Research outputs
2026
Methodological Pitfalls in Endometriosis Biospecimen Research: Lessons From MAP4K4 Expression Studies
Badran, D., Clarke, H., Salvini, S., Drury, J., Tempest, N., Maclean, A., . . . Hapangama, D. K. (2026). Methodological Pitfalls in Endometriosis Biospecimen Research: Lessons From MAP4K4 Expression Studies. FASEB BIOADVANCES, 8(9), 11 pages. doi:10.1096/fba.2026-00156
Complex in vitro 3D modelling of endometriosis and endometrial disorders
Hill, C., Rahmana, D., Wilm, B., Zagnoni, M., Sandison, M., & Hapangama, D. (2026). Complex in vitro 3D modelling of endometriosis and endometrial disorders. HUMAN REPRODUCTION, 41, 2 pages. doi:10.1093/humrep/deag083.103
Menstrual cycle-dependent spatial-omics heterogeneity in uterine fibroids and adjacent myometrium
Salvini, L., Hill, C. J., Harris, J., Robinson, S., Davison, A., Johnson, E., . . . Hapangama, D. K. (2026). Menstrual cycle-dependent spatial-omics heterogeneity in uterine fibroids and adjacent myometrium. In HUMAN REPRODUCTION Vol. 41 (pp. 2 pages). doi:10.1093/humrep/deag083.082
Spatial transcriptomic insights between eutopic endometrium, ectopic endometriosis and adenomyosis lesions
Jones, K., Hill, C., Johnson, E., Caamano Gutierrez, E., Arshad, I., Ahmed, S., & Hapangama, D. (2026). Spatial transcriptomic insights between eutopic endometrium, ectopic endometriosis and adenomyosis lesions. HUMAN REPRODUCTION, 41, 1 page. doi:10.1093/humrep/deag083.326
Spatial transcriptomics uncovers the hybrid molecular identity, ciliated phenotype, and immune signature of adenomyosis lesions
Maclean, A., Johnson, E., Rushworth, C., Hill, C. J., Gutierrez, E. C., & Hapangama, D. K. (2026). Spatial transcriptomics uncovers the hybrid molecular identity, ciliated phenotype, and immune signature of adenomyosis lesions. SCIENCE ADVANCES, 12(26), 16 pages. doi:10.1126/sciadv.aea6379
Compound design of a patient-derived 3D cell culture system modelling early peritoneal endometriosis
Rahmana, M. D. R., Hill, C. J., Wilm, B., & Hapangama, D. K. (2026). Compound design of a patient-derived 3D cell culture system modelling early peritoneal endometriosis. DISEASE MODELS & MECHANISMS, 19(6), 12 pages. doi:10.1242/dmm.052436
High prevalence of irritable bowel syndrome in women with chronic pelvic pain and discerning features relevant to deep endometriosis
Powell, S. G., Wyatt, J. N. R., Arshad, I., Ahmed, S., Hill, C. J., Probert, C., & Hapanagama, D. K. (2026). High prevalence of irritable bowel syndrome in women with chronic pelvic pain and discerning features relevant to deep endometriosis. Journal of Endometriosis and Uterine Disorders, 14. doi:10.1016/j.jeud.2025.100148
Hydrosalpinx perturbs the tubal and endometrial immune environment
Aljassim, F., Rigby, C. H., Drury, J. A., Alnafakh, R., Rushworth, C., Maclean, A., . . . Hill, C. J. (2026). Hydrosalpinx perturbs the tubal and endometrial immune environment. REPRODUCTION AND FERTILITY, 7(2), 8 pages. doi:10.1530/RAF-25-0204
EPICON: A Patient-Derived Multicellular 3D Model of the Endometrial-Peritoneal Interface Construct to Study Early Peritoneal Endometriosis
Rahmana, M., Hill, C., Wilm, B., & Hapangama, D. (2026). EPICON: A Patient-Derived Multicellular 3D Model of the Endometrial-Peritoneal Interface Construct to Study Early Peritoneal Endometriosis. In REPRODUCTIVE SCIENCES Vol. 33 (pp. 1 page). Retrieved from https://www.webofscience.com/
Handbrake on Hysterectomy: Multi-Omics Mapping of Uterine Fibroids to Enable Personalised Fertility-Preserving Therapeutics
Salvini, L., Paterson, K., Hill, C., Sandison, M., Zagnoni, M., Harris, J., . . . Hapangama, D. (2026). Handbrake on Hysterectomy: Multi-Omics Mapping of Uterine Fibroids to Enable Personalised Fertility-Preserving Therapeutics. In REPRODUCTIVE SCIENCES Vol. 33 (pp. 1 page). Retrieved from https://www.webofscience.com/
How distinct are endometriosis and adenomyosis from the eutopic endometrium? Insights from spatial transcriptomics
Jones, K., Hill, C., Johnson, E., Caamano-Gutierrez, E., Arshad, I., Ahmed, S., & Hapangama, D. (2026). How distinct are endometriosis and adenomyosis from the eutopic endometrium? Insights from spatial transcriptomics. In REPRODUCTIVE SCIENCES Vol. 33 (pp. 1 page). Retrieved from https://www.webofscience.com/
Association between Uterine Fibroids and Postpartum Haemorrhage after Term Vaginal Birth: A Single Site Audit of 511 Patients  
2025
Patient preferences for non-invasive diagnostic biospecimens among women with chronic pelvic pain: A cross-sectional survey
Wyatt, J., Powell, S. G., Arshad, I., Hill, C. J., Maclean, A., Probert, C., . . . Hapangama, D. K. (2025). Patient preferences for non-invasive diagnostic biospecimens among women with chronic pelvic pain: A cross-sectional survey. Journal of Endometriosis and Uterine Disorders, 11. doi:10.1016/j.jeud.2025.100121
Liquid chromatography-mass spectrometry profiling of the urine metabolome in adverse early pregnancy outcomes
Hill, C., Davison, A., Norman, B., Phelan, M., Tempest, N., & Hapangama, D. (2025). Liquid chromatography-mass spectrometry profiling of the urine metabolome in adverse early pregnancy outcomes. HUMAN REPRODUCTION, 40, 1 page. doi:10.1093/humrep/deaf097.080
P-351 Optimisation of an in vitro patient-derived multicellular model to recapitulate superficial endometriotic lesion formation
Rahmana, M. D. R., Hill, C. J., Wilm, B., & Hapangama, D. K. (2025). P-351 Optimisation of an in vitro patient-derived multicellular model to recapitulate superficial endometriotic lesion formation. Human Reproduction, 40(Supplement_1), deaf097.658. doi:10.1093/humrep/deaf097.658
Transcriptional Profiling of SSEA-1<SUP>+</SUP> Endometrial Epithelial Progenitor Cells Highlights Their Role in Endometrial Regeneration, Remodeling, and Homeostasis
Al-Lamee, H., Soul, J., Green, D., Drury, J., Hill, C. J., Vasieva, O., . . . Hapangama, D. K. (2025). Transcriptional Profiling of SSEA-1<SUP>+</SUP> Endometrial Epithelial Progenitor Cells Highlights Their Role in Endometrial Regeneration, Remodeling, and Homeostasis. FASEB JOURNAL, 39(9), 20 pages. doi:10.1096/fj.202402861R
Cell type and region- specific transcriptional changes in the endometrium of women with RIF identify potential treatment targets
Tempest, N., Soul, J., Hill, C. J., Gutierrez, E. C., & Hapangama, D. K. (2025). Cell type and region- specific transcriptional changes in the endometrium of women with RIF identify potential treatment targets. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 122(11), 9 pages. doi:10.1073/pnas.2421254122
Compound design of a patient-derived 3D cell culture system modelling early peritoneal endometriosis
Hormonal Control of the Fallopian Tube
Dutton, P. J., Maclean, A. J., Aljassim, F., Badran, D., McKinley, A., Bunni, E., . . . Hapangama, D. K. (2025). Hormonal Control of the Fallopian Tube. In Fallopian Tube Physiology and Clinical Aspects (pp. 106-131). doi:10.1142/9789811263965_0006
2024
Functional, patient-derived 3D tri-culture models of the uterine wall in a microfluidic array
Busch, C., Hill, C. J., Paterson, K., Mellin, R., Zagnoni, M., Hapangama, D. K., & Sandison, M. E. (2024). Functional, patient-derived 3D tri-culture models of the uterine wall in a microfluidic array. HUMAN REPRODUCTION, 39(11), 15 pages. doi:10.1093/humrep/deae214
P-312 Transcriptional profiling of SSEA-1+ endometrial epithelial cells highlights their role in endometrial regeneration, remodelling and homeostasis
Al-Lamee, H., Soul, J., Green, D., Drury, J., Hill, C., Valentijn, A., . . . Hapangama, D. (2024). P-312 Transcriptional profiling of SSEA-1+ endometrial epithelial cells highlights their role in endometrial regeneration, remodelling and homeostasis. Human Reproduction, 39(Supplement_1), deae108.677. doi:10.1093/humrep/deae108.677
P-321 Uterine fibroids secrete vasodilatory factors that induce their response via the opioid pathway
Hill, C., Yasin, S., Whitmore, J., Tempest, N., Fakhreldin, M., Oktaba, M., . . . Hapangama, D. (2024). P-321 Uterine fibroids secrete vasodilatory factors that induce their response via the opioid pathway. Human Reproduction, 39(Supplement_1), deae108.686. doi:10.1093/humrep/deae108.686
Diagnostic utility of clinicodemographic, biochemical and metabolite variables to identify viable pregnancies in a symptomatic cohort during early gestation.
Hill, C. J., Phelan, M. M., Dutton, P. J., Busuulwa, P., Maclean, A., Davison, A. S., . . . Hapangama, D. K. (2024). Diagnostic utility of clinicodemographic, biochemical and metabolite variables to identify viable pregnancies in a symptomatic cohort during early gestation.. Scientific reports, 14(1), 11172. doi:10.1038/s41598-024-61690-3
2023
Exploring the presence of markers of decidualization in the fallopian tubes: a systematic review
Aljassim, F., Georgopoulou, N., Rigby, C. H., Powell, S. G., Wyatt, J. N. R., Hapangama, D. K., & Hill, C. J. (2023). Exploring the presence of markers of decidualization in the fallopian tubes: a systematic review. BIOLOGY OF REPRODUCTION, 109(2), 125-136. doi:10.1093/biolre/ioad062
The role of iron in the pathogenesis of endometriosis: a systematic review
Wyatt, J., Fernando, S. M., Powell, S. G., Hill, C. J., Arshad, I., Probert, C., . . . Hapangama, D. K. (2023). The role of iron in the pathogenesis of endometriosis: a systematic review. HUMAN REPRODUCTION OPEN, 2023(3), 19 pages. doi:10.1093/hropen/hoad033
Organ-on-a-Chip Models of the Uterine Wall
Hill, C. J., Busch, C., Maclean, A., Hapangama, D. K., Zagnoni, M., & Sandison, M. E. (2023). Organ-on-a-Chip Models of the Uterine Wall. In REPRODUCTIVE SCIENCES Vol. 30 (pp. 199A). Retrieved from https://www.webofscience.com/
2022
The immune cell profile of human fallopian tubes in health and benign pathology: a systematic review
Rigby, C. H., Aljassim, F., Powell, S. G., Wyatt, J. N. R., Hill, C. J., & Hapangama, D. K. (2022). The immune cell profile of human fallopian tubes in health and benign pathology: a systematic review. JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 152, 13 pages. doi:10.1016/j.jri.2022.103646
O-258 Nuclear magnetic resonance profiling of the vaginal metabolome in adverse early pregnancy outcomes
Hill, C., Phelan, M., Dutton, P., Busuulwa, P., Horne, A., Gemzell-Danielsson, K., . . . Hapangama, D. (2022). O-258 Nuclear magnetic resonance profiling of the vaginal metabolome in adverse early pregnancy outcomes. Human Reproduction, 37(Supplement_1), deac106.040. doi:10.1093/humrep/deac106.040
P-330 The immune cell population of the human fallopian tubes in health and benign pathology: a systematic review
Aljassim, F., Rigby, C., Powell, S., Wyatt, J., Hill, C., & Hapangama, D. (2022). P-330 The immune cell population of the human fallopian tubes in health and benign pathology: a systematic review. Human Reproduction, 37(Supplement_1), deac107.314. doi:10.1093/humrep/deac107.314
P-375 Optimising vaginal biospecimen collection
Turner, F., Drury, J., Goodfellow, L., Hill, C., Baxter, H., Milanova, V., . . . Tempest, N. (2022). P-375 Optimising vaginal biospecimen collection. Human Reproduction, 37(Supplement_1), deac107.353. doi:10.1093/humrep/deac107.353
P-433 Comparative analysis of serum obtained in early pregnancy using Fourier transform-infrared spectroscopy to predict tubal ectopic pregnancy and miscarriage
Lima, C., Dutton, P., Hill, C., Busuulwa, P., Goodacre, R., & Hapangama, D. (2022). P-433 Comparative analysis of serum obtained in early pregnancy using Fourier transform-infrared spectroscopy to predict tubal ectopic pregnancy and miscarriage. Human Reproduction, 37(Supplement_1), deac107.408. doi:10.1093/humrep/deac107.408
Characterisation of novel in-vitro 3D cell-culture model of adenomyosis
Maclean, A., Hill, C., & Hapangama, D. (2022). Characterisation of novel in-vitro 3D cell-culture model of adenomyosis. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 129 (pp. 9). Retrieved from https://www.webofscience.com/
Immune profile of the fallopian tubes in benign pathologies: a systematic review
Rigby, C., Aljassim, F., Powell, S., Wyattl, J., Hill, C., & Hapangama, D. (2022). Immune profile of the fallopian tubes in benign pathologies: a systematic review. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 129 (pp. 11). Retrieved from https://www.webofscience.com/
Predicting tubal ectopic pregnancy and miscarriage in serum using Fourier transform-infrared spectroscopy
Dutton, P., Lima, C., Hill, C., Busuulwa, P., Goodacre, R., & Hapangama, D. (2022). Predicting tubal ectopic pregnancy and miscarriage in serum using Fourier transform-infrared spectroscopy. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 129 (pp. 19-20). Retrieved from https://www.webofscience.com/
Transcriptional profile of SSEA-1 endometrial epithelial cells; the proposed progenitor cell population
Al-Lamee, H., Tempest, N., Green, D., Hill, C., Drury, J., Vasieva, O., . . . Hapangama, D. (2022). Transcriptional profile of SSEA-1 endometrial epithelial cells; the proposed progenitor cell population. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 129 (pp. 62). Retrieved from https://www.webofscience.com/
The Role of Endometrial Stem/Progenitor Cells in Recurrent Reproductive Failure
Al-Lamee, H., Hill, C. J., Turner, F., Phan, T., Drakeley, A. J., Hapangama, D. K., & Tempest, N. (2022). The Role of Endometrial Stem/Progenitor Cells in Recurrent Reproductive Failure. JOURNAL OF PERSONALIZED MEDICINE, 12(5), 17 pages. doi:10.3390/jpm12050775
Altered endometrial oestrogen-responsiveness and recurrent reproductive failure
Al-Lamee, H., Ellison, A., Drury, J., Hill, C. J., Drakeley, A. J., Hapangama, D. K., & Tempest, N. (2022). Altered endometrial oestrogen-responsiveness and recurrent reproductive failure. REPRODUCTION AND FERTILITY, 3(1), 30-38. doi:10.1530/RAF-21-0093
Bipartite Collagen-Agarose Scaffolds to Model Eutopic Embryo Implantation
Hill, C. J., Aljassim, F., Phelan, M. M., Tempest, N., & Hapangama, D. K. (2022). Bipartite Collagen-Agarose Scaffolds to Model Eutopic Embryo Implantation. In REPRODUCTIVE SCIENCES Vol. 29 (pp. 185). Retrieved from https://www.webofscience.com/
Characterisation of Novel <i>In Vitro</i> 3D Cell Culture Model of Adenomyosis
Maclean, A., Hill, C. J., & Hapangama, D. K. (2022). Characterisation of Novel <i>In Vitro</i> 3D Cell Culture Model of Adenomyosis. In REPRODUCTIVE SCIENCES Vol. 29 (pp. 69). Retrieved from https://www.webofscience.com/
Identification of Genes Associated with Endometrial Decidualisation in the Presence or Absence of an Embryo
Phan, T., Tempest, N., Hill, C. J., Choi, F., Al-Lamee, H., Drakeley, A. J., & Hapangama, D. K. (2022). Identification of Genes Associated with Endometrial Decidualisation in the Presence or Absence of an Embryo. In REPRODUCTIVE SCIENCES Vol. 29 (pp. 185-186). Retrieved from https://www.webofscience.com/
Identification of Key Genes, Regulatory Factors and Potential Drugs for Recurrent Reproductive Failure: An In Silico Analysis.
Phan, T., Hill, C. J., Choi, F., Al-Lamee, H., Drakeley, A. J., Hapangama, D. K., & Tempest, N. (2022). Identification of Key Genes, Regulatory Factors and Potential Drugs for Recurrent Reproductive Failure: An In Silico Analysis.. In REPRODUCTIVE SCIENCES Vol. 29 (pp. 270). Retrieved from https://www.webofscience.com/
Novel microarchitecture of human endometrial glands: implications in endometrial regeneration and pathologies
Tempest, N., Hill, C. J., Maclean, A., Marston, K., Powell, S. G., Al-Lamee, H., & Hapangama, D. K. (2022). Novel microarchitecture of human endometrial glands: implications in endometrial regeneration and pathologies. HUMAN REPRODUCTION UPDATE, 28(2), 153-171. doi:10.1093/humupd/dmab039
2021
Symptomatology and Serum Nuclear Magnetic Resonance Metabolomics; Do They Predict Endometriosis in Fertile Women Undergoing Laparoscopic Sterilisation? A Prospective Cross-sectional Study
Tempest, N., Hill, C. J., Whelan, A., De Silva, A., Drakeley, A. J., Phelan, M. M., & Hapangama, D. K. (2021). Symptomatology and Serum Nuclear Magnetic Resonance Metabolomics; Do They Predict Endometriosis in Fertile Women Undergoing Laparoscopic Sterilisation? A Prospective Cross-sectional Study. REPRODUCTIVE SCIENCES, 28(12), 3480-3490. doi:10.1007/s43032-021-00725-w
O-234 Using serum metabolomics to identify biomarkers of viable early, intrauterine pregnancy: an untargeted 1H NMR-based approach
Hill, C., Phelan, M., Horne, A., Gemzell-Danielsson, K., Tempest, N., & Hapangama, D. (2021). O-234 Using serum metabolomics to identify biomarkers of viable early, intrauterine pregnancy: an untargeted 1H NMR-based approach. Human Reproduction, 36(Supplement_1), deab128.058. doi:10.1093/humrep/deab128.058
Using Serum Metabolomics to Identify Biomarkers of Viable Early, Intrauterine Pregnancy: An Untargeted <SUP>1</SUP>H NMR-Based Approach.
Hill, C. J., Phelan, M., Horne, A., Gemzell-Danielsson, K., Tempest, N., & Hapangama, D. (2021). Using Serum Metabolomics to Identify Biomarkers of Viable Early, Intrauterine Pregnancy: An Untargeted <SUP>1</SUP>H NMR-Based Approach.. In REPRODUCTIVE SCIENCES Vol. 28 (pp. 297A). Retrieved from https://www.webofscience.com/
Anterior Gradient Protein 3 and S100 Calcium-Binding Protein P Levels in Different Endometrial Epithelial Compartments May Play an Important Role in Recurrent Pregnancy Failure
Tempest, N., Batchelor, E., Hill, C. J., Al-Lamee, H., Drury, J., Drakeley, A. J., & Hapangama, D. K. (2021). Anterior Gradient Protein 3 and S100 Calcium-Binding Protein P Levels in Different Endometrial Epithelial Compartments May Play an Important Role in Recurrent Pregnancy Failure. International Journal of Molecular Sciences, 22(8), 3835. doi:10.3390/ijms22083835
2020
Investigating the Role of Telomere and Telomerase Associated Genes and Proteins in Endometrial Cancer
Bradfield, A., Button, L., Drury, J., Green, D. C., Hill, C. J., & Hapangama, D. K. (2020). Investigating the Role of Telomere and Telomerase Associated Genes and Proteins in Endometrial Cancer. METHODS AND PROTOCOLS, 3(3). doi:10.3390/mps3030063
Histological3Dreconstruction and<i>in vivo</i>lineage tracing of the human endometrium
Tempest, N., Jansen, M., Baker, A. -M., Hill, C. J., Hale, M., Magee, D., . . . Hapangama, D. K. (2020). Histological3Dreconstruction and<i>in vivo</i>lineage tracing of the human endometrium. JOURNAL OF PATHOLOGY, 251(4), 440-451. doi:10.1002/path.5478
Endometriosis and the Fallopian Tubes: Theories of Origin and Clinical Implications
Hill, C. J., Fakhreldin, M., Maclean, A., Dobson, L., Nancarrow, L., Bradfield, A., . . . Hapangama, D. K. (2020). Endometriosis and the Fallopian Tubes: Theories of Origin and Clinical Implications. JOURNAL OF CLINICAL MEDICINE, 9(6), 21 pages. doi:10.3390/jcm9061905
Assessing Human Embryonic Stem Cell-Derived Dopaminergic Neuron Progenitor Transplants Using Non-invasive Imaging Techniques
Hill, C. (2020). Assessing Human Embryonic Stem Cell-Derived Dopaminergic Neuron Progenitor Transplants Using Non-invasive Imaging Techniques. Molecular Imaging and Biology. doi:10.1007/s11307-020-01499-4
Multicenter External Validation of the Liverpool Uveal Melanoma Prognosticator Online: An OOG Collaborative Study
Rola, A. C., Taktak, A., Eleuteri, A., Kalirai, H., Heimann, H., Hussain, R., . . . Coupland, S. E. (2020). Multicenter External Validation of the Liverpool Uveal Melanoma Prognosticator Online: An OOG Collaborative Study. CANCERS, 12(2), 13 pages. doi:10.3390/cancers12020477
2019
The ZT Biopolymer: A Self-Assembling Protein Scaffold for Stem Cell Applications
Nesterenko, Y., Hill, C. J., Fleming, J. R., Murray, P., & Mayans, O. (2019). The ZT Biopolymer: A Self-Assembling Protein Scaffold for Stem Cell Applications. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(17), 15 pages. doi:10.3390/ijms20174299
Self-Assembling Proteins as High-Performance Substrates for Embryonic Stem Cell Self-Renewal
Hill, C. J., Fleming, J. R., Mousavinejad, M., Nicholson, R., Tzokov, S. B., Bullough, P. A., . . . Murray, P. (2019). Self-Assembling Proteins as High-Performance Substrates for Embryonic Stem Cell Self-Renewal. Advanced Materials, 31(17). doi:10.1002/adma.201807521
2017
Regulating stem cell behaviour using bioengineered culture substrates
Hill, C. J. (2017, March 1). Regulating stem cell behaviour using bioengineered culture substrates.