Research outputs
Selected research outputs
- Molecular dynamics reveals how calcium drives hetero-versus homodimerization of type I collagen (Journal article - 2026)
- Gene Expression Dysregulation in Whole Blood of Patients with Clostridioides difficile Infection (Journal article - 2024)
- Leveraging transcriptomics for precision diagnosis: Lessons learned from cancer and sepsis (Journal article - 2023)
- Blood levels of adiponectin and IL-1Ra distinguish type 3c from type 2 diabetes: Implications for earlier pancreatic cancer detection in new-onset diabetes (Journal article - 2022)
- hENT1 Predicts Benefit from Gemcitabine in Pancreatic Cancer but Only with Low CDA mRNA (Journal article - 2021)
- Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties. (Journal article - 2020)
- Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: association with diabetes mellitus (Journal article - 2016)
- Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. (Journal article - 2024)
2026
Development and external evaluation of an interpretable machine-learning model for early prediction of organ failure in higher-risk acute pancreatitis patients: A multicentre cohort study.
Wu, D., Cai, W., Chen, C., Chen, M., Lv, Y., Huang, Y., . . . Sutton, R. (2026). Development and external evaluation of an interpretable machine-learning model for early prediction of organ failure in higher-risk acute pancreatitis patients: A multicentre cohort study.. PLOS Digit Health, 5(9), e0001735. doi:10.1371/journal.pdig.0001735
Does pre-donation cardiac arrest affect post-transplant outcomes in kidney transplantation: A UK NHSBT registry data analysis
Al-Amiedy, Z., Edginton, O., Jones, A. R., Evans, A., & Goldsmith, P. (2026). Does pre-donation cardiac arrest affect post-transplant outcomes in kidney transplantation: A UK NHSBT registry data analysis. TRANSPLANTATION, 110(9S), S239. doi:10.1097/01.tp.0001250792.20679.d1
Sodium valproate induces pancreatic injury by disruption of one-carbon metabolism
Cai, W., Wu, D., Li, Y., Chvanov, M., Awais, M., Forootan, S. S., . . . Sutton, R. (2026). Sodium valproate induces pancreatic injury by disruption of one-carbon metabolism. BRITISH JOURNAL OF PHARMACOLOGY, 183(13), 3829-3848. doi:10.1111/bph.70429
Figure S1 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2026). Figure S1 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.32704532
Figure S10 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2026). Figure S10 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.32704529
Figure S11 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2026). Figure S11 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.32704526
Figure S12 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2026). Figure S12 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.32704523
Figure S2 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2026). Figure S2 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.32704520
Figure S3 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2026). Figure S3 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.32704517
Figure S4 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2026). Figure S4 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.32704511
Figure S5 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2026). Figure S5 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.32704505
Figure S6 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2026). Figure S6 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.32704499
Figure S7 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2026). Figure S7 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.32704493
Figure S8 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2026). Figure S8 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.32704490
Figure S9 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2026). Figure S9 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.32704487
Supplemental material from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2026). Supplemental material from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.32704484
Supplementary Tables 1-9 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2026). Supplementary Tables 1-9 from Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. doi:10.1158/0008-5472.32704475
NQO1 as a predictor of response to adjuvant GemCap treatment for pancreatic cancer
Williams, D., Patel, C., Murray, K., Oldfield, L., Small, B., Barrera, L. N., . . . Costello, E. (2026). NQO1 as a predictor of response to adjuvant GemCap treatment for pancreatic cancer. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 118(4), 643-654. doi:10.1093/jnci/djaf345
Usefulness of plasma bile acid profile as a prognostic biomarker for drug-induced liver injury
Monte, M. J., Tran, T. D. -B., Grove, J. I., Li, D., Stephens, C., Lucena, M. I., . . . Aithal, G. P. (2026). Usefulness of plasma bile acid profile as a prognostic biomarker for drug-induced liver injury. EBIOMEDICINE, 126, 13 pages. doi:10.1016/j.ebiom.2026.106229
Molecular dynamics reveals how calcium drives hetero-versus homodimerization of type I collagen
Johnson, E. J., Xu, S., de Souza, J. V., Evans, A., Bronowska, A. K., & Canty-Laird, E. G. (2026). Molecular dynamics reveals how calcium drives hetero-versus homodimerization of type I collagen. BIOPHYSICAL JOURNAL, 125(5), 1286-1304. doi:10.1016/j.bpj.2026.01.033
2025
Multi-biomarker panels for the identification of hepatocellular carcinoma
Elhalwagy, M., Lopes, B., Evans, A., Elsheikh, A., & Johnson, P. (2025). Multi-biomarker panels for the identification of hepatocellular carcinoma. In GUT Vol. 74 (pp. A32). doi:10.1136/gutjnl-2025-BSG.50
Prevalence of New-Onset Diabetes in Patients Undergoing Pancreatic Surgery and the Association of Glucose Dysregulation With Complications in Pancreatic Cancer.
Stott, M., Stefanova, I., Oldfield, L., Evans, A., Birch-Ford, J., Rao, R., . . . Costello, E. (2025). Prevalence of New-Onset Diabetes in Patients Undergoing Pancreatic Surgery and the Association of Glucose Dysregulation With Complications in Pancreatic Cancer.. Annals of surgery open : perspectives of surgical history, education, and clinical approaches, 6(2), e584. doi:10.1097/as9.0000000000000584
FEATURES OF THE INTESTINAL MICROBIOME FORMATION AND THE LEVEL OF INTESTINAL INFLAMMATORY RESPONSE IN NEWBORNS
Popov, S. V., Profatylo, A. O., Turner, M. A., McDonnell, E., Gutiéerrez, E. C., Evans, A., . . . Bokova, S. I. (2025). FEATURES OF THE INTESTINAL MICROBIOME FORMATION AND THE LEVEL OF INTESTINAL INFLAMMATORY RESPONSE IN NEWBORNS. Eastern Ukrainian Medical Journal, 13(1), 159-167. doi:10.21272/eumj.2025;13(1):159-167
2024
Gene Expression Dysregulation in Whole Blood of Patients with Clostridioides difficile Infection
Tsakiroglou, M., Evans, A., Doce-Carracedo, A., Little, M., Hornby, R., Roberts, P., . . . Pirmohamed, M. (2024). Gene Expression Dysregulation in Whole Blood of Patients with Clostridioides difficile Infection. International Journal of Molecular Sciences, 25(23), 12653. doi:10.3390/ijms252312653
Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis.
Bermejo-Rodriguez, C., Araos Henríquez, J., Caligiuri, G., Pinto Teles, S., Park, Y., Evans, A., . . . Perez-Mancera, P. A. (2024). Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis.. Cancer research. doi:10.1158/0008-5472.can-23-3419
2023
Leveraging transcriptomics for precision diagnosis: Lessons learned from cancer and sepsis
Tsakiroglou, M., Evans, A., & Pirmohamed, M. (2023). Leveraging transcriptomics for precision diagnosis: Lessons learned from cancer and sepsis. FRONTIERS IN GENETICS, 14, 17 pages. doi:10.3389/fgene.2023.1100352
Mutant K-Ras in Pancreatic Cancer: An Insight on the Role of Wild-Type N-Ras and K-Ras-Dependent Cell Cycle Regulation
Ferguson, R., Aughton, K., Evans, A., Shaw, V., Armstrong, J., Ware, A., . . . Greenhalf, W. (2023). Mutant K-Ras in Pancreatic Cancer: An Insight on the Role of Wild-Type N-Ras and K-Ras-Dependent Cell Cycle Regulation. CURRENT ISSUES IN MOLECULAR BIOLOGY, 45(3), 2505-2520. doi:10.3390/cimb45030164
2022
Pancreatic cancer-related diabetes mellitus: a clinical perspective
Stott, M., Oldfield, L., Evans, A., Halloran, C., & Costello, E. (2022). Pancreatic cancer-related diabetes mellitus: a clinical perspective. Pancreatology, 22, e63. doi:10.1016/j.pan.2022.06.164
Blood levels of adiponectin and IL-1Ra distinguish type 3c from type 2 diabetes: Implications for earlier pancreatic cancer detection in new-onset diabetes
Oldfield, L., Evans, A., Rao, R. G., Jenkinson, C., Purewal, T., Psarelli, E. E., . . . Costello, E. (2022). Blood levels of adiponectin and IL-1Ra distinguish type 3c from type 2 diabetes: Implications for earlier pancreatic cancer detection in new-onset diabetes. EBIOMEDICINE, 75, 13 pages. doi:10.1016/j.ebiom.2021.103802
2021
hENT1 Predicts Benefit from Gemcitabine in Pancreatic Cancer but Only with Low CDA mRNA
Aughton, K., Elander, N. O., Evans, A., Jackson, R., Campbell, F., Costello, E., . . . Greenhalf, W. (2021). hENT1 Predicts Benefit from Gemcitabine in Pancreatic Cancer but Only with Low CDA mRNA. CANCERS, 13(22), 15 pages. doi:10.3390/cancers13225758
The holding temperature of blood during a delay to processing can affect serum and plasma protein measurements
Ashworth, M., Small, B., Oldfield, L., Evans, A., Greenhalf, W., Halloran, C., & Costello, E. (2021). The holding temperature of blood during a delay to processing can affect serum and plasma protein measurements. SCIENTIFIC REPORTS, 11(1), 11 pages. doi:10.1038/s41598-021-85052-5
2020
Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties.
Barrera, L. N., Evans, A., Lane, B., Brumskill, S., Oldfield, F. E., Campbell, F., . . . Costello, E. (2020). Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties.. Cancer Research, 80(13), 2861-2873. doi:10.1158/0008-5472.can-19-3534
2019
hENT1 RNA and Protein in Combination May Act as Predictive Biomarkers for Survival for Patients Treated With Adjuvant Gemcitabine in Pancreatic Cancer
Hale, J., Evans, A., Aughton, K., Elander, N. O., Ghaneh, P., Neoptolemos, J. P., . . . Greenhalf, W. (2019). hENT1 RNA and Protein in Combination May Act as Predictive Biomarkers for Survival for Patients Treated With Adjuvant Gemcitabine in Pancreatic Cancer. In PANCREAS Vol. 48 (pp. 1436-1437). Retrieved from https://www.webofscience.com/
2018
S100A8 and S100A9 proteins form part of a paracrine feedback loop between pancreatic cancer cells and monocytes
Nedjadi, T., Evans, A., Sheikh, A., Barerra, L., Al-Ghamdi, S., Oldfield, L., . . . Costello, E. (2018). S100A8 and S100A9 proteins form part of a paracrine feedback loop between pancreatic cancer cells and monocytes. BMC CANCER, 18, 8 pages. doi:10.1186/s12885-018-5161-4
Pancreatic ductal adenocarcinoma is associated with high prevalence of pancretogenic diabetes mellitus in individuals with potentially resectable disease.
Rao, R. G., Oldfield, L., Evans, A., Greenhalf, W., Halloran, C., & Costello, E. (2018). Pancreatic ductal adenocarcinoma is associated with high prevalence of pancretogenic diabetes mellitus in individuals with potentially resectable disease.. In BRITISH JOURNAL OF SURGERY Vol. 105 (pp. 82). Retrieved from https://www.webofscience.com/
F<sub>1</sub>F<sub>0</sub>-ATP Synthase Inhibitory Factor 1 in the Normal Pancreas and in Pancreatic Ductal Adenocarcinoma: Effects on Bioenergetics, Invasion and Proliferation
Tanton, H., Voronina, S., Evans, A., Armstrong, J., Sutton, R., Criddle, D. N., . . . Tepikin, A. V. (2018). F<sub>1</sub>F<sub>0</sub>-ATP Synthase Inhibitory Factor 1 in the Normal Pancreas and in Pancreatic Ductal Adenocarcinoma: Effects on Bioenergetics, Invasion and Proliferation. FRONTIERS IN PHYSIOLOGY, 9, 13 pages. doi:10.3389/fphys.2018.00833
2017
The Prevalence of Diabetes Mellitus is Significantly Higher for Patients Undergoing Surgery for Pancreatic Ductal Adenocarcinoma Compared to Surgery for Other Pancreatic Pathologies
Rao, R. G., Costello, E., Halloran, C. M., Oldfield, L., Greenhalf, W., Ghaneh, P., . . . Mann, K. (2017). The Prevalence of Diabetes Mellitus is Significantly Higher for Patients Undergoing Surgery for Pancreatic Ductal Adenocarcinoma Compared to Surgery for Other Pancreatic Pathologies. In PANCREAS Vol. 46 (pp. 1403-1404). Retrieved from https://www.webofscience.com/
Vandetanib plus gemcitabine versus placebo plus gemcitabine in locally advanced or metastatic pancreatic carcinoma (ViP): a prospective, randomised, double-blind, multicentre phase 2 trial
Middleton, G., Palmer, D. H., Greenhalf, W., Ghaneh, P., Jackson, R., Cox, T., . . . Neoptolemos, J. P. (2017). Vandetanib plus gemcitabine versus placebo plus gemcitabine in locally advanced or metastatic pancreatic carcinoma (ViP): a prospective, randomised, double-blind, multicentre phase 2 trial. The Lancet Oncology, 18(4), 486-499. doi:10.1016/S1470-2045(17)30084-0
2016
Combined analysis of cytidine deaminase mRNA transcript expression with hENT1 protein expression on tissue microarrays from the ESPAC-3 trial helps predict patient survival with gemcitabine treatment
Aughton, K., Elander, N., Palmer, D., Cox, T., Campbell, F., Garner, E., . . . Greenhalf, W. (2016). Combined analysis of cytidine deaminase mRNA transcript expression with hENT1 protein expression on tissue microarrays from the ESPAC-3 trial helps predict patient survival with gemcitabine treatment. Pancreatology, 16(3), s30. doi:10.1016/j.pan.2016.05.104
Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: association with diabetes mellitus
Jenkinson, C., Elliott, V., Evans, A., Oldfield, L., Jenkins, R., O'Brien, D., . . . Costello-Goldring, E. (2016). Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: association with diabetes mellitus. Clinical Cancer Research, 22(7), 1734-1743. doi:10.1158/1078-0432.ccr-15-0879
2015
Decreased Serum Thrombospondin-1 Levels in Pancreatic Ductal Adenocarcinoma Patients: An Early Indicator of Cancer or Diabetes Development?
Jenkinson, C., Elliott, V. L., Evans, A., Oldfield, L., Timms, J. F., Gentry-Maharaj, A., . . . Costello, E. (2015). Decreased Serum Thrombospondin-1 Levels in Pancreatic Ductal Adenocarcinoma Patients: An Early Indicator of Cancer or Diabetes Development?. In PANCREAS Vol. 44 (pp. 1383). Retrieved from https://www.webofscience.com/
2013
iTRAQ Reveals a Serum Marker Significantly Altered in Patients up to 24 Months Prior to Diagnosis With Pancreatic Cancer
Jenkinson, C., Elliott, V., O'Brien, D., Evans, A., Sutton, R., Lane, B., . . . Costello, E. (2013). iTRAQ Reveals a Serum Marker Significantly Altered in Patients up to 24 Months Prior to Diagnosis With Pancreatic Cancer. In PANCREAS Vol. 42 (pp. 1356-1357). Retrieved from https://www.webofscience.com/
2012
The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion
Evans, A., & Costello, E. (2012). The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion. FRONTIERS IN PHYSIOLOGY, 3, 7 pages. doi:10.3389/fphys.2012.00270