Publications
2024
Cappable-Seq reveals the transcriptional landscape of stress responses in the bacterial endosymbiont<i>Wolbachia</i>
SARS-CoV-2 population dynamics in immunocompetent individuals in a closed transmission chain shows genomic diversity over the course of infection.
Goldswain, H., Penrice-Randal, R., Donovan-Banfield, I., Duffy, C. W., Dong, X., Randle, N., . . . Emmett, S. R. (2024). SARS-CoV-2 population dynamics in immunocompetent individuals in a closed transmission chain shows genomic diversity over the course of infection.. Genome medicine, 16(1), 89. doi:10.1186/s13073-024-01360-1
Establishment and partial characterisation of a new cell line derived from adult tissues of the tsetse fly Glossina morsitans morsitans.
Bell-Sakyi, L., Haines, L. R., Petrucci, G., Beliavskaia, A., Hartley, C., Khoo, J. J., . . . Darby, A. C. (2024). Establishment and partial characterisation of a new cell line derived from adult tissues of the tsetse fly Glossina morsitans morsitans.. Parasites & vectors, 17(1), 231. doi:10.1186/s13071-024-06310-9
2023
The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.
Goldswain, H., Dong, X., Penrice-Randal, R., Alruwaili, M., Shawli, G. T., Prince, T., . . . Hiscox, J. A. (2023). The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.. Genome biology, 24(1), 47. doi:10.1186/s13059-023-02881-5
2022
Antibody response of heterologous vs homologous mRNA vaccine boosters against the SARS-CoV-2 Omicron variant: interim results from the PRIBIVAC study, A Randomized Clinical Trial
Poh, X. Y., Tan, C. W., Lee, I. R., Chavatte, J. -M., Fong, S. -W., Prince, T., . . . Young, B. E. (n.d.). Antibody response of heterologous vs homologous mRNA vaccine boosters against the SARS-CoV-2 Omicron variant: interim results from the PRIBIVAC study, A Randomized Clinical Trial. Clinical Infectious Diseases. doi:10.1093/cid/ciac345
New Cell Lines Derived from Laboratory Colony Triatoma infestans and Rhodnius prolixus, Vectors of Trypanosoma cruzi, Do Not Harbour Triatoma Virus
Penrice-Randal, R., Hartley, C., Beliavskaia, A., Dong, X., Brandner-Garrod, L., Whitten, M., & Bell-Sakyi, L. (2022). New Cell Lines Derived from Laboratory Colony Triatoma infestans and Rhodnius prolixus, Vectors of Trypanosoma cruzi, Do Not Harbour Triatoma Virus. INSECTS, 13(10). doi:10.3390/insects13100906
Blood gene expression predicts intensive care unit admission in hospitalised patients with COVID-19.
Penrice-Randal, R., Dong, X., Shapanis, A. G., Gardner, A., Harding, N., Legebeke, J., . . . Baralle, D. (2022). Blood gene expression predicts intensive care unit admission in hospitalised patients with COVID-19.. Frontiers in immunology, 13, 988685. doi:10.3389/fimmu.2022.988685
RIPpore: A Novel Host-Derived Method for the Identification of Ricin Intoxication through Oxford Nanopore Direct RNA Sequencing
Ryan, Y., Harrison, A., Trivett, H., Hartley, C., David, J., Clark, G. C., & Hiscox, J. A. (2022). RIPpore: A Novel Host-Derived Method for the Identification of Ricin Intoxication through Oxford Nanopore Direct RNA Sequencing. TOXINS, 14(7). doi:10.3390/toxins14070470
Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages
Prince, T., Dong, X., Penrice-Randal, R., Randle, N., Hartley, C., Goldswain, H., . . . Hiscox, J. A. (2022). Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages. MSPHERE, 7(3). doi:10.1128/msphere.00913-21
Co-Administration of Adjuvanted Recombinant <i>Ov</i>-103 and <i>Ov</i>-RAL-2 Vaccines Confer Protection against Natural Challenge in A Bovine <i>Onchocerca ochengi</i> Infection Model of Human Onchocerciasis
Luu, L., Bah, G. S., Okah-Nnane, N. H., Hartley, C. S., Glover, A. F., Walsh, T. R., . . . Graham-Brown, J. (2022). Co-Administration of Adjuvanted Recombinant <i>Ov</i>-103 and <i>Ov</i>-RAL-2 Vaccines Confer Protection against Natural Challenge in A Bovine <i>Onchocerca ochengi</i> Infection Model of Human Onchocerciasis. VACCINES, 10(6). doi:10.3390/vaccines10060861
New Cell Lines Derived from European Tick Species
Bell-Sakyi, L., Hartley, C. S., Khoo, J. J., Forth, J. H., Palomar, A. M., & Makepeace, B. L. (2022). New Cell Lines Derived from European Tick Species. MICROORGANISMS, 10(6). doi:10.3390/microorganisms10061086
Evaluating the Immune Response in Treatment-Naive Hospitalised Patients With Influenza and COVID-19
Legebeke, J., Lord, J., Penrice-Randal, R., Vallejo, A. F., Poole, S., Brendish, N. J., . . . Baralle, D. (2022). Evaluating the Immune Response in Treatment-Naive Hospitalised Patients With Influenza and COVID-19. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.853265
2021
Antiviral activity of Molnupiravir precursor NHC against SARS-CoV-2 Variants of Concern (VOCs) and implications for the therapeutic window and resistance
Resistance of SARS-CoV-2 variants to neutralization by convalescent plasma from early COVID-19 outbreak in Singapore
Wang, B., Goh, Y. S., Prince, T., Ngoh, E. Z. X., Salleh, S. N. M., Hor, P. X., . . . Wang, C. -I. (2021). Resistance of SARS-CoV-2 variants to neutralization by convalescent plasma from early COVID-19 outbreak in Singapore. NPJ VACCINES, 6(1). doi:10.1038/s41541-021-00389-2
Isolation in Natural Host Cell Lines of Wolbachia Strains wPip from the Mosquito Culex pipiens and wPap from the Sand Fly Phlebotomus papatasi
Bell-Sakyi, L., Beliavskaia, A., Hartley, C. S., Jones, L., Luu, L., Haines, L. R., . . . Makepeace, B. L. (2021). Isolation in Natural Host Cell Lines of Wolbachia Strains wPip from the Mosquito Culex pipiens and wPap from the Sand Fly Phlebotomus papatasi. INSECTS, 12(10). doi:10.3390/insects12100871
Using Oxford Nanopore Technology direct RNA sequencing to identify depurination events induced by ricin and other ribosome inactivating proteins
Tissue-Specific Immunopathology in Fatal COVID-19
Dorward, D. A., Russell, C. D., Um, I. H., Elshani, M., Armstrong, S. D., Penrice-Randal, R., . . . Lucas, C. D. (2021). Tissue-Specific Immunopathology in Fatal COVID-19. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 203(2), 192-201. doi:10.1164/rccm.202008-3265OC
CAPPABLE-SEQ REVEALS PROLIFIC NON-CANONICAL TRANSCRIPTION START SITES IN WOLBACHIA STRAINS WMELPOP-CLA AND WALBB UNDER STRESS CONDITIONS
Suliman, Y., Li, Z., Sinha, A., Dyer, P. D., Hartley, C. S., Ettwiller, L., . . . Makepeace, B. L. (2021). CAPPABLE-SEQ REVEALS PROLIFIC NON-CANONICAL TRANSCRIPTION START SITES IN WOLBACHIA STRAINS WMELPOP-CLA AND WALBB UNDER STRESS CONDITIONS. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 105 (pp. 153). Retrieved from https://www.webofscience.com/
2020
Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism
Moore, S. C., Penrice-Randal, R., Alruwaili, M., Randle, N., Armstrong, S., Hartley, C., . . . Hiscox, J. A. (2020). Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism. VIRUSES-BASEL, 12(10). doi:10.3390/v12101164
Tissue-specific tolerance in fatal Covid-19
Dorward, D., Russell, C., Um, I. H., Elshani, M., Armstrong, S., Penrice-Randal, R., . . . Lucas, C. (2020). Tissue-specific tolerance in fatal Covid-19. doi:10.1101/2020.07.02.20145003
Isolation and Propagation of Laboratory Strains and a Novel Flea-Derived Field Strain of <i>Wolbachia</i> in Tick Cell Lines.
Khoo, J. J., Kurtti, T. J., Husin, N. A., Beliavskaia, A., Lim, F. S., Zulkifli, M. M. S., . . . Bell-Sakyi, L. (2020). Isolation and Propagation of Laboratory Strains and a Novel Flea-Derived Field Strain of <i>Wolbachia</i> in Tick Cell Lines.. Microorganisms, 8(7), E988. doi:10.3390/microorganisms8070988
Isolation and Propagation of Laboratory Strains and a Novel Flea-Derived Field Strain of Wolbachia in Tick Cell Lines
Khoo, J. J., Kurtti, T., Husin, N. A., Beliavskaia, A., Lim, F. S., Zulkifli, M. M. S., . . . Bell-Sakyi, L. (2020). Isolation and Propagation of Laboratory Strains and a Novel Flea-Derived Field Strain of Wolbachia in Tick Cell Lines. Microorganisms, 8(7). doi:10.3390/microorganisms8070988
2019
The Tick Cell Biobank: new arthropod cell lines for arbovirus research
Bell-Sakyi, L., Hartley, C., Darby, A., Baylis, M., & Makepeace, B. (2019). The Tick Cell Biobank: new arthropod cell lines for arbovirus research. Access Microbiology, 1(10). doi:10.1099/acmi.imav2019.po0045
An Open-Format Enteroid Culture System for Interrogation of Interactions Between Toxoplasma gondii and the Intestinal Epithelium
Luu, L., Johnston, L. J., Derricott, H., Armstrong, S. D., Randle, N., Hartley, C. S., . . . Coombes, J. L. (2019). An Open-Format Enteroid Culture System for Interrogation of Interactions Between Toxoplasma gondii and the Intestinal Epithelium. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 9. doi:10.3389/fcimb.2019.00300
Aquatic Hemiptera in Southwest Cameroon: Biodiversity of Potential Reservoirs of <em>Mycobacterium ulcerans</em> and Multiple <em>Wolbachia</em> Sequence Types Revealed by Metagenomics
Developing a 3D intestinal epithelium model for livestock species
Derricott, H., Luu, L., Fong, W. Y., Hartley, C. S., Johnston, L. J., Armstrong, S. D., . . . Coombes, J. L. (2019). Developing a 3D intestinal epithelium model for livestock species. Cell and Tissue Research, 375(02), 409-424. doi:10.1007/s00441-018-2924-9
Assessing the performance of a Fasciola gigantica serum antibody ELISA to estimate prevalence in cattle in Cameroon.
Kelly, R. F., Mazeri, S., Hartley, C., Hamman, S. M., Ngu Ngwa, V., Nkongho, E. F., . . . Williams, D. J. L. (2019). Assessing the performance of a Fasciola gigantica serum antibody ELISA to estimate prevalence in cattle in Cameroon.. BMC veterinary research, 15(1), 8. doi:10.1186/s12917-018-1762-z
<i>AMBLYOMMA VARIEGATUM</i>, VECTOR OF AFRICAN TICK-BITE FEVER, CONTAINS AN INTEGRATED <i>RICKETTSIA AFRICAE</i> CHROMOSOME IN ITS NUCLEAR GENOME
Darby, A. C., Al-Khafaji, A. M., Whitehead, M., Hartley, C. S., Robinson, G., Armstrong, S. D., . . . Makepeace, B. (2019). <i>AMBLYOMMA VARIEGATUM</i>, VECTOR OF AFRICAN TICK-BITE FEVER, CONTAINS AN INTEGRATED <i>RICKETTSIA AFRICAE</i> CHROMOSOME IN ITS NUCLEAR GENOME. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 101 (pp. 211). Retrieved from https://www.webofscience.com/
Aquatic Hemiptera in Southwest Cameroon: Biodiversity of Potential Reservoirs of <i>Mycobacterium ulcerans</i> and Multiple <i>Wolbachia</i> Sequence Types Revealed by Metagenomics
Esemu, S. N., Dong, X., Kfusi, A. J., Hartley, C. S., Ndip, R. N., Ndip, L. M., . . . Makepeace, B. L. (2019). Aquatic Hemiptera in Southwest Cameroon: Biodiversity of Potential Reservoirs of <i>Mycobacterium ulcerans</i> and Multiple <i>Wolbachia</i> Sequence Types Revealed by Metagenomics. DIVERSITY-BASEL, 11(12). doi:10.3390/d11120225
2018
Bovine Neonatal Monocytes Display Phenotypic Differences Compared With Adults After Challenge With the Infectious Abortifacient Agent <i>Neospora caninum</i>
Sharma, P., Hartley, C. S., Haque, M., Coffey, T. J., Egan, S. A., & Flynn, R. J. (2018). Bovine Neonatal Monocytes Display Phenotypic Differences Compared With Adults After Challenge With the Infectious Abortifacient Agent <i>Neospora caninum</i>. FRONTIERS IN IMMUNOLOGY, 9. doi:10.3389/fimmu.2018.03011
Clonal amplification of Fasciola hepatica in Galba truncatula: within and between isolate variation of triclabendazole-susceptible and -resistant clones
Hodgkinson, J. E., Cwiklinski, K., Beesley, N., Hartley, C., Allen, K., & Williams, D. (2018). Clonal amplification of Fasciola hepatica in Galba truncatula: within and between isolate variation of triclabendazole-susceptible and -resistant clones. Parasites and Vectors, 11, 9 pages. doi:10.1186/s13071-018-2952-z
Erratum for Graham-Brown et al., “Dairy Heifers Naturally Exposed to Fasciola hepatica Develop a Type 2 Immune Response and Concomitant Suppression of Leukocyte Proliferation”
Graham-Brown, J., Hartley, C., Clough, H., Kadioglu, A., Baylis, M., & Williams, D. J. L. (2018). Erratum for Graham-Brown et al., “Dairy Heifers Naturally Exposed to Fasciola hepatica Develop a Type 2 Immune Response and Concomitant Suppression of Leukocyte Proliferation”. Infection and Immunity, 86(6). doi:10.1128/IAI.00247-18
Dairy heifers naturally exposed to Fasciola hepatica develop a type-2 immune response and concomitant suppression of leukocyte proliferation.
Graham-Brown, J., Hartley, C., Clough, H., Kadioglu, A., Baylis, M., & Williams, D. J. L. (2018). Dairy heifers naturally exposed to Fasciola hepatica develop a type-2 immune response and concomitant suppression of leukocyte proliferation.. Infection and Immunity, 86(1). doi:10.1128/iai.00607-17
2017
Prevalence of Giardia infection in households of Giardia cases and risk factors for household transmission
Waldram, A., Vivancos, R., Hartley, C., & Lamden, K. (2017). Prevalence of Giardia infection in households of Giardia cases and risk factors for household transmission. BMC INFECTIOUS DISEASES, 17. doi:10.1186/s12879-017-2586-3
2016
Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism
Jackson, A. P., Otto, T. D., Aslett, M., Armstrong, S. D., Bringaud, F., Schlacht, A., . . . Berriman, M. (2016). Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism. Current Biology, 26(2), 161-172. doi:10.1016/j.cub.2015.11.055
2014
Integrated transcriptomic and proteomic analysis of the global response of <i>Wolbachia</i> to doxycycline-induced stress
Darby, A. C., Gill, A. C., Armstrong, S. D., Hartley, C. S., Xia, D., Wastling, J. M., & Makepeace, B. L. (2014). Integrated transcriptomic and proteomic analysis of the global response of <i>Wolbachia</i> to doxycycline-induced stress. ISME JOURNAL, 8(4), 925-937. doi:10.1038/ismej.2013.192
2013
Transcriptome analysis of a parasitic clade V nematode: Comparative analysis of potential molecular anthelmintic targets in <i>Cylicostephanus goldi</i>
Cwiklinski, K., Merga, J. Y., Lake, S. L., Hartley, C., Matthews, J. B., Paterson, S., & Hodgkinson, J. E. (2013). Transcriptome analysis of a parasitic clade V nematode: Comparative analysis of potential molecular anthelmintic targets in <i>Cylicostephanus goldi</i>. INTERNATIONAL JOURNAL FOR PARASITOLOGY, 43(11), 917-927. doi:10.1016/j.ijpara.2013.06.010
Transcriptome analysis of a parasitic clade V nematode: comparative analysis of potential molecular anthelmintic targets in Cylicostephanus goldi.
Cwiklinski, K., Merga, J. Y., Lake, S. L., Hartley, C., Matthews, J. B., Paterson, S., & Hodgkinson, J. E. (2013). Transcriptome analysis of a parasitic clade V nematode: comparative analysis of potential molecular anthelmintic targets in Cylicostephanus goldi.. International journal for parasitology, 43(11), 917-927. doi:10.1016/j.ijpara.2013.06.010
EQUINE MULTINODULAR PULMONARY FIBROSIS: THE ROLE OF EHV-5 IN THE PATHOGENESIS OF AN EMERGING DISEASE
Leeming, G., Kipar, A., Hartley, C., Malbon, A., Hetzel, U., & Stewart, J. P. (2013). EQUINE MULTINODULAR PULMONARY FIBROSIS: THE ROLE OF EHV-5 IN THE PATHOGENESIS OF AN EMERGING DISEASE. In JOURNAL OF COMPARATIVE PATHOLOGY Vol. 148 (pp. 74). doi:10.1016/j.jcpa.2012.11.114
2012
Antimicrobial susceptibility testing of bovine digital dermatitis treponemes identifies macrolides for <i>in vivo</i> efficacy testing
Evans, N. J., Brown, J. M., Hartley, C., Smith, R. F., & Carter, S. D. (2012). Antimicrobial susceptibility testing of bovine digital dermatitis treponemes identifies macrolides for <i>in vivo</i> efficacy testing. VETERINARY MICROBIOLOGY, 160(3-4), 496-500. doi:10.1016/j.vetmic.2012.06.001
2011
Up Regulation of the Maternal Immune Response in the Placenta of Cattle Naturally Infected with <i>Neospora caninum</i>
Rosbottom, A., Gibney, H., Kaiser, P., Hartley, C., Smith, R. F., Robinson, R., . . . Williams, D. J. L. (2011). Up Regulation of the Maternal Immune Response in the Placenta of Cattle Naturally Infected with <i>Neospora caninum</i>. PLOS ONE, 6(1). doi:10.1371/journal.pone.0015799
'Up regulation of the maternal immune response in the placenta of cattle naturally infected with Neospora caninum'
Rosbottom, A., Gibney, H., Kaiser, P., Hartley, C., Smith, R. F., Robinson, R., . . . Williams, D. J. (2011). 'Up regulation of the maternal immune response in the placenta of cattle naturally infected with Neospora caninum'. PLoSOne, 6(1), e15799.
2009
Endogenous and exogenous transplacental transmission of Neospora caninum - how the route of transmission impacts on epidemiology and control of disease.
Williams, D. J. L., Hartley, C. S., Björkman, C., & Trees, A. J. (2009). Endogenous and exogenous transplacental transmission of Neospora caninum - how the route of transmission impacts on epidemiology and control of disease.. Parasitology, 136(14), 1895-1900. doi:10.1017/s0031182009990588
2008
Upregulation of cytokines is detected in the placentas of cattle infected with <i>Neospora caninum</i> and is more marked early in gestation when fetal death is observed
Rosbottom, A., Gibney, E. H., Guy, C. S., Kipar, A., Smith, R. F., Kaiser, P., . . . Williams, D. J. L. (2008). Upregulation of cytokines is detected in the placentas of cattle infected with <i>Neospora caninum</i> and is more marked early in gestation when fetal death is observed. INFECTION AND IMMUNITY, 76(6), 2352-2361. doi:10.1128/IAI.01780-06
2007
Peripheral immune responses in pregnant cattle following <i>Neospora caninum</i> infection
Rosbottom, A., Guy, C. S., Gibney, E. H., Smith, R. F., Valarcher, J. F., Taylor, G., & Williams, D. J. L. (2007). Peripheral immune responses in pregnant cattle following <i>Neospora caninum</i> infection. PARASITE IMMUNOLOGY, 29(4), 219-228. doi:10.1111/j.1365-3024.2007.00936.x
Immunization of cattle with live tachyzoites of <i>Neospora caninum</i> confers protection against fetal death
Williams, D. J. L., Guy, C. S., Smith, R. F., Ellis, J., Bjorkman, C., Reichel, M. P., & Trees, A. J. (2007). Immunization of cattle with live tachyzoites of <i>Neospora caninum</i> confers protection against fetal death. INFECTION AND IMMUNITY, 75(3), 1343-1348. doi:10.1128/IAI.00777-06