Publications
2023
Elevated Serum Gastrin Is Associated with Melanoma Progression: Putative Role in Increased Migration and Invasion of Melanoma Cells.
Varga, A. J., Nemeth, I. B., Kemeny, L., Varga, J., Tiszlavicz, L., Kumar, D., . . . Varro, A. (2023). Elevated Serum Gastrin Is Associated with Melanoma Progression: Putative Role in Increased Migration and Invasion of Melanoma Cells.. International journal of molecular sciences, 24(23), 16851. doi:10.3390/ijms242316851
2018
Matrix metalloproteinase (MMP)-7 in Barrett's esophagus and esophageal adenocarcinoma: expression, metabolism, and functional significance
Garalla, H. M., Lertkowit, N., Tiszlavicz, L., Reisz, Z., Holmberg, C., Beynon, R., . . . Varro, A. (2018). Matrix metalloproteinase (MMP)-7 in Barrett's esophagus and esophageal adenocarcinoma: expression, metabolism, and functional significance. Retrieved from https://www.webofscience.com/
2017
Cell cycle dependent expression of the CCK2 receptor by gastrointestinal myofibroblasts: putative role in determining cell migration
Varga, A., Kumar, J. D., Simpson, A. W. M., Dodd, S., Hegyi, P., Dockray, G. J., & Varro, A. (2017). Cell cycle dependent expression of the CCK2 receptor by gastrointestinal myofibroblasts: putative role in determining cell migration. PHYSIOLOGICAL REPORTS, 5(19). doi:10.14814/phy2.13394
2010
Dynamic Changes in Cytosolic and Mitochondrial ATP Levels in Pancreatic Acinar Cells
Voronina, S. G., Barrow, S. L., Simpson, A. W. M., Gerasimenko, O. V., Xavier, G. D. S., Rutter, G. A., . . . Tepikin, A. V. (2010). Dynamic Changes in Cytosolic and Mitochondrial ATP Levels in Pancreatic Acinar Cells. GASTROENTEROLOGY, 138(5), 1976-U111. doi:10.1053/j.gastro.2010.01.037
2009
Reply to Sadaba
Conant, A. R., & Simpson, A. W. M. (2009). Reply to Sadaba. European Journal of Cardio-Thoracic Surgery, 35(6), 1116. doi:10.1016/j.ejcts.2009.02.026
Compartmentalized signalling: Ca2+ compartments, microdomains and the many facets of Ca2+ signalling.
Laude, A. J., & Simpson, A. W. M. (2009). Compartmentalized signalling: Ca2+ compartments, microdomains and the many facets of Ca2+ signalling.. The FEBS journal, 276(7), 1800-1816. doi:10.1111/j.1742-4658.2009.06927.x
2008
Attenuation of receptor-dependent and -independent vasoconstriction in the human radial artery
Shackcloth, M. J., Conant, A. R., Thekkudan, J., Ghotkar, S., Simpson, A. W. M., & Dihmis, W. C. (2008). Attenuation of receptor-dependent and -independent vasoconstriction in the human radial artery. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 34(4), 839-844. doi:10.1016/j.ejcts.2008.06.016
Potentiation of ATP- and bradykinin-induced [Ca2+]c responses by PTHrP peptides in the HaCaT cell line.
Burrell, H. E., Simpson, A. W. M., Mehat, S., McCreavy, D. T., Durham, B., Fraser, W. D., . . . Gallagher, J. A. (2008). Potentiation of ATP- and bradykinin-induced [Ca2+]c responses by PTHrP peptides in the HaCaT cell line.. The Journal of investigative dermatology, 128(5), 1107-1115. doi:10.1038/sj.jid.5701159
Diadenosine polyphosphates are selective vasoconstrictors in human coronary artery bypass grafts.
Conant, A. R., Theologou, T., Dihmis, W. C., & Simpson, A. W. M. (2008). Diadenosine polyphosphates are selective vasoconstrictors in human coronary artery bypass grafts.. Vascular pharmacology, 48(4-6), 157-164. doi:10.1016/j.vph.2008.01.005
2007
Atrial natriuretic peptide attenuates elevations in Ca2+ and protects hepatocytes by stimulating net plasma membrane Ca2+ efflux.
Green, A. K., Stratton, R. C., Squires, P. E., & Simpson, A. W. M. (2007). Atrial natriuretic peptide attenuates elevations in Ca2+ and protects hepatocytes by stimulating net plasma membrane Ca2+ efflux.. The Journal of biological chemistry, 282(47), 34542-34554. doi:10.1074/jbc.m707115200
Cell shape-dependent Control of Ca2+ influx and cell cycle progression in Swiss 3T3 fibroblasts.
Pennington, S. R., Foster, B. J., Hawley, S. R., Jenkins, R. E., Zolle, O., White, M. R. H., . . . Simpson, A. W. M. (2007). Cell shape-dependent Control of Ca2+ influx and cell cycle progression in Swiss 3T3 fibroblasts.. The Journal of biological chemistry, 282(44), 32112-32120. doi:10.1074/jbc.m705067200
Temperature changes stimulate contraction in the human radial artery and affect response to vasoconstrictors.
Oo, A. Y., Conant, A. R., Chester, M. R., Dihmis, W. C., & Simpson, A. W. M. (2007). Temperature changes stimulate contraction in the human radial artery and affect response to vasoconstrictors.. The Annals of thoracic surgery, 83(1), 126-132. doi:10.1016/j.athoracsur.2006.08.035
2006
Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes
Goldring, C. E. P., Kitteringham, N. R., Jenkins, R., Lovatt, C. A., Randle, L. E., Abdullah, A., . . . Park, B. K. (2006). Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 290(1), C104-C115. doi:10.1152/ajpcell.00133.2005
Fluorescent measurement of [Ca2+]c: basic practical considerations.
Simpson, A. W. M. (2006). Fluorescent measurement of [Ca2+]c: basic practical considerations.. In Unknown Book (Vol. 312, pp. 3-36).
2005
Human keratinocytes release ATP and utilize three mechanisms for nucleotide interconversion at the cell surface.
Burrell, H. E., Wlodarski, B., Foster, B. J., Buckley, K. A., Sharpe, G. R., Quayle, J. M., . . . Gallagher, J. A. (2005). Human keratinocytes release ATP and utilize three mechanisms for nucleotide interconversion at the cell surface.. The Journal of biological chemistry, 280(33), 29667-29676. doi:10.1074/jbc.m505381200
Antioxidant enzyme activity in cultured human arterial and venous endothelial cells
Conant, A. R., Dihimis, W. C., & Simpson, A. W. M. (2005). Antioxidant enzyme activity in cultured human arterial and venous endothelial cells. Heart, 91(7).
2003
Regulation of [Ca2+]c oscillations by plasma membrane Ca2+ fluxes: a role for natriuretic peptides.
Green, A. K., Zolle, O., & Simpson, A. W. M. (2003). Regulation of [Ca2+]c oscillations by plasma membrane Ca2+ fluxes: a role for natriuretic peptides.. Biochemical Society transactions, 31(Pt 5), 934-938. doi:10.1042/bst0310934
Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery: The effect of other vasodilators
Conant, A. R., Shackcloth, M. J., Oo, A. Y., Chester, M. R., Simpson, A. W. M., & Dihmis, W. C. (2003). Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery: The effect of other vasodilators. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 126(2), 448-454. doi:10.1016/S0022-5223(03)00388-X
Regulation of [Ca2+](c) oscillations by plasma membrane Ca2+ fluxes: a role for natriuretic peptides
Green, A. K., Zolle, O., & Simpson, A. W. M. (2003). Regulation of [Ca2+](c) oscillations by plasma membrane Ca2+ fluxes: a role for natriuretic peptides. Biochemical Society Transactions, 31, 934-938.
2002
Atrial natriuretic peptide attenuates Ca2+ oscillations and modulates plasma membrane Ca2+ fluxes in rat hepatocytes.
Green, A. K., Zolle, O., & Simpson, A. W. M. (2002). Atrial natriuretic peptide attenuates Ca2+ oscillations and modulates plasma membrane Ca2+ fluxes in rat hepatocytes.. Gastroenterology, 123(4), 1291-1303. doi:10.1053/gast.2002.35994
Endothelin receptors in cultured and native human radial artery smooth muscle.
Conant, A. R., Oo, A. Y., Dashwood, M. R., Collard, K., Chester, M. R., Dihmis, W. C., & Simpson, A. W. M. (2002). Endothelin receptors in cultured and native human radial artery smooth muscle.. Journal of cardiovascular pharmacology, 39(1), 130-141. doi:10.1097/00005344-200201000-00014
Modulation of contractility in phenoxybenzamine-treated human radial arteries prepared for coronary artery bypass surgery
Shackcloth, M. J., Oo, A. Y., Chester, M. R., Simpson, A. W. M., Dihmis, W. C., & Conant, A. R. (2002). Modulation of contractility in phenoxybenzamine-treated human radial arteries prepared for coronary artery bypass surgery. Journal Of Physiology-London, 543, 72P.
Temperature-induced contraction in human radial artery smooth muscle
Oo, A. Y., Conant, A. R., Chester, M. R., Dihmis, W. C., & Simpson, A. W. M. (2002). Temperature-induced contraction in human radial artery smooth muscle. Journal Of Physiology-London, 543, 72P.
2001
A fluorescence-based method for measuring nitric oxide in extracts of skeletal muscle.
Sutherland, H., Khundkar, R., Zolle, O., McArdle, A., Simpson, A. W., Jarvis, J. C., & Salmons, S. (2001). A fluorescence-based method for measuring nitric oxide in extracts of skeletal muscle.. Nitric oxide : biology and chemistry, 5(5), 475-481. doi:10.1006/niox.2001.0374
2000
Diadenosine polyphosphates are largely ineffective as agonists at natively expressed P2Y(1) and P2Y(2) receptors on cultured human saphenous vein endothelial cells.
Conant, A. R., Fisher, M. J., McLennan, A. G., & Simpson, A. W. (2000). Diadenosine polyphosphates are largely ineffective as agonists at natively expressed P2Y(1) and P2Y(2) receptors on cultured human saphenous vein endothelial cells.. Journal of vascular research, 37(6), 548-555. doi:10.1159/000054088
Activation of the particulate and not the soluble guanylate cyclase leads to the inhibition of Ca2+ extrusion through localized elevation of cGMP.
Zolle, O., Lawrie, A. M., & Simpson, A. W. (2000). Activation of the particulate and not the soluble guanylate cyclase leads to the inhibition of Ca2+ extrusion through localized elevation of cGMP.. The Journal of biological chemistry, 275(34), 25892-25899. doi:10.1074/jbc.m000786200
Elevation of mitochondrial calcium by ryanodine-sensitive calcium-induced calcium release.
Nassar, A., & Simpson, A. W. (2000). Elevation of mitochondrial calcium by ryanodine-sensitive calcium-induced calcium release.. The Journal of biological chemistry, 275(31), 23661-23665. doi:10.1074/jbc.m000457200
Cultured human saphenous vein endothelial cells are largely unresponsive to the diadenosine polyphosphates via the natively expressed P2Y receptors.
Conant, A., Fisher, M. J., McLennan, A. G., & Simpson, A. W. M. (2000). Cultured human saphenous vein endothelial cells are largely unresponsive to the diadenosine polyphosphates via the natively expressed P2Y receptors.. In Journal of Physiology-Paris Vol. 525 (pp. 84p). Elsevier.
Cultured human saphenous vein endothelial cells are largely unresponsive to the diadenosine polyphosphates via the natively expressed P2Y receptors
Conant, A. R., Fisher, M. J., McLennan, A. G., & Simpson, A. W. M. (2000). Cultured human saphenous vein endothelial cells are largely unresponsive to the diadenosine polyphosphates via the natively expressed P2Y receptors. Journal Of Physiology-London, 525, 84P.
Elevation of mitochondrial Ca2+ concentration by Ca2+-induced Ca2+ release in the A10 rat aortic smooth muscle cell line
Nassar, A., & Simpson, A. W. M. (2000). Elevation of mitochondrial Ca2+ concentration by Ca2+-induced Ca2+ release in the A10 rat aortic smooth muscle cell line. Journal Of Physiology-London, 525, 84P-85P.
Endothelin increases calcium via Et-A receptors in cultured human radial artery smooth muscle cells
Oo, A. Y., Conant, A. R., Chester, M. R., Dihmis, W. C., & Simpson, A. W. M. (2000). Endothelin increases calcium via Et-A receptors in cultured human radial artery smooth muscle cells. Journal Of Physiology-London, 525, 19P.
1998
Characterization of the P2 receptors on the human umbilical vein endothelial cell line ECV304.
Conant, A. R., Fisher, M. J., McLennan, A. G., & Simpson, A. W. (1998). Characterization of the P2 receptors on the human umbilical vein endothelial cell line ECV304.. British journal of pharmacology, 125(2), 357-364. doi:10.1038/sj.bjp.0702082
A comparison of the purinoceptor populations of primary human umbilical vein endothelial cells and the derived cell line ECV304
Conant, A. R., Fisher, M. J., McLennan, A. G., & Simpson, A. W. M. (1998). A comparison of the purinoceptor populations of primary human umbilical vein endothelial cells and the derived cell line ECV304. In Journal of Physiology-Paris Vol. 506 (pp. 33p-34p). Elsevier.
A comparison of the purinoceptor populations of primary human umbilical vein endothelial cells and the derived cell line ECV304
Conant, A. R., Fisher, M. J., McLennan, A. G., & Simpson, A. W. M. (1998). A comparison of the purinoceptor populations of primary human umbilical vein endothelial cells and the derived cell line ECV304. Journal Of Physiology-London, 506P, 33P-34P.
Activation of adenylate cyclase and PKA can mediate Ca2+ release in cultured ECV304 endothelial cells derived from the human umbilical vein
Hepworth, T. J., & Simpson, A. W. M. (1998). Activation of adenylate cyclase and PKA can mediate Ca2+ release in cultured ECV304 endothelial cells derived from the human umbilical vein. Journal Of Physiology-London, 506P, 19P-20P.
Cell shape regulates bombesin-activated capacitative calcium entry
Hawley, S. R., Zolle, O. C., Spiller, D. G., Wood, C. D., White, M. R. H., Simpson, A. W. M., & Pennington, S. R. (1998). Cell shape regulates bombesin-activated capacitative calcium entry. Molecular Biology Of The Cell, 9, 251A.
Cyclic GMP inhibits calcium extrusion from ECV304 endothelial cells derived from the human umbilical vein
Zolle, O. C., Lawrie, A. M., & Simpson, A. W. M. (1998). Cyclic GMP inhibits calcium extrusion from ECV304 endothelial cells derived from the human umbilical vein. Journal Of Physiology-London, 506P, 20P.
1997
Modulation of mitochondrial Ca2+ in ECV304 endothelial cells by agents which elevate cAMP.
Lawrie, A. M., Zolle, O., & Simpson, A. W. (1997). Modulation of mitochondrial Ca2+ in ECV304 endothelial cells by agents which elevate cAMP.. Cell calcium, 22(4), 229-234. doi:10.1016/s0143-4160(97)90061-0
Okadaic acid induces the release of Ca2+ from intracellular stores in ECV304 endothelial cells.
Hepworth, T. J., Lawrie, A. M., & Simpson, A. W. (1997). Okadaic acid induces the release of Ca2+ from intracellular stores in ECV304 endothelial cells.. Cell calcium, 21(6), 461-467. doi:10.1016/s0143-4160(97)90057-9
Calcium release from ATP-sensitive stores, evoked by okadaic acid in the human umbilical vein endothelial cell line, ECV 304
Hepworth, T. J., Lawrie, A. M., & Simpson, A. W. M. (1997). Calcium release from ATP-sensitive stores, evoked by okadaic acid in the human umbilical vein endothelial cell line, ECV 304. Journal Of Physiology-London, 499P, P42-P43.
1996
A role for calcium influx in the regulation of mitochondrial calcium in endothelial cells.
Lawrie, A. M., Rizzuto, R., Pozzan, T., & Simpson, A. W. (1996). A role for calcium influx in the regulation of mitochondrial calcium in endothelial cells.. The Journal of biological chemistry, 271(18), 10753-10759. doi:10.1074/jbc.271.18.10753
1994
Atp-Evoked Ca2+ Influx In A Human Endothelial-Cell Line Elevates Mitochondrial Calcium As Revealed By Selectively Targeted Recombinant Aequorin
Lawrie, A. M., Rizzuto, R., Pozzan, T., & Simpson, A. W. M. (1994). Atp-Evoked Ca2+ Influx In A Human Endothelial-Cell Line Elevates Mitochondrial Calcium As Revealed By Selectively Targeted Recombinant Aequorin. Journal Of Physiology-London, 480P, P134-P135.
Ca2+ Store Depletion Elevates Intracellular [Na+] In Human Platelets
Simpson, A. W. M., Jilani, S., & Ashley, C. C. (1994). Ca2+ Store Depletion Elevates Intracellular [Na+] In Human Platelets. Journal Of Physiology-London, 477P, P10-P11.
1992
Correction: Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin
Rizzuto, R., Simpson, A. W. M., Brini, M., & Pozzan, T. (1992). Correction: Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin. Nature, 360(6406), 768. doi:10.1038/360768f0
Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin.
Rizzuto, R., Simpson, A. W., Brini, M., & Pozzan, T. (1992). Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin.. Nature, 358(6384), 325-327. doi:10.1038/358325a0
1990
Evidence for receptor-mediated bivalent-cation entry in A10 vascular smooth-muscle cells.
Simpson, A. W., Stampfl, A., & Ashley, C. C. (1990). Evidence for receptor-mediated bivalent-cation entry in A10 vascular smooth-muscle cells.. The Biochemical journal, 267(1), 277-280. doi:10.1042/bj2670277
1989
Endothelin evoked Ca2+ transients and oscillations in A10 vascular smooth muscle cells.
Simpson, A. W., & Ashley, C. C. (1989). Endothelin evoked Ca2+ transients and oscillations in A10 vascular smooth muscle cells.. Biochemical and biophysical research communications, 163(3), 1223-1229. doi:10.1016/0006-291x(89)91108-x
Spontaneous Oscillations and Agonist-Evoked Changes in Ca2+ in Cultured Smooth Muscle Cells
Simpson, A. W. M., & Ashley, C. C. (1989). Spontaneous Oscillations and Agonist-Evoked Changes in Ca2+ in Cultured Smooth Muscle Cells. Journal of Cardiovascular Pharmacology, 14, S59-S62. doi:10.1097/00005344-198900146-00013
1985
Control and interrelation of aggregation and secretion; the roles of Ca2+, diacylglycerol and thromboxane with particular reference to ADP stimulation.
Hallam, T. J., Simpson, A. W., O'Connor, N., & Rink, T. J. (1985). Control and interrelation of aggregation and secretion; the roles of Ca2+, diacylglycerol and thromboxane with particular reference to ADP stimulation.. In Unknown Book (Vol. 192, pp. 145-162). doi:10.1007/978-1-4615-9442-0_11