Publications
2024
Deciphering the role of a SINE-VNTR-Alu retrotransposon polymorphism as a biomarker of Parkinson’s disease progression
Fröhlich, A., Pfaff, A. L., Middlehurst, B., Hughes, L. S., Bubb, V. J., Quinn, J. P., & Koks, S. (n.d.). Deciphering the role of a SINE-VNTR-Alu retrotransposon polymorphism as a biomarker of Parkinson’s disease progression. Scientific Reports, 14(1). doi:10.1038/s41598-024-61753-5
A SINE-VNTR-Alu at the LRIG2 locus is associated with proximal and distal gene expression in CRISPR and population models.
Hall, A., Middlehurst, B., Cadogan, M. A. M., Reed, X., Billingsley, K. J., Bubb, V. J., & Quinn, J. P. (2024). A SINE-VNTR-Alu at the LRIG2 locus is associated with proximal and distal gene expression in CRISPR and population models.. Scientific reports, 14(1), 792. doi:10.1038/s41598-023-50307-w
2023
Deciphering the role of a SINE-VNTR-Alu retrotransposon polymorphism as a biomarker of Parkinson’s disease progression
CRISPR deletion of a SINE-VNTR-<i>Alu</i> (SVA_67) retrotransposon demonstrates its ability to differentially modulate gene expression at the <i>MAPT</i> locus.
Fröhlich, A., Hughes, L. S., Middlehurst, B., Pfaff, A. L., Bubb, V. J., Koks, S., & Quinn, J. P. (2023). CRISPR deletion of a SINE-VNTR-<i>Alu</i> (SVA_67) retrotransposon demonstrates its ability to differentially modulate gene expression at the <i>MAPT</i> locus.. Frontiers in neurology, 14, 1273036. doi:10.3389/fneur.2023.1273036
2022
A polymorphic transcriptional regulatory domain in the amyotrophic lateral sclerosis risk gene <i>CFAP410</i> correlates with differential isoform expression.
Marshall, J. N. G., Fröhlich, A., Li, L., Pfaff, A. L., Middlehurst, B., Spargo, T. P., . . . Quinn, J. P. (2022). A polymorphic transcriptional regulatory domain in the amyotrophic lateral sclerosis risk gene <i>CFAP410</i> correlates with differential isoform expression.. Frontiers in molecular neuroscience, 15, 954928. doi:10.3389/fnmol.2022.954928
2021
Restricted differentiative capacity of Wt1-expressing peritoneal mesothelium in postnatal and adult mice
Wilm, T. P., Tanton, H., Mutter, F., Foisor, V., Middlehurst, B., Ward, K., . . . Wilm, B. (2021). Restricted differentiative capacity of Wt1-expressing peritoneal mesothelium in postnatal and adult mice. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-95380-1
The role of endogenous retrotransposable elements in Parkinson’s disease.
Middlehurst, B. (2021, June 16). The role of endogenous retrotransposable elements in Parkinson’s disease..
2020
Restricted differentiative capacity of Wt1-expressing peritoneal mesothelium in postnatal and adult mice
Trypanosoma brucei colonizes the tsetse gut via an immature peritrophic matrix in the proventriculus
Rose, C., Casas-Sanchez, A., Dyer, N. A., Solorzano, C., Beckett, A. J., Middlehurst, B., . . . Acosta-Serrano, A. (2020). Trypanosoma brucei colonizes the tsetse gut via an immature peritrophic matrix in the proventriculus. Nature Microbiology, 5(7), 909-916. doi:10.1038/s41564-020-0707-z
2019
Mitochondria function associated genes contribute to Parkinson's Disease risk and later age at onset
Billingsley, K. J., Barbosa, I. A., Bandres-Ciga, S., Quinn, J. P., Bubb, V. J., Deshpande, C., . . . IPDGC. (2019). Mitochondria function associated genes contribute to Parkinson's Disease risk and later age at onset. NPJ PARKINSONS DISEASE, 5. doi:10.1038/s41531-019-0080-x
Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability
Quinn, J. P., Billingsley, K., Reynolds, R. H., Botia, J., Nalls, M. A., Hardy, J., . . . Ryten, M. (2019). Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability. npj Parkinson's Disease, 5. doi:10.1038/s41531-019-0076-6
2015
The role of Ca2+influx in endocytic vacuole formation in pancreatic acinar cells
Voronina, S., Collier, D., Chvanov, M., Middlehurst, B., Beckett, A., Prior, I., . . . Tepikin, A. V. (2015). The role of Ca2+influx in endocytic vacuole formation in pancreatic acinar cells. Biochemical Journal, 465(3), 405-412. doi:10.1042/BJ20140398