligases and human Ubiquitin cinjugating enzymes (E2s)