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2024

Peroxiredoxin 2 mediates redox-stimulated adaptations to oxidative phosphorylation induced by contractile activity in human skeletal muscle myotubes.

Heaton, R. A., Ball, S. T., Staunton, C. A., Mouly, V., Jones, S. W., McArdle, A., & Jackson, M. J. (2024). Peroxiredoxin 2 mediates redox-stimulated adaptations to oxidative phosphorylation induced by contractile activity in human skeletal muscle myotubes.. Free radical biology & medicine, S0891-5849(24)01097-9. doi:10.1016/j.freeradbiomed.2024.11.053

DOI
10.1016/j.freeradbiomed.2024.11.053
Journal article

Peroxiredoxin 2 mediates redox-stimulated adaptations to oxidative phosphorylation induced by contractile activity in human skeletal muscle myotubes

DOI
10.1101/2024.09.23.611634
Preprint

Skeletal muscle aquaporin function and role in redox signalling

Staunton, C. A., Peterson, M. P., Heaton, R. A., Jackson, M. J., & Barrett-Jolley, R. (2024). Skeletal muscle aquaporin function and role in redox signalling. Free Radical Biology and Medicine, 218, 38-39. doi:10.1016/j.freeradbiomed.2024.04.139

DOI
10.1016/j.freeradbiomed.2024.04.139
Journal article

2023

Chapter 6 The effect of maternal and early-life nutrition on redox homeostasis

Ersoy, U., Alameddine, M., Kanakis, I., Staunton, C. A., Peffers, M. J., Jackson, M. J., . . . Vasilaki, A. (2023). Chapter 6 The effect of maternal and early-life nutrition on redox homeostasis. In Modulation of Oxidative Stress (pp. 71-80). Elsevier. doi:10.1016/b978-0-443-19247-0.00002-3

DOI
10.1016/b978-0-443-19247-0.00002-3
Chapter

The effect of maternal and early-life nutrition on redox homeostasis

Ersoy, U., Alameddine, M., Kanakis, I., Staunton, C. A., Peffers, M. J., Jackson, M. J., . . . Vasilaki, A. (2023). The effect of maternal and early-life nutrition on redox homeostasis. In Modulation of Oxidative Stress (pp. 71-80). Elsevier. doi:10.1016/b978-0-443-19247-0.00002-3

DOI
10.1016/b978-0-443-19247-0.00002-3
Chapter

2022

Aquaporins: regulators of H2O2 transport and homeostasis in skeletal muscle

Staunton, C. A., Jones, S., McArdle, A., Jackson, M., & Barrett-Jolley, R. (2022). Aquaporins: regulators of H2O2 transport and homeostasis in skeletal muscle. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 192. doi:10.1016/j.freeradbiomed.2022.10.024

DOI
10.1016/j.freeradbiomed.2022.10.024
Conference Paper

Altered oxidative DNA damage repair systems in muscles of old mice: role in the age-related increase in muscle production of cytokines/chemokines

Kumiscia, K., Shigdar, S., Owen, E., Staunton, C. A., Proctor, C. J., Jackson, M. J., . . . McArdle, A. (2022). Altered oxidative DNA damage repair systems in muscles of old mice: role in the age-related increase in muscle production of cytokines/chemokines. FASEB JOURNAL, 36. doi:10.1096/fasebj.2022.36.S1.R4404

DOI
10.1096/fasebj.2022.36.S1.R4404
Journal article

Combined transcriptomic, proteomic and synthesis profiling reveal distinct proteostatic signatures for skeletal muscle of adult and old mice

Staunton, C. A., Owen, E. D., Hemmings, K., Jackson, M. J., Barrett-Jolley, R., Hammond, D., . . . McArdle, A. (2022). Combined transcriptomic, proteomic and synthesis profiling reveal distinct proteostatic signatures for skeletal muscle of adult and old mice. FASEB JOURNAL, 36. doi:10.1096/fasebj.2022.36.S1.R4458

DOI
10.1096/fasebj.2022.36.S1.R4458
Journal article

Cytokine and Chemokine Release from Immortalised Human Myotubes in Culture: Effect of Contractions and Comparison with Isolated Intact Mature Adult Murine Muscle Fibres

Neiland, H. J., Staunton, C. A., Owen, E., Kumiscia, J., Shigdar, S., Jones, S. W., . . . McArdle, A. (2022). Cytokine and Chemokine Release from Immortalised Human Myotubes in Culture: Effect of Contractions and Comparison with Isolated Intact Mature Adult Murine Muscle Fibres. FASEB JOURNAL, 36. doi:10.1096/fasehj.2022.36.S1.L7908

DOI
10.1096/fasehj.2022.36.S1.L7908
Journal article

Deletion of <i>Sod1</i> in motor neurons exacerbates age-related changes in axons and NMJs associated with premature muscle atrophy in aging mice

DOI
10.1101/2022.01.27.477840
Preprint

Temperature modulates PVN pre-sympathetic neurones via transient receptor potential ion channels

DOI
10.1101/2022.01.26.477880
Preprint

2021

Redox cross talk from motor nerves to skeletal muscle regulates muscle redox homeostasis

Jackson, M. J., Pollock, N., Staunton, C., Hemmings, K., Vasilaki, A., & McArdle, A. (2021). Redox cross talk from motor nerves to skeletal muscle regulates muscle redox homeostasis. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 177. doi:10.1016/j.freeradbiomed.2021.08.047

DOI
10.1016/j.freeradbiomed.2021.08.047
Conference Paper

Systemic application of the TRPV4 antagonist GSK2193874 induces tail vasodilation in a mouse model of thermoregulation

O’Brien, F., Staunton, C., & Barrett-Jolley, R. (2021). Systemic application of the TRPV4 antagonist GSK2193874 induces tail vasodilation in a mouse model of thermoregulation. doi:10.1101/2021.03.12.435126

DOI
10.1101/2021.03.12.435126
Journal article

Development of age-related loss of muscle mass and function - role of oxidative DNA damage repair systems

Kumiscia, K., Shigdar, S., Proctor, C., Shanley, D., Owen, E., Staunton, C., . . . McArdle, A. (2021). Development of age-related loss of muscle mass and function - role of oxidative DNA damage repair systems. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 165. doi:10.1016/j.freeradbiomed.2020.12.339

DOI
10.1016/j.freeradbiomed.2020.12.339
Conference Paper

Development of age-related loss of muscle mass and function – role of oxidative DNA damage repair systems

Kumiscia, K., Shigdar, S., Proctor, C., Shanley, D., Owen, E., Staunton, C., . . . McArdle, A. (2021). Development of age-related loss of muscle mass and function – role of oxidative DNA damage repair systems. Free Radical Biology and Medicine, 165, 30-31. doi:10.1016/j.freeradbiomed.2020.12.335

DOI
10.1016/j.freeradbiomed.2020.12.335
Journal article

Extracellular Vesicle Production by Skeletal Muscle: Role in Neuromuscular Ageing

Hemmings, K., Pollock, N., Owen, E., Staunton, C., Brooks, S. V., & McArdle, A. (2021). Extracellular Vesicle Production by Skeletal Muscle: Role in Neuromuscular Ageing. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 165. doi:10.1016/j.freeradbiomed.2020.12.334

DOI
10.1016/j.freeradbiomed.2020.12.334
Conference Paper

Neuron specific lack of SOD1 leads to accelerated age-related loss of NMJ structure

Pollock, N., Hemmings, K., Staunton, C. A., Owen, E. D., Scalabrin, M., Vasilaki, A., . . . Jackson, M. J. (2021). Neuron specific lack of SOD1 leads to accelerated age-related loss of NMJ structure. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 165. doi:10.1016/j.freeradbiomed.2020.12.304

DOI
10.1016/j.freeradbiomed.2020.12.304
Conference Paper

2020

Exosomal Signaling by Skeletal Muscle: Role in Neuromuscular Ageing

Hemmings, K., Girithananda, A., Robertson, R., Pugh, J., Scalabrin, M., Mora, S., & McArdle, A. (2019). Exosomal Signaling by Skeletal Muscle: Role in Neuromuscular Ageing. In FASEB JOURNAL Vol. 33. Retrieved from https://www.webofscience.com/

Conference Paper

Exosomal Signaling by Skeletal Muscle: Role in Neuromuscular Ageing

Hemmings, K., Owen, E., Staunton, C., Pollock, N., Brooks, S. V., & McArdle, A. (2020). Exosomal Signaling by Skeletal Muscle: Role in Neuromuscular Ageing. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 159 (pp. S105-S106). doi:10.1016/j.freeradbiomed.2020.10.268

DOI
10.1016/j.freeradbiomed.2020.10.268
Conference Paper

Lack of SOD1 In Neuronal Tissue Affects Neuromuscular Junction Stability in Advanced Age

Pollock, N., Hemmings, K., Staunton, C., Owen, E., MacPherson, P., Vasilaki, A., . . . Jackson, M. (2020). Lack of SOD1 In Neuronal Tissue Affects Neuromuscular Junction Stability in Advanced Age. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 159 (pp. S108-S109). doi:10.1016/j.freeradbiomed.2020.10.275

DOI
10.1016/j.freeradbiomed.2020.10.275
Conference Paper

Transcriptomic analysis of skeletal muscle ageing: focus on neurotrophic factors and ROS-related genes

Staunton, C., McArdle, A., Barrett-Jolley, R., & Jackson, M. (2020). Transcriptomic analysis of skeletal muscle ageing: focus on neurotrophic factors and ROS-related genes. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 159 (pp. S110-S111). doi:10.1016/j.freeradbiomed.2020.10.280

DOI
10.1016/j.freeradbiomed.2020.10.280
Conference Paper

Altered Redox Signalling in both Muscle and Nerve are Required for Neuromuscular Breakdown

Pollock, N., Hemmings, K., Staunton, C., Owen, E., Scalabrin, M., Macpherson, P., . . . Jackson, M. (2020). Altered Redox Signalling in both Muscle and Nerve are Required for Neuromuscular Breakdown. In FASEB JOURNAL Vol. 34. doi:10.1096/fasebj.2020.34.s1.05492

DOI
10.1096/fasebj.2020.34.s1.05492
Conference Paper

Genomic Profiling and Physiological Approaches to Understand Aquaporins and their Role in ROS Signalling within Skeletal Muscle

Staunton, C., Vasilaki, A., McArdle, A., Jackson, M., & Barrett-Jolley, R. (2020). Genomic Profiling and Physiological Approaches to Understand Aquaporins and their Role in ROS Signalling within Skeletal Muscle. In FASEB JOURNAL Vol. 34. doi:10.1096/fasebj.2020.34.s1.02026

DOI
10.1096/fasebj.2020.34.s1.02026
Conference Paper

Rates of Synthesis of Individual Proteins in Muscles of Old Mice: A Heavy Water Approach

Owen, E., Hammond, D., Staunton, C., Franco, C., Prescott, M., Brooks, S., . . . McArdle, A. (2020). Rates of Synthesis of Individual Proteins in Muscles of Old Mice: A Heavy Water Approach. In FASEB JOURNAL Vol. 34. doi:10.1096/fasebj.2020.34.s1.06592

DOI
10.1096/fasebj.2020.34.s1.06592
Conference Paper

The Contribution of Environment to Impair Re-Innervation in Age-Related Failure of Muscle Regeneration Following

Pollock, N., Owen, E., Staunton, C., Davis, C., Vasilaki, A., Richardson, A., . . . McArdle, A. (2020). The Contribution of Environment to Impair Re-Innervation in Age-Related Failure of Muscle Regeneration Following. In FASEB JOURNAL Vol. 34. doi:10.1096/fasebj.2020.34.s1.05784

DOI
10.1096/fasebj.2020.34.s1.05784
Conference Paper

Pro-inflammatory cytokines drive deregulation of potassium channel expression in primary synovial fibroblasts

Haidar, O., O’Neill, N., Staunton, C. A., Bavan, S., O’Brien, F., Zouggari, S., . . . Barrett-Jolley, R. (2020). Pro-inflammatory cytokines drive deregulation of potassium channel expression in primary synovial fibroblasts. doi:10.1101/2020.02.06.937078

DOI
10.1101/2020.02.06.937078
Journal article

Chapter 34 Oxidative stress in skeletal muscle: Unraveling the potential beneficial and deleterious roles of reactive oxygen species

Jackson, M. J., Pollock, N., Staunton, C. A., Stretton, C., Vasilaki, A., & McArdle, A. (2020). Chapter 34 Oxidative stress in skeletal muscle: Unraveling the potential beneficial and deleterious roles of reactive oxygen species. In Oxidative Stress (pp. 713-733). Elsevier. doi:10.1016/b978-0-12-818606-0.00034-1

DOI
10.1016/b978-0-12-818606-0.00034-1
Chapter

2019

Aquaporin transport of hydrogen peroxide in skeletal muscle

Staunton, C. A., Vasilaki, A., McArdle, A., Jackson, M. J., & Barrett‐Jolley, R. (2019). Aquaporin transport of hydrogen peroxide in skeletal muscle. The FASEB Journal, 33(S1). doi:10.1096/fasebj.2019.33.1_supplement.lb644

DOI
10.1096/fasebj.2019.33.1_supplement.lb644
Journal article

Genomic Profiling using RNAseq to identify key drivers of sarcopenia and motor unit turnover in murine skeletal muscle

Staunton, C. A., Vasilaki, A., Barrett-Jolley, R., McArdle, A., & Jackson, M. (2019). Genomic Profiling using RNAseq to identify key drivers of sarcopenia and motor unit turnover in murine skeletal muscle. In FASEB JOURNAL Vol. 33. Retrieved from https://www.webofscience.com/

Conference Paper

Neuromuscular Junction Structure and Redox Status of Skeletal Muscle Fiber: Effect on Schwann Cells

Pollock, N., Scalabrin, M., Staunton, C. A., Vasilaki, A., Van Remmen, H., Richardson, A., . . . Jackson, M. J. (2019). Neuromuscular Junction Structure and Redox Status of Skeletal Muscle Fiber: Effect on Schwann Cells. In FASEB JOURNAL Vol. 33. Retrieved from https://www.webofscience.com/

Conference Paper

Oxidative stress in skeletal muscle: Unraveling the potential beneficial and deleterious roles of reactive oxygen species

Jackson, M. J., Pollock, N., Staunton, C. A., Stretton, C., Vasilaki, A., & McArdle, A. (2020). Oxidative stress in skeletal muscle: Unraveling the potential beneficial and deleterious roles of reactive oxygen species. In OXIDATIVE STRESS: EUSTRESS AND DISTRESS (pp. 713-733). doi:10.1016/B978-0-12-818606-0.00034-1

DOI
10.1016/B978-0-12-818606-0.00034-1
Chapter

Reactive oxygen species in age-related decline of skeletal muscle and the musculoskeletal system

Jackson, M., McArdle, A., Pollock, N., Staunton, C., Stretton, C., & Vasilaki, A. (2019). Reactive oxygen species in age-related decline of skeletal muscle and the musculoskeletal system. In EUROPEAN JOURNAL OF CLINICAL INVESTIGATION Vol. 49 (pp. 46). Retrieved from https://www.webofscience.com/

Conference Paper

2018

Aberrant redox signaling in age-related muscle decline

McArdle, A., Pollock, N., Staunton, C. A., Owen, E., Shigdar, S., Scalabrin, M., . . . Jackson, M. J. (2018). Aberrant redox signaling in age-related muscle decline. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 120 (pp. S13-S14). doi:10.1016/j.freeradbiomed.2018.04.059

DOI
10.1016/j.freeradbiomed.2018.04.059
Conference Paper

ANALYSIS OF ANION CHANNEL ACTIVITY IN CHONDROCYTES IN VITRO MODEL OF OSTEOARTHRITIS

Kumagai, K., Toyoda, F., Staunton, C., Sharif, U., Lewis, R., Maeda, T., . . . Barrett-Jolley, R. (2018). ANALYSIS OF ANION CHANNEL ACTIVITY IN CHONDROCYTES IN VITRO MODEL OF OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S104). doi:10.1016/j.joca.2018.02.226

DOI
10.1016/j.joca.2018.02.226
Conference Paper

Do senescent cells drive the ageing phenotype of skeletal muscle in vivo?

Shigdar, S., Staunton, C., Vasilaki, A., & McArdle, A. (2018). Do senescent cells drive the ageing phenotype of skeletal muscle in vivo?. The FASEB Journal, 32(S1). doi:10.1096/fasebj.2018.32.1_supplement.907.3

DOI
10.1096/fasebj.2018.32.1_supplement.907.3
Journal article

Ion Channel Activity in a 3‐hydroxyacyl‐coA dehydratase 1 (HACD1) Deficient Muscle Cell Line

Morgan, R. S., Walmsley, G., Dyer, S., O'Brien, F., Staunton, C., Blondelle, J., . . . Barrett‐Jolley, R. (2018). Ion Channel Activity in a 3‐hydroxyacyl‐coA dehydratase 1 (HACD1) Deficient Muscle Cell Line. The FASEB Journal, 32(S1). doi:10.1096/fasebj.2018.32.1_supplement.lb484

DOI
10.1096/fasebj.2018.32.1_supplement.lb484
Journal article

Do senescent cells drive the ageing phenotype of skeletal muscle in vivo?

Shigdar, S., Staunton, C., Vasilaki, A., & McArdle, A. (2018). Do senescent cells drive the ageing phenotype of skeletal muscle in vivo?. In FASEB JOURNAL Vol. 32. Retrieved from https://www.webofscience.com/

Conference Paper

Ion Channel Activity in a 3-hydroxyacyl-coA dehydratase 1 (HACD1) Deficient Muscle Cell Line

Morgan, R. S., Walmsley, G., Dyer, S., O'Brien, F., Staunton, C., Blondelle, J., . . . Barrett-Jolley, R. (2018). Ion Channel Activity in a 3-hydroxyacyl-coA dehydratase 1 (HACD1) Deficient Muscle Cell Line. In FASEB JOURNAL Vol. 32. Retrieved from https://www.webofscience.com/

Conference Paper

Novel intravital assessment of muscle cytosol H<sub>2</sub>0<sub>2</sub> content supports a key role for motor unit remodelling in sarcopenia.

Staunton, C. A., Vasilaki, A., Barrett-Jolley, R., McArdle, A., & Jackson, M. J. (2018). Novel intravital assessment of muscle cytosol H<sub>2</sub>0<sub>2</sub> content supports a key role for motor unit remodelling in sarcopenia.. In FASEB JOURNAL Vol. 32. Retrieved from https://www.webofscience.com/

Conference Paper

Senescence in Myoblasts; Role in Age-Related Muscle Dysfunction

Shigdar, S., Staunton, C., Vasilaki, A., & McArdle, A. (2018). Senescence in Myoblasts; Role in Age-Related Muscle Dysfunction. In FASEB JOURNAL Vol. 32. Retrieved from https://www.webofscience.com/

Conference Paper

2017

Neuromuscular regeneration following whole muscle transplantation

Pollock, N., Davis, C. S., Hassett, C. A., Staunton, C. A., Vasilaki, A., Jackson, M. J., . . . McArdle, A. (2017). Neuromuscular regeneration following whole muscle transplantation. In FASEB JOURNAL Vol. 31. Retrieved from https://www.webofscience.com/

Conference Paper

The role of hydrogen peroxide production in skeletal muscle dysfunction following nerve crush.

Staunton, C. A., Pollock, N., Vasilaki, A., Barrett-Jolley, R., McArdle, A., & Jackson, M. J. (2017). The role of hydrogen peroxide production in skeletal muscle dysfunction following nerve crush.. In FASEB JOURNAL Vol. 31. Retrieved from https://www.webofscience.com/

Conference Paper

2016

Effect of Partial Denervation on Mitochondrial ROS Generation in Skeletal Muscle; a Role in Sarcopenia?

Pollock, N., Staunton, C. A., Vasilaki, A., McArdle, A., & Jackson, M. J. (2016). Effect of Partial Denervation on Mitochondrial ROS Generation in Skeletal Muscle; a Role in Sarcopenia?. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 100 (pp. S86-S87). doi:10.1016/j.freeradbiomed.2016.10.216

DOI
10.1016/j.freeradbiomed.2016.10.216
Conference Paper

The Role of Denervation in Cytokine-Mediated Muscle Dysfunction in Old Mice

Staunton, C. A., Pollock, N., McCormick, R., Vasilaki, A., Barrett-Jolley, R., Jackson, M., & McArdle, A. (2016). The Role of Denervation in Cytokine-Mediated Muscle Dysfunction in Old Mice. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 100 (pp. S89). doi:10.1016/j.freeradbiomed.2016.10.222

DOI
10.1016/j.freeradbiomed.2016.10.222
Conference Paper

Activation of a chondrocyte volume-sensitive Cl(-) conductance prior to macroscopic cartilage lesion formation in the rabbit knee anterior cruciate ligament transection osteoarthritis model.

Kumagai, K., Toyoda, F., staunton, C., Maeda, T., Okumura, N., Matsuura, H., . . . Barrett-jolley, R. (2016). Activation of a chondrocyte volume-sensitive Cl(-) conductance prior to macroscopic cartilage lesion formation in the rabbit knee anterior cruciate ligament transection osteoarthritis model.. Osteoarthritis and Cartilage, 24(10), 1786-1794. doi:10.1016/j.joca.2016.05.019

DOI
10.1016/j.joca.2016.05.019
Journal article

Age-related neuromuscular deficits in reactive oxygen species generation in exercising skeletal muscle

Jackson, M. J., Vasilaki, A., Pollock, N., Staunton, C., McDonagh, B., & McArdle, A. (2016). Age-related neuromuscular deficits in reactive oxygen species generation in exercising skeletal muscle. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 96 (pp. S13). doi:10.1016/j.freeradbiomed.2016.04.059

DOI
10.1016/j.freeradbiomed.2016.04.059
Conference Paper

Effect of partial denervation mitochondrial ROS generation in skeletal muscle

Pollock, N., Staunton, C. A., Vasilaki, A., McArdle, A., & Jackson, M. (2016). Effect of partial denervation mitochondrial ROS generation in skeletal muscle. In FASEB JOURNAL Vol. 30. Retrieved from https://www.webofscience.com/

Conference Paper

Effects of TNFα challenge on sensory neuron ion channel expression and temperature sensitivity

Staunton, C. A., Kumagai, K. A., Thippeswamy, T., Djourhi, L., & Barrett-Jolley, R. A. (2016). Effects of TNFα challenge on sensory neuron ion channel expression and temperature sensitivity. In FASEB JOURNAL Vol. 30. Retrieved from https://www.webofscience.com/

Conference Paper

The role of denervation in cytokine-mediated muscle dysfunction in muscles of old mice

Staunton, C. A., Pollock, N., Lightfoot, A., Vasilaki, A., Barrett-Jolley, R., McArdle, A., & Jackson, M. (2016). The role of denervation in cytokine-mediated muscle dysfunction in muscles of old mice. In FASEB JOURNAL Vol. 30. Retrieved from https://www.webofscience.com/

Conference Paper

2015

Nutrigenomics, Inflammaging, and Osteoarthritis

Mobasheri, A., Barrett‐Jolley, R., Staunton, C. A., Ford, C., & Henrotin, Y. (2015). Nutrigenomics, Inflammaging, and Osteoarthritis. In Unknown Book (pp. 71-84). Wiley. doi:10.1002/9781118930458.ch7

DOI
10.1002/9781118930458.ch7
Chapter

Cytokine Expression Profiles and Electrophysiological Recordings of Dorsal Root Ganglion Cells in an <i>In Vitro</i> Model of Chronic Pain

Staunton, C., Barrett-Jolley, R., Djouhri, L., & Thippeswamy, T. (2015). Cytokine Expression Profiles and Electrophysiological Recordings of Dorsal Root Ganglion Cells in an <i>In Vitro</i> Model of Chronic Pain. In FASEB JOURNAL Vol. 29. Retrieved from https://www.webofscience.com/

Conference Paper

2014

2013