Publications
Selected publications
- TNFR2<SUP>+</SUP> regulatory T cells protect against bacteremic pneumococcal pneumonia by suppressing IL-17A-producing y? T cells in the lung (Journal article - 2023)
- Streptococcus pneumoniae Rapidly Translocate from the Nasopharynx through the Cribriform Plate to Invade the Outer Meninges (Journal article - 2022)
- Mechanistic Insights into the Impact of Air Pollution on Pneumococcal Pathogenesis and Transmission (Journal article - 2022)
- Exposure to diesel exhaust particles increases susceptibility to invasive pneumococcal disease (Journal article - 2020)
- Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival (Journal article - 2019)
- E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells (Journal article - 2018)
- Phage therapy is highly effective against chronic lung infections with Pseudomonas aeruginosa. (Journal article - 2017)
- Airborne dust and high temperatures are risk factors for invasive bacterial disease (Journal article - 2017)
- Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice (Journal article - 2015)
- Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs. (Journal article - 2014)
2024
The <i>Streptococcus agalactiae</i> LytSR two-component regulatory system promotes vaginal colonization and virulence <i>in vivo</i>.
AlQadeeb, H., Baltazar, M., Cazares, A., Poonpanichakul, T., Kjos, M., French, N., . . . O'Brien, M. (2024). The <i>Streptococcus agalactiae</i> LytSR two-component regulatory system promotes vaginal colonization and virulence <i>in vivo</i>.. Microbiology spectrum, 12(11), e0197024. doi:10.1128/spectrum.01970-24
Galleria mellonella as an Antimicrobial Screening Model.
Barton, T. E., Duignan, L., Kadioglu, A., Fothergill, J. L., & Neill, D. R. (2024). Galleria mellonella as an Antimicrobial Screening Model.. Journal of visualized experiments : JoVE, (212). doi:10.3791/67210
Intranasal administration of DSM 32444 <i>Bacillus subtilis</i> spores: safety and tolerability.
Ho, Y. -L. T., Hynes, D., Martina, Y., Love, B., Horwell, E., Xu, R., . . . Cutting, S. M. (2024). Intranasal administration of DSM 32444 <i>Bacillus subtilis</i> spores: safety and tolerability.. Journal of medical microbiology, 73(7). doi:10.1099/jmm.0.001845
Exploiting lung adaptation and phage steering to clear pan-resistant Pseudomonas aeruginosa infections in vivo
Fothergill, J., Kadioglu, A., & Hall, J. (2024). Exploiting lung adaptation and phage steering to clear pan-resistant Pseudomonas aeruginosa infections in vivo. Nature Communications.
2023
NOVEL 3D IN VITRO HUMAN PLACENTA-ON-A-CHIP MODEL DERIVED USING HUMAN TROPHOBLAST STEM CELLS DIFFERENTIATED TOWARDS SYNCYTIOTROPHOBLASTS AND EXTRAVILLOUS TROPHOBLASTS TO MIMIC BOTH VILLI AND IMPLANTATION SIDES OF THE PLACENTA
Radziun, K., Sharp, A., Aye, I., Turner, D., Kadioglu, A., & Yang, M. (2023). NOVEL 3D IN VITRO HUMAN PLACENTA-ON-A-CHIP MODEL DERIVED USING HUMAN TROPHOBLAST STEM CELLS DIFFERENTIATED TOWARDS SYNCYTIOTROPHOBLASTS AND EXTRAVILLOUS TROPHOBLASTS TO MIMIC BOTH VILLI AND IMPLANTATION SIDES OF THE PLACENTA. In PLACENTA Vol. 140 (pp. E27-E28). Retrieved from https://www.webofscience.com/
Hypervirulent pneumococci display high levels of nasopharyngeal shedding and rapid onward transmission
TNFR2<SUP>+</SUP> regulatory T cells protect against bacteremic pneumococcal pneumonia by suppressing IL-17A-producing y? T cells in the lung
Xu, R., Jacques, L. C., Khandaker, S., Leon-Rios, M., Beentjes, D., Wei, X., . . . Kadioglu, A. (2023). TNFR2<SUP>+</SUP> regulatory T cells protect against bacteremic pneumococcal pneumonia by suppressing IL-17A-producing y? T cells in the lung. CELL REPORTS, 42(2). doi:10.1016/j.celrep.2023.112054
Influence of Streptococcus pneumoniae Within-Strain Population Diversity on Virulence and Pathogenesis
Jacques, L. C., Green, A. E., Barton, T. E., Baltazar, M., Aleksandrowicz, J., Xu, R., . . . Neill, D. R. (2022). Influence of Streptococcus pneumoniae Within-Strain Population Diversity on Virulence and Pathogenesis. MICROBIOLOGY SPECTRUM. doi:10.1128/spectrum.03103-22
2022
Pseudomonas aeruginosa utilizes the host-derived polyamine spermidine to facilitate antimicrobial tolerance
Hasan, C. M., Pottenger, S., Green, A. E., Cox, A. A., White, J. S., Jones, T., . . . Fothergill, J. L. (2022). Pseudomonas aeruginosa utilizes the host-derived polyamine spermidine to facilitate antimicrobial tolerance. JCI INSIGHT, 7(22). doi:10.1172/jci.insight.158879
Mechanistic Insights into the Impact of Air Pollution on Pneumococcal Pathogenesis and Transmission
Beentjes, D., Shears, R. K., French, N., Neill, D. R., & Kadioglu, A. (2022). Mechanistic Insights into the Impact of Air Pollution on Pneumococcal Pathogenesis and Transmission. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 206(9), 1070-1080. doi:10.1164/rccm.202112-2668TR
Streptococcus pneumoniae Rapidly Translocate from the Nasopharynx through the Cribriform Plate to Invade the Outer Meninges
Audshasai, T., Coles, J. A., Panagiotou, S., Khandaker, S., Scales, H. E., Kjos, M., . . . Yang, M. (2022). Streptococcus pneumoniae Rapidly Translocate from the Nasopharynx through the Cribriform Plate to Invade the Outer Meninges. MBIO, 13(4). doi:10.1128/mbio.01024-22
Selection of Staphylococcus aureus in a murine nasopharyngeal colonization model
Salgado, B. A. B., Waters, E. M., Moran, J. C., Kadioglu, A., & Horsburgh, M. J. (n.d.). Selection of Staphylococcus aureus in a murine nasopharyngeal colonization model. Frontiers in Cellular and Infection Microbiology, 12. doi:10.3389/fcimb.2022.874138
Serotype 1 pneumococcus: epidemiology, genomics, and disease mechanisms
Chaguza, C., Yang, M., Jacques, L. C., Bentley, S. D., & Kadioglu, A. (2022). Serotype 1 pneumococcus: epidemiology, genomics, and disease mechanisms. TRENDS IN MICROBIOLOGY, 30(6), 581-592. doi:10.1016/j.tim.2021.11.007
Structure-Based Discovery of Lipoteichoic Acid Synthase Inhibitors
Wezen, X. C., Chandran, A., Eapen, R. S., Waters, E., Bricio-Moreno, L., Tosi, T., . . . Rahman, T. (2022). Structure-Based Discovery of Lipoteichoic Acid Synthase Inhibitors. JOURNAL OF CHEMICAL INFORMATION AND MODELING, 62(10), 2586-2599. doi:10.1021/acs.jcim.2c00300
Underground railway particulate matter and susceptibility to pneumococcal infection
Miyashita, L., Shears, R., Foley, G., Semple, S., Kadioglu, A., & Grigg, J. (2022). Underground railway particulate matter and susceptibility to pneumococcal infection. EBIOMEDICINE, 80. doi:10.1016/j.ebiom.2022.104063
Comparative Genomics of Disease and Carriage Serotype 1 Pneumococci
Chaguza, C., Ebruke, C., Senghore, M., Lo, S. W., Tientcheu, P. -E., Gladstone, R. A., . . . Bentley, S. D. (2022). Comparative Genomics of Disease and Carriage Serotype 1 Pneumococci. GENOME BIOLOGY AND EVOLUTION, 14(4). doi:10.1093/gbe/evac052
Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity (vol 10, 17313, 2020)
Panagiotou, S., Chaguza, C., Yahya, R., Audshasai, T., Baltazar, M., Ressel, L., . . . Yang, M. (2022). Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity (vol 10, 17313, 2020). SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-08813-w
Underground Railway Particulate Matter and Susceptibility to Pneumococcal Infection
2021
Streptolysin O concentration and activity is central to in vivo phenotype and disease outcome in Group A Streptococcus infection
Clarke, J., Baltazar, M., Alsahag, M., Panagiotou, S., Pouget, M., Paxton, W. A., . . . Kadioglu, A. (2021). Streptolysin O concentration and activity is central to in vivo phenotype and disease outcome in Group A Streptococcus infection. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-97866-4
Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease
Law, A. E., Shears, R. K., Lopez Rodas, A. A., Grencis, R. K., Cooper, P. J., Neill, D. R., & Kadioglu, A. (2021). Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-86508-4
Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity (vol 10, 17313, 2020)
Panagiotou, S., Chaguza, C., Yahya, R., Audshasai, T., Baltazar, M., Ressel, L., . . . Yang, M. (2021). Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity (vol 10, 17313, 2020). SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-86214-1
2020
Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity
Panagiotou, S., Chaguza, C., Yahya, R., Audshasai, T., Baltazar, M., Ressel, L., . . . Yang, M. (2020). Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-73454-w
Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism
Chaguza, C., Yang, M., Cornick, J. E., du Plessis, M., Gladstone, R. A., Kwambana-Adams, B. A., . . . Bentley, S. D. (2020). Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism. COMMUNICATIONS BIOLOGY, 3(1). doi:10.1038/s42003-020-01290-9
Influenza-like illness is associated with high pneumococcal carriage density in Malawian children
Nyazika, T. K., Law, A., Swarthout, T. D., Sibale, L., ter Braake, D., French, N., . . . Neill, D. R. (2020). Influenza-like illness is associated with high pneumococcal carriage density in Malawian children. JOURNAL OF INFECTION, 81(4), 549-556. doi:10.1016/j.jinf.2020.06.079
IL-35 is critical in suppressing superantigenic <i>Staphylococcus aureus</i>-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissue
Xu, R., Shears, R. K., Sharma, R., Krishna, M., Webb, C., Ali, R., . . . Zhang, Q. (2020). IL-35 is critical in suppressing superantigenic <i>Staphylococcus aureus</i>-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissue. MUCOSAL IMMUNOLOGY, 13(3), 460-470. doi:10.1038/s41385-019-0246-1
Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin
Jacques, L. C., Panagiotou, S., Baltazar, M., Senghore, M., Khandaker, S., Xu, R., . . . Kadioglu, A. (2020). Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin. NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-15751-6
Early Signals of Vaccine-driven Perturbation Seen in Pneumococcal Carriage Population Genomic Data
Chaguza, C., Heinsbroek, E., Gladstone, R., Tafatatha, T., Alaerts, M., Peno, C., . . . Bentley, S. (2020). Early Signals of Vaccine-driven Perturbation Seen in Pneumococcal Carriage Population Genomic Data. Clinical Infectious Diseases, 70(7), 1294-1303. doi:10.1093/cid/ciz404
Exposure to diesel exhaust particles increases susceptibility to invasive pneumococcal disease
Shears, R. K., Jacques, L. C., Naylor, G., Miyashita, L., Shadia, K., Lebre, F., . . . Kadioglu, A. (2020). Exposure to diesel exhaust particles increases susceptibility to invasive pneumococcal disease. Journal of Allergy and Clinical Immunology, 145(4), 1272-1284.e6. doi:10.1016/j.jaci.2019.11.039
Impaired alanine transport or exposure to d-cycloserine increases the susceptibility of MRSA to β-lactam antibiotics.
Gallagher, L. A., Shears, R. K., Fingleton, C., Alvarez, L., Waters, E. M., Clarke, J., . . . O'Gara, J. P. (2020). Impaired alanine transport or exposure to d-cycloserine increases the susceptibility of MRSA to β-lactam antibiotics.. The Journal of infectious diseases, 221(6), 1000-1016. doi:10.1093/infdis/jiz542
2019
Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival
Subramanian, K., Neill, D. R., Malak, H., Spelmink, L., Khandaker, S., Marchiori, G., . . . Henriques-Normark, B. (2019). Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival. Nature Microbiology, 4(1), 62-70. doi:10.1038/s41564-018-0280-x
Pneumolysin interaction with the mannose receptor promotes pneumococcal invasion of the airways by blocking inflammatory responses
Subramanian, K., Neill, D. R., Malak, H. A., Spelmink, L., Khandaker, S., Marchiori, G. D. L., . . . Henriques-Normark, B. (2019). Pneumolysin interaction with the mannose receptor promotes pneumococcal invasion of the airways by blocking inflammatory responses. In SCANDINAVIAN JOURNAL OF IMMUNOLOGY Vol. 90. Retrieved from https://www.webofscience.com/
2018
Early signals of vaccine driven perturbation seen in pneumococcal carriage population genomic data
Chaguza, C., Heinsbroek, E., Gladstone, R., Tafatatha, T., Alaerts, M., Peno, C., . . . Bentley, S. (n.d.). Early signals of vaccine driven perturbation seen in pneumococcal carriage population genomic data. BioRxiv. doi:10.1101/459693
Epidemiological and Molecula Characterization of an Invasive Group A Streptococcus <i>emm</i>32.2 Outbreak (vol 55, pg 1837, 2017)
Cornick, J. E., Kiran, A. M., Vivancos, R., Van Aartsen, J., Clarke, J., Bevan, E., . . . Everett, D. B. (2018). Epidemiological and Molecula Characterization of an Invasive Group A Streptococcus <i>emm</i>32.2 Outbreak (vol 55, pg 1837, 2017). JOURNAL OF CLINICAL MICROBIOLOGY, 56(9). doi:10.1128/JCM.01001-18
Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa
Bricio-Moreno, L., Sheridan, V. H., Goodhead, I., Armstrong, S., Wong, J. K. L., Waters, E. M., . . . Neill, D. R. (2018). Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa. Nature Communications, 9. doi:10.1038/s41467-018-04996-x
Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa
Francis, V. I., Waters, E. M., Finton-James, S. E., Gori, A., Kadioglu, A., Brown, A. R., & Porter, S. L. (2018). Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa. NATURE COMMUNICATIONS, 9. doi:10.1038/s41467-018-04640-8
Erratum for Graham-Brown et al., “Dairy Heifers Naturally Exposed to Fasciola hepatica Develop a Type 2 Immune Response and Concomitant Suppression of Leukocyte Proliferation”
Graham-Brown, J., Hartley, C., Clough, H., Kadioglu, A., Baylis, M., & Williams, D. J. L. (2018). Erratum for Graham-Brown et al., “Dairy Heifers Naturally Exposed to Fasciola hepatica Develop a Type 2 Immune Response and Concomitant Suppression of Leukocyte Proliferation”. Infection and Immunity, 86(6). doi:10.1128/IAI.00247-18
E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells
Miyashita, L., Suri, R., Dearing, E., Mudway, I., Dove, R. E., Neill, D. R., . . . Grigg, J. (2018). E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells. EUROPEAN RESPIRATORY JOURNAL, 51(02), 10 pages. doi:10.1183/13993003.01592-2017
Dairy heifers naturally exposed to Fasciola hepatica develop a type-2 immune response and concomitant suppression of leukocyte proliferation.
Graham-Brown, J., Hartley, C., Clough, H., Kadioglu, A., Baylis, M., & Williams, D. J. L. (2018). Dairy heifers naturally exposed to Fasciola hepatica develop a type-2 immune response and concomitant suppression of leukocyte proliferation.. Infection and Immunity, 86(1). doi:10.1128/iai.00607-17
2017
Comparative genomic analysis and in vivo modelling of Streptococcus pneumoniae ST3081 and ST618 isolates reveal key genetic and phenotypic differences contributing to clonal replacement of serotype 1 in The Gambia.
Bricio-Moreno, L., Ebruke, C., Chaguza, C., Cornick, J., Kwambana-Adams, B., Yang, M., . . . Kadioglu, A. (2017). Comparative genomic analysis and in vivo modelling of Streptococcus pneumoniae ST3081 and ST618 isolates reveal key genetic and phenotypic differences contributing to clonal replacement of serotype 1 in The Gambia.. The Journal of infectious diseases, 216(10), 1318-1327. doi:10.1093/infdis/jix472
Population genetic structure, antibiotic resistance, capsule switching and evolution of invasive pneumococci before conjugate vaccination in Malawi
Chaguza, C., Cornick, J. E., Andam, C. P., Gladstone, R. A., Alaerts, M., Musicha, P., . . . Everett, D. B. (2017). Population genetic structure, antibiotic resistance, capsule switching and evolution of invasive pneumococci before conjugate vaccination in Malawi. VACCINE, 35(35), 4594-4602. doi:10.1016/j.vaccine.2017.07.009
Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections
Hassane, M., Demon, D., Soulard, D., Fontaine, J., Keller, L. E., Patin, E. C., . . . Paget, C. (2017). Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections. MUCOSAL IMMUNOLOGY, 10(4), 1056-1068. doi:10.1038/mi.2016.113
The accessory Sec system (SecY2A2) in <i>Streptococcus pneumoniae</i> is involved in export of pneumolysin toxin, adhesion and biofilm formation
Bandara, M., Skehel, J. M., Kadioglu, A., Collinson, I., Nobbs, A. H., Blocker, A. J., & Jenkinson, H. F. (2017). The accessory Sec system (SecY2A2) in <i>Streptococcus pneumoniae</i> is involved in export of pneumolysin toxin, adhesion and biofilm formation. MICROBES AND INFECTION, 19(7-8), 402-412. doi:10.1016/j.micinf.2017.04.003
Phage therapy is highly effective against chronic lung infections with Pseudomonas aeruginosa.
Waters, E. M., Neill, D. R., Kaman, B., Sahota, J. S., Clokie, M. R. J., Winstanley, C., & Kadioglu, A. (2017). Phage therapy is highly effective against chronic lung infections with Pseudomonas aeruginosa.. Thorax, 72, 666-667. doi:10.1136/thoraxjnl-2016-209265
Epidemiological and Molecular Characterization of an Invasive Group A Streptococcus emm32.2 Outbreak
Cornick, J. E., Kiran, A. M., Vivancos, R., Van Aartsen, J., Clarke, J., Bevan, E., . . . Everett, D. B. (n.d.). Epidemiological and Molecular Characterization of an Invasive Group A Streptococcus emm32.2 Outbreak. Journal of Clinical Microbiology, 55(6), 1837-1846. doi:10.1128/JCM.00191-17
Airborne dust and high temperatures are risk factors for invasive bacterial disease
Jusot, J. -F., Neill, D. R., Waters, E., Bangert, M., Collins, M., Bricio Moreno, L., . . . Kadioglu, A. (2017). Airborne dust and high temperatures are risk factors for invasive bacterial disease. Journal of Allergy and Clinical Immunology, 139(3), 977-986.E2. doi:10.1016/j.jaci.2016.04.062
The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1
Cornick, J. E., Bishop, O. T., Yalcin, F., Kiran, A. M., Kumwenda, B., Chaguza, C., . . . Consortium, P. (2017). The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1. VACCINE, 35(6), 972-980. doi:10.1016/j.vaccine.2016.12.037
NX-AS-401: A QUORUM SENSING INHIBITOR THAT ENHANCES THE EFFECT OF TOBRAMYCIN ON <i>P</i>. <i>AERUGINOSA</i> IN VITRO AND IN VIVO
Williams, D., Sykes, L., Bricio-Marino, L., Fothergill, J., Kadioglu, A., Oldham, H., . . . Graz, M. (2017). NX-AS-401: A QUORUM SENSING INHIBITOR THAT ENHANCES THE EFFECT OF TOBRAMYCIN ON <i>P</i>. <i>AERUGINOSA</i> IN VITRO AND IN VIVO. In PEDIATRIC PULMONOLOGY Vol. 52 (pp. S350-S351). Retrieved from https://www.webofscience.com/
Redeploying β-Lactam Antibiotics as a Novel Antivirulence Strategy for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections
Waters, E. M., Rudkin, J. K., Coughlan, S., Clair, G. C., Adkins, J. N., Gore, S., . . . O'Gara, J. P. (2017). Redeploying β-Lactam Antibiotics as a Novel Antivirulence Strategy for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections. JOURNAL OF INFECTIOUS DISEASES, 215(1), 80-87. doi:10.1093/infdis/jiw461
2016
Understanding pneumococcal serotype 1 biology through population genomic analysis
Chaguza, C., Cornick, J. E., Harris, S. R., Andam, C. P., Bricio-Moreno, L., Yang, M., . . . Bentley, S. D. (2016). Understanding pneumococcal serotype 1 biology through population genomic analysis. BMC INFECTIOUS DISEASES, 16. doi:10.1186/s12879-016-1987-z
Recombination in <i>Streptococcus pneumoniae</i> Lineages Increase with Carriage Duration and Size of the Polysaccharide Capsule
Chaguza, C., Andam, C. P., Harris, S. R., Cornick, J. E., Yang, M., Bricio-Moreno, L., . . . Hanage, W. P. (2016). Recombination in <i>Streptococcus pneumoniae</i> Lineages Increase with Carriage Duration and Size of the Polysaccharide Capsule. MBIO, 7(5). doi:10.1128/mBio.01053-16
Pneumococcal Biology, Diversity, Evolution and Host Responses to Infection
Neill, D. R., Yang, M., & Kadioglu, A. (2016). Pneumococcal Biology, Diversity, Evolution and Host Responses to Infection. In ENCYCLOPEDIA OF IMMUNOBIOLOGY, VOL 4: IMMUNITY TO PATHOGENS AND TUMORS (pp. 60-65). doi:10.1016/B978-0-12-374279-7.13019-X
Alternatives to antibiotics-a pipeline portfolio review
Czaplewski, L., Bax, R., Clokie, M., Dawson, M., Fairhead, H., Fischetti, V. A., . . . Rex, J. H. (2016). Alternatives to antibiotics-a pipeline portfolio review. LANCET INFECTIOUS DISEASES, 16(2), 239-251. doi:10.1016/S1473-3099(15)00466-1
AUGMENTED PASSIVE IMMUNOTHERAPY WITH P4 PEPTIDE IMPROVES PHAGOCYTE ACTIVITY IN SEVERE SEPSIS
Morton, B., Mitsi, E., Pennington, S. H., Reine, J., Wright, A. D., Parker, R., . . . Gordon, S. B. (2016). AUGMENTED PASSIVE IMMUNOTHERAPY WITH P4 PEPTIDE IMPROVES PHAGOCYTE ACTIVITY IN SEVERE SEPSIS. SHOCK, 46(6), 635-641. doi:10.1097/SHK.0000000000000715
2015
Bacteriophage Delivery by Nebulization and Efficacy Against Phenotypically Diverse <i>Pseudomonas aeruginosa</i> from Cystic Fibrosis Patients
Sahota, J. S., Smith, C. M., Radhakrishnan, P., Winstanley, C., Goderdzishvili, M., Chanishvili, N., . . . Clokie, M. R. J. (2015). Bacteriophage Delivery by Nebulization and Efficacy Against Phenotypically Diverse <i>Pseudomonas aeruginosa</i> from Cystic Fibrosis Patients. JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 28(5), 353-360. doi:10.1089/jamp.2014.1172
Ca²⁺-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxins.
Wolfmeier, H., Schoenauer, R., Atanassoff, A. P., Neill, D. R., Kadioglu, A., Draeger, A., & Babiychuk, E. B. (2015). Ca²⁺-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxins.. Biochimica et biophysica acta, 1853(9), 2045-2054. doi:10.1016/j.bbamcr.2014.09.005
Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection
Alhamdi, Y., Neill, D., Abrams, S., Malak, H., Yahya, R., Barrett-Jolley, R., . . . Toh, C. -H. (2015). Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection. PLoS Pathogens, 11(5). doi:10.1371/journal.ppat.1004836
Pneumolysin
Neill, D. R., Mitchell, T. J., & Kadioglu, A. (2015). Pneumolysin. In Streptococcus Pneumoniae (pp. 257-275). Elsevier. doi:10.1016/b978-0-12-410530-0.00014-4
Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K<SUP>+</SUP> Efflux
Karmakar, M., Katsnelson, M., Malak, H. A., Greene, N. G., Howell, S. J., Hise, A. G., . . . Pearlman, E. (2015). Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K<SUP>+</SUP> Efflux. JOURNAL OF IMMUNOLOGY, 194(4), 1763-1775. doi:10.4049/jimmunol.1401624
Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice
Henry, B. D., Neill, D., Becker, K. A., Gore, S., Bricio Moreno, L., Ziobro, R., . . . Babiychuk, E. B. (2015). Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice. Nature Biotechnology, 33(1), 81-88. doi:10.1038/nbt.3037
2014
Density and duration of experimental human pneumococcal carriage
Gritzfeld, J. F., Cremers, A. J. H., Ferwerda, G., Ferreira, D. M., Kadioglu, A., Hermans, P. W. M., & Gordon, S. B. (2014). Density and duration of experimental human pneumococcal carriage. CLINICAL MICROBIOLOGY AND INFECTION, 20(12), O1145-O1151. doi:10.1111/1469-0691.12752
Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs.
Fothergill, J. L., Neill, D. R., Loman, N., Winstanley, C., & Kadioglu, A. (2014). Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs.. Nature Communications, 5, 9 pages. doi:10.1038/ncomms5780
Ca<SUP>2+</SUP>-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxins
Wolfmeier, H., Schoenauer, R., Atanassoff, A. P., Neill, D. R., Kadioglu, A., Draeger, A., & Babiychuk, E. B. (2015). Ca<SUP>2+</SUP>-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxins. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1853(9), 2045-2054. doi:10.1016/j.bbamcr.2014.09.005
THE B LYMPHOCYTE DIFFERENTIATION FACTOR (BAFF) IS EXPRESSED IN THE AIRWAYS OF CHILDREN WITH CF AND IN LUNGS OF MICE INFECTED WITH PSEUDOMONAS AERUGINOSA
Neill, D. R., Saint, G. L., Bricio-Moreno, L., Fothergill, J., Southern, K. W., Winstanley, C., . . . Flanagan, B. F. (2014). THE B LYMPHOCYTE DIFFERENTIATION FACTOR (BAFF) IS EXPRESSED IN THE AIRWAYS OF CHILDREN WITH CF AND IN LUNGS OF MICE INFECTED WITH PSEUDOMONAS AERUGINOSA. PLoS One, 9(5). doi:10.1371/journal.pone.0095892.
Density and duration of pneumococcal carriage is maintained by transforming growth factor β1 and T regulatory cells.
Neill, D., Coward, W. R., Gritzfeld, J., Richards, L., Garcia-Garcia, F. J., Dotor, J., . . . Kadioglu, A. (2014). Density and duration of pneumococcal carriage is maintained by transforming growth factor β1 and T regulatory cells.. American journal of respiratory and critical care medicine, 189(10), 1250-1259. doi:10.1164/rccm.201401-0128OC
<i>Streptococcus pneumoniae</i> detects and responds to foreign bacterial peptide fragments in its environment
Hathaway, L. J., Baettig, P., Reber, S., Rotzetter, J. U., Aebi, S., Hauser, C., . . . Muehlemann, K. (2014). <i>Streptococcus pneumoniae</i> detects and responds to foreign bacterial peptide fragments in its environment. OPEN BIOLOGY, 4(4). doi:10.1098/rsob.130224
The Pneumococcal Polysaccharide Capsule and Pneumolysin Differentially Affect CXCL8 and IL-6 Release from Cells of the Upper and Lower Respiratory Tract
Kueng, E., Coward, W. R., Neill, D. R., Malak, H. A., Muehlemann, K., Kadioglu, A., . . . Hathaway, L. J. (2014). The Pneumococcal Polysaccharide Capsule and Pneumolysin Differentially Affect CXCL8 and IL-6 Release from Cells of the Upper and Lower Respiratory Tract. PLOS ONE, 9(3). doi:10.1371/journal.pone.0092355
A new protective role for S100A9 in regulation of neutrophil recruitment during invasive pneumococcal pneumonia
De Filippo, K., Neill, D. R., Mathies, M., Bangert, M., McNeill, E., Kadioglu, A., & Hogg, N. (2014). A new protective role for S100A9 in regulation of neutrophil recruitment during invasive pneumococcal pneumonia. FASEB JOURNAL, 28(8), 3600-3608. doi:10.1096/fj.13-247460
Characterisation of regulatory T cells in human nasopharynx-associated lymphoid tissue (NALT) and relationship with <i>streptococcus pneumoniae</i>
Rider, A., Vaughan, C., Upile, N., Sharma, R., Beer, H., McCormick, M., . . . Zhang, Q. (2014). Characterisation of regulatory T cells in human nasopharynx-associated lymphoid tissue (NALT) and relationship with <i>streptococcus pneumoniae</i>. IMMUNOLOGY, 143, 146. Retrieved from https://www.webofscience.com/
Elucidation of the pathogenesis of pneumococcal meningitis in a nasopharynx-to-meninges translocation mouse model
Yang, M., Engel, H., Clauzier, L., Riley, L., Pottinger, S., Cornick, J., . . . Kadioglu, A. (2014). Elucidation of the pathogenesis of pneumococcal meningitis in a nasopharynx-to-meninges translocation mouse model. IMMUNOLOGY, 143, 165. Retrieved from https://www.webofscience.com/
Septicaemia models using <i>Streptococcus pneumoniae</i> and <i>Listeria monocytogenes</i>: understanding the role of complement properdin
Dupont, A., Mohamed, F., Salehen, N., Glenn, S., Francescut, L., Adib, R., . . . Stover, C. (2014). Septicaemia models using <i>Streptococcus pneumoniae</i> and <i>Listeria monocytogenes</i>: understanding the role of complement properdin. MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 203(4), 257-271. doi:10.1007/s00430-013-0324-z
The role of the pneumococcal toxin pneumolysin during nasopharyngeal colonisation
Malak, H. A., Neill, D., & Kadioglu, A. (2014). The role of the pneumococcal toxin pneumolysin during nasopharyngeal colonisation. IMMUNOLOGY, 143, 102. Retrieved from https://www.webofscience.com/
2013
Immunoactivating Peptide P4 Augments Alveolar Macrophage Phagocytosis in Two Diverse Human Populations
Bangert, M., Wright, A. K., Rylance, J., Kelly, M. J., Wright, A. D., Carlone, G. M., . . . Gordon, S. B. (2013). Immunoactivating Peptide P4 Augments Alveolar Macrophage Phagocytosis in Two Diverse Human Populations. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 57(9), 4566-4569. doi:10.1128/AAC.00742-13
Distribution sampling and linear modelling for the analysis and validation of worm egg count methods in the diagnosis of <i>Fasciola hepatica</i>
Graham-Brown, J. J. D., Swales, H., Van, D. J., Kadioglu, A., Baylis, M., & Williams, D. J. L. (2013). Distribution sampling and linear modelling for the analysis and validation of worm egg count methods in the diagnosis of <i>Fasciola hepatica</i>. CATTLE PRACTICE, 21, 89. Retrieved from https://www.webofscience.com/
Nasopharyngeal carriage with Streptococcus pneumoniae augments the immunizing effect of pneumolysin toxoid B
Neill, D. R., Smeaton, S., Bangert, M., & Kadioglu, A. (2013). Nasopharyngeal carriage with Streptococcus pneumoniae augments the immunizing effect of pneumolysin toxoid B. Journal of Allergy and Clinical Immunology, 131(5), 1433-1435.e1. doi:10.1016/j.jaci.2012.11.004
The AgI/II Family Adhesin AspA Is Required for Respiratory Infection by <i>Streptococcus pyogenes</i>
Franklin, L., Nobbs, A. H., Bricio-Moreno, L., Wright, C. J., Maddocks, S. E., Sahota, J. S., . . . Kadioglu, A. (2013). The AgI/II Family Adhesin AspA Is Required for Respiratory Infection by <i>Streptococcus pyogenes</i>. PLOS ONE, 8(4). doi:10.1371/journal.pone.0062433
Controlled Human Infection and Rechallenge with Streptococcus pneumoniae Reveals the Protective Efficacy of Carriage in Healthy Adults
Ferreira, D. M., Neill, D. R., Bangert, M., Gritzfeld, J. F., Green, N., Wright, A. K. A., . . . Gordon, S. B. (2013). Controlled Human Infection and Rechallenge with Streptococcus pneumoniae Reveals the Protective Efficacy of Carriage in Healthy Adults. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 187(8), 855-864. doi:10.1164/rccm.201212-2277OC
<i>Spir2</i>; a novel QTL on chromosome 4 contributes to susceptibility to pneumococcal infection in mice
Wisby, L., Fernandes, V. E., Neill, D. R., Kadioglu, A., Andrew, P. W., & Denny, P. (2013). <i>Spir2</i>; a novel QTL on chromosome 4 contributes to susceptibility to pneumococcal infection in mice. BMC GENOMICS, 14. doi:10.1186/1471-2164-14-242
Experimental Human Pneumococcal Carriage
Gritzfeld, J. F., Wright, A. D., Collins, A. M., Pennington, S. H., Wright, A. K. A., Kadioglu, A., . . . Gordon, S. B. (2013). Experimental Human Pneumococcal Carriage. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (72). doi:10.3791/50115
Induction of T regulatory cells by streptococcus pneumonia
Rider, A., Mubarak, A., Derbyshire, S., McNamara, P., Kadioglu, A., & Zhang, Q. (2013). Induction of T regulatory cells by streptococcus pneumonia. In IMMUNOLOGY Vol. 140 (pp. 151). Retrieved from https://www.webofscience.com/
Nasopharyngeal carriage with <i>Streptococcus pneumoniae</i> augments the immunizing effect of pneumolysin toxoid B
Neill, D. R., Smeaton, S., Bangert, M., & Kadioglu, A. (2013). Nasopharyngeal carriage with <i>Streptococcus pneumoniae</i> augments the immunizing effect of pneumolysin toxoid B. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131(5), 1433-+. doi:10.1016/j.jaci.2012.11.004
Novel approach towards the development of vaccine candidates against pneumococcal meningitis
Yang, M., Engel, H., Chaguza, C., Cornick, J., Hathaway, L., Everett, D., & Kadioglu, A. (2013). Novel approach towards the development of vaccine candidates against pneumococcal meningitis. In IMMUNOLOGY Vol. 140 (pp. 201). Retrieved from https://www.webofscience.com/
Novel treatment for bacterial sepsis - augmented passive immunotherapy
Gore, S., Bangert, M., Rajam, G., Ades, E. W., Gordon, S. B., & Kadioglu, A. (2013). Novel treatment for bacterial sepsis - augmented passive immunotherapy. In IMMUNOLOGY Vol. 140 (pp. 201). Retrieved from https://www.webofscience.com/
TGFb and T regulatory cells mediate nasopharyngeal carriage of Streptococcus pneumoniae
Neill, D. R., Coward, W. R., Gritzfeld, J. F., Richards, L., Gordon, S. B., & Kadioglu, A. (2013). TGFb and T regulatory cells mediate nasopharyngeal carriage of Streptococcus pneumoniae. In IMMUNOLOGY Vol. 140 (pp. 101). Retrieved from https://www.webofscience.com/
2012
Nicotinamide nucleotide transhydrogenase (NNT) acts as a novel modulator of macrophage inflammatory responses
Ripoll, V. M., Meadows, N. A., Bangert, M., Lee, A. W., Kadioglu, A., & Cox, R. D. (2012). Nicotinamide nucleotide transhydrogenase (NNT) acts as a novel modulator of macrophage inflammatory responses. FASEB JOURNAL, 26(8), 3550-3562. doi:10.1096/fj.11-199935
Pneumococcal neuraminidase A: an essential upper airway colonization factor for Streptococcus pneumoniae
Brittan, J. L., Buckeridge, T. J., Finn, A., Kadioglu, A., & Jenkinson, H. F. (2012). Pneumococcal neuraminidase A: an essential upper airway colonization factor for Streptococcus pneumoniae. MOLECULAR ORAL MICROBIOLOGY, 27(4), 270-283. doi:10.1111/j.2041-1014.2012.00658.x
The Lectin Pathway of Complement Activation Is a Critical Component of the Innate Immune Response to Pneumococcal Infection
Ali, Y. M., Lynch, N. J., Haleem, K. S., Fujita, T., Endo, Y., Hansen, S., . . . Schwaeble, W. J. (2012). The Lectin Pathway of Complement Activation Is a Critical Component of the Innate Immune Response to Pneumococcal Infection. PLOS PATHOGENS, 8(7). doi:10.1371/journal.ppat.1002793
Death Is Associated with Complement C3 Depletion in Cerebrospinal Fluid of Patients with Pneumococcal Meningitis
Goonetilleke, U. R., Scarborough, M., Ward, S. A., Hussain, S., Kadioglu, A., & Gordon, S. B. (2012). Death Is Associated with Complement C3 Depletion in Cerebrospinal Fluid of Patients with Pneumococcal Meningitis. MBIO, 3(2). doi:10.1128/mBio.00272-11
Lower Density and Shorter Duration of Nasopharyngeal Carriage by Pneumococcal Serotype 1 (ST217) May Explain Its Increased Invasiveness over Other Serotypes.
Bricio-Moreno, L., Chaguza, C., Yahya, R., Shears, R. K., Cornick, J. E., Hokamp, K., . . . Kadioglu, A. (2012). Lower Density and Shorter Duration of Nasopharyngeal Carriage by Pneumococcal Serotype 1 (ST217) May Explain Its Increased Invasiveness over Other Serotypes.. mBio, 11(6). doi:10.1093/infdis/jis223
P4-Mediated Antibody Therapy in an Acute Model of Invasive Pneumococcal Disease
Bangert, M., Bricio-Moreno, L., Gore, S., Rajam, G., Ades, E. W., Gordon, S. B., & Kadioglu, A. (2012). P4-Mediated Antibody Therapy in an Acute Model of Invasive Pneumococcal Disease. JOURNAL OF INFECTIOUS DISEASES, 205(9), 1399-1407. doi:10.1093/infdis/jis223
T Regulatory Cells Control Susceptibility to Invasive Pneumococcal Pneumonia in Mice
Neill, D. R., Fernandes, V. E., Wisby, L., Haynes, A. R., Ferreira, D. M., Laher, A., . . . Andrew, P. W. (2012). T Regulatory Cells Control Susceptibility to Invasive Pneumococcal Pneumonia in Mice. PLOS PATHOGENS, 8(4). doi:10.1371/journal.ppat.1002660
Capsule Type of <i>Streptococcus pneumoniae</i> Determines Growth Phenotype
Hathaway, L. J., Brugger, S. D., Morand, B., Bangert, M., Rotzetter, J. U., Hauser, C., . . . Muehlemann, K. (2012). Capsule Type of <i>Streptococcus pneumoniae</i> Determines Growth Phenotype. PLOS PATHOGENS, 8(3). doi:10.1371/journal.ppat.1002574
Persistence of Pneumolysin in the Cerebrospinal Fluid of Patients With Pneumococcal Meningitis Is Associated With Mortality
Wall, E. C., Gordon, S. B., Hussain, S., Goonetilleke, U. R. S., Gritzfeld, J., Scarborough, M., & Kadioglu, A. (2012). Persistence of Pneumolysin in the Cerebrospinal Fluid of Patients With Pneumococcal Meningitis Is Associated With Mortality. CLINICAL INFECTIOUS DISEASES, 54(5), 701-705. doi:10.1093/cid/cir926
Absence of the lectin activation pathway of complement does not increase susceptibility to <i>Pseudomonas aeruginosa</i> infections
Kenawy, H. I., Ali, Y. M., Rajakumar, K., Lynch, N. J., Kadioglu, A., Stover, C. M., & Schwaeble, W. J. (2012). Absence of the lectin activation pathway of complement does not increase susceptibility to <i>Pseudomonas aeruginosa</i> infections. IMMUNOBIOLOGY, 217(2), 272-280. doi:10.1016/j.imbio.2011.10.001
2011
Sex-Based Differences in Susceptibility to Respiratory and Systemic Pneumococcal Disease in Mice
Kadioglu, A., Cuppone, A. M., Trappetti, C., List, T., Spreafico, A., Pozzi, G., . . . Oggioni, M. R. (2011). Sex-Based Differences in Susceptibility to Respiratory and Systemic Pneumococcal Disease in Mice. JOURNAL OF INFECTIOUS DISEASES, 204(12), 1971-1979. doi:10.1093/infdis/jir657
<i>Streptococcus pyogenes</i> antigen I/II-family polypeptide AspA shows differential ligand-binding properties and mediates biofilm formation
Maddocks, S. E., Wright, C. J., Nobbs, A. H., Brittan, J. L., Franklin, L., Stromberg, N., . . . Jenkinson, H. F. (2011). <i>Streptococcus pyogenes</i> antigen I/II-family polypeptide AspA shows differential ligand-binding properties and mediates biofilm formation. MOLECULAR MICROBIOLOGY, 81(4), 1034-1049. doi:10.1111/j.1365-2958.2011.07749.x
Gene expression in fungi
Kalkanci, A., Kadioglu, A., Wilson, D., & Jacobsen, M. D. (2011). Gene expression in fungi. IMA FUNGUS, 2(1), 29-32. doi:10.5598/imafungus.2011.02.01.05
The Integrins Mac-1 and α<sub>4</sub>β<sub>1</sub> Perform Crucial Roles in Neutrophil and T Cell Recruitment to Lungs during <i>Streptococcus pneumoniae</i> Infection
Kadioglu, A., De Filippo, K., Bangert, M., Fernandes, V. E., Richards, L., Jones, K., . . . Hogg, N. (2011). The Integrins Mac-1 and α<sub>4</sub>β<sub>1</sub> Perform Crucial Roles in Neutrophil and T Cell Recruitment to Lungs during <i>Streptococcus pneumoniae</i> Infection. JOURNAL OF IMMUNOLOGY, 186(10), 5907-5915. doi:10.4049/jimmunol.1001533
2010
Invasive <i>Streptococcus pneumoniae</i> trigger platelet activation via Toll-like receptor 2
Keane, C., Tilley, D., Cunningham, A., Smolenski, A., Kadioglu, A., Cox, D., . . . Kerrigan, S. W. (2010). Invasive <i>Streptococcus pneumoniae</i> trigger platelet activation via Toll-like receptor 2. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 8(12), 2757-2765. doi:10.1111/j.1538-7836.2010.04093.x
Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4
McNeela, E. A., Burke, A., Neill, D. R., Baxter, C., Fernandes, V. E., Ferreira, D., . . . Lavelle, E. C. (2010). Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4. PLOS PATHOGENS, 6(11). doi:10.1371/journal.ppat.1001191
A Subtype of a <i>Pseudomonas aeruginosa</i> Cystic Fibrosis Epidemic Strain Exhibits Enhanced Virulence in a Murine Model of Acute Respiratory Infection
Carter, M. E. K., Fothergill, J. L., Walshaw, M. J., Rajakumar, K., Kadioglu, A., & Winstanley, C. (2010). A Subtype of a <i>Pseudomonas aeruginosa</i> Cystic Fibrosis Epidemic Strain Exhibits Enhanced Virulence in a Murine Model of Acute Respiratory Infection. JOURNAL OF INFECTIOUS DISEASES, 202(6), 935-942. doi:10.1086/655781
Human Lung Mast Cells Mediate Pneumococcal Cell Death in Response to Activation by Pneumolysin
Cruse, G., Fernandes, V. E., de Salort, J., Pankhania, D., Marinas, M. S., Brewin, H., . . . Kadioglu, A. (2010). Human Lung Mast Cells Mediate Pneumococcal Cell Death in Response to Activation by Pneumolysin. JOURNAL OF IMMUNOLOGY, 184(12), 7108-7115. doi:10.4049/jimmunol.0900802
Pathogenicity Islands PAPI-1 and PAPI-2 Contribute Individually and Synergistically to the Virulence of <i>Pseudomonas aeruginosa</i> Strain PA14
Harrison, E. M., Carter, M. E. K., Luck, S., Ou, H. -Y., He, X., Deng, Z., . . . Rajakumar, K. (2010). Pathogenicity Islands PAPI-1 and PAPI-2 Contribute Individually and Synergistically to the Virulence of <i>Pseudomonas aeruginosa</i> Strain PA14. INFECTION AND IMMUNITY, 78(4), 1437-1446. doi:10.1128/IAI.00621-09
The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease
Richards, L., Ferreira, D. M., Miyaji, E. N., Andrew, P. W., & Kadioglu, A. (2010). The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease. IMMUNOBIOLOGY, 215(4), 251-263. doi:10.1016/j.imbio.2009.12.004
Pneumococcal protein PavA is important for nasopharyngeal carriage and development of sepsis
Kadioglu, A., Brewin, H., Haertel, T., Brittan, J. L., Klein, M., Hammerschmidt, S., & Jenkinson, H. F. (2010). Pneumococcal protein PavA is important for nasopharyngeal carriage and development of sepsis. MOLECULAR ORAL MICROBIOLOGY, 25(1), 50-60. doi:10.1111/j.2041-1014.2009.00561.x
2009
Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to <i>Streptococcus pneumoniae</i>
Ripoll, V. M., Kadioglu, A., Cox, R., Hume, D. A., & Denny, P. (2010). Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to <i>Streptococcus pneumoniae</i>. JOURNAL OF LEUKOCYTE BIOLOGY, 87(4), 735-741. doi:10.1189/jlb.0509359
Sialic Acid: A Preventable Signal for Pneumococcal Biofilm Formation, Colonization, and Invasion of the Host
Trappetti, C., Kadioglu, A., Carter, M., Hayre, J., Iannelli, F., Pozzi, G., . . . Oggioni, M. R. (2009). Sialic Acid: A Preventable Signal for Pneumococcal Biofilm Formation, Colonization, and Invasion of the Host. JOURNAL OF INFECTIOUS DISEASES, 199(10), 1497-1505. doi:10.1086/598483
2008
Increased TNF expression in CD43<SUP>++</SUP> murine blood monocytes
Burke, B., Ahmad, R., Staples, K. J., Snowden, R., Kadioglu, A., Frankenberger, M., . . . Ziegler-Heitbrock, L. (2008). Increased TNF expression in CD43<SUP>++</SUP> murine blood monocytes. IMMUNOLOGY LETTERS, 118(2), 142-147. doi:10.1016/j.imlet.2008.03.012
The role of <i>Streptococcus pneumoniae</i> virulence factors in host respiratory colonization and disease
Kadioglu, A., Weiser, J. N., Paton, J. C., & Andrew, P. W. (2008). The role of <i>Streptococcus pneumoniae</i> virulence factors in host respiratory colonization and disease. NATURE REVIEWS MICROBIOLOGY, 6(4), 288-301. doi:10.1038/nrmicro1871
The ability to utilize mucin affects the regulation of virulence gene expression in <i>Streptococcus pneumoniae</i>
Yesilkaya, H., Manco, S., Kadioglu, A., Terra, V. S., & Andrew, P. W. (2008). The ability to utilize mucin affects the regulation of virulence gene expression in <i>Streptococcus pneumoniae</i>. FEMS MICROBIOLOGY LETTERS, 278(2), 231-235. doi:10.1111/j.1574-6968.2007.01003.x
2007
MobilomeFINDER:: web-based tools for <i>in silico</i> and experimental discovery of bacterial genomic islands
Ou, H. -Y., He, X., Harrison, E. M., Kulasekara, B. R., Bin Thani, A., Kadioglu, A., . . . Rajakumar, K. (2007). MobilomeFINDER:: web-based tools for <i>in silico</i> and experimental discovery of bacterial genomic islands. NUCLEIC ACIDS RESEARCH, 35, W97-W104. doi:10.1093/nar/gkm380
2006
The cathepsin B inhibitor, z-FA-FMK, inhibits human T cell proliferation in vitro and modulates host response to pneumococcal infection in vivo
Lawrence, C. P., Kadioglu, A., Yang, A. -L., Coward, W. R., & Chow, S. C. (2006). The cathepsin B inhibitor, z-FA-FMK, inhibits human T cell proliferation in vitro and modulates host response to pneumococcal infection in vivo. JOURNAL OF IMMUNOLOGY, 177(6), 3827-3836. doi:10.4049/jimmunol.177.6.3827
Switch from planktonic to sessile life: a major event in pneumococcal pathogenesis
Oggioni, M. R., Trappetti, C., Kadioglu, A., Cassone, M., Iannelli, F., Ricci, S., . . . Pozzi, G. (2006). Switch from planktonic to sessile life: a major event in pneumococcal pathogenesis. MOLECULAR MICROBIOLOGY, 61(5), 1196-1210. doi:10.1111/j.1365-2958.2006.05310.x
Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis
Manco, S., Hernon, F., Yesilkaya, H., Paton, J. C., Andrew, P. W., & Kadioglu, A. (2006). Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis. INFECTION AND IMMUNITY, 74(7), 4014-4020. doi:10.1128/IAI.01237-05
2005
The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia
Jounblat, R., Clark, H., Eggleton, P., Hawgood, S., Andrew, P. W., & Kadioglu, A. (2005). The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia. RESPIRATORY RESEARCH, 6. doi:10.1186/1465-9921-6-126
Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts.
Kerr, A. R., Kirkham, L. A. S., Kadioglu, A., Andrew, P. W., Garside, P., Thompson, H., & Mitchell, T. J. (2005). Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts.. Microbes and infection, 7(5-6), 845-852. doi:10.1016/j.micinf.2005.02.011
Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts
Kerr, A. R., Kirkham, L. A. S., Kadioglu, A., Andrew, P. W., Garside, P., Thompson, H., & Mitchell, T. J. (2005). Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts. MICROBES AND INFECTION, 7(5-6), 845-852. doi:10.1016/j.micinf.2005.02.011
Susceptibility and resistance to pneumococcal disease in mice.
Kadioglu, A., & Andrew, P. W. (2005). Susceptibility and resistance to pneumococcal disease in mice.. Briefings in functional genomics & proteomics, 4(3), 241-247. doi:10.1093/bfgp/4.3.241
2004
The role of pneumolysin in pneumococcal pneumonia and meningitis
Hirst, R. A., Kadioglu, A., O'Callaghan, C., & Andrew, P. W. (2004). The role of pneumolysin in pneumococcal pneumonia and meningitis. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 138(2), 195-201. doi:10.1111/j.1365-2249.2004.02611.x
CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection
Kadioglu, A., Coward, W., Colston, M. J., Hewitt, C. R. A., & Andrew, P. W. (2004). CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection. INFECTION AND IMMUNITY, 72(5), 2689-2697. doi:10.1128/IAI.72.5.2689-2697.2004
Protein serine/threonine kinase StkP positively controls virulence and competence in <i>Streptococcus pneumoniae</i>
Echenique, J., Kadioglu, A., Romao, S., Andrew, P. W., & Trombe, M. C. (2004). Protein serine/threonine kinase StkP positively controls virulence and competence in <i>Streptococcus pneumoniae</i>. INFECTION AND IMMUNITY, 72(4), 2434-2437. doi:10.1128/IAI.72.4.2434-2437.2004
Binding and agglutination of <i>Streptococcus pneumoniae</i> by human surfactant protein D (SP-D) vary between strains but, SP-D fails to enhance killing by neutrophils
Jounblat, R., Kadioglu, A., Iannelli, F., Pozzi, G., Eggleton, P., & Andrew, P. W. (2004). Binding and agglutination of <i>Streptococcus pneumoniae</i> by human surfactant protein D (SP-D) vary between strains but, SP-D fails to enhance killing by neutrophils. INFECTION AND IMMUNITY, 72(2), 709-716. doi:10.1128/IAI.72.2.709-716.2004
The innate immune response to pneumococcal lung infection: the untold story
Kadioglu, A., & Andrew, P. W. (2004). The innate immune response to pneumococcal lung infection: the untold story. TRENDS IN IMMUNOLOGY, 25(3), 143-149. doi:10.1016/j.it.2003.12.006
2003
Pneumococcal Behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin (vol 71, pg 1813, 2003)
Jounblat, R., Kadioglu, A., Mitchell, T. J., & Andrew, P. W. (2003). Pneumococcal Behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin (vol 71, pg 1813, 2003). INFECTION AND IMMUNITY, 71(12), 7239. doi:10.1128/IAI.71.12.7239.2003
The MicAB two-component signaling system is involved in virulence of <i>Streptococcus pneumoniae</i>
Kadioglu, A., Echenique, J., Manco, S., Trombe, M. C., & Andrew, P. W. (2003). The MicAB two-component signaling system is involved in virulence of <i>Streptococcus pneumoniae</i>. INFECTION AND IMMUNITY, 71(11), 6676-6679. doi:10.1128/IAI.71.11.6676-6679.2003
Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the ctolytic and complement-activating activities of pneumolysin
Jounblat, R., Kadioglu, A., Mitchell, T. J., & Andrew, P. W. (2003). Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the ctolytic and complement-activating activities of pneumolysin. INFECTION AND IMMUNITY, 71(4), 1813-1819. doi:10.1128/IAI.71.4.1813-1819.2003
2002
Upper and lower respiratory tract infection by <i>Streptococcus pneumoniae</i> is affected by pneumolysin deficiency and differences in capsule type
Kadioglu, A., Taylor, S., Iannelli, F., Pozzi, G., Mitchell, T. J., & Andrew, P. W. (2002). Upper and lower respiratory tract infection by <i>Streptococcus pneumoniae</i> is affected by pneumolysin deficiency and differences in capsule type. INFECTION AND IMMUNITY, 70(6), 2886-2890. doi:10.1128/IAI.70.6.2886-2890.2002
Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection
Kerr, A. R., Irvine, J. J., Search, J. J., Gingles, N. A., Kadioglu, A., Andrew, P. W., . . . Mitchell, T. J. (2002). Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection. INFECTION AND IMMUNITY, 70(3), 1547-1557. doi:10.1128/IAI.70.3.1547-1557.2002
2001
Role of genetic resistance in invasive pneumococcal infection: Identification and study of susceptibility and resistance in inbred mouse strains
Gingles, N. A., Alexander, J. E., Kadioglu, A., Andrew, P. W., Kerr, A., Mitchell, T. J., . . . McPheat, W. L. (2001). Role of genetic resistance in invasive pneumococcal infection: Identification and study of susceptibility and resistance in inbred mouse strains. INFECTION AND IMMUNITY, 69(1), 426-434. doi:10.1128/IAI.69.1.426-434.2001
Use of green fluorescent protein in visualisation of pneumococcal invasion of broncho-epithelial cells in vivo
Kadioglu, A., Sharpe, J. A., Lazou, I., Svanborg, C., Ockleford, C., Mitchell, T. J., & Andrew, P. W. (2001). Use of green fluorescent protein in visualisation of pneumococcal invasion of broncho-epithelial cells in vivo. FEMS MICROBIOLOGY LETTERS, 194(1), 105-110. doi:10.1111/j.1574-6968.2001.tb09454.x
Use of green fluorescent protein in visualisation of pneumococcal invasion of broncho-epithelial cells in vivo
Kadioglu, A. (2001). Use of green fluorescent protein in visualisation of pneumococcal invasion of broncho-epithelial cells in vivo. FEMS Microbiology Letters, 194(1), 105-110. doi:10.1016/s0378-1097(00)00497-3
2000
Role of manganese-containing superoxide dismutase in oxidative stress and virulence of <i>Streptococcus pneumoniae</i>
Yesilkaya, H., Kadioglu, A., Gingles, N., Alexander, J. E., Mitchell, T. J., & Andrew, P. W. (2000). Role of manganese-containing superoxide dismutase in oxidative stress and virulence of <i>Streptococcus pneumoniae</i>. INFECTION AND IMMUNITY, 68(5), 2819-2826. doi:10.1128/IAI.68.5.2819-2826.2000
Host cellular immune response to pneumococcal lung infection in mice
Kadioglu, A., Gingles, N. A., Grattan, K., Kerr, A., Mitchell, T. J., & Andrew, P. W. (2000). Host cellular immune response to pneumococcal lung infection in mice. INFECTION AND IMMUNITY, 68(2), 492-501. doi:10.1128/IAI.68.2.492-501.2000
Host cellular immune response to pneumococcal lung infection in mice (vol 68, pg 492, 2000)
Kadioglu, A., Gingles, N. A., Grattan, K., Kerr, A., Mitchell, T. J., & Andrew, P. W. (2000). Host cellular immune response to pneumococcal lung infection in mice (vol 68, pg 492, 2000). INFECTION AND IMMUNITY, 68(4), 2390. doi:10.1128/IAI.68.4.2390-2390.2000
1998
Steroid pulse therapy for rheumatoid arthritis: Effect on lymphocyte subsets and mononuclear cell adhesion
Kadioglu, A., & Sheldon, P. (1998). Steroid pulse therapy for rheumatoid arthritis: Effect on lymphocyte subsets and mononuclear cell adhesion. BRITISH JOURNAL OF RHEUMATOLOGY, 37(3), 282-286. Retrieved from https://www.webofscience.com/
1996
Adhesion of rheumatoid lymphocytes to mucosal endothelium: The gut revisited
Kadioglu, A., & Sheldon, P. (1996). Adhesion of rheumatoid lymphocytes to mucosal endothelium: The gut revisited. BRITISH JOURNAL OF RHEUMATOLOGY, 35(3), 218-225. Retrieved from https://www.webofscience.com/
1995
Adherence of porcine Peyer's patch, peripheral blood and lymph node lymphocytes to Peyer's patch lamina propria
KADIOGLU, A., & SHELDON, P. (1995). Adherence of porcine Peyer's patch, peripheral blood and lymph node lymphocytes to Peyer's patch lamina propria. ADVANCES IN MUCOSAL IMMUNOLOGY, PTS A AND B, 371, 81-83. Retrieved from https://www.webofscience.com/
Adherence of rheumatoid lymphocytes to endothelium of lamina propria
KADIOGLU, A., & SHELDON, P. (1995). Adherence of rheumatoid lymphocytes to endothelium of lamina propria. ADVANCES IN MUCOSAL IMMUNOLOGY, PTS A AND B, 371, 171-173. Retrieved from https://www.webofscience.com/
1993
BSR Poster Session a
BSR Poster Session a (1993). Rheumatology, 32(suppl 1), 3-88. doi:10.1093/rheumatology/32.suppl_1.3
1992
ADHESION OF PERIPHERAL-BLOOD LYMPHOCYTES TO HIGH ENDOTHELIAL VENULES OF GUT MUCOSA - REPLY
SHELDON, P., & KADIOGLU, A. (1992). ADHESION OF PERIPHERAL-BLOOD LYMPHOCYTES TO HIGH ENDOTHELIAL VENULES OF GUT MUCOSA - REPLY. ANNALS OF THE RHEUMATIC DISEASES, 51(7), 926. doi:10.1136/ard.51.7.926-b
ADHESION OF RHEUMATOID PERIPHERAL-BLOOD AND SYNOVIAL-FLUID MONONUCLEAR-CELLS TO HIGH ENDOTHELIAL VENULES OF GUT MUCOSA
KADIOGLU, A., & SHELDON, P. (1992). ADHESION OF RHEUMATOID PERIPHERAL-BLOOD AND SYNOVIAL-FLUID MONONUCLEAR-CELLS TO HIGH ENDOTHELIAL VENULES OF GUT MUCOSA. ANNALS OF THE RHEUMATIC DISEASES, 51(1), 126-127. doi:10.1136/ard.51.1.126
Undated
Inhaled Delivery of Killed Bacillus Subtilis Spores Protects Against Acute Viral Infections Caused by Influenza, RSV and SARS-CoV-2
Xu, R., Hong, H. A., Shadia, K., Baltazar, M., Allehyani, N., Beentjes, D., . . . Kadioglu, A. (n.d.). Inhaled Delivery of Killed Bacillus Subtilis Spores Protects Against Acute Viral Infections Caused by Influenza, RSV and SARS-CoV-2.
Mutations in mexT Bypass the Stringent Response-Dependency of Virulence in Pseudomonas aeruginosa
Figueroa, W., Cazares, A., Ashworth, E., Weimann, A., Floto, R. A., Kadioglu, A., & Welch, M. (n.d.). Mutations in mexT Bypass the Stringent Response-Dependency of Virulence in Pseudomonas aeruginosa.