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Andrew Carnell

Professor Andrew Carnell
BSc PhD FHEA

Contact

A.J.Carnell@liverpool.ac.uk

Carnell Group website

+44 (0)151 794 1304

+44 (0)151 794 3531

Publications

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2023

2022

Carboxyl Methyltransferase Catalysed Formation of Mono- and Dimethyl Esters under Aqueous Conditions: Application in Cascade Biocatalysis

Ward, L. C., McCue, H. V., Rigden, D. J., Kershaw, N. M., Ashbrook, C., Hatton, H., . . . Carnell, A. J. (2022). Carboxyl Methyltransferase Catalysed Formation of Mono- and Dimethyl Esters under Aqueous Conditions: Application in Cascade Biocatalysis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 61(14). doi:10.1002/anie.202117324

DOI
10.1002/anie.202117324
Journal article

2021

2019

2017

2016

Label-Free Surface Enhanced Raman Scattering Approach for High-Throughput Screening of Biocatalysts

Westley, C., Xu, Y., Carnell, A. J., Turner, N. J., & Goodacre, R. (2016). Label-Free Surface Enhanced Raman Scattering Approach for High-Throughput Screening of Biocatalysts. Analytical Chemistry, 88(11), 5898-5903. doi:10.1021/acs.analchem.6b00813

DOI
10.1021/acs.analchem.6b00813
Journal article

2015

Galactose Oxidase Variants for the Oxidation of Amino Alcohols in Enzyme Cascade Synthesis

Herter, S., McKenna, S., Frazer, A. R., Leimkühler, S., Carnell, A., & Turner, N. J. (2015). Galactose Oxidase Variants for the Oxidation of Amino Alcohols in Enzyme Cascade Synthesis. ChemCatChem, 7(15), 2313-2317. doi:10.1002/cctc.201500218

DOI
10.1002/cctc.201500218
Journal article

Enzyme cascade reactions: synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem

McKenna, S., Leimkühler, S., Herter, S., Turner, N. J., & Carnell, A. (2015). Enzyme cascade reactions: synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem. Green Chemistry, 17(6), 3271-3275. doi:10.1039/c5gc00707k

DOI
10.1039/c5gc00707k
Journal article

2014

Catalytic bio–chemo and bio–bio tandem oxidation reactions for amide and carboxylic acid synthesis

Herter, S., Bechi, B., McKenna, S., Riley, C., Leimkühler, S., Turner, N. J., & Carnell, A. (2014). Catalytic bio–chemo and bio–bio tandem oxidation reactions for amide and carboxylic acid synthesis. Green Chemistry, 16(10), 4524-4529. doi:10.1039/C4GC01321B

DOI
10.1039/C4GC01321B
Journal article

Glycosylated yellow laccases of the basidiomycete Stropharia aeruginosa

Daroch, M., Houghton, C. A., Moore, J. K., Wilkinson, M. C., Carnell, A. J., Bates, A. D., & Iwanejko, L. A. (2014). Glycosylated yellow laccases of the basidiomycete Stropharia aeruginosa. Enzyme and Microbial Techenology, 58-59, 1-7. doi:10.1016/j.enzmictec.2014.02.003

DOI
10.1016/j.enzmictec.2014.02.003
Journal article

Trifluoroibuprofen Inhibits α-Methylacyl Coenzyme A Racemase (AMACR/P504S), Reduces Cancer Cell Proliferation and Inhibits <i>in vivo</i> Tumor Growth in Aggressive Prostate Cancer Models

Festuccia, C., Gravina, G. L., Mancini, A., Muzi, P., Di Cesare, E., Kirk, R., . . . Carnell, A. J. (2014). Trifluoroibuprofen Inhibits α-Methylacyl Coenzyme A Racemase (AMACR/P504S), Reduces Cancer Cell Proliferation and Inhibits <i>in vivo</i> Tumor Growth in Aggressive Prostate Cancer Models. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 14(7), 1031-1041. doi:10.2174/1871520614666140327152607

DOI
10.2174/1871520614666140327152607
Journal article

LIPID METHABOLISM AS THERAPEUTIC TARGET FOR PROSTATE CANCER

Festuccia, C., Mancini, A., Marampon, F., Scarsella, L., Jitariuc, A., Colapietro, A., . . . Gravina, G. L. (2014). LIPID METHABOLISM AS THERAPEUTIC TARGET FOR PROSTATE CANCER. ANTICANCER RESEARCH, 34(5), 2656-2657. Retrieved from https://www.webofscience.com/

Journal article

Synthetic Cascades by Combining Evolved Biocatalysts and Artificial Enzymes

Carnell, A. J. (2014). Synthetic Cascades by Combining Evolved Biocatalysts and Artificial Enzymes. CHEMCATCHEM, 6(4), 958-960. doi:10.1002/cctc.201402143

DOI
10.1002/cctc.201402143
Journal article

2013

Inhibition of Human α-Methylacyl CoA Racemase (AMACR): a Target for Prostate Cancer

Carnell, A. J., Kirk, R., Smith, M., McKenna, S., Lian, L. -Y., & Gibson, R. (2013). Inhibition of Human α-Methylacyl CoA Racemase (AMACR): a Target for Prostate Cancer. CHEMMEDCHEM, 8(10), 1643-1647. doi:10.1002/cmdc.201300179

DOI
10.1002/cmdc.201300179
Journal article

2012

Enantioselective Rhodium-Catalyzed Addition of Potassium Alkenyltrifluoroborates to Cyclic Imines

Luo, Y., Carnell, A. J., & Lam, H. W. (2012). Enantioselective Rhodium-Catalyzed Addition of Potassium Alkenyltrifluoroborates to Cyclic Imines. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(27), 6762-6766. doi:10.1002/anie.201202136

DOI
10.1002/anie.201202136
Journal article

Chiral bicyclic [2.2.2] octadiene ligands for Rh-catalysed catalytic asymmetric conjugate additions to acyclic enones: a quantitative structure-property relationship

Luo, Y., Berry, N. G., & Carnell, A. J. (2012). Chiral bicyclic [2.2.2] octadiene ligands for Rh-catalysed catalytic asymmetric conjugate additions to acyclic enones: a quantitative structure-property relationship. CHEMICAL COMMUNICATIONS, 48(27), 3279-3281. doi:10.1039/c2cc17120a

DOI
10.1039/c2cc17120a
Journal article

2010

Chemoenzymatic Synthesis and Application of Bicyclo[2.2.2]octadiene Ligands: Increased Efficiency in Rhodium-Catalyzed Asymmetric Conjugate Additions by Electronic Tuning

Luo, Y., & Carnell, A. J. (2010). Chemoenzymatic Synthesis and Application of Bicyclo[2.2.2]octadiene Ligands: Increased Efficiency in Rhodium-Catalyzed Asymmetric Conjugate Additions by Electronic Tuning. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 49(15), 2750-2754. doi:10.1002/anie.200907033

DOI
10.1002/anie.200907033
Journal article

A Practical Chemo-enzymatic Synthesis of Homochiral Bicyclo[2.2.2]octane-2,5-dione

Luo, Y., & Carnell, A. J. (2010). A Practical Chemo-enzymatic Synthesis of Homochiral Bicyclo[2.2.2]octane-2,5-dione. JOURNAL OF ORGANIC CHEMISTRY, 75(6), 2057-2060. doi:10.1021/jo9023705

DOI
10.1021/jo9023705
Journal article

A new chemoenzymatic approach to chiral bicyclic [2.2.2]octan-2,5-diones and diene ligands

Carnell, A. J. (2010). A new chemoenzymatic approach to chiral bicyclic [2.2.2]octan-2,5-diones and diene ligands. In Biocatalysis: Challenges for Pharmaceuticals & Fine Chemicals (pp. 000). London: SCI.

Conference Paper

Characterisation and inhibition of alpha-methylacylCoA racemase (AMACR1A): a potential therapeutic target for prostate cancer

Carnell, A. J. (2010). Characterisation and inhibition of alpha-methylacylCoA racemase (AMACR1A): a potential therapeutic target for prostate cancer. In Cancer Research Scientific Symposium 2010 (pp. na). Liverpool: na.

Conference Paper

2009

Kinetic Resolutions Using Biotransformations

Gadler, P., Faber, K., Savile, C. K., Kazlauskas, R. J., Carnell, A. J., & Breen, G. (2009). Kinetic Resolutions Using Biotransformations. In Unknown Book (pp. 117-131). Wiley. doi:10.1002/9780470748589.ch3

DOI
10.1002/9780470748589.ch3
Chapter

Increasing efficiency in the synthesis of pharmaceuticals and chiral ligands using enzymes

Carnell, A. J. (2009). Increasing efficiency in the synthesis of pharmaceuticals and chiral ligands using enzymes. In RSC Advancing the Chemical Sciences (pp. 01). London: RSC.

Conference Paper

Microbial transformation of hydroxy metabolites of 1-oxohexyl derivatives of theobromine by <i>Cunninghamella echinulata</i> NRRL 1384

Pekala, E., Kochan, M., & Carnell, A. J. (2009). Microbial transformation of hydroxy metabolites of 1-oxohexyl derivatives of theobromine by <i>Cunninghamella echinulata</i> NRRL 1384. LETTERS IN APPLIED MICROBIOLOGY, 48(1), 19-24. doi:10.1111/j.1472-765X.2008.02478.x

DOI
10.1111/j.1472-765X.2008.02478.x
Journal article

2008

Designing inhibitors for alpha-methylacayl CoA racemase (AMACR), a biomarker and novel therapeutic target for prostate cancer

Carnell, A. J. (2008). Designing inhibitors for alpha-methylacayl CoA racemase (AMACR), a biomarker and novel therapeutic target for prostate cancer. In RSC Bio-Organic Group Forum (pp. 01). Leicester: RSC.

Conference Paper

2007

Design, synthesis, and in vitro testing of α-methylacyl-CoA racemase inhibitors

Carnell, A. J., Hale, I., Denis, S., Wanders, R. J. A., Isaacs, W. B., Wilson, B. A., & Ferdinandusse, S. (2007). Design, synthesis, and in vitro testing of α-methylacyl-CoA racemase inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, 50(11), 2700-2707. doi:10.1021/jm0702377

DOI
10.1021/jm0702377
Journal article

2004

Efficient large scale stereoinversion of (<i>R</i>)-ethyl 3-hydroxybutyrate

Carnell, A. J., Head, R., Bassett, D., & Schneider, M. (2004). Efficient large scale stereoinversion of (<i>R</i>)-ethyl 3-hydroxybutyrate. TETRAHEDRON-ASYMMETRY, 15(5), 821-825. doi:10.1016/j.tetasy.2003.12.005

DOI
10.1016/j.tetasy.2003.12.005
Journal article

Microbial deracemisation of <i>N</i>-(1-hydroxy-1-phenylethyl)benzamide

Cardus, G. J., Carnell, A. J., Trauthwein, H., & Riermeir, T. (2004). Microbial deracemisation of <i>N</i>-(1-hydroxy-1-phenylethyl)benzamide. TETRAHEDRON-ASYMMETRY, 15(2), 239-243. doi:10.1016/j.tetasy.2003.11.010

DOI
10.1016/j.tetasy.2003.11.010
Journal article

2003

The synthesis of buprenorphine intermediates by regioselective microbial <i>N</i>- and <i>O</i>-demethylation reactions using <i>Cunninghamella echinulata</i> NRRL 1384

Abel, A. M., Carnell, A. J., Davis, J. A., & Paylor, M. (2003). The synthesis of buprenorphine intermediates by regioselective microbial <i>N</i>- and <i>O</i>-demethylation reactions using <i>Cunninghamella echinulata</i> NRRL 1384. ENZYME AND MICROBIAL TECHNOLOGY, 33(5), 743-748. doi:10.1016/S0141-0229(03)00207-2

DOI
10.1016/S0141-0229(03)00207-2
Journal article

The synthesis of potential buprenorphine intermediates by regioselective microbial N- and O-demethylation reactions using Cunnighamella echinulata NRRL 1384

Abel, A. M., Carnell, A. J., Davis, J. A., & Paylor, M. (2003). The synthesis of potential buprenorphine intermediates by regioselective microbial N- and O-demethylation reactions using Cunnighamella echinulata NRRL 1384. Enzyme and Microbial Technology, 33, 742-747.

Journal article

2002

Desymmetrisation of prochiral ketones using lipases

Carnell, A. J. (2002). Desymmetrisation of prochiral ketones using lipases. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 19, 83-92. doi:10.1016/S1381-1177(02)00154-6

DOI
10.1016/S1381-1177(02)00154-6
Journal article

A novel regiospecific <i>N</i> to <i>O</i>-methyl transferase activity in the biotransformation of a thebaine derivative with <i>Cunninghamella echinulata</i> NRRL 1384

Abel, A. M., Allan, G. R., Carnell, A. J., & Davis, J. A. (2002). A novel regiospecific <i>N</i> to <i>O</i>-methyl transferase activity in the biotransformation of a thebaine derivative with <i>Cunninghamella echinulata</i> NRRL 1384. CHEMICAL COMMUNICATIONS, (16), 1762-1763. doi:10.1039/b204697k

DOI
10.1039/b204697k
Journal article

Synthesis of potential buprenorphine intermediates by selective microbial <i>N</i>- and <i>O</i>-demethylation

Abel, A. M., Carnell, A. J., Davis, J. A., & Paylor, M. (2002). Synthesis of potential buprenorphine intermediates by selective microbial <i>N</i>- and <i>O</i>-demethylation. BIOTECHNOLOGY LETTERS, 24(15), 1291-1294. doi:10.1023/A:1016218211300

DOI
10.1023/A:1016218211300
Journal article

2001

Microbial deracemization of 1-aryl and 1-heteroaryl secondary alcohols

Allan, G. R., & Carnell, A. J. (2001). Microbial deracemization of 1-aryl and 1-heteroaryl secondary alcohols. JOURNAL OF ORGANIC CHEMISTRY, 66(19), 6495-6497. doi:10.1021/jo015770n

DOI
10.1021/jo015770n
Journal article

Chemoenzymatic synthesis of a tachykinin NK-2 antagonist

Allan, G., Carnell, A. J., Hernandez, M. L. E., & Pettman, A. (2001). Chemoenzymatic synthesis of a tachykinin NK-2 antagonist. TETRAHEDRON, 57(38), 8193-8202. doi:10.1016/S0040-4020(01)00796-7

DOI
10.1016/S0040-4020(01)00796-7
Journal article

One-pot deracemisation of an enol acetate derived from a prochiral cyclohexanone

Allan, G. R., Carnell, A. J., & Kroutil, W. (2001). One-pot deracemisation of an enol acetate derived from a prochiral cyclohexanone. TETRAHEDRON LETTERS, 42(34), 5959-5962. doi:10.1016/S0040-4039(01)01156-X

DOI
10.1016/S0040-4039(01)01156-X
Journal article

2000

Desymmetrisation of 4,4-disubstituted cyclohexanones by enzyme-catalysed resolution of their enol acetates

Allan, G., Carnell, A. J., Hernandez, M. L. E., & Pettman, A. (2000). Desymmetrisation of 4,4-disubstituted cyclohexanones by enzyme-catalysed resolution of their enol acetates. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, (20), 3382-3388. doi:10.1039/b005466f

DOI
10.1039/b005466f
Journal article

Chemoenzymatic synthesis of a non-peptide tachykinin NK-2 antagonist

Carnell, A. J., Hernandez, M. L. E., Pettman, A., & Bickley, J. F. (2000). Chemoenzymatic synthesis of a non-peptide tachykinin NK-2 antagonist. TETRAHEDRON LETTERS, 41(35), 6929-6933. doi:10.1016/S0040-4039(00)01149-7

DOI
10.1016/S0040-4039(00)01149-7
Journal article

2-Bromocyclohexanone perhydrat - X-ray crystal structure and conformational effects on reactivity in sulfoxidations

Carnell, A. J., Clegg, W., Johnstone, R. A. W., Parsy, C. C., & Sanderson, W. R. (2000). 2-Bromocyclohexanone perhydrat - X-ray crystal structure and conformational effects on reactivity in sulfoxidations. TETRAHEDRON, 56(35), 6571-6575. doi:10.1016/S0040-4020(00)00608-6

DOI
10.1016/S0040-4020(00)00608-6
Journal article

1999

Chiral enol acetates derived from prochiral oxabicyclic ketones using enzymes

Carnell, A. J., Swain, S. A., & Bickley, J. F. (1999). Chiral enol acetates derived from prochiral oxabicyclic ketones using enzymes. TETRAHEDRON LETTERS, 40(49), 8633-8636. doi:10.1016/S0040-4039(99)01809-2

DOI
10.1016/S0040-4039(99)01809-2
Journal article

<i>N</i>,<i>N</i>-dialkylalloxans -: a new class of catalyst for dioxirane epoxidations

Carnell, A. J., Johnstone, R. A. W., Parsey, C. C., & Sanderson, W. R. (1999). <i>N</i>,<i>N</i>-dialkylalloxans -: a new class of catalyst for dioxirane epoxidations. TETRAHEDRON LETTERS, 40(45), 8029-8032. doi:10.1016/S0040-4039(99)01610-X

DOI
10.1016/S0040-4039(99)01610-X
Journal article

Chapter 2. Synthetic methods

Carnell, A. J. (1999). Chapter 2. Synthetic methods. Annual Reports Section "B" (Organic Chemistry), 95, 39-58. doi:10.1039/a808596j

DOI
10.1039/a808596j
Journal article

Microbial transformation of (+)-10β,14-dihydroxy-<i>allo</i>-aromadendrane and (-)-<i>allo</i>-aromadendrone

de Lima, D. P., Carnell, A. J., & Roberts, S. M. (1999). Microbial transformation of (+)-10β,14-dihydroxy-<i>allo</i>-aromadendrane and (-)-<i>allo</i>-aromadendrone. JOURNAL OF CHEMICAL RESEARCH-S, (6), 396-397. doi:10.1039/a901226e

DOI
10.1039/a901226e
Journal article

Stereoinversions using microbial redox-reactions.

Carnell, A. J. (1999). Stereoinversions using microbial redox-reactions.. Advances in biochemical engineering/biotechnology, 63, 57-72. doi:10.1007/3-540-69791-8_3

DOI
10.1007/3-540-69791-8_3
Journal article

1998

2 Synthetic methods: Part (iii) Enzyme chemistry

Carnell, A. J. (1998). 2 Synthetic methods: Part (iii) Enzyme chemistry. Annual Reports on the Progress of Chemistry - Section B, 94, 39-49.

Journal article

Biocatalysis of deracemization in 1,2-diols

Page, P. C. B., Carnell, A. J., & McKenzie, M. J. (1998). Biocatalysis of deracemization in 1,2-diols. SYNLETT, (7), 774-776. Retrieved from https://www.webofscience.com/

Journal article

1997

Putting microbes to work

Carnell, A., & Roberts, S. (1997). Putting microbes to work. CHEMISTRY IN BRITAIN, 33(5), 49-51. Retrieved from https://www.webofscience.com/

Journal article

Desymmetrisation of prochiral ketones by catalytic enantioselective hydrolysis of their enol esters using enzymes.

Carnell, A. J., Barkley, J., & Singh, A. (1997). Desymmetrisation of prochiral ketones by catalytic enantioselective hydrolysis of their enol esters using enzymes.. TETRAHEDRON LETTERS, 38(44), 7781-7784. doi:10.1016/S0040-4039(97)01817-0

DOI
10.1016/S0040-4039(97)01817-0
Journal article

Total synthesis of (-)-reserpine using the chiron approach

Hanessian, S., Pan, J. W., Carnell, A., Bouchard, H., & Lesage, L. (1997). Total synthesis of (-)-reserpine using the chiron approach. JOURNAL OF ORGANIC CHEMISTRY, 62(3), 465-473. doi:10.1021/jo961713w

DOI
10.1021/jo961713w
Journal article

1994

PREPARATION OF OPTICALLY-ACTIVE CYCLOHEXANEDIOLS AND (+)-ALPHA-HYDROXYCYCLOHEPTANONE BY AN ENZYME-CATALYZED STEREOINVERSION/OXIDATION PROCESS

CARNELL, A. J., IACAZIO, G., ROBERTS, S. M., & WILLETTS, A. J. (1994). PREPARATION OF OPTICALLY-ACTIVE CYCLOHEXANEDIOLS AND (+)-ALPHA-HYDROXYCYCLOHEPTANONE BY AN ENZYME-CATALYZED STEREOINVERSION/OXIDATION PROCESS. TETRAHEDRON LETTERS, 35(2), 331-334. doi:10.1016/S0040-4039(00)76545-2

DOI
10.1016/S0040-4039(00)76545-2
Journal article

SYNTHESIS OF (+)-BREFELDIN-A

CARNELL, A. J., CASY, G., GORINS, G., KOMPANYSAEID, A., MCCAGUE, R., OLIVO, H. F., . . . WILLETTS, A. J. (1994). SYNTHESIS OF (+)-BREFELDIN-A. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, (23), 3431-3439. doi:10.1039/p19940003431

DOI
10.1039/p19940003431
Journal article

1992

BIOTRANSFORMATIONS BY FUNGI - REGIOSELECTIVE PLUS STEREOSELECTIVE BAEYER-VILLIGER OXIDATIONS BY DEMATIACEOUS FUNGI

CARNELL, A., & WILLETTS, A. (1992). BIOTRANSFORMATIONS BY FUNGI - REGIOSELECTIVE PLUS STEREOSELECTIVE BAEYER-VILLIGER OXIDATIONS BY DEMATIACEOUS FUNGI. BIOTECHNOLOGY LETTERS, 14(1), 17-20. doi:10.1007/BF01030907

DOI
10.1007/BF01030907
Journal article

1991

MICROBIAL OXIDATION OF 7ENDO-METHYLBICYCLO[3.2.0]HEPT-2-EN-6-ONE, 7,7-DIMETHYLBICYCLO[3.2.0]HEPT-2-EN-6-ONE AND 2EXO-BROMO-3ENDO-HYDROXY-7,7-DIMETHYLBICYCLO[3.2.0]HEPTAN-6-ONE USING ACINETOBACTER NCIMB-9871

CARNELL, A. J., ROBERTS, S. M., SIK, V., & WILLETTS, A. J. (1991). MICROBIAL OXIDATION OF 7ENDO-METHYLBICYCLO[3.2.0]HEPT-2-EN-6-ONE, 7,7-DIMETHYLBICYCLO[3.2.0]HEPT-2-EN-6-ONE AND 2EXO-BROMO-3ENDO-HYDROXY-7,7-DIMETHYLBICYCLO[3.2.0]HEPTAN-6-ONE USING ACINETOBACTER NCIMB-9871. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, (10), 2385-2389. doi:10.1039/p19910002385

DOI
10.1039/p19910002385
Journal article

1990

BIOTRANSFORMATION OF CYCLOALKENONES BY FUNGI - BAEYER-VILLIGER OXIDATION OF BICYCLOHEPTENONE BY DEMATIACEOUS FUNGI

CARNELL, A., & WILLETTS, A. (1990). BIOTRANSFORMATION OF CYCLOALKENONES BY FUNGI - BAEYER-VILLIGER OXIDATION OF BICYCLOHEPTENONE BY DEMATIACEOUS FUNGI. BIOTECHNOLOGY LETTERS, 12(12), 885-890. doi:10.1007/BF01022584

DOI
10.1007/BF01022584
Journal article

ENZYME-CATALYZED BAEYER-VILLIGER OXIDATIONS OF SOME SUBSTITUTED BICYCLO[3.2.0]HEPTANONES

CARNELL, A. J., ROBERTS, S. M., SIK, V., & WILLETTS, A. J. (1990). ENZYME-CATALYZED BAEYER-VILLIGER OXIDATIONS OF SOME SUBSTITUTED BICYCLO[3.2.0]HEPTANONES. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, (20), 1438-1439. doi:10.1039/c39900001438

DOI
10.1039/c39900001438
Journal article