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2024

Talin-1 variants associated with spontaneous coronary artery dissection (SCAD) highlight how even subtle changes in multi-functional scaffold proteins can manifest in disease.

Azizi, L., Otani, Y., Mykuliak, V. V., Goult, B. T., Hytönen, V. P., & Turkki, P. (2024). Talin-1 variants associated with spontaneous coronary artery dissection (SCAD) highlight how even subtle changes in multi-functional scaffold proteins can manifest in disease.. Human molecular genetics, ddae120. doi:10.1093/hmg/ddae120

DOI
10.1093/hmg/ddae120
Journal article

Molecular dynamics simulations reveal how vinculin refolds partially unfolded talin rod helices to stabilize them against mechanical force

Mykuliak, V. V., Rahikainen, R., Ball, N. J., Bussi, G., Goult, B. T., & Hytönen, V. P. (n.d.). Molecular dynamics simulations reveal how vinculin refolds partially unfolded talin rod helices to stabilize them against mechanical force. PLOS Computational Biology, 20(8), e1012341. doi:10.1371/journal.pcbi.1012341

DOI
10.1371/journal.pcbi.1012341
Journal article

2023

2022

A novel cancer-associated cassette exon in <i>TLN1</i> alters Talin 1 mechanosensitivity

DOI
10.1101/2022.09.06.506802
Preprint

2021

Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1

DOI
10.1101/2021.03.19.436208
Preprint

Biochemical Characterization of the Integrin Interactome.

Khan, R. B., Varela, L., Cowell, A. R., & Goult, B. T. (2021). Biochemical Characterization of the Integrin Interactome.. Methods in molecular biology (Clifton, N.J.), 2217, 115-147. doi:10.1007/978-1-0716-0962-0_9

DOI
10.1007/978-1-0716-0962-0_9
Journal article

2020

2019

High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained.

Bryce, N. S., Failes, T. W., Stehn, J. R., Baker, K., Zahler, S., Arzhaeva, Y., . . . Lock, J. G. (2019). High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained.. Cell systems, 9(5), 496-507.e5. doi:10.1016/j.cels.2019.09.002

DOI
10.1016/j.cels.2019.09.002
Journal article

Calcium-mediated Protein Folding and Stabilization of Salmonella Biofilm-associated Protein A.

Guttula, D., Yao, M., Baker, K., Yang, L., Goult, B. T., Doyle, P. S., & Yan, J. (2019). Calcium-mediated Protein Folding and Stabilization of Salmonella Biofilm-associated Protein A.. Journal of molecular biology, 431(2), 433-443. doi:10.1016/j.jmb.2018.11.014

DOI
10.1016/j.jmb.2018.11.014
Journal article

2018

Direct binding of Talin to Rap1 is required for cell-ECM adhesion in <i>Drosophila</i>.

Camp, D., Haage, A., Solianova, V., Castle, W. M., Xu, Q. A., Lostchuck, E., . . . Tanentzapf, G. (2018). Direct binding of Talin to Rap1 is required for cell-ECM adhesion in <i>Drosophila</i>.. Journal of cell science, 131(24), jcs225144. doi:10.1242/jcs.225144

DOI
10.1242/jcs.225144
Journal article

ProLIF - quantitative integrin protein-protein interactions and synergistic membrane effects on proteoliposomes.

De Franceschi, N., Miihkinen, M., Hamidi, H., Alanko, J., Mai, A., Picas, L., . . . Ivaska, J. (2018). ProLIF - quantitative integrin protein-protein interactions and synergistic membrane effects on proteoliposomes.. Journal of cell science, 132(4), jcs214270. doi:10.1242/jcs.214270

DOI
10.1242/jcs.214270
Journal article

A Novel Mechanism for Calmodulin-Dependent Inactivation of Transient Receptor Potential Vanilloid 6.

Bate, N., Caves, R. E., Skinner, S. P., Goult, B. T., Basran, J., Mitcheson, J. S., & Vuister, G. W. (2018). A Novel Mechanism for Calmodulin-Dependent Inactivation of Transient Receptor Potential Vanilloid 6.. Biochemistry, 57(18), 2611-2622. doi:10.1021/acs.biochem.7b01286

DOI
10.1021/acs.biochem.7b01286
Journal article

The Structural Basis of Calcium-Dependent Inactivation of the Transient Receptor Potential Vanilloid 5 Channel.

Bokhovchuk, F. M., Bate, N., Kovalevskaya, N. V., Goult, B. T., Spronk, C. A. E. M., & Vuister, G. W. (2018). The Structural Basis of Calcium-Dependent Inactivation of the Transient Receptor Potential Vanilloid 5 Channel.. Biochemistry, 57(18), 2623-2635. doi:10.1021/acs.biochem.7b01287

DOI
10.1021/acs.biochem.7b01287
Journal article

2017

ProLIF: a quantitative assay for investigating integrin cytoplasmic protein interactions and synergistic membrane effects on proteoliposomes

DOI
10.1101/209262
Preprint

Investigation of the Filamin A-Dependent Mechanisms of Tissue Factor Incorporation into Microvesicles.

Collier, M. E. W., Ettelaie, C., Goult, B. T., Maraveyas, A., & Goodall, A. H. (2017). Investigation of the Filamin A-Dependent Mechanisms of Tissue Factor Incorporation into Microvesicles.. Thrombosis and haemostasis, 117(11), 2034-2044. doi:10.1160/th17-01-0009

DOI
10.1160/th17-01-0009
Journal article

2016

Talin2-mediated traction force drives matrix degradation and cell invasion.

Qi, L., Jafari, N., Li, X., Chen, Z., Li, L., Hytönen, V. P., . . . Huang, C. (2016). Talin2-mediated traction force drives matrix degradation and cell invasion.. Journal of cell science, 129(19), 3661-3674. doi:10.1242/jcs.185959

DOI
10.1242/jcs.185959
Journal article

The mechanical response of talin.

Yao, M., Goult, B. T., Klapholz, B., Hu, X., Toseland, C. P., Guo, Y., . . . Yan, J. (2016). The mechanical response of talin.. Nature communications, 7, 11966. doi:10.1038/ncomms11966

DOI
10.1038/ncomms11966
Journal article

LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex

Zacharchenko, T., Qian, X., Goult, B. T., Jethwa, D., Almeida, T. B., Ballestrem, C., . . . Barsukov, I. L. (2016). LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex. Structure, 24(7), 1130-1141. doi:10.1016/j.str.2016.04.016

DOI
10.1016/j.str.2016.04.016
Journal article

Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions

DOI
10.1101/055210
Preprint

Mechano-Sensitive Interaction between Talin and Full-Length Vinculin

Wang, Y., Goult, B. T., Yao, M., & Yan, J. (2016). Mechano-Sensitive Interaction between Talin and Full-Length Vinculin. Biophysical Journal, 110(3), 23a. doi:10.1016/j.bpj.2015.11.187

DOI
10.1016/j.bpj.2015.11.187
Journal article

The Mechanical Properties of Talin Rod Domain

Yao, M., Goult, B. T., Sheetz, M. P., & Yan, J. (2016). The Mechanical Properties of Talin Rod Domain. Biophysical Journal, 110(3), 620a-621a. doi:10.1016/j.bpj.2015.11.3329

DOI
10.1016/j.bpj.2015.11.3329
Journal article

2015

2014

2013

Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3(Alp6).

Dhani, D. K., Goult, B. T., George, G. M., Rogerson, D. T., Bitton, D. A., Miller, C. J., . . . Tanaka, K. (2013). Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3(Alp6).. Molecular biology of the cell, 24(21), 3337-3349. doi:10.1091/mbc.e13-05-0253

DOI
10.1091/mbc.e13-05-0253
Journal article

Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation.

Goult, B. T., Xu, X. -P., Gingras, A. R., Swift, M., Patel, B., Bate, N., . . . Hanein, D. (2013). Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation.. Journal of structural biology, 184(1), 21-32. doi:10.1016/j.jsb.2013.05.014

DOI
10.1016/j.jsb.2013.05.014
Journal article

2012

A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation.

Bouaouina, M., Goult, B. T., Huet-Calderwood, C., Bate, N., Brahme, N. N., Barsukov, I. L., . . . Calderwood, D. A. (2012). A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation.. The Journal of biological chemistry, 287(10), 6979-6990. doi:10.1074/jbc.m111.330845

DOI
10.1074/jbc.m111.330845
Journal article

2011

FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors.

Calkin, A. C., Goult, B. T., Zhang, L., Fairall, L., Hong, C., Schwabe, J. W. R., & Tontonoz, P. (2011). FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors.. Proceedings of the National Academy of Sciences of the United States of America, 108(50), 20107-20112. doi:10.1073/pnas.1111589108

DOI
10.1073/pnas.1111589108
Journal article

The (1)H, (13)C and (15)N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing

Clayton, J. C., Phelan, M., Goult, B. T., Hautbergue, G. M., Wilson, S. A., & Lian, L. Y. (2011). The (1)H, (13)C and (15)N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing. BIOMOLECULAR NMR ASSIGNMENTS, 5, 7-10.

Journal article

The 1H, 13C and 15N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing.

Clayton, J. C., Phelan, M., Goult, B. T., Hautbergue, G. M., Wilson, S. A., & Lian, L. -Y. (2011). The 1H, 13C and 15N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing.. Biomolecular NMR assignments, 5(1), 7-10. doi:10.1007/s12104-010-9254-5

DOI
10.1007/s12104-010-9254-5
Journal article

2010

Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.

Kopp, P. M., Bate, N., Hansen, T. M., Brindle, N. P. J., Praekelt, U., Debrand, E., . . . Monkley, S. J. (2010). Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.. European journal of cell biology, 89(9), 661-673. doi:10.1016/j.ejcb.2010.05.003

DOI
10.1016/j.ejcb.2010.05.003
Journal article

2009

The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation.

Goult, B. T., Bouaouina, M., Harburger, D. S., Bate, N., Patel, B., Anthis, N. J., . . . Critchley, D. R. (2009). The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation.. Journal of molecular biology, 394(5), 944-956. doi:10.1016/j.jmb.2009.09.061

DOI
10.1016/j.jmb.2009.09.061
Journal article

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.

Anthis, N. J., Wegener, K. L., Ye, F., Kim, C., Goult, B. T., Lowe, E. D., . . . Campbell, I. D. (2009). The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.. The EMBO journal, 28(22), 3623-3632. doi:10.1038/emboj.2009.287

DOI
10.1038/emboj.2009.287
Journal article

2008

Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling.

Srivastava, J., Barreiro, G., Groscurth, S., Gingras, A. R., Goult, B. T., Critchley, D. R., . . . Barber, D. L. (2008). Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling.. Proceedings of the National Academy of Sciences of the United States of America, 105(38), 14436-14441. doi:10.1073/pnas.0805163105

DOI
10.1073/pnas.0805163105
Journal article

NMR assignment of the C-terminal actin-binding domain of talin.

Goult, B. T., Gingras, A. R., Bate, N., Roberts, G. C. K., Critchley, D. R., & Barsukov, I. L. (2008). NMR assignment of the C-terminal actin-binding domain of talin.. Biomolecular NMR assignments, 2(1), 17-19. doi:10.1007/s12104-007-9073-5

DOI
10.1007/s12104-007-9073-5
Journal article

The structure of the C-terminal actin-binding domain of talin

Gingras, A. R., Bate, N., Goult, B. T., Hazelwood, L., Canestrelli, I., Grossmann, J. G., . . . Critchley, D. R. (2008). The structure of the C-terminal actin-binding domain of talin. The EMBO Journal, 27(2), 458-469. doi:10.1038/sj.emboj.7601965

DOI
10.1038/sj.emboj.7601965
Journal article

2007

Small-angle X-ray scattering and NMR studies of the conformation of the PDZ region of SAP97 and its interactions with Kir2.1

Goult, B. T., Rapley, J. D., Dart, C., Kitmitto, A., Grossmann, J. G., Leyland, M. L., & Lian, L. -Y. (2007). Small-angle X-ray scattering and NMR studies of the conformation of the PDZ region of SAP97 and its interactions with Kir2.1. BIOCHEMISTRY, 46(49), 14117-14128. doi:10.1021/bi701257z

DOI
10.1021/bi701257z
Journal article

2006

Assignment of 1H, 13C, and 15N resonances for the PilP pilot protein from Neisseria meningitidis.

Golovanov, A. P., Balasingham, S., Tzitzilonis, C., Goult, B. T., Lian, L. -Y., Homberset, H., . . . Derrick, J. P. (2006). Assignment of 1H, 13C, and 15N resonances for the PilP pilot protein from Neisseria meningitidis.. Journal of biomolecular NMR, 36 Suppl 1, 68. doi:10.1007/s10858-006-9054-5

DOI
10.1007/s10858-006-9054-5
Journal article

The solution structure of a domain from the Neisseria meningitidis lipoprotein PilP reveals a new beta-sandwich fold.

Golovanov, A. P., Balasingham, S., Tzitzilonis, C., Goult, B. T., Lian, L. -Y., Homberset, H., . . . Derrick, J. P. (2006). The solution structure of a domain from the Neisseria meningitidis lipoprotein PilP reveals a new beta-sandwich fold.. Journal of molecular biology, 364(2), 186-195. doi:10.1016/j.jmb.2006.08.078

DOI
10.1016/j.jmb.2006.08.078
Journal article