Publications
2024
Role of Transporters and Enzymes in Metabolism and Distribution of 4-Chlorokynurenine (AV-101).
Patel, W., Shankar, R. G., Smith, M. A., Snodgrass, H. R., Pirmohamed, M., Jorgensen, A. L., . . . Dickens, D. (2024). Role of Transporters and Enzymes in Metabolism and Distribution of 4-Chlorokynurenine (AV-101).. Molecular pharmaceutics. doi:10.1021/acs.molpharmaceut.3c00700
Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis.
Monangi, N. K., Xu, H., Fan, Y. -M., Khanam, R., Khan, W., Deb, S., . . . Muglia, L. J. (2024). Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis.. The American journal of clinical nutrition, 119(1), 221-231. doi:10.1016/j.ajcnut.2023.10.011
2023
The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury
Ball, A. L., Jolly, C. E., Lennon, M. G., Lyon, J. J., Alfirevic, A., & Chadwick, A. E. (2023). The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury. ELIFE, 12. doi:10.7554/eLife.78187
Developing In Vitro Models to Define the Role of Direct Mitochondrial Toxicity in Frequently Reported Drug-Induced Rhabdomyolysis
Bin Dayel, F. F., Alfirevic, A., & Chadwick, A. E. (2023). Developing In Vitro Models to Define the Role of Direct Mitochondrial Toxicity in Frequently Reported Drug-Induced Rhabdomyolysis. Biomedicines, 11(5), 1485. doi:10.3390/biomedicines11051485
Characterization of Drug-Specific CD4+T-Cells Reveals Possible Roles of HLA Class II in the Pathogenesis of Carbamazepine Hypersensitivity Reactions
Jaruthamsophon, K., Thomson, P. J., Hammond, S., Zhang, E., Alfirevic, A., Sukasem, C., . . . Pirmohamed, M. (2023). Characterization of Drug-Specific CD4+T-Cells Reveals Possible Roles of HLA Class II in the Pathogenesis of Carbamazepine Hypersensitivity Reactions. CHEMICAL RESEARCH IN TOXICOLOGY. doi:10.1021/acs.chemrestox.2c00414
Editorial: Emerging talents in frontiers in pharmacology: pharmacogenetics and pharmacogenomics 2022.
Klomp, S. D., & Alfirevic, A. (2023). Editorial: Emerging talents in frontiers in pharmacology: pharmacogenetics and pharmacogenomics 2022.. Frontiers in pharmacology, 14, 1307602. doi:10.3389/fphar.2023.1307602
2022
Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multi-country meta-analysis
Platelet response to aspirin in UK and Irish pregnancy cohorts: a genome-wide approach
Mone, F., Gupta, J. K., Phelan, M. M., Meher, S., Lian, L. Y., Francis, B., . . . Navaratnam, K. (2022). Platelet response to aspirin in UK and Irish pregnancy cohorts: a genome-wide approach. PLATELETS, 33(6), 911-917. doi:10.1080/09537104.2021.2007872
Socioeconomic and health factors related to polypharmacy and medication management: analysis of a Household Health Survey in North West Coast England
Downing, J., Taylor, R., Mountain, R., Barr, B., Daras, K., Comerford, T., . . . Alfirevic, A. (2022). Socioeconomic and health factors related to polypharmacy and medication management: analysis of a Household Health Survey in North West Coast England. BMJ Open, 12(5), e054584. doi:10.1136/bmjopen-2021-054584
Systematic review of preterm birth multi-omic biomarker studies
Gupta, J. K., & Alfirevic, A. (2022). Systematic review of preterm birth multi-omic biomarker studies. EXPERT REVIEWS IN MOLECULAR MEDICINE, 24. doi:10.1017/erm.2022.13
The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury: a translational <i>in vitro</i> study
Genome and transcriptome profiling of spontaneous preterm birth phenotypes (vol 12, 1003, 2022)
Gupta, J. K., Care, A., Goodfellow, L., Alfirevic, Z., Muller-Myhsok, B., & Alfirevic, A. (2022). Genome and transcriptome profiling of spontaneous preterm birth phenotypes (vol 12, 1003, 2022). SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-06338-w
Genome and transcriptome profiling of spontaneous preterm birth phenotypes
Gupta, J. K., Care, A., Goodfellow, L., Alfirevic, Z., Muller-Myhsok, B., & Alfirevic, A. (2022). Genome and transcriptome profiling of spontaneous preterm birth phenotypes. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-04881-0
2021
Vaginal bacterial load in the second trimester is associated with early preterm birth recurrence: a nested case-control study
Goodfellow, L., Verwijs, M. C., Care, A., Sharp, A., Ivandic, J., Poljak, B., . . . van de Wijgert, J. H. H. M. (2021). Vaginal bacterial load in the second trimester is associated with early preterm birth recurrence: a nested case-control study. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 128(13), 2061-2072. doi:10.1111/1471-0528.16816
Metabolic profiling of maternal serum of women a high-risk of spontaneous preterm birth using NMR and MGWAS approach
Gupta, J. K., Care, A., Goodfellow, L., Alfirevic, Z., Lian, L. -Y., Mueller-Myhsok, B., . . . Phelan, M. M. (2021). Metabolic profiling of maternal serum of women a high-risk of spontaneous preterm birth using NMR and MGWAS approach. BIOSCIENCE REPORTS, 41(9). doi:10.1042/BSR20210759
Association of maternal prenatal selenium concentration and preterm birth: a multicountry meta-analysis
Monangi, N., Xu, H., Khanam, R., Khan, W., Deb, S., Pervin, J., . . . Consortium, I. -S. S. (2021). Association of maternal prenatal selenium concentration and preterm birth: a multicountry meta-analysis. BMJ GLOBAL HEALTH, 6(9). doi:10.1136/bmjgh-2021-005856
Deciphering Adverse Drug Reactions: <i>In Vitro</i> Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01
Ogese, M. O., Lister, A., Gardner, J., Meng, X., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2021). Deciphering Adverse Drug Reactions: <i>In Vitro</i> Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01. TOXICOLOGICAL SCIENCES, 183(1), 139-153. doi:10.1093/toxsci/kfab084
Maternal selenium levels and whole genome screen in recurrent spontaneous preterm birth population: a nested case control study
Care, A. G., Gupta, J. K., Goodfellow, L., Zhang, G., Monangi, N., Belling, E., . . . Alfirevic, Z. (2021). Maternal selenium levels and whole genome screen in recurrent spontaneous preterm birth population: a nested case control study. European Journal of Obstetrics & Gynecology and Reproductive Biology. doi:10.1016/j.ejogrb.2021.08.015
The Role of Mitochondrial DNA Variation in Drug Response: A Systematic Review
Jones, S. W., Ball, A. L., Chadwick, A. E., & Alfirevic, A. (n.d.). The Role of Mitochondrial DNA Variation in Drug Response: A Systematic Review. Frontiers in Genetics, 12. doi:10.3389/fgene.2021.698825
Plasma long-chain omega-3 fatty acid status and risk of recurrent early spontaneous preterm birth: a prospective observational study
Goodfellow, L., Care, A., Harrold, J., Sharp, A., Ivandic, J., Poljak, B., . . . Alfirevic, Z. (2021). Plasma long-chain omega-3 fatty acid status and risk of recurrent early spontaneous preterm birth: a prospective observational study. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 100(8), 1401-1411. doi:10.1111/aogs.14147
Assessing measures of aspirin adherence in pregnancy: Secondary analysis of the TEST randomized controlled trial
Mone, F., Mulcahy, C., Navaratnam, K., Phelan, M. M., Breathnach, F., Alfirevic, A., & McAuliffe, F. M. (2021). Assessing measures of aspirin adherence in pregnancy: Secondary analysis of the TEST randomized controlled trial. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 259, 222-223. doi:10.1016/j.ejogrb.2020.11.058
Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers
Ball, A. L., Bloch, K. M., Rainbow, L., Liu, X., Kenny, J., Lyon, J. J., . . . Chadwick, A. E. (n.d.). Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers. Archives of Toxicology. doi:10.1007/s00204-021-02988-3
Vaginal bacterial load in the second trimester is associated with early preterm birth recurrence: a nested case-control study
Goodfellow, L., Verwijs, M., Care, A., Sharp, A., Ivandic, J., Poljak, B., . . . van de Wijgert, J. H. H. M. (2021). Vaginal bacterial load in the second trimester is associated with early preterm birth recurrence: a nested case-control study. doi:10.1101/2021.01.14.21249680
Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex
Patel, W., Rimmer, L., Smith, M., Moss, L., Smith, M. A., Snodgrass, H. R., . . . Dickens, D. (2021). Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex. MOLECULAR PHARMACEUTICS, 18(1), 113-123. doi:10.1021/acs.molpharmaceut.0c00727
An assessment of drug-induced rhabdomyolysis cases within the US Food and Drug Administration Adverse Event Reporting System
Bin Dayel, F., Alfirevic, A., Turner, R., & Chadwick, A. (2021). An assessment of drug-induced rhabdomyolysis cases within the US Food and Drug Administration Adverse Event Reporting System. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 87 (pp. 1617-1618). Retrieved from https://www.webofscience.com/
Identification of early pregnancy metabolomic biomarkers of women at high-risk of preterm birth using NMR and mGWAS
Gupta, J., Care, A., Goodfellow, L., Alfirevic, Z., Lian, L. -Y., Muller-Myhsok, B., . . . Phelan, M. (2021). Identification of early pregnancy metabolomic biomarkers of women at high-risk of preterm birth using NMR and mGWAS. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 178 (pp. 432-433). Retrieved from https://www.webofscience.com/
Probenecid increases the concentration of 7-chlorokynurenic acid derived from the prodrug 4-chlorokynurenine within the prefrontal cortex
Patel, W., Rimmer, L., Smith, M., Moss, L., Smith, M., Snodgrass, R., . . . Dickens, D. (2021). Probenecid increases the concentration of 7-chlorokynurenic acid derived from the prodrug 4-chlorokynurenine within the prefrontal cortex. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 178 (pp. 463). Retrieved from https://www.webofscience.com/
2020
Examining the uptake of predictive BRCA testing in the UK; findings and implications
Martin, A., Downing, J., Collins, B., Godman, B., Alfirevic, A., Greenhalgh, L., & Pirmohamed, M. (2020). Examining the uptake of predictive BRCA testing in the UK; findings and implications. European Journal of Human Genetics, 2020. doi:10.1038/s41431-020-00783-9
Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment
Rasmussen, E. R., Hallberg, P., Baranova, E. V., Eriksson, N., Karawajczyk, M., Johansson, C., . . . Wadelius, M. (2020). Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment. PHARMACOGENOMICS JOURNAL, 20(6), 770-783. doi:10.1038/s41397-020-0165-2
Characterization of Clozapine-Responsive Human T Cells
Ogese, M. O., Lister, A., Jenkins, R. E., Meng, X., Alfirevic, A., Douglas, L., . . . Naisbitt, D. J. (2020). Characterization of Clozapine-Responsive Human T Cells. JOURNAL OF IMMUNOLOGY, 205(9), 2375-+. doi:10.4049/jimmunol.2000646
Safety perspectives on presently considered drugs for the treatment of COVID‐19
Penman, S. L., Kiy, R. T., Jensen, R. L., Beoku‐Betts, C., Alfirevic, A., Back, D., . . . Chadwick, A. E. (n.d.). Safety perspectives on presently considered drugs for the treatment of COVID‐19. British Journal of Pharmacology. doi:10.1111/bph.15204
The longitudinal NIHR ARC North West Coast Household Health Survey: Exploring health inequalities in disadvantaged communities
Giebel, C., McIntyre, J., Alfirevic, A., Corcoran, R., Daras, K., Downing, J., . . . Barr, B. (2020). The longitudinal NIHR ARC North West Coast Household Health Survey: Exploring health inequalities in disadvantaged communities. BMC Public Health, 20. doi:10.1186/s12889-020-09346-5
Pharmacogenetics and statin-related myopathy: what do we know?
Turner, R. M., Radman, I., Bozina, N., & Alfirevic, A. (2020). Pharmacogenetics and statin-related myopathy: what do we know?. PHARMACOGENOMICS, 21(12), 821-825. doi:10.2217/pgs-2020-0041
Exome Sequencing Reveals Common and Rare Variants in F5 Associated With ACE Inhibitor and Angiotensin Receptor Blocker–Induced Angioedema
Maroteau, C., Siddiqui, M. K., Veluchamy, A., Carr, F., White, M., Cassidy, A. J., . . . PREDICTION-ADR. (2020). Exome Sequencing Reveals Common and Rare Variants in F5 Associated With ACE Inhibitor and Angiotensin Receptor Blocker–Induced Angioedema. CLINICAL PHARMACOLOGY & THERAPEUTICS. doi:10.1002/cpt.1927
Safety perspectives on presently considered drugs for the treatment of COVID-19
Has the introduction of direct oral anticoagulants (DOACs) in England increased emergency admissions for bleeding conditions? A longitudinal ecological study
Alfirevic, A., Downing, J., Daras, K., Comerford, T., Pirmohamed, M., & Barr, B. (2020). Has the introduction of direct oral anticoagulants (DOACs) in England increased emergency admissions for bleeding conditions? A longitudinal ecological study. BMJ Open, 10(5). doi:10.1136/bmjopen-2019-033357
Genetic associations with clozapine-induced myocarditis in patients with schizophrenia
Lacaze, P., Ronaldson, K. J., Zhang, E. J., Alfirevic, A., Shah, H., Newman, L., . . . Pirmohamed, M. (2020). Genetic associations with clozapine-induced myocarditis in patients with schizophrenia. TRANSLATIONAL PSYCHIATRY, 10(1). doi:10.1038/s41398-020-0722-0
Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools
Gonzalez-Galarza, F. F., McCabe, A., Santos, E. J. M. D., Jones, J., Takeshita, L., Ortega-Rivera, N. D., . . . Jones, A. R. (n.d.). Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools. Nucleic Acids Research. doi:10.1093/nar/gkz1029
The antidepressant AV-101 is a substrate for LAT1 (SLC7A5) at the blood-brain barrier
Patel, W., Smith, M., Snodgrass, R., Pirmohamed, M., Alfirevic, A., & Dickens, D. (2020). The antidepressant AV-101 is a substrate for LAT1 (SLC7A5) at the blood-brain barrier. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 177 (pp. 2621-2622). Retrieved from https://www.webofscience.com/
2019
Genomewide Association Study of Statin‐Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink
Carr, D. (2019). Genomewide Association Study of Statin‐Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink. Clinical Pharmacology and Therapeutics, 106(6), 1353-1361. doi:10.1002/cpt.1557
PBI60 TRENDS AND UPTAKE OF PREDICTIVE BRCA TESTING
Martin, A., Pedra, G., Downing, J., Godman, B., Alfirevic, A., Greenhalgh, K. L., & Pirmohamed, M. (2019). PBI60 TRENDS AND UPTAKE OF PREDICTIVE BRCA TESTING. Value in Health, 22, S428. doi:10.1016/j.jval.2019.09.164
Trends in <i>BRCA</i> testing and socioeconomic deprivation
Martin, A. P., Pedra, G., Downing, J., Collins, B., Godman, B., Alfirevic, A., . . . Greenhalgh, K. L. (2019). Trends in <i>BRCA</i> testing and socioeconomic deprivation. EUROPEAN JOURNAL OF HUMAN GENETICS, 27(9), 1351-1360. doi:10.1038/s41431-019-0424-3
Public involvement in the dissemination of the North West Coast Household Health Survey: Experiences and lessons of co-producing research together
Giebel, C., Hassan, S., McIntyre, J. C., Corcoran, R., Barr, B., Gabbay, M., . . . Alfirevic, A. (2019). Public involvement in the dissemination of the North West Coast Household Health Survey: Experiences and lessons of co-producing research together. HEALTH EXPECTATIONS, 22(4), 643-649. doi:10.1111/hex.12940
Genetic testing for prevention of severe drug-induced skin rash.
Alfirevic, A., Pirmohamed, M., Marinovic, B., Harcourt-Smith, L., Jorgensen, A. L., & Cooper, T. E. (2019). Genetic testing for prevention of severe drug-induced skin rash.. The Cochrane Database of Systematic Reviews, 7, CD010891. doi:10.1002/14651858.cd010891.pub2
Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing.
Floyd, J. S., Bloch, K. M., Brody, J. A., Maroteau, C., Siddiqui, M. K., Gregory, R., . . . PREDICTION-ADR Consortium and EUDRAGENE. (2019). Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing.. PLoS One, 14(6). doi:10.1371/journal.pone.0218115
Shared genetic risk factors across carbamazepine-induced hypersensitivity reactions.
Nicoletti, P., Barrett, S., McEvoy, L., Daly, A. K., Aithal, G., Lucena, M. I., . . . Pirmohamed, M. (2019). Shared genetic risk factors across carbamazepine-induced hypersensitivity reactions.. Clinical pharmacology and therapeutics, 106(5), 1028-1036. doi:10.1002/cpt.1493
Trends in BRCA testing over time and socioeconomic deprivation
Martin, A. P., Pedra, G., Downing, J., Collins, B., Godman, B., Alfirevic, A., . . . Greenhalgh, K. L. (n.d.). Trends in BRCA testing over time and socioeconomic deprivation. European Journal of Human Genetics. doi:10.1038/s41431-019-0424-3
Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study
Jorgensen, A. L., Prince, C., Fitzgerald, G., Hanson, A., Downing, J., Reynolds, J., . . . Pirmohamed, M. (2019). Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study. BMC Medicine, 17. doi:10.1186/s12916-019-1308-7
What are the social predictors of accident and emergency attendance in disadvantaged neighbourhoods? Results from a cross-sectional household health survey in the north west of England
Giebel, C., McIntyre, J. C., Daras, K., Gabbay, M., Downing, J., Pirmohamed, M., . . . Barr, B. (2019). What are the social predictors of accident and emergency attendance in disadvantaged neighbourhoods? Results from a cross-sectional household health survey in the north west of England. BMJ Open, 9(1). doi:10.1136/bmjopen-2018-022820
Aspirin nonresponsiveness in pregnant women at high risk of pre-eclampsia
Navaratnam, K., Agarwal, U., Alfirevic, A., & Alfirevic, Z. (2019). Aspirin nonresponsiveness in pregnant women at high risk of pre-eclampsia. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 126 (pp. 4). Retrieved from https://www.webofscience.com/
Processes and barriers to implementation of point-of-care genotype-guided dosing of warfarin into UK outpatient anticoagulation clinics
Fitzgerald, G., Prince, C., Downing, J., Reynolds, J., Zhang, J. E., Hanson, A., . . . Pirmohamed, M. (2019). Processes and barriers to implementation of point-of-care genotype-guided dosing of warfarin into UK outpatient anticoagulation clinics. PHARMACOGENOMICS, 20(8), 599-608. doi:10.2217/pgs-2019-0021
TRENDS AND UPTAKE OF PREDICTIVE <i>BRCA</i> TESTING
Martin, A., Pedra, G., Downing, J., Godman, B., Alfirevic, A., Greenhalgh, K. L., & Pirmohamed, M. (2019). TRENDS AND UPTAKE OF PREDICTIVE <i>BRCA</i> TESTING. In VALUE IN HEALTH Vol. 22 (pp. S428). Retrieved from https://www.webofscience.com/
2018
PCN254 - TRENDS IN BRCA TESTING OVER TIME AND SOCIOECONOMIC DEPRIVATION
Martin, A., Pedra, G. G., Downing, J., Collins, B., Godman, B., Alfirevic, A., . . . Greenhalgh, K. L. (2018). PCN254 - TRENDS IN BRCA TESTING OVER TIME AND SOCIOECONOMIC DEPRIVATION. Value in Health, 21, S57. doi:10.1016/j.jval.2018.09.336
Trastuzumab uptake in HER2-positive breast cancer patients: a systematic review and meta-analysis of observational studies
Martin, A. P., Downing, J., Cochrane, M., Collins, B., Francis, B., Haycox, A., . . . Pirmohamed, M. (2018). Trastuzumab uptake in HER2-positive breast cancer patients: a systematic review and meta-analysis of observational studies. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 130, 92-107. doi:10.1016/j.critrevonc.2018.07.012
Generation of a novel, personalised in vitro model to assess the impact of mitochondrial DNA variation upon bioenergetic function and susceptibility to hepatotoxicity
Ball, A., Alfirevic, A., Lyon, J., & Chadwick, A. (2018). Generation of a novel, personalised in vitro model to assess the impact of mitochondrial DNA variation upon bioenergetic function and susceptibility to hepatotoxicity. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1859, e113. doi:10.1016/j.bbabio.2018.09.334
TRASTUZUMAB UPTAKE IN HER2-POSITIVE BREAST CANCER PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF OBSERVATIONAL STUDIES
Martin, A. P., Downing, J., Collins, B., Cochrane, M., Francis, B., Haycox, A., . . . Pirmohamed, M. (2018). TRASTUZUMAB UPTAKE IN HER2-POSITIVE BREAST CANCER PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF OBSERVATIONAL STUDIES. In VALUE IN HEALTH Vol. 21 (pp. S43). doi:10.1016/j.jval.2018.04.248
Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity
Usui, T., Faulkner, L., Farrell, J., French, N. S., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2018). Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity. CHEMICAL RESEARCH IN TOXICOLOGY, 31(3), 165-167. doi:10.1021/acs.chemrestox.8b00030
Genetic factors and response to low dose aspirin in pregnancy
Alfirevic, A., Navaratnam, K., Alfirevic, Z., & Zhang, E. (2018). Genetic factors and response to low dose aspirin in pregnancy. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 125 (pp. 104-105). Retrieved from https://www.webofscience.com/
The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017)
Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2018). The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1951. doi:10.4049/jimmunol.1800019
Aspirin non-responsiveness in pregnant women at high-risk of pre-eclampsia
Navaratnam, K., Alfirevic, A., Jorgensen, A., & Alfirevic, Z. (2018). Aspirin non-responsiveness in pregnant women at high-risk of pre-eclampsia. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 221, 144-150. doi:10.1016/j.ejogrb.2017.12.052
Evaluating assessments of aspirin adherence in low-risk women for pre-eclampsia prevention: A comparison of crude and objective measures
Mone, F., Phelan, M., Alfirevic, A., & McAuliffe, F. M. (2018). Evaluating assessments of aspirin adherence in low-risk women for pre-eclampsia prevention: A comparison of crude and objective measures. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 125 (pp. 66). Retrieved from https://www.webofscience.com/
2017
A common missense variant of LILRB5 is associated with statin intolerance and myalgia
Siddiqui, M. K., Maroteau, C., Veluchamy, A., Tornio, A., Tavendale, R., Carr, F., . . . Consortium, P. R. E. D. I. C. T. I. O. N. -A. D. R. (2017). A common missense variant of LILRB5 is associated with statin intolerance and myalgia. EUROPEAN HEART JOURNAL, 38(48), 3569-3U31. doi:10.1093/eurheartj/ehx467
HLA-A 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome-wide association study
Bluett, J., Owen, S. -A., Massey, J., Alfirevic, A., Pirmohamed, M., Plant, D., . . . Barton, A. (2017). HLA-A 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome-wide association study. ANNALS OF THE RHEUMATIC DISEASES, 76(12). doi:10.1136/annrheumdis-2017-211512
How important is aspirin adherence when evaluating effectiveness of low-dose aspirin?
Navaratnam, K., Alfirevic, Z., Pirmohamed, M., & Alfirevic, A. (2017). How important is aspirin adherence when evaluating effectiveness of low-dose aspirin?. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 219, 1-9. doi:10.1016/j.ejogrb.2017.10.004
An assessment of the impact of pharmacogenomics on health disparities: a systematic literature review
Martin, A., Downing, J., Maden, M., Fleeman, N., Alfirevic, A., Haycox, A., & Pirmohamed, M. (2017). An assessment of the impact of pharmacogenomics on health disparities: a systematic literature review. PHARMACOGENOMICS, 18(16), 1541-1550. doi:10.2217/pgs-2017-0076
Whole exome sequencing in individuals with statin-induced myopathy
Bloch, K. M., Carr, D., Pirmohamed, M., Morris, A., Maroteau, C., Eriksson, N., . . . Alfirevic, A. (2017). Whole exome sequencing in individuals with statin-induced myopathy. In DRUG SAFETY Vol. 40 (pp. 1026). Retrieved from https://www.webofscience.com/
Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout
Plumpton, C. O., Alfirevic, A., Pirmohamed, M., & Hughes, D. A. (2017). Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout. Rheumatology (Oxford, England), 56(10), 1729-1739. doi:10.1093/rheumatology/kex253
Patient ethnicity and the risk of immune-mediated adverse drug reactions
Alfirevic, A. (2017). Patient ethnicity and the risk of immune-mediated adverse drug reactions. PHARMACOGENOMICS, 18(15), 1375-1378. doi:10.2217/pgs-2017-0124
Evaluation of agreement of placental growth factor (PlGF) tests and the soluble FMS-like tyrosine kinase 1 (sFlt - 1)/PlGF ratio, comparison of predictive accuracy for preeclampsia, and relation to uterine artery Doppler and response to aspirin
Navaratnam, K., Abreu, P., Clarke, H., Jorgensen, A., Alfirevic, A., & Alfirevic, Z. (2017). Evaluation of agreement of placental growth factor (PlGF) tests and the soluble FMS-like tyrosine kinase 1 (sFlt - 1)/PlGF ratio, comparison of predictive accuracy for preeclampsia, and relation to uterine artery Doppler and response to aspirin. The Journal of Maternal-Fetal and Neonatal Medicine, 32(2), 179-187. doi:10.1080/14767058.2017.1373760
The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors
Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2017). The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors. JOURNAL OF IMMUNOLOGY, 199(4), 1223-1237. doi:10.4049/jimmunol.1602029
<i>CKM</i> Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia
Siddiqui, M. K., Veluchamy, A., Maroteau, C., Tavendale, R., Carr, F., Pearson, E., . . . Palmer, C. N. A. (2017). <i>CKM</i> Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia. CIRCULATION-CARDIOVASCULAR GENETICS, 10(4). doi:10.1161/CIRCGENETICS.117.001737
Effect of Genetic Variability in the <i>CYP4F2, CYP4F11</i>, and <i>CYP4F12</i> Genes on Liver mRNA Levels and Warfarin Response
Zhang, J. E., Klein, K., Jorgensen, A. L., Francis, B., Alfirevic, A., Bourgeois, S., . . . Pirmohamed, M. (2017). Effect of Genetic Variability in the <i>CYP4F2, CYP4F11</i>, and <i>CYP4F12</i> Genes on Liver mRNA Levels and Warfarin Response. FRONTIERS IN PHARMACOLOGY, 8. doi:10.3389/fphar.2017.00323
EXAMINATION OF EQUITY IN THE DELIVERY OF PERSONALISED MEDICINES
Martin, A. P., Haycox, A., Downing, J., Alfirevic, A., & Pirmohamed, M. (2016). EXAMINATION OF EQUITY IN THE DELIVERY OF PERSONALISED MEDICINES. In VALUE IN HEALTH Vol. 19 (pp. A266). doi:10.1016/j.jval.2016.03.771
Genome-Wide Association Study of Nevirapine Hypersensitivity in a sub-Saharan African HIV-infected Population
Carr, D. F., Bourgeois, S., Chaponda, M., Takeshita, L., Morris, A., Cornejo Castro, E. M., . . . Pirmohamed, M. (2017). Genome-Wide Association Study of Nevirapine Hypersensitivity in a sub-Saharan African HIV-infected Population. Journal of Antimicrobial Chemotherapy, 72(4), 1152-1162. doi:10.1093/jac/dkw545
Human leucocyte antigen-adverse drug reaction associations: from a perspective of ethnicity
Ghattaoraya, G. S., Middleton, D., Santos, E. J. M., Dickson, R., Jones, A. R., & Alfirevic, A. (2017). Human leucocyte antigen-adverse drug reaction associations: from a perspective of ethnicity. INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 44(01), 7-26. doi:10.1111/iji.12304
New Approaches to Investigate Drug-Induced Hypersensitivity
Ogese, M. O., Ahmed, S., Alferivic, A., Betts, C. J., Dickinson, A., Faulkner, L., . . . Naisbitt, D. J. (2017). New Approaches to Investigate Drug-Induced Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 30(1), 239-259. doi:10.1021/acs.chemrestox.6b00333
Generation of a novel, personalised in vitro model to assess the impact of mitochondrial DNA variation upon susceptibility to hepatotoxicity
Ball, A., Alfirevic, A., Lyon, J., & Chadwick, A. (2017). Generation of a novel, personalised in vitro model to assess the impact of mitochondrial DNA variation upon susceptibility to hepatotoxicity. In DRUG SAFETY Vol. 40 (pp. 1024-1025). Retrieved from https://www.webofscience.com/
Genomics of Adverse Drug Reactions
Alfirevic, A., & Pirmohamed, M. (2017). Genomics of Adverse Drug Reactions. TRENDS IN PHARMACOLOGICAL SCIENCES, 38(1), 100-109. doi:10.1016/j.tips.2016.11.003
2016
Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity
Faulkner, L., Gibson, A., Sullivan, A., Tailor, A., Usui, T., Alfirevic, A., . . . Park, B. K. (2016). Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity. TOXICOLOGICAL SCIENCES, 154(2), 416-429. doi:10.1093/toxsci/kfw177
Semi-systematic review of definitions and diagnostic tests for aspirin resistance: an opportunity to stratify prevention of placental disease
Navaratnam, K., Alfirevic, A., & Alfirevic, Z. (2016). Semi-systematic review of definitions and diagnostic tests for aspirin resistance: an opportunity to stratify prevention of placental disease. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 123 (pp. E10-E11). Retrieved from https://www.webofscience.com/
Identification of the additional mitochondrial liabilities of 2-hydroxyflutamide when compared to its parent compound, flutamide in HepG2 cells
Ball, A. L., Kamalian, L., Alfirevic, A., Chadwick, A. E., & Lyon, J. J. (2016). Identification of the additional mitochondrial liabilities of 2-hydroxyflutamide when compared to its parent compound, flutamide in HepG2 cells. Toxicological Sciences, 153(02), 341-351. doi:10.1093/toxsci/kfw126
Low dose aspirin and pregnancy: how important is aspirin resistance?
Navaratnam, K., Alfirevic, A., & Alfirevic, Z. (2016). Low dose aspirin and pregnancy: how important is aspirin resistance?. BJOG: an International Journal of Obstetrics and Gynaecology, 123(9), 1481-1487. doi:10.1111/1471-0528.13914
Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia.
Legge, S. E., Hamshere, M. L., Ripke, S., Pardinas, A. F., Goldstein, J. I., Rees, E., . . . Walters, J. T. R. (2017). Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia.. Molecular psychiatry, 22(10), 1502-1508. doi:10.1038/mp.2016.97
Pharmacogenetics and Pharmacogenomics
Alfirevic, A., & Pirmohamed, M. (2016). Pharmacogenetics and Pharmacogenomics. In Medical and Health Genomics (pp. 121-137). Elsevier. doi:10.1016/b978-0-12-420196-5.00010-1
A web resource for mining HLA associations with adverse drug reactions: HLA-ADR.
Ghattaoraya, G. S., Dundar, Y., González-Galarza, F. F., Maia, M. H. T., Santos, E. J. M., da Silva, A. L. S., . . . Jones, A. R. (2016). A web resource for mining HLA associations with adverse drug reactions: HLA-ADR.. Database : the journal of biological databases and curation, 2016, baw069. doi:10.1093/database/baw069
7th Drug hypersensitivity meeting: part two
Elera, J. D., Boteanu, C., Blanco, M. A. J., Gonzalez-Mendiola, R., García, I. C., Alvarez, A., . . . Santiago, T. L. (2016). 7th Drug hypersensitivity meeting: part two. Clinical and translational allergy, 6(Suppl 3).
Chapter 10 Pharmacogenetics and Pharmacogenomics
Alfirevic, A., & Pirmohamed, M. (2016). Chapter 10 Pharmacogenetics and Pharmacogenomics. In Medical and Health Genomics (pp. 121-137). Elsevier. doi:10.1016/b978-0-12-420196-5.00010-1
2015
HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis
Ogese, M. O., Saide, K., Faulkner, L., Whitaker, P., Peckham, D., Alfirevic, A., . . . Naisbitt, D. J. (2015). HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis. CLINICAL AND EXPERIMENTAL ALLERGY, 45(8), 1305-1316. doi:10.1111/cea.12546
121 Extended HLA analysis in a cohort of patients hypersensitive to beta-lactam antibiotics
Whitaker, P., Alfirevic, A., Etherington, C., Clifton, I., Fitch, G., Pirmohamed, M., & Peckham, D. (2015). 121 Extended HLA analysis in a cohort of patients hypersensitive to beta-lactam antibiotics. Journal of Cystic Fibrosis, 14, S88. doi:10.1016/s1569-1993(15)30298-8
Genetics of Immune-Mediated Adverse Drug Reactions: a Comprehensive and Clinical Review
Yip, V. L. M., Alfirevic, A., & Pirmohamed, M. (2015). Genetics of Immune-Mediated Adverse Drug Reactions: a Comprehensive and Clinical Review. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 48(2-3), 165-175. doi:10.1007/s12016-014-8418-y
Misoprostol-induced fever and genetic polymorphisms in drug transporters <i>SLCO1B1</i> and <i>ABCC4</i> in women of Latin American and European ancestry
Alfirevic, A., Durocher, J., Elati, A., Leon, W., Dickens, D., Raedisch, S., . . . Winikoff, B. (2015). Misoprostol-induced fever and genetic polymorphisms in drug transporters <i>SLCO1B1</i> and <i>ABCC4</i> in women of Latin American and European ancestry. PHARMACOGENOMICS, 16(9), 919-928. doi:10.2217/pgs.15.53
Cost‐effectiveness of screening for HLA ‐A *31:01 prior to initiation of carbamazepine in epilepsy
Plumpton, C. O., Yip, V. L. M., Alfirevic, A., Marson, A. G., Pirmohamed, M., & Hughes, D. A. (2015). Cost‐effectiveness of screening for HLA ‐A *31:01 prior to initiation of carbamazepine in epilepsy. EPILEPSIA, 56(04), 556-563. doi:10.1111/epi.12937
Su1978 Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy
O'Hara, A., Burkitt, M. D., Carr, D. F., Alfirevic, A., Moore, A. R., Murugesan, S. V., . . . Pritchard, D. M. (2015). Su1978 Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy. Gastroenterology, 148(4), S-566. doi:10.1016/s0016-5085(15)31907-7
HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta-analysis.
Cornejo Castro, E. M., Carr, D., Jorgensen, A., Alfirevic, A., & Pirmohamed, M. (2015). HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta-analysis.. Pharmacogenetics and genomics, 25(04), 186-198. doi:10.1097/FPC.0000000000000124
Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses
Gibson, A., Faulkner, L., Ogese, M., Lichtenfels, M., Esser, P., Martin, S., . . . Naisbitt, D. (2015). Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses. In ALLERGY Vol. 70 (pp. 26). Retrieved from https://www.webofscience.com/
Polymorphisms in the <i>RELB</i> Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy
O'Hara, A., Burkitt, M. D., Carr, D. F., Alfirevic, A., Moore, A. R., Murugesan, S. V., . . . Pritchard, D. M. (2015). Polymorphisms in the <i>RELB</i> Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy. In GASTROENTEROLOGY Vol. 148 (pp. S566). Retrieved from https://www.webofscience.com/
2014
Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations.
González-Galarza, F. F., Takeshita, L. Y. C., Santos, E. J. M., Kempson, F., Maia, M. H. T., Silva, A. L. S. D., . . . Middleton, D. (2014). Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations.. Nucleic Acids Research, 43(D1), D784-D788. doi:10.1093/nar/gku1166
Phenotype Standardization for Statin-Induced Myotoxicity
Alfirevic, A., Neely, D., Armitage, J., Chinoy, H., Cooper, R. G., Laaksonen, R., . . . Pirmohamed, M. (2014). Phenotype Standardization for Statin-Induced Myotoxicity. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(4), 470-476. doi:10.1038/clpt.2014.121
Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System
Wadelius, M., Marshall, S. E., Islander, G., Nordang, L., Karawajczyk, M., Yue, Q. -Y., . . . Palmer, C. N. A. (2014). Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(4), 477-481. doi:10.1038/clpt.2014.138
Pathway Analysis of Genetic Factors Associated with Spontaneous Preterm Birth and Pre-Labor Preterm Rupture of Membranes
Capece, A., Vasieva, O., Meher, S., Alfirevic, Z., & Alfirevic, A. (2014). Pathway Analysis of Genetic Factors Associated with Spontaneous Preterm Birth and Pre-Labor Preterm Rupture of Membranes. PloS One, 9(9). doi:10.1371/journal.pone.0108578
GATM gene variants and statin myopathy risk
Carr, D., Alfirevic, A., Johnson, R., Chinoy, H., van Staa, T., & Pirmohamed, M. (2014). GATM gene variants and statin myopathy risk. Nature, 513(7518). doi:10.1038/nature13628
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles
Goldstein, J. I., Jarskog, L. F., Hilliard, C., Alfirevic, A., Duncan, L., Fourches, D., . . . Sullivan, P. F. (2014). Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. Nature Communications, 5. doi:10.1038/ncomms5757
Abs No: HLA-A*31:01 positive hypersensitive patient
Lichtenfels, M., Farrell, J., Ogese, M., Bell, C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). Abs No: HLA-A*31:01 positive hypersensitive patient. Clinical and translational allergy, 4(Suppl 3), P117. doi:10.1186/2045-7022-4-s3-p117
Characterization of amoxicillin and clavulanic-acid-responsive CD4+ And CD8+ T-cells in patients with co-amoxiclav-induced liver injury
Kim, S. -H., Saide, K., Yuan, Y., Daly, A., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. (2014). Characterization of amoxicillin and clavulanic-acid-responsive CD4+ And CD8+ T-cells in patients with co-amoxiclav-induced liver injury. Clinical and translational allergy, 4(Suppl 3), P42. doi:10.1186/2045-7022-4-s3-p42
Establishment of an HLA-typed cohort of 1000 healthy blood donors and use of a dendritic cell priming assay to prime naive T cells to structurally divergent drugs
Faulkner, L., Wood, S., Van Eker, D., Alfirevic, A., Pirmohamed, M., Naisbitt, D., & Park, K. (2014). Establishment of an HLA-typed cohort of 1000 healthy blood donors and use of a dendritic cell priming assay to prime naive T cells to structurally divergent drugs. Clinical and translational allergy, 4(Suppl 3), P112. doi:10.1186/2045-7022-4-s3-p112
HLA-DQ restricted activation of nitroso-sulfamethoxazole-specific CD4+ T-lymphocytes
Ogese, M., Saide, K., Whitaker, P., Peckham, D., Faulkner, L., Alfirevic, A., . . . Naisbitt, D. (2014). HLA-DQ restricted activation of nitroso-sulfamethoxazole-specific CD4+ T-lymphocytes. Clinical and translational allergy, 4(Suppl 3), P110. doi:10.1186/2045-7022-4-s3-p110
Identification of susceptible HLA class II co-amoxiclav genotypes based on the analysis of drug-specific T-cells from patients with liver injury
Saide, K., Kim, S. -H., Yuan, Y., Daly, A., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. (2014). Identification of susceptible HLA class II co-amoxiclav genotypes based on the analysis of drug-specific T-cells from patients with liver injury. Clinical and translational allergy, 4(Suppl 3), O3. doi:10.1186/2045-7022-4-s3-o3
Skewing of the TCR V repertoire in SMX-NO specific T cell responses
Faulkner, L., Lichtenfels, M., Esser, P., Martin, S., Alfirevic, A., Pirmohamed, M., . . . Park, K. (2014). Skewing of the TCR V repertoire in SMX-NO specific T cell responses. Clinical and translational allergy, 4(Suppl 3), P114. doi:10.1186/2045-7022-4-s3-p114
Is the Interleukin 8 Promoter Polymorphism rs4073/–251T >A Associated With Clostridium difficile Infection?
Miyajima, F., Swale, A., Zhang, E., Alfirevic, A., Little, M., Beeching, N., . . . Pirmohamed, M. (2014). Is the Interleukin 8 Promoter Polymorphism rs4073/–251T >A Associated With Clostridium difficile Infection?. Clinical Infectious Disease, 58(12), e148-e151. doi:10.1093/cid/ciu152
Pharmacogenomics: Current State-of-the-Art
Carr, D. F., Alfirevic, A., & Pirmohamed, M. (2014). Pharmacogenomics: Current State-of-the-Art. GENES, 5(2), 430-443. doi:10.3390/genes5020430
HLA restriction of carbamazepine-specific T-cell clones from an HLA-A*31:01-positive hypersensitive patient
Lichtenfels, M., Farrell, J., Ogese, M. O., Bell, C. C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). HLA restriction of carbamazepine-specific T-cell clones from an HLA-A*31:01-positive hypersensitive patient. Chemical Research in Toxicology, 27(02), 175-177. doi:10.1021/tx400460w
Pharmacogenetics of antiepileptic drug-induced hypersensitivity
Bloch, K. M., Sills, G. J., Pirmohamed, M., & Alfirevic, A. (2014). Pharmacogenetics of antiepileptic drug-induced hypersensitivity. PHARMACOGENOMICS, 15(6), 857-868. doi:10.2217/PGS.14.65
2013
Genetic testing for prevention of severe drug-induced skin rash
Alfirevic, A., Pirmohamed, M., Marinovic, B., Jorgensen, A. L., & Harcourt-Smith, L. (n.d.). Genetic testing for prevention of severe drug-induced skin rash. Cochrane Database of Systematic Reviews. doi:10.1002/14651858.cd010891
Safety pharmacology - Current and emerging concepts
Hamdam, J., Sethu, S., Smith, T., Alfirevic, A., Alhaidari, M., Atkinson, J., . . . Goldring, C. (2013). Safety pharmacology - Current and emerging concepts. TOXICOLOGY AND APPLIED PHARMACOLOGY, 273(2), 229-241. doi:10.1016/j.taap.2013.04.039
COST EFFECTIVENESS OF PHARMACOGENETIC SCREENING PRIOR TO INITIATION OF CARBAMAZEPINE TREATMENT FOR EPILEPSY
Plumpton, C. O., Yip, V., Alfirevic, A., Marson, A., Pirmohamed, M., & Hughes, D. A. (2013). COST EFFECTIVENESS OF PHARMACOGENETIC SCREENING PRIOR TO INITIATION OF CARBAMAZEPINE TREATMENT FOR EPILEPSY. In VALUE IN HEALTH Vol. 16 (pp. A624). doi:10.1016/j.jval.2013.08.1831
A microRNA-based prediction algorithm for diagnosis of non-small lung cell carcinoma in minimal biopsy material
Bediaga, N. G., Davies, M. P. A., Acha-Sagredo, A., Hyde, R., Raji, O. Y., Page, R., . . . Liloglou, T. (2013). A microRNA-based prediction algorithm for diagnosis of non-small lung cell carcinoma in minimal biopsy material. BRITISH JOURNAL OF CANCER, 109(9), 2404-2411. doi:10.1038/bjc.2013.623
PP122—Regulation of human leukocyte antigen expression and nevirapine-induced adverse drug reactions in a malawian hiv-positive population
Cornejo Castro, E. M., Carr, D. F., Marshall, V. A., Chaponda, M., Lane, S., Alfirevic, A., . . . Pirmohamed, M. (2013). PP122—Regulation of human leukocyte antigen expression and nevirapine-induced adverse drug reactions in a malawian hiv-positive population. Clinical Therapeutics, 35(8), e53. doi:10.1016/j.clinthera.2013.07.145
PP126—In-vitro reactivity of drug-specific t-cells from a HLA-A*31:01 positive carbamazepine hypersensitive patient
Lichtenfels, M., Naisbitt, D. J., Alfirevic, A., Park, K. B., & Pirmohamed, M. (2013). PP126—In-vitro reactivity of drug-specific t-cells from a HLA-A*31:01 positive carbamazepine hypersensitive patient. Clinical Therapeutics, 35(8), e54. doi:10.1016/j.clinthera.2013.07.148
ABCB1 single nucleotide polymorphisms (1236C > T, 2677G > T, and 3435C > T) do not affect transport activity of human P-glycoprotein
Dickens, D., Owen, A., Alfirevic, A., & Pirmohamed, M. (2013). ABCB1 single nucleotide polymorphisms (1236C > T, 2677G > T, and 3435C > T) do not affect transport activity of human P-glycoprotein. PHARMACOGENETICS AND GENOMICS, 23(6), 314-323. doi:10.1097/FPC.0b013e328360d10c
A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp
Dickens, D., Yusof, S. R., Abbott, N. J., Weksler, B., Romero, I. A., Couraud, P. -O., . . . Owen, A. (2013). A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp. PLOS ONE, 8(5). doi:10.1371/journal.pone.0064854
T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms
Bell, C. C., Faulkner, L., Martinsson, K., Farrell, J., Alfirevic, A., Tugwood, J., . . . Park, B. K. (2013). T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms. CHEMICAL RESEARCH IN TOXICOLOGY, 26(5), 759-766. doi:10.1021/tx400060p
Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population
Carr, D. F., Chaponda, M., Jorgensen, A. L., Castro, E. C., van Oosterhout, J. J., Khoo, S. H., . . . Pirmohamed, M. (2013). Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population. CLINICAL INFECTIOUS DISEASES, 56(9), 1330-1339. doi:10.1093/cid/cit021
Response to "HLA Allelic Variants and Carbamazepine-Induced Hypersensitivity"
Yip, V. L. M., Pirmohamed, M., & Alfirevic, A. (2013). Response to "HLA Allelic Variants and Carbamazepine-Induced Hypersensitivity". CLINICAL PHARMACOLOGY & THERAPEUTICS, 93(5), 387. doi:10.1038/clpt.2013.5
Response to "HLA allelic variants and carbamazepine-induced hypersensitivity".
Yip, V., Pirmohamed, M., & Alfirevic, A. (2013). Response to "HLA allelic variants and carbamazepine-induced hypersensitivity".. Clinical Pharmacology and Therapeutics, 93(5), 387.
Human Leukocyte Antigen (HLA)-B<SUP>☆</SUP>57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury
Monshi, M. M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2013). Human Leukocyte Antigen (HLA)-B<SUP>☆</SUP>57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury. HEPATOLOGY, 57(2), 727-739. doi:10.1002/hep.26077
A multi-system approach assessing the interaction of anticonvulsants with P-gp.
Dickens, D., Yusof, S. R., Abbott, N. J., Weksler, B., Romero, I. A., Couraud, P. -O., . . . Owen, A. (2013). A multi-system approach assessing the interaction of anticonvulsants with P-gp.. PloS One, 8(5), e64854.
Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives
Farrell, J., Lichtenfels, M., Sullivan, A., Elliott, E. C., Alfirevic, A., Stachulski, A. V., . . . Park, B. K. (2013). Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132(2), 493-495. doi:10.1016/j.jaci.2013.02.045
The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK
Alfirevic, A., Carr, D. F., Miyajima, F., Pushpakom, S., Sutton, L., Jorgensen, A. L., & Pirmohamed, M. (2013). The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK. PHARMACOGENOMICS, 14(8), 861-867. doi:10.2217/PGS.13.73
2012
HLA Genotype and Carbamazepine-Induced Cutaneous Adverse Drug Reactions: A Systematic Review
Yip, V. L., Marson, A. G., Jorgensen, A. L., Pirmohamed, M., & Alfirevic, A. (2012). HLA Genotype and Carbamazepine-Induced Cutaneous Adverse Drug Reactions: A Systematic Review. CLINICAL PHARMACOLOGY & THERAPEUTICS, 92(6), 757-765. doi:10.1038/clpt.2012.189
HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review.
Yip, V., Marson, T., Jorgensen, A., Pirmohamed, M., & Alfirevic, A. (2012). HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review.. Clinical Pharmacology and Therapeutics, 92(6), 757-765.
Explanation for <i>HLA</i>-<i>B</i>*<i>57</i>:<i>01</i>-linked immune-mediated abacavir-induced hypersensitivity
Alfirevic, A., Park, B. K., Pirmohamed, M., & Naisbitt, D. J. (2012). Explanation for <i>HLA</i>-<i>B</i>*<i>57</i>:<i>01</i>-linked immune-mediated abacavir-induced hypersensitivity. PHARMACOGENOMICS, 13(14), 1567-1569. doi:10.2217/PGS.12.146
Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical Utility
Alfirevic, A., & Pirmohamed, M. (2012). Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical Utility. CLINICAL PHARMACOLOGY & THERAPEUTICS, 92(3), 376-380. doi:10.1038/clpt.2012.107
<i>In silico</i> analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers
Alfirevic, A., Gonzalez-Galarza, F., Bell, C., Martinsson, K., Platt, V., Bretland, G., . . . Pirmohamed, M. (2012). <i>In silico</i> analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers. GENOME MEDICINE, 4. doi:10.1186/gm350
5th Anniversary meeting of the European Research Network Pharmacogenetics/Pharmacogenomics. 8-9 December 2011, Utrecht, The Netherlands.
Fox, J. C., Daly, A., Cascorbi, I., Alfirevic, A., Linden, H., & Maitland-van der Zee, A. -H. (2012). 5th Anniversary meeting of the European Research Network Pharmacogenetics/Pharmacogenomics. 8-9 December 2011, Utrecht, The Netherlands.. Pharmacogenomics, 13(7), 747-749. doi:10.2217/pgs.12.43
MicroRNAs for early detection of lung cancer
Bediaga, N., Davies, M. P. A., Raji, O. Y., Alfirevic, A., Liloglou, T., & Field, J. K. (2012). MicroRNAs for early detection of lung cancer. CANCER RESEARCH, 72. doi:10.1158/1538-7445.AM2012-4133
Lamotrigine is a substrate for OCT1 in brain endothelial cells
Dickens, D., Owen, A., Alfirevic, A., Giannoudis, A., Davies, A., Weksler, B., . . . Pirmohamed, M. (2012). Lamotrigine is a substrate for OCT1 in brain endothelial cells. BIOCHEMICAL PHARMACOLOGY, 83(6), 805-814. doi:10.1016/j.bcp.2011.12.032
5th Anniversary meeting of the European Research Network Pharmacogenetics/Pharmacogenomics. 8-9 December 2011, Utrecht, The Netherlands
Fox, J. C., Daly, A., Cascorbi, I., Alfirevic, A., Linden, H., & Maitland-van der Zee, A. H. (2012). 5th Anniversary meeting of the European Research Network Pharmacogenetics/Pharmacogenomics. 8-9 December 2011, Utrecht, The Netherlands. Pharmacogenomics, 13(7), 747-749.
HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury
Monshi, M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2012). HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury. Hepatology.
Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal
Alfirevic, A., McCormack, M., Pirmohamed, M., & Cavalleri, G. L. (2012). Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal. BRITISH JOURNAL OF DERMATOLOGY, 166(1), 12-14. doi:10.1111/j.1365-2133.2011.10760.x
Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal.
Alfirevic, A., McCormack, M., Pirmohamed, M., & Cavalleri, G. L. (2012). Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal.. British Journal of Dermatology, 166(1), 12-14.
2011
Pharmacogenomics and personalized medicine: the plunge into next-generation sequencing.
Wadelius, M., & Alfirevic, A. (2011). Pharmacogenomics and personalized medicine: the plunge into next-generation sequencing.. Genome medicine, 3(12), 78. doi:10.1186/gm294
Establishment of an HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions
Bell, C., Martinsson, K., Faulkner, L., Alfirevic, A., French, N., Tugwood, J., . . . Park, B. K. (2011). Establishment of an HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions. TOXICOLOGY, 290(2-3), 132-133. doi:10.1016/j.tox.2011.09.057
HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans
McCormack, M., Alfirevic, A., Bourgeois, S., Farrell, J. J., Kasperaviciute, D., Carrington, M., . . . Pirmohamed, M. (2011). HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans. NEW ENGLAND JOURNAL OF MEDICINE, 364(12), 1134-1143. doi:10.1056/NEJMoa1013297
Report on the 8th Annual Cold Spring Harbor/Wellcome Trust meeting on Pharmacogenomics and Personalized Medicine.
Carr, D. F., & Alfirevic, A. (2011). Report on the 8th Annual Cold Spring Harbor/Wellcome Trust meeting on Pharmacogenomics and Personalized Medicine.. Pharmacogenomics, 12(3), 315-317. doi:10.2217/pgs.10.217
Drug Induced Hypersensitivity and the HLA Complex
Drug Induced Hypersensitivity and the HLA Complex (2010). Pharmaceuticals (Basel, Switzerland), 4(1), 69-90.
HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans
McCormack, M., Alfirevic, A., Bourgeois, S., Farrell, J. J., Kasperavičiūtė, D., Carrington, M., . . . Pirmohamed, M. (2011). HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med, 364(12), 1134-1143.
Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors
Mirza, N. S., Alfirevic, A., Jorgensen, A., Marson, A. G., & Pirmohamed, M. (2011). Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors. PHARMACOGENETICS AND GENOMICS, 21(5), 297-302. doi:10.1097/FPC.0b013e3283441b95
Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics.
Becquemont, L., Alfirevic, A., Amstutz, U., Brauch, H., Jacqz-Aigrain, E., Laurent-Puig, P., . . . Daly, A. K. (2011). Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics.. Pharmacogenomics, 12(1), 113-124. doi:10.2217/pgs.10.147
2010
Pharmacogenetics and pharmacogenomics: practical applications in routine medical practice.
Maitland-van der Zee, A. -H., & Alfirevic, A. (2010). Pharmacogenetics and pharmacogenomics: practical applications in routine medical practice.. Genome medicine, 2(9), 69. doi:10.1186/gm190
Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future
Alfirevic, A., & Pirmohamed, M. (2010). Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future. PHARMACOGENOMICS, 11(4), 497-499. doi:10.2217/PGS.10.12
Deletion of exon 3 in the growth hormone receptor gene in adults with growth hormone deficiency: comparison of symptomatic and asymptomatic patients
Adetunji, O. R., Blair, J. C., Javadpour, M., Alfirevic, A., Pirmohamed, M., & MacFarlane, I. A. (2010). Deletion of exon 3 in the growth hormone receptor gene in adults with growth hormone deficiency: comparison of symptomatic and asymptomatic patients. CLINICAL ENDOCRINOLOGY, 72(3), 422-423. doi:10.1111/j.1365-2265.2009.03638.x
Randomized Controlled Trial: Lisinopril Reduces Proteinuria, Ammonia, and Renal Polypeptide Tubular Catabolism in Patients With Chronic Allograft Nephropathy
Amara, A. B., Sharma, A., Alexander, J. L., Alfirevic, A., Mohiuddin, A., Pirmohamed, M., . . . Rustom, R. (2010). Randomized Controlled Trial: Lisinopril Reduces Proteinuria, Ammonia, and Renal Polypeptide Tubular Catabolism in Patients With Chronic Allograft Nephropathy. TRANSPLANTATION, 89(1), 104-114. doi:10.1097/TP.0b013e3181bf13d9
Pharmacogenetics in reproductive and perinatal medicine
Alfirevic, A., Alfirevic, Z., & Pirmohamed, M. (2010). Pharmacogenetics in reproductive and perinatal medicine. PHARMACOGENOMICS, 11(1), 65-79. doi:10.2217/PGS.09.153
Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future.
Alfirevic, A., & Pirmohamed, M. (2010). Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future.. Pharmacogenomics, 11(4), 497-499.
Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.
Mirza, N. S., Alfirevic, A., Jorgensen, A., Marson, A. G., & Pirmohamed, M. (2010). Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.. Pharmacogenetics and Genomics, 21(5), 297-302.
Pharmacogenetics in reproductive and perinatal medicine
Alfirevic, A., Alfirevic, Z., & Pirmohamed, M. (2010). Pharmacogenetics in reproductive and perinatal medicine. Pharmacogenomics, 11(1), 65-79.
2009
The d3/fl-GH receptor gene polymorphism does not influence quality of life and body composition in GH-deficient adults receiving GH replacement therapy
Adetunji, O. R., MacFarlane, I. A., Javadpour, M., Alfirevic, A., Pirmohamed, M., & Blair, J. C. (2009). The d3/fl-GH receptor gene polymorphism does not influence quality of life and body composition in GH-deficient adults receiving GH replacement therapy. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 161(4), 541-546. doi:10.1530/EJE-09-0405
Effects of <i>CYP4F2</i> genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy
Zhang, J. E., Jorgensen, A. L., Alfirevic, A., Williamson, P. R., Toh, C. H., Park, B. K., & Pirmohamed, M. (2009). Effects of <i>CYP4F2</i> genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy. PHARMACOGENETICS AND GENOMICS, 19(10), 781-789. doi:10.1097/FPC.0b013e3283311347
Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review
Carr, D. F., Whiteley, G., Alfirevic, A., & Pirmohamed, M. (2009). Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review. PHARMACOGENOMICS JOURNAL, 9(5), 291-305. doi:10.1038/tpj.2009.29
<i>TNF</i>, <i>LTA</i>, <i>HSPA1L</i> and <i>HLA</i>-<i>DR</i> gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole
Alfirevic, A., Vilar, F. J., Alsbou, M., Jawaid, A., Thomson, W., Ollier, W. E. R., . . . Pirmohamed, M. (2009). <i>TNF</i>, <i>LTA</i>, <i>HSPA1L</i> and <i>HLA</i>-<i>DR</i> gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole. PHARMACOGENOMICS, 10(4), 531-540. doi:10.2217/PGS.09.6
Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy
Zhang, J. E., Jorgensen, A. L., Alfirevic, A., Williamson, P. R., Toh, C. H., Park, B. K., & Pirmohamed, M. (2009). Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy. Pharmacogenetics and Genomics, 10, 781-789.
2008
Pharmacogenetics of adverse drug reactions: A pharmacovigilance perspective
Alfirevic, A., & Pirmohamed, M. (2008). Pharmacogenetics of adverse drug reactions: A pharmacovigilance perspective. Journal of Applied Therapeutic Research, 6(3), 3-8.
Pharmacogenetics and pharmacogenomics: adverse drug reactions.
Jorgensen, A., & Alfirevic, A. (2008). Pharmacogenetics and pharmacogenomics: adverse drug reactions.. Pharmacogenomics, 9(10), 1397-1401. doi:10.2217/14622416.9.10.1397
Adverse drug reactions and pharmacogenomics: recent advances
Alfirevic, A., & Pirmohamed, M. (2008). Adverse drug reactions and pharmacogenomics: recent advances. PERSONALIZED MEDICINE, 5(1), 11-23. doi:10.2217/17410541.5.1.11
2007
Tacrine-induced liver damage: an analysis of 19 candidate genes
Alfirevic, A., Mills, T., Carr, D., Barratt, B. J., Jawaid, A., Sherwood, J., . . . Pirmohamed, M. (2007). Tacrine-induced liver damage: an analysis of 19 candidate genes. PHARMACOGENETICS AND GENOMICS, 17(12), 1091-1100. doi:10.1097/FPC.0b013e3282f1f12b
Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity
Carr, D. F., Alfirevic, A., Tugwood, J. D., Barratt, B. J., Sherwood, J., Smith, J., . . . Park, B. K. (2007). Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity. PHARMACOGENETICS AND GENOMICS, 17(11), 961-972. doi:10.1097/FPC.0b013e3282f00919
Pharmacogenetics of adverse drug reactions: a pharmacovigilance perspective.
Alfirevic, A., & Pirmohamed, M. (2007). Pharmacogenetics of adverse drug reactions: a pharmacovigilance perspective.. Pharmacovigilance Review, 1(3), 22-25.
2006
<i>HLA-B</i> locus in Caucasian patients with carbamazepine hypersensitivity
Alfirevic, A., Jorgensen, A. L., Williamson, P. R., Chadwick, D. W., Park, B. K., & Pirmohamed, M. (2006). <i>HLA-B</i> locus in Caucasian patients with carbamazepine hypersensitivity. PHARMACOGENOMICS, 7(6), 813-818. doi:10.2217/14622416.7.6.813
The 2nd International Drug Hypersensitivity Meeting
Alfirevic, A., & Naisbitt, D. J. (2006). The 2nd International Drug Hypersensitivity Meeting. Expert Opinion on Drug Safety, 5(5), 729-734. doi:10.1517/14740338.5.5.729
Pharmacogenetics of Adverse Drug Reactions
Alfirevic, A., & Park, B. (2006). Pharmacogenetics of Adverse Drug Reactions. In Pharmacogenetics (pp. 65-89). CRC Press. doi:10.3109/9781420016697-6
Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster
Alfirevic, A., Mills, T., Harrington, P., Pinel, T., Sherwood, J., Jawaid, A., . . . Pirmohamed, M. (2006). Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. PHARMACOGENETICS AND GENOMICS, 16(4), 287-296. doi:10.1097/01.fpc.0000189800.88596.7a
Pharmacogenetics of Adverse Drug Reactions
Alfirevic, A., Park, B. K., & Pirmohamed, M. (2006). Pharmacogenetics of Adverse Drug Reactions. In I. Hall, & M. Pirmohamed (Eds.), Textbook of Pharmacogenetics (pp. in press). New York: Marcel Dekker.
2005
Association between serious carbamazepine hypersensitivity reactions and the HSP70 gene cluster
Alfirevic, A., Mills, T., Harrington, P., Pinel, T., Sherwood, J., Jawaid, A., . . . Pirmohamed, M. (2005). Association between serious carbamazepine hypersensitivity reactions and the HSP70 gene cluster. TOXICOLOGY, 213(3), 264-265. Retrieved from https://www.webofscience.com/
Molecular aspects of carbamazepine-induced hypersensitivity reactions
Alfirevic, A. (2005). Molecular aspects of carbamazepine-induced hypersensitivity reactions. (PhD Thesis, The University of Liverpool).
2004
Cost-effectiveness analysis of HLA <i>B</i>*<i>5701</i> genotyping in preventing abacavir hypersensitivity
Hughes, D. A., Vilar, F. J., Ward, C. C., Alfirevic, A., Park, B. K., & Pirmohamed, M. (2004). Cost-effectiveness analysis of HLA <i>B</i>*<i>5701</i> genotyping in preventing abacavir hypersensitivity. PHARMACOGENETICS, 14(6), 335-342. doi:10.1097/00008571-200406000-00002
Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity.
Hughes, D. A., Vilar, F. J., Ward, C. C., Alfirevic, A., Park, B. K., & Pirmohamed, M. (2004). Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity.. Pharmacogenetics, 14(6), 335-342. doi:10.1097/00008571-200406000-00002
2003
Erratum
Erratum (2003). British Journal of Clinical Pharmacology, 55(4), 417. doi:10.1046/j.1365-2125.2003.01815.x
Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity
Alfirevic, A., Stalford, A. C., Vilar, F. J., Wilkins, E. G. L., Park, B. K., & Pirmohamed, M. (2003). Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 55(2), 158-165. doi:10.1046/j.1365-2125.2003.01754.x
2002
TNF-α promoter region gene polymorphisms in HIV-positive patients with lipodystrophy
Maher, B., Alfirevic, A., Vilar, F. J., Wilkins, E. G. L., Park, B. K., & Pirmohamed, M. (2002). TNF-α promoter region gene polymorphisms in HIV-positive patients with lipodystrophy. AIDS, 16(15), 2013-2018. doi:10.1097/00002030-200210180-00005
2001
TNF-α promoter region gene polymorphisms in patients with alcohol-induced chronic pancreatitis
Ahdulrazeg, E. S. M., Alfirevic, A., Gilmore, I. T., Sutton, R., Greenhalf, W., Neoptolemas, J., . . . Pirmohamed, M. (2001). TNF-α promoter region gene polymorphisms in patients with alcohol-induced chronic pancreatitis. In GASTROENTEROLOGY Vol. 120 (pp. A32-A33). Retrieved from https://www.webofscience.com/
TNF-α promoter region gene polymorphisms in patients with alcohol-induced chronic pancreatitis
Abdulrazeg, E. -S. M., Alfirevic, A., Gilmore, I. T., Sutton, R., Greenhalf, W., Neoptolemos, J., . . . Pirmohamed, M. (2001). TNF-α promoter region gene polymorphisms in patients with alcohol-induced chronic pancreatitis. Gastroenterology, 120(5), A32-A33. doi:10.1016/s0016-5085(08)80159-x
2000
Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity
Pirmohamed, M., Alfirevic, A., Vilar, J., Stalford, A., Wilkins, E. G. L., Sim, E., & Park, B. K. (2000). Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity. PHARMACOGENETICS, 10(8), 705-713. doi:10.1097/00008571-200011000-00005
1989
Correlation between bone scans and serum levels of osteocalcin, prostate-specific antigen, and prostatic acid phosphatase in monitoring patients with disseminated cancer of the prostate.
Tarle, M., Kovaćić, K., & Strelkov-Alfirević, A. (1989). Correlation between bone scans and serum levels of osteocalcin, prostate-specific antigen, and prostatic acid phosphatase in monitoring patients with disseminated cancer of the prostate.. The Prostate, 15(3), 211-219. doi:10.1002/pros.2990150302