Publications
Selected publications
- The structure of an Amyloid Precursor Protein/talin complex indicates a mechanical basis of Alzheimer's Disease. (Preprint - 2024)
- Mechanotransduction through protein stretching. (Journal article - 2024)
- Next-generation protein-based materials capture and preserve projectiles from supersonic impacts. (Journal article - 2023)
- The MeshCODE to scale-visualising synaptic binary information. (Journal article - 2022)
- Talin in mechanotransduction and mechanomemory at a glance. (Journal article - 2021)
- Talin rod domain-containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation. (Journal article - 2021)
- The Mechanical Basis of Memory - the MeshCODE Theory. (Journal article - 2021)
- Talin as a mechanosensitive signaling hub. (Journal article - 2018)
- The mechanical response of talin. (Journal article - 2016)
- TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity. (Journal article - 2023)
2024
Talin-1 variants associated with spontaneous coronary artery dissection (SCAD) highlight how even subtle changes in multi-functional scaffold proteins can manifest in disease.
Azizi, L., Otani, Y., Mykuliak, V. V., Goult, B. T., Hytönen, V. P., & Turkki, P. (2024). Talin-1 variants associated with spontaneous coronary artery dissection (SCAD) highlight how even subtle changes in multi-functional scaffold proteins can manifest in disease.. Human molecular genetics, 33(21), 1846-1857. doi:10.1093/hmg/ddae120
Proteomic profiling identifies a direct interaction between heat shock transcription factor 2 and the focal adhesion adapter talin‐1
Da Silva, A. J., Hästbacka, H. S. E., Luoto, J. C., Gough, R. E., Coelho‐Rato, L. S., Laitala, L. M., . . . Henriksson, E. (2024). Proteomic profiling identifies a direct interaction between heat shock transcription factor 2 and the focal adhesion adapter talin‐1. The FEBS Journal. doi:10.1111/febs.17271
TLNRD1 is a CCM complex component and regulates endothelial barrier integrity.
Ball, N. J., Ghimire, S., Follain, G., Pajari, A. O., Wurzinger, D., Vaitkevičiūtė, M., . . . Jacquemet, G. (2024). TLNRD1 is a CCM complex component and regulates endothelial barrier integrity.. The Journal of cell biology, 223(9), e202310030. doi:10.1083/jcb.202310030
Cellular stiffness sensing through talin 1 in tissue mechanical homeostasis.
Chanduri, M., Kumar, A., Weiss, D., Emuna, N., Barsukov, I., Shi, M., . . . Schwartz, M. A. (2024). Cellular stiffness sensing through talin 1 in tissue mechanical homeostasis.. Sci Adv, 10(34), eadi6286. doi:10.1126/sciadv.adi6286
Molecular dynamics simulations reveal how vinculin refolds partially unfolded talin rod helices to stabilize them against mechanical force
Mykuliak, V. V., Rahikainen, R., Ball, N. J., Bussi, G., Goult, B. T., & Hytönen, V. P. (n.d.). Molecular dynamics simulations reveal how vinculin refolds partially unfolded talin rod helices to stabilize them against mechanical force. PLOS Computational Biology, 20(8), e1012341. doi:10.1371/journal.pcbi.1012341
Alternative molecular mechanisms for force transmission at adherens junctions via β-catenin-vinculin interaction.
Morales-Camilo, N., Liu, J., Ramírez, M. J., Canales-Salgado, P., Alegría, J. J., Liu, X., . . . Bertocchi, C. (2024). Alternative molecular mechanisms for force transmission at adherens junctions via β-catenin-vinculin interaction.. Nature communications, 15(1), 5608. doi:10.1038/s41467-024-49850-5
The actin binding sites of talin have both distinct and complementary roles in cell-ECM adhesion.
Camp, D., Venkatesh, B., Solianova, V., Varela, L., Goult, B. T., & Tanentzapf, G. (2024). The actin binding sites of talin have both distinct and complementary roles in cell-ECM adhesion.. PLoS genetics, 20(4), e1011224. doi:10.1371/journal.pgen.1011224
Mechanically operated signalling scaffolds.
Ball, N. J., Barnett, S. F. H., & Goult, B. T. (2024). Mechanically operated signalling scaffolds.. Biochemical Society transactions, BST20221194. doi:10.1042/bst20221194
The focal adhesion protein talin is a mechanically gated A-kinase anchoring protein.
Kang, M., Otani, Y., Guo, Y., Yan, J., Goult, B. T., & Howe, A. K. (2024). The focal adhesion protein talin is a mechanically gated A-kinase anchoring protein.. Proceedings of the National Academy of Sciences of the United States of America, 121(13), e2314947121. doi:10.1073/pnas.2314947121
Mechanotransduction through protein stretching.
Guo, Y., Yan, J., & Goult, B. T. (2024). Mechanotransduction through protein stretching.. Current opinion in cell biology, 87, 102327. doi:10.1016/j.ceb.2024.102327
2023
3D matrix adhesion feedback controls nuclear force coupling to drive invasive cell migration.
Newman, D., Young, L. E., Waring, T., Brown, L., Wolanska, K. I., MacDonald, E., . . . Zech, T. (2023). 3D matrix adhesion feedback controls nuclear force coupling to drive invasive cell migration.. Cell reports, 42(12), 113554. doi:10.1016/j.celrep.2023.113554
Force-dependent focal adhesion assembly and disassembly: A computational study.
Honasoge, K. S., Karagöz, Z., Goult, B. T., Wolfenson, H., LaPointe, V. L. S., & Carlier, A. (2023). Force-dependent focal adhesion assembly and disassembly: A computational study.. PLoS computational biology, 19(10), e1011500. doi:10.1371/journal.pcbi.1011500
Next-generation protein-based materials capture and preserve projectiles from supersonic impacts.
Doolan, J. A., Alesbrook, L. S., Baker, K., Brown, I. R., Williams, G. T., Hilton, K. L. F., . . . Goult, B. T. (2023). Next-generation protein-based materials capture and preserve projectiles from supersonic impacts.. Nature nanotechnology, 18(9), 1060-1066. doi:10.1038/s41565-023-01431-1
Clutching at Guidance Cues: The Integrin-FAK Axis Steers Axon Outgrowth.
Davis-Lunn, M., Goult, B. T., & Andrews, M. R. (2023). Clutching at Guidance Cues: The Integrin-FAK Axis Steers Axon Outgrowth.. Biology, 12(7), 954. doi:10.3390/biology12070954
The structural basis of the talin-KANK1 interaction that coordinates the actin and microtubule cytoskeletons at focal adhesions.
Li, X., Goult, B. T., Ballestrem, C., & Zacharchenko, T. (2023). The structural basis of the talin-KANK1 interaction that coordinates the actin and microtubule cytoskeletons at focal adhesions.. Open biology, 13(6), 230058. doi:10.1098/rsob.230058
TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity.
Gallego-Paez, L. M., Edwards, W. J. S., Chanduri, M., Guo, Y., Koorman, T., Lee, C. -Y., . . . Goult, B. T. (2023). TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity.. The Journal of cell biology, 222(5), e202209010. doi:10.1083/jcb.202209010
Myosin-X recruits lamellipodin to filopodia tips.
Popović, A., Miihkinen, M., Ghimire, S., Saup, R., Grönloh, M. L. B., Ball, N. J., . . . Jacquemet, G. (2023). Myosin-X recruits lamellipodin to filopodia tips.. Journal of cell science, 136(5), jcs260574. doi:10.1242/jcs.260574
Editorial: Integrin adhesion receptors in health and disease.
Kostourou, V., Goult, B. T., & Ambriović-Ristov, A. (2023). Editorial: Integrin adhesion receptors in health and disease.. Frontiers in cell and developmental biology, 11, 1149920. doi:10.3389/fcell.2023.1149920
2022
Talin variant P229S compromises integrin activation and associates with multifaceted clinical symptoms.
Azizi, L., Varela, L., Turkki, P., Mykuliak, V. V., Korpela, S., Ihalainen, T. O., . . . Goult, B. T. (2022). Talin variant P229S compromises integrin activation and associates with multifaceted clinical symptoms.. Human molecular genetics, 31(24), 4159-4172. doi:10.1093/hmg/ddac163
The MeshCODE to scale-visualising synaptic binary information.
Barnett, S. F. H., & Goult, B. T. (2022). The MeshCODE to scale-visualising synaptic binary information.. Frontiers in cellular neuroscience, 16, 1014629. doi:10.3389/fncel.2022.1014629
The mechanical cell - the role of force dependencies in synchronising protein interaction networks.
Goult, B. T., von Essen, M., & Hytönen, V. P. (2022). The mechanical cell - the role of force dependencies in synchronising protein interaction networks.. Journal of cell science, 135(22), jcs259769. doi:10.1242/jcs.259769
Talin1 dysfunction is genetically linked to systemic capillary leak syndrome
Advancements in antimicrobial nanoscale materials and self-assembling systems.
Doolan, J. A., Williams, G. T., Hilton, K. L. F., Chaudhari, R., Fossey, J. S., Goult, B. T., & Hiscock, J. R. (2022). Advancements in antimicrobial nanoscale materials and self-assembling systems.. Chemical Society reviews, 51(20), 8696-8755. doi:10.1039/d1cs00915j
Structural Basis of β2 Integrin Inside-Out Activation.
Wen, L., Lyu, Q., Ley, K., & Goult, B. T. (2022). Structural Basis of β2 Integrin Inside-Out Activation.. Cells, 11(19), 3039. doi:10.3390/cells11193039
A novel cancer-associated cassette exon in <i>TLN1</i> alters Talin 1 mechanosensitivity
2021
Talin in mechanotransduction and mechanomemory at a glance.
Goult, B. T., Brown, N. H., & Schwartz, M. A. (2021). Talin in mechanotransduction and mechanomemory at a glance.. Journal of cell science, 134(20), jcs258749. doi:10.1242/jcs.258749
Force-Dependent Interactions between Talin and Full-Length Vinculin.
Wang, Y., Yao, M., Baker, K. B., Gough, R. E., Le, S., Goult, B. T., & Yan, J. (2021). Force-Dependent Interactions between Talin and Full-Length Vinculin.. Journal of the American Chemical Society, 143(36), 14726-14737. doi:10.1021/jacs.1c06223
Myosin-X and talin modulate integrin activity at filopodia tips.
Miihkinen, M., Grönloh, M. L. B., Popović, A., Vihinen, H., Jokitalo, E., Goult, B. T., . . . Jacquemet, G. (2021). Myosin-X and talin modulate integrin activity at filopodia tips.. Cell reports, 36(11), 109716. doi:10.1016/j.celrep.2021.109716
Talin rod domain-containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation.
Cowell, A. R., Jacquemet, G., Singh, A. K., Varela, L., Nylund, A. S., Ammon, Y. -C., . . . Goult, B. T. (2021). Talin rod domain-containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation.. The Journal of cell biology, 220(9), e202005214. doi:10.1083/jcb.202005214
Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1.
Gough, R. E., Jones, M. C., Zacharchenko, T., Le, S., Yu, M., Jacquemet, G., . . . Goult, B. T. (2021). Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1.. The Journal of biological chemistry, 297(1), 100837. doi:10.1016/j.jbc.2021.100837
Pre-complexation of talin and vinculin without tension is required for efficient nascent adhesion maturation.
Han, S. J., Azarova, E. V., Whitewood, A. J., Bachir, A., Guttierrez, E., Groisman, A., . . . Danuser, G. (2021). Pre-complexation of talin and vinculin without tension is required for efficient nascent adhesion maturation.. eLife, 10, e66151. doi:10.7554/elife.66151
Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1
The Mechanical Basis of Memory - the MeshCODE Theory.
Goult, B. T. (2021). The Mechanical Basis of Memory - the MeshCODE Theory.. Frontiers in molecular neuroscience, 14, 592951. doi:10.3389/fnmol.2021.592951
Cancer associated talin point mutations disorganise cell adhesion and migration.
Azizi, L., Cowell, A. R., Mykuliak, V. V., Goult, B. T., Turkki, P., & Hytönen, V. P. (2021). Cancer associated talin point mutations disorganise cell adhesion and migration.. Scientific reports, 11(1), 347. doi:10.1038/s41598-020-77911-4
Biochemical Characterization of the Integrin Interactome.
Khan, R. B., Varela, L., Cowell, A. R., & Goult, B. T. (2021). Biochemical Characterization of the Integrin Interactome.. Methods in molecular biology (Clifton, N.J.), 2217, 115-147. doi:10.1007/978-1-0716-0962-0_9
2020
<strong>The Mechanical Basis of Memory - the MeshCODE Theory</strong>
<strong>The Mechanical Basis of Memory - the MeshCODE Theory</strong>
Myosin-X and talin modulate integrin activity at filopodia tips
2019
Adhesions Assemble!-Autoinhibition as a Major Regulatory Mechanism of Integrin-Mediated Adhesion.
Khan, R. B., & Goult, B. T. (2019). Adhesions Assemble!-Autoinhibition as a Major Regulatory Mechanism of Integrin-Mediated Adhesion.. Frontiers in molecular biosciences, 6, 144. doi:10.3389/fmolb.2019.00144
High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained.
Bryce, N. S., Failes, T. W., Stehn, J. R., Baker, K., Zahler, S., Arzhaeva, Y., . . . Lock, J. G. (2019). High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained.. Cell systems, 9(5), 496-507.e5. doi:10.1016/j.cels.2019.09.002
Force-Dependent Binding Constants.
Wang, Y., Yan, J., & Goult, B. T. (2019). Force-Dependent Binding Constants.. Biochemistry, 58(47), 4696-4709. doi:10.1021/acs.biochem.9b00453
Force-Dependent Regulation of Talin-KANK1 Complex at Focal Adhesions.
Yu, M., Le, S., Ammon, Y. -C., Goult, B. T., Akhmanova, A., & Yan, J. (2019). Force-Dependent Regulation of Talin-KANK1 Complex at Focal Adhesions.. Nano letters, 19(9), 5982-5990. doi:10.1021/acs.nanolett.9b01732
Kindlin-1 Regulates Epidermal Growth Factor Receptor Signaling.
Michael, M., Begum, R., Chan, G. K., Whitewood, A. J., Matthews, D. R., Goult, B. T., . . . Parsons, M. (2019). Kindlin-1 Regulates Epidermal Growth Factor Receptor Signaling.. The Journal of investigative dermatology, 139(2), 369-379. doi:10.1016/j.jid.2018.08.020
Calcium-mediated Protein Folding and Stabilization of Salmonella Biofilm-associated Protein A.
Guttula, D., Yao, M., Baker, K., Yang, L., Goult, B. T., Doyle, P. S., & Yan, J. (2019). Calcium-mediated Protein Folding and Stabilization of Salmonella Biofilm-associated Protein A.. Journal of molecular biology, 431(2), 433-443. doi:10.1016/j.jmb.2018.11.014
2018
Direct binding of Talin to Rap1 is required for cell-ECM adhesion in <i>Drosophila</i>.
Camp, D., Haage, A., Solianova, V., Castle, W. M., Xu, Q. A., Lostchuck, E., . . . Tanentzapf, G. (2018). Direct binding of Talin to Rap1 is required for cell-ECM adhesion in <i>Drosophila</i>.. Journal of cell science, 131(24), jcs225144. doi:10.1242/jcs.225144
Talin Autoinhibition Regulates Cell-ECM Adhesion Dynamics and Wound Healing In Vivo.
Haage, A., Goodwin, K., Whitewood, A., Camp, D., Bogutz, A., Turner, C. T., . . . Tanentzapf, G. (2018). Talin Autoinhibition Regulates Cell-ECM Adhesion Dynamics and Wound Healing In Vivo.. Cell reports, 25(9), 2401-2416.e5. doi:10.1016/j.celrep.2018.10.098
Talin as a mechanosensitive signaling hub.
Goult, B. T., Yan, J., & Schwartz, M. A. (2018). Talin as a mechanosensitive signaling hub.. The Journal of cell biology, 217(11), 3776-3784. doi:10.1083/jcb.201808061
Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation.
Lagarrigue, F., Gingras, A. R., Paul, D. S., Valadez, A. J., Cuevas, M. N., Sun, H., . . . Ginsberg, M. H. (2018). Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation.. Blood advances, 2(18), 2358-2368. doi:10.1182/bloodadvances.2018020487
ProLIF - quantitative integrin protein-protein interactions and synergistic membrane effects on proteoliposomes.
De Franceschi, N., Miihkinen, M., Hamidi, H., Alanko, J., Mai, A., Picas, L., . . . Ivaska, J. (2018). ProLIF - quantitative integrin protein-protein interactions and synergistic membrane effects on proteoliposomes.. Journal of cell science, 132(4), jcs214270. doi:10.1242/jcs.214270
The tale of two talins - two isoforms to fine-tune integrin signalling.
Gough, R. E., & Goult, B. T. (2018). The tale of two talins - two isoforms to fine-tune integrin signalling.. FEBS letters, 592(12), 2108-2125. doi:10.1002/1873-3468.13081
A Novel Mechanism for Calmodulin-Dependent Inactivation of Transient Receptor Potential Vanilloid 6.
Bate, N., Caves, R. E., Skinner, S. P., Goult, B. T., Basran, J., Mitcheson, J. S., & Vuister, G. W. (2018). A Novel Mechanism for Calmodulin-Dependent Inactivation of Transient Receptor Potential Vanilloid 6.. Biochemistry, 57(18), 2611-2622. doi:10.1021/acs.biochem.7b01286
The Structural Basis of Calcium-Dependent Inactivation of the Transient Receptor Potential Vanilloid 5 Channel.
Bokhovchuk, F. M., Bate, N., Kovalevskaya, N. V., Goult, B. T., Spronk, C. A. E. M., & Vuister, G. W. (2018). The Structural Basis of Calcium-Dependent Inactivation of the Transient Receptor Potential Vanilloid 5 Channel.. Biochemistry, 57(18), 2623-2635. doi:10.1021/acs.biochem.7b01287
Chlamydial virulence factor TarP mimics talin to disrupt the talin-vinculin complex.
Whitewood, A. J., Singh, A. K., Brown, D. G., & Goult, B. T. (2018). Chlamydial virulence factor TarP mimics talin to disrupt the talin-vinculin complex.. FEBS letters, 592(10), 1751-1760. doi:10.1002/1873-3468.13074
2017
ProLIF: a quantitative assay for investigating integrin cytoplasmic protein interactions and synergistic membrane effects on proteoliposomes
Investigation of the Filamin A-Dependent Mechanisms of Tissue Factor Incorporation into Microvesicles.
Collier, M. E. W., Ettelaie, C., Goult, B. T., Maraveyas, A., & Goodall, A. H. (2017). Investigation of the Filamin A-Dependent Mechanisms of Tissue Factor Incorporation into Microvesicles.. Thrombosis and haemostasis, 117(11), 2034-2044. doi:10.1160/th17-01-0009
2016
Talin2-mediated traction force drives matrix degradation and cell invasion.
Qi, L., Jafari, N., Li, X., Chen, Z., Li, L., Hytönen, V. P., . . . Huang, C. (2016). Talin2-mediated traction force drives matrix degradation and cell invasion.. Journal of cell science, 129(19), 3661-3674. doi:10.1242/jcs.185959
Correction: Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity.
Kumar, A., Ouyang, M., Van den Dries, K., McGhee, E. J., Tanaka, K., Anderson, M. D., . . . Schwartz, M. A. (2016). Correction: Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity.. The Journal of cell biology, 214(2), 231. doi:10.1083/jcb.20151001207062016c
Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions.
Bouchet, B. P., Gough, R. E., Ammon, Y. -C., van de Willige, D., Post, H., Jacquemet, G., . . . Akhmanova, A. (2016). Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions.. eLife, 5, e18124. doi:10.7554/elife.18124
The mechanical response of talin.
Yao, M., Goult, B. T., Klapholz, B., Hu, X., Toseland, C. P., Guo, Y., . . . Yan, J. (2016). The mechanical response of talin.. Nature communications, 7, 11966. doi:10.1038/ncomms11966
LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex
Zacharchenko, T., Qian, X., Goult, B. T., Jethwa, D., Almeida, T. B., Ballestrem, C., . . . Barsukov, I. L. (2016). LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex. Structure, 24(7), 1130-1141. doi:10.1016/j.str.2016.04.016
Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions
Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity.
Kumar, A., Ouyang, M., Van den Dries, K., McGhee, E. J., Tanaka, K., Anderson, M. D., . . . Schwartz, M. A. (2016). Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity.. The Journal of cell biology, 213(3), 371-383. doi:10.1083/jcb.201510012
Mechano-Sensitive Interaction between Talin and Full-Length Vinculin
Wang, Y., Goult, B. T., Yao, M., & Yan, J. (2016). Mechano-Sensitive Interaction between Talin and Full-Length Vinculin. Biophysical Journal, 110(3), 23a. doi:10.1016/j.bpj.2015.11.187
The Mechanical Properties of Talin Rod Domain
Yao, M., Goult, B. T., Sheetz, M. P., & Yan, J. (2016). The Mechanical Properties of Talin Rod Domain. Biophysical Journal, 110(3), 620a-621a. doi:10.1016/j.bpj.2015.11.3329
2015
A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration.
Villari, G., Jayo, A., Zanet, J., Fitch, B., Serrels, B., Frame, M., . . . Parsons, M. (2015). A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration.. Journal of cell science, 128(24), 4601-4614. doi:10.1242/jcs.175760
Vinculin controls talin engagement with the actomyosin machinery.
Atherton, P., Stutchbury, B., Wang, D. -Y., Jethwa, D., Tsang, R., Meiler-Rodriguez, E., . . . Ballestrem, C. (2015). Vinculin controls talin engagement with the actomyosin machinery.. Nature communications, 6. doi:10.1038/ncomms10038
Talin Dependent Mechanosensitivity of Cell Focal Adhesions.
Yan, J., Yao, M., Goult, B. T., & Sheetz, M. P. (2015). Talin Dependent Mechanosensitivity of Cell Focal Adhesions.. Cellular and molecular bioengineering, 8(1), 151-159. doi:10.1007/s12195-014-0364-5
Structure calculation, refinement and validation using CcpNmr Analysis.
Skinner, S. P., Goult, B. T., Fogh, R. H., Boucher, W., Stevens, T. J., Laue, E. D., & Vuister, G. W. (2015). Structure calculation, refinement and validation using CcpNmr Analysis.. Acta crystallographica. Section D, Biological crystallography, 71(Pt 1), 154-161. doi:10.1107/s1399004714026662
2014
The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering.
Ellis, S. J., Lostchuck, E., Goult, B. T., Bouaouina, M., Fairchild, M. J., López-Ceballos, P., . . . Tanentzapf, G. (2014). The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering.. PLoS genetics, 10(11), e1004756. doi:10.1371/journal.pgen.1004756
Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation.
Yao, M., Goult, B. T., Chen, H., Cong, P., Sheetz, M. P., & Yan, J. (2014). Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation.. Scientific reports, 4, 4610. doi:10.1038/srep04610
The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain.
Evans, S. E., Goult, B. T., Fairall, L., Jamieson, A. G., Ko Ferrigno, P., Ford, R., . . . Wagner, S. D. (2014). The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain.. PloS one, 9(3), e90889. doi:10.1371/journal.pone.0090889
2013
Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3(Alp6).
Dhani, D. K., Goult, B. T., George, G. M., Rogerson, D. T., Bitton, D. A., Miller, C. J., . . . Tanaka, K. (2013). Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3(Alp6).. Molecular biology of the cell, 24(21), 3337-3349. doi:10.1091/mbc.e13-05-0253
Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation.
Goult, B. T., Xu, X. -P., Gingras, A. R., Swift, M., Patel, B., Bate, N., . . . Hanein, D. (2013). Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation.. Journal of structural biology, 184(1), 21-32. doi:10.1016/j.jsb.2013.05.014
Talin autoinhibition is required for morphogenesis.
Ellis, S. J., Goult, B. T., Fairchild, M. J., Harris, N. J., Long, J., Lobo, P., . . . Tanentzapf, G. (2013). Talin autoinhibition is required for morphogenesis.. Current biology : CB, 23(18), 1825-1833. doi:10.1016/j.cub.2013.07.054
A novel interaction between FRMD7 and CASK: evidence for a causal role in idiopathic infantile nystagmus.
Watkins, R. J., Patil, R., Goult, B. T., Thomas, M. G., Gottlob, I., & Shackleton, S. (2013). A novel interaction between FRMD7 and CASK: evidence for a causal role in idiopathic infantile nystagmus.. Human molecular genetics, 22(10), 2105-2118. doi:10.1093/hmg/ddt060
RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.
Goult, B. T., Zacharchenko, T., Bate, N., Tsang, R., Hey, F., Gingras, A. R., . . . Barsukov, I. L. (2013). RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.. The Journal of biological chemistry, 288(12), 8238-8249. doi:10.1074/jbc.m112.438119
2012
Subcellular localization of talin is regulated by inter-domain interactions.
Banno, A., Goult, B. T., Lee, H., Bate, N., Critchley, D. R., & Ginsberg, M. H. (2012). Subcellular localization of talin is regulated by inter-domain interactions.. The Journal of biological chemistry, 287(17), 13799-13812. doi:10.1074/jbc.m112.341214
Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics.
Bate, N., Gingras, A. R., Bachir, A., Horwitz, R., Ye, F., Patel, B., . . . Critchley, D. R. (2012). Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics.. PloS one, 7(4), e34461. doi:10.1371/journal.pone.0034461
The structure and selectivity of the SR protein SRSF2 RRM domain with RNA.
Phelan, M. M., Goult, B. T., Clayton, J. C., Hautbergue, G. M., Wilson, S. A., & Lian, L. -Y. (2012). The structure and selectivity of the SR protein SRSF2 RRM domain with RNA.. Nucleic acids research, 40(7), 3232-3244. doi:10.1093/nar/gkr1164
A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation.
Bouaouina, M., Goult, B. T., Huet-Calderwood, C., Bate, N., Brahme, N. N., Barsukov, I. L., . . . Calderwood, D. A. (2012). A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation.. The Journal of biological chemistry, 287(10), 6979-6990. doi:10.1074/jbc.m111.330845
2011
FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors.
Calkin, A. C., Goult, B. T., Zhang, L., Fairall, L., Hong, C., Schwabe, J. W. R., & Tontonoz, P. (2011). FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors.. Proceedings of the National Academy of Sciences of the United States of America, 108(50), 20107-20112. doi:10.1073/pnas.1111589108
The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.
Zhang, L., Fairall, L., Goult, B. T., Calkin, A. C., Hong, C., Millard, C. J., . . . Schwabe, J. W. R. (2011). The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.. Genes & development, 25(12), 1262-1274. doi:10.1101/gad.2056211
The (1)H, (13)C and (15)N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing
Clayton, J. C., Phelan, M., Goult, B. T., Hautbergue, G. M., Wilson, S. A., & Lian, L. Y. (2011). The (1)H, (13)C and (15)N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing. BIOMOLECULAR NMR ASSIGNMENTS, 5, 7-10.
The 1H, 13C and 15N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing.
Clayton, J. C., Phelan, M., Goult, B. T., Hautbergue, G. M., Wilson, S. A., & Lian, L. -Y. (2011). The 1H, 13C and 15N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing.. Biomolecular NMR assignments, 5(1), 7-10. doi:10.1007/s12104-010-9254-5
Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.
Oberoi, J., Fairall, L., Watson, P. J., Yang, J. -C., Czimmerer, Z., Kampmann, T., . . . Schwabe, J. W. R. (2011). Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.. Nature structural & molecular biology, 18(2), 177-184. doi:10.1038/nsmb.1983
2010
The Structure of the talin head reveals a novel extended conformation of the FERM domain.
Elliott, P. R., Goult, B. T., Kopp, P. M., Bate, N., Grossmann, J. G., Roberts, G. C. K., . . . Barsukov, I. L. (2010). The Structure of the talin head reveals a novel extended conformation of the FERM domain.. Structure (London, England : 1993), 18(10), 1289-1299. doi:10.1016/j.str.2010.07.011
The structure of the talin/integrin complex at a lipid bilayer: an NMR and MD simulation study.
Kalli, A. C., Wegener, K. L., Goult, B. T., Anthis, N. J., Campbell, I. D., & Sansom, M. S. P. (2010). The structure of the talin/integrin complex at a lipid bilayer: an NMR and MD simulation study.. Structure (London, England : 1993), 18(10), 1280-1288. doi:10.1016/j.str.2010.07.012
Central region of talin has a unique fold that binds vinculin and actin.
Gingras, A. R., Bate, N., Goult, B. T., Patel, B., Kopp, P. M., Emsley, J., . . . Critchley, D. R. (2010). Central region of talin has a unique fold that binds vinculin and actin.. The Journal of biological chemistry, 285(38), 29577-29587. doi:10.1074/jbc.m109.095455
Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.
Kopp, P. M., Bate, N., Hansen, T. M., Brindle, N. P. J., Praekelt, U., Debrand, E., . . . Monkley, S. J. (2010). Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.. European journal of cell biology, 89(9), 661-673. doi:10.1016/j.ejcb.2010.05.003
The domain structure of talin: residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site.
Goult, B. T., Gingras, A. R., Bate, N., Barsukov, I. L., Critchley, D. R., & Roberts, G. C. K. (2010). The domain structure of talin: residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site.. FEBS letters, 584(11), 2237-2241. doi:10.1016/j.febslet.2010.04.028
Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.
Goult, B. T., Bouaouina, M., Elliott, P. R., Bate, N., Patel, B., Gingras, A. R., . . . Barsukov, I. L. (2010). Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.. The EMBO journal, 29(6), 1069-1080. doi:10.1038/emboj.2010.4
2009
The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation.
Goult, B. T., Bouaouina, M., Harburger, D. S., Bate, N., Patel, B., Anthis, N. J., . . . Critchley, D. R. (2009). The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation.. Journal of molecular biology, 394(5), 944-956. doi:10.1016/j.jmb.2009.09.061
The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.
Anthis, N. J., Wegener, K. L., Ye, F., Kim, C., Goult, B. T., Lowe, E. D., . . . Campbell, I. D. (2009). The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.. The EMBO journal, 28(22), 3623-3632. doi:10.1038/emboj.2009.287
The structure of an interdomain complex that regulates talin activity.
Goult, B. T., Bate, N., Anthis, N. J., Wegener, K. L., Gingras, A. R., Patel, B., . . . Critchley, D. R. (2009). The structure of an interdomain complex that regulates talin activity.. The Journal of biological chemistry, 284(22), 15097-15106. doi:10.1074/jbc.m900078200
Structural determinants of integrin binding to the talin rod.
Gingras, A. R., Ziegler, W. H., Bobkov, A. A., Joyce, M. G., Fasci, D., Himmel, M., . . . Critchley, D. R. (2009). Structural determinants of integrin binding to the talin rod.. The Journal of biological chemistry, 284(13), 8866-8876. doi:10.1074/jbc.m805937200
2008
Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling.
Srivastava, J., Barreiro, G., Groscurth, S., Gingras, A. R., Goult, B. T., Critchley, D. R., . . . Barber, D. L. (2008). Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling.. Proceedings of the National Academy of Sciences of the United States of America, 105(38), 14436-14441. doi:10.1073/pnas.0805163105
NMR assignment of the C-terminal actin-binding domain of talin.
Goult, B. T., Gingras, A. R., Bate, N., Roberts, G. C. K., Critchley, D. R., & Barsukov, I. L. (2008). NMR assignment of the C-terminal actin-binding domain of talin.. Biomolecular NMR assignments, 2(1), 17-19. doi:10.1007/s12104-007-9073-5
The structure of the C-terminal actin-binding domain of talin
Gingras, A. R., Bate, N., Goult, B. T., Hazelwood, L., Canestrelli, I., Grossmann, J. G., . . . Critchley, D. R. (2008). The structure of the C-terminal actin-binding domain of talin. The EMBO Journal, 27(2), 458-469. doi:10.1038/sj.emboj.7601965
The structure of the C-terminal actin-binding domain of talin.
Gingras, A. R., Bate, N., Goult, B. T., Hazelwood, L., Canestrelli, I., Grossmann, J. G., . . . Critchley, D. R. (2008). The structure of the C-terminal actin-binding domain of talin.. The EMBO journal, 27(2), 458-469. doi:10.1038/sj.emboj.7601965
2007
Small-angle X-ray scattering and NMR studies of the conformation of the PDZ region of SAP97 and its interactions with Kir2.1
Goult, B. T., Rapley, J. D., Dart, C., Kitmitto, A., Grossmann, J. G., Leyland, M. L., & Lian, L. -Y. (2007). Small-angle X-ray scattering and NMR studies of the conformation of the PDZ region of SAP97 and its interactions with Kir2.1. BIOCHEMISTRY, 46(49), 14117-14128. doi:10.1021/bi701257z
2006
Assignment of 1H, 13C, and 15N resonances for the PilP pilot protein from Neisseria meningitidis.
Golovanov, A. P., Balasingham, S., Tzitzilonis, C., Goult, B. T., Lian, L. -Y., Homberset, H., . . . Derrick, J. P. (2006). Assignment of 1H, 13C, and 15N resonances for the PilP pilot protein from Neisseria meningitidis.. Journal of biomolecular NMR, 36 Suppl 1, 68. doi:10.1007/s10858-006-9054-5
The solution structure of a domain from the Neisseria meningitidis lipoprotein PilP reveals a new beta-sandwich fold.
Golovanov, A. P., Balasingham, S., Tzitzilonis, C., Goult, B. T., Lian, L. -Y., Homberset, H., . . . Derrick, J. P. (2006). The solution structure of a domain from the Neisseria meningitidis lipoprotein PilP reveals a new beta-sandwich fold.. Journal of molecular biology, 364(2), 186-195. doi:10.1016/j.jmb.2006.08.078