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Publications

Selected publications

  1. Defining the Surface Oxygen Threshold That Switches the Interaction Mode of Graphene Oxide with Bacteria (Journal article - 2023)
  2. The readability of parent information leaflets in paediatric studies (Journal article - 2023)
  3. Biotransformation modulates the penetration of metallic nanomaterials across an artificial blood-brain barrier model (Journal article - 2021)
  4. An Untargeted Thermogravimetric Analysis-Fourier Transform Infrared-Gas Chromatography-Mass Spectrometry Approach for Plastic Polymer Identification (Journal article - 2021)
  5. Environmental dimensions of the protein corona (Journal article - 2021)
  6. Capillary Electrophoresis-Mass Spectrometry at Trial by Metabo-Ring: Effective Electrophoretic Mobility for Reproducible and Robust Compound Annotation (Journal article - 2020)
  7. The Nanomaterial Metabolite Corona Determined Using a Quantitative Metabolomics Approach: A Pilot Study (Journal article - 2020)
  8. The potential of nanoflow liquid chromatography-nano electrospray ionisation-mass spectrometry for global profiling the faecal metabolome (Journal article - 2019)
  9. Quantitative Lipoprotein Subclass and Low Molecular Weight Metabolite Analysis in Human Serum and Plasma by <SUP>1</SUP>H NMR Spectroscopy in a Multilaboratory Trial (Journal article - 2018)
  10. A review of nanoscale LC-ESI for metabolomics and its potential to enhance the metabolome coverage (Journal article - 2018)
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2024

Analysis of nanomaterial biocoronas in biological and environmental surroundings.

Zhang, P., Cao, M., Chetwynd, A. J., Faserl, K., Abdolahpur Monikh, F., Zhang, W., . . . Lynch, I. (2024). Analysis of nanomaterial biocoronas in biological and environmental surroundings.. Nature protocols, 19(10), 3000-3047. doi:10.1038/s41596-024-01009-8

DOI
10.1038/s41596-024-01009-8
Journal article

Polar organic pollutants, micro-nano plastics and nanomaterials: Analytical techniques to reveal the still invisible human physico-chemical exposome

Chetwynd, A. J., Louyer, M. -V., Mercier, F., Bessonneau, V., & David, A. (2024). Polar organic pollutants, micro-nano plastics and nanomaterials: Analytical techniques to reveal the still invisible human physico-chemical exposome. TrAC Trends in Analytical Chemistry, 177, 117816. doi:10.1016/j.trac.2024.117816

DOI
10.1016/j.trac.2024.117816
Journal article

2023

2022

2021

Analytical Techniques for Material-limited Metabolomics: Recent Developments and Applications

Chetwynd, A. J., & Ramautar, R. (2021). Analytical Techniques for Material-limited Metabolomics: Recent Developments and Applications. In Advanced Mass Spectrometry-based Analytical Separation Techniques for Probing the Polar Metabolome (pp. 242-263). The Royal Society of Chemistry. doi:10.1039/9781839163524-00242

DOI
10.1039/9781839163524-00242
Chapter

Biotransformation modulates the penetration of metallic nanomaterials across an artificial blood-brain barrier model

Guo, Z., Zhang, P., Chakraborty, S., Chetwynd, A. J., Monikh, F. A., Stark, C., . . . Valsami-Jones, E. (2021). Biotransformation modulates the penetration of metallic nanomaterials across an artificial blood-brain barrier model. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(28). doi:10.1073/pnas.2105245118

DOI
10.1073/pnas.2105245118
Journal article

An Untargeted Thermogravimetric Analysis-Fourier Transform Infrared-Gas Chromatography-Mass Spectrometry Approach for Plastic Polymer Identification

Nel, H. A., Chetwynd, A. J., Kelly, C. A., Stark, C., Valsami-Jones, E., Krause, S., & Lynch, I. (2021). An Untargeted Thermogravimetric Analysis-Fourier Transform Infrared-Gas Chromatography-Mass Spectrometry Approach for Plastic Polymer Identification. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 55(13), 8721-8729. doi:10.1021/acs.est.1c01085

DOI
10.1021/acs.est.1c01085
Journal article

Environmental dimensions of the protein corona

Wheeler, K. E., Chetwynd, A. J., Fahy, K. M., Hong, B. S., Tochihuitl, J. A., Foster, L. A., & Lynch, I. (2021). Environmental dimensions of the protein corona. NATURE NANOTECHNOLOGY, 16(6), 617-629. doi:10.1038/s41565-021-00924-1

DOI
10.1038/s41565-021-00924-1
Journal article

Different physiological responses of C3 and C4 plants to nanomaterials

Bai, T., Zhang, P., Guo, Z., Chetwynd, A. J., Zhang, M., Adeel, M., . . . Rui, Y. (2021). Different physiological responses of C3 and C4 plants to nanomaterials. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 28(20), 25542-25551. doi:10.1007/s11356-021-12507-7

DOI
10.1007/s11356-021-12507-7
Journal article

Metabolic characterisation of disturbances in the <i>APOC3</i>/triglyceride-rich lipoprotein pathway through sample-based recall by genotype (vol 16, 69, 2020)

Corbin, L. J., Hughes, D. A., Chetwynd, A. J., Taylor, A. E., Southam, A. D., Jankevics, A., . . . Timpson, N. J. (2021). Metabolic characterisation of disturbances in the <i>APOC3</i>/triglyceride-rich lipoprotein pathway through sample-based recall by genotype (vol 16, 69, 2020). METABOLOMICS, 17(2). doi:10.1007/s11306-020-01765-0

DOI
10.1007/s11306-020-01765-0
Journal article

Physiological impacts of zero valent iron, Fe<sub>3</sub>O<sub>4</sub> and Fe<sub>2</sub>O<sub>3</sub> nanoparticles in rice plants and their potential as Fe fertilizers

Li, M., Zhang, P., Adeel, M., Guo, Z., Chetwynd, A. J., Ma, C., . . . Rui, Y. (2021). Physiological impacts of zero valent iron, Fe<sub>3</sub>O<sub>4</sub> and Fe<sub>2</sub>O<sub>3</sub> nanoparticles in rice plants and their potential as Fe fertilizers. ENVIRONMENTAL POLLUTION, 269. doi:10.1016/j.envpol.2020.116134

DOI
10.1016/j.envpol.2020.116134
Journal article

Analytical Techniques for Material-limited Metabolomics: Recent Developments and Applications

Chetwynd, A. J., & Ramautar, R. (2021). Analytical Techniques for Material-limited Metabolomics: Recent Developments and Applications. In ADVANCED MASS SPECTROMETRY-BASED ANALYTICAL SEPARATION TECHNIQUES FOR PROBING THE POLAR METABOLOME (Vol. 10, pp. 242-263). Retrieved from https://www.webofscience.com/

Chapter

Detection limits are central to improve reporting standards when using Nile red for microplastic quantification

Nel, H. A., Chetwynd, A. J., Kelleher, L., Lynch, I., Mansfield, I., Margenat, H., . . . Krause, S. (2021). Detection limits are central to improve reporting standards when using Nile red for microplastic quantification. CHEMOSPHERE, 263. doi:10.1016/j.chemosphere.2020.127953

DOI
10.1016/j.chemosphere.2020.127953
Journal article

2020

Capillary Electrophoresis Mass Spectrometry Approaches for Characterization of the Protein and Metabolite Corona Acquired by Nanomaterials

Chetwynd, A. J., Zhang, W., Faserl, K., Thorn, J. A., Lynch, I., Ramautar, R., & Lindner, H. H. (n.d.). Capillary Electrophoresis Mass Spectrometry Approaches for Characterization of the Protein and Metabolite Corona Acquired by Nanomaterials. Journal of Visualized Experiments, (164). doi:10.3791/61760-v

DOI
10.3791/61760-v
Journal article

Capillary Electrophoresis Mass Spectrometry Approaches for Characterization of the Protein and Metabolite Corona Acquired by Nanomaterials

Chetwynd, A. J., Zhang, W., Faserl, K., Thorn, J. A., Lynch, I., Ramautar, R., & Lindner, H. H. (2020). Capillary Electrophoresis Mass Spectrometry Approaches for Characterization of the Protein and Metabolite Corona Acquired by Nanomaterials. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (164). doi:10.3791/61760

DOI
10.3791/61760
Journal article

Capillary Electrophoresis-Mass Spectrometry at Trial by Metabo-Ring: Effective Electrophoretic Mobility for Reproducible and Robust Compound Annotation

Drouin, N., van Mever, M., Zhang, W., Tobolkina, E., Ferre, S., Servais, A. -C., . . . Ramautar, R. (2020). Capillary Electrophoresis-Mass Spectrometry at Trial by Metabo-Ring: Effective Electrophoretic Mobility for Reproducible and Robust Compound Annotation. ANALYTICAL CHEMISTRY, 92(20), 14103-14112. doi:10.1021/acs.analchem.0c03129

DOI
10.1021/acs.analchem.0c03129
Journal article

Elucidating the mechanism of the surface functionalization dependent neurotoxicity of graphene family nanomaterials

Guo, Z., Zhang, P., Chetwynd, A. J., Xie, H. Q., Valsami-Jones, E., Zhao, B., & Lynch, I. (2020). Elucidating the mechanism of the surface functionalization dependent neurotoxicity of graphene family nanomaterials. NANOSCALE, 12(36), 18600-18605. doi:10.1039/d0nr04179c

DOI
10.1039/d0nr04179c
Journal article

Metabolic characterisation of disturbances in the<i>APOC3</i>/triglyceride-rich lipoprotein pathway through sample-based recall by genotype

Corbin, L. J., Hughes, D. A., Chetwynd, A. J., Taylor, A. E., Southam, A. D., Jankevics, A., . . . Timpson, N. J. (2020). Metabolic characterisation of disturbances in the<i>APOC3</i>/triglyceride-rich lipoprotein pathway through sample-based recall by genotype. METABOLOMICS, 16(6). doi:10.1007/s11306-020-01689-9

DOI
10.1007/s11306-020-01689-9
Journal article

The Nanomaterial Metabolite Corona Determined Using a Quantitative Metabolomics Approach: A Pilot Study

Chetwynd, A. J., Zhang, W., Thorn, J. A., Lynch, I., & Ramautar, R. (2020). The Nanomaterial Metabolite Corona Determined Using a Quantitative Metabolomics Approach: A Pilot Study. SMALL, 16(21). doi:10.1002/smll.202000295

DOI
10.1002/smll.202000295
Journal article

Fast and Robust Proteome Screening Platform Identifies Neutrophil Extracellular Trap Formation in the Lung in Response to Cobalt Ferrite Nanoparticles

Billing, A. M., Knudsen, K. B., Chetwynd, A. J., Ellis, L. -J. A., Tang, S. V. Y., Berthing, T., . . . Kjeldsen, F. (2020). Fast and Robust Proteome Screening Platform Identifies Neutrophil Extracellular Trap Formation in the Lung in Response to Cobalt Ferrite Nanoparticles. ACS NANO, 14(4), 4096-4110. doi:10.1021/acsnano.9b08818

DOI
10.1021/acsnano.9b08818
Journal article

The rise of the nanomaterial metabolite corona, and emergence of the complete corona

Chetwynd, A. J., & Lynch, I. (2020). The rise of the nanomaterial metabolite corona, and emergence of the complete corona. ENVIRONMENTAL SCIENCE-NANO, 7(4), 1041-1060. doi:10.1039/c9en00938h

DOI
10.1039/c9en00938h
Journal article

Deciphering the particle specific effects on metabolism in rat liver and plasma from ZnO nanoparticles versus ionic Zn exposure

Guo, Z., Luo, Y., Zhang, P., Chetwynd, A. J., Xie, H. Q., Monikh, F. A., . . . Zhao, B. (2020). Deciphering the particle specific effects on metabolism in rat liver and plasma from ZnO nanoparticles versus ionic Zn exposure. ENVIRONMENT INTERNATIONAL, 136. doi:10.1016/j.envint.2019.105437

DOI
10.1016/j.envint.2019.105437
Journal article

Surface Chemistry-Dependent Evolution of the Nanomaterial Corona on TiO<sub>2</sub> Nanomaterials Following Uptake and Sub-Cellular Localization

Khan, A. O., Di Maio, A., Guggenheim, E. J., Chetwynd, A. J., Pencross, D., Tang, S., . . . Lynch, I. (2020). Surface Chemistry-Dependent Evolution of the Nanomaterial Corona on TiO<sub>2</sub> Nanomaterials Following Uptake and Sub-Cellular Localization. NANOMATERIALS, 10(3). doi:10.3390/nano10030401

DOI
10.3390/nano10030401
Journal article

2019

Best practice in reporting corona studies: Minimum information about Nanomaterial Biocorona Experiments (MINBE)

Chetwynd, A. J., Wheeler, K. E., & Lynch, I. (2019). Best practice in reporting corona studies: Minimum information about Nanomaterial Biocorona Experiments (MINBE). NANO TODAY, 28. doi:10.1016/j.nantod.2019.06.004

DOI
10.1016/j.nantod.2019.06.004
Journal article

On the issue of transparency and reproducibility in nanomedicine (vol 14, pg 629, 2019)

Leong, H. S., Butler, K. S., Brinker, C. J., Azzawi, M., Conlan, S., Dufes, C., . . . Pastore, C. (2019). On the issue of transparency and reproducibility in nanomedicine (vol 14, pg 629, 2019). NATURE NANOTECHNOLOGY, 14(9), 902. doi:10.1038/s41565-019-0538-3

DOI
10.1038/s41565-019-0538-3
Journal article

The potential of nanoflow liquid chromatography-nano electrospray ionisation-mass spectrometry for global profiling the faecal metabolome

Chetwynd, A. J., Ogilvie, L. A., Nzakizwanayo, J., Pazdirek, F., Hoch, J., Dedi, C., . . . Hill, E. M. (2019). The potential of nanoflow liquid chromatography-nano electrospray ionisation-mass spectrometry for global profiling the faecal metabolome. JOURNAL OF CHROMATOGRAPHY A, 1600, 127-136. doi:10.1016/j.chroma.2019.04.028

DOI
10.1016/j.chroma.2019.04.028
Journal article

On the issue of transparency and reproducibility in nanomedicine (vol 14, pg 629, 2019)

Leong, H. S., Butler, K. S., Brinker, C. J., Azzawi, M., Conlan, S., Dufes, C., . . . Pastore, C. (2019). On the issue of transparency and reproducibility in nanomedicine (vol 14, pg 629, 2019). NATURE NANOTECHNOLOGY, 14(8), 811. doi:10.1038/s41565-019-0523-x

DOI
10.1038/s41565-019-0523-x
Journal article

On the issue of transparency and reproducibility in nanomedicine

Leong, H. S., Butler, K. S., Brinker, C. J., Azzawi, M., Conlan, S., Dufes, C., . . . Pastore, C. (2019). On the issue of transparency and reproducibility in nanomedicine. NATURE NANOTECHNOLOGY, 14(7), 629-635. doi:10.1038/s41565-019-0496-9

DOI
10.1038/s41565-019-0496-9
Journal article

Corona Isolation Method Matters: Capillary Electrophoresis Mass Spectrometry Based Comparison of Protein Corona Compositions Following On-Particle versus In-Solution or In-Gel Digestion

Faserl, K., Chetwynd, A. J., Lynch, I., Thorn, J. A., & Lindner, H. H. (2019). Corona Isolation Method Matters: Capillary Electrophoresis Mass Spectrometry Based Comparison of Protein Corona Compositions Following On-Particle versus In-Solution or In-Gel Digestion. NANOMATERIALS, 9(6). doi:10.3390/nano9060898

DOI
10.3390/nano9060898
Journal article

2018

Quantitative Lipoprotein Subclass and Low Molecular Weight Metabolite Analysis in Human Serum and Plasma by <SUP>1</SUP>H NMR Spectroscopy in a Multilaboratory Trial

Jimenez, B., Holmes, E., Heude, C., Tolson, R. F., Harvey, N., Lodge, S. L., . . . Nicholson, J. K. (2018). Quantitative Lipoprotein Subclass and Low Molecular Weight Metabolite Analysis in Human Serum and Plasma by <SUP>1</SUP>H NMR Spectroscopy in a Multilaboratory Trial. ANALYTICAL CHEMISTRY, 90(20), 11962-11971. doi:10.1021/acs.analchem.8b02412

DOI
10.1021/acs.analchem.8b02412
Journal article

A review of nanoscale LC-ESI for metabolomics and its potential to enhance the metabolome coverage

Chetwynd, A. J., & David, A. (2018). A review of nanoscale LC-ESI for metabolomics and its potential to enhance the metabolome coverage. TALANTA, 182, 380-390. doi:10.1016/j.talanta.2018.01.084

DOI
10.1016/j.talanta.2018.01.084
Journal article

Current Application of Capillary Electrophoresis in Nanomaterial Characterisation and Its Potential to Characterise the Protein and Small Molecule Corona

Chetwynd, A. J., Guggenheim, E. J., Briffa, S. M., Thorn, J. A., Lynch, I., & Valsami-Jones, E. (2018). Current Application of Capillary Electrophoresis in Nanomaterial Characterisation and Its Potential to Characterise the Protein and Small Molecule Corona. NANOMATERIALS, 8(2). doi:10.3390/nano8020099

DOI
10.3390/nano8020099
Journal article

2017

msPurity: Automated Evaluation of Precursor Ion Purity for Mass Spectrometry-Based Fragmentation in Metabolomics

Lawson, T. N., Weber, R. J. M., Jones, M. R., Chetwynd, A. J., Rodriguez-Blanco, G., Di Guida, R., . . . Dunn, W. B. (2017). msPurity: Automated Evaluation of Precursor Ion Purity for Mass Spectrometry-Based Fragmentation in Metabolomics. ANALYTICAL CHEMISTRY, 89(4), 2432-2439. doi:10.1021/acs.analchem.6b04358

DOI
10.1021/acs.analchem.6b04358
Journal article

Nanoflow-Nanospray Mass Spectrometry Metabolomics Reveals Disruption of the Urinary Metabolite Profiles of HIV-Positive Patients on Combination Antiretroviral Therapy

Chetwynd, A. J., Samarawickrama, A., Vera, J. H., Bremner, S. A., Abdul-Sada, A., Gilleece, Y., . . . Hill, E. M. (2017). Nanoflow-Nanospray Mass Spectrometry Metabolomics Reveals Disruption of the Urinary Metabolite Profiles of HIV-Positive Patients on Combination Antiretroviral Therapy. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 74(2), E45-E53. doi:10.1097/QAI.0000000000001159

DOI
10.1097/QAI.0000000000001159
Journal article

Collection and Preparation of Clinical Samples for Metabolomics.

Chetwynd, A. J., Dunn, W. B., & Rodriguez-Blanco, G. (2017). Collection and Preparation of Clinical Samples for Metabolomics.. In Unknown Book (Vol. 965, pp. 19-44). doi:10.1007/978-3-319-47656-8_2

DOI
10.1007/978-3-319-47656-8_2
Chapter

2016

Use of a pre-analysis osmolality normalisation method to correct for variable. urine concentrations and for improved metabolomic analyses

Chetwynd, A. J., Abdul-Sada, A., Holt, S. G., & Hill, E. M. (2016). Use of a pre-analysis osmolality normalisation method to correct for variable. urine concentrations and for improved metabolomic analyses. JOURNAL OF CHROMATOGRAPHY A, 1431, 103-110. doi:10.1016/j.chroma.2015.12.056

DOI
10.1016/j.chroma.2015.12.056
Journal article

Differences in urine metabolomes with HIV infection and antiretroviral drug exposure

Chetwynd, A., Abdul-Sada, A., Hill, E., Vera, J., Fisher, M., Samarawickrama, A., . . . Gilleece, Y. (2016). Differences in urine metabolomes with HIV infection and antiretroviral drug exposure. In HIV MEDICINE Vol. 17 (pp. 37). Retrieved from https://www.webofscience.com/

Conference Paper

2015

Solid-Phase Extraction and Nanoflow Liquid Chromatography-Nanoelectrospray Ionization Mass Spectrometry for Improved Global Urine Metabolomics

Chetwynd, A. J., Abdul-Sada, A., & Hill, E. M. (2015). Solid-Phase Extraction and Nanoflow Liquid Chromatography-Nanoelectrospray Ionization Mass Spectrometry for Improved Global Urine Metabolomics. ANALYTICAL CHEMISTRY, 87(2), 1158-1165. doi:10.1021/ac503769q

DOI
10.1021/ac503769q
Journal article

2014

Evaluation of analytical performance and reliability of direct nanoLC-nanoESI-high resolution mass spectrometry for profiling the (xeno)metabolome

Chetwynd, A. J., David, A., Hill, E. M., & Abdul-Sada, A. (2014). Evaluation of analytical performance and reliability of direct nanoLC-nanoESI-high resolution mass spectrometry for profiling the (xeno)metabolome. JOURNAL OF MASS SPECTROMETRY, 49(10), 1063-1069. doi:10.1002/jms.3426

DOI
10.1002/jms.3426
Journal article