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Professor Catriona Waitt
BSc (Hons), MBChB (Hons), MRCP, DTM&H, PhD

Publications

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2024

Cost-Effectiveness of Dolutegravir Compared With Efavirenz for Prevention of Perinatal Transmission in Women Presenting With HIV in Late Pregnancy in Uganda.

Nuwamanya, E., Nassiwa, S. C., Kuznik, A., Waitt, C., Malaba, T., Myer, L., . . . Lamorde, M. (2024). Cost-Effectiveness of Dolutegravir Compared With Efavirenz for Prevention of Perinatal Transmission in Women Presenting With HIV in Late Pregnancy in Uganda.. Value in health regional issues, 44, 101017. doi:10.1016/j.vhri.2024.101017

DOI
10.1016/j.vhri.2024.101017
Journal article

Recruitment of pregnant and breastfeeding women in pharmacokinetic studies: strategies, opportunities, barriers, and recommendations.

Nakijoba, R., Kawuma, A. N., Asiimwe, S. P., Turyahabwe, C., Tabwenda, J. C., Kyeyune, J., . . . Waitt, C. (2024). Recruitment of pregnant and breastfeeding women in pharmacokinetic studies: strategies, opportunities, barriers, and recommendations.. BMC research notes, 17(1), 312. doi:10.1186/s13104-024-06946-x

DOI
10.1186/s13104-024-06946-x
Journal article

Interim analysis, a tool to enhance efficiency of pharmacokinetic studies: Pharmacokinetics of rifampicin in lactating mother–infant pairs

Kawuma, A. N., Ojara, F. W., Buzibye, A., Castelnuovo, B., Tabwenda, J. C., Kyeyune, J., . . . Waitt, C. (n.d.). Interim analysis, a tool to enhance efficiency of pharmacokinetic studies: Pharmacokinetics of rifampicin in lactating mother–infant pairs. CPT: Pharmacometrics & Systems Pharmacology. doi:10.1002/psp4.13247

DOI
10.1002/psp4.13247
Journal article

Addressing health equity for breastfeeding women: primaquine for Plasmodium vivax radical cure.

Abla, N., Marrast, A. C., Jambert, E., Richardson, N., Duparc, S., Almond, L., . . . El Gaaloul, M. (2024). Addressing health equity for breastfeeding women: primaquine for Plasmodium vivax radical cure.. Malaria journal, 23(1), 287. doi:10.1186/s12936-024-05112-9

DOI
10.1186/s12936-024-05112-9
Journal article

Evaluation of pharmacokinetics of Tenofovir Alafenamide (TAF) and Tenofovir Disoproxil (TDF) in pregnant and postpartum women in South Africa: PrEP-PP PK study.

Joseph Davey, D., Dadan, S., Bheemraj, K., Waitt, C., Khoo, S., Myer, L., . . . Orrell, C. (2024). Evaluation of pharmacokinetics of Tenofovir Alafenamide (TAF) and Tenofovir Disoproxil (TDF) in pregnant and postpartum women in South Africa: PrEP-PP PK study.. Antiviral research, 231, 106014. doi:10.1016/j.antiviral.2024.106014

DOI
10.1016/j.antiviral.2024.106014
Journal article

Clinical pharmacology considerations and drug-drug interactions with long-acting cabotegravir and rilpivirine relevant to sub-Saharan Africa.

Steulet, A., Obura, B., Waitt, C., Laker, E., Nicol, M. R., & Cresswell, F. V. (2024). Clinical pharmacology considerations and drug-drug interactions with long-acting cabotegravir and rilpivirine relevant to sub-Saharan Africa.. British journal of clinical pharmacology, 90(9), 2079-2091. doi:10.1111/bcp.16154

DOI
10.1111/bcp.16154
Journal article

Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study

Nakijoba, R., Nakayiwa Kawuma, A., Ojara, F. W., Tabwenda, J. C., Kyeyune, J., Turyamureba, C., . . . Waitt, C. (n.d.). Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study. Wellcome Open Research, 8, 216. doi:10.12688/wellcomeopenres.19113.4

DOI
10.12688/wellcomeopenres.19113.4
Journal article

Clinical, pharmacological, and qualitative characterization of drug-drug interactions in pregnant women initiating HIV therapy in Sub-Saharan Africa.

Kiiza, D., Rostami-Hochaghan, D., Alhassan, Y., Seden, K., Reynolds, H., Kaboggoza, J. P., . . . Lamorde, M. (2024). Clinical, pharmacological, and qualitative characterization of drug-drug interactions in pregnant women initiating HIV therapy in Sub-Saharan Africa.. The Journal of antimicrobial chemotherapy, dkae232. doi:10.1093/jac/dkae232

DOI
10.1093/jac/dkae232
Journal article

The role of community engagement in promoting research participants' understanding of pharmacogenomic research results: Perspectives of stakeholders involved in HIV/AIDS research and treatment.

Nabukenya, S., Kyaddondo, D., Munabi, I. G., Waitt, C., Twimukye, A., & Mwaka, E. S. (2024). The role of community engagement in promoting research participants' understanding of pharmacogenomic research results: Perspectives of stakeholders involved in HIV/AIDS research and treatment.. PloS one, 19(4), e0299081. doi:10.1371/journal.pone.0299081

DOI
10.1371/journal.pone.0299081
Journal article

‘<i>It is a complex process, but it’s very important to return these results to participants’</i>. Stakeholders’ perspectives on the ethical considerations for returning individual pharmacogenomics research results to people living with HIV

Nabukenya, S., Kyaddondo, D., Twimukye, A., Munabi, I. G., Waitt, C., & Mwaka, E. S. (2024). ‘<i>It is a complex process, but it’s very important to return these results to participants’</i>. Stakeholders’ perspectives on the ethical considerations for returning individual pharmacogenomics research results to people living with HIV. Research Ethics, 20(2), 363-387. doi:10.1177/17470161231207739

DOI
10.1177/17470161231207739
Journal article

Clinical Pharmacology considerations and drug-drug interactions with long-acting cabotegravir and rilpivirine relevant to a sub-Saharan Africa

DOI
10.22541/au.171136390.08597941/v1
Preprint

Comparison of dolutegravir- and efavirenz on depression, anxiety and sleep disorders in pregnant and postpartum women living with HIV; a DolPHIN2 substudy.

van der Wekken-Pas, L., Nassiwa, S., Malaba, T., Lamorde, M., Myer, L., Waitt, C., . . . Colbers, A. (2024). Comparison of dolutegravir- and efavirenz on depression, anxiety and sleep disorders in pregnant and postpartum women living with HIV; a DolPHIN2 substudy.. AIDS (London, England). doi:10.1097/qad.0000000000003852

DOI
10.1097/qad.0000000000003852
Journal article

Adapting citizens’ jury methodology for use in Uganda: use of creative arts as a tool in deliberative, participatory research

Waitt, C., Nakyeyune, L., Ashaba, A., Ahebwa, S., Nakijoba, R., Asiimwe, S. P., . . . Walker, L. E. (n.d.). Adapting citizens’ jury methodology for use in Uganda: use of creative arts as a tool in deliberative, participatory research. International Journal of Social Research Methodology, 1-10. doi:10.1080/13645579.2024.2396371

DOI
10.1080/13645579.2024.2396371
Journal article

Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study

DOI
10.12688/wellcomeopenres.19113.2
Preprint

Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study.

Nakijoba, R., Nakayiwa Kawuma, A., Ojara, F. W., Tabwenda, J. C., Kyeyune, J., Turyamureba, C., . . . Waitt, C. (2023). Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study.. Wellcome open research, 8, 216. doi:10.12688/wellcomeopenres.19113.3

DOI
10.12688/wellcomeopenres.19113.3
Journal article

2023

PA-727 Physiologically-based pharmacokinetic modelling of drug-drug interactions between ritonavir-boosted atazanavir and rifampicin in pregnancy

Atoyebi, S., Montanha, M. C., Najjemba, L., Orrell, C., Jennings, L., Mugerwa, H., . . . Waitt, C. (2023). PA-727 Physiologically-based pharmacokinetic modelling of drug-drug interactions between ritonavir-boosted atazanavir and rifampicin in pregnancy. In Abstracts of Poster and e-Poster Presentations (pp. A114.2-A114). BMJ Publishing Group Ltd. doi:10.1136/bmjgh-2023-edc.279

DOI
10.1136/bmjgh-2023-edc.279
Conference Paper

Research Participants' Preferences for Individual Results of Pharmacogenomics Research: A Case of a Ugandan HIV Research Institute

Nabukenya, S., Waitt, C., Senyonga, R., Castelnuovo, B., Munabi, I. G., Kyaddondo, D., & Mwaka, E. S. (2023). Research Participants' Preferences for Individual Results of Pharmacogenomics Research: A Case of a Ugandan HIV Research Institute. JOURNAL OF EMPIRICAL RESEARCH ON HUMAN RESEARCH ETHICS, 18(4), 218-232. doi:10.1177/15562646231187434

DOI
10.1177/15562646231187434
Journal article

-Pharmacokinetics of antimalarial drugs used to treat uncomplicated malaria in breastfeeding mother-infant pairs: An observational pharmacokinetic study.

Nakijoba, R., Nakayiwa Kawuma, A., Ojara, F. W., Tabwenda, J. C., Kyeyune, J., Turyahabwe, C., . . . Waitt, C. (2023). -Pharmacokinetics of antimalarial drugs used to treat uncomplicated malaria in breastfeeding mother-infant pairs: An observational pharmacokinetic study.. Wellcome open research, 8, 12. doi:10.12688/wellcomeopenres.18512.1

DOI
10.12688/wellcomeopenres.18512.1
Journal article

­Pharmacokinetics of antimalarial drugs used to treat uncomplicated malaria in breastfeeding mother-infant pairs: An observational pharmacokinetic study

Nakijoba, R., Nakayiwa Kawuma, A., Ojara, F. W., Tabwenda, J., Kyeyune, J., Turyahabwe, C., . . . Waitt, C. (2023). ­Pharmacokinetics of antimalarial drugs used to treat uncomplicated malaria in breastfeeding mother-infant pairs: An observational pharmacokinetic study. Wellcome Open Research. doi:10.12688/wellcomeopenres.18512.2

DOI
10.12688/wellcomeopenres.18512.2
Journal article

A commentary on establishing a local centre of excellence for research and training in pharmacometrics: Lessons from the pharmacometrics Africa-Uganda chapter

Najjemba, L., Kawuma, A. N., Ojara, F. W., Obura, B., Sekaggya-Wiltshire, C., Arinaitwe, W., . . . Waitt, C. (2023). A commentary on establishing a local centre of excellence for research and training in pharmacometrics: Lessons from the pharmacometrics Africa-Uganda chapter. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. doi:10.1111/bcp.15832

DOI
10.1111/bcp.15832
Journal article

Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study

Nakijoba, R., Nakayiwa Kawuma, A., Ojara, F. W., Tabwenda, J., Kyeyune, J., Turyamureba, C., . . . Waitt, C. (2023). Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study. Wellcome Open Research. doi:10.12688/wellcomeopenres.19113.1

DOI
10.12688/wellcomeopenres.19113.1
Journal article

Relating CYP2B6 Genotype and EFV Resistance Among Women Living With HIV With High Viremia in Uganda: A Nested Cross-Sectional Study.

BUZIBYE, A. L. L. A. N., Wools-Kaloustian, K., Olagunju, A., Twinomuhwezi, E., Yiannoutsos, C., Owen, A., . . . Kiragga, A. (2023). Relating CYP2B6 Genotype and EFV Resistance Among Women Living With HIV With High Viremia in Uganda: A Nested Cross-Sectional Study.. AIDS Research and Therapy. doi:10.1186/s12981-023-00514-2

DOI
10.1186/s12981-023-00514-2
Journal article

Relating CYP2B6 genotype and efavirenz resistance among post-partum women living with HIV with high viremia in Uganda: a nested cross-sectional study.

Buzibye, A., Wools-Kaloustian, K., Olagunju, A., Twinomuhwezi, E., Yiannoutsos, C., Owen, A., . . . Kiragga, A. (2023). Relating CYP2B6 genotype and efavirenz resistance among post-partum women living with HIV with high viremia in Uganda: a nested cross-sectional study.. AIDS research and therapy, 20(1), 20. doi:10.1186/s12981-023-00514-2

DOI
10.1186/s12981-023-00514-2
Journal article

A commentary on establishing a local centre of excellence for research and training in Pharmacometrics: Lessons from the Pharmacometrics Africa -Uganda Chapter.

DOI
10.22541/au.167816419.93514129/v1
Preprint

A "Bundle of Care" to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study

Jorgensen, A. L., Orrell, C., Waitt, C., Toh, C. -H., Sekaggya-Wiltshire, C., Hughes, D. A., . . . Pirmohamed, M. (2023). A "Bundle of Care" to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study. JMIR RESEARCH PROTOCOLS, 12. doi:10.2196/46710

DOI
10.2196/46710
Journal article

A “Bundle of Care” to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study (Preprint)

DOI
10.2196/preprints.46710
Preprint

Communication is crucial: Lessons from COVID-19 vaccination and pregnancy

Cole, C., Tsakiroglou, M., & Waitt, C. (2023). Communication is crucial: Lessons from COVID-19 vaccination and pregnancy. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 89(2), 582-593. doi:10.1111/bcp.15578

DOI
10.1111/bcp.15578
Journal article

Establishing a local centre of excellence for research and training in pharmacometrics: Lessons from the Pharmacometrics Africa -Uganda chapter

DOI
10.22541/au.167298128.83067335/v1
Preprint

­Pharmacokinetics of drugs used to treat uncomplicated malaria in breastfeeding mother-infant pairs: An observational pharmacokinetic study

Nakijoba, R., Nakayiwa Kawuma, A., Ojara, F. W., Tabwenda, J., Kyeyune, J., Turyahabwe, C., . . . Waitt, C. (2023). ­Pharmacokinetics of drugs used to treat uncomplicated malaria in breastfeeding mother-infant pairs: An observational pharmacokinetic study. Wellcome Open Research. doi:10.12688/wellcomeopenres.18512.1

DOI
10.12688/wellcomeopenres.18512.1
Journal article

It Takes A Village; Involvement of Village Health Teams to Develop Tools and Resources to Communicate about Antiretroviral Use in Pregnancy and Breastfeeding at Community Level in Uganda.

Nalugga, E. A., Kukundakwe, M., Tibakanya, R., Tindyebwa, E., Baluku, W., Mulindwa, K., . . . Waitt, C. (2023). It Takes A Village; Involvement of Village Health Teams to Develop Tools and Resources to Communicate about Antiretroviral Use in Pregnancy and Breastfeeding at Community Level in Uganda.. Wellcome open research, 8, 510. doi:10.12688/wellcomeopenres.19088.1

DOI
10.12688/wellcomeopenres.19088.1
Journal article

2022

Clinical trials and pregnancy.

Waitt, C., Astill, D., Zavala, E., Karron, R. A., Faden, R. R., Stratton, P., . . . Clayton, J. A. (2022). Clinical trials and pregnancy.. Communications medicine, 2, 132. doi:10.1038/s43856-022-00198-1

DOI
10.1038/s43856-022-00198-1
Journal article

Validation and application of a quantitative LC-MS/MS assay for the analysis of first-line anti-tuberculosis drugs, rifabutin and their metabolites in human breast milk

Zuma, P., Joubert, A., van der Merwe, M., Norman, J., Waitt, C., Court, R., . . . Wiesner, L. (2022). Validation and application of a quantitative LC-MS/MS assay for the analysis of first-line anti-tuberculosis drugs, rifabutin and their metabolites in human breast milk. Journal of Chromatography B, 1211, 123489. doi:10.1016/j.jchromb.2022.123489

DOI
10.1016/j.jchromb.2022.123489
Journal article

Predicting Drug-Drug Interactions between Rifampicin and Ritonavir-Boosted Atazanavir Using PBPK Modelling (vol 61, pg 375, 2022)

Montanha, M. C., Fabrega, F., Howarth, A., Cottura, N., Kinvig, H., Bunglawala, F., . . . Siccardi, M. (2022). Predicting Drug-Drug Interactions between Rifampicin and Ritonavir-Boosted Atazanavir Using PBPK Modelling (vol 61, pg 375, 2022). CLINICAL PHARMACOKINETICS, 61(11), 1641. doi:10.1007/s40262-022-01178-3

DOI
10.1007/s40262-022-01178-3
Journal article

A genome-wide association study of plasma concentrations of warfarin enantiomers and metabolites in sub-Saharan black-African patients.

Asiimwe, I. G., Blockman, M., Cohen, K., Cupido, C., Hutchinson, C., Jacobson, B., . . . Pirmohamed, M. (2022). A genome-wide association study of plasma concentrations of warfarin enantiomers and metabolites in sub-Saharan black-African patients.. Frontiers in pharmacology, 13, 967082. doi:10.3389/fphar.2022.967082

DOI
10.3389/fphar.2022.967082
Journal article

72 weeks post-partum follow-up of dolutegravir versus efavirenz initiated in late pregnancy (DolPHIN-2): an open-label, randomised controlled study

Malaba, T. R., Nakatudde, I., Kintu, K., Colbers, A., Chen, T., Reynolds, H., . . . Khoo, S. (2022). 72 weeks post-partum follow-up of dolutegravir versus efavirenz initiated in late pregnancy (DolPHIN-2): an open-label, randomised controlled study. LANCET HIV, 9(8), E534-E543. doi:10.1016/S2352-3018(22)00173-4

DOI
10.1016/S2352-3018(22)00173-4
Journal article

'I fear my partner will abandon me': the intersection of late initiation of antenatal care in pregnancy and poor ART adherence among women living with HIV in South Africa and Uganda

Alhassan, Y., Twimukye, A., Malaba, T., Myer, L., Waitt, C., Lamorde, M., . . . Taegtmeyer, M. (2022). 'I fear my partner will abandon me': the intersection of late initiation of antenatal care in pregnancy and poor ART adherence among women living with HIV in South Africa and Uganda. BMC PREGNANCY AND CHILDBIRTH, 22(1). doi:10.1186/s12884-022-04896-5

DOI
10.1186/s12884-022-04896-5
Journal article

<i>"It's only fatness, it doesn't kill"</i>: a qualitative study on perceptions of weight gain from use of dolutegravir-based regimens in women living with HIV in Uganda

Alhassan, Y., Twimukye, A., Malaba, T., Myer, L., Waitt, C., Lamorde, M., . . . Taegtmeyer, M. (2022). <i>"It's only fatness, it doesn't kill"</i>: a qualitative study on perceptions of weight gain from use of dolutegravir-based regimens in women living with HIV in Uganda. BMC WOMENS HEALTH, 22(1). doi:10.1186/s12905-022-01814-x

DOI
10.1186/s12905-022-01814-x
Journal article

A randomized comparison of health-related quality of life outcomes of dolutegravir versus efavirenz-based antiretroviral treatment initiated in the third trimester of pregnancy

Ochanda, P. N., Lamorde, M., Kintu, K., Wang, D., Chen, T., Malaba, T., . . . Khoo, S. (2022). A randomized comparison of health-related quality of life outcomes of dolutegravir versus efavirenz-based antiretroviral treatment initiated in the third trimester of pregnancy. AIDS RESEARCH AND THERAPY, 19(1). doi:10.1186/s12981-022-00446-3

DOI
10.1186/s12981-022-00446-3
Journal article

High willingness to use injectable antiretroviral therapy among women who have been lost to follow-up from HIV programmes: A nested cross-sectional study

Odongpiny, E. L. A., Cresswell, F., Arinaitwe, A., Nakate, V., Kyenkya, J., Lamorde, M., . . . Kiragga, A. (2022). High willingness to use injectable antiretroviral therapy among women who have been lost to follow-up from HIV programmes: A nested cross-sectional study. HIV MEDICINE, 23(4), 319-323. doi:10.1111/hiv.13260

DOI
10.1111/hiv.13260
Journal article

HIV viral load non-suppression and associated factors among pregnant and postpartum women in rural northeastern South Africa: a cross-sectional survey.

Ngandu, N. K., Lombard, C. J., Mbira, T. E., Puren, A., Waitt, C., Prendergast, A. J., . . . Goga, A. E. (2022). HIV viral load non-suppression and associated factors among pregnant and postpartum women in rural northeastern South Africa: a cross-sectional survey.. BMJ open, 12(3), e058347. doi:10.1136/bmjopen-2021-058347

DOI
10.1136/bmjopen-2021-058347
Journal article

PBPK MODELING OF LONG-ACTING INJECTABLE CABOTEGRAVIR IN PREGNANCY

Atoyebi, S., Bunglawala, F., Cottura, N., Camotti-Montanha, M., Siccardi, M., & Waitt, C. (2022). PBPK MODELING OF LONG-ACTING INJECTABLE CABOTEGRAVIR IN PREGNANCY. In Fazila Bunglawala. Conference on Retroviruses and Opportunistic Infections.

Conference Paper

Physiologically based pharmacokinetic modelling of long-acting rilpivirine in pregnancy

Atoyebi, S., Granana-Castillo, S., Siccardi, M., & Waitt, C. (2022). Physiologically based pharmacokinetic modelling of long-acting rilpivirine in pregnancy. In JOURNAL OF THE INTERNATIONAL AIDS SOCIETY Vol. 25 (pp. 186-187). Retrieved from https://www.webofscience.com/

Conference Paper

Stable warfarin dose prediction in sub-Saharan African patients: A machine-learning approach and external validation of a clinical dose-initiation algorithm

Asiimwe, I. G., Blockman, M., Cohen, K., Cupido, C., Hutchinson, C., Jacobson, B., . . . Pirmohamed, M. (2022). Stable warfarin dose prediction in sub-Saharan African patients: A machine-learning approach and external validation of a clinical dose-initiation algorithm. CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 11(1), 20-29. doi:10.1002/psp4.12740

DOI
10.1002/psp4.12740
Journal article

2021

An open-label, randomized, single intravenous dosing study to investigate the effect of fixed-dose combinations of tenofovir/lamivudine or atazanavir/ritonavir on the pharmacokinetics of remdesivir in Ugandan healthy volunteers (RemTLAR)

Walimbwa, S. I., Kaboggoza, J. P., Waitt, C., Byakika-Kibwika, P., D’Avolio, A., & Lamorde, M. (2021). An open-label, randomized, single intravenous dosing study to investigate the effect of fixed-dose combinations of tenofovir/lamivudine or atazanavir/ritonavir on the pharmacokinetics of remdesivir in Ugandan healthy volunteers (RemTLAR). Trials, 22(1). doi:10.1186/s13063-021-05752-1

DOI
10.1186/s13063-021-05752-1
Journal article

Developing and Validating a Clinical Warfarin Dose-Initiation Model for Black-African Patients in South Africa and Uganda (vol 109, pg 1564, 2021)

Asiimwe, I. G., Waitt, C., Sekaggya-Wiltshire, C., Hutchinson, C., Okello, E., Zhang, E. J., . . . Pirmohamed, M. (2021). Developing and Validating a Clinical Warfarin Dose-Initiation Model for Black-African Patients in South Africa and Uganda (vol 109, pg 1564, 2021). CLINICAL PHARMACOLOGY & THERAPEUTICS, 110(5), 1402. doi:10.1002/cpt.2395

DOI
10.1002/cpt.2395
Journal article

An open-label, randomized, single intravenous dosing study to investigate the effect of fixed dose combinations of tenofovir/lamivudine or atazanavir/ritonavir on the pharmacokinetics of remdesivir in Ugandan healthy volunteers (RemTLAR)

DOI
10.21203/rs.3.rs-377098/v1
Preprint

Advancing knowledge in perinatal HIV treatment.

Waitt, C., Myer, L., & Khoo, S. (2021). Advancing knowledge in perinatal HIV treatment.. The lancet. HIV, 8(3), e124-e125. doi:10.1016/s2352-3018(20)30306-4

DOI
10.1016/s2352-3018(20)30306-4
Journal article

2020

Onsite Mentorship Model for Isolation and Management of Viral Hemorrhagic Fever Syndromes at a Ugandan Hospital

Waitt, P., Nakato, S., Ayebare, R., Ssekabira, U., Nanyondo, J., Waitt, C., . . . Lamorde, M. (2020). Onsite Mentorship Model for Isolation and Management of Viral Hemorrhagic Fever Syndromes at a Ugandan Hospital. In INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY Vol. 41 (pp. S491-S492). doi:10.1017/ice.2020.1167

DOI
10.1017/ice.2020.1167
Conference Paper

Engendering health systems in response to national rollout of dolutegravir-based regimens among women of childbearing potential: a qualitative study with stakeholders in South Africa and Uganda

Alhassan, Y., Twimukye, A., Malaba, T., Orrell, C., Myer, L., Waitt, C., . . . Taegtmeyer, M. (2020). Engendering health systems in response to national rollout of dolutegravir-based regimens among women of childbearing potential: a qualitative study with stakeholders in South Africa and Uganda. BMC HEALTH SERVICES RESEARCH, 20(1). doi:10.1186/s12913-020-05580-0

DOI
10.1186/s12913-020-05580-0
Journal article

Development and validation of a UHPLC-MS/MS method for quantification of the prodrug remdesivir and its metabolite GS-441524: a tool for clinical pharmacokinetics of SARS-CoV-2/COVID-19 and Ebola virus disease

Avataneo, V., de Nicolò, A., Cusato, J., Antonucci, M., Manca, A., Palermiti, A., . . . D’Avolio, A. (2020). Development and validation of a UHPLC-MS/MS method for quantification of the prodrug remdesivir and its metabolite GS-441524: a tool for clinical pharmacokinetics of SARS-CoV-2/COVID-19 and Ebola virus disease. Journal of Antimicrobial Chemotherapy. doi:10.1093/jac/dkaa152

DOI
10.1093/jac/dkaa152
Journal article

COMPARATIVE QUALITY OF LIFE OUTCOMES OF DOLUTEGRAVIR-BASED OR EFAVIRENZ-BASED ANTIRETOVIRAL TREATMENT IN PREGNANCY FOR LATE PRESENTORS BETWEEN THE 3RD TRIAL-MESTER AND 48 WEEKS POSTPARTUM

Perez Nicholas, O., Lamorde, M., Kintu, K., Wang, D., Chen, T., Malaba, T., . . . Khoo, S. (2020). COMPARATIVE QUALITY OF LIFE OUTCOMES OF DOLUTEGRAVIR-BASED OR EFAVIRENZ-BASED ANTIRETOVIRAL TREATMENT IN PREGNANCY FOR LATE PRESENTORS BETWEEN THE 3RD TRIAL-MESTER AND 48 WEEKS POSTPARTUM. In VALUE IN HEALTH Vol. 23 (pp. S184). Retrieved from https://www.webofscience.com/

Conference Paper

PIN90 COMPARATIVE QUALITY OF LIFE OUTCOMES OF DOLUTEGRAVIR-BASED OR EFAVIRENZ-BASED ANTIRETOVIRAL TREATMENT IN PREGNANCY FOR LATE PRESENTORS BETWEEN THE 3RD TRIAL-MESTER AND 48 WEEKS POSTPARTUM

Perez Nicholas, O., Lamorde, M., Kintu, K., Wang, D., Chen, T., Malaba, T., . . . Khoo, S. (2020). PIN90 COMPARATIVE QUALITY OF LIFE OUTCOMES OF DOLUTEGRAVIR-BASED OR EFAVIRENZ-BASED ANTIRETOVIRAL TREATMENT IN PREGNANCY FOR LATE PRESENTORS BETWEEN THE 3RD TRIAL-MESTER AND 48 WEEKS POSTPARTUM. Value in Health, 23, S184. doi:10.1016/j.jval.2020.04.553

DOI
10.1016/j.jval.2020.04.553
Journal article

2019

Pharmacokinetics, Placental and Breastmilk Transfer of Antiretroviral Drugs in Pregnant and Lactating Women Living with HIV.

Hodel, E. M., Marzolini, C., Waitt, C., & Rakhmanina, N. (2019). Pharmacokinetics, Placental and Breastmilk Transfer of Antiretroviral Drugs in Pregnant and Lactating Women Living with HIV.. Current Pharmaceutical Design. doi:10.2174/1381612825666190320162507

DOI
10.2174/1381612825666190320162507
Journal article

2018

Validation and clinical application of a novel LC-MS method for quantification of dolutegravir in breast milk

Gini, J., Penchala, S. D., Amara, A., Challenger, E., Egan, D., Waitt, C., . . . Else, L. J. (2018). Validation and clinical application of a novel LC-MS method for quantification of dolutegravir in breast milk. BIOANALYSIS, 10(23), 1933-1945. doi:10.4155/bio-2018-0085

DOI
10.4155/bio-2018-0085
Journal article

DolPHIN-1: Randomised controlled trial of dolutegravir (DTG)- versus efavirenz (EFV)-based therapy in mothers initiating antiretroviral treatment in late pregnancy

Orrell, C., Kintu, K., Coombs, J. A., Amara, A., Myer, L., Kaboggoza, J., . . . Lamorde, M. (2018). DolPHIN-1: Randomised controlled trial of dolutegravir (DTG)- versus efavirenz (EFV)-based therapy in mothers initiating antiretroviral treatment in late pregnancy. In JOURNAL OF THE INTERNATIONAL AIDS SOCIETY Vol. 21 (pp. 166). Retrieved from https://www.webofscience.com/

Conference Paper

Drug Interactions Between Dolutegravir and Artemether-Lumefantrine or Artesunate-Amodiaquine

Walimbwa, S., Lamorde, M., Waitt, C., Kaboggoza, J., Else, L., Byakika-Kibwika, P., . . . Khoo, S. (2018). Drug Interactions Between Dolutegravir and Artemether-Lumefantrine or Artesunate-Amodiaquine. doi:10.1101/351684

DOI
10.1101/351684
Journal article

Plasma and breast milk pharmacokinetics of emtricitabine, tenofovir and lamivudine using dried blood and breast milk spots in nursing African mother-infant pairs.

Waitt, C., Olagunju, A., Nakalema, S., Kyohaire, I., Owen, A., Lamorde, M., & Khoo, S. (2018). Plasma and Breast Milk Pharmacokinetics of Emtricitabine, Tenofovir and Lamivudine Using Dried Blood and Breast Milk Spots in Nursing African Mother-Infant Pairs. Journal of Antimicrobial Chemotherapy, 73(4), 1013-1019. doi:10.1093/jac/dkx507

DOI
10.1093/jac/dkx507
Journal article

2017

Development, validation and clinical application of a method for the simultaneous quantification of lamivudine, emtricitabine and tenofovir in dried blood and dried breast milk spots using LC-MS/MS

Waitt, C., Penchala, S. D., Olagunju, A., Amara, A., Else, L., Lamorde, M., & Khoo, S. (2017). Development, validation and clinical application of a method for the simultaneous quantification of lamivudine, emtricitabine and tenofovir in dried blood and dried breast milk spots using LC-MS/MS. Journal of Chromatography B, 1060, 300-307. doi:10.1016/j.jchromb.2017.06.012

DOI
10.1016/j.jchromb.2017.06.012
Journal article

2016

2015

Monocyte unresponsiveness and impaired IL1β, TNFα and IL7 production are associated with a poor outcome in Malawian adults with pulmonary tuberculosis

Waitt, C. J., Banda, P., Glennie, S., Kampmann, B., Squire, S. B., Pirmohamed, M., & Heyderman, R. S. (2015). Monocyte unresponsiveness and impaired IL1β, TNFα and IL7 production are associated with a poor outcome in Malawian adults with pulmonary tuberculosis. BMC Infectious Diseases, 15. doi:10.1186/s12879-015-1274-4

DOI
10.1186/s12879-015-1274-4
Journal article

Validation and clinical application of a method to quantify nevirapine in dried blood spots and dried breast-milk spots

Olagunju, A., Amara, A., Waitt, C., Else, L., Penchala, S. D., Bolaji, O., . . . Khoo, S. (2015). Validation and clinical application of a method to quantify nevirapine in dried blood spots and dried breast-milk spots. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 70(10), 2816-2822. doi:10.1093/jac/dkv174

DOI
10.1093/jac/dkv174
Journal article

Breast Milk Pharmacokinetics of Efavirenz and Breastfed Infants' Exposure in Genetically Defined Subgroups of Mother-Infant Pairs: An Observational Study

Olagunju, A., Bolaji, O., Amara, A., Waitt, C., Else, L., Adejuyigbe, E., . . . Owen, A. (2015). Breast Milk Pharmacokinetics of Efavirenz and Breastfed Infants' Exposure in Genetically Defined Subgroups of Mother-Infant Pairs: An Observational Study. Clin Infect Dis, 61(3), 453-463. doi:10.1093/cid/civ317

DOI
10.1093/cid/civ317
Journal article

Is infant exposure to antiretroviral drugs during breastfeeding quantitatively important? A systematic review and meta-analysis of pharmacokinetic studies

Waitt, C. J., Garner, P., Bonnett, L. J., Khoo, S. H., & Else, L. J. (2015). Is infant exposure to antiretroviral drugs during breastfeeding quantitatively important? A systematic review and meta-analysis of pharmacokinetic studies. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 70(7), 1928-1941. doi:10.1093/jac/dkv080

DOI
10.1093/jac/dkv080
Journal article

Development, validation and clinical application of a novel method for the quantification of efavirenz in dried breast milk spots using LC-MS/MS

Olagunju, A., Bolaji, O. O., Amara, A., Waitt, C., Else, L., Soyinka, J., . . . Khoo, S. (2015). Development, validation and clinical application of a novel method for the quantification of efavirenz in dried breast milk spots using LC-MS/MS. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 70(2), 555-561. doi:10.1093/jac/dku420

DOI
10.1093/jac/dku420
Journal article

Development, validation and clinical application of a novel method for the quantification of efavirenz in dried breast milk spots using LC-MS/MS.

Olagunju, A., Bolaji, O. O., Amara, A., Waitt, C., Else, L., Soyinka, J., . . . Khoo, S. (2015). Development, validation and clinical application of a novel method for the quantification of efavirenz in dried breast milk spots using LC-MS/MS.. The Journal of antimicrobial chemotherapy, 70(2), 555-561.

Journal article

2014

Sepsis carries a high mortality among hospitalised adults in Malawi in the era of antiretroviral therapy scale-up: A longitudinal cohort study

Waitt, P. I., Mukaka, M., Goodson, P., SimuKonda, F. D., Waitt, C. J., Feasey, N., . . . Heyderman, R. S. (2014). Sepsis carries a high mortality among hospitalised adults in Malawi in the era of antiretroviral therapy scale-up: A longitudinal cohort study. Journal of Infection, 70(1), 11-19. doi:10.1016/j.jinf.2014.07.004

DOI
10.1016/j.jinf.2014.07.004
Journal article

2013

The effect of a tuberculosis chest X-ray image reference set on non-expert reader performance

Waitt, C. J., Joekes, E. C., Jesudason, N., Waitt, P. I., Goodson, P., Likumbo, G., . . . Squire, S. B. (2013). The effect of a tuberculosis chest X-ray image reference set on non-expert reader performance. EUROPEAN RADIOLOGY, 23(9), 2459-2468. doi:10.1007/s00330-013-2840-z

DOI
10.1007/s00330-013-2840-z
Journal article

2011

Early Deaths During Tuberculosis Treatment Are Associated With Depressed Innate Responses, Bacterial Infection, and Tuberculosis Progression

Waitt, C. J., Banda, N. P. K., White, S. A., Kampmann, B., Kumwenda, J., Heyderman, R. S., . . . Squire, S. B. (2011). Early Deaths During Tuberculosis Treatment Are Associated With Depressed Innate Responses, Bacterial Infection, and Tuberculosis Progression. JOURNAL OF INFECTIOUS DISEASES, 204(3), 358-362. doi:10.1093/infdis/jir265

DOI
10.1093/infdis/jir265
Journal article

A systematic review of risk factors for death in adults during and after tuberculosis treatment

Waitt, C. J., & Squire, S. B. (2011). A systematic review of risk factors for death in adults during and after tuberculosis treatment. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 15(7), 871-885. doi:10.5588/ijtld.10.0352

DOI
10.5588/ijtld.10.0352
Journal article

2008

Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes

Jones, S. P., Waitt, C., Sutton, R., Back, D. J., & Pirmohamed, M. (2008). Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes. AIDS, 22(11), 1293-1298. doi:10.1097/QAD.0b013e3283021a4f

DOI
10.1097/QAD.0b013e3283021a4f
Journal article

Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes

Jones, S. P., Waitt, C., Sutton, R., Back, D. J., & Pirmohamed, M. (2008). Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes. AIDS, 22(11), 1293-1298. doi:10.1097/qad.0b013e3283021a4f

DOI
10.1097/qad.0b013e3283021a4f
Journal article

2007

A rapid and sensitive HPLC-MS method for the detection of plasma and cellular rifampicin

Hartkoorn, R. C., Khoo, S., Back, D. J., Tjia, J. F., Waitt, C. J., Chaponda, M., . . . Ward, S. A. (2007). A rapid and sensitive HPLC-MS method for the detection of plasma and cellular rifampicin. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 857(1), 76-82. doi:10.1016/j.jchromb.2007.07.005

DOI
10.1016/j.jchromb.2007.07.005
Journal article

2005

A retained intravascular medical device and <i>Streptococcus bovis</i> infection, providing early diagnosis of an occult malignancy

Beadsworth, M., Waitt, C., Jenkins, N., Amadi, A., Nye, F., & Beeching, N. (2005). A retained intravascular medical device and <i>Streptococcus bovis</i> infection, providing early diagnosis of an occult malignancy. JOURNAL OF INFECTION, 50(2), 165-167. doi:10.1016/j.jinf.2004.08.024

DOI
10.1016/j.jinf.2004.08.024
Journal article

2004

Intravenous therapy

Waitt, C., Waitt, P., & Pirmohamed, M. (2004). Intravenous therapy. POSTGRADUATE MEDICAL JOURNAL, 80(939), 1-6. doi:10.1136/pmj.2003.010421

DOI
10.1136/pmj.2003.010421
Journal article