Publications
2024
Plug and play virus-like particles for the generation of anti-toxin antibodies.
Edge, R. J., Marriott, A. E., Stars, E. L., Patel, R. N., Wilkinson, M. C., King, L. D. W., . . . Ainsworth, S. (2024). Plug and play virus-like particles for the generation of anti-toxin antibodies.. Toxicon: X, 23, 100204. doi:10.1016/j.toxcx.2024.100204
De novo designed proteins neutralize lethal snake venom toxins.
African polyvalent antivenom can maintain pharmacological stability and ability to neutralise murine venom lethality for decades post-expiry: evidence for increasing antivenom shelf life to aid in alleviating chronic shortages.
Solano, G., Cunningham, S., Edge, R. J., Duran, G., Sanchez, A., Villalta, M., . . . Ainsworth, S. (2024). African polyvalent antivenom can maintain pharmacological stability and ability to neutralise murine venom lethality for decades post-expiry: evidence for increasing antivenom shelf life to aid in alleviating chronic shortages.. BMJ global health, 9(3), e014813. doi:10.1136/bmjgh-2023-014813
2023
ADDovenom: Thermostable Protein-Based ADDomer Nanoparticles as New Therapeutics for Snakebite Envenoming.
Menzies, S. K., Arinto-Garcia, R., Amorim, F. G., Cardoso, I. A., Abada, C., Crasset, T., . . . Schaffitzel, C. (2023). ADDovenom: Thermostable Protein-Based ADDomer Nanoparticles as New Therapeutics for Snakebite Envenoming.. Toxins, 15(12), 673. doi:10.3390/toxins15120673
OC 78.5 Systemic Snakebite Envenoming Causes Histone-Induced Thrombocytopaenia
Schofield, J., Abrams, S., Alhamdi, Y., Ainsworth, S., Evans, C., Albulescu, L., . . . Toh, C. (2023). OC 78.5 Systemic Snakebite Envenoming Causes Histone-Induced Thrombocytopaenia. Research and Practice in Thrombosis and Haemostasis, 7, 100487. doi:10.1016/j.rpth.2023.100487
2022
Two snakebite antivenoms have potential to reduce Eswatini's dependency upon a single, increasingly unavailable product: Results of preclinical efficacy testing
Menzies, S. K., Litschka-Koen, T., Edge, R. J., Alsolaiss, J., Crittenden, E., Hall, S. R., . . . Harrison, R. A. (2022). Two snakebite antivenoms have potential to reduce Eswatini's dependency upon a single, increasingly unavailable product: Results of preclinical efficacy testing. PLOS NEGLECTED TROPICAL DISEASES, 16(9). doi:10.1371/journal.pntd.0010496
Virus-like particles displaying conserved toxin epitopes stimulate polyspecific, murine antibody responses capable of snake venom recognition
Menzies, S. K., Dawson, C. A., Crittenden, E., Edge, R. J., Hall, S. R., Alsolaiss, J., . . . Ainsworth, S. (2022). Virus-like particles displaying conserved toxin epitopes stimulate polyspecific, murine antibody responses capable of snake venom recognition. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-13376-x
Exploring the Utility of Recombinant Snake Venom Serine Protease Toxins as Immunogens for Generating Experimental Snakebite Antivenoms
Alomran, N., Blundell, P., Alsolaiss, J., Crittenden, E., Ainsworth, S., Dawson, C. A., . . . Casewell, N. R. (2022). Exploring the Utility of Recombinant Snake Venom Serine Protease Toxins as Immunogens for Generating Experimental Snakebite Antivenoms. TOXINS, 14(7). doi:10.3390/toxins14070443
Exploring the utility of recombinantly expressed snake venom serine protease toxins as immunogens for generating experimental snakebite antivenoms
In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus
Menzies, S. K., Clare, R. H., Xie, C., Westhorpe, A., Hall, S. R., Edge, R. J., . . . Casewell, N. R. (2022). In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus. Toxicon: X, 14, 100118. doi:10.1016/j.toxcx.2022.100118
<i>In vitro</i> and <i>in vivo</i> venom-inhibition assays identify metalloproteinase-inhibiting drugs as potential treatments for snakebite envenoming by <i>Dispholidus typus</i>
Menzies, S. K., Clare, R. H., Xie, C., Westhorpe, A., Hall, S. R., Edge, R. J., . . . Casewell, N. R. (2022). <i>In vitro</i> and <i>in vivo</i> venom-inhibition assays identify metalloproteinase-inhibiting drugs as potential treatments for snakebite envenoming by <i>Dispholidus typus</i>. doi:10.1101/2022.01.07.475313
2021
Pro-IL-1β Is an Early Prognostic Indicator of Severe Donor Lung Injury During Ex Vivo Lung Perfusion.
Major, T., Ball, A. L., Stone, J. P., Edge, R. J., Lopez-Castejon, G., Sjöberg, T., . . . Fildes, J. E. (2021). Pro-IL-1β Is an Early Prognostic Indicator of Severe Donor Lung Injury During Ex Vivo Lung Perfusion.. Transplantation, 105(4), 768-774. doi:10.1097/tp.0000000000003463
A post-preservation vascular flush removes significant populations of donor leukocytes prior to lung transplantation.
Ball, A. L., Edge, R. J., Amin, K., Critchley, W. R., Howell, G. J., Yonan, N., . . . Fildes, J. E. (2021). A post-preservation vascular flush removes significant populations of donor leukocytes prior to lung transplantation.. Transplant immunology, 64, 101356. doi:10.1016/j.trim.2020.101356
2018
Ex-vivo flush of the limb allograft reduces inflammatory burden prior to transplantation.
Amin, K. R., Ball, A. L., Chhina, C., Edge, R. J., Stone, J. P., Critchley, W. R., . . . Fildes, J. E. (2018). Ex-vivo flush of the limb allograft reduces inflammatory burden prior to transplantation.. Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 71(2), 140-146. doi:10.1016/j.bjps.2017.11.002
2017
Characterizing the early inflammatory contribution of the donor kidney following reperfusion.
Stone, J. P., Mohamud, M., Amin, K., Critchley, W. R., Edge, R. J., Clancy, M. J., . . . Fildes, J. E. (2017). Characterizing the early inflammatory contribution of the donor kidney following reperfusion.. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 32(9), 1487-1492. doi:10.1093/ndt/gfw464
2016
<i>Ex Vivo</i> Normothermic Perfusion Induces Donor-Derived Leukocyte Mobilization and Removal Prior to Renal Transplantation.
Stone, J. P., Ball, A. L., Critchley, W. R., Major, T., Edge, R. J., Amin, K., . . . Fildes, J. E. (2016). <i>Ex Vivo</i> Normothermic Perfusion Induces Donor-Derived Leukocyte Mobilization and Removal Prior to Renal Transplantation.. Kidney international reports, 1(4), 230-239. doi:10.1016/j.ekir.2016.07.009
2014
Mild-Tourniquet Induced Ischaemia-reperfusion Injury Results in Changes to Haematological, Haemostatic and Inflammatory Parameters
Edge, R. (n.d.). Mild-Tourniquet Induced Ischaemia-reperfusion Injury Results in Changes to Haematological, Haemostatic and Inflammatory Parameters. British Journal of Medicine and Medical Research, 4(13), 2470-2482. doi:10.9734/bjmmr/2014/8387