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Professor Christopher Goldring
BSc, PhD

Professor, Deputy Executive Dean of the Institute for Systems, Molecular and Integrative Biology
Pharmacology & Therapeutics

Publications

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2023

Study design for development of novel safety biomarkers of drug-induced liver injury by the translational safety biomarker pipeline (TransBioLine) consortium: a study protocol for a nested case-control study.

Grove, J. I., Stephens, C., Lucena, M. I., Andrade, R. J., Weber, S., Gerbes, A., . . . TransBioLine consortium. (2023). Study design for development of novel safety biomarkers of drug-induced liver injury by the translational safety biomarker pipeline (TransBioLine) consortium: a study protocol for a nested case-control study.. Diagnostic and prognostic research, 7(1), 18. doi:10.1186/s41512-023-00155-z

DOI
10.1186/s41512-023-00155-z
Journal article

In Vivo Tumorigenicity of the 20q11.21 Amplicon in an Engraftment Model of hPSCs and Differentiated Liver Cells

Pridgeon, C. S., Forootan, S. S., Zhang, F., Harper, N., Palmer, D., Weightmann, R., . . . Goldring, C. E. P. (2023). In Vivo Tumorigenicity of the 20q11.21 Amplicon in an Engraftment Model of hPSCs and Differentiated Liver Cells. JOURNAL OF STEM CELLS & REGENERATIVE MEDICINE, 19(1), P2-P12. doi:10.46582/jsrm.1901002

DOI
10.46582/jsrm.1901002
Journal article

VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells

Mondru, A. K., Aljasir, M. A., Alrumayh, A., Nithianandarajah, G. N., Ahmed, K., Muller, J., . . . Cross, M. J. (2023). VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells. CELLS, 12(6). doi:10.3390/cells12060967

DOI
10.3390/cells12060967
Journal article

2022

A MicroRNA Next-Generation-Sequencing Discovery Assay (miND) for Genome-Scale Analysis and Absolute Quantitation of Circulating MicroRNA Biomarkers

Khamina, K., Diendorfer, A. B., Skalicky, S., Weigl, M., Pultar, M., Krammer, T. L., . . . Hackl, M. (2022). A MicroRNA Next-Generation-Sequencing Discovery Assay (miND) for Genome-Scale Analysis and Absolute Quantitation of Circulating MicroRNA Biomarkers. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(3). doi:10.3390/ijms23031226

DOI
10.3390/ijms23031226
Journal article

2021

Systems analysis of miRNA biomarkers to inform drug safety

Schofield, A. L., Brown, J. P., Brown, J., Wilczynska, A., Bell, C., Glaab, W. E., . . . Goldring, C. (2021). Systems analysis of miRNA biomarkers to inform drug safety. ARCHIVES OF TOXICOLOGY, 95(11), 3475-3495. doi:10.1007/s00204-021-03150-9

DOI
10.1007/s00204-021-03150-9
Journal article

2020

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

Weaver, R. J., Blomme, E. A., Chadwick, A. E., Copple, I. M., Gerets, H. H. J., Goldring, C. E., . . . Park, B. K. (2020). Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models. NATURE REVIEWS DRUG DISCOVERY, 19(2), 131-148. doi:10.1038/s41573-019-0048-x

DOI
10.1038/s41573-019-0048-x
Journal article

2019

Stem cell models as an <i>in vitro</i> model for predictive toxicology

Lynch, S., Pridgeon, C. S., Duckworth, C. A., Sharma, P., Park, B. K., & Goldring, C. E. P. (2019). Stem cell models as an <i>in vitro</i> model for predictive toxicology. BIOCHEMICAL JOURNAL, 476, 1149-1158. doi:10.1042/BCJ20170780

DOI
10.1042/BCJ20170780
Journal article

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Copple, I. M., den Hollander, W., Callegaro, G., Mutter, F. E., Maggs, J. L., Schofield, A. L., . . . Park, B. K. (2019). Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury. Archives of Toxicology, 93, 385-399. doi:10.1007/s00204-018-2354-1

DOI
10.1007/s00204-018-2354-1
Journal article

Application of porcine gastrointestinal organoid units as a potential in vitro tool for drug discovery and development

Olayanju, A., Jones, L., Greco, K., Goldring, C. E., & Ansari, T. (2019). Application of porcine gastrointestinal organoid units as a potential in vitro tool for drug discovery and development. JOURNAL OF APPLIED TOXICOLOGY, 39(1), 4-15. doi:10.1002/jat.3641

DOI
10.1002/jat.3641
Journal article

2018

Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds

Oppelt, A., Kaschek, D., Huppelschoten, S., Sison-Young, R., Zhang, F., Buck-Wiese, M., . . . Klingmueuler, U. (2018). Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds. NPJ SYSTEMS BIOLOGY AND APPLICATIONS, 4. doi:10.1038/s41540-018-0058-z

DOI
10.1038/s41540-018-0058-z
Journal article

Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins

Rowe, C., Shaeri, M., Large, E., Cornforth, T., Robinson, A., Kostrzewski, T., . . . Hughes, D. (2018). Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins. TOXICOLOGY IN VITRO, 46, 29-38. doi:10.1016/j.tiv.2017.09.012

DOI
10.1016/j.tiv.2017.09.012
Journal article

Exome sequencing of synchronously resected primary colorectal tumours and colorectal liver metastases to inform oncosurgical management

Sutton, P. A., Jithesh, P. V., Jones, R. P., Evans, J. P., Vimalachandran, D., Malik, H. Z., . . . Kitteringham, N. R. (2018). Exome sequencing of synchronously resected primary colorectal tumours and colorectal liver metastases to inform oncosurgical management. EJSO - European Journal of Surgical Oncology, 44(1), 115-121. doi:10.1016/j.ejso.2017.10.211

DOI
10.1016/j.ejso.2017.10.211
Journal article

Leading-Edge Approaches for In Vitro Hepatotoxicity Evaluation

LeCluyse, E. L., Norona, L. M., Akingbasote, J. A., Howell, L. S., Woodhead, J. L., Cross, M. J., . . . Goldring, C. E. (2018). Leading-Edge Approaches for In Vitro Hepatotoxicity Evaluation. In Comprehensive Toxicology (pp. 651-712). Elsevier. doi:10.1016/b978-0-12-801238-3.64267-8

DOI
10.1016/b978-0-12-801238-3.64267-8
Chapter

Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testing

Wong, M. W., Pridgeon, C. S., Schlott, C., Park, B. K., & Goldring, C. E. P. (2018). Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testing. In DRUG-INDUCED LIVER TOXICITY (pp. 199-212). doi:10.1007/978-1-4939-7677-5_10

DOI
10.1007/978-1-4939-7677-5_10
Chapter

2017

Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo

Brillant, N., Elmasry, M., Burton, N. C., Rodriguez, J. M., Sharkey, J. W., Fenwick, S., . . . Antoine, D. J. (2017). Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo. TOXICOLOGY AND APPLIED PHARMACOLOGY, 332, 64-74. doi:10.1016/j.taap.2017.07.019

DOI
10.1016/j.taap.2017.07.019
Journal article

Donor-Dependent and Other Nondefined Factors have Greater Influence on the Hepatic Phenotype than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells (vol 6, 1751, 2017)

Heslop, J. A., Kia, R., Pridgeon, C. S., Sison-Young, R. L., Liloglou, T., Elmasry, M., . . . Park, B. K. (2017). Donor-Dependent and Other Nondefined Factors have Greater Influence on the Hepatic Phenotype than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells (vol 6, 1751, 2017). STEM CELLS TRANSLATIONAL MEDICINE, 6(8). Retrieved from https://www.webofscience.com/

Journal article

Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development

Goldring, C., Weaver, R., Kramer, B., Klingmueller, U., Oppelt, A., Van der Water, B., . . . Park, B. K. (2017). Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development. In COMPREHENSIVE MEDICINAL CHEMISTRY III, VOL 4: EXPERIMENTAL ADME AND TOXICOLOGY (pp. 217-238). doi:10.1016/B978-0-12-409547-2.12384-4

DOI
10.1016/B978-0-12-409547-2.12384-4
Chapter

Donor‐Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte‐Like Cells

Heslop, J., Kia, R., Pridgeon, C., Sison-Young, R., Liloglou, T., Elmasry, M., . . . Park, B. K. (2017). Donor‐Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte‐Like Cells. Stem Cells Translational Medicine, 6(5), 1321-1331. doi:10.1002/sctm.16-0029

DOI
10.1002/sctm.16-0029
Journal article

Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo.

Sharkey, J., Starkey Lewis, P. J., Barrow, M., Alwahsh, S. M., Noble, J., Livingstone, E., . . . Park, B. K. (2017). Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo.. Cytotherapy, 19(4), 555-569. doi:10.1016/j.jcyt.2017.01.003

DOI
10.1016/j.jcyt.2017.01.003
Journal article

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

Sison-Young, R. L., Lauschke, V. M., Johann, E., Alexandre, E., Antherieu, S., Aerts, H., . . . Park, B. K. (2017). A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity. Archives of Toxicology, 91(3), 1385-1400. doi:10.1007/s00204-016-1745-4

DOI
10.1007/s00204-016-1745-4
Journal article

Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile

Heslop, J. A., Rowe, C., Walsh, J., Sison-Young, R., Jenkins, R., Kamalian, L., . . . Kevin Park, B. (2017). Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile. Archives of Toxicology, 91(1), 439-452. doi:10.1007/s00204-016-1694-y

DOI
10.1007/s00204-016-1694-y
Journal article

2016

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

Lauschke, V. M., Vorrink, S. U., Moro, S. M. L., Rezayee, F., Nordling, A., Hendriks, D. F. G., . . . Ingelman-Sundberg, M. (2016). Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation. HEPATOLOGY, 64(5), 1743-1756. doi:10.1002/hep.28780

DOI
10.1002/hep.28780
Journal article

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

Bell, C. C., Hendriks, D. F. G., Moro, S. M. L., Ellis, E., Walsh, J., Renblom, A., . . . Ingelman-Sundberg, M. (2016). Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease. Scientific Reports, 6. doi:10.1038/srep25187

DOI
10.1038/srep25187
Journal article

Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites

Wong, M. H. L., Bryan, H. K., Copple, I. M., Jenkins, R. E., Chiu, P. H., Bibby, J., . . . Park, B. K. (2016). Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites. JOURNAL OF MEDICINAL CHEMISTRY, 59(6), 2396-2409. doi:10.1021/acs.jmedchem.5b01292

DOI
10.1021/acs.jmedchem.5b01292
Journal article

UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis

Abu-Alainin, W., Gana, T., Liloglou, L., Olayanju, A., Barrera Briceno, L., Ferguson, R., . . . Costello-Goldring, E. (2016). UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis. Journal of Pathology, 238(3), 423-433. doi:10.1002/path.4665

DOI
10.1002/path.4665
Journal article

2015

Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome

Eakins, R., Walsh, J., Randle, L., Jenkins, R. E., Schuppe-Koistinen, I., Rowe, C., . . . Park, B. K. (2015). Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome. SCIENTIFIC REPORTS, 5. doi:10.1038/srep16423

DOI
10.1038/srep16423
Journal article

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

Sison-Young, R. L. C., Mitsa, D., Jenkins, R. E., Mottram, D., Alexandre, E., Richert, L., . . . Park, B. K. (2015). Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication. TOXICOLOGICAL SCIENCES, 147(2), 412-424. doi:10.1093/toxsci/kfv136

DOI
10.1093/toxsci/kfv136
Journal article

Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study

Lee, K. C. L., Baker, L. A., Stanzani, G., Alibhai, H., Mei Chang, Y., Palacios, C. J., . . . Jalan, R. (2015). Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study. Journal of Hepatology, 63(3), 634-642. doi:10.1016/j.jhep.2015.04.020

DOI
10.1016/j.jhep.2015.04.020
Journal article

Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice

Cai, H., Scott, E., Kholghi, A., Andreadi, C., Rufini, A., Karmokar, A., . . . Brown, K. (2015). Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice. Science Translational Medicine, 7(298). doi:10.1126/scitranslmed.aaa7619

DOI
10.1126/scitranslmed.aaa7619
Journal article

Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies

Heslop, J. A., Hammond, T. G., Santeramo, I., Piella, A. T., Hopp, I., Zhou, J., . . . Park, B. K. (2015). Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies. STEM CELLS TRANSLATIONAL MEDICINE, 4(4), 389-400. doi:10.5966/sctm.2014-0110

DOI
10.5966/sctm.2014-0110
Journal article

Understanding the Pathophysiological Regulatory Role of MicroRNAs in Acute Liver Failure

Antoine, D. J., Dear, J. W., Goldring, C. E., & Park, B. K. (2015). Understanding the Pathophysiological Regulatory Role of MicroRNAs in Acute Liver Failure. HEPATOLOGY, 61(4), 1439-1440. doi:10.1002/hep.27349

DOI
10.1002/hep.27349
Journal article

MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity

Kia, R., Kelly, L., Sison-Young, R. L. C., Zhang, F., Pridgeon, C. S., Heslop, J. A., . . . Park, B. K. (2015). MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity. Toxicological sciences : an official journal of the Society of Toxicology, 144(01), 173-185. doi:10.1093/toxsci/kfu269

DOI
10.1093/toxsci/kfu269
Journal article

Proteomic analysis to identify biomarkers in the primary tumour that predict response to neoadjuvant chemotherapy in liver metastases

Sutton, P., Evans, J., Jones, R., Malik, H., Vimalachandran, D., Palmer, D., . . . Kitteringham, N. (2015). Proteomic analysis to identify biomarkers in the primary tumour that predict response to neoadjuvant chemotherapy in liver metastases. LANCET, 385, 95. Retrieved from https://www.webofscience.com/

Journal article

Evaluation of a novel tissue stabilization gel to facilitate clinical sampling for translational research in surgical trials

Sutton, P. A., Jones, R. P., Morrison, F., Goldring, C. E., Park, B. K., Palmer, D. H., . . . Kitteringham, N. R. (2015). Evaluation of a novel tissue stabilization gel to facilitate clinical sampling for translational research in surgical trials. BRITISH JOURNAL OF SURGERY, 102(2), E124-E132. doi:10.1002/bjs.9678

DOI
10.1002/bjs.9678
Journal article

Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.

Olayanju, A., Copple, I., Bryan, H. K., Edge, G. T., Sison-Young, R., Wong, M. W., . . . Park, K. (2015). Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.. Free Radical Biology & Medicine, 78, 202-212.

Journal article

Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2

Olayanju, A., Copple, I. M., Bryan, H. K., Edge, G. T., Sison, R. L., Wong, M. W., . . . Park, B. K. (2015). Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2. Free Radical Biology and Medicine, 78, 202-212. doi:10.1016/j.freeradbiomed.2014.11.003

DOI
10.1016/j.freeradbiomed.2014.11.003
Journal article

Understanding and Assessing the Risks of Stem Cell-Based Therapies

Heslop, J., Hammond, T. G., Santeramo, I., Tort Piella, A., Hopp, I., Zhou, J., . . . Park, B. (2015). Understanding and Assessing the Risks of Stem Cell-Based Therapies. Stem Cells Translational Medicine, 4, 389-400.

Journal article

2014

The role of ERK5 in endothelial cell function

Nithianandarajah-Jones, G. N., Wilm, B., Goldring, C. E. P., Mueller, J., & Cross, M. J. (2014). The role of ERK5 in endothelial cell function. BIOCHEMICAL SOCIETY TRANSACTIONS, 42, 1584-1589. doi:10.1042/BST20140276

DOI
10.1042/BST20140276
Journal article

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications

Walsh, J., Jenkins, R. E., Wong, M., Olayanju, A., Powell, H., Copple, I., . . . Park, B. K. (2014). Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications. JOURNAL OF PROTEOMICS, 108, 171-187. doi:10.1016/j.jprot.2014.05.007

DOI
10.1016/j.jprot.2014.05.007
Journal article

Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids

Copple, I., Shelton, L. M., Walsh, J., Kratschmar, D. V., Lister, A., Odermatt, A., . . . Park, K. (2014). Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids. Toxicological Sciences, 140(2), 462-469. doi:10.1093/toxsci/kfu080

DOI
10.1093/toxsci/kfu080
Journal article

Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids

Copple, I. M., Shelton, L. M., Walsh, J., Kratschmar, D. V., Lister, A., Odermatt, A., . . . Park, B. K. (2014). Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids. Toxicological Sciences, 140(2), 462-469. doi:10.1093/toxsci/kfu080

DOI
10.1093/toxsci/kfu080
Journal article

Retro-orbital blood acquisition facilitates circulating microRNA measurement in zebrafish with paracetamol hepatotoxicity

Vliegenthart, A. D. B., Starkey Lewis, P., Tucker, C. S., Del Pozo, J., Rider, S., Antoine, D. J., . . . Dear, J. W. (2014). Retro-orbital blood acquisition facilitates circulating microRNA measurement in zebrafish with paracetamol hepatotoxicity. Zebrafish, 11(3), 219-226. doi:10.1089/zeb.2013.0912

DOI
10.1089/zeb.2013.0912
Journal article

Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis

Dear, J. W., Antoine, D. J., Starkey-Lewis, P., Goldring, C. E., & Park, B. K. (2014). Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 77(5), 904-905. doi:10.1111/bcp.12214

DOI
10.1111/bcp.12214
Journal article

MicroRNAs as potential circulating biomarkers of drug-induced liver injury: key current and future issues for translation to humans

Hornby, R. J., Lewis, P. S., Dear, J., Goldring, C., & Park, B. K. (2014). MicroRNAs as potential circulating biomarkers of drug-induced liver injury: key current and future issues for translation to humans. EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 7(3), 349-362. doi:10.1586/17512433.2014.904201

DOI
10.1586/17512433.2014.904201
Journal article

2013

Safety pharmacology - Current and emerging concepts

Hamdam, J., Sethu, S., Smith, T., Alfirevic, A., Alhaidari, M., Atkinson, J., . . . Goldring, C. (2013). Safety pharmacology - Current and emerging concepts. TOXICOLOGY AND APPLIED PHARMACOLOGY, 273(2), 229-241. doi:10.1016/j.taap.2013.04.039

DOI
10.1016/j.taap.2013.04.039
Journal article

The S349T mutation of <i>SQSTM1</i> links Keap1/Nrf2 signalling to Paget's disease of bone

Wright, T., Rea, S. L., Goode, A., Bennett, A. J., Ratajczak, T., Long, J. E., . . . Layfield, R. (2013). The S349T mutation of <i>SQSTM1</i> links Keap1/Nrf2 signalling to Paget's disease of bone. BONE, 52(2), 699-706. doi:10.1016/j.bone.2012.10.023

DOI
10.1016/j.bone.2012.10.023
Journal article

2012

Analysis of the rat primary hepatocyte nuclear proteome through sub-cellular fractionation

Goldring, C., Rowe, C., Jenkins, R. E., Kitteringham, N. R., & Park, K. B. (n.d.). Analysis of the rat primary hepatocyte nuclear proteome through sub-cellular fractionation. Journal of Integrated OMICS, 2(2). doi:10.5584/jiomics.v2i2.102

DOI
10.5584/jiomics.v2i2.102
Journal article

ERK5: Structure, regulation and function

Nithianandarajah-Jones, G. N., Wilm, B., Goldring, C. E. P., Mueller, J., & Cross, M. J. (2012). ERK5: Structure, regulation and function. CELLULAR SIGNALLING, 24(11), 2187-2196. doi:10.1016/j.cellsig.2012.07.007

DOI
10.1016/j.cellsig.2012.07.007
Journal article

Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells.

Yeang, H. X. A., Hamdam, J. M., Al-Huseini, L. M. A., Sethu, S., Djouhri, L., Walsh, J., . . . Sathish, J. G. (2012). Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells.. The Journal of biological chemistry, 287(13), 10556-10564. doi:10.1074/jbc.m111.322420

DOI
10.1074/jbc.m111.322420
Journal article

Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics.

Abdullah, A., Kitteringham, N. R., Jenkins, R. E., Goldring, C., Higgins, L., Yamamoto, M., . . . Park, B. K. (2012). Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics.. Pharmacological reports : PR, 64(3), 680-697. doi:10.1016/s1734-1140(12)70863-0

DOI
10.1016/s1734-1140(12)70863-0
Journal article

2011

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

Lister, A., Nedjadi, T., Kitteringham, N. R., Campbell, F., Costello, E., Lloyd, B., . . . Park, B. K. (2011). Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. Molecular Cancer, 10(1). doi:10.1186/1476-4598-10-37

DOI
10.1186/1476-4598-10-37
Journal article

Circulating MicroRNAs as Potential Markers of Human Drug-Induced Liver Injury

Lewis, P. J. S., Dear, J., Platt, V., Simpson, K. J., Craig, D. G. N., Antoine, D. J., . . . Park, B. K. (2011). Circulating MicroRNAs as Potential Markers of Human Drug-Induced Liver Injury. HEPATOLOGY, 54(5), 1767-1776. doi:10.1002/hep.24538

DOI
10.1002/hep.24538
Journal article

Tetracycline-inducible protein expression in pancreatic cancer cells: Effects of CapG overexpression

Tonack, S., Patel, S., Jalali, M., Nedjadi, T., Jenkins, R. E., Goldring, C., . . . Costello, E. (2011). Tetracycline-inducible protein expression in pancreatic cancer cells: Effects of CapG overexpression. WORLD JOURNAL OF GASTROENTEROLOGY, 17(15), 1947-1960. doi:10.3748/wjg.v17.i15.1947

DOI
10.3748/wjg.v17.i15.1947
Journal article

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

Lister, A., Nedjadi, T., Kitteringham, N. R., Campbell, F., Costello, E., Lloyd, B., . . . Park, B. K. (2011). Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. MOLECULAR CANCER, 10. doi:10.1186/1476-4598-10-37

DOI
10.1186/1476-4598-10-37
Journal article

Assessing the safety of stem cell therapeutics

Goldring, C., Duffy, P. A., Benvenisty, N., Andrews, P. W., Ben-David, U., Eakins, R., . . . Park, K. (2011). Assessing the safety of stem cell therapeutics. Cell Stem Cell, 8(6), 618-628.

Journal article

Assessing the safety of stem cell therapeutics.

Goldring, C., Duffy, P. A., Benvenisty, N., Andrews, P. W., Ben-David, U., Eakins, R., . . . Park, B. K. (2011). Assessing the safety of stem cell therapeutics.. Unknown Journal, 618-628.

Journal article

Managing the Challenge of Chemically Reactive Metabolites in Drug Development.

Park, B. K., Boobis, A., Clarke, S., Goldring, C., Jones, D., Kenna, G., . . . Baillie, T. A. (2011). Managing the Challenge of Chemically Reactive Metabolites in Drug Development.. Unknown Journal, 292-306.

Journal article

Managing the challenge of chemically reactive metabolites in drug development.

Park, B. K., Boobis, A., Clarke, S., Goldring, C., Jones, D., Kenna, J. G., . . . Baillie, T. A. (2011). Managing the challenge of chemically reactive metabolites in drug development.. Nature Reviews Drug Discovery, 10(4), 292-306.

Journal article

Novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3

Bone, T., & Goldring, C. (2011). Novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3. J. Cell Science, In press.

Journal article

Nrf2 is over-expressed in pancreatic cancer: implications for cell proliferation and therapy

Lister, A., Nedjadi, T., Kitteringham, N. R., Campbell, F., Costello, E., Lloyd, B., . . . Park, B. K. (2011). Nrf2 is over-expressed in pancreatic cancer: implications for cell proliferation and therapy. Molecular Cancer, 10, 37.

Journal article

miRNAs in biofluids as markers of human drug-induced liver injury

Starkey-Lewis, P. J., Dear, J., Platt, V., Simpson, K. J., Craig, D. G. N., Antoine, D. J., . . . Park, B. K. (2011). miRNAs in biofluids as markers of human drug-induced liver injury. Hepatology, In Press.

Journal article

2010

Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB

Chia, A. J. L., Goldring, C. E., Kitteringham, N. R., Wong, S. Q., Morgan, P., & Park, B. K. (2010). Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB. BIOCHEMICAL PHARMACOLOGY, 80(3), 410-421. doi:10.1016/j.bcp.2010.04.004

DOI
10.1016/j.bcp.2010.04.004
Journal article

Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening

Baxter, M. A., Rowe, C., Alder, J., Harrison, S., Hanley, K. P., Park, B. K., . . . Hanley, N. A. (2010). Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening. Stem Cell Research, 5(1), 4-22. doi:10.1016/j.scr.2010.02.002

DOI
10.1016/j.scr.2010.02.002
Journal article

Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening.

Baxter, M. A., Rowe, C., Alder, J., Harrison, S., Hanley, K. P., Park, B. K., . . . Hanley, N. A. (2010). Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening.. Stem cell research, 5(1), 4-22. doi:10.1016/j.scr.2010.02.002

DOI
10.1016/j.scr.2010.02.002
Journal article

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver

Kitteringham, N. R., Abdullah, A., Walsh, J., Randle, L., Jenkins, R. E., Sison, R., . . . Park, B. K. (2010). Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver. JOURNAL OF PROTEOMICS, 73(8), 1612-1631. doi:10.1016/j.jprot.2010.03.018

DOI
10.1016/j.jprot.2010.03.018
Journal article

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

Copple, I. M., Lister, A., Obeng, A. D., Kitteringham, N. R., Jenkins, R. E., Layfield, R., . . . Park, B. K. (2010). Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(22), 16782-16788. doi:10.1074/jbc.M109.096545

DOI
10.1074/jbc.M109.096545
Journal article

Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach.

Rowe, C., Goldring, C. E. P., Kitteringham, N. R., Jenkins, R. E., Lane, B. S., Sanderson, C., . . . Park, B. K. (2010). Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach.. Journal of proteome research, 9(5), 2658-2668. doi:10.1021/pr1001687

DOI
10.1021/pr1001687
Journal article

The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity.

Copple, I. M., Goldring, C. E., Kitteringham, N. R., & Park, B. K. (2010). The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity.. Handbook of experimental pharmacology, (196), 233-266. doi:10.1007/978-3-642-00663-0_9

DOI
10.1007/978-3-642-00663-0_9
Journal article

The Keap1-Nrf2 cellular defense pathway: Mechanisms of regulation and role in protection against drug-induced toxicity

Copple, I., Goldring, C., Kitteringham, N., & Park, K. (2010). The Keap1-Nrf2 cellular defense pathway: Mechanisms of regulation and role in protection against drug-induced toxicity. Handbook of Experimental Pharmacology, 196, 233-266.

Journal article

2009

Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1

Megherbi, R., Kiorpelidou, E., Foster, B., Rowe, C., Naisbitt, D. J., Goldring, C. E., & Park, B. K. (2009). Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1. Toxicology and Applied Pharmacology, 238(2), 120-132. doi:10.1016/j.taap.2009.05.001

DOI
10.1016/j.taap.2009.05.001
Journal article

Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1

Megherbi, R., Kiorpelidou, E., Foster, B., Rowe, C., Naisbitt, D. J., Goldring, C. E., & Park, B. K. (2009). Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1. TOXICOLOGY AND APPLIED PHARMACOLOGY, 238(2), 120-132. doi:10.1016/j.taap.2009.05.001

DOI
10.1016/j.taap.2009.05.001
Journal article

Extract of <i>Ginkgo biloba</i> induces glutathione-S-transferase subunit-P1 <i>in vitro</i>

Liu, X. -P., Goldring, C. E. P., Wang, H. -Y., Copple, I. M., Kitteringham, N. R., & Park, B. K. (2009). Extract of <i>Ginkgo biloba</i> induces glutathione-S-transferase subunit-P1 <i>in vitro</i>. PHYTOMEDICINE, 16(5), 451-455. doi:10.1016/j.phymed.2008.11.001

DOI
10.1016/j.phymed.2008.11.001
Journal article

An Investigation of the expression of cytochrome P450 3A7 and cytochrome P450 3A4 during stem cell differentiation for use as markers of emerging hepatic phenotype

Curley, P., Kelly, L., Shaw, R., Kitteringham, N., Jenkins, R., Alder, J., . . . Park, K. (2009). An Investigation of the expression of cytochrome P450 3A7 and cytochrome P450 3A4 during stem cell differentiation for use as markers of emerging hepatic phenotype. In British Pharmacology Society Winter Meeting. London, UK.

Conference Paper

Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells.

Ignatova, I. D., Kostadinova, R. M., Goldring, C. E., Nawrocki, A. R., Frey, F. J., & Frey, B. M. (2009). Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells.. Am J Physiol Endocrinol Metab.

Journal article

2008

The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system

Copple, I. M., Goldring, C. E., Jenkins, R. E., Chia, A. J. L., Randle, L. E., Hayes, J. D., . . . Park, B. K. (2008). The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system. HEPATOLOGY, 48(4), 1292-1301. doi:10.1002/hep.22472

DOI
10.1002/hep.22472
Journal article

The Nrf2-Keapl defence pathway: Role in protection against drug-induced toxicity

Copple, I. M., Goldring, C. E., Kitteringham, N. R., & Park, B. K. (2008). The Nrf2-Keapl defence pathway: Role in protection against drug-induced toxicity. TOXICOLOGY, 246(1), 24-33. doi:10.1016/j.tox.2007.10.029

DOI
10.1016/j.tox.2007.10.029
Journal article

Extract of <i>Ginkgo biloba</i> induces glutamate cysteine ligase catalytic subunit (GCLC)

Liu, X. -P., Goldring, C. E. P., Wang, H. -Y., Copple, I. M., Kitteringharn, N. R., Park, B. K., & Wei, W. (2008). Extract of <i>Ginkgo biloba</i> induces glutamate cysteine ligase catalytic subunit (GCLC). PHYTOTHERAPY RESEARCH, 22(3), 367-371. doi:10.1002/ptr.2328

DOI
10.1002/ptr.2328
Journal article

Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites.

Jenkins, R. E., Kitteringham, N. R., Goldring, C. E. P., Dowdall, S. M. J., Hamlett, J., Lane, C. S., . . . Park, B. K. (2008). Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites.. Proteomics, 8(2), 301-315. doi:10.1002/pmic.200700843

DOI
10.1002/pmic.200700843
Journal article

The Nrf2-Keap1 defence pathway: Role in protection against drug-induced toxicity

Copple, I., Goldring, C., Kitteringham, N., & Park, K. (2008). The Nrf2-Keap1 defence pathway: Role in protection against drug-induced toxicity. Toxicology, 246, 24-33.

Journal article

2007

Detection and biochemical characterisation of a novel polymorphism in the human <i>GSTP1</i> gene

Kitteringham, N. R., Palmer, L., Owen, A., Lian, L. -Y., Jenkins, R., Dowdall, S., . . . Goldring, C. E. (2007). Detection and biochemical characterisation of a novel polymorphism in the human <i>GSTP1</i> gene. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1770(8), 1240-1247. doi:10.1016/j.bbagen.2007.05.001

DOI
10.1016/j.bbagen.2007.05.001
Journal article

Extract of <i>Ginkgo biloba</i> induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway

Liu, X. -P., Goldring, C. E. P., Copple, I. M., Wang, H. -Y., Wei, W., Kitteringham, N. R., & Park, B. K. (2007). Extract of <i>Ginkgo biloba</i> induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway. LIFE SCIENCES, 80(17), 1586-1591. doi:10.1016/j.lfs.2007.01.034

DOI
10.1016/j.lfs.2007.01.034
Journal article

Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway

Liu, X. -P., Goldring, C. E. P., Copple, I. M., Wang, H. -Y., Wei, W., Kitteringham, N. R., & Park, B. K. (2007). Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway. Life Sciences, 80(17), 1586-1591. doi:10.1016/j.lfs.2007.01.034

DOI
10.1016/j.lfs.2007.01.034
Journal article

Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice.

Randle, L. E., Goldring, C., Benson, C. A., Metcalfe, P. N., Kitteringham, N. R., Park, B. K., & Williams, D. P. (2007). Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice.. Toxicology.

Journal article

2006

Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elements

Owen, A., Goldring, C., Morgan, P., Park, B. K., & Pirmohamed, M. (2006). Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elements. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 62(2), 237-242. doi:10.1111/j.1365-2125.2006.02587.x

DOI
10.1111/j.1365-2125.2006.02587.x
Journal article

Plasticity in cell defence: access to and reactivity of critical protein residues and DNA response elements

Goldring, C., Kitteringham, N., Jenkins, R., Copple, I., Jeannin, J. F., & Park, B. K. (2006). Plasticity in cell defence: access to and reactivity of critical protein residues and DNA response elements. JOURNAL OF EXPERIMENTAL BIOLOGY, 209(12), 2337-2343. doi:10.1242/jeb.02209

DOI
10.1242/jeb.02209
Journal article

Activation of the Nrf2/are antioxidant pathway by N-acetyl-p-benzoquinoneimine (NAPQI)

Copple, I. M., Goldring, C., Jenkins, R., Kitteringham, N., & Park, B. K. (2006). Activation of the Nrf2/are antioxidant pathway by N-acetyl-p-benzoquinoneimine (NAPQI). Drug Metabolism Reviews, 38, 49.

Journal article

Analysis of inter-individual variation in the Nrf2/Keap1 genes responsible for induction of the antioxidant response

Wang, H., Goldring, C., Kitteringham, N., & Park, B. K. (2006). Analysis of inter-individual variation in the Nrf2/Keap1 genes responsible for induction of the antioxidant response. Drug Metabolism Reviews, 38, 84-85.

Journal article

Chemical modification of glutathione S-transferase PI: A model for characterization of chemically reactive metabolites

Jenkins, R., Kitteringham, N., Goldring, C., Metcalfe, P., Dowdall, S., & Park, B. K. (2006). Chemical modification of glutathione S-transferase PI: A model for characterization of chemically reactive metabolites. Drug Metabolism Reviews, 38, 154-155.

Journal article

Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes

Goldring, C. E. P., Kitteringham, N. R., Jenkins, R., Lovatt, C. A., Randle, L. E., Abdullah, A., . . . Park, B. K. (2006). Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 290(1), C104-C115. doi:10.1152/ajpcell.00133.2005

DOI
10.1152/ajpcell.00133.2005
Journal article

Mechanisms of defence during chemical-induced hepatotoxicity

Randle, L. E., Williams, D. P., Goldring, C., & Park, B. K. (2006). Mechanisms of defence during chemical-induced hepatotoxicity. Drug Metabolism Reviews, 38, 56-58.

Journal article

Pharmacogenetic and functional analysis of a novel GSTP1 polymorphism

Palmer, L., Goldring, C., Kitteringham, N., Owen, A., Gilmore, I., & Park, K. (2006). Pharmacogenetic and functional analysis of a novel GSTP1 polymorphism. Drug Metabolism Reviews, 38, 91.

Journal article

Tetracycline-inducible pancreatic cancer cell lines

Patel, S. I., Bier, M., Goldring, C., Hillen, W., & Costello, E. (2006). Tetracycline-inducible pancreatic cancer cell lines. Pancreas, 33(4), 489.

Journal article

2005

Relationship between the C<sub>3435</sub>T and G<sub>2677</sub>T(A) polymorphisms in the <i>ABCB1</i> gene and P-glycoprotein expression in human liver

Owen, A., Goldring, C., Morgan, P., Chadwick, D., Park, B. K., & Pirmohamed, M. (2005). Relationship between the C<sub>3435</sub>T and G<sub>2677</sub>T(A) polymorphisms in the <i>ABCB1</i> gene and P-glycoprotein expression in human liver. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(3), 365-370. doi:10.1111/j.1365-2125.2005.02229.x

DOI
10.1111/j.1365-2125.2005.02229.x
Journal article

Interindividual variation in the expression of the cellular redox sensor Keap1 and its novel splice variants in human lymphocytes

Abdullah, A., Goldring, C., Owen, A., Kitteringham, N., & Park, K. (2005). Interindividual variation in the expression of the cellular redox sensor Keap1 and its novel splice variants in human lymphocytes. Toxicology, 213(3), 261-262.

Journal article

Proteomic analysis of liver protein expression in transgenic mice deficient in the transcription factor Nrf2

Kitteringham, N., Abdullah, A., Jenkins, R., Goldring, C., Hayes, J. D., & Park, K. (2005). Proteomic analysis of liver protein expression in transgenic mice deficient in the transcription factor Nrf2. Drug Metabolism Reviews, 37, 23.

Journal article

2004

Activation of hepatic Nrf2 <i>in vivo</i> by acetaminophen in CD-1 mice

Goldring, C. E. P., Kitteringham, N. R., Elsby, R., Randle, L. E., Clement, Y. N., Williams, D. P., . . . Park, B. K. (2004). Activation of hepatic Nrf2 <i>in vivo</i> by acetaminophen in CD-1 mice. HEPATOLOGY, 39(5), 1267-1276. doi:10.1002/hep.20183

DOI
10.1002/hep.20183
Journal article

2003

Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi.

Elsby, R., Kitteringham, N. R., Goldring, C. E., Lovatt, C. A., Chamberlain, M., Henderson, C. J., . . . Park, B. K. (2003). Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi.. The Journal of biological chemistry, 278(25), 22243-22249. doi:10.1074/jbc.m301211200

DOI
10.1074/jbc.m301211200
Journal article

2002

In vivo footprinting of the human 11beta-hydroxysteroid dehydrogenase type 2 promoter: evidence for cell-specific regulation by Sp1 and Sp3.

Nawrocki, A. R., Goldring, C. E., Kostadinova, R. M., Frey, F. J., & Frey, B. M. (2002). In vivo footprinting of the human 11beta-hydroxysteroid dehydrogenase type 2 promoter: evidence for cell-specific regulation by Sp1 and Sp3.. The Journal of biological chemistry, 277(17), 14647-14656. doi:10.1074/jbc.m111549200

DOI
10.1074/jbc.m111549200
Journal article

2000

Heat shock enhances transcriptional activation of the murine-inducible nitric oxide synthase gene.

Goldring, C. E., Reveneau, S., Chantome, A., Pance, A., Fleury, C., Hume, D. A., . . . Jeannin, J. F. (2000). Heat shock enhances transcriptional activation of the murine-inducible nitric oxide synthase gene.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 14(15), 2393-2395. doi:10.1096/fj.98-0509fje

DOI
10.1096/fj.98-0509fje
Journal article