Publications
2023
Study design for development of novel safety biomarkers of drug-induced liver injury by the translational safety biomarker pipeline (TransBioLine) consortium: a study protocol for a nested case-control study.
Grove, J. I., Stephens, C., Lucena, M. I., Andrade, R. J., Weber, S., Gerbes, A., . . . TransBioLine consortium. (2023). Study design for development of novel safety biomarkers of drug-induced liver injury by the translational safety biomarker pipeline (TransBioLine) consortium: a study protocol for a nested case-control study.. Diagnostic and prognostic research, 7(1), 18. doi:10.1186/s41512-023-00155-z
Analysis of serum microRNA-122 in a randomized controlled trial of N-acetylcysteine for treatment of antituberculosis drug-induced liver injury
Moosa, M. S., Russomanno, G., Dorfman, J. R., Gunter, H., Patel, C., Costello, E., . . . Cohen, K. (2023). Analysis of serum microRNA-122 in a randomized controlled trial of N-acetylcysteine for treatment of antituberculosis drug-induced liver injury. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. doi:10.1111/bcp.15661
In Vivo Tumorigenicity of the 20q11.21 Amplicon in an Engraftment Model of hPSCs and Differentiated Liver Cells
Pridgeon, C. S., Forootan, S. S., Zhang, F., Harper, N., Palmer, D., Weightmann, R., . . . Goldring, C. E. P. (2023). In Vivo Tumorigenicity of the 20q11.21 Amplicon in an Engraftment Model of hPSCs and Differentiated Liver Cells. JOURNAL OF STEM CELLS & REGENERATIVE MEDICINE, 19(1), P2-P12. doi:10.46582/jsrm.1901002
Genomic profiling of idiopathic peri-hilar cholangiocarcinoma reveals new targets and mutational pathways
Quinn, L. M., Haldenby, S., Antzcak, P., Fowler, A., Bullock, K., Kenny, J., . . . Goldring, C. (n.d.). Genomic profiling of idiopathic peri-hilar cholangiocarcinoma reveals new targets and mutational pathways. Scientific Reports, 13(1). doi:10.1038/s41598-023-33096-0
VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells
Mondru, A. K., Aljasir, M. A., Alrumayh, A., Nithianandarajah, G. N., Ahmed, K., Muller, J., . . . Cross, M. J. (2023). VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells. CELLS, 12(6). doi:10.3390/cells12060967
2022
Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity
Ghallab, A., Hassan, R., Hofmann, U., Friebel, A., Hobloss, Z., Brackhagen, L., . . . Hengstler, J. G. (2022). Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity. JOURNAL OF HEPATOLOGY, 77(1), 71-83. doi:10.1016/j.jhep.2022.01.020
A MicroRNA Next-Generation-Sequencing Discovery Assay (miND) for Genome-Scale Analysis and Absolute Quantitation of Circulating MicroRNA Biomarkers
Khamina, K., Diendorfer, A. B., Skalicky, S., Weigl, M., Pultar, M., Krammer, T. L., . . . Hackl, M. (2022). A MicroRNA Next-Generation-Sequencing Discovery Assay (miND) for Genome-Scale Analysis and Absolute Quantitation of Circulating MicroRNA Biomarkers. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(3). doi:10.3390/ijms23031226
2021
Systems analysis of miRNA biomarkers to inform drug safety
Schofield, A. L., Brown, J. P., Brown, J., Wilczynska, A., Bell, C., Glaab, W. E., . . . Goldring, C. (2021). Systems analysis of miRNA biomarkers to inform drug safety. ARCHIVES OF TOXICOLOGY, 95(11), 3475-3495. doi:10.1007/s00204-021-03150-9
The application of cytokeratin-18 as a biomarker for drug-induced liver injury
Korver, S., Bowen, J., Pearson, K., Gonzalez, R. J., French, N., Park, K., . . . Goldring, C. (2021). The application of cytokeratin-18 as a biomarker for drug-induced liver injury. ARCHIVES OF TOXICOLOGY, 95(11), 3435-3448. doi:10.1007/s00204-021-03121-0
Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration
Chan, B. K. Y., Elmasry, M., Forootan, S. S., Russomanno, G., Bunday, T. M., Zhang, F., . . . Copple, I. M. (2021). Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration. HEPATOLOGY, 74(2), 973-986. doi:10.1002/hep.31859
Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification
Howell, L., Jenkins, R. E., Lynch, S., Duckworth, C., Kevin Park, B., & Goldring, C. (2021). Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification. ARCHIVES OF TOXICOLOGY, 95(7), 2413-2430. doi:10.1007/s00204-021-03075-3
Gene signatures reduce the stress of preclinical drug hepatotoxicity screening.
Copple, I. M., Park, B. K., & Goldring, C. E. (2021). Gene signatures reduce the stress of preclinical drug hepatotoxicity screening.. Hepatology (Baltimore, Md.). doi:10.1002/hep.31736
2020
Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells
Matthews, O., Morrison, E. E., Tranter, J. D., Lewis, P. S., Toor, I. S., Srivastava, A., . . . Dear, J. W. (2020). Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells. EBIOMEDICINE, 62. doi:10.1016/j.ebiom.2020.103092
Critical considerations for targeting colorectal liver metastases with nanotechnology
Arshad, U., Sutton, P. A., Ashford, M. B., Treacher, K. E., Liptrott, N. J., Rannard, S. P., . . . Owen, A. (2020). Critical considerations for targeting colorectal liver metastases with nanotechnology. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 12(2). doi:10.1002/wnan.1588
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
Weaver, R. J., Blomme, E. A., Chadwick, A. E., Copple, I. M., Gerets, H. H. J., Goldring, C. E., . . . Park, B. K. (2020). Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models. NATURE REVIEWS DRUG DISCOVERY, 19(2), 131-148. doi:10.1038/s41573-019-0048-x
2019
Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research
Evans, J. P., Winiarski, B. K., Sutton, P. A., Ressel, L., Duckworth, C. A., Pritchard, D. M., . . . Kitteringham, N. R. (2019). Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research. LABORATORY ANIMALS, 53(6), 598-609. doi:10.1177/0023677219826165
Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system.
Ogese, M. O., Jenkins, R. E., Adair, K., Tailor, A., Meng, X., Faulkner, L. L., . . . Betts, C. (2019). Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system.. Hepatology, 70(5), 1732-1749. doi:10.1002/hep.30701
Stem cell models as an <i>in vitro</i> model for predictive toxicology
Lynch, S., Pridgeon, C. S., Duckworth, C. A., Sharma, P., Park, B. K., & Goldring, C. E. P. (2019). Stem cell models as an <i>in vitro</i> model for predictive toxicology. BIOCHEMICAL JOURNAL, 476, 1149-1158. doi:10.1042/BCJ20170780
Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury
Copple, I. M., den Hollander, W., Callegaro, G., Mutter, F. E., Maggs, J. L., Schofield, A. L., . . . Park, B. K. (2019). Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury. Archives of Toxicology, 93, 385-399. doi:10.1007/s00204-018-2354-1
Application of porcine gastrointestinal organoid units as a potential in vitro tool for drug discovery and development
Olayanju, A., Jones, L., Greco, K., Goldring, C. E., & Ansari, T. (2019). Application of porcine gastrointestinal organoid units as a potential in vitro tool for drug discovery and development. JOURNAL OF APPLIED TOXICOLOGY, 39(1), 4-15. doi:10.1002/jat.3641
2018
Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds
Oppelt, A., Kaschek, D., Huppelschoten, S., Sison-Young, R., Zhang, F., Buck-Wiese, M., . . . Klingmueuler, U. (2018). Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds. NPJ SYSTEMS BIOLOGY AND APPLICATIONS, 4. doi:10.1038/s41540-018-0058-z
Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop
Stacey, G., Andrews, P. W., Asante, C., Barbaric, I., Barry, J., Bisset, L., . . . Williams, D. (2018). Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop. REGENERATIVE MEDICINE, 13(8), 935-944. doi:10.2217/rme-2018-0120
The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer
Evans, J. P., Winiarski, B. K., Sutton, P. A., Jones, R. P., Ressel, L., Duckworth, C. A., . . . Kitteringham, N. R. (2018). The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer. Oncotarget, 9(43), 27104-27116. doi:10.18632/oncotarget.25497
Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response
Bowden, D. L., Sutton, P. A., Wall, M. A., Jithesh, P. V., Jenkins, R. E., Palmer, D. H., . . . Vimalachandran, D. (2018). Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response. JOURNAL OF PROTEOMICS, 179, 53-60. doi:10.1016/j.jprot.2018.02.030
NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis
Lister, A., Bourgeois, S., Silva, P. H. I., Rubio-Aliaga, I., Marbet, P., Walsh, J., . . . Odermatt, A. (2018). NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis. SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-018-24000-2
Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study
Bell, C. C., Dankers, A. C. A., Lauschke, V. M., Sison-Young, R., Jenkins, R., Rowe, C., . . . Ingelman-Sundberg, M. (2018). Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study. TOXICOLOGICAL SCIENCES, 162(2), 655-666. doi:10.1093/toxsci/kfx289
Innovative Organotypic In Vitro Models for Safety Assessment: Aligning with regulatory requirements and understanding models of the heart, skin and liver as paradigms
Park, B. K., & Goldring, C. (2018). Innovative Organotypic In Vitro Models for Safety Assessment: Aligning with regulatory requirements and understanding models of the heart, skin and liver as paradigms. Archives of Toxicology, 92(2), 557-569. doi:10.1007/s00204-018-2152-9
Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins
Rowe, C., Shaeri, M., Large, E., Cornforth, T., Robinson, A., Kostrzewski, T., . . . Hughes, D. (2018). Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins. TOXICOLOGY IN VITRO, 46, 29-38. doi:10.1016/j.tiv.2017.09.012
Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: A multi-center study
Bell, C., Dankers, A., Lauschke, V., Sison-Young, R., Jenkins, R., Rowe, C., . . . Ingelman-Sundberg, M. (2018). Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: A multi-center study. Toxicological Sciences. doi:10.1093/toxsci/kfx289
MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury
Howell, L. S., Ireland, L., Park, B. K., & Goldring, C. E. (2018). MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 18(1), 47-54. doi:10.1080/14737159.2018.1415145
Exome sequencing of synchronously resected primary colorectal tumours and colorectal liver metastases to inform oncosurgical management
Sutton, P. A., Jithesh, P. V., Jones, R. P., Evans, J. P., Vimalachandran, D., Malik, H. Z., . . . Kitteringham, N. R. (2018). Exome sequencing of synchronously resected primary colorectal tumours and colorectal liver metastases to inform oncosurgical management. EJSO - European Journal of Surgical Oncology, 44(1), 115-121. doi:10.1016/j.ejso.2017.10.211
Leading-Edge Approaches for In Vitro Hepatotoxicity Evaluation
LeCluyse, E. L., Norona, L. M., Akingbasote, J. A., Howell, L. S., Woodhead, J. L., Cross, M. J., . . . Goldring, C. E. (2018). Leading-Edge Approaches for In Vitro Hepatotoxicity Evaluation. In Comprehensive Toxicology (pp. 651-712). Elsevier. doi:10.1016/b978-0-12-801238-3.64267-8
Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testing
Wong, M. W., Pridgeon, C. S., Schlott, C., Park, B. K., & Goldring, C. E. P. (2018). Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testing. In DRUG-INDUCED LIVER TOXICITY (pp. 199-212). doi:10.1007/978-1-4939-7677-5_10
2017
Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies
Scarfe, L., Brillant, N., Kumar, J. D., Ali, N., Alrumayh, A., Amali, M., . . . Park, B. K. (2017). Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies. NPJ REGENERATIVE MEDICINE, 2. doi:10.1038/s41536-017-0029-9
Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo
Brillant, N., Elmasry, M., Burton, N. C., Rodriguez, J. M., Sharkey, J. W., Fenwick, S., . . . Antoine, D. J. (2017). Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo. TOXICOLOGY AND APPLIED PHARMACOLOGY, 332, 64-74. doi:10.1016/j.taap.2017.07.019
Donor-Dependent and Other Nondefined Factors have Greater Influence on the Hepatic Phenotype than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells (vol 6, 1751, 2017)
Heslop, J. A., Kia, R., Pridgeon, C. S., Sison-Young, R. L., Liloglou, T., Elmasry, M., . . . Park, B. K. (2017). Donor-Dependent and Other Nondefined Factors have Greater Influence on the Hepatic Phenotype than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells (vol 6, 1751, 2017). STEM CELLS TRANSLATIONAL MEDICINE, 6(8). Retrieved from https://www.webofscience.com/
A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat
Thulin, P., Hornby, R. J., Auli, M., Nordahl, G., Antoine, D. J., Lewis, P. S., . . . Schuppe-Koistinen, I. (2017). A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat. BIOMARKERS, 22(5), 461-469. doi:10.1080/1354750X.2016.1269131
Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development
Goldring, C., Weaver, R., Kramer, B., Klingmueller, U., Oppelt, A., Van der Water, B., . . . Park, B. K. (2017). Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development. In COMPREHENSIVE MEDICINAL CHEMISTRY III, VOL 4: EXPERIMENTAL ADME AND TOXICOLOGY (pp. 217-238). doi:10.1016/B978-0-12-409547-2.12384-4
Donor‐Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte‐Like Cells
Heslop, J., Kia, R., Pridgeon, C., Sison-Young, R., Liloglou, T., Elmasry, M., . . . Park, B. K. (2017). Donor‐Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte‐Like Cells. Stem Cells Translational Medicine, 6(5), 1321-1331. doi:10.1002/sctm.16-0029
Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo.
Sharkey, J., Starkey Lewis, P. J., Barrow, M., Alwahsh, S. M., Noble, J., Livingstone, E., . . . Park, B. K. (2017). Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo.. Cytotherapy, 19(4), 555-569. doi:10.1016/j.jcyt.2017.01.003
A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
Sison-Young, R. L., Lauschke, V. M., Johann, E., Alexandre, E., Antherieu, S., Aerts, H., . . . Park, B. K. (2017). A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity. Archives of Toxicology, 91(3), 1385-1400. doi:10.1007/s00204-016-1745-4
Stem Cell-Derived Models to Improve Mechanistic Understanding and Prediction of Human Drug-Induced Liver Injury
Goldring, C., Antoine, D. J., Bonner, F., Crozier, J., Denning, C., Fontana, R. J., . . . Park, B. K. (2017). Stem Cell-Derived Models to Improve Mechanistic Understanding and Prediction of Human Drug-Induced Liver Injury. HEPATOLOGY, 65(2), 710-721. doi:10.1002/hep.28886
Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile
Heslop, J. A., Rowe, C., Walsh, J., Sison-Young, R., Jenkins, R., Kamalian, L., . . . Kevin Park, B. (2017). Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile. Archives of Toxicology, 91(1), 439-452. doi:10.1007/s00204-016-1694-y
2016
Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation
Lauschke, V. M., Vorrink, S. U., Moro, S. M. L., Rezayee, F., Nordling, A., Hendriks, D. F. G., . . . Ingelman-Sundberg, M. (2016). Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation. HEPATOLOGY, 64(5), 1743-1756. doi:10.1002/hep.28780
Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
Bell, C. C., Hendriks, D. F. G., Moro, S. M. L., Ellis, E., Walsh, J., Renblom, A., . . . Ingelman-Sundberg, M. (2016). Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease. Scientific Reports, 6. doi:10.1038/srep25187
Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites
Wong, M. H. L., Bryan, H. K., Copple, I. M., Jenkins, R. E., Chiu, P. H., Bibby, J., . . . Park, B. K. (2016). Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites. JOURNAL OF MEDICINAL CHEMISTRY, 59(6), 2396-2409. doi:10.1021/acs.jmedchem.5b01292
UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis
Abu-Alainin, W., Gana, T., Liloglou, L., Olayanju, A., Barrera Briceno, L., Ferguson, R., . . . Costello-Goldring, E. (2016). UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis. Journal of Pathology, 238(3), 423-433. doi:10.1002/path.4665
2015
Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney
Shelton, L. M., Lister, A., Walsh, J., Jenkins, R. E., Wong, M. H. L., Rowe, C., . . . Copple, I. M. (2015). Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney. KIDNEY INTERNATIONAL, 88(06), 1261-1273. doi:10.1038/ki.2015.286
Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome
Eakins, R., Walsh, J., Randle, L., Jenkins, R. E., Schuppe-Koistinen, I., Rowe, C., . . . Park, B. K. (2015). Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome. SCIENTIFIC REPORTS, 5. doi:10.1038/srep16423
Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication
Sison-Young, R. L. C., Mitsa, D., Jenkins, R. E., Mottram, D., Alexandre, E., Richert, L., . . . Park, B. K. (2015). Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication. TOXICOLOGICAL SCIENCES, 147(2), 412-424. doi:10.1093/toxsci/kfv136
Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study
Lee, K. C. L., Baker, L. A., Stanzani, G., Alibhai, H., Mei Chang, Y., Palacios, C. J., . . . Jalan, R. (2015). Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study. Journal of Hepatology, 63(3), 634-642. doi:10.1016/j.jhep.2015.04.020
Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice
Cai, H., Scott, E., Kholghi, A., Andreadi, C., Rufini, A., Karmokar, A., . . . Brown, K. (2015). Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice. Science Translational Medicine, 7(298). doi:10.1126/scitranslmed.aaa7619
Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies
Heslop, J. A., Hammond, T. G., Santeramo, I., Piella, A. T., Hopp, I., Zhou, J., . . . Park, B. K. (2015). Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies. STEM CELLS TRANSLATIONAL MEDICINE, 4(4), 389-400. doi:10.5966/sctm.2014-0110
Understanding the Pathophysiological Regulatory Role of MicroRNAs in Acute Liver Failure
Antoine, D. J., Dear, J. W., Goldring, C. E., & Park, B. K. (2015). Understanding the Pathophysiological Regulatory Role of MicroRNAs in Acute Liver Failure. HEPATOLOGY, 61(4), 1439-1440. doi:10.1002/hep.27349
MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity
Kia, R., Kelly, L., Sison-Young, R. L. C., Zhang, F., Pridgeon, C. S., Heslop, J. A., . . . Park, B. K. (2015). MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity. Toxicological sciences : an official journal of the Society of Toxicology, 144(01), 173-185. doi:10.1093/toxsci/kfu269
Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes
Baxter, M., Withey, S., Harrison, S., Segeritz, C. -P., Zhang, F., Atkinson-Dell, R., . . . Hanley, N. A. (2015). Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes. Journal of Hepatology, 62(3), 581-589. doi:10.1016/j.jhep.2014.10.016
Proteomic analysis to identify biomarkers in the primary tumour that predict response to neoadjuvant chemotherapy in liver metastases
Sutton, P., Evans, J., Jones, R., Malik, H., Vimalachandran, D., Palmer, D., . . . Kitteringham, N. (2015). Proteomic analysis to identify biomarkers in the primary tumour that predict response to neoadjuvant chemotherapy in liver metastases. LANCET, 385, 95. Retrieved from https://www.webofscience.com/
Evaluation of a novel tissue stabilization gel to facilitate clinical sampling for translational research in surgical trials
Sutton, P. A., Jones, R. P., Morrison, F., Goldring, C. E., Park, B. K., Palmer, D. H., . . . Kitteringham, N. R. (2015). Evaluation of a novel tissue stabilization gel to facilitate clinical sampling for translational research in surgical trials. BRITISH JOURNAL OF SURGERY, 102(2), E124-E132. doi:10.1002/bjs.9678
Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.
Olayanju, A., Copple, I., Bryan, H. K., Edge, G. T., Sison-Young, R., Wong, M. W., . . . Park, K. (2015). Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.. Free Radical Biology & Medicine, 78, 202-212.
Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2
Olayanju, A., Copple, I. M., Bryan, H. K., Edge, G. T., Sison, R. L., Wong, M. W., . . . Park, B. K. (2015). Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2. Free Radical Biology and Medicine, 78, 202-212. doi:10.1016/j.freeradbiomed.2014.11.003
Understanding and Assessing the Risks of Stem Cell-Based Therapies
Heslop, J., Hammond, T. G., Santeramo, I., Tort Piella, A., Hopp, I., Zhou, J., . . . Park, B. (2015). Understanding and Assessing the Risks of Stem Cell-Based Therapies. Stem Cells Translational Medicine, 4, 389-400.
2014
The role of ERK5 in endothelial cell function
Nithianandarajah-Jones, G. N., Wilm, B., Goldring, C. E. P., Mueller, J., & Cross, M. J. (2014). The role of ERK5 in endothelial cell function. BIOCHEMICAL SOCIETY TRANSACTIONS, 42, 1584-1589. doi:10.1042/BST20140276
Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications
Walsh, J., Jenkins, R. E., Wong, M., Olayanju, A., Powell, H., Copple, I., . . . Park, B. K. (2014). Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications. JOURNAL OF PROTEOMICS, 108, 171-187. doi:10.1016/j.jprot.2014.05.007
Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids
Copple, I., Shelton, L. M., Walsh, J., Kratschmar, D. V., Lister, A., Odermatt, A., . . . Park, K. (2014). Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids. Toxicological Sciences, 140(2), 462-469. doi:10.1093/toxsci/kfu080
Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids
Copple, I. M., Shelton, L. M., Walsh, J., Kratschmar, D. V., Lister, A., Odermatt, A., . . . Park, B. K. (2014). Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids. Toxicological Sciences, 140(2), 462-469. doi:10.1093/toxsci/kfu080
Retro-orbital blood acquisition facilitates circulating microRNA measurement in zebrafish with paracetamol hepatotoxicity
Vliegenthart, A. D. B., Starkey Lewis, P., Tucker, C. S., Del Pozo, J., Rider, S., Antoine, D. J., . . . Dear, J. W. (2014). Retro-orbital blood acquisition facilitates circulating microRNA measurement in zebrafish with paracetamol hepatotoxicity. Zebrafish, 11(3), 219-226. doi:10.1089/zeb.2013.0912
Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis
Dear, J. W., Antoine, D. J., Starkey-Lewis, P., Goldring, C. E., & Park, B. K. (2014). Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 77(5), 904-905. doi:10.1111/bcp.12214
MicroRNAs as potential circulating biomarkers of drug-induced liver injury: key current and future issues for translation to humans
Hornby, R. J., Lewis, P. S., Dear, J., Goldring, C., & Park, B. K. (2014). MicroRNAs as potential circulating biomarkers of drug-induced liver injury: key current and future issues for translation to humans. EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 7(3), 349-362. doi:10.1586/17512433.2014.904201
2013
Safety pharmacology - Current and emerging concepts
Hamdam, J., Sethu, S., Smith, T., Alfirevic, A., Alhaidari, M., Atkinson, J., . . . Goldring, C. (2013). Safety pharmacology - Current and emerging concepts. TOXICOLOGY AND APPLIED PHARMACOLOGY, 273(2), 229-241. doi:10.1016/j.taap.2013.04.039
Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation.
Rowe, C., Gerrard, D. T., Jenkins, R., Berry, A., Durkin, K., Sundstrom, L., . . . Hanley, N. A. (2013). Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation.. Hepatology (Baltimore, Md.), 58(2), 799-809. doi:10.1002/hep.26414
The S349T mutation of <i>SQSTM1</i> links Keap1/Nrf2 signalling to Paget's disease of bone
Wright, T., Rea, S. L., Goode, A., Bennett, A. J., Ratajczak, T., Long, J. E., . . . Layfield, R. (2013). The S349T mutation of <i>SQSTM1</i> links Keap1/Nrf2 signalling to Paget's disease of bone. BONE, 52(2), 699-706. doi:10.1016/j.bone.2012.10.023
2012
Analysis of the rat primary hepatocyte nuclear proteome through sub-cellular fractionation
Goldring, C., Rowe, C., Jenkins, R. E., Kitteringham, N. R., & Park, K. B. (n.d.). Analysis of the rat primary hepatocyte nuclear proteome through sub-cellular fractionation. Journal of Integrated OMICS, 2(2). doi:10.5584/jiomics.v2i2.102
ERK5: Structure, regulation and function
Nithianandarajah-Jones, G. N., Wilm, B., Goldring, C. E. P., Mueller, J., & Cross, M. J. (2012). ERK5: Structure, regulation and function. CELLULAR SIGNALLING, 24(11), 2187-2196. doi:10.1016/j.cellsig.2012.07.007
Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells.
Yeang, H. X. A., Hamdam, J. M., Al-Huseini, L. M. A., Sethu, S., Djouhri, L., Walsh, J., . . . Sathish, J. G. (2012). Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells.. The Journal of biological chemistry, 287(13), 10556-10564. doi:10.1074/jbc.m111.322420
Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics.
Abdullah, A., Kitteringham, N. R., Jenkins, R. E., Goldring, C., Higgins, L., Yamamoto, M., . . . Park, B. K. (2012). Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics.. Pharmacological reports : PR, 64(3), 680-697. doi:10.1016/s1734-1140(12)70863-0
2011
Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy
Lister, A., Nedjadi, T., Kitteringham, N. R., Campbell, F., Costello, E., Lloyd, B., . . . Park, B. K. (2011). Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. Molecular Cancer, 10(1). doi:10.1186/1476-4598-10-37
Circulating MicroRNAs as Potential Markers of Human Drug-Induced Liver Injury
Lewis, P. J. S., Dear, J., Platt, V., Simpson, K. J., Craig, D. G. N., Antoine, D. J., . . . Park, B. K. (2011). Circulating MicroRNAs as Potential Markers of Human Drug-Induced Liver Injury. HEPATOLOGY, 54(5), 1767-1776. doi:10.1002/hep.24538
Tetracycline-inducible protein expression in pancreatic cancer cells: Effects of CapG overexpression
Tonack, S., Patel, S., Jalali, M., Nedjadi, T., Jenkins, R. E., Goldring, C., . . . Costello, E. (2011). Tetracycline-inducible protein expression in pancreatic cancer cells: Effects of CapG overexpression. WORLD JOURNAL OF GASTROENTEROLOGY, 17(15), 1947-1960. doi:10.3748/wjg.v17.i15.1947
Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy
Lister, A., Nedjadi, T., Kitteringham, N. R., Campbell, F., Costello, E., Lloyd, B., . . . Park, B. K. (2011). Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. MOLECULAR CANCER, 10. doi:10.1186/1476-4598-10-37
Assessing the safety of stem cell therapeutics
Goldring, C., Duffy, P. A., Benvenisty, N., Andrews, P. W., Ben-David, U., Eakins, R., . . . Park, K. (2011). Assessing the safety of stem cell therapeutics. Cell Stem Cell, 8(6), 618-628.
Assessing the safety of stem cell therapeutics.
Goldring, C., Duffy, P. A., Benvenisty, N., Andrews, P. W., Ben-David, U., Eakins, R., . . . Park, B. K. (2011). Assessing the safety of stem cell therapeutics.. Unknown Journal, 618-628.
Managing the Challenge of Chemically Reactive Metabolites in Drug Development.
Park, B. K., Boobis, A., Clarke, S., Goldring, C., Jones, D., Kenna, G., . . . Baillie, T. A. (2011). Managing the Challenge of Chemically Reactive Metabolites in Drug Development.. Unknown Journal, 292-306.
Managing the challenge of chemically reactive metabolites in drug development.
Park, B. K., Boobis, A., Clarke, S., Goldring, C., Jones, D., Kenna, J. G., . . . Baillie, T. A. (2011). Managing the challenge of chemically reactive metabolites in drug development.. Nature Reviews Drug Discovery, 10(4), 292-306.
Novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3
Bone, T., & Goldring, C. (2011). Novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3. J. Cell Science, In press.
Nrf2 is over-expressed in pancreatic cancer: implications for cell proliferation and therapy
Lister, A., Nedjadi, T., Kitteringham, N. R., Campbell, F., Costello, E., Lloyd, B., . . . Park, B. K. (2011). Nrf2 is over-expressed in pancreatic cancer: implications for cell proliferation and therapy. Molecular Cancer, 10, 37.
miRNAs in biofluids as markers of human drug-induced liver injury
Starkey-Lewis, P. J., Dear, J., Platt, V., Simpson, K. J., Craig, D. G. N., Antoine, D. J., . . . Park, B. K. (2011). miRNAs in biofluids as markers of human drug-induced liver injury. Hepatology, In Press.
2010
Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB
Chia, A. J. L., Goldring, C. E., Kitteringham, N. R., Wong, S. Q., Morgan, P., & Park, B. K. (2010). Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB. BIOCHEMICAL PHARMACOLOGY, 80(3), 410-421. doi:10.1016/j.bcp.2010.04.004
Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening
Baxter, M. A., Rowe, C., Alder, J., Harrison, S., Hanley, K. P., Park, B. K., . . . Hanley, N. A. (2010). Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening. Stem Cell Research, 5(1), 4-22. doi:10.1016/j.scr.2010.02.002
Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening.
Baxter, M. A., Rowe, C., Alder, J., Harrison, S., Hanley, K. P., Park, B. K., . . . Hanley, N. A. (2010). Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening.. Stem cell research, 5(1), 4-22. doi:10.1016/j.scr.2010.02.002
Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver
Kitteringham, N. R., Abdullah, A., Walsh, J., Randle, L., Jenkins, R. E., Sison, R., . . . Park, B. K. (2010). Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver. JOURNAL OF PROTEOMICS, 73(8), 1612-1631. doi:10.1016/j.jprot.2010.03.018
Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway
Copple, I. M., Lister, A., Obeng, A. D., Kitteringham, N. R., Jenkins, R. E., Layfield, R., . . . Park, B. K. (2010). Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(22), 16782-16788. doi:10.1074/jbc.M109.096545
Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach.
Rowe, C., Goldring, C. E. P., Kitteringham, N. R., Jenkins, R. E., Lane, B. S., Sanderson, C., . . . Park, B. K. (2010). Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach.. Journal of proteome research, 9(5), 2658-2668. doi:10.1021/pr1001687
The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity.
Copple, I. M., Goldring, C. E., Kitteringham, N. R., & Park, B. K. (2010). The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity.. Handbook of experimental pharmacology, (196), 233-266. doi:10.1007/978-3-642-00663-0_9
The Keap1-Nrf2 cellular defense pathway: Mechanisms of regulation and role in protection against drug-induced toxicity
Copple, I., Goldring, C., Kitteringham, N., & Park, K. (2010). The Keap1-Nrf2 cellular defense pathway: Mechanisms of regulation and role in protection against drug-induced toxicity. Handbook of Experimental Pharmacology, 196, 233-266.
2009
Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1
Megherbi, R., Kiorpelidou, E., Foster, B., Rowe, C., Naisbitt, D. J., Goldring, C. E., & Park, B. K. (2009). Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1. Toxicology and Applied Pharmacology, 238(2), 120-132. doi:10.1016/j.taap.2009.05.001
Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1
Megherbi, R., Kiorpelidou, E., Foster, B., Rowe, C., Naisbitt, D. J., Goldring, C. E., & Park, B. K. (2009). Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1. TOXICOLOGY AND APPLIED PHARMACOLOGY, 238(2), 120-132. doi:10.1016/j.taap.2009.05.001
Extract of <i>Ginkgo biloba</i> induces glutathione-S-transferase subunit-P1 <i>in vitro</i>
Liu, X. -P., Goldring, C. E. P., Wang, H. -Y., Copple, I. M., Kitteringham, N. R., & Park, B. K. (2009). Extract of <i>Ginkgo biloba</i> induces glutathione-S-transferase subunit-P1 <i>in vitro</i>. PHYTOMEDICINE, 16(5), 451-455. doi:10.1016/j.phymed.2008.11.001
An Investigation of the expression of cytochrome P450 3A7 and cytochrome P450 3A4 during stem cell differentiation for use as markers of emerging hepatic phenotype
Curley, P., Kelly, L., Shaw, R., Kitteringham, N., Jenkins, R., Alder, J., . . . Park, K. (2009). An Investigation of the expression of cytochrome P450 3A7 and cytochrome P450 3A4 during stem cell differentiation for use as markers of emerging hepatic phenotype. In British Pharmacology Society Winter Meeting. London, UK.
Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells.
Ignatova, I. D., Kostadinova, R. M., Goldring, C. E., Nawrocki, A. R., Frey, F. J., & Frey, B. M. (2009). Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells.. Am J Physiol Endocrinol Metab.
2008
The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system
Copple, I. M., Goldring, C. E., Jenkins, R. E., Chia, A. J. L., Randle, L. E., Hayes, J. D., . . . Park, B. K. (2008). The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system. HEPATOLOGY, 48(4), 1292-1301. doi:10.1002/hep.22472
The Nrf2-Keapl defence pathway: Role in protection against drug-induced toxicity
Copple, I. M., Goldring, C. E., Kitteringham, N. R., & Park, B. K. (2008). The Nrf2-Keapl defence pathway: Role in protection against drug-induced toxicity. TOXICOLOGY, 246(1), 24-33. doi:10.1016/j.tox.2007.10.029
Extract of <i>Ginkgo biloba</i> induces glutamate cysteine ligase catalytic subunit (GCLC)
Liu, X. -P., Goldring, C. E. P., Wang, H. -Y., Copple, I. M., Kitteringharn, N. R., Park, B. K., & Wei, W. (2008). Extract of <i>Ginkgo biloba</i> induces glutamate cysteine ligase catalytic subunit (GCLC). PHYTOTHERAPY RESEARCH, 22(3), 367-371. doi:10.1002/ptr.2328
Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites.
Jenkins, R. E., Kitteringham, N. R., Goldring, C. E. P., Dowdall, S. M. J., Hamlett, J., Lane, C. S., . . . Park, B. K. (2008). Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites.. Proteomics, 8(2), 301-315. doi:10.1002/pmic.200700843
The Nrf2-Keap1 defence pathway: Role in protection against drug-induced toxicity
Copple, I., Goldring, C., Kitteringham, N., & Park, K. (2008). The Nrf2-Keap1 defence pathway: Role in protection against drug-induced toxicity. Toxicology, 246, 24-33.
2007
Detection and biochemical characterisation of a novel polymorphism in the human <i>GSTP1</i> gene
Kitteringham, N. R., Palmer, L., Owen, A., Lian, L. -Y., Jenkins, R., Dowdall, S., . . . Goldring, C. E. (2007). Detection and biochemical characterisation of a novel polymorphism in the human <i>GSTP1</i> gene. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1770(8), 1240-1247. doi:10.1016/j.bbagen.2007.05.001
Extract of <i>Ginkgo biloba</i> induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway
Liu, X. -P., Goldring, C. E. P., Copple, I. M., Wang, H. -Y., Wei, W., Kitteringham, N. R., & Park, B. K. (2007). Extract of <i>Ginkgo biloba</i> induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway. LIFE SCIENCES, 80(17), 1586-1591. doi:10.1016/j.lfs.2007.01.034
Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway
Liu, X. -P., Goldring, C. E. P., Copple, I. M., Wang, H. -Y., Wei, W., Kitteringham, N. R., & Park, B. K. (2007). Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway. Life Sciences, 80(17), 1586-1591. doi:10.1016/j.lfs.2007.01.034
Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice.
Randle, L. E., Goldring, C., Benson, C. A., Metcalfe, P. N., Kitteringham, N. R., Park, B. K., & Williams, D. P. (2007). Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice.. Toxicology.
2006
Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elements
Owen, A., Goldring, C., Morgan, P., Park, B. K., & Pirmohamed, M. (2006). Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elements. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 62(2), 237-242. doi:10.1111/j.1365-2125.2006.02587.x
Plasticity in cell defence: access to and reactivity of critical protein residues and DNA response elements
Goldring, C., Kitteringham, N., Jenkins, R., Copple, I., Jeannin, J. F., & Park, B. K. (2006). Plasticity in cell defence: access to and reactivity of critical protein residues and DNA response elements. JOURNAL OF EXPERIMENTAL BIOLOGY, 209(12), 2337-2343. doi:10.1242/jeb.02209
Activation of the Nrf2/are antioxidant pathway by N-acetyl-p-benzoquinoneimine (NAPQI)
Copple, I. M., Goldring, C., Jenkins, R., Kitteringham, N., & Park, B. K. (2006). Activation of the Nrf2/are antioxidant pathway by N-acetyl-p-benzoquinoneimine (NAPQI). Drug Metabolism Reviews, 38, 49.
Analysis of inter-individual variation in the Nrf2/Keap1 genes responsible for induction of the antioxidant response
Wang, H., Goldring, C., Kitteringham, N., & Park, B. K. (2006). Analysis of inter-individual variation in the Nrf2/Keap1 genes responsible for induction of the antioxidant response. Drug Metabolism Reviews, 38, 84-85.
Chemical modification of glutathione S-transferase PI: A model for characterization of chemically reactive metabolites
Jenkins, R., Kitteringham, N., Goldring, C., Metcalfe, P., Dowdall, S., & Park, B. K. (2006). Chemical modification of glutathione S-transferase PI: A model for characterization of chemically reactive metabolites. Drug Metabolism Reviews, 38, 154-155.
Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes
Goldring, C. E. P., Kitteringham, N. R., Jenkins, R., Lovatt, C. A., Randle, L. E., Abdullah, A., . . . Park, B. K. (2006). Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 290(1), C104-C115. doi:10.1152/ajpcell.00133.2005
Mechanisms of defence during chemical-induced hepatotoxicity
Randle, L. E., Williams, D. P., Goldring, C., & Park, B. K. (2006). Mechanisms of defence during chemical-induced hepatotoxicity. Drug Metabolism Reviews, 38, 56-58.
Pharmacogenetic and functional analysis of a novel GSTP1 polymorphism
Palmer, L., Goldring, C., Kitteringham, N., Owen, A., Gilmore, I., & Park, K. (2006). Pharmacogenetic and functional analysis of a novel GSTP1 polymorphism. Drug Metabolism Reviews, 38, 91.
Tetracycline-inducible pancreatic cancer cell lines
Patel, S. I., Bier, M., Goldring, C., Hillen, W., & Costello, E. (2006). Tetracycline-inducible pancreatic cancer cell lines. Pancreas, 33(4), 489.
2005
Relationship between the C<sub>3435</sub>T and G<sub>2677</sub>T(A) polymorphisms in the <i>ABCB1</i> gene and P-glycoprotein expression in human liver
Owen, A., Goldring, C., Morgan, P., Chadwick, D., Park, B. K., & Pirmohamed, M. (2005). Relationship between the C<sub>3435</sub>T and G<sub>2677</sub>T(A) polymorphisms in the <i>ABCB1</i> gene and P-glycoprotein expression in human liver. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(3), 365-370. doi:10.1111/j.1365-2125.2005.02229.x
Interindividual variation in the expression of the cellular redox sensor Keap1 and its novel splice variants in human lymphocytes
Abdullah, A., Goldring, C., Owen, A., Kitteringham, N., & Park, K. (2005). Interindividual variation in the expression of the cellular redox sensor Keap1 and its novel splice variants in human lymphocytes. Toxicology, 213(3), 261-262.
Proteomic analysis of liver protein expression in transgenic mice deficient in the transcription factor Nrf2
Kitteringham, N., Abdullah, A., Jenkins, R., Goldring, C., Hayes, J. D., & Park, K. (2005). Proteomic analysis of liver protein expression in transgenic mice deficient in the transcription factor Nrf2. Drug Metabolism Reviews, 37, 23.
2004
Activation of hepatic Nrf2 <i>in vivo</i> by acetaminophen in CD-1 mice
Goldring, C. E. P., Kitteringham, N. R., Elsby, R., Randle, L. E., Clement, Y. N., Williams, D. P., . . . Park, B. K. (2004). Activation of hepatic Nrf2 <i>in vivo</i> by acetaminophen in CD-1 mice. HEPATOLOGY, 39(5), 1267-1276. doi:10.1002/hep.20183
2003
Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi.
Elsby, R., Kitteringham, N. R., Goldring, C. E., Lovatt, C. A., Chamberlain, M., Henderson, C. J., . . . Park, B. K. (2003). Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi.. The Journal of biological chemistry, 278(25), 22243-22249. doi:10.1074/jbc.m301211200
2002
In vivo footprinting of the human 11beta-hydroxysteroid dehydrogenase type 2 promoter: evidence for cell-specific regulation by Sp1 and Sp3.
Nawrocki, A. R., Goldring, C. E., Kostadinova, R. M., Frey, F. J., & Frey, B. M. (2002). In vivo footprinting of the human 11beta-hydroxysteroid dehydrogenase type 2 promoter: evidence for cell-specific regulation by Sp1 and Sp3.. The Journal of biological chemistry, 277(17), 14647-14656. doi:10.1074/jbc.m111549200
2000
Heat shock enhances transcriptional activation of the murine-inducible nitric oxide synthase gene.
Goldring, C. E., Reveneau, S., Chantome, A., Pance, A., Fleury, C., Hume, D. A., . . . Jeannin, J. F. (2000). Heat shock enhances transcriptional activation of the murine-inducible nitric oxide synthase gene.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 14(15), 2393-2395. doi:10.1096/fj.98-0509fje