Publications
2024
Simulation to optimize the laboratory diagnosis of bacteremia.
Gerada, A., Roberts, G., Howard, A., Reza, N., Velluva, A., Rosato, C., . . . Hope, W. (2024). Simulation to optimize the laboratory diagnosis of bacteremia.. Microbiology spectrum, e0144924. doi:10.1128/spectrum.01449-24
AIgarMIC: a Python package for automated interpretation of agar dilution minimum inhibitory concentration assays
Gerada, A., Harper, N., Howard, A., & Hope, W. (2024). AIgarMIC: a Python package for automated interpretationof agar dilution minimum inhibitory concentration assays. Journal of Open Source Software, 9(101), 6826. doi:10.21105/joss.06826
Bayesian estimation of the prevalence of antimicrobial resistance: a mathematical modelling study.
Howard, A., Green, P. L., Velluva, A., Gerada, A., Hughes, D. M., Brookfield, C., . . . Buchan, I. (2024). Bayesian estimation of the prevalence of antimicrobial resistance: a mathematical modelling study.. The Journal of antimicrobial chemotherapy, dkae230. doi:10.1093/jac/dkae230
Bayesian Calibration to Address the Challenge of Antimicrobial Resistance: A Review
Rosato, C., Green, P. L., Harris, J., Maskell, S., Hope, W., Gerada, A., & Howard, A. (2024). Bayesian Calibration to Address the Challenge of Antimicrobial Resistance: A Review. IEEE Access, 12, 100772-100791. doi:10.1109/access.2024.3427410
HAP-FAST: a feasibility study incorporating qualitative, mechanistic and costing sub-studies alongside a randomised pilot trial comparing chest x-ray to low-dose CT scan and empirical antibiotics to antibiotics guided by the BIOFIRE® FILM ARRAY® pneumonia <i>plus</i> panel in adults with suspected non-ventilator-associated hospital-cquired pneumonia.
Shafiqa, N., Aston, S., Howard, A., Turtle, L., Abrams, S., Young, B., . . . Wootton, D. G. (2024). HAP-FAST: a feasibility study incorporating qualitative, mechanistic and costing sub-studies alongside a randomised pilot trial comparing chest x-ray to low-dose CT scan and empirical antibiotics to antibiotics guided by the BIOFIRE® FILM ARRAY® pneumonia <i>plus</i> panel in adults with suspected non-ventilator-associated hospital-cquired pneumonia.. BMJ open, 14(7), e088490. doi:10.1136/bmjopen-2024-088490
Biomarker Driven Antifungal Stewardship (BioDriveAFS) in acute leukaemia-a multi-centre randomised controlled trial to assess clinical and cost effectiveness: a study protocol for a randomised controlled trial.
Flett, L., Abdelatif, R., Baz, S. A., Brady, S., Corbacho, B., Common, K., . . . Barlow, G. (2024). Biomarker Driven Antifungal Stewardship (BioDriveAFS) in acute leukaemia-a multi-centre randomised controlled trial to assess clinical and cost effectiveness: a study protocol for a randomised controlled trial.. Trials, 25(1), 427. doi:10.1186/s13063-024-08272-w
Challenges for global antibiotic regimen planning and establishing antimicrobial resistance targets: implications for the WHO Essential Medicines List and AWaRe antibiotic book dosing.
Reza, N., Gerada, A., Stott, K. E., Howard, A., Sharland, M., & Hope, W. (2024). Challenges for global antibiotic regimen planning and establishing antimicrobial resistance targets: implications for the WHO Essential Medicines List and AWaRe antibiotic book dosing.. Clinical microbiology reviews, 37(2), e0013923. doi:10.1128/cmr.00139-23
System-wide approaches to antimicrobial therapy and antimicrobial resistance in the UK: the AMR-X framework.
AMR-X Collaborators. (2024). System-wide approaches to antimicrobial therapy and antimicrobial resistance in the UK: the AMR-X framework.. The Lancet. Microbe, 5(5), e500-e507. doi:10.1016/s2666-5247(24)00003-x
Determination of minimum inhibitory concentrations using machine-learning-assisted agar dilution.
Gerada, A., Harper, N., Howard, A., Reza, N., & Hope, W. (2024). Determination of minimum inhibitory concentrations using machine-learning-assisted agar dilution.. Microbiology spectrum, e0420923. doi:10.1128/spectrum.04209-23
Antimicrobial learning systems: an implementation blueprint for artificial intelligence to tackle antimicrobial resistance.
Howard, A., Aston, S., Gerada, A., Reza, N., Bincalar, J., Mwandumba, H., . . . Buchan, I. (2024). Antimicrobial learning systems: an implementation blueprint for artificial intelligence to tackle antimicrobial resistance.. The Lancet. Digital health, 6(1), e79-e86. doi:10.1016/s2589-7500(23)00221-2
Antimicrobial treatment imprecision: an outcome-based model to close the data-to-action loop.
Howard, A., Reza, N., Aston, S., Woods, B., Gerada, A., Buchan, I., . . . Märtson, A. -G. (2024). Antimicrobial treatment imprecision: an outcome-based model to close the data-to-action loop.. The Lancet. Infectious diseases, 24(1), e47-e58. doi:10.1016/s1473-3099(23)00367-5
2023
48 Describing the epidemiological characteristics and treatment patterns of non-tuberculosis mycobacteria (NTM) infections in adults in Liverpool 2010–2022
Todd, H., Haigh, K., Frost, F., Green, D., Aston, S., Howard, A., . . . Davies, G. (2023). 48 Describing the epidemiological characteristics and treatment patterns of non-tuberculosis mycobacteria (NTM) infections in adults in Liverpool 2010–2022. Clinical Infection in Practice, 20, 100307. doi:10.1016/j.clinpr.2023.100307
ChatGPT and antimicrobial advice: the end of the consulting infection doctor?
Howard, A., Hope, W., & Gerada, A. (2023). ChatGPT and antimicrobial advice: the end of the consulting infection doctor?. LANCET INFECTIOUS DISEASES, 23(4), 405. doi:10.1016/S1473-3099(23)00113-5
Assessment of Antifungal Pharmacodynamics
Howard, A., & Hope, W. (2023). Assessment of Antifungal Pharmacodynamics. JOURNAL OF FUNGI, 9(2). doi:10.3390/jof9020192
ChatGPT and antimicrobial advice: the end of the consulting infection doctor?
Howard, A., Hope, W., & Gerada, A. (2023). ChatGPT and antimicrobial advice: the end of the consulting infection doctor?. LANCET INFECTIOUS DISEASES, 23(4), 405-406. Retrieved from https://www.webofscience.com/
2022
CON: Serum biomarker monitoring should not replace primary antifungal chemoprophylaxis in patients with acute leukaemia receiving systemic anti-cancer therapy
Howard, A., & Hope, W. (2022). CON: Serum biomarker monitoring should not replace primary antifungal chemoprophylaxis in patients with acute leukaemia receiving systemic anti-cancer therapy. JAC-ANTIMICROBIAL RESISTANCE, 4(4). doi:10.1093/jacamr/dlac081
Can Beta-D-Glucan testing as part of the diagnostic pathway for invasive fungal infection reduce anti-fungal treatment costs?
Hamilton, D. O., Lambe, T., Howard, A., Crossey, P., Hughes, J., Duarte, R., & Welters, I. D. (2022). Can Beta-D-Glucan testing as part of the diagnostic pathway for invasive fungal infection reduce anti-fungal treatment costs?. MEDICAL MYCOLOGY, 60(5). doi:10.1093/mmy/myac034
Piperacillin/tazobactam-resistant, cephalosporin-susceptible <i>Escherichia coli</i> bloodstream infections are driven by multiple acquisition of resistance across diverse sequence types
Edwards, T., Heinz, E., van Aartsen, J., Howard, A., Roberts, P., Corless, C., . . . Hubbard, A. T. M. (2022). Piperacillin/tazobactam-resistant, cephalosporin-susceptible <i>Escherichia coli</i> bloodstream infections are driven by multiple acquisition of resistance across diverse sequence types. MICROBIAL GENOMICS, 8(4). doi:10.1099/mgen.0.000789
2020
Piperacillin/tazobactam resistance in a clinical isolate of <i>Escherichia coli</i> due to IS<i>26</i>-mediated amplification of <i>bla</i><sub>TEM-1B</sub>
Hubbard, A. T. M., Mason, J., Roberts, P., Parry, C. M., Corless, C., van Aartsen, J., . . . Edwards, T. (2020). Piperacillin/tazobactam resistance in a clinical isolate of <i>Escherichia coli</i> due to IS<i>26</i>-mediated amplification of <i>bla</i><sub>TEM-1B</sub>. NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-18668-2
Impact of different carbapenemase-producing Enterobacterales screening strategies in a hospital setting
Corless, C. E., Howard, A. M., & Neal, T. J. (2020). Impact of different carbapenemase-producing Enterobacterales screening strategies in a hospital setting. INFECTION PREVENTION IN PRACTICE, 2(3). doi:10.1016/j.infpip.2019.100011
2015
Diagnosing osteomyelitis in diabetes foot ulceration
Srinivas-Shankar, U., Howard, A. M., Pendlebury, H., Mathews, M., Milligan, K., Ford, N., & Khalathil, D. (2015). Diagnosing osteomyelitis in diabetes foot ulceration. In DIABETIC MEDICINE Vol. 32 (pp. 151). Retrieved from https://www.webofscience.com/