Publications
Selected publications
- Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution (Journal article - 2017)
- Genome-wide associations for birth weight and correlations with adult disease (Journal article - 2016)
- Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity (Journal article - 2016)
- Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci (Journal article - 2015)
- Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. (Journal article - 2014)
2022
Identification of genetic effects underlying type 2 diabetes in South Asian and European populations
Loh, M., Zhang, W., Ng, H. K., Schmid, K., Lamri, A., Tong, L., . . . Chambers, J. C. (2022). Identification of genetic effects underlying type 2 diabetes in South Asian and European populations. COMMUNICATIONS BIOLOGY, 5(1). doi:10.1038/s42003-022-03248-5
2021
Variation in the <i>SERPINA6/SERPINA1</i> locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease
Crawford, A. A., Bankier, S., Altmaier, E., Barnes, C. L. K., Clark, D. W., Ermel, R., . . . Walker, B. R. (2021). Variation in the <i>SERPINA6/SERPINA1</i> locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease. JOURNAL OF HUMAN GENETICS, 66(6), 625-636. doi:10.1038/s10038-020-00895-6
2020
Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis
Allen, R. J., Guillen-Guio, B., Oldham, J. M., Ma, S. -F., Dressen, A., Paynton, M. L., . . . Wain, L. V. (2020). Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 201(5), 564-574. doi:10.1164/rccm.201905-1017OC
2019
Genome-wide association study of type 2 diabetes in Africa
Chen, J., Sun, M., Adeyemo, A., Pirie, F., Carstensen, T., Pomilla, C., . . . Motala, A. A. (2019). Genome-wide association study of type 2 diabetes in Africa. DIABETOLOGIA, 62(7), 1204-1211. doi:10.1007/s00125-019-4880-7
Shared genetic risk factors across carbamazepine-induced hypersensitivity reactions.
Nicoletti, P., Barrett, S., McEvoy, L., Daly, A. K., Aithal, G., Lucena, M. I., . . . Pirmohamed, M. (2019). Shared genetic risk factors across carbamazepine-induced hypersensitivity reactions.. Clinical pharmacology and therapeutics, 106(5), 1028-1036. doi:10.1002/cpt.1493
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Warrington, N. M., Beaumont, R. N., Horikoshi, M., Day, F. R., Helgeland, O., Laurin, C., . . . Freathy, R. M. (2019). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. NATURE GENETICS, 51(5), 804-+. doi:10.1038/s41588-019-0403-1
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
Bentley, A. R., Sung, Y. J., Brown, M. R., Winkler, T. W., Kraja, A. T., Ntalla, I., . . . Cupples, L. A. (2019). Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. NATURE GENETICS, 51(4), 636-+. doi:10.1038/s41588-019-0378-y
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Shrine, N., Guyatt, A. L., Erzurumluoglu, A. M., Jackson, V. E., Hobbs, B. D., Melbourne, C. A., . . . Wain, L. V. (2019). New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. NATURE GENETICS, 51(3), 481-+. doi:10.1038/s41588-018-0321-7
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.
Justice, A. E., Karaderi, T., Highland, H. M., Young, K. L., Graff, M., Lu, Y., . . . Lindgren, C. M. (2019). Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.. Nature genetics. doi:10.1038/s41588-018-0334-2
Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
Gialluisi, A., Andlauer, T. F. M., Mirza-Schreiber, N., Moll, K., Becker, J., Hoffmann, P., . . . Schulte-Koerne, G. (2019). Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia. TRANSLATIONAL PSYCHIATRY, 9. doi:10.1038/s41398-019-0402-0
Disentangling the genetics of lean mass.
Karasik, D., Zillikens, M. C., Hsu, Y. -H., Aghdassi, A., Akesson, K., Amin, N., . . . Ohlsson, C. (2019). Disentangling the genetics of lean mass.. The American journal of clinical nutrition. doi:10.1093/ajcn/nqy272
Common Genetic Variation in Relation to Brachial Vascular Dimensions and Flow-Mediated Vasodilation
Doerr, M., Hamburg, N. M., Mueller, C., Smith, N. L., Gustafsson, S., Lehtimaeki, T., . . . Schnabel, R. B. (2019). Common Genetic Variation in Relation to Brachial Vascular Dimensions and Flow-Mediated Vasodilation. CIRCULATION-GENOMIC AND PRECISION MEDICINE, 12(2). doi:10.1161/CIRCGEN.118.002409
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.
Morris, A. P., Le, T. H., Wu, H., Akbarov, A., van der Most, P. J., Hemani, G., . . . Franceschini, N. (2019). Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.. Nature communications, 10(1), 29. doi:10.1038/s41467-018-07867-7
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry
Pulit, S. L., Stoneman, C., Morris, A. P., Wood, A., Glastonbury, C. A., Tyrrell, J., . . . Lindgren, C. M. (2019). Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. HUMAN MOLECULAR GENETICS, 28(1), 166-174. doi:10.1093/hmg/ddy327
2018
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
Evangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsu, B., Pazoki, R., Gao, H., . . . Program, M. V. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50, 1412-1425. doi:10.1038/s41588-018-0205-x
Genome-Wide Association Studies of Estimated Fatty Acid Desaturase Activity in Serum and Adipose Tissue in Elderly Individuals: Associations with Insulin Sensitivity
Marklund, M., Morris, A. P., Mahajan, A., Ingelsson, E., Lindgren, C. M., Lind, L., & Riserus, U. (2018). Genome-Wide Association Studies of Estimated Fatty Acid Desaturase Activity in Serum and Adipose Tissue in Elderly Individuals: Associations with Insulin Sensitivity. NUTRIENTS, 10(11). doi:10.3390/nu10111791
Comparison of methods for transcriptome imputation through application to two common complex diseases
Fryett, J. J., Inshaw, J., Morris, A. P., & Cordell, H. J. (2018). Comparison of methods for transcriptome imputation through application to two common complex diseases. European Journal of Human Genetics, 26(11), 1658-1667. doi:10.1038/s41431-018-0176-5
Comparison of methods for transcriptome imputation through application to two common complex diseases
Fryett, J. J., Inshaw, J., Morris, A. P., & Cordell, H. J. (2018). Comparison of methods for transcriptome imputation through application to two common complex diseases. In EUROPEAN JOURNAL OF HUMAN GENETICS Vol. 26 (pp. 1658-1667). doi:10.1038/s41431-018-0176-5
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
Mahajan, A., Taliun, D., Thurner, M., Robertson, N. R., Torres, J. M., Rayner, N. W., . . . McCarthy, M. I. (2018). Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. NATURE GENETICS, 50(11), 1505-1513. doi:10.1038/s41588-018-0241-6
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders
Ligthart, S., Vaez, A., Vosa, U., Stathopoulou, M. G., de Vries, P. S., Prins, B. P., . . . Alizadeh, B. Z. (2018). Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. AMERICAN JOURNAL OF HUMAN GENETICS, 103(5), 691-706. doi:10.1016/j.ajhg.2018.09.009
Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition
Small, K. S., Todorcevic, M., Civelek, M., Moustafa, J. S. E. -S., Wang, X., Simon, M. M., . . . McCarthy, M. I. (2018). Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition. Nature Genetics, 50, 572-580. doi:10.1038/s41588-018-0088-x
Genetic inactivation of <i>ANGPTL4</i> improves glucose homeostasis and is associated with reduced risk of diabetes
Gusarova, V., O'Dushlaine, C., Teslovich, T. M., Benotti, P. N., Mirshahi, T., Gottesman, O., . . . Gromada, J. (2018). Genetic inactivation of <i>ANGPTL4</i> improves glucose homeostasis and is associated with reduced risk of diabetes. NATURE COMMUNICATIONS, 9. doi:10.1038/s41467-018-04611-z
Multi-ethnic genome-wide association study for atrial fibrillation
Roselli, C., Chaffin, M. D., Weng, L. -C., Aeschbacher, S., Ahlberg, G., Albert, C. M., . . . Ellinor, P. T. (2018). Multi-ethnic genome-wide association study for atrial fibrillation. Nature Genetics, 50, 1225-1233. doi:10.1038/s41588-018-0133-9
Progress in defining the genetic contribution to type 2 diabetes susceptibility.
Morris, A. P. (2018). Progress in defining the genetic contribution to type 2 diabetes susceptibility.. Current opinion in genetics & development, 50, 41-51. doi:10.1016/j.gde.2018.02.003
A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia
Chen, X., Gustafsson, S., Whitington, T., Borne, Y., Lorentzen, E., Sun, J., . . . Magnusson, P. K. E. (2018). A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia. HUMAN MOLECULAR GENETICS, 27(10), 1809-1818. doi:10.1093/hmg/ddy094
Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses
Painter, J. N., O'Mara, T. A., Morris, A. P., Cheng, T. H. T., Gorman, M., Martin, L., . . . Spurdle, A. B. (2018). Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses. CANCER MEDICINE, 7(5), 1978-1987. doi:10.1002/cam4.1445
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., . . . Grp, U. S. S. (2018). Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. NATURE GENETICS, 50, 26-41. doi:10.1038/s41588-017-0011-x
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
Mahajan, A., Wessel, J., Willems, S. M., Zhao, W., Robertson, N. R., Chu, A. Y., . . . Consortium, G. I. A. N. T. (2018). Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. NATURE GENETICS, 50(4), 559-571+. doi:10.1038/s41588-018-0084-1
A Meta-Analysis of Genome-Wide Association Studies of Growth Differentiation Factor-15 Concentration in Blood
Jiang, J., Thalamuthu, A., Ho, J. E., Mahajan, A., Ek, W. E., Brown, D. A., . . . Mather, K. A. (2018). A Meta-Analysis of Genome-Wide Association Studies of Growth Differentiation Factor-15 Concentration in Blood. FRONTIERS IN GENETICS, 9. doi:10.3389/fgene.2018.00097
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Malik, R., Chauhan, G., Traylor, M., Sargurupremraj, M., Okada, Y., Mishra, A., . . . Consortium, M. E. G. A. S. T. R. O. K. E. (2018). Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. NATURE GENETICS, 50(4), 524-537. doi:10.1038/s41588-018-0058-3
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
Sung, Y. J., Winkler, T. W., de las Fuentes, L., Bentley, A. R., Brown, M. R., Kraja, A. T., . . . Chasman, D. I. (2018). A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. AMERICAN JOURNAL OF HUMAN GENETICS, 102(3), 375-400. doi:10.1016/j.ajhg.2018.01.015
Progress in defining the genetic contribution to type 2 diabetes susceptibility
Morris, A. P. (2018). Progress in defining the genetic contribution to type 2 diabetes susceptibility. CURRENT OPINION IN GENETICS & DEVELOPMENT, 50, 41-51. doi:10.1016/j.gde.2018.02.003
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls (vol 4, 170179, 2017)
Flannick, J., Fuchsberger, C., Mahajan, A., Teslovich, T. M., Agarwala, V., Gaulton, K. J., . . . McCarthy, M. I. (2018). Sequence data and association statistics from 12,940 type 2 diabetes cases and controls (vol 4, 170179, 2017). SCIENTIFIC DATA, 5. doi:10.1038/sdata.2018.2
Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees
Jun, G., Manning, A., Almeida, M., Zawistowski, M., Wood, A. R., Teslovich, T. M., . . . Blangero, J. (2018). Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(2), 379-384. doi:10.1073/pnas.1705859115
Genome-Wide Association Study in 404,165 Individuals Identifies 139 Novel Signals of Association with Lung Function
Wain, L. V., Shrine, N., Guyatt, A. L., Jackson, V. E., Erzurumluoglu, A. M., Batini, C., . . . Tobin, M. D. (2018). Genome-Wide Association Study in 404,165 Individuals Identifies 139 Novel Signals of Association with Lung Function. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 197. Retrieved from https://www.webofscience.com/
Genome-wide association study in 404,165 individuals identifies 139 novel signals of association with lung function
Shrine, N., Guyatt, A. L., Jackson, V. E., Erzurumluoglu, A. M., Morris, A. P., Hall, I. P., . . . Wain, L. V. (2018). Genome-wide association study in 404,165 individuals identifies 139 novel signals of association with lung function. In GENETIC EPIDEMIOLOGY Vol. 42 (pp. 730-731). Retrieved from https://www.webofscience.com/
Large-scale trans-ethnic genome-wide association study reveals novel loci, causal molecular mechanisms and effector genes for kidney function
Franceschini, N., Le, T., Akbarov, A., Tomaszewski, M., & Morris, A. P. (2018). Large-scale trans-ethnic genome-wide association study reveals novel loci, causal molecular mechanisms and effector genes for kidney function. In GENETIC EPIDEMIOLOGY Vol. 42 (pp. 699). Retrieved from https://www.webofscience.com/
Meta-analysis of exome array data identifies six novel genetic loci for lung function
Jackson, V. E., Latourelle, J. C., Wain, L. V., Smith, A. V., Grove, M. L., Bartz, T. M., . . . London, S. J. (n.d.). Meta-analysis of exome array data identifies six novel genetic loci for lung function. Wellcome Open Research, 3, 4. doi:10.12688/wellcomeopenres.12583.1
Meta-analysis of exome array data identifies six novel genetic loci for lung function.
Jackson, V. E., Latourelle, J. C., Wain, L. V., Smith, A. V., Grove, M. L., Bartz, T. M., . . . London, S. J. (2018). Meta-analysis of exome array data identifies six novel genetic loci for lung function.. Wellcome open research, 3, 4. doi:10.12688/wellcomeopenres.12583.3
Population stratification in the Estonian biobank and its confounding with complex traits
Pervjakova, N., Lall, K., Mandul, M., Morris, A. P., Magi, R., & Fischer, K. (2018). Population stratification in the Estonian biobank and its confounding with complex traits. In GENETIC EPIDEMIOLOGY Vol. 42 (pp. 723). Retrieved from https://www.webofscience.com/
Prediction of CpG methylation status from SNP genotype data
Fryett, J. J., Morris, A. P., & Cordell, H. J. (2018). Prediction of CpG methylation status from SNP genotype data. In GENETIC EPIDEMIOLOGY Vol. 42 (pp. 699-700). Retrieved from https://www.webofscience.com/
Trans-ethnic meta-analysis of gestational diabetes reveals shared genetic background with type 2 diabetes
Pervjakova, N., Cook, J. P., Morris, A. P., Ferreira, T., & Magi, R. (2018). Trans-ethnic meta-analysis of gestational diabetes reveals shared genetic background with type 2 diabetes. In GENETIC EPIDEMIOLOGY Vol. 42 (pp. 693-694). Retrieved from https://www.webofscience.com/
2017
Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Flannick, J., Fuchsberger, C., Mahajan, A., Teslovich, T. M., Agarwala, V., Gaulton, K. J., . . . McCarthy, M. I. (2017). Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. SCIENTIFIC DATA, 4. doi:10.1038/sdata.2017.179
Exome-wide association study of plasma lipids in >300,000 individuals
Liu, D. J., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X., Mahajan, A., . . . Kathiresan, S. (2017). Exome-wide association study of plasma lipids in >300,000 individuals. NATURE GENETICS, 49(12), 1758-+. doi:10.1038/ng.3977
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass (vol 8, 80, 2017)
Zillikens, M. C., Demissie, S., Hsu, Y. -H., Yerges-Armstrong, L. M., Chou, W. -C., Stolk, L., . . . Kiel, D. P. (2017). Large meta-analysis of genome-wide association studies identifies five loci for lean body mass (vol 8, 80, 2017). NATURE COMMUNICATIONS, 8. doi:10.1038/s41467-017-01008-2
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.
Scott, R. A., Scott, L. J., Maegi, R., Marullo, L., Gaulton, K. J., Kaakinen, M., . . . Prokopenko, I. (2017). An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. DIABETES, 66(11), 2888-2902. doi:10.2337/db16-1253
Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation
Strawbridge, R. J., Silveira, A., den Hoed, M., Gustafsson, S., Luan, J., Rybin, D., . . . Hamsten, A. (2017). Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation. ATHEROSCLEROSIS, 266, 196-204. doi:10.1016/j.atherosclerosis.2017.09.031
Variability of genome-wide DNA methylation and mRNA expression profiles in reproductive and endocrine disease related tissues
Rahmioglu, N., Drong, A. W., Lockstone, H., Tapmeier, T., Hellner, K., Saare, M., . . . Zondervan, K. T. (2017). Variability of genome-wide DNA methylation and mRNA expression profiles in reproductive and endocrine disease related tissues. EPIGENETICS, 12(10), 897-908. doi:10.1080/15592294.2017.1367475
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals
Kraja, A. T., Cook, J. P., Warren, H. R., Surendran, P., Liu, C., Evangelou, E., . . . Howson, J. M. M. (2017). New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals. CIRCULATION-CARDIOVASCULAR GENETICS, 10(5). doi:10.1161/CIRCGENETICS.117.001778
Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution
Magi, R., Horikoshi, M., Sofer, T., Mahajan, A., Kitajima, H., Franceschini, N., . . . Morris, A. P. (2017). Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution. HUMAN MOLECULAR GENETICS, 26(18), 3639-3650. doi:10.1093/hmg/ddx280
Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry
Sapkota, Y., De Vivo, I., Steinthorsdottir, V., Fassbender, A., Bowdler, L., Buring, J. E., . . . Montgomery, G. W. (2017). Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry. SCIENTIFIC REPORTS, 7. doi:10.1038/s41598-017-10440-9
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis
Wheeler, E., Leong, A., Liu, C. -T., Hivert, M. -F., Strawbridge, R. J., Podmore, C., . . . Meigs, J. B. (2017). Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLOS MEDICINE, 14(9). doi:10.1371/journal.pmed.1002383
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney
Wain, L. V., Vaez, A., Jansen, R., Joehanes, R., van der Most, P. J., Erzurumluoglu, A. M., . . . Xiao, L. (2017). Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. HYPERTENSION, 70(3), E4-+. doi:10.1161/HYPERTENSIONAHA.117.09438
A rare-variant test for high-dimensional data.
Kaakinen, M., Magi, R., Fischer, K., Heikkinen, J., Jarvelin, M. -R., Morris, A. P., & Prokopenko, I. (2017). A rare-variant test for high-dimensional data. EUROPEAN JOURNAL OF HUMAN GENETICS, 25(8), 988-994. doi:10.1038/ejhg.2017.90
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Zillikens, M. C., Demissie, S., Hsu, Y. -H., Yerges-Armstrong, L. M., Chou, W. -C., Stolk, L., . . . Kiel, D. P. (2017). Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. NATURE COMMUNICATIONS, 8. doi:10.1038/s41467-017-00031-7
A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.
Manning, A., Highland, H. M., Gasser, J., Sim, X., Tukiainen, T., Fontanillas, P., . . . Lindgren, C. M. (2017). A Low-Frequency Inactivating <i>AKT2</i> Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. DIABETES, 66(7), 2019-2032. doi:10.2337/db16-1329
Genetic loci associated with heart rate variability and their effects on cardiac disease risk.
Nolte, I. M., Munoz, M. L., Tragante, V., Amare, A. T., Jansen, R., Vaez, A., . . . de Geus, E. J. C. (2017). Genetic loci associated with heart rate variability and their effects on cardiac disease risk. NATURE COMMUNICATIONS, 8. doi:10.1038/ncomms15805
Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel
Mitt, M., Kals, M., Parn, K., Gabriel, S. B., Lander, E. S., Palotie, A., . . . Palta, P. (2017). Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel. EUROPEAN JOURNAL OF HUMAN GENETICS, 25(7), 869-876. doi:10.1038/ejhg.2017.51
Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel.
Mitt, M., Kals, M., Parn, K., Gabriel, S. B., Lander, E. S., Palotie, A., . . . Palta, P. (2016). Improved Imputation Accuracy of Rare and Low-Frequency Genetic Variants Using Population-Specific High-Coverage Whole-Genome Sequencing Data Based Imputation Reference Panel. HUMAN HEREDITY, 81(4), 235. Retrieved from https://www.webofscience.com/
Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.
Tachmazidou, I., Suveges, D., Min, J. L., Ritchie, G. R. S., Steinberg, J., Walter, K., . . . Zeggini, E. (2017). Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits. AMERICAN JOURNAL OF HUMAN GENETICS, 100(6), 865-884. doi:10.1016/j.ajhg.2017.04.014
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.
Sapkota, Y., Steinthorsdottir, V., Morris, A. P., Fassbender, A., Rahmioglu, N., De Vivo, I., . . . Nyholt, D. R. (2017). Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism. NATURE COMMUNICATIONS, 8. doi:10.1038/ncomms15539
SurvivalGWAS_SV: software for the analysis of genome-wide association studies of imputed genotypes with "time-to-event" outcomes
Syed, H., Jorgensen, A. L., & Morris, A. P. (2017). SurvivalGWAS_SV: software for the analysis of genome-wide association studies of imputed genotypes with "time-to-event" outcomes. BMC bioinformatics, 18. doi:10.1186/s12859-017-1683-z
Copy number variations in "classical" obesity candidate genes are not frequently associated with severe early-onset obesity in children
Windholz, J., Kovacs, P., Schlicke, M., Franke, C., Mahajan, A., Morris, A. P., . . . Koerner, A. (2017). Copy number variations in "classical" obesity candidate genes are not frequently associated with severe early-onset obesity in children. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 30(5), 507-515. doi:10.1515/jpem-2016-0435
Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function
Wild, P. S., Felix, J. F., Schillert, A., Teumer, A., Chen, M. -H., Leening, M. J. G., . . . Doerr, M. (2017). Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function. JOURNAL OF CLINICAL INVESTIGATION, 127(5), 1798-1812. doi:10.1172/JCI84840
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
Justice, A. E., Winkler, T. W., Feitosa, M. F., Graff, M., Fisher, V. A., Young, K., . . . Cupples, L. A. (2017). Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. NATURE COMMUNICATIONS, 8. doi:10.1038/ncomms14977
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation
Christophersen, I. E., Rienstra, M., Roselli, C., Yin, X., Geelhoed, B., Barnard, J., . . . Ellinor, P. T. (2017). Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Nature Genetics, 49, 946-952. doi:10.1038/ng.3843
Genome-Wide Association Study of Nevirapine Hypersensitivity in a sub-Saharan African HIV-infected Population
Carr, D. F., Bourgeois, S., Chaponda, M., Takeshita, L., Morris, A., Cornejo Castro, E. M., . . . Pirmohamed, M. (2017). Genome-Wide Association Study of Nevirapine Hypersensitivity in a sub-Saharan African HIV-infected Population. Journal of Antimicrobial Chemotherapy, 72(4), 1152-1162. doi:10.1093/jac/dkw545
Genome-wide genetic analyses highlight mitogen-activated protein kinase (MAPK) signaling in the pathogenesis of endometriosis.
Uimari, O., Rahmioglu, N., Nyholt, D. R., Vincent, K., Missmer, S. A., Becker, C., . . . Zondervan, K. T. (2017). Genome-wide genetic analyses highlight mitogen-activated protein kinase (MAPK) signaling in the pathogenesis of endometriosis. HUMAN REPRODUCTION, 32(4), 780-793. doi:10.1093/humrep/dex024
Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease.
Folkersen, L., Fauman, E., Sabater-Lleal, M., Strawbridge, R. J., Franberg, M., Sennblad, B., . . . Malarstig, A. (2017). Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease. PLOS GENETICS, 13(4). doi:10.1371/journal.pgen.1006706
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
Wain, L. V., Shrine, N., Artigas, M. S., Erzurumluoglu, A. M., Noyvert, B., Bossini-Castillo, L., . . . Tobin, M. D. (2017). Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.. Nature Genetics, 49(3), 416-425. doi:10.1038/ng.3787
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Warren, H. R., Evangelou, E., Cabrera, C. P., Gao, H., Ren, M., Mifsud, B., . . . Grp, U. S. S. (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. NATURE GENETICS, 49(3), 403-415. doi:10.1038/ng.3768
MARV: a tool for genome-wide multi-phenotype analysis of rare variants
Kaakinen, M., Magi, R., Fischer, K., Heikkinen, J., Jarvelin, M. -R., Morris, A. P., & Prokopenko, I. (2017). MARV: a tool for genome-wide multi-phenotype analysis of rare variants. BMC BIOINFORMATICS, 18. doi:10.1186/s12859-017-1530-2
Rare and low-frequency coding variants alter human adult height
Marouli, E., Graff, M., Medina-Gomez, C., Lo, K. S., Wood, A. R., Kjaer, T. R., . . . Lettre, G. (2017). Rare and low-frequency coding variants alter human adult height. NATURE, 542(7640), 186-190. doi:10.1038/nature21039
A two-stage inter-rater approach for enrichment testing of variants associated with multiple traits
Asimit, J. L., Payne, F., Morris, A. P., Cordell, H. J., & Barroso, I. (2017). A two-stage inter-rater approach for enrichment testing of variants associated with multiple traits. EUROPEAN JOURNAL OF HUMAN GENETICS, 25(3), 341-349. doi:10.1038/ejhg.2016.171
Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal
Parra, E. J., Mazurek, A., Gignoux, C. R., Sockell, A., Agostino, M., Morris, A. P., . . . Cruz, M. (2017). Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the <i>BUD13</i>/<i>ZNF259</i>/<i>APOA5</i> region and fine mapping points to rs964184 as the main driver of the association signal. PLOS ONE, 12(2). doi:10.1371/journal.pone.0172880
Guidance for the utility of linear models in meta-analysis of genetic association studies of binary phenotypes
Cook, J. P., Mahajan, A., & Morris, A. P. (2017). Guidance for the utility of linear models in meta-analysis of genetic association studies of binary phenotypes. EUROPEAN JOURNAL OF HUMAN GENETICS, 25(2), 240-245. doi:10.1038/ejhg.2016.150
SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes
Magi, R., Suleimanov, Y. V., Clarke, G. M., Kaakinen, M., Fischer, K., Prokopenko, I., & Morris, A. P. (2017). SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes. BMC BIOINFORMATICS, 18. doi:10.1186/s12859-016-1437-3
Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for <i>RBPMS</i> in Erythropoiesis
van Rooij, F. J. A., Qayyum, R., Smith, A. V., Zhou, Y., Trompet, S., Tanaka, T., . . . Ganesh, S. K. (2017). Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for <i>RBPMS</i> in Erythropoiesis. AMERICAN JOURNAL OF HUMAN GENETICS, 100(1), 51-63. doi:10.1016/j.ajhg.2016.11.016
Development and Application of Methodology for the Analysis of Rare Genetic Variants with Time to Event Outcomes Using SurvivalGWAS_RV
Syed, H., Jorgensen, A. L., & Morris, A. P. (2017). Development and Application of Methodology for the Analysis of Rare Genetic Variants with Time to Event Outcomes Using SurvivalGWAS_RV. In GENETIC EPIDEMIOLOGY Vol. 41 (pp. 685-686). Retrieved from https://www.webofscience.com/
Discovery and Fine-Mapping of Type 2 Diabetes Susceptibility Loci Across Diverse Populations
Below, J. E., Kitajima, H., Mahajan, A., Sim, X., Ng, M., Zhang, W., . . . Morris, A. P. (2017). Discovery and Fine-Mapping of Type 2 Diabetes Susceptibility Loci Across Diverse Populations. In GENETIC EPIDEMIOLOGY Vol. 41 (pp. 650). Retrieved from https://www.webofscience.com/
Discovery and fine-mapping of type 2 diabetes susceptibility loci across diverse population
Kitajima, H., Mahajan, A., Sim, X., Ng, M. C., Zhang, W., Below, J. E., . . . Morris, A. P. (2017). Discovery and fine-mapping of type 2 diabetes susceptibility loci across diverse population. In DIABETOLOGIA Vol. 60 (pp. S8). Retrieved from https://www.webofscience.com/
Genetic and methylation variation in the CYP2B6 gene is related to circulating p,p '-dde levels in a population-based sample
Lind, L., Ng, E., Ingelsson, E., Lindgren, C., Salihovic, S., van Bavel, B., . . . Lind, P. M. (2017). Genetic and methylation variation in the CYP2B6 gene is related to circulating <i>p</i>,<i>p</i>′-dde levels in a population-based sample. ENVIRONMENT INTERNATIONAL, 98, 212-218. doi:10.1016/j.envint.2016.11.010
Genome-Wide Association Study Links Variants With Occurrence of Cardiovascular Events in People Taking the COX-2 Inhibitor Celecoxib: Identification of NCKX2 as a Novel Protective Pathway in Renal Vessels
Kirkby, N. S., Morris, A. P., Lytton, J., Seong, J. K., Bae, Y. S., Chu, J. H., . . . Mitchell, J. A. (2017). Genome-Wide Association Study Links Variants With Occurrence of Cardiovascular Events in People Taking the COX-2 Inhibitor Celecoxib: Identification of NCKX2 as a Novel Protective Pathway in Renal Vessels. In CIRCULATION Vol. 136. Retrieved from https://www.webofscience.com/
IDENTIFICATION OF GENETIC INTERACTIONS INVOLVED IN DYSLEXIA PATHOGENESIS
Karbalai, N., Czamara, D., Moll, K., Ramus, F., Malik, R., Scerri, T. S., . . . Muller-Myhsok, B. (2017). IDENTIFICATION OF GENETIC INTERACTIONS INVOLVED IN DYSLEXIA PATHOGENESIS. In EUROPEAN NEUROPSYCHOPHARMACOLOGY Vol. 27 (pp. S183-S184). Retrieved from https://www.webofscience.com/
Improving Gene Expression Prediction Accuracy in Transcriptome-Wide Association Studies
Fryett, J. J., Morris, A. P., & Cordell, H. J. (2017). Improving Gene Expression Prediction Accuracy in Transcriptome-Wide Association Studies. In HUMAN HEREDITY Vol. 83 (pp. 8). Retrieved from https://www.webofscience.com/
Investigating the prevalence, predictors, and prognosis of suboptimal statin use early after a non-ST elevation acute coronary syndrome
Turner, R. M., Yin, P., Hanson, A., FitzGerald, R., Morris, A. P., Stables, R. H., . . . Pirmohamed, M. (2017). Investigating the prevalence, predictors, and prognosis of suboptimal statin use early after a non-ST elevation acute coronary syndrome. Journal of Clinical Lipidology, 11(1), 204-214. doi:10.1016/j.jacl.2016.12.007
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation.
Chu, A. Y., Deng, X., Fisher, V. A., Drong, A., Zhang, Y., Feitosa, M. F., . . . Fox, C. S. (2017). Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation.. Nature Genetics, 49(1), 125-130. doi:10.1038/ng.3738
Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions.
Shungin, D., Deng, W. Q., Varga, T. V., Luan, J., Mihailov, E., Metspalu, A., . . . Franks, P. W. (2017). Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions. PLOS GENETICS, 13(6). doi:10.1371/journal.pgen.1006812
2016
SurvivalGWAS_Power: a user friendly tool for power calculations in pharmacogenetic studies with "time to event" outcomes
Syed, H., Jorgensen, A. L., & Morris, A. P. (2016). SurvivalGWAS_Power: a user friendly tool for power calculations in pharmacogenetic studies with "time to event" outcomes. BMC BIOINFORMATICS, 17. doi:10.1186/s12859-016-1407-9
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
Ried, J. S., Jeff, J. M., Chu, A. Y., Bragg-Gresham, J. L., van Dongen, J., Huffman, J. E., . . . Loos, R. J. F. (2016). A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. NATURE COMMUNICATIONS, 7. doi:10.1038/ncomms13357
SNP-Treatment Interactions of Cardiovascular Medications and Risk of Acute Coronary Syndrome Recurrence
Yin, P., Jorgensen, A., Morris, A., Turner, R., Fitzgerald, R., Stables, R., . . . Pirmohamed, M. (2016). SNP-Treatment Interactions of Cardiovascular Medications and Risk of Acute Coronary Syndrome Recurrence. In GENETIC EPIDEMIOLOGY Vol. 40 (pp. 672). Retrieved from https://www.webofscience.com/
Genome-wide associations for birth weight and correlations with adult disease
Horikoshi, M., Beaumont, R. N., Day, F. R., Warrington, N. M., Kooijman, M. N., Fernandez-Tajes, J., . . . Consortium, E. G. G. (2016). Genome-wide associations for birth weight and correlations with adult disease. NATURE, 538(7624), 248-252. doi:10.1038/nature19806
No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis
Loley, C., Alver, M., Assimes, T. L., Bjonnes, A., Goel, A., Gustafsson, S., . . . Koenig, I. R. (2016). No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis. SCIENTIFIC REPORTS, 6. doi:10.1038/srep35278
Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies <i>BCL2</i> and <i>FAM19A2</i> as Novel Insulin Sensitivity Loci
Walford, G. A., Gustafsson, S., Rybin, D., Stancakova, A., Chen, H., Liu, C. -T., . . . Florez, J. C. (2016). Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies <i>BCL2</i> and <i>FAM19A2</i> as Novel Insulin Sensitivity Loci. DIABETES, 65(10), 3200-3211. doi:10.2337/db16-0199
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
Ehret, G. B., Ferreira, T., Chasman, D. I., Jackson, A. U., Schmidt, E. M., Johnson, T., . . . Consor, W. T. C. C. (2016). The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. NATURE GENETICS, 48(10), 1171-1184. doi:10.1038/ng.3667
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
Surendran, P., Drenos, F., Young, R., Warren, H., Cook, J. P., Manning, A. K., . . . Munroe, P. B. (2016). Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. NATURE GENETICS, 48(10), 1151-1161. doi:10.1038/ng.3654
Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity
Mahajan, A., Rodan, A. R., Le, T. H., Gaulton, K. J., Haessler, J., Stilp, A. M., . . . Consortium, S. U. M. M. I. T. (2016). Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity. AMERICAN JOURNAL OF HUMAN GENETICS, 99(3), 636-646. doi:10.1016/j.ajhg.2016.07.012
Cystatin C and Cardiovascular Disease A Mendelian Randomization Study
van der Laan, S. W., Fall, T., Soumare, A., Teumer, A., Sedaghat, S., Baumert, J., . . . Asselbergs, F. W. (2016). Cystatin C and Cardiovascular Disease A Mendelian Randomization Study. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(9), 934-945. doi:10.1016/j.jacc.2016.05.092
The genetic architecture of type 2 diabetes
Fuchsberger, C., Flannick, J., Teslovich, T. M., Mahajan, A., Agarwala, V., Gaulton, K. J., . . . McCarthy, M. I. (2016). The genetic architecture of type 2 diabetes. NATURE, 536(7614), 41-+. doi:10.1038/nature18642
Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility
Cook, J. P., & Morris, A. P. (2016). Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility. EUROPEAN JOURNAL OF HUMAN GENETICS, 24(8), 1175-1180. doi:10.1038/ejhg.2016.17
Trans-ethnic study design approaches for fine-mapping
Asimit, J. L., Hatzikotoulas, K., McCarthy, M., Morris, A. P., & Zeggini, E. (2016). Trans-ethnic study design approaches for fine-mapping. EUROPEAN JOURNAL OF HUMAN GENETICS, 24(9), 1330-1336. doi:10.1038/ejhg.2016.1
Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin
Liu, C. -T., Raghavan, S., Maruthur, N., Kabagambe, E. K., Hong, J., Ng, M. C. Y., . . . Meigs, J. B. (2016). Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin. AMERICAN JOURNAL OF HUMAN GENETICS, 99(1), 56-75. doi:10.1016/j.ajhg.2016.05.006
Beyond Endometriosis Genome-Wide Association Study: From Genomics to Phenomics to the Patient
Zondervan, K. T., Rahmioglu, N., Morris, A. P., Nyholt, D. R., Montgomery, G. W., Becker, C. M., & Missmer, S. A. (2016). Beyond Endometriosis Genome-Wide Association Study: From Genomics to Phenomics to the Patient. SEMINARS IN REPRODUCTIVE MEDICINE, 34(4), 242-254. doi:10.1055/s-0036-1585408
A genomic approach to therapeutic target validation identifies a glucose-lowering <i>GLP1R</i> variant protective for coronary heart disease
Scott, R. A., Freitag, D. F., Li, L., Chu, A. Y., Surendran, P., Young, R., . . . Waterworth, D. M. (2016). A genomic approach to therapeutic target validation identifies a glucose-lowering <i>GLP1R</i> variant protective for coronary heart disease. SCIENCE TRANSLATIONAL MEDICINE, 8(341). doi:10.1126/scitranslmed.aad3744
Evaluation of methodology for the analysis of 'time-to-event' data in pharmacogenomic genome-wide association studies
Syed, H., Jorgensen, A. L., & Morris, A. P. (2016). Evaluation of methodology for the analysis of 'time-to-event' data in pharmacogenomic genome-wide association studies. PHARMACOGENOMICS, 17(8), 907-915. doi:10.2217/pgs.16.19
Imprinted genes and imprinting control regions show predominant intermediate methylation in adult somatic tissues
Pervjakova, N., Kasela, S., Morris, A. P., Kals, M., Metspalu, A., Lindgren, C. M., . . . Magi, R. (2016). Imprinted genes and imprinting control regions show predominant intermediate methylation in adult somatic tissues. EPIGENOMICS, 8(6), 789-799. doi:10.2217/epi.16.8
Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study
Prins, B. P., Abbasi, A., Wong, A., Vaez, A., Nolte, I., Franceschini, N., . . . Alizadeh, B. Z. (2016). Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. PLOS MEDICINE, 13(6). doi:10.1371/journal.pmed.1001976
Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms
Horikoshi, M., Pasquali, L., Wiltshire, S., Huyghe, J. R., Mahajan, A., Asimit, J. L., . . . Morris, A. P. (2016). Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. HUMAN MOLECULAR GENETICS, 25(10), 2070-2081. doi:10.1093/hmg/ddw048
Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight
Tyrrell, J., Richmond, R. C., Palmer, T. M., Feenstra, B., Rangarajan, J., Metrustry, S., . . . Freathy, R. M. (2016). Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 315(11), 1129-1140. doi:10.1001/jama.2016.1975
Genome-wide DNA methylation study identifies genes associated with the cardiovascular biomarker GDF-15
Ek, W. E., Hedman, A. K., Enroth, S., Morris, A. P., Lindgren, C. M., Mahajan, A., . . . Johansson, A. (2016). Genome-wide DNA methylation study identifies genes associated with the cardiovascular biomarker GDF-15. HUMAN MOLECULAR GENETICS, 25(4), 817-827. doi:10.1093/hmg/ddv511
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
Kilpelainen, T. O., Carli, J. F. M., Skowronski, A. A., Sun, Q., Kriebel, J., Feitosa, M. F., . . . Loos, R. J. F. (2016). Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. NATURE COMMUNICATIONS, 7. doi:10.1038/ncomms10494
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Lu, Y., Day, F. R., Gustafsson, S., Buchkovich, M. L., Na, J., Bataille, V., . . . Loos, R. J. F. (2016). New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. NATURE COMMUNICATIONS, 7. doi:10.1038/ncomms10495
Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs
Below, J. E., Parra, E. J., Gamazon, E. R., Torres, J., Krithika, S., Candille, S., . . . Valladares-Salgado, A. (2016). Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs. SCIENTIFIC REPORTS, 6. doi:10.1038/srep19429
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.
Knowles, J. W., Xie, W., Zhang, Z., Chennamsetty, I., Assimes, T. L., Paananen, J., . . . Quertermous, T. (2016). Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.. The Journal of clinical investigation, 126(1), 403. doi:10.1172/jci85921
A Genome-Wide Two-Component Mixture Model Expectation-Maximisation Algorithm for Time to Event Data
Francis, B., Yin, P., Cook, J. P., Jorgensen, A. L., Hutton, J., & Morris, A. P. (2016). A Genome-Wide Two-Component Mixture Model Expectation-Maximisation Algorithm for Time to Event Data. In HUMAN HEREDITY Vol. 81 (pp. 212-213). Retrieved from https://www.webofscience.com/
Investigating Fine-Scale Population Structure in UK BioBank
Cook, J. P., & Morris, A. P. (2016). Investigating Fine-Scale Population Structure in UK BioBank. In HUMAN HEREDITY Vol. 81 (pp. 225). Retrieved from https://www.webofscience.com/
Leveraging Population-Based Cohorts to Understand the Genetic Aetiology of Benign Gynaecological Disorders and Their Overlap: The UK Biobank.
Ferreira, T., Rahmioglu, N., Uimari, O., Becker, C. M., Morris, A. P., & Zondervan, K. T. (2016). Leveraging Population-Based Cohorts to Understand the Genetic Aetiology of Benign Gynaecological Disorders and Their Overlap: The UK Biobank.. In REPRODUCTIVE SCIENCES Vol. 23 (pp. 84A-85A). Retrieved from https://www.webofscience.com/
Multi-Phenotype Genome-Wide Meta-Analysis of Lipid Levels and BMI in 64,736 Europeans Suggests Shared Genetic Architecture
Kaakinen, M., Lagou, V., Magie, R., Fischer, K., Morris, A. P., & Prokopenko, I. (2016). Multi-Phenotype Genome-Wide Meta-Analysis of Lipid Levels and BMI in 64,736 Europeans Suggests Shared Genetic Architecture. In HUMAN HEREDITY Vol. 81 (pp. 213). Retrieved from https://www.webofscience.com/
SurvivalGWAS_RV: Software to Test Rare Variant Association with "Time-to-Event" Outcomes
Syed, H., Jorgensen, A. L., & Morris, A. P. (2016). SurvivalGWAS_RV: Software to Test Rare Variant Association with "Time-to-Event" Outcomes. In HUMAN HEREDITY Vol. 81 (pp. 230). Retrieved from https://www.webofscience.com/
2015
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
Artigas, M. S., Wain, L. V., Miller, S., Kheirallah, A. K., Huffman, J. E., Ntalla, I., . . . Zeggini, E. (2015). Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. NATURE COMMUNICATIONS, 6. doi:10.1038/ncomms9658
A Bayesian Approach to the Overlap Analysis of Epidemiologically Linked Traits
Asimit, J. L., Panoutsopoulou, K., Wheeler, E., Berndt, S. I., Cordell, H. J., Morris, A. P., . . . Barroso, I. (2015). A Bayesian Approach to the Overlap Analysis of Epidemiologically Linked Traits. GENETIC EPIDEMIOLOGY, 39(8), 624-634. doi:10.1002/gepi.21919
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Gaulton, K. J., Ferreira, T., Lee, Y., Raimondo, A., Mägi, R., Reschen, M. E., . . . Morris, A. (2015). Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nature Genetics, 47(12), 1415-1425. doi:10.1038/ng.3437
Shared genetics underlying epidemiological association between endometriosis and ovarian cancer
Lu, Y., Cuellar-Partida, G., Painter, J. N., Nyholt, D. R., Morris, A. P., Fasching, P. A., . . . MacGregor, S. (2015). Shared genetics underlying epidemiological association between endometriosis and ovarian cancer. HUMAN MOLECULAR GENETICS, 24(20), 5955-5964. doi:10.1093/hmg/ddv306
Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank
Wain, L. V., Shrine, N., Miller, S., Jackson, V. E., Ntalla, I., Artigas, M. S., . . . Hall, I. P. (2015). Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. LANCET RESPIRATORY MEDICINE, 3(10), 769-781. doi:10.1016/S2213-2600(15)00283-0
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
Nikpay, M., Goel, A., Won, H. -H., Hall, L. M., Willenborg, C., Kanoni, S., . . . Farrall, M. (2015). A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. NATURE GENETICS, 47(10), 1121-+. doi:10.1038/ng.3396
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
Liu, J. Z., van Sommeren, S., Huang, H., Ng, S. C., Alberts, R., Takahashi, A., . . . Weersma, R. K. (2015). Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. NATURE GENETICS, 47(9), 979-+. doi:10.1038/ng.3359
Directional dominance on stature and cognition in diverse human populations
Joshi, P. K., Esko, T., Mattsson, H., Eklund, N., Gandin, I., Nutile, T., . . . Wilson, J. F. (2015). Directional dominance on stature and cognition in diverse human populations. NATURE, 523(7561), 459-U176. doi:10.1038/nature14618
Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation
Horikoshi, M., Maegi, R., van de Bunt, M., Surakka, I., Sarin, A. -P., Mahajan, A., . . . Morris, A. P. (2015). Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation. PLOS GENETICS, 11(7). doi:10.1371/journal.pgen.1005230
Genetic burden associated with varying degrees of disease severity in endometriosis.
Sapkota, Y., Attia, J., Gordon, S. D., Henders, A. K., Holliday, E. G., Rahmioglu, N., . . . Nyholt, D. R. (2015). Genetic burden associated with varying degrees of disease severity in endometriosis.. Molecular human reproduction, 21(7), 594-602.
Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the <i>CYP2B6</i> gene in a population-based sample
Ng, E., Salihovic, S., Lind, P. M., Mahajan, A., Syvanen, A. -C., Axelsson, T., . . . Lind, L. (2015). Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the <i>CYP2B6</i> gene in a population-based sample. ENVIRONMENTAL RESEARCH, 140, 95-101. doi:10.1016/j.envres.2015.03.022
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
Coffee and Caffeine Genetics Consortium., Cornelis, M. C., Byrne, E. M., Esko, T., Nalls, M. A., Ganna, A., . . . Chasman, D. I. (2015). Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.. Molecular psychiatry, 20(5), 647-656. doi:10.1038/mp.2014.107
The impact of low-frequency and rare variants on lipid levels
Surakka, I., Horikoshi, M., Magi, R., Sarin, A. -P., Mahajan, A., Lagou, V., . . . Ripatti, S. (2015). The impact of low-frequency and rare variants on lipid levels. NATURE GENETICS, 47(6), 589-597. doi:10.1038/ng.3300
GWAS-identified loci for coronary heart disease are associated with intima-media thickness and plaque presence at the carotid artery bulb
den Hoed, M., Strawbridge, R. J., Almgren, P., Gustafsson, S., Axelsson, T., Engstrom, G., . . . Lind, L. (2015). GWAS-identified loci for coronary heart disease are associated with intima-media thickness and plaque presence at the carotid artery bulb. ATHEROSCLEROSIS, 239(2), 304-310. doi:10.1016/j.atherosclerosis.2015.01.032
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene
Knowles, J. W., Xie, W., Zhang, Z., Chennemsetty, I., Assimes, T. L., Paananen, J., . . . Quertermous, T. (2015). Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. JOURNAL OF CLINICAL INVESTIGATION, 125(4), 1739-1751. doi:10.1172/JCI74592
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene
Knowles, J. W., Xie, W., Zhang, Z., Chennemsetty, I., Assimes, T. L., Paananen, J., . . . Quertermous, T. (2015). Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. Journal of Clinical Investigation, 125(4), 1739-1751. doi:10.1172/jci74692
Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci
Rahmioglu, N., Macgregor, S., Drong, A. W., Hedman, A. K., Harris, H. R., Randall, J. C., . . . Zondervan, K. T. (2015). Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci. HUMAN MOLECULAR GENETICS, 24(4), 1185-1199. doi:10.1093/hmg/ddu516
Genetic studies of body mass index yield new insights for obesity biology
Locke, A. E., Kahali, B., Berndt, S. I., Justice, A. E., Pers, T. H., Day, F. R., . . . Speliotes, E. K. (2015). Genetic studies of body mass index yield new insights for obesity biology. NATURE, 518(7538), 197-U401. doi:10.1038/nature14177
New genetic loci link adipose and insulin biology to body fat distribution.
Shungin, D., Winkler, T. W., Croteau-Chonka, D. C., Ferreira, T., Locke, A. E., Mägi, R., . . . Mohlke, K. L. (2015). New genetic loci link adipose and insulin biology to body fat distribution.. Nature, 518(7538), 187-196. doi:10.1038/nature14132
Identification and Functional Characterization of <i>G6PC2</i> Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the <i>G6PC2</i>-<i>ABCB11</i> Locus
Mahajan, A., Sim, X., Ng, H. J., Manning, A., Rivas, M. A., Highland, H. M., . . . Gloyn, A. L. (2015). Identification and Functional Characterization of <i>G6PC2</i> Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the <i>G6PC2</i>-<i>ABCB11</i> Locus. PLOS GENETICS, 11(1). doi:10.1371/journal.pgen.1004876
Smoking is associated with mosaic loss of chromosome Y
Dumanski, J. P., Rasi, C., Lonn, M., Davies, H., Ingelsson, M., Giedraitis, V., . . . Forsberg, L. A. (2015). Smoking is associated with mosaic loss of chromosome Y. SCIENCE, 347(6217), 81-83. doi:10.1126/science.1262092
A Novel Method and Software Tool for Genome-Wide Multi-Phenotype Analysis of Rare Variants
Kaakinen, M., Maegi, R., Fischer, K., Jarvelin, M. -R., Morris, A. P., & Prokopenko, I. (2015). A Novel Method and Software Tool for Genome-Wide Multi-Phenotype Analysis of Rare Variants. In HUMAN HEREDITY Vol. 79 (pp. 39). Retrieved from https://www.webofscience.com/
Association between endometriosis and the interleukin 1A (IL1A) locus.
Sapkota, Y., Low, S. -K., Attia, J., Gordon, S. D., Henders, A. K., Holliday, E. G., . . . Nyholt, D. R. (2015). Association between endometriosis and the interleukin 1A (IL1A) locus.. Human reproduction (Oxford, England), 30(1), 239-248. doi:10.1093/humrep/deu267
Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci
van de Bunt, M., Cortes, A., Brown, M. A., Morris, A. P., & McCarthy, M. I. (2015). Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci. PLOS GENETICS, 11(9). doi:10.1371/journal.pgen.1005535
Evaluation of methodology for the analysis of "time-toevent" data in pharmacogenetic studies
Syed, H., Jorgensen, A., & Morris, A. P. (2015). Evaluation of methodology for the analysis of "time-toevent" data in pharmacogenetic studies. In GENETIC EPIDEMIOLOGY Vol. 39 (pp. 584). Retrieved from https://www.webofscience.com/
Fine Mapping of Type 2 Diabetes Susceptibility Loci (vol 14, 549, 2014)
Morris, A. P. (2015). Fine Mapping of Type 2 Diabetes Susceptibility Loci (vol 14, 549, 2014). CURRENT DIABETES REPORTS, 15(1). doi:10.1007/s11892-014-0575-0
Genome-wide association study imputed to 1000 Genomes Project reference panels reveals 17 novel associations with type 2 diabetes
Maegi, R., Scott, R. A., Morris, A. P., Marullo, L., Galton, K., Boehnke, M., . . . Prokopenko, I. (2015). Genome-wide association study imputed to 1000 Genomes Project reference panels reveals 17 novel associations with type 2 diabetes. In DIABETOLOGIA Vol. 58 (pp. S90). Retrieved from https://www.webofscience.com/
Genome-wide multi-phenotype rare variant association analysis detects effect of <i>ZNF259</i> on fasting insulin and triglyceride levels
Kaakinen, M., Maegi, R., Fischer, K., Jaervelin, M. -R., Morris, A. P., & Prokopenko, I. (2015). Genome-wide multi-phenotype rare variant association analysis detects effect of <i>ZNF259</i> on fasting insulin and triglyceride levels. In DIABETOLOGIA Vol. 58 (pp. S143). Retrieved from https://www.webofscience.com/
High-density imputation and trans-ethnic association analysis reveals a novel locus for type 2 diabetes susceptibility
Morris, A. P. (2015). High-density imputation and trans-ethnic association analysis reveals a novel locus for type 2 diabetes susceptibility. In DIABETOLOGIA Vol. 58 (pp. S89-S90). Retrieved from https://www.webofscience.com/
Large-scale exomechip association analysis identifies novel type 2 diabetes susceptibility loci and highlights candidate effector genes
Morris, A. P. (2015). Large-scale exomechip association analysis identifies novel type 2 diabetes susceptibility loci and highlights candidate effector genes. In GENETIC EPIDEMIOLOGY Vol. 39 (pp. 570). Retrieved from https://www.webofscience.com/
MARV: Anovel method and software tool for genome-wide multi-phenotype analysis of rare variants
Kaakinen, M., Magi, R., Fischer, K., Jarvelin, M. -R., Morris, A. P., & Prokopenko, I. (2015). MARV: Anovel method and software tool for genome-wide multi-phenotype analysis of rare variants. In GENETIC EPIDEMIOLOGY Vol. 39 (pp. 560). Retrieved from https://www.webofscience.com/
Methodology for the analysis of multi-ethnic genome-wide association studies
Cook, J. P., & Morris, A. P. (2015). Methodology for the analysis of multi-ethnic genome-wide association studies. In GENETIC EPIDEMIOLOGY Vol. 39 (pp. 540-541). Retrieved from https://www.webofscience.com/
Pharmacogenetics of Acute Coronary Syndrome
Yin, P., Jorgensen, A., Morris, A. P., Turner, R., Fitzgerald, R., Stables, R., . . . Pirmohamed, M. (2015). Pharmacogenetics of Acute Coronary Syndrome. In GENETIC EPIDEMIOLOGY Vol. 39 (pp. 596). Retrieved from https://www.webofscience.com/
Shared polygenic effects of FEV1 in the first genetic study in UK Biobank
Allen, R. J., Wain, L. V., Shrine, N., Miller, S., Jackson, V. E., Ntalla, I., . . . Tobin, M. D. (2015). Shared polygenic effects of FEV1 in the first genetic study in UK Biobank. In GENETIC EPIDEMIOLOGY Vol. 39 (pp. 529-530). Retrieved from https://www.webofscience.com/
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Winkler, T. W., Justice, A. E., Graff, M., Barata, L., Feitosa, M. F., Chu, S., . . . Loos, R. J. F. (2015). The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLOS GENETICS, 11(10). doi:10.1371/journal.pgen.1005378
Trans-ethnic meta-analysis reveals novel loci and effector genes for kidney function in diverse populations
Mahajan, A., Haessler, J., Okada, Y., Stilp, A., Whitfield, J., Laurie, C., . . . Morris, A. P. (2015). Trans-ethnic meta-analysis reveals novel loci and effector genes for kidney function in diverse populations. In GENETIC EPIDEMIOLOGY Vol. 39 (pp. 567). Retrieved from https://www.webofscience.com/
2014
Trans-ethnic meta-analysis of white blood cell phenotypes
Keller, M. F., Reiner, A. P., Okada, Y., van Rooij, F. J. A., Johnson, A. D., Chen, M. -H., . . . Nalls, M. A. (2014). Trans-ethnic meta-analysis of white blood cell phenotypes. HUMAN MOLECULAR GENETICS, 23(25), 6944-6960. doi:10.1093/hmg/ddu401
An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins
Yuan, W., Xia, Y., Bell, C. G., Yet, I., Ferreira, T., Ward, K. J., . . . Spector, T. D. (2014). An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins. NATURE COMMUNICATIONS, 5. doi:10.1038/ncomms6719
Defining the role of common variation in the genomic and biological architecture of adult human height
Wood, A. R., Esko, T., Yang, J., Vedantam, S., Pers, T. H., Gustafsson, S., . . . Frayling, T. M. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. NATURE GENETICS, 46(11), 1173-1186. doi:10.1038/ng.3097
Associations of genetic variants in/near body mass index- associated genes with type 2 diabetes: a systematic meta-analysis
Xi, B., Takeuchi, F., Meirhaeghe, A., Kato, N., Chambers, J. C., Morris, A., . . . Chandak, G. R. (2014). Associations of genetic variants in/near body mass index-associated genes with type 2 diabetes: a systematic meta-analysis. Clinical Endocrinology, 81(5), 702-710.
Fine Mapping of Type 2 Diabetes Susceptibility Loci
Morris, A. P. (2014). Fine Mapping of Type 2 Diabetes Susceptibility Loci. CURRENT DIABETES REPORTS, 14(11). doi:10.1007/s11892-014-0549-2
Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets
Rahmioglu, N., Nyholt, D. R., Morris, A. P., Missmer, S. A., Montgomery, G. W., & Zondervan, K. T. (2014). Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets. HUMAN REPRODUCTION UPDATE, 20(5), 702-716. doi:10.1093/humupd/dmu015
Methodology for the analysis of rare genetic variation in genome-wide association and re-sequencing studies of complex human traits
Moutsianas, L., & Morris, A. P. (2014). Methodology for the analysis of rare genetic variation in genome-wide association and re-sequencing studies of complex human traits. BRIEFINGS IN FUNCTIONAL GENOMICS, 13(5), 362-370. doi:10.1093/bfgp/elu012
Genetic variation in the CYP1A1 gene is related to circulating PCB118 levels in a population-based sample.
Lind, L., Penell, J., Syvänen, A. -C., Axelsson, T., Ingelsson, E., Morris, A. P., . . . Lind, P. M. (2014). Genetic variation in the CYP1A1 gene is related to circulating PCB118 levels in a population-based sample.. Environmental research, 133, 135-140. doi:10.1016/j.envres.2014.05.017
Pleiotropic genes for metabolic syndrome and inflammation.
Kraja, A. T., Chasman, D. I., North, K. E., Reiner, A. P., Yanek, L. R., Kilpeläinen, T. O., . . . Borecki, I. B. (2014). Pleiotropic genes for metabolic syndrome and inflammation.. Molecular Genetics and Metabolism, 112(4), 317-338.
Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin.
Bolton, J. L., Hayward, C., Direk, N., Lewis, J. G., Hammond, G. L., Hill, L. A., . . . Walker, B. R. (2014). Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin.. PLoS Genetics, 10(7), e1004474.
Genome-wide association analysis identifies six new loci associated with forced vital capacity.
Loth, D. W., Soler Artigas, M., Gharib, S. A., Wain, L. V., Franceschini, N., Koch, B., . . . London, S. J. (2014). Genome-wide association analysis identifies six new loci associated with forced vital capacity.. Nature genetics, 46(7), 669-677. doi:10.1038/ng.3011
Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function
Tang, W., Kowgier, M., Loth, D. W., Artigas, M. S., Joubert, B. R., Hodge, E., . . . Cassano, P. A. (2014). Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function. PLOS ONE, 9(7). doi:10.1371/journal.pone.0100776
Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer.
Forsberg, L. A., Rasi, C., Malmqvist, N., Davies, H., Pasupulati, S., Pakalapati, G., . . . Dumanski, J. P. (2014). Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer.. Nature Genetics, 46(6), 624-628.
Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study.
Langenberg, C., Sharp, S. J., Franks, P. W., Scott, R. A., Deloukas, P., Forouhi, N. G., . . . Wareham, N. J. (2014). Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study.. PLoS medicine, 11(5), e1001647.
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Mahajan, A., Go, M. J., Zhang, W., Below, J. E., Gaulton, K. J., Ferreira, T., . . . Morris, A. (2014). Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.. Nature Genetics, 46(3), 234-244. doi:10.1038/ng.2897
Dissecting the genetic architecture of loci with established effects on multiple cardiometabolic phenotypes and type 2 diabetes
Marullo, L., Kilpelainen, T. O., Cornes, B. K., Dupuis, J., Scapoli, C., Loos, R. J. F., . . . Prokopenko, I. (2014). Dissecting the genetic architecture of loci with established effects on multiple cardiometabolic phenotypes and type 2 diabetes. DIABETOLOGIA, 57, S149. Retrieved from https://www.webofscience.com/
FOXA2 bound sites are enriched for type 2 diabetes risk variants
Gaulton, K. J., Morris, A. P., & McCarthy, M. I. (2014). FOXA2 bound sites are enriched for type 2 diabetes risk variants. DIABETOLOGIA, 57, S66. Retrieved from https://www.webofscience.com/
Fine Mapping Type 2 Diabetes Susceptibility Loci
Morris, A. P. (2014). Fine Mapping Type 2 Diabetes Susceptibility Loci. GENETICS IN DIABETES: TYPE 2 DIABETES AND RELATED TRAITS, 23, 14-28. doi:10.1159/000362464
Fine-mapping type 2 diabetes susceptibility loci with high-density imputation
Morris, A. P., Teslovich, T. M., Ferreira, T., Mahajan, A., Lee, Y., Rayner, N. W., & Magi, R. (2014). Fine-mapping type 2 diabetes susceptibility loci with high-density imputation. DIABETOLOGIA, 57, S50-S51. Retrieved from https://www.webofscience.com/
Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
Becker, J., Czamara, D., Scerri, T. S., Ramus, F., Csepe, V., Talcott, J. B., . . . Schumacher, J. (2014). Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort. EUROPEAN JOURNAL OF HUMAN GENETICS, 22(5), 675-680. doi:10.1038/ejhg.2013.199
Genetic variation in the CYP2B6 gene is related to circulating 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) concentrations: an observational population-based study.
Penell, J., Lind, L., Fall, T., Syvänen, A. -C., Axelsson, T., Lundmark, P., . . . Lind, P. M. (2014). Genetic variation in the CYP2B6 gene is related to circulating 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) concentrations: an observational population-based study.. Environmental health : a global access science source, 13(1), 34.
Loss-of-function mutations in <i>SLC30A8</i> protect against type 2 diabetes
Flannick, J., Thorleifsson, G., Beer, N. L., Jacobs, S. B. R., Grarup, N., Burtt, N. P., . . . Altshuler, D. (2014). Loss-of-function mutations in <i>SLC30A8</i> protect against type 2 diabetes. NATURE GENETICS, 46(4), 357-+. doi:10.1038/ng.2915
Meta-analysis of birth weight genome-wide association studies identifies two novel loci extending links between early growth and adult metabolic diseases
Horikoshi, M., Kooijman, M. N., Bradield, J. P., Strachan, D., Tejedor, N. V., Kreiner-Moller, E., . . . Morris, A. P. (2014). Meta-analysis of birth weight genome-wide association studies identifies two novel loci extending links between early growth and adult metabolic diseases. DIABETOLOGIA, 57, S51. Retrieved from https://www.webofscience.com/