Publications
Selected publications
- A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide (Journal article - 2013)
- Progastrin-Induced Secretion of Insulin-Like Growth Factor 2 From Colonic Myofibroblasts Stimulates Colonic Epithelial Proliferation in Mice (Journal article - 2013)
- Suppression of Apoptosis, Crypt Hyperplasia, and Altered Differentiation in the Colonic Epithelia of <i>Bak</i>-Null Mice (Journal article - 2009)
- NF-kappaB1, NF-kappaB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice (Journal article - 2015)
- Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury (Journal article - 2017)
2024
Contact X-ray Brachytherapy as a sole treatment in selected patients with early rectal cancer – Multi-centre study
Wah Than, N., Mark Pritchard, D., Hughes, D. M., Shing Yu, K., Minnaar, H. S., Dhadda, A., . . . Sun Myint, A. (2024). Contact X-ray Brachytherapy as a sole treatment in selected patients with early rectal cancer – Multi-centre study. Clinical and Translational Radiation Oncology, 100851. doi:10.1016/j.ctro.2024.100851
Sequence of Contact X-ray Brachytherapy (CXB) and External Beam Radiation (EBRT) in organ-preserving treatment for small rectal cancer
Than, N. W., Pritchard, D. M., Hughes, D. M., Duckworth, C. A., Wong, H., Ul Haq, M., . . . Myint, A. S. (2024). Sequence of Contact X-ray Brachytherapy (CXB) and External Beam Radiation (EBRT) in organ-preserving treatment for small rectal cancer. Radiotherapy and Oncology, 110465. doi:10.1016/j.radonc.2024.110465
Timing of Contact X-ray Brachytherapy in organ-preserving treatment of rectal cancer
Than, N., Pritchard, D. M., Duckworth, C. A., Hughes, D. M., & Myint, A. S. (2024). Timing of Contact X-ray Brachytherapy in organ-preserving treatment of rectal cancer. In ESTRO 2024 Vol. 194 Supplement 1 (pp. 186-189). Glasgow, UK: Journal of the European Society for Raidotherapy and Oncology. Retrieved from https://user-swndwmf.cld.bz/ESTRO-2024-Abstract-Book/186/
Contact X-ray brachytherapy (CXB) as a salvage treatment for rectal cancer patients who developed local tumor re-growth after watch-and-wait approach.
Than, N. W., Pritchard, D. M., Duckworth, C. A., Hughes, D. M., Wong, H., Sripadam, R., & Myint, A. S. (2024). Contact X-ray brachytherapy (CXB) as a salvage treatment for rectal cancer patients who developed local tumor re-growth after watch-and-wait approach.. Journal of contemporary brachytherapy, 16(2), 95-102. doi:10.5114/jcb.2024.139049
2023
Homeostasis, injury, and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt.
Gall, L., Duckworth, C., Jardi, F., Lammens, L., Parker, A., Bianco, A., . . . Pin, C. (2023). Homeostasis, injury, and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt.. eLife, 12, e85478. doi:10.7554/elife.85478
A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug-induced toxicity.
Gall, L., Jardi, F., Lammens, L., Piñero, J., Souza, T. M., Rodrigues, D., . . . Pin, C. (2023). A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug-induced toxicity.. CPT: pharmacometrics & systems pharmacology. doi:10.1002/psp4.13029
C1GalT1 expression reciprocally controls tumour cell-cell and tumour-macrophage interactions mediated by galectin-3 and MGL with double impact on cancer development and progression.
Wan, Y., Adair, K., Herrmann, A., Shan, X., Xia, L., Duckworth, C. A., & Yu, L. -G. (2023). C1GalT1 expression reciprocally controls tumour cell-cell and tumour-macrophage interactions mediated by galectin-3 and MGL with double impact on cancer development and progression.. Cell death & disease, 14(8), 547. doi:10.1038/s41419-023-06082-7
A novel <i>in vitro</i> model of the small intestinal epithelium in co-culture with 'gut-like' dendritic cells.
Johnston, L. J., Barningham, L., Campbell, E. L., Cerovic, V., Duckworth, C. A., Luu, L., . . . Coombes, J. L. (2023). A novel <i>in vitro</i> model of the small intestinal epithelium in co-culture with 'gut-like' dendritic cells.. Discovery immunology, 2(1), kyad018. doi:10.1093/discim/kyad018
Mouse organoids as an in vitro tool to study the in vivo intestinal response to cytotoxicants
Jardi, F., Kelly, C., Teague, C., Fowler-Williams, H., Sevin, D. C., Rodrigues, D., . . . Pritchard, D. M. (2023). Mouse organoids as an in vitro tool to study the in vivo intestinal response to cytotoxicants. ARCHIVES OF TOXICOLOGY, 97(1), 235-254. doi:10.1007/s00204-022-03374-3
2022
Galectin-2 in Health and Diseases
Negedu, M. N., Duckworth, C. A., & Yu, L. -G. (2023). Galectin-2 in Health and Diseases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(1). doi:10.3390/ijms24010341
Homeostasis, injury and recovery dynamics at multiple scales in a self-organizing intestinal crypt
Manipulating the composition of the culture medium promotes neuroendocrine cell differentiation in mouse and human gastric organoids
Exarchou, K., Duckworth, C., Stephens, N., Howes, N., & Mark, P. D. (n.d.). Manipulating the composition of the culture medium promotes neuroendocrine cell differentiation in mouse and human gastric organoids. Endocrine Abstracts. doi:10.1530/endoabs.87.p3
Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa
Papoutsopoulou, S., Tang, J., Elramli, A. H., Williams, J. M., Gupta, N., Ikuomola, F. I., . . . Pritchard, D. M. (2022). Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa. American Journal of Physiology: Gastrointestinal and Liver Physiology, 323(4), G306-G317. doi:10.1152/ajpgi.00037.2022
Interleukin-10 Deficiency Impacts on TNF-Induced NFκB Regulated Responses In Vivo.
Papoutsopoulou, S., Pollock, L., Williams, J. M., Abdul-Mahdi, M. M. L. F., Dobbash, R., Duckworth, C. A., & Campbell, B. J. (2022). Interleukin-10 Deficiency Impacts on TNF-Induced NFκB Regulated Responses In Vivo.. Biology, 11(10), 1377. doi:10.3390/biology11101377
THE IMPACT OF ALTERNATIVE (NON-CANONICAL) NF-κB PATHWAY INHIBITION IN PREVENTING INTESTINAL BARRIER DYSFUNCTION IN IBD
Tang, J., Papoutsopoulou, S., Mackay, S., Paul, A., Duckworth, C., & Pritchard, M. (2022). THE IMPACT OF ALTERNATIVE (NON-CANONICAL) NF-κB PATHWAY INHIBITION IN PREVENTING INTESTINAL BARRIER DYSFUNCTION IN IBD. In GUT Vol. 71 (pp. A140). doi:10.1136/gutjnl-2022-BSG.258
2021
Soluble Non-Starch Polysaccharides From Plantain (<i>Musa x paradisiaca</i> L.) Diminish Epithelial Impact of <i>Clostridioides difficile</i>
Simpson, H. L., Roberts, C. L., Thompson, L. M., Leiper, C. R., Gittens, N., Trotter, E., . . . Campbell, B. J. (2021). Soluble Non-Starch Polysaccharides From Plantain (<i>Musa x paradisiaca</i> L.) Diminish Epithelial Impact of <i>Clostridioides difficile</i>. FRONTIERS IN PHARMACOLOGY, 12. doi:10.3389/fphar.2021.766293
Identifying key regulators of the intestinal stem cell niche
Duckworth, C. A. (2021). Identifying key regulators of the intestinal stem cell niche. BIOCHEMICAL SOCIETY TRANSACTIONS, 49(5), 2163-2176. doi:10.1042/BST20210223
Appearance of peanut agglutinin in the blood circulation after peanut ingestion promotes endothelial secretion of metastasis-promoting cytokines
Wang, W., Sindrewicz-Goral, P., Chen, C., Duckworth, C. A., Pritchard, D. M., Rhodes, J. M., & Yu, L. -G. (2021). Appearance of peanut agglutinin in the blood circulation after peanut ingestion promotes endothelial secretion of metastasis-promoting cytokines. CARCINOGENESIS, 42(8), 1079-1088. doi:10.1093/carcin/bgab059
A "Watch and Wait" Strategy Involving Regular Endoscopic Surveillance Is Safe for Many Patients with Small, Sporadic, Grade 1, Non-Ampullary, Non-Functioning Duodenal Neuroendocrine Tumours
Exarchou, K., Moore, A. R., Smart, H. L., Duckworth, C. A., Howes, N., & Pritchard, D. M. (2021). A "Watch and Wait" Strategy Involving Regular Endoscopic Surveillance Is Safe for Many Patients with Small, Sporadic, Grade 1, Non-Ampullary, Non-Functioning Duodenal Neuroendocrine Tumours. NEUROENDOCRINOLOGY, 111(8), 764-774. doi:10.1159/000511613
Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification
Howell, L., Jenkins, R. E., Lynch, S., Duckworth, C., Kevin Park, B., & Goldring, C. (2021). Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification. ARCHIVES OF TOXICOLOGY, 95(7), 2413-2430. doi:10.1007/s00204-021-03075-3
IP1867B suppresses the Insulin-like Growth Factor 1 Receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas (Retraction of Vol 458, Pg 29, 2019)
Mihajluk, K., Simms, C., Reay, M., Madureira, P. A., Howarth, A., Murray, P., . . . Hill, R. (2021). IP1867B suppresses the Insulin-like Growth Factor 1 Receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas (Retraction of Vol 458, Pg 29, 2019). CANCER LETTERS, 507, 39. doi:10.1016/j.canlet.2021.03.008
Dilodendron bipinnatum Radlk. extract alleviates ulcerative colitis induced by TNBS in rats by reducing inflammatory cell infiltration, TNF-α and IL-1β concentrations, IL-17 and COX-2 expressions, supporting mucus production and promotes an antioxidant effect.
Oliveira, R. G. D., Damazo, A. S., Antonielli, L. F., Miyajima, F., Pavan, E., Duckworth, C. A., . . . Martins, D. T. D. O. (2021). Dilodendron bipinnatum Radlk. extract alleviates ulcerative colitis induced by TNBS in rats by reducing inflammatory cell infiltration, TNF-α and IL-1β concentrations, IL-17 and COX-2 expressions, supporting mucus production and promotes an antioxidant effect.. Journal of Ethnopharmacology, 269, 113735. doi:10.1016/j.jep.2020.113735
Canthin-6-one ameliorates TNBS-induced colitis in rats by modulating inflammation and oxidative stress. An in vivo and in silico approach
Arunachalam, K., Damazo, A. S., Macho, A., Matchado, M. S., Pavan, E., Figueiredo, F. D. F., . . . de Oliveira Martins, D. T. (2021). Canthin-6-one ameliorates TNBS-induced colitis in rats by modulating inflammation and oxidative stress. An in vivo and in silico approach. BIOCHEMICAL PHARMACOLOGY, 186. doi:10.1016/j.bcp.2021.114490
Long-Term Iron Deficiency and Dietary Iron Excess Exacerbate Acute Dextran Sodium Sulphate-Induced Colitis and Are Associated with Significant Dysbiosis
Mahalhal, A., Burkitt, M. D., Duckworth, C. A., Hold, G. L., Campbell, B. J., Pritchard, D. M., & Probert, C. S. (2021). Long-Term Iron Deficiency and Dietary Iron Excess Exacerbate Acute Dextran Sodium Sulphate-Induced Colitis and Are Associated with Significant Dysbiosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(7). doi:10.3390/ijms22073646
IKKα AS A POTENTIAL THERAPEUTIC TARGET FOR THE PREVENTION OF INFLAMMATORY BOWEL DISEASE
Tang, J., Papoutsopoulou, S., Paul, A., MacKay, P. S., Duckworth, C., & Pritchard, M. (2021). IKKα AS A POTENTIAL THERAPEUTIC TARGET FOR THE PREVENTION OF INFLAMMATORY BOWEL DISEASE. In GUT Vol. 70 (pp. A126-A127). doi:10.1136/gutjnl-2020-bsgcampus.236
IRINOTECAN INDUCES A RAPID INCREASE IN ENTEROID PERMEABILITY
Turnbull, J. L., Lynch, S., Pritchard, D. M., Goldring, C. E. P., & Duckworth, C. A. (2021). IRINOTECAN INDUCES A RAPID INCREASE IN ENTEROID PERMEABILITY. In GUT Vol. 70 (pp. A177-A178). doi:10.1136/gutjnl-2020-bsgcampus.337
2020
Canthin-6-one ameliorates TNBS-induced colitis in rats by modulating inflammation and oxidative stress. An in vivo and in silico approach
Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease
Lloyd, K., Papoutsopoulou, S., Smith, E., Stegmaier, P., Bergey, F., Morris, L., . . . Burkitt, M. D. (2020). Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease. DISEASE MODELS & MECHANISMS, 13(11). doi:10.1242/dmm.044040
IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas (vol 458C, pg 29, 2019)
Mihajluk, K., Simms, C., Reay, M., Madureira, P. A., Howarth, A., Murray, P., . . . Hill, R. (2020). IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas (vol 458C, pg 29, 2019). CANCER LETTERS, 469, 524-525. doi:10.1016/j.canlet.2019.10.002
Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors
Lloyd, K. A., Parsons, B. N., Burkitt, M. D., Moore, A. R., Papoutsopoulou, S., Boyce, M., . . . Pritchard, D. M. (2020). Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors. CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 10(1), 113-132. doi:10.1016/j.jcmgh.2020.01.010
2019
Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research
Evans, J. P., Winiarski, B. K., Sutton, P. A., Ressel, L., Duckworth, C. A., Pritchard, D. M., . . . Kitteringham, N. R. (2019). Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research. LABORATORY ANIMALS, 53(6), 598-609. doi:10.1177/0023677219826165
NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells
Jones, L. G., Vaida, A., Thompson, L. M., Ikuomola, F. I., Caamaño, J. H., Burkitt, M. D., . . . Duckworth, C. A. (2019). NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells. Cell Death and Disease, 10. doi:10.1038/s41419-019-2129-5
An Open-Format Enteroid Culture System for Interrogation of Interactions Between Toxoplasma gondii and the Intestinal Epithelium
Luu, L., Johnston, L. J., Derricott, H., Armstrong, S. D., Randle, N., Hartley, C. S., . . . Coombes, J. L. (2019). An Open-Format Enteroid Culture System for Interrogation of Interactions Between Toxoplasma gondii and the Intestinal Epithelium. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 9. doi:10.3389/fcimb.2019.00300
IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas
Duckworth, C. A., Pritchard, D. M., Mihailuk, K., Simms, C., Reay, M., Madureira, P., . . . Hill, R. (2019). IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas. Cancer Letters. doi:10.1016/j.canlet.2019.05.028
DNA extraction and amplicon production strategies deeply influence the outcome of gut mycobiome studies
Frau, A., Kenny, J. G., Lenzi, L., Campbell, B. J., Ijaz, U. Z., Duckworth, C. A., . . . Probert, C. S. J. (2019). DNA extraction and amplicon production strategies deeply influence the outcome of gut mycobiome studies. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-44974-x
Replication of Crohn's Disease Mucosal E. coli Isolates inside Macrophages Correlates with Resistance to Superoxide and Is Dependent on Macrophage NF-kappa B Activation
Tawfik, A., Knight, P., Duckworth, C. A., Pritchard, D. M., Rhodes, J. M., & Campbell, B. J. (2019). Replication of Crohn's Disease Mucosal E. coli Isolates inside Macrophages Correlates with Resistance to Superoxide and Is Dependent on Macrophage NF-kappa B Activation. PATHOGENS, 8(2). doi:10.3390/pathogens8020074
Mice lacking NF-kappa B1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration (vol 8, e2939, 2017)
Burkitt, M. D., Williams, J. M., Townsend, T., Hough, R., Duckworth, C. A., & Pritchard, D. M. (2019). Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration (vol 8, e2939, 2017). CELL DEATH & DISEASE, 10. doi:10.1038/s41419-019-1534-0
Stem cell models as an <i>in vitro</i> model for predictive toxicology
Lynch, S., Pridgeon, C. S., Duckworth, C. A., Sharma, P., Park, B. K., & Goldring, C. E. P. (2019). Stem cell models as an <i>in vitro</i> model for predictive toxicology. BIOCHEMICAL JOURNAL, 476, 1149-1158. doi:10.1042/BCJ20170780
Long-term iron deficiency and iron supplementation exacerbate acute DSS-induced colitis and are associated with significant dysbiosis
Mahalhal, A., Burkitt, M., Duckworth, C., Hold, G., Campbell, B., Pritchard, M., & Probert, C. (2019). Long-term iron deficiency and iron supplementation exacerbate acute DSS-induced colitis and are associated with significant dysbiosis. doi:10.1101/585174
Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice
Reade, S., Williams, J. M., Aggio, R., Duckworth, C. A., Mahalhal, A., Hough, R., . . . Probert, C. S. (2019). Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice. FASEB JOURNAL, 33(3), 3129-3136. doi:10.1096/fj.201800076RR
Developing a 3D intestinal epithelium model for livestock species
Derricott, H., Luu, L., Fong, W. Y., Hartley, C. S., Johnston, L. J., Armstrong, S. D., . . . Coombes, J. L. (2019). Developing a 3D intestinal epithelium model for livestock species. Cell and Tissue Research, 375(02), 409-424. doi:10.1007/s00441-018-2924-9
Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.
Evans, J. P., Winiarski, B. K., Sutton, P. A., Jones, R. P., Ressel, L., Duckworth, C. A., . . . Kitteringham, N. R. (2019). Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.. Oncotarget, 10(6), 685. doi:10.18632/oncotarget.26625
Using systems medicine to identify a therapeutic agent with potential for repurposing in Inflammatory Bowel Disease
Endoscopic Surveillance Is a Viable Alternative Management Strategy for Patients with Localised Small Non-Functional Low Grade Duodenal Neuroendocrine Tumours (dNETs)
Exarchou, K., Howes, N., Moore, A., Duckworth, C. A., & Pritchard, D. M. (2019). Endoscopic Surveillance Is a Viable Alternative Management Strategy for Patients with Localised Small Non-Functional Low Grade Duodenal Neuroendocrine Tumours (dNETs). In NEUROENDOCRINOLOGY Vol. 108 (pp. 56). Retrieved from https://www.webofscience.com/
Endoscopic surveillance is a viable alternative management strategy for patients with localised small non-functional low grade duodenal neuroendocrine tumours (dNETs)
Exarchou, K., Howes, N., Moore, A., Duckworth, C. A., & Pritchard, D. M. (2019). Endoscopic surveillance is a viable alternative management strategy for patients with localised small non-functional low grade duodenal neuroendocrine tumours (dNETs). In BRITISH JOURNAL OF SURGERY Vol. 106 (pp. 74). Retrieved from https://www.webofscience.com/
Periodic endoscopic surveillance in patients with low risk Type 1 gastric neuroendocrine tumours (gNETs) also detects associated gastric adenocarcinoma in a subset of patients
Exarchou, K., Howes, N., Moore, A., Duckworth, C., & Pritchard, D. M. (2019). Periodic endoscopic surveillance in patients with low risk Type 1 gastric neuroendocrine tumours (gNETs) also detects associated gastric adenocarcinoma in a subset of patients. In BRITISH JOURNAL OF SURGERY Vol. 106 (pp. 85). Retrieved from https://www.webofscience.com/
2018
Oral iron exacerbates colitis and influences the intestinal microbiome
Mahalhal, A., Williams, J. M., Johnson, S., Ellaby, N., Duckworth, C. A., Burkitt, M. D., . . . Probert, C. S. (2018). Oral iron exacerbates colitis and influences the intestinal microbiome. PLOS ONE, 13(10). doi:10.1371/journal.pone.0202460
Oral iron exacerbates colitis and influences the intestinal microbiome
Mahalhal, A., Williams, J., Johnson, S., Ellaby, N., Duckworth, C., Burkitt, M., . . . Probert, C. (2018). Oral iron exacerbates colitis and influences the intestinal microbiome. doi:10.1101/385997
The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer
Evans, J. P., Winiarski, B. K., Sutton, P. A., Jones, R. P., Ressel, L., Duckworth, C. A., . . . Kitteringham, N. R. (2018). The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer. Oncotarget, 9(43), 27104-27116. doi:10.18632/oncotarget.25497
GLIADIN PEPTIDE P56-68 ENHANCES EPITHELIAL PERMEABILITY IN A 3D ENTEROID MODEL
Thompson, L., Vaida, A., Campbell, B., & Duckworth, C. (2018). GLIADIN PEPTIDE P56-68 ENHANCES EPITHELIAL PERMEABILITY IN A 3D ENTEROID MODEL. In GUT Vol. 67 (pp. A163). doi:10.1136/gutjnl-2018-BSGAbstracts.323
2017
Comparison Of The Human Gastric Microbiota In Hypochlorhydric States Arising As A Result Of Helicobacter pylori-Induced Atrophic Gastritis, Autoimmune Atrophic Gastritis And Proton Pump Inhibitor Use
parsons, B. N., Ijaz, U. Z., D'Amore, R., Burkitt, M. D., Eccles, R., Lenzi, L., . . . Pritchard, D. M. (2017). Comparison Of The Human Gastric Microbiota In Hypochlorhydric States Arising As A Result Of Helicobacter pylori-Induced Atrophic Gastritis, Autoimmune Atrophic Gastritis And Proton Pump Inhibitor Use. PLoS Pathogens. doi:10.1101/144907
Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use
Parsons, B. N., Ijaz, U. Z., D'Amore, R., Burkitt, M. D., Eccles, R., Lenzi, L., . . . Pritchard, D. M. (2017). Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use. PLoS Pathogens, 13(11). doi:10.1371/journal.ppat.1006653
Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration
Burkitt, M. D., Williams, J. M., Townsend, T., Hough, R., & Pritchard, D. M. (2017). Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration. CELL DEATH & DISEASE, 8. doi:10.1038/cddis.2017.332
Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration.
Burkitt, M., Williams, J., Townsend, T., Hough, R., Duckworth, C., & Pritchard, D. M. (2017). Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration.. Cell Death and Disease. doi:10.1101/112656
Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury
Carr, D. F., Ayehunie, S., Davies, A., Duckworth, C. A., French, S., Hall, N., . . . Pirmohamed, M. (2017). Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury. PHARMACOLOGY & THERAPEUTICS, 172, 181-194. doi:10.1016/j.pharmthera.2017.01.002
<i>Helicobacter pylori</i>-induced gastric pathology: insights from <i>in vivo</i> and ex <i>vivo</i> models
Burkitt, M. D., Duckworth, C. A., Williams, J. M., & Pritchard, D. M. (2017). <i>Helicobacter pylori</i>-induced gastric pathology: insights from <i>in vivo</i> and ex <i>vivo</i> models. DISEASE MODELS & MECHANISMS, 10(2), 89-104. doi:10.1242/dmm.027649
2016
Overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating chemokine expression
Duckworth, C., Zhang, L., Carroll, S. L., Ethier, S. P., & Cheung, H. W. (2016). Overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating chemokine expression. ONCOGENE, 35(31), 4036-4047. doi:10.1038/onc.2015.472
ANTI-CD3 ANTIBODY INDUCES T-CELL MEDIATED APOPTOSIS AND SHEDDING OF MURINE SMALL INTESTINAL EPITHELIAL CELLS
Elramli, A. H., Duckworth, C. A., Campbell, B. J., & Pritchard, D. M. (2016). ANTI-CD3 ANTIBODY INDUCES T-CELL MEDIATED APOPTOSIS AND SHEDDING OF MURINE SMALL INTESTINAL EPITHELIAL CELLS. In GUT Vol. 65 (pp. A75). doi:10.1136/gutjnl-2016-312388.134
Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis
Merga, Y. J., O Hara, A., Burkitt, M. D., Duckworth, C. A., Probert, C. S., Campbell, B. J., & Pritchard, D. M. (2016). Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis. American Journal of Physiology - Gastrointestinal and Liver Physiology, 310(11), G1081-G1090. doi:10.1152/ajpgi.00026.2016
Intestinal Preparation Techniques for Histological Analysis in the Mouse.
Williams, J. M., Duckworth, C. A., Vowell, K., Burkitt, M. D., & Pritchard, D. M. (2016). Intestinal Preparation Techniques for Histological Analysis in the Mouse.. Current protocols in mouse biology, 6(2), 148-168. doi:10.1002/cpmo.2
2015
Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis
Duckworth, C. A., Guimond, S. E., Sindrewicz, P., Hughes, A. J., French, N. S., Lian, L. -Y., . . . Yu, L. -G. (2015). Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis. ONCOTARGET, 6(27), 23671-23687. doi:10.18632/oncotarget.4409
bak deletion stimulates gastric epithelial proliferation and enhances <i>Helicobacter felis</i>-induced gastric atrophy and dysplasia in mice
Duckworth, C. A., Abuderman, A. A., Burkitt, M. D., Williams, J. M., O'Reilly, L. A., & Pritchard, D. M. (2015). bak deletion stimulates gastric epithelial proliferation and enhances <i>Helicobacter felis</i>-induced gastric atrophy and dysplasia in mice. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 309(6), G420-G430. doi:10.1152/ajpgi.00404.2014
NF-kappaB1, NF-kappaB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice
Burkitt, M., Hanedi, A. F., Duckworth, C., Williams, J. M., Tang, J. M., O'Reilly, L. A., . . . Pritchard, M. (2015). NF-kappaB1, NF-kappaB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice. The Journal of Pathology, 236(3), 326-336. doi:10.1002/path.4527
CONFOCAL ENDOMICROSCOPY DEMONSTRATES INCREASED INTESTINAL PERMEABILITY AND GUT DYSFUNCTION IN PATIENTS WITH ACUTE AND CHRONIC PANCREATITIS
Bharucha, S., Geraghty, J., Duckworth, C., Armstrong, J., Szatmary, P., Winn, S., . . . Sutton, R. (2015). CONFOCAL ENDOMICROSCOPY DEMONSTRATES INCREASED INTESTINAL PERMEABILITY AND GUT DYSFUNCTION IN PATIENTS WITH ACUTE AND CHRONIC PANCREATITIS. In GUT Vol. 64 (pp. A307). doi:10.1136/gutjnl-2015-309861.663
Murine Models of Helicobacter (pylori or felis)-associated Gastric Cancer.
Duckworth, C. A., Burkitt, M. D., Williams, J. M., Parsons, B. N., Tang, J. M. F., & Pritchard, D. M. (2015). Murine Models of Helicobacter (pylori or felis)-associated Gastric Cancer.. Current protocols in pharmacology, 69, 14.34.1-14.34.35. doi:10.1002/0471141755.ph1434s69
OC-043 Nfkb1 deficiency alters susceptibility to helicobacter spp. induced il-1Β secretion in bone marrow derived dendritic cells
Tang, J. M., Pritchard, D. M., Duckworth, C. A., Caamano, J., & Burkitt, M. D. (2015). OC-043 Nfkb1 deficiency alters susceptibility to helicobacter spp. induced il-1Β secretion in bone marrow derived dendritic cells. Gut, 64(Suppl 1), A22.2-A23. doi:10.1136/gutjnl-2015-309861.43
TAMOXIFEN INDUCED GASTRIC ATROPHY IS REGULATED BY THE NF-B SUBUNIT NFKB1
Williams, J. M., Norman, R., Tang, J. M., Duckworth, C. A., Caamano, J., Pritchard, D. M., & Burkitt, M. D. (2015). TAMOXIFEN INDUCED GASTRIC ATROPHY IS REGULATED BY THE NF-B SUBUNIT NFKB1. In GUT Vol. 64 (pp. A482). doi:10.1136/gutjnl-2015-309861.1056
Epithelial Cell Shedding and Barrier Function: A Matter of Life and Death at the Small Intestinal Villus Tip
Williams, J. M., Duckworth, C. A., Burkitt, M. D., Watson, A. J. M., Campbell, B. J., & Pritchard, D. M. (2015). Epithelial Cell Shedding and Barrier Function: A Matter of Life and Death at the Small Intestinal Villus Tip. VETERINARY PATHOLOGY, 52(3), 445-455. doi:10.1177/0300985814559404
25 Intestinal Epithelial Cell Specific Deletion of Nfkb2 Protects Against Immune Cell Derived Damage-Inducing Factors in an Enteroid and Bone Marrow Derived Dendritic Cell Co-Culture System
Burkitt, M. D., Jones, L. G., Caamano, J., Pritchard, D. M., & Duckworth, C. A. (2015). 25 Intestinal Epithelial Cell Specific Deletion of Nfkb2 Protects Against Immune Cell Derived Damage-Inducing Factors in an Enteroid and Bone Marrow Derived Dendritic Cell Co-Culture System. Gastroenterology, 148(4). doi:10.1016/s0016-5085(15)30025-1
606 NFKB1 Deficiency Alters Susceptibility to Helicobacter spp. Induced IL-1β Secretion in Bone Marrow Derived Dendritic Cells
Tang, J. M., Duckworth, C. A., Pritchard, D. M., Caamano, J., & Burkitt, M. D. (2015). 606 NFKB1 Deficiency Alters Susceptibility to Helicobacter spp. Induced IL-1β Secretion in Bone Marrow Derived Dendritic Cells. Gastroenterology, 148(4), S-118. doi:10.1016/s0016-5085(15)30409-1
760 Confocal Endomicroscopy Demonstrates Increased Intestinal Permeability and Gut Dysfunction in Patients With Acute and Chronic Pancreatitis
Bharucha, S., Geraghty, J., Duckworth, C. A., Armstrong, J., Szatmary, P., Winn, S. A., . . . Sutton, R. (2015). 760 Confocal Endomicroscopy Demonstrates Increased Intestinal Permeability and Gut Dysfunction in Patients With Acute and Chronic Pancreatitis. Gastroenterology, 148(4), S-145. doi:10.1016/s0016-5085(15)30495-9
Su1973 Tamoxifen Induced Gastric Atrophy Is Regulated by the NF-κB Subunit NFKB1
Williams, J. M., Norman, R., Tang, J. M., Caamano, J., Duckworth, C. A., Pritchard, D. M., & Burkitt, M. D. (2015). Su1973 Tamoxifen Induced Gastric Atrophy Is Regulated by the NF-κB Subunit NFKB1. Gastroenterology, 148(4), S-565. doi:10.1016/s0016-5085(15)31902-8
<i>NFKB1</i> Deficiency Alters Susceptibility to <i>Helicobacter spp</i>. Induced IL-1β Secretion in Bone Marrow Derived Dendritic Cells
Tang, J. M., Duckworth, C. A., Pritchard, D. M., Caamano, J., & Burkitt, M. D. (2015). <i>NFKB1</i> Deficiency Alters Susceptibility to <i>Helicobacter spp</i>. Induced IL-1β Secretion in Bone Marrow Derived Dendritic Cells. In GASTROENTEROLOGY Vol. 148 (pp. S118). Retrieved from https://www.webofscience.com/
Confocal Endomicroscopy Demonstrates Increased Intestinal Permeability and Gut Dysfunction in Patients With Acute and Chronic Pancreatitis
Bharucha, S., Geraghty, J., Duckworth, C. A., Armstrong, J., Szatmary, P., Winn, S. A., . . . Sutton, R. (2015). Confocal Endomicroscopy Demonstrates Increased Intestinal Permeability and Gut Dysfunction in Patients With Acute and Chronic Pancreatitis. In GASTROENTEROLOGY Vol. 148 (pp. S145). Retrieved from https://www.webofscience.com/
Intestinal Epithelial Cell Specific Deletion of Nfkb2 Protects Against Immune Cell Derived Damage-Inducing Factors in an Enteroid and Bone Marrow Derived Dendritic Cell Co-Culture System
Burkitt, M. D., Jones, L. G., Caamano, J., Pritchard, D. M., & Duckworth, C. A. (2015). Intestinal Epithelial Cell Specific Deletion of Nfkb2 Protects Against Immune Cell Derived Damage-Inducing Factors in an Enteroid and Bone Marrow Derived Dendritic Cell Co-Culture System. In GASTROENTEROLOGY Vol. 148 (pp. S8-S9). Retrieved from https://www.webofscience.com/
NFKB1 DEFICIENCY ALTERS SUSCEPTIBILITY TO HELICOBACTER SPP. INDUCED IL-1 SECRETION IN BONE MARROW DERIVED DENDRITIC CELLS
Tang, J. M., Pritchard, D. M., Duckworth, C. A., Caamano, J., & Burkitt, M. D. (2015). NFKB1 DEFICIENCY ALTERS SUSCEPTIBILITY TO HELICOBACTER SPP. INDUCED IL-1 SECRETION IN BONE MARROW DERIVED DENDRITIC CELLS. In GUT Vol. 64 (pp. A22-A23). Retrieved from https://www.webofscience.com/
Tamoxifen Induced Gastric Atrophy Is Regulated by the NF-κB Subunit NFKB1
Williams, J. M., Norman, R., Tang, J. M., Caamano, J., Duckworth, C. A., Pritchard, D. M., & Burkitt, M. D. (2015). Tamoxifen Induced Gastric Atrophy Is Regulated by the NF-κB Subunit NFKB1. In GASTROENTEROLOGY Vol. 148 (pp. S565). Retrieved from https://www.webofscience.com/
2014
Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galactin-3 to promote metastasis by interaction with cancer-associated MUC1
Zhao, Q., Duckworth, C. A., Wang, W. K., Guo, X., Barrow, H., Pritchard, D. M., . . . Yu, L. G. (2014). Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galactin-3 to promote metastasis by interaction with cancer-associated MUC1. Carcinogenesis, 35(12), 2815-2821. doi:10.1093/carcin/bgu216
Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galectin-3 to promote metastasis by interaction with cancer-associated MUC1
Zhao, Q., Duckworth, C. A., Wang, W., Guo, X., Barrow, H., Pritchard, D. M., . . . Yu, L. -G. (2014). Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galectin-3 to promote metastasis by interaction with cancer-associated MUC1. Carcinogenesis, 35(12), 2815-2821. doi:10.1093/carcin/bgu216
A METABOLOMIC PROFILING STUDY OF A CHEMICALLY-INDUCED MOUSE MODEL OF INTESTINAL INFLAMMATION
Reade, S., Duckworth, C. A., Khalid, T., Mayor, A., Aggio, R., Pritchard, D. M., & Probert, C. S. (2014). A METABOLOMIC PROFILING STUDY OF A CHEMICALLY-INDUCED MOUSE MODEL OF INTESTINAL INFLAMMATION. In GUT Vol. 63 (pp. A172). doi:10.1136/gutjnl-2014-307263.369
PWE-109 A Metabolomic Profiling Study Of A Chemically-induced Mouse Model Of Intestinal Inflammation
Reade, S., Duckworth, C. A., Khalid, T., Mayor, A., Aggio, R., Pritchard, D. M., & Probert, C. S. (2014). PWE-109 A Metabolomic Profiling Study Of A Chemically-induced Mouse Model Of Intestinal Inflammation. In Gut Vol. 63 (pp. A172).
Circulating galectins-2,-4 and-8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis
Chen, C., Duckworth, C. A., Fu, B., Pritchard, D. M., Rhodes, J. M., & Yu, L. -G. (2014). Circulating galectins-2,-4 and-8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis. BRITISH JOURNAL OF CANCER, 110(3), 741-752. doi:10.1038/bjc.2013.793
Circulating galectins -2, -4 and -8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis
Chen, C., Duckworth, C. A., Fu, B., Pritchard, D. M., Rhodes, J. M., & Yu, L. G. (2014). Circulating galectins -2, -4 and -8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis. Br J Cancer, 110(3), 741-752. doi:10.1038/bjc.2013.793
Deletion of specific NF-κB proteins regulates susceptibility to colitis associated adenoma development in C57BL/6 mice as a result of altered inflammatory and DNA damage responses
Burkitt, M. D., Hanedi, A., Duckworth, C. A., Williams, J. M., Dimaline, R., Caamano, J., & Pritchard, D. M. (2014). Deletion of specific NF-κB proteins regulates susceptibility to colitis associated adenoma development in C57BL/6 mice as a result of altered inflammatory and DNA damage responses. PLOS Genetics.
2013
Signaling mediated by the NF-κB sub-units NF-κB1, NF-κB2 and c-Rel differentially regulate <i>Helicobacter felis</i>-induced gastric carcinogenesis in C57BL/6 mice
Burkitt, M. D., Williams, J. M., Duckworth, C. A., O'Hara, A., Hanedi, A., Varro, A., . . . Pritchard, D. M. (2013). Signaling mediated by the NF-κB sub-units NF-κB1, NF-κB2 and c-Rel differentially regulate <i>Helicobacter felis</i>-induced gastric carcinogenesis in C57BL/6 mice. ONCOGENE, 32(50), 5563-5573. doi:10.1038/onc.2013.334
A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide
Williams, J. M., Duckworth, C. A., Watson, A. J. M., Frey, M. R., Miguel, J. C., Burkitt, M. D., . . . Pritchard, D. M. (2013). A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide. DISEASE MODELS & MECHANISMS, 6(6), 1388-1399. doi:10.1242/dmm.013284
752 Deletion of Specific NFκB Proteins Regulates Susceptibility to Developing Colitis Associated Cancer in C57BL/6 Mice As a Result of Altered Inflammatory and DNA Damage Responses
Hanedi, A., Burkitt, M. D., Williams, J. M., Duckworth, C. A., Caamano, J., & Pritchard, D. M. (2013). 752 Deletion of Specific NFκB Proteins Regulates Susceptibility to Developing Colitis Associated Cancer in C57BL/6 Mice As a Result of Altered Inflammatory and DNA Damage Responses. Gastroenterology, 144(5), S-136. doi:10.1016/s0016-5085(13)60492-8
Mo1807 Lipopolysaccharide Induces Small Intestinal Epithelial Cell Apoptosis and Shedding by a TLR4 and TNFR1 Dependent Mechanism, Which Is Regulated by NFκB Signalling
Williams, J. M., Duckworth, C. A., Campbell, B. J., Frey, M. R., Miguel, J. C., Burkitt, M. D., . . . Pritchard, D. M. (2013). Mo1807 Lipopolysaccharide Induces Small Intestinal Epithelial Cell Apoptosis and Shedding by a TLR4 and TNFR1 Dependent Mechanism, Which Is Regulated by NFκB Signalling. Gastroenterology, 144(5), S-668. doi:10.1016/s0016-5085(13)62476-2
Increased Circulation of Galectin-3 in Cancer Induces Secretion of Metastasis-Promoting Cytokines from Blood Vascular Endothelium
Chen, C., Duckworth, C. A., Zhao, Q., Pritchard, D. M., Rhodes, J. M., & Yu, L. -G. (2013). Increased Circulation of Galectin-3 in Cancer Induces Secretion of Metastasis-Promoting Cytokines from Blood Vascular Endothelium. CLINICAL CANCER RESEARCH, 19(7), 1693-1704. doi:10.1158/1078-0432.CCR-12-2940
Suppression of Core 1 Gal-Transferase Is Associated with Reduction of TF and Reciprocal Increase of Tn, sialyl-Tn and Core 3 Glycans in Human Colon Cancer Cells
Barrow, H., Tam, B., Duckworth, C. A., Rhodes, J. M., & Yu, L. -G. (2013). Suppression of Core 1 Gal-Transferase Is Associated with Reduction of TF and Reciprocal Increase of Tn, sialyl-Tn and Core 3 Glycans in Human Colon Cancer Cells. PLOS ONE, 8(3). doi:10.1371/journal.pone.0059792
A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide
Williams, J. M., Duckworth, C. A., Watson, A. J. M., Frey, M. R., Miguel, J. C., Burkitt, M. D., . . . Pritchard, M. D. (2013). A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide. Disease Models & Mechanisms.
Deletion of Specific NFκB Proteins Regulates Susceptibility to Developing Colitis Associated Cancer in C57BL/6 Mice As a Result of Altered Inflammatory and DNA Damage Responses
Hanedi, A., Burkitt, M. D., Williams, J. M., Duckworth, C. A., Caamano, J., & Pritchard, D. M. (2013). Deletion of Specific NFκB Proteins Regulates Susceptibility to Developing Colitis Associated Cancer in C57BL/6 Mice As a Result of Altered Inflammatory and DNA Damage Responses. GASTROENTEROLOGY, 144(5), S136. Retrieved from https://www.webofscience.com/
Galectins in the blood circulation: potential therapeutic targets of cancer metastasis
Duckworth, C. A., & Yu, L. G. (2013). Galectins in the blood circulation: potential therapeutic targets of cancer metastasis. ACS, 115, 310-322.
Lipopolysaccharide Induces Small Intestinal Epithelial Cell Apoptosis and Shedding by a TLR4 and TNFR1 Dependent Mechanism, Which Is Regulated by NFκB Signalling
Williams, J. M., Duckworth, C. A., Campbell, B. J., Frey, M. R., Miguel, J. C., Burkitt, M. D., . . . Pritchard, D. M. (2013). Lipopolysaccharide Induces Small Intestinal Epithelial Cell Apoptosis and Shedding by a TLR4 and TNFR1 Dependent Mechanism, Which Is Regulated by NFκB Signalling. GASTROENTEROLOGY, 144(5), S668. Retrieved from https://www.webofscience.com/
Progastrin-Induced Secretion of Insulin-Like Growth Factor 2 From Colonic Myofibroblasts Stimulates Colonic Epithelial Proliferation in Mice
Duckworth, C. A., Clyde, D., Worthley, D. L., Wang, T. C., Varro, A., & Pritchard, D. M. (2013). Progastrin-Induced Secretion of Insulin-Like Growth Factor 2 From Colonic Myofibroblasts Stimulates Colonic Epithelial Proliferation in Mice. GASTROENTEROLOGY, 145(1), 197-+. doi:10.1053/j.gastro.2013.03.012
2012
Galectins in the Blood Circulation: Potential Therapeutic Targets of Cancer Metastasis
Duckworth, C. A., & Yu, L. -G. (2012). Galectins in the Blood Circulation: Potential Therapeutic Targets of Cancer Metastasis. In Unknown Book (Vol. 1115, pp. 309-+). Retrieved from https://www.webofscience.com/
CD24 is expressed in gastric parietal cells and regulates apoptosis and the response to <i>Helicobacter felis</i> infection in the murine stomach
Duckworth, C. A., Clyde, D., & Pritchard, D. M. (2012). CD24 is expressed in gastric parietal cells and regulates apoptosis and the response to <i>Helicobacter felis</i> infection in the murine stomach. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 303(8), G915-G926. doi:10.1152/ajpgi.00068.2012
Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease
Kiesslich, R., Duckworth, C. A., Moussata, D., Gloeckner, A., Lim, L. G., Goetz, M., . . . Watson, A. J. M. (2012). Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease. GUT, 61(8), 1146-1153. doi:10.1136/gutjnl-2011-300695
Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease
Kiesslich, R., Duckworth, C. A., Moussata, D., Gloeckner, A., Lim, L. G., Goetz, M., . . . Watson, A. J. M. (2012). Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease. Gut, 61(8), 1146-1153. doi:10.1136/gutjnl-2011-300695
ALTERED TRAIL, CASPASE12, BAK AND FAS-L EXPRESSIONS ARE ASSOCIATED WITH INCREASED SUSCEPTIBILITY TO RADIATION INDUCED INTESTINAL EPITHELIAL APOPTOSIS IN NF-κ B1-NULL AND NF-κ B2-NULL MICE
Hanedi, A., Burkitt, M. D., Duckworth, C. A., Dimaline, R., Caamano, J. H., & Pritchard, D. M. (2012). ALTERED TRAIL, CASPASE12, BAK AND FAS-L EXPRESSIONS ARE ASSOCIATED WITH INCREASED SUSCEPTIBILITY TO RADIATION INDUCED INTESTINAL EPITHELIAL APOPTOSIS IN NF-κ B1-NULL AND NF-κ B2-NULL MICE. GUT, 61, A8-A9. doi:10.1136/gutjnl-2012-302514a.19
LIPOPOLYSACCHARIDE INDUCES SMALL INTESTINAL EPITHELIAL CELL APOPTOSIS AND SHEDDING WHICH IS REGULATED BY NFκB SIGNALLING
Williams, J. M., Duckworth, C. A., Campbell, B. J., & Pritchard, D. M. (2012). LIPOPOLYSACCHARIDE INDUCES SMALL INTESTINAL EPITHELIAL CELL APOPTOSIS AND SHEDDING WHICH IS REGULATED BY NFκB SIGNALLING. GUT, 61, A342. doi:10.1136/gutjnl-2012-302514d.111
NF-κB2 DELETION PROTECTS MURINE COLON AGAINST DSS-INDUCED COLITIS AND THIS IS ASSOCIATED WITH REDUCED EXPRESSION OF TNF-α AND IL14
Hanedi, A., Burkitt, M. D., Duckworth, C. A., Dimaline, R., Caamano, J. H., & Pritchard, D. M. (2012). NF-κB2 DELETION PROTECTS MURINE COLON AGAINST DSS-INDUCED COLITIS AND THIS IS ASSOCIATED WITH REDUCED EXPRESSION OF TNF-α AND IL14. GUT, 61, A165-A166. doi:10.1136/gutjnl-2012-302514b.224
2011
Bak Deficiency Alters Gastric Epithelial Homeostasis and Modulates the Consequences of Helicobacter felis Infection In Vivo
Duckworth, C. A., Abuderman, A. A., Burkitt, M. D., & Pritchard, D. M. (2011). Bak Deficiency Alters Gastric Epithelial Homeostasis and Modulates the Consequences of Helicobacter felis Infection In Vivo. Gastroenterology, 140(5), S-824. doi:10.1016/s0016-5085(11)63414-8
CD24 Co-Localises With DCAMKL-1 in the Intestine and Regulates Epithelial Apoptosis and Crypt Regeneration Following Damage Inducing Stimuli
Duckworth, C. A., Clyde, D., & Pritchard, D. M. (2011). CD24 Co-Localises With DCAMKL-1 in the Intestine and Regulates Epithelial Apoptosis and Crypt Regeneration Following Damage Inducing Stimuli. Gastroenterology, 140(5), S-6. doi:10.1016/s0016-5085(11)60026-7
Classical and Alternative Pathway Nuclear Factor-κB Signalling Regulate Gastric Epithelial Responses to γ-Irradiation
Burkitt, M. D., Duckworth, C. A., Varro, A., Caamano, J., & Pritchard, D. M. (2011). Classical and Alternative Pathway Nuclear Factor-κB Signalling Regulate Gastric Epithelial Responses to γ-Irradiation. Gastroenterology, 140(5), S-823. doi:10.1016/s0016-5085(11)63410-0
Epithelial Cell Shedding is Followed by Leakage of Circulatory Components and is Modulated by Luminal Osmolarity
Duckworth, C. A., Moussata, D., Kiesslich, R., & Watson, A. J. (2011). Epithelial Cell Shedding is Followed by Leakage of Circulatory Components and is Modulated by Luminal Osmolarity. Gastroenterology, 140(5), S-63. doi:10.1016/s0016-5085(11)60258-8
Progastrin Stimulates Colonic Myofibroblast Proliferation In Vitro and Its Transgenic Overexpression Increases Colonic Myofibroblast Abundance In Vivo
Clyde, D., Duckworth, C. A., Varro, A., Wang, T. C., & Pritchard, D. M. (2011). Progastrin Stimulates Colonic Myofibroblast Proliferation In Vitro and Its Transgenic Overexpression Increases Colonic Myofibroblast Abundance In Vivo. Gastroenterology, 140(5), S-106. doi:10.1016/s0016-5085(11)60429-0
CLASSICAL AND ALTERNATIVE PATHWAY NF-KB SIGNALLING REGULATE GASTRIC EPITHELIAL RESPONSES TO GAMMA-IRRADIATION
Burkitt, M. D., Duckworth, C. A., Varro, A., Caamano, J. H., & Pritchard, D. M. (2011). CLASSICAL AND ALTERNATIVE PATHWAY NF-KB SIGNALLING REGULATE GASTRIC EPITHELIAL RESPONSES TO GAMMA-IRRADIATION. GUT, 60, A9. doi:10.1136/gut.2011.239301.17
NF-KB1 AND NF-KB2 REGULATE SUSCEPTIBILITY TO DNA DAMAGE INDUCED INTESTINAL EPITHELIAL APOPTOSIS IN VIVO
Hanedi, A., Duckworth, C. A., Burkitt, M. D., Caamano, J. H., & Pritchard, D. M. (2011). NF-KB1 AND NF-KB2 REGULATE SUSCEPTIBILITY TO DNA DAMAGE INDUCED INTESTINAL EPITHELIAL APOPTOSIS IN VIVO. In GUT Vol. 60. doi:10.1136/gut.2011.239301.39
Analysis of Epithelial Cell Shedding and Gaps in the Intestinal Epithelium
Duckworth, C. A., & Watson, A. J. (2011). Analysis of Epithelial Cell Shedding and Gaps in the Intestinal Epithelium. PERMEABILITY BARRIER: METHODS AND PROTOCOLS, 763, 105-114. doi:10.1007/978-1-61779-191-8_7
Bak Deficiency Alters Gastric Epithelial Homeostasis and Modulates the Consequences of Helicobacter fells Infection <i>In Vivo</i>
Duckworth, C. A., Abuderman, A. A., Burkitt, M. D., & Pritchard, D. M. (2011). Bak Deficiency Alters Gastric Epithelial Homeostasis and Modulates the Consequences of Helicobacter fells Infection <i>In Vivo</i>. GASTROENTEROLOGY, 140(5), S824. Retrieved from https://www.webofscience.com/
CD24 Co-Localises With DCAMKL-1 in the Intestine and Regulates Epithelial Apoptosis and Crypt Regeneration Following Damage Inducing Stimuli
Duckworth, C. A., Clyde, D., & Pritchard, D. M. (2011). CD24 Co-Localises With DCAMKL-1 in the Intestine and Regulates Epithelial Apoptosis and Crypt Regeneration Following Damage Inducing Stimuli. GASTROENTEROLOGY, 140(5), S6. Retrieved from https://www.webofscience.com/
Classical and Alternative Pathway Nuclear Factor-κB Signalling Regulate Gastric Epithelial Responses to γ-Irradiation
Burkitt, M. D., Duckworth, C. A., Varro, A., Caamano, J., & Pritchard, D. M. (2011). Classical and Alternative Pathway Nuclear Factor-κB Signalling Regulate Gastric Epithelial Responses to γ-Irradiation. GASTROENTEROLOGY, 140(5), S823. Retrieved from https://www.webofscience.com/
Deletion of Bak Leads to Expansion of the Stem Cell Niche in Murine Colonic Crypts
Duckworth, C. A., Stezhka, T., & Pritchard, D. M. (2011). Deletion of Bak Leads to Expansion of the Stem Cell Niche in Murine Colonic Crypts. GASTROENTEROLOGY, 140(5), S39-S40. Retrieved from https://www.webofscience.com/
Epithelial Cell Shedding is Followed by Leakage of Circulatory Components and is Modulated by Luminal Osmolarity
Duckworth, C. A., Moussata, D., Kiesslich, R., & Watson, A. J. (2011). Epithelial Cell Shedding is Followed by Leakage of Circulatory Components and is Modulated by Luminal Osmolarity. GASTROENTEROLOGY, 140(5), S63. Retrieved from https://www.webofscience.com/
NF-κB1 and NF-κB2 regulate susceptibility to DNA damage induced intestinal epithelial apopotosis in vivo
Hanedi, A., Duckworth, C. A., Burkitt, M. D., Caamano, J. H., & Pritchard, D. M. (2011). NF-κB1 and NF-κB2 regulate susceptibility to DNA damage induced intestinal epithelial apopotosis in vivo. Gut, 60, A9.
Progastrin stimulates colonic myofibroblast proliferation in vitro and its transgenic over-expression increases colonic myofibroblast abundance in vivo
Clyde, D., Duckworth, C. A., Varro, A., Wang, T. C., & Pritchard, D. M. (2011). Progastrin stimulates colonic myofibroblast proliferation in vitro and its transgenic over-expression increases colonic myofibroblast abundance in vivo. Gastroenterology, 140(5), S106.
The Epithelial Barrier Is Maintained by In Vivo Tight Junction Expansion During Pathologic Intestinal Epithelial Shedding
Marchiando, A. M., Shen, L., Graham, W. V., Edelblum, K. L., Duckworth, C. A., Guan, Y., . . . Watson, A. J. M. (2011). The Epithelial Barrier Is Maintained by In Vivo Tight Junction Expansion During Pathologic Intestinal Epithelial Shedding. GASTROENTEROLOGY, 140(4), 1208-+. doi:10.1053/j.gastro.2011.01.004
Understanding gene-environment interactions in a mouse model of Crohn's disease
Duckworth, C. A. (2011). Understanding gene-environment interactions in a mouse model of Crohn's disease. DISEASE MODELS & MECHANISMS, 4(1), 7-8. doi:10.1242/dmm.007120
2010
Gut microbiota control gut permeability through GLP-2.
Watson, A. J. M., & Duckworth, C. A. (2010). Gut microbiota control gut permeability through GLP-2.. Gastroenterology, 138(2), 779-781. doi:10.1053/j.gastro.2009.12.017
2009
Mechanisms of Epithelial Cell Shedding in the Mammalian Intestine and Maintenance of Barrier Function
Watson, A. J. M., Duckworth, C. A., Guan, Y., & Montrose, M. H. (2009). Mechanisms of Epithelial Cell Shedding in the Mammalian Intestine and Maintenance of Barrier Function. MOLECULAR STRUCTURE AND FUNCTION OF THE TIGHT JUNCTION: FROM BASIC MECHANISMS TO CLINICAL MANIFESTATIONS, 1165, 135-142. doi:10.1111/j.1749-6632.2009.04027.x
Suppression of Apoptosis, Crypt Hyperplasia, and Altered Differentiation in the Colonic Epithelia of <i>Bak</i>-Null Mice
Duckworth, C. A., & Pritchard, D. M. (2009). Suppression of Apoptosis, Crypt Hyperplasia, and Altered Differentiation in the Colonic Epithelia of <i>Bak</i>-Null Mice. GASTROENTEROLOGY, 136(3), 943-952. doi:10.1053/j.gastro.2008.11.036
2008
Genetic regulation of intestinal epithelial homeostasis in health and following injury
Duckworth, C. A. (2008). Genetic regulation of intestinal epithelial homeostasis in health and following injury. (PhD Thesis, The University of Liverpool).
2007
Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2
Przemeck, S. M. C., Duckworth, C. A., & Pritchard, D. M. (2007). Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 292(2), G620-G627. doi:10.1152/ajpgi.00391.2006
Bak-null mice demonstrate suppression of epithelial apoptosis, crypt hyperplasia and altered differentiation in the colon, and are more susceptible to colonic carcinogenesis
Duckworth, C. A., & Pritchard, D. M. (2007). Bak-null mice demonstrate suppression of epithelial apoptosis, crypt hyperplasia and altered differentiation in the colon, and are more susceptible to colonic carcinogenesis. GASTROENTEROLOGY, 132(4), A154. Retrieved from https://www.webofscience.com/
2006
Gastrin and members of the bcl-2 family regulate gastric epithelial apoptosis in vivo
Przemeck, S., Duckworth, C. A., Varro, A., Pritchard, D., & Pritchard, M. (2006). Gastrin and members of the bcl-2 family regulate gastric epithelial apoptosis in vivo. GUT, 55, A61. Retrieved from https://www.webofscience.com/
Gastrin increases murine intestinal crypt regeneration following injury
Ottewell, P. D., Duckworth, C. A., Varro, A., Dimaline, R., Wang, T. C., Watson, A. J. M., . . . Pritchard, D. M. (2006). Gastrin increases murine intestinal crypt regeneration following injury. GASTROENTEROLOGY, 130(4), 1169-1180. doi:10.1053/j.gastro.2005.12.033
Suppression of colonic epithelial apoptosis and crypt hyperplasia occurs in <i>bak</i>-null mice
Duckworth, C. A., & Pritchard, D. M. (2006). Suppression of colonic epithelial apoptosis and crypt hyperplasia occurs in <i>bak</i>-null mice. GUT, 55, A9. Retrieved from https://www.webofscience.com/
2005
Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced intestinal mucositis in mice.
Duckworth, C. A., Ottewell, P. D., Varro, A., Dimaline, R., & Pritchard, D. M. (2005). Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced intestinal mucositis in mice.. GASTROENTEROLOGY, 128(4), A203. Retrieved from https://www.webofscience.com/
Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced mucositis in mice
Duckworth, C. A., Ottewell, P. D., Dimaline, R., Varro, A., & Pritchard, D. M. (2005). Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced mucositis in mice. GUT, 54, A98. Retrieved from https://www.webofscience.com/
1992
THE EFFECT OF CARRIER TEMPERATURE ON PESTICIDE EMULSIFICATION OR DISPERSION CHARACTERISTICS
DUCKWORTH, C. A., & CEARNAL, K. S. (1992). THE EFFECT OF CARRIER TEMPERATURE ON PESTICIDE EMULSIFICATION OR DISPERSION CHARACTERISTICS. In PESTICIDE FORMULATIONS AND APPLICATION SYSTEMS : 11TH VOLUME Vol. 1112 (pp. 97-104). doi:10.1520/STP16874S
1987
USE OF LANTHANIDE(III) IONS AS CATALYSTS FOR THE REACTIONS OF AMINES WITH NITRILES
FORSBERG, J. H., SPAZIANO, V. T., BALASUBRAMANIAN, T. M., LIU, G. K., KINSLEY, S. A., DUCKWORTH, C. A., . . . MILLER, J. L. (1987). USE OF LANTHANIDE(III) IONS AS CATALYSTS FOR THE REACTIONS OF AMINES WITH NITRILES. JOURNAL OF ORGANIC CHEMISTRY, 52(6), 1017-1021. doi:10.1021/jo00382a009