Publications
2024
Near millimolar concentration of nucleosomes in mitotic chromosomes from late prometaphase into anaphase.
Cisneros-Soberanis, F., Simpson, E. L., Beckett, A. J., Pucekova, N., Corless, S., Kochanova, N. Y., . . . Earnshaw, W. C. (2024). Near millimolar concentration of nucleosomes in mitotic chromosomes from late prometaphase into anaphase.. The Journal of cell biology, 223(11), e202403165. doi:10.1083/jcb.202403165
Rules of engagement for condensins and cohesins guide mitotic chromosome formation.
2022
Optical photothermal infrared spectroscopy can differentiate equine osteoarthritic plasma extracellular vesicles from healthy controls
Clarke, E. J., Lima, C., Anderson, J. R., Castanheira, C., Beckett, A., James, V., . . . Peffers, M. J. (2022). Optical photothermal infrared spectroscopy can differentiate equine osteoarthritic plasma extracellular vesicles from healthy controls. ANALYTICAL METHODS. doi:10.1039/d2ay00779g
Novel roles of RTN4 and CLIMP-63 in regulating mitochondrial structure, bioenergetics and apoptosis
Carter, R. J., Milani, M., Beckett, A. J., Liu, S., Prior, I. A., Cohen, G. M., & Varadarajan, S. (2022). Novel roles of RTN4 and CLIMP-63 in regulating mitochondrial structure, bioenergetics and apoptosis. CELL DEATH & DISEASE, 13(5). doi:10.1038/s41419-022-04869-8
Effect of Local Topography on Cell Division of <i>Staphylococcus</i> spp.
Sorzabal-Bellido, I., Barbieri, L., Beckett, A. J., Prior, I. A., Susarrey-Arce, A., Tiggelaar, R. M., . . . Fernandez, Y. A. D. (2022). Effect of Local Topography on Cell Division of <i>Staphylococcus</i> spp.. NANOMATERIALS, 12(4). doi:10.3390/nano12040683
2021
Imaging of Nanoscale Gold in “Intact” Biological Cells by Environmental Electron Microscopy
Belić, D., Fragueiro, O., Salah, D., Beckett, A., Volk, M., & Brust, M. (2021). Imaging of Nanoscale Gold in “Intact” Biological Cells by Environmental Electron Microscopy. The Journal of Physical Chemistry C. doi:10.1021/acs.jpcc.1c09104
One-step preparation of antimicrobial silicone materials based on PDMS and salicylic acid: insights from spatially and temporally resolved techniques
Barbieri, L., Sorzabal Bellido, I., Beckett, A. J., Prior, I. A., Fothergill, J., Diaz Fernandez, Y. A., & Raval, R. (2021). One-step preparation of antimicrobial silicone materials based on PDMS and salicylic acid: insights from spatially and temporally resolved techniques. NPJ BIOFILMS AND MICROBIOMES, 7(1). doi:10.1038/s41522-021-00223-6
Isolation and characterisation of bacteriophages with activity against invasive non-typhoidal Salmonella causing bloodstream infection in Malawi
Rodwell, E., Wenner, N., Pulford, C., Cai, Y., Bowers-Barnard, A., Beckett, A., . . . Perez Sepulveda, B. (n.d.). Isolation and characterisation of bacteriophages with activity against invasive non-typhoidal Salmonella causing bloodstream infection in Malawi. Viruses. doi:10.3390/v13030478
2020
Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle
Badgujar, D. C., Anil, A., Green, A. E., Surve, M. V., Madhavan, S., Beckett, A., . . . Banerjee, A. (2020). Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle. PLOS PATHOGENS, 16(11). doi:10.1371/journal.ppat.1009016
Exploring High Aspect Ratio Gold Nanotubes as Cytosolic Agents: Structural Engineering and Uptake into Mesothelioma Cells
Ye, S., Azad, A. A., Chambers, J. E., Beckett, A. J., Roach, L., Moorcroft, S. C. T., . . . Evans, S. D. (2020). Exploring High Aspect Ratio Gold Nanotubes as Cytosolic Agents: Structural Engineering and Uptake into Mesothelioma Cells. Small, 2003793. doi:10.1002/smll.202003793
The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine.
Jolly, C. E., Douglas, O., Kamalian, L., Jenkins, R. E., Beckett, A. J., Penman, S. L., . . . Chadwick, A. E. (2020). The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine.. Toxicology and applied pharmacology, 403, 115163. doi:10.1016/j.taap.2020.115163
LAP-like non-canonical autophagy and evolution of endocytic vacuoles in pancreatic acinar cells
De Faveri, F., Chvanov, M., Voronina, S., Moore, D., Pollock, L., Haynes, L., . . . Tepikin, A. (2020). LAP-like non-canonical autophagy and evolution of endocytic vacuoles in pancreatic acinar cells. Autophagy, 16(7), 1314-1331. doi:10.1080/15548627.2019.1679514
Trypanosoma brucei colonizes the tsetse gut via an immature peritrophic matrix in the proventriculus
Rose, C., Casas-Sanchez, A., Dyer, N. A., Solorzano, C., Beckett, A. J., Middlehurst, B., . . . Acosta-Serrano, A. (2020). Trypanosoma brucei colonizes the tsetse gut via an immature peritrophic matrix in the proventriculus. Nature Microbiology, 5(7), 909-916. doi:10.1038/s41564-020-0707-z
Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle
Badgujar, D., Anil, A., Green, A., Surve, M. V., Madhavan, S., Beckett, A., . . . Banerjee, A. (2020). Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle. doi:10.1101/2020.05.13.093682
2019
Exploiting Covalent, H-Bonding, and π–π Interactions to Design Antibacterial PDMS Interfaces That Load and Release Salicylic Acid
Sorzabal Bellido, I., Diaz Fernandez, Y. A., Skelton, A. A., Susarrey Arce, A., McBride, F., Prior, I. A., . . . Raval, R. (2019). Exploiting Covalent, H-Bonding, and π–π Interactions to Design Antibacterial PDMS Interfaces That Load and Release Salicylic Acid. ACS Appl. Bio Mater.. doi:10.1021/acsabm.9b00562
Concentric lamellae - novel microanatomical structures in the articular calcified cartilage of mice
Keenan, C. M., Beckett, A. J., Sutherland, H., Ranganath, L. R., Jarvis, J. C., Prior, I. A., & Gallagher, J. A. (2019). Concentric lamellae - novel microanatomical structures in the articular calcified cartilage of mice. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-47545-2
DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis.
Milani, M., Beckett, A. J., Al-Zebeeby, A., Luo, X., Prior, I. A., Cohen, G. M., & Varadarajan, S. (2019). DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis.. Cell death discovery, 5, 117. doi:10.1038/s41420-019-0199-x
SuperCLEM: an accessible correlative light and electron microscopy approach for investigation of neurons and glia in vitro.
Booth, D. G., Beckett, A. J., Prior, I. A., & Meijer, D. (2019). SuperCLEM: an accessible correlative light and electron microscopy approach for investigation of neurons and glia in vitro.. Biology open. doi:10.1242/bio.042085
<i>Trypanosoma brucei</i>colonises the tsetse gut via an immature peritrophic matrix in the proventriculus
Rose, C., Dyer, N., Casas-Sanchez, A., Beckett, A., Solórzano, C., Middlehurst, B., . . . Acosta-Serrano, Á. (2019). <i>Trypanosoma brucei</i>colonises the tsetse gut via an immature peritrophic matrix in the proventriculus. doi:10.1101/513689
2017
Modular approach for bimodal antibacterial surfaces combining photo-switchable activity and sustained biocidal release
Pallavicini, P., Bassi, B., Chirico, G., Collini, M., Dacarro, G., Fratini, E., . . . Diaz Fernandez, Y. A. (2017). Modular approach for bimodal antibacterial surfaces combining photo-switchable activity and sustained biocidal release. Scientific Reports, 7. doi:10.1038/s41598-017-05693-3
Serial block-face scanning electron microscopy applied to study the trafficking of 8D3-coated gold nanoparticles at the blood-brain barrier
Cabezón, I., Augé, E., Bosch, M., Beckett, A. J., Prior, I. A., Pelegrí, C., & Vilaplana, J. (2017). Serial block-face scanning electron microscopy applied to study the trafficking of 8D3-coated gold nanoparticles at the blood-brain barrier. Histochemistry and cell biology, 148(01), 3-12. doi:10.1007/s00418-017-1553-9
Microtubule organization within mitotic spindles revealed by serial block face scanning electron microscopy and image analysis
Nixon, F. M., Honnor, T. R., Clarke, N. I., Starling, G. P., Beckett, A. J., Johansen, A. M., . . . Royle, S. J. (2017). Microtubule organization within mitotic spindles revealed by serial block face scanning electron microscopy and image analysis. Journal of Cell Science, 130(10), 1845-1855. doi:10.1242/jcs.203877
2016
The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z‐α1‐antitrypsin
Dickens, J. A., Ordóñez, A., Chambers, J. E., Beckett, A. J., Patel, V., Malzer, E., . . . Marciniak, S. J. (2016). The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z‐α1‐antitrypsin. The FASEB Journal, 30(12), 4083-4097. doi:10.1096/fj.201600430R
3D-CLEM Reveals that a Major Portion of Mitotic Chromosomes Is Not Chromatin
Booth, D. G., Beckett, A. J., Molina, O., Samejima, I., Masumoto, H., Kouprina, N., . . . Earnshaw, W. C. (2016). 3D-CLEM Reveals that a Major Portion of Mitotic Chromosomes Is Not Chromatin. Molecular cell, 64(4), 790-802. doi:10.1016/j.molcel.2016.10.009
Microtubule organization within mitotic spindles revealed by serial block face scanning EM and image analysis
Bacterial viability on chemically modified silicon nanowire arrays
Susarrey-Arce, A., Sorzabal-Bellido, I., Oknianska, A., McBride, F., Beckett, A. J., Gardeniers, J. G. E., . . . Fernandez, Y. A. D. (2016). Bacterial viability on chemically modified silicon nanowire arrays. JOURNAL OF MATERIALS CHEMISTRY B, 4(18), 3104-3112. doi:10.1039/c6tb00460a
Highly Stable and Conductive Microcapsules for Enhancement of Joule Heating Performance
Zheng, Z., Jin, J., Xu, G. K., Zou, J., Wais, U., Beckett, A., . . . Shchukin, D. (2016). Highly Stable and Conductive Microcapsules for Enhancement of Joule Heating Performance. ACS Nano, 10(4), 4695-4703. doi:10.1021/acsnano.6b01104
2015
The role of Ca2+influx in endocytic vacuole formation in pancreatic acinar cells
Voronina, S., Collier, D., Chvanov, M., Middlehurst, B., Beckett, A., Prior, I., . . . Tepikin, A. V. (2015). The role of Ca2+influx in endocytic vacuole formation in pancreatic acinar cells. Biochemical Journal, 465(3), 405-412. doi:10.1042/BJ20140398
Electron Microscopy Methods for Studying Plasma Membranes
Beckett, A. J., & Prior, I. A. (2015). Electron Microscopy Methods for Studying Plasma Membranes. METHODS IN MEMBRANE LIPIDS, SECOND EDITION, 1232, 137-151. doi:10.1007/978-1-4939-1752-5_12
2014
Correction: Transport of Fibroblast Growth Factor 2 in the Pericellular Matrix Is Controlled by the Spatial Distribution of Its Binding Sites in Heparan Sulfate
Correction: Transport of Fibroblast Growth Factor 2 in the Pericellular Matrix Is Controlled by the Spatial Distribution of Its Binding Sites in Heparan Sulfate (n.d.). PLoS Biology, 12(9), e1001976. doi:10.1371/journal.pbio.1001976
Plasticity of Mammary Cell Boundaries Governed by EGF and Actin Remodeling
Tang, W. Y., Beckett, A., Prior, I., Coulson, J., Urbe, S., & Clague, M. (2014). Plasticity of Mammary Cell Boundaries Governed by EGF and Actin Remodeling. Cell Reports, 8(06), 1722-1730. doi:10.1016/j.celrep.2014.08.026
IDENTIFICATION OF CONCENTRIC LAMELLAE IN THE ARTICULAR CALCIFIED CARTILAGE OF OSTEOARTHRITIC MICE
Keenan, C. M., Beckett, A., Sutherland, H., Prior, I., Ranganath, L. R., Jarvis, J. C., & Gallagher, J. A. (2014). IDENTIFICATION OF CONCENTRIC LAMELLAE IN THE ARTICULAR CALCIFIED CARTILAGE OF OSTEOARTHRITIC MICE. In OSTEOARTHRITIS AND CARTILAGE Vol. 22 (pp. S363-S364). doi:10.1016/j.joca.2014.02.673
2013
Oncogenic K-ras segregates at spatially distinct plasma membrane signaling platforms according to its phosphorylation status
Barcelo, C., Paco, N., Beckett, A. J., Alvarez-Moya, B., Garrido, E., Gelabert, M., . . . Agell, N. (2013). Oncogenic K-ras segregates at spatially distinct plasma membrane signaling platforms according to its phosphorylation status. JOURNAL OF CELL SCIENCE, 126(20), 4553-4559. doi:10.1242/jcs.123737
The role of palmitoylation in regulating Ras localization and function
Eisenberg, S., Laude, A. J., Beckett, A. J., Mageean, C. J., Aran, V., Hernandez-Valladares, M., . . . Prior, I. A. (2013). The role of palmitoylation in regulating Ras localization and function. BIOCHEMICAL SOCIETY TRANSACTIONS, 41, 79-83. doi:10.1042/BST20120268
Plasticity of mammary cell boundaries governed by EGF
Tang, Y., Beckett, A. J., Prior, I. A., Coulson, J. M., Urbe, S., & Clague, M. J. (2013). Plasticity of mammary cell boundaries governed by EGF. MOLECULAR BIOLOGY OF THE CELL, 24. Retrieved from https://www.webofscience.com/
2012
Transport of Fibroblast Growth Factor 2 in the Pericellular Matrix Is Controlled by the Spatial Distribution of Its Binding Sites in Heparan Sulfate
Duchesne, L., Octeau, V., Bearon, R. N., Beckett, A., Prior, I. A., Lounis, B., & Fernig, D. G. (2012). Transport of Fibroblast Growth Factor 2 in the Pericellular Matrix Is Controlled by the Spatial Distribution of Its Binding Sites in Heparan Sulfate. PLOS BIOLOGY, 10(7). doi:10.1371/journal.pbio.1001361
2011
Raft Protein Clustering Alters N-Ras Membrane Interactions and Activation Pattern
Eisenberg, S., Beckett, A. J., Prior, I. A., Dekker, F. J., Hedberg, C., Waldmann, H., . . . Henis, Y. I. (2011). Raft Protein Clustering Alters N-Ras Membrane Interactions and Activation Pattern. MOLECULAR AND CELLULAR BIOLOGY, 31(19), 3938-3952. doi:10.1128/MCB.05570-11
Oceanic sharks clean at coastal seamount.
Oliver, S. P., Hussey, N. E., Turner, J. R., & Beckett, A. J. (2011). Oceanic sharks clean at coastal seamount.. PloS one, 6(3), e14755. doi:10.1371/journal.pone.0014755
2010
Highly Stable Dextran-Coated Quantum Dots for Biomolecular Detection and Cellular Imaging
Wilson, R., Spiller, D. G., Beckett, A., Prior, I. A., & See, V. (2010). Highly Stable Dextran-Coated Quantum Dots for Biomolecular Detection and Cellular Imaging. CHEMISTRY OF MATERIALS, 22(23), 6361-6369. doi:10.1021/cm1023635
2009
A reliable method for attaching biological molecules to layer-by-layer self-assemblies
Wilson, R., Mehrabi, M., Prior, I. A., Beckett, A., & Hutchinson, A. (2009). A reliable method for attaching biological molecules to layer-by-layer self-assemblies. CHEMICAL COMMUNICATIONS, (18), 2487-2489. doi:10.1039/b822688a