Publications

Selected publications

Skeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing (Journal article - 2022)
HyPer2 imaging reveals temporal and heterogeneous hydrogen peroxide changes in denervated and aged skeletal muscle fibers in vivo (Journal article - 2019)

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2024

Peroxiredoxin 2 mediates redox-stimulated adaptations to oxidative phosphorylation induced by contractile activity in human skeletal muscle myotubes

DOI: 10.1101/2024.09.23.611634
: Preprint

Skeletal muscle aquaporin function and role in redox signalling

Staunton, C. A., Peterson, M. P., Heaton, R. A., Jackson, M. J., & Barrett-Jolley, R. (2024). Skeletal muscle aquaporin function and role in redox signalling. Free Radical Biology and Medicine, 218, 38-39. doi:10.1016/j.freeradbiomed.2024.04.139

DOI: 10.1016/j.freeradbiomed.2024.04.139
: Journal article

2023

Deletion of Sod1 in Motor Neurons Exacerbates Age-Related Changes in Axons and Neuromuscular Junctions in Mice.

Pollock, N., Macpherson, P. C., Staunton, C. A., Hemmings, K., Davis, C. S., Owen, E. D., . . . Jackson, M. J. (2023). Deletion of Sod1 in Motor Neurons Exacerbates Age-Related Changes in Axons and Neuromuscular Junctions in Mice.. eNeuro, 10(3), ENEURO.0086-ENEU22.2023. doi:10.1523/eneuro.0086-22.2023

DOI: 10.1523/eneuro.0086-22.2023
: Journal article

Chapter 6 The effect of maternal and early-life nutrition on redox homeostasis

Ersoy, U., Alameddine, M., Kanakis, I., Staunton, C. A., Peffers, M. J., Jackson, M. J., . . . Vasilaki, A. (2023). Chapter 6 The effect of maternal and early-life nutrition on redox homeostasis. In Modulation of Oxidative Stress (pp. 71-80). Elsevier. doi:10.1016/b978-0-443-19247-0.00002-3

DOI: 10.1016/b978-0-443-19247-0.00002-3
: Chapter

Temperature modulates PVN pre-sympathetic neurones via transient receptor potential ion channels.

O'Brien, F., Feetham, C. H., Staunton, C. A., Hext, K., & Barrett-Jolley, R. (2023). Temperature modulates PVN pre-sympathetic neurones via transient receptor potential ion channels.. Frontiers in pharmacology, 14, 1256924. doi:10.3389/fphar.2023.1256924

DOI: 10.3389/fphar.2023.1256924
: Journal article

The effect of maternal and early-life nutrition on redox homeostasis

Ersoy, U., Alameddine, M., Kanakis, I., Staunton, C. A., Peffers, M. J., Jackson, M. J., . . . Vasilaki, A. (2023). The effect of maternal and early-life nutrition on redox homeostasis. In Modulation of Oxidative Stress (pp. 71-80). Elsevier. doi:10.1016/b978-0-443-19247-0.00002-3

DOI: 10.1016/b978-0-443-19247-0.00002-3
: Chapter

2022

Aquaporins: regulators of H2O2 transport and homeostasis in skeletal muscle

Staunton, C. A., Jones, S., McArdle, A., Jackson, M., & Barrett-Jolley, R. (2022). Aquaporins: regulators of H2O2 transport and homeostasis in skeletal muscle. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 192. doi:10.1016/j.freeradbiomed.2022.10.024

DOI: 10.1016/j.freeradbiomed.2022.10.024
: Conference Paper

Systemic application of the transient receptor potential vanilloid-type 4 antagonist GSK2193874 induces tail vasodilation in a mouse model of thermoregulation

O'Brien, F., Staunton, C. A., & Barrett-Jolley, R. (2022). Systemic application of the transient receptor potential vanilloid-type 4 antagonist GSK2193874 induces tail vasodilation in a mouse model of thermoregulation. BIOLOGY LETTERS, 18(6). doi:10.1098/rsbl.2022.0129

DOI: 10.1098/rsbl.2022.0129
: Journal article

Redox Control of Signalling Responses to Contractile Activity and Ageing in Skeletal Muscle

Jackson, M. J., Pollock, N., Staunton, C., Jones, S., & McArdle, A. (2022). Redox Control of Signalling Responses to Contractile Activity and Ageing in Skeletal Muscle. CELLS, 11(10). doi:10.3390/cells11101698

DOI: 10.3390/cells11101698
: Journal article

Altered oxidative DNA damage repair systems in muscles of old mice: role in the age-related increase in muscle production of cytokines/chemokines

Kumiscia, K., Shigdar, S., Owen, E., Staunton, C. A., Proctor, C. J., Jackson, M. J., . . . McArdle, A. (2022). Altered oxidative DNA damage repair systems in muscles of old mice: role in the age-related increase in muscle production of cytokines/chemokines. FASEB JOURNAL, 36. doi:10.1096/fasebj.2022.36.S1.R4404

DOI: 10.1096/fasebj.2022.36.S1.R4404
: Journal article

Combined transcriptomic, proteomic and synthesis profiling reveal distinct proteostatic signatures for skeletal muscle of adult and old mice

Staunton, C. A., Owen, E. D., Hemmings, K., Jackson, M. J., Barrett-Jolley, R., Hammond, D., . . . McArdle, A. (2022). Combined transcriptomic, proteomic and synthesis profiling reveal distinct proteostatic signatures for skeletal muscle of adult and old mice. FASEB JOURNAL, 36. doi:10.1096/fasebj.2022.36.S1.R4458

DOI: 10.1096/fasebj.2022.36.S1.R4458
: Journal article

Cytokine and Chemokine Release from Immortalised Human Myotubes in Culture: Effect of Contractions and Comparison with Isolated Intact Mature Adult Murine Muscle Fibres

Neiland, H. J., Staunton, C. A., Owen, E., Kumiscia, J., Shigdar, S., Jones, S. W., . . . McArdle, A. (2022). Cytokine and Chemokine Release from Immortalised Human Myotubes in Culture: Effect of Contractions and Comparison with Isolated Intact Mature Adult Murine Muscle Fibres. FASEB JOURNAL, 36. doi:10.1096/fasehj.2022.36.S1.L7908

DOI: 10.1096/fasehj.2022.36.S1.L7908
: Journal article

Skeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing

Staunton, C. A., Owen, E. D., Hemmings, K., Vasilaki, A., McArdle, A., Barrett-Jolley, R., & Jackson, M. J. (2022). Skeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing. SKELETAL MUSCLE, 12(1). doi:10.1186/s13395-021-00283-4

DOI: 10.1186/s13395-021-00283-4
: Journal article

Deletion of Sod1 in motor neurons exacerbates age-related changes in axons and NMJs associated with premature muscle atrophy in aging mice

DOI: 10.1101/2022.01.27.477840
: Preprint

Temperature modulates PVN pre-sympathetic neurones via transient receptor potential ion channels

DOI: 10.1101/2022.01.26.477880
: Preprint

2021

Redox cross talk from motor nerves to skeletal muscle regulates muscle redox homeostasis

Jackson, M. J., Pollock, N., Staunton, C., Hemmings, K., Vasilaki, A., & McArdle, A. (2021). Redox cross talk from motor nerves to skeletal muscle regulates muscle redox homeostasis. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 177. doi:10.1016/j.freeradbiomed.2021.08.047

DOI: 10.1016/j.freeradbiomed.2021.08.047
: Conference Paper

Systemic application of the TRPV4 antagonist GSK2193874 induces tail vasodilation in a mouse model of thermoregulation

O’Brien, F., Staunton, C., & Barrett-Jolley, R. (2021). Systemic application of the TRPV4 antagonist GSK2193874 induces tail vasodilation in a mouse model of thermoregulation. doi:10.1101/2021.03.12.435126

DOI: 10.1101/2021.03.12.435126
: Journal article

Development of age-related loss of muscle mass and function - role of oxidative DNA damage repair systems

Kumiscia, K., Shigdar, S., Proctor, C., Shanley, D., Owen, E., Staunton, C., . . . McArdle, A. (2021). Development of age-related loss of muscle mass and function - role of oxidative DNA damage repair systems. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 165. doi:10.1016/j.freeradbiomed.2020.12.339

DOI: 10.1016/j.freeradbiomed.2020.12.339
: Conference Paper

Development of age-related loss of muscle mass and function – role of oxidative DNA damage repair systems

Kumiscia, K., Shigdar, S., Proctor, C., Shanley, D., Owen, E., Staunton, C., . . . McArdle, A. (2021). Development of age-related loss of muscle mass and function – role of oxidative DNA damage repair systems. Free Radical Biology and Medicine, 165, 30-31. doi:10.1016/j.freeradbiomed.2020.12.335

DOI: 10.1016/j.freeradbiomed.2020.12.335
: Journal article

Extracellular Vesicle Production by Skeletal Muscle: Role in Neuromuscular Ageing

Hemmings, K., Pollock, N., Owen, E., Staunton, C., Brooks, S. V., & McArdle, A. (2021). Extracellular Vesicle Production by Skeletal Muscle: Role in Neuromuscular Ageing. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 165. doi:10.1016/j.freeradbiomed.2020.12.334

DOI: 10.1016/j.freeradbiomed.2020.12.334
: Conference Paper

Neuron specific lack of SOD1 leads to accelerated age-related loss of NMJ structure

Pollock, N., Hemmings, K., Staunton, C. A., Owen, E. D., Scalabrin, M., Vasilaki, A., . . . Jackson, M. J. (2021). Neuron specific lack of SOD1 leads to accelerated age-related loss of NMJ structure. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 165. doi:10.1016/j.freeradbiomed.2020.12.304

DOI: 10.1016/j.freeradbiomed.2020.12.304
: Conference Paper

2020

Exosomal Signaling by Skeletal Muscle: Role in Neuromuscular Ageing

Hemmings, K., Owen, E., Staunton, C., Pollock, N., Brooks, S. V., & McArdle, A. (2020). Exosomal Signaling by Skeletal Muscle: Role in Neuromuscular Ageing. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 159 (pp. S105-S106). doi:10.1016/j.freeradbiomed.2020.10.268

DOI: 10.1016/j.freeradbiomed.2020.10.268
: Conference Paper

Exosomal Signaling by Skeletal Muscle: Role in Neuromuscular Ageing

Hemmings, K., Girithananda, A., Robertson, R., Pugh, J., Scalabrin, M., Mora, S., & McArdle, A. (2019). Exosomal Signaling by Skeletal Muscle: Role in Neuromuscular Ageing. In FASEB JOURNAL Vol. 33. Retrieved from https://www.webofscience.com/

: Conference Paper

Lack of SOD1 In Neuronal Tissue Affects Neuromuscular Junction Stability in Advanced Age

Pollock, N., Hemmings, K., Staunton, C., Owen, E., MacPherson, P., Vasilaki, A., . . . Jackson, M. (2020). Lack of SOD1 In Neuronal Tissue Affects Neuromuscular Junction Stability in Advanced Age. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 159 (pp. S108-S109). doi:10.1016/j.freeradbiomed.2020.10.275

DOI: 10.1016/j.freeradbiomed.2020.10.275
: Conference Paper

Transcriptomic analysis of skeletal muscle ageing: focus on neurotrophic factors and ROS-related genes

Staunton, C., McArdle, A., Barrett-Jolley, R., & Jackson, M. (2020). Transcriptomic analysis of skeletal muscle ageing: focus on neurotrophic factors and ROS-related genes. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 159 (pp. S110-S111). doi:10.1016/j.freeradbiomed.2020.10.280

DOI: 10.1016/j.freeradbiomed.2020.10.280
: Conference Paper

Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice

Bhaskaran, S., Pollock, N., Macpherson, P. C., Ahn, B., Piekarz, K. M., Staunton, C. A., . . . Van Remmen, H. (2020). Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice. AGING CELL, 19(10). doi:10.1111/acel.13225

DOI: 10.1111/acel.13225
: Journal article

Altered Redox Signalling in both Muscle and Nerve are Required for Neuromuscular Breakdown

Pollock, N., Hemmings, K., Staunton, C., Owen, E., Scalabrin, M., Macpherson, P., . . . Jackson, M. (2020). Altered Redox Signalling in both Muscle and Nerve are Required for Neuromuscular Breakdown. In FASEB JOURNAL Vol. 34. doi:10.1096/fasebj.2020.34.s1.05492

DOI: 10.1096/fasebj.2020.34.s1.05492
: Conference Paper

Genomic Profiling and Physiological Approaches to Understand Aquaporins and their Role in ROS Signalling within Skeletal Muscle

Staunton, C., Vasilaki, A., McArdle, A., Jackson, M., & Barrett-Jolley, R. (2020). Genomic Profiling and Physiological Approaches to Understand Aquaporins and their Role in ROS Signalling within Skeletal Muscle. In FASEB JOURNAL Vol. 34. doi:10.1096/fasebj.2020.34.s1.02026

DOI: 10.1096/fasebj.2020.34.s1.02026
: Conference Paper

Rates of Synthesis of Individual Proteins in Muscles of Old Mice: A Heavy Water Approach

Owen, E., Hammond, D., Staunton, C., Franco, C., Prescott, M., Brooks, S., . . . McArdle, A. (2020). Rates of Synthesis of Individual Proteins in Muscles of Old Mice: A Heavy Water Approach. In FASEB JOURNAL Vol. 34. doi:10.1096/fasebj.2020.34.s1.06592

DOI: 10.1096/fasebj.2020.34.s1.06592
: Conference Paper

The Contribution of Environment to Impair Re-Innervation in Age-Related Failure of Muscle Regeneration Following

Pollock, N., Owen, E., Staunton, C., Davis, C., Vasilaki, A., Richardson, A., . . . McArdle, A. (2020). The Contribution of Environment to Impair Re-Innervation in Age-Related Failure of Muscle Regeneration Following. In FASEB JOURNAL Vol. 34. doi:10.1096/fasebj.2020.34.s1.05784

DOI: 10.1096/fasebj.2020.34.s1.05784
: Conference Paper

Pro-inflammatory Cytokines Drive Deregulation of Potassium Channel Expression in Primary Synovial Fibroblasts

Haidar, O., O'Neill, N., Staunton, C. A., Bavan, S., O'Brien, F., Zouggari, S., . . . Barrett-Jolley, R. (2020). Pro-inflammatory Cytokines Drive Deregulation of Potassium Channel Expression in Primary Synovial Fibroblasts. FRONTIERS IN PHYSIOLOGY, 11. doi:10.3389/fphys.2020.00226

DOI: 10.3389/fphys.2020.00226
: Journal article

Pro-inflammatory cytokines drive deregulation of potassium channel expression in primary synovial fibroblasts

Haidar, O., O’Neill, N., Staunton, C. A., Bavan, S., O’Brien, F., Zouggari, S., . . . Barrett-Jolley, R. (2020). Pro-inflammatory cytokines drive deregulation of potassium channel expression in primary synovial fibroblasts. doi:10.1101/2020.02.06.937078

DOI: 10.1101/2020.02.06.937078
: Journal article

Chapter 34 Oxidative stress in skeletal muscle: Unraveling the potential beneficial and deleterious roles of reactive oxygen species

Jackson, M. J., Pollock, N., Staunton, C. A., Stretton, C., Vasilaki, A., & McArdle, A. (2020). Chapter 34 Oxidative stress in skeletal muscle: Unraveling the potential beneficial and deleterious roles of reactive oxygen species. In Oxidative Stress (pp. 713-733). Elsevier. doi:10.1016/b978-0-12-818606-0.00034-1

DOI: 10.1016/b978-0-12-818606-0.00034-1
: Chapter

2019

HyPer2 imaging reveals temporal and heterogeneous hydrogen peroxide changes in denervated and aged skeletal muscle fibers in vivo

Staunton, C. A., Owen, E. D., Pollock, N., Vasilaki, A., Barrett-Jolley, R., McArdle, A., & Jackson, M. J. (2019). HyPer2 imaging reveals temporal and heterogeneous hydrogen peroxide changes in denervated and aged skeletal muscle fibers in vivo. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-51035-w

DOI: 10.1038/s41598-019-51035-w
: Journal article

Redox responses in skeletal muscle following denervation

Vasilaki, A. (n.d.). Redox responses in skeletal muscle following denervation. Redox Biology.

: Journal article

Aquaporin transport of hydrogen peroxide in skeletal muscle

Staunton, C. A., Vasilaki, A., McArdle, A., Jackson, M. J., & Barrett‐Jolley, R. (2019). Aquaporin transport of hydrogen peroxide in skeletal muscle. The FASEB Journal, 33(S1). doi:10.1096/fasebj.2019.33.1_supplement.lb644

DOI: 10.1096/fasebj.2019.33.1_supplement.lb644
: Journal article

Genomic Profiling using RNAseq to identify key drivers of sarcopenia and motor unit turnover in murine skeletal muscle

Staunton, C. A., Vasilaki, A., Barrett-Jolley, R., McArdle, A., & Jackson, M. (2019). Genomic Profiling using RNAseq to identify key drivers of sarcopenia and motor unit turnover in murine skeletal muscle. In FASEB JOURNAL Vol. 33. Retrieved from https://www.webofscience.com/

: Conference Paper

Neuromuscular Junction Structure and Redox Status of Skeletal Muscle Fiber: Effect on Schwann Cells

Pollock, N., Scalabrin, M., Staunton, C. A., Vasilaki, A., Van Remmen, H., Richardson, A., . . . Jackson, M. J. (2019). Neuromuscular Junction Structure and Redox Status of Skeletal Muscle Fiber: Effect on Schwann Cells. In FASEB JOURNAL Vol. 33. Retrieved from https://www.webofscience.com/

: Conference Paper

Aberrant redox signalling and stress response in age-related muscle decline: Role in inter- and intra-cellular signalling

McArdle, A., Pollock, N., Staunton, C. A., & Jackson, M. J. (2019). Aberrant redox signalling and stress response in age-related muscle decline: Role in inter- and intra-cellular signalling. FREE RADICAL BIOLOGY AND MEDICINE, 132, 50-57. doi:10.1016/j.freeradbiomed.2018.11.038

DOI: 10.1016/j.freeradbiomed.2018.11.038
: Journal article

Oxidative stress in skeletal muscle: Unraveling the potential beneficial and deleterious roles of reactive oxygen species

Jackson, M. J., Pollock, N., Staunton, C. A., Stretton, C., Vasilaki, A., & McArdle, A. (2020). Oxidative stress in skeletal muscle: Unraveling the potential beneficial and deleterious roles of reactive oxygen species. In OXIDATIVE STRESS: EUSTRESS AND DISTRESS (pp. 713-733). doi:10.1016/B978-0-12-818606-0.00034-1

DOI: 10.1016/B978-0-12-818606-0.00034-1
: Chapter

Reactive oxygen species in age-related decline of skeletal muscle and the musculoskeletal system

Jackson, M., McArdle, A., Pollock, N., Staunton, C., Stretton, C., & Vasilaki, A. (2019). Reactive oxygen species in age-related decline of skeletal muscle and the musculoskeletal system. In EUROPEAN JOURNAL OF CLINICAL INVESTIGATION Vol. 49 (pp. 46). Retrieved from https://www.webofscience.com/

: Conference Paper

2018

Aberrant redox signaling in age-related muscle decline

McArdle, A., Pollock, N., Staunton, C. A., Owen, E., Shigdar, S., Scalabrin, M., . . . Jackson, M. J. (2018). Aberrant redox signaling in age-related muscle decline. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 120 (pp. S13-S14). doi:10.1016/j.freeradbiomed.2018.04.059

DOI: 10.1016/j.freeradbiomed.2018.04.059
: Conference Paper

ANALYSIS OF ANION CHANNEL ACTIVITY IN CHONDROCYTES IN VITRO MODEL OF OSTEOARTHRITIS

Kumagai, K., Toyoda, F., Staunton, C., Sharif, U., Lewis, R., Maeda, T., . . . Barrett-Jolley, R. (2018). ANALYSIS OF ANION CHANNEL ACTIVITY IN CHONDROCYTES IN VITRO MODEL OF OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S104). doi:10.1016/j.joca.2018.02.226

DOI: 10.1016/j.joca.2018.02.226
: Conference Paper

Do senescent cells drive the ageing phenotype of skeletal muscle in vivo?

Shigdar, S., Staunton, C., Vasilaki, A., & McArdle, A. (2018). Do senescent cells drive the ageing phenotype of skeletal muscle in vivo?. The FASEB Journal, 32(S1). doi:10.1096/fasebj.2018.32.1_supplement.907.3

DOI: 10.1096/fasebj.2018.32.1_supplement.907.3
: Journal article

Inducible nitric oxide synthase inhibition by 1400W limits pain hypersensitivity in a neuropathic pain rat model

Staunton, C. A., Barrett-Jolley, R., Djouhri, L., & Thippeswamy, T. (2018). Inducible nitric oxide synthase inhibition by 1400W limits pain hypersensitivity in a neuropathic pain rat model. EXPERIMENTAL PHYSIOLOGY, 103(04), 535-544. doi:10.1113/EP086764

DOI: 10.1113/EP086764
: Journal article

Ion Channel Activity in a 3‐hydroxyacyl‐coA dehydratase 1 (HACD1) Deficient Muscle Cell Line

Morgan, R. S., Walmsley, G., Dyer, S., O'Brien, F., Staunton, C., Blondelle, J., . . . Barrett‐Jolley, R. (2018). Ion Channel Activity in a 3‐hydroxyacyl‐coA dehydratase 1 (HACD1) Deficient Muscle Cell Line. The FASEB Journal, 32(S1). doi:10.1096/fasebj.2018.32.1_supplement.lb484

DOI: 10.1096/fasebj.2018.32.1_supplement.lb484
: Journal article

Do senescent cells drive the ageing phenotype of skeletal muscle in vivo?

Shigdar, S., Staunton, C., Vasilaki, A., & McArdle, A. (2018). Do senescent cells drive the ageing phenotype of skeletal muscle in vivo?. In FASEB JOURNAL Vol. 32. Retrieved from https://www.webofscience.com/

: Conference Paper

Ion Channel Activity in a 3-hydroxyacyl-coA dehydratase 1 (HACD1) Deficient Muscle Cell Line

Morgan, R. S., Walmsley, G., Dyer, S., O'Brien, F., Staunton, C., Blondelle, J., . . . Barrett-Jolley, R. (2018). Ion Channel Activity in a 3-hydroxyacyl-coA dehydratase 1 (HACD1) Deficient Muscle Cell Line. In FASEB JOURNAL Vol. 32. Retrieved from https://www.webofscience.com/

: Conference Paper

Novel intravital assessment of muscle cytosol H202 content supports a key role for motor unit remodelling in sarcopenia.

Staunton, C. A., Vasilaki, A., Barrett-Jolley, R., McArdle, A., & Jackson, M. J. (2018). Novel intravital assessment of muscle cytosol H202 content supports a key role for motor unit remodelling in sarcopenia.. In FASEB JOURNAL Vol. 32. Retrieved from https://www.webofscience.com/

: Conference Paper

Senescence in Myoblasts; Role in Age-Related Muscle Dysfunction

Shigdar, S., Staunton, C., Vasilaki, A., & McArdle, A. (2018). Senescence in Myoblasts; Role in Age-Related Muscle Dysfunction. In FASEB JOURNAL Vol. 32. Retrieved from https://www.webofscience.com/

: Conference Paper

2017

Denervated muscle fibers induce mitochondrial peroxide generation in neighboring innervated fibers: Role in muscle aging

Pollock, N., Staunton, C. A., Vasilaki, A., McArdle, A., & Jackson, M. J. (2017). Denervated muscle fibers induce mitochondrial peroxide generation in neighboring innervated fibers: Role in muscle aging. FREE RADICAL BIOLOGY AND MEDICINE, 112, 84-92. doi:10.1016/j.freeradbiomed.2017.07.017

DOI: 10.1016/j.freeradbiomed.2017.07.017
: Journal article

CHANGES IN ION CHANNEL EXPRESSION IN SYNOVIAL FIBROBLASTS IN AN IN VITRO MODEL OF OSTEOARTHRITIS

Kumagai, K., O'Neill, N., Zouggari, S., Staunton, C. A., Bavany, S., Hadair, O., . . . Barrett-Jolley, R. (2017). CHANGES IN ION CHANNEL EXPRESSION IN SYNOVIAL FIBROBLASTS IN AN IN VITRO MODEL OF OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 25 (pp. S380-S381). doi:10.1016/j.joca.2017.02.651

DOI: 10.1016/j.joca.2017.02.651
: Conference Paper

Neuromuscular regeneration following whole muscle transplantation

Pollock, N., Davis, C. S., Hassett, C. A., Staunton, C. A., Vasilaki, A., Jackson, M. J., . . . McArdle, A. (2017). Neuromuscular regeneration following whole muscle transplantation. In FASEB JOURNAL Vol. 31. Retrieved from https://www.webofscience.com/

: Conference Paper

The role of hydrogen peroxide production in skeletal muscle dysfunction following nerve crush.

Staunton, C. A., Pollock, N., Vasilaki, A., Barrett-Jolley, R., McArdle, A., & Jackson, M. J. (2017). The role of hydrogen peroxide production in skeletal muscle dysfunction following nerve crush.. In FASEB JOURNAL Vol. 31. Retrieved from https://www.webofscience.com/

: Conference Paper

2016

Effect of Partial Denervation on Mitochondrial ROS Generation in Skeletal Muscle; a Role in Sarcopenia?

Pollock, N., Staunton, C. A., Vasilaki, A., McArdle, A., & Jackson, M. J. (2016). Effect of Partial Denervation on Mitochondrial ROS Generation in Skeletal Muscle; a Role in Sarcopenia?. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 100 (pp. S86-S87). doi:10.1016/j.freeradbiomed.2016.10.216

DOI: 10.1016/j.freeradbiomed.2016.10.216
: Conference Paper

The Role of Denervation in Cytokine-Mediated Muscle Dysfunction in Old Mice

Staunton, C. A., Pollock, N., McCormick, R., Vasilaki, A., Barrett-Jolley, R., Jackson, M., & McArdle, A. (2016). The Role of Denervation in Cytokine-Mediated Muscle Dysfunction in Old Mice. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 100 (pp. S89). doi:10.1016/j.freeradbiomed.2016.10.222

DOI: 10.1016/j.freeradbiomed.2016.10.222
: Conference Paper

Activation of a chondrocyte volume-sensitive Cl(-) conductance prior to macroscopic cartilage lesion formation in the rabbit knee anterior cruciate ligament transection osteoarthritis model.

Kumagai, K., Toyoda, F., staunton, C., Maeda, T., Okumura, N., Matsuura, H., . . . Barrett-jolley, R. (2016). Activation of a chondrocyte volume-sensitive Cl(-) conductance prior to macroscopic cartilage lesion formation in the rabbit knee anterior cruciate ligament transection osteoarthritis model.. Osteoarthritis and Cartilage, 24(10), 1786-1794. doi:10.1016/j.joca.2016.05.019

DOI: 10.1016/j.joca.2016.05.019
: Journal article

Age-related neuromuscular deficits in reactive oxygen species generation in exercising skeletal muscle

Jackson, M. J., Vasilaki, A., Pollock, N., Staunton, C., McDonagh, B., & McArdle, A. (2016). Age-related neuromuscular deficits in reactive oxygen species generation in exercising skeletal muscle. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 96 (pp. S13). doi:10.1016/j.freeradbiomed.2016.04.059

DOI: 10.1016/j.freeradbiomed.2016.04.059
: Conference Paper

Effect of partial denervation mitochondrial ROS generation in skeletal muscle

Pollock, N., Staunton, C. A., Vasilaki, A., McArdle, A., & Jackson, M. (2016). Effect of partial denervation mitochondrial ROS generation in skeletal muscle. In FASEB JOURNAL Vol. 30. Retrieved from https://www.webofscience.com/

: Conference Paper

Effects of TNFα challenge on sensory neuron ion channel expression and temperature sensitivity

Staunton, C. A., Kumagai, K. A., Thippeswamy, T., Djourhi, L., & Barrett-Jolley, R. A. (2016). Effects of TNFα challenge on sensory neuron ion channel expression and temperature sensitivity. In FASEB JOURNAL Vol. 30. Retrieved from https://www.webofscience.com/

: Conference Paper

The role of denervation in cytokine-mediated muscle dysfunction in muscles of old mice

Staunton, C. A., Pollock, N., Lightfoot, A., Vasilaki, A., Barrett-Jolley, R., McArdle, A., & Jackson, M. (2016). The role of denervation in cytokine-mediated muscle dysfunction in muscles of old mice. In FASEB JOURNAL Vol. 30. Retrieved from https://www.webofscience.com/

: Conference Paper

2015

Nutrigenomics, Inflammaging, and Osteoarthritis

Mobasheri, A., Barrett‐Jolley, R., Staunton, C. A., Ford, C., & Henrotin, Y. (2015). Nutrigenomics, Inflammaging, and Osteoarthritis. In Unknown Book (pp. 71-84). Wiley. doi:10.1002/9781118930458.ch7

DOI: 10.1002/9781118930458.ch7
: Chapter

An In Vitro Model of Skeletal Muscle Volume Regulation

Wibberley, A., Staunton, C., Feetham, C., Vereninov, A. A., & Barrett-Jolley, R. (2015). An In Vitro Model of Skeletal Muscle Volume Regulation. PLoS One, 10(6). doi:10.1371/journal.pone.0127889

DOI: 10.1371/journal.pone.0127889
: Journal article

Cytokine Expression Profiles and Electrophysiological Recordings of Dorsal Root Ganglion Cells in an In Vitro Model of Chronic Pain

Staunton, C., Barrett-Jolley, R., Djouhri, L., & Thippeswamy, T. (2015). Cytokine Expression Profiles and Electrophysiological Recordings of Dorsal Root Ganglion Cells in an In Vitro Model of Chronic Pain. In FASEB JOURNAL Vol. 29. Retrieved from https://www.webofscience.com/

: Conference Paper

2014

High hopes for cannabinoid agonists in the treatment of rheumatic diseases

Staunton, C. A., Mobasheri, A., & Barrett-Jolley, R. (2014). High hopes for cannabinoid agonists in the treatment of rheumatic diseases. BMC MUSCULOSKELETAL DISORDERS, 15. doi:10.1186/1471-2474-15-410

DOI: 10.1186/1471-2474-15-410
: Journal article

2013

Ion Channels and Osteoarthritic Pain: Potential for Novel Analgesics

Staunton, C. A., Lewis, R., & Barrett-Jolley, R. (2013). Ion Channels and Osteoarthritic Pain: Potential for Novel Analgesics. CURRENT PAIN AND HEADACHE REPORTS, 17(12). doi:10.1007/s11916-013-0378-z

DOI: 10.1007/s11916-013-0378-z
: Journal article

Publications

Selected publications

2024

Peroxiredoxin 2 mediates redox-stimulated adaptations to oxidative phosphorylation induced by contractile activity in human skeletal muscle myotubes

Skeletal muscle aquaporin function and role in redox signalling

2023

Chapter 6 The effect of maternal and early-life nutrition on redox homeostasis

The effect of maternal and early-life nutrition on redox homeostasis

2022

Aquaporins: regulators of H2O2 transport and homeostasis in skeletal muscle

Altered oxidative DNA damage repair systems in muscles of old mice: role in the age-related increase in muscle production of cytokines/chemokines

Combined transcriptomic, proteomic and synthesis profiling reveal distinct proteostatic signatures for skeletal muscle of adult and old mice

Cytokine and Chemokine Release from Immortalised Human Myotubes in Culture: Effect of Contractions and Comparison with Isolated Intact Mature Adult Murine Muscle Fibres

Deletion of <i>Sod1</i> in motor neurons exacerbates age-related changes in axons and NMJs associated with premature muscle atrophy in aging mice

Temperature modulates PVN pre-sympathetic neurones via transient receptor potential ion channels

2021

Redox cross talk from motor nerves to skeletal muscle regulates muscle redox homeostasis

Systemic application of the TRPV4 antagonist GSK2193874 induces tail vasodilation in a mouse model of thermoregulation

Development of age-related loss of muscle mass and function - role of oxidative DNA damage repair systems

Development of age-related loss of muscle mass and function – role of oxidative DNA damage repair systems

Extracellular Vesicle Production by Skeletal Muscle: Role in Neuromuscular Ageing

Neuron specific lack of SOD1 leads to accelerated age-related loss of NMJ structure

2020

Exosomal Signaling by Skeletal Muscle: Role in Neuromuscular Ageing

Exosomal Signaling by Skeletal Muscle: Role in Neuromuscular Ageing

Lack of SOD1 In Neuronal Tissue Affects Neuromuscular Junction Stability in Advanced Age

Transcriptomic analysis of skeletal muscle ageing: focus on neurotrophic factors and ROS-related genes

Altered Redox Signalling in both Muscle and Nerve are Required for Neuromuscular Breakdown

Genomic Profiling and Physiological Approaches to Understand Aquaporins and their Role in ROS Signalling within Skeletal Muscle

Rates of Synthesis of Individual Proteins in Muscles of Old Mice: A Heavy Water Approach

The Contribution of Environment to Impair Re-Innervation in Age-Related Failure of Muscle Regeneration Following

Pro-inflammatory cytokines drive deregulation of potassium channel expression in primary synovial fibroblasts

Chapter 34 Oxidative stress in skeletal muscle: Unraveling the potential beneficial and deleterious roles of reactive oxygen species

2019

Aquaporin transport of hydrogen peroxide in skeletal muscle

Genomic Profiling using RNAseq to identify key drivers of sarcopenia and motor unit turnover in murine skeletal muscle

Neuromuscular Junction Structure and Redox Status of Skeletal Muscle Fiber: Effect on Schwann Cells

Oxidative stress in skeletal muscle: Unraveling the potential beneficial and deleterious roles of reactive oxygen species

Reactive oxygen species in age-related decline of skeletal muscle and the musculoskeletal system

2018

Aberrant redox signaling in age-related muscle decline

ANALYSIS OF ANION CHANNEL ACTIVITY IN CHONDROCYTES IN VITRO MODEL OF OSTEOARTHRITIS

Do senescent cells drive the ageing phenotype of skeletal muscle in vivo?

Ion Channel Activity in a 3‐hydroxyacyl‐coA dehydratase 1 (HACD1) Deficient Muscle Cell Line

Do senescent cells drive the ageing phenotype of skeletal muscle in vivo?

Ion Channel Activity in a 3-hydroxyacyl-coA dehydratase 1 (HACD1) Deficient Muscle Cell Line

Novel intravital assessment of muscle cytosol H<sub>2</sub>0<sub>2</sub> content supports a key role for motor unit remodelling in sarcopenia.

Senescence in Myoblasts; Role in Age-Related Muscle Dysfunction

2017

Neuromuscular regeneration following whole muscle transplantation

The role of hydrogen peroxide production in skeletal muscle dysfunction following nerve crush.

2016

Effect of Partial Denervation on Mitochondrial ROS Generation in Skeletal Muscle; a Role in Sarcopenia?

The Role of Denervation in Cytokine-Mediated Muscle Dysfunction in Old Mice

Age-related neuromuscular deficits in reactive oxygen species generation in exercising skeletal muscle

Effect of partial denervation mitochondrial ROS generation in skeletal muscle

Effects of TNFα challenge on sensory neuron ion channel expression and temperature sensitivity

The role of denervation in cytokine-mediated muscle dysfunction in muscles of old mice

2015

Nutrigenomics, Inflammaging, and Osteoarthritis

Cytokine Expression Profiles and Electrophysiological Recordings of Dorsal Root Ganglion Cells in an <i>In Vitro</i> Model of Chronic Pain

2014

2013