Publications
Selected publications
- Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly (Journal article - 2020)
- An apical MRCK-driven morphogenetic pathway controls epithelial polarity (Journal article - 2017)
- Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation (Journal article - 2014)
- Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis (Journal article - 2011)
- Spatiotemporal control of actomyosin contractility by MRCKβ signaling drives phagocytosis (Journal article - 2022)
- A Gene Therapy Technology to Treat Retinal Disease (Patent - 2021)
2024
ZO-1 Regulates Hippo-Independent YAP Activity and Cell Proliferation via a GEF-H1- and TBK1-Regulated Signalling Network.
Haas, A. J., Karakus, M., Zihni, C., Balda, M. S., & Matter, K. (2024). ZO-1 Regulates Hippo-Independent YAP Activity and Cell Proliferation via a GEF-H1- and TBK1-Regulated Signalling Network.. Cells, 13(7), 640. doi:10.3390/cells13070640
2023
ZO-1 regulates Hippo-independent YAP activity and cell proliferation via a GEF-H1- and TBK1-regulated mechanosensitive signalling network
2022
ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions
Haas, A. J. J., Zihni, C., Krug, S. M. M., Maraspini, R., Otani, T., Furuse, M., . . . Matter, K. (2022). ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions. CELLS, 11(23). doi:10.3390/cells11233775
Spatiotemporal control of actomyosin contractility by MRCKβ signaling drives phagocytosis
Zihni, C., Georgiadis, A., Ramsden, C. M., Sanchez-Heras, E., Haas, A. J., Nommiste, B., . . . Matter, K. (2022). Spatiotemporal control of actomyosin contractility by MRCKβ signaling drives phagocytosis. JOURNAL OF CELL BIOLOGY, 221(11). doi:10.1083/jcb.202012042
Reciprocal regulation between cell mechanics and ZO-1 guides tight junction assembly and epithelial morphogenesis
2021
MRCK: a master regulator of tissue remodeling or another 'ROCK' in the epithelial block?
Zihni, C. (2021). MRCK: a master regulator of tissue remodeling or another 'ROCK' in the epithelial block?. TISSUE BARRIERS, 9(3). doi:10.1080/21688370.2021.1916380
Spatiotemporal Control of Actomyosin Contractility by MRCKβ Signaling Drives Phagocytosis
A Gene Therapy Technology to Treat Retinal Disease
Zihni, C., Matter, K., & Balda, M. (2021, February 2). US20230135501A1, A Gene Therapy Technology to Treat Retinal Disease. Worldwide.
2020
Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly
Haas, A. J., Zihni, C., Ruppel, A., Hartmann, C., Ebnet, K., Tada, M., . . . Matter, K. (2020). Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly. CELL REPORTS, 32(3). doi:10.1016/j.celrep.2020.107924
2018
An Imaging Protocol to Quantitate Microvilli Ultrastructure Induction by Epithelia.
Zihni, C., Zihni, C., S Balda, M., & Matter, K. (n.d.). An Imaging Protocol to Quantitate Microvilli Ultrastructure Induction by Epithelia.. Protocol Exchange. doi:10.1038/protex.2017.112
2017
An apical MRCK-driven morphogenetic pathway controls epithelial polarity
Zihni, C., Vlassaks, E., Terry, S., Carlton, J., Leung, T. K. C., Olson, M., . . . Matter, K. (2017). An apical MRCK-driven morphogenetic pathway controls epithelial polarity. NATURE CELL BIOLOGY, 19(9), 1049-+. doi:10.1038/ncb3592
Biallelic Mutation of <i>ARHGEF18</i>, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration
Arno, G., Carss, K. J., Hull, S., Zihni, C., Robson, A. G., Fiorentino, A., . . . Webster, A. R. (2017). Biallelic Mutation of <i>ARHGEF18</i>, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration. AMERICAN JOURNAL OF HUMAN GENETICS, 100(2), 334-342. doi:10.1016/j.ajhg.2016.12.014
2016
Tight junctions: from simple barriers to multifunctional molecular gates
Zihni, C., Mills, C., Matter, K., & Balda, M. S. (2016). Tight junctions: from simple barriers to multifunctional molecular gates. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 17(9), 564-580. doi:10.1038/nrm.2016.80
2015
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer
Zihni, C., & Terry, S. J. (2015). RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 64, 120-125. doi:10.1016/j.biocel.2015.02.020
2014
Signalling at tight junctions during epithelial differentiation and microbial pathogenesis
Zihni, C., Balda, M. S., & Matter, K. (2014). Signalling at tight junctions during epithelial differentiation and microbial pathogenesis. JOURNAL OF CELL SCIENCE, 127(16), 3401-3413. doi:10.1242/jcs.145029
MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival
Steed, E., Elbediwy, A., Vacca, B., Dupasquier, S., Hemkemeyer, S. A., Suddason, T., . . . Matter, K. (2014). MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival. JOURNAL OF CELL BIOLOGY, 204(5), 821-838. doi:10.1083/jcb.201304115
Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation
Zihni, C., Munro, P. M. G., Elbediwy, A., Keep, N. H., Terry, S. J., Harris, J., . . . Matter, K. (2014). Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation. JOURNAL OF CELL BIOLOGY, 204(1), 111-127. doi:10.1083/jcb.201304064
2012
Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex
Elbediwy, A., Zihni, C., Terry, S. J., Clark, P., Matter, K., & Balda, M. S. (2012). Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex. JOURNAL OF CELL BIOLOGY, 198(4), 677-693. doi:10.1083/jcb.201202094
Stimulation of Cortical Myosin Phosphorylation by p114RhoGEF Drives Cell Migration and Tumor Cell Invasion
Terry, S. J., Elbediwy, A., Zihni, C., Harris, A. R., Bailly, M., Charras, G. T., . . . Matter, K. (2012). Stimulation of Cortical Myosin Phosphorylation by p114RhoGEF Drives Cell Migration and Tumor Cell Invasion. PLOS ONE, 7(11). doi:10.1371/journal.pone.0050188
2011
Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis
Terry, S. J., Zihni, C., Elbediwy, A., Vitiello, E., San, I. V. L. C., Balda, M. S., & Matter, K. (2011). Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis. NATURE CELL BIOLOGY, 13(2), 159-U120. doi:10.1038/ncb2156