Skip to main content

Dr Alec Simpson

Publications

What type of publication do you want to show?

2023

2018

2017

2010

Dynamic Changes in Cytosolic and Mitochondrial ATP Levels in Pancreatic Acinar Cells

Voronina, S. G., Barrow, S. L., Simpson, A. W. M., Gerasimenko, O. V., Xavier, G. D. S., Rutter, G. A., . . . Tepikin, A. V. (2010). Dynamic Changes in Cytosolic and Mitochondrial ATP Levels in Pancreatic Acinar Cells. GASTROENTEROLOGY, 138(5), 1976-U111. doi:10.1053/j.gastro.2010.01.037

DOI
10.1053/j.gastro.2010.01.037
Journal article

2009

Reply to Sadaba

Conant, A. R., & Simpson, A. W. M. (2009). Reply to Sadaba. European Journal of Cardio-Thoracic Surgery, 35(6), 1116. doi:10.1016/j.ejcts.2009.02.026

DOI
10.1016/j.ejcts.2009.02.026
Journal article

Compartmentalized signalling: Ca2+ compartments, microdomains and the many facets of Ca2+ signalling.

Laude, A. J., & Simpson, A. W. M. (2009). Compartmentalized signalling: Ca2+ compartments, microdomains and the many facets of Ca2+ signalling.. The FEBS journal, 276(7), 1800-1816. doi:10.1111/j.1742-4658.2009.06927.x

DOI
10.1111/j.1742-4658.2009.06927.x
Journal article

2008

Attenuation of receptor-dependent and -independent vasoconstriction in the human radial artery

Shackcloth, M. J., Conant, A. R., Thekkudan, J., Ghotkar, S., Simpson, A. W. M., & Dihmis, W. C. (2008). Attenuation of receptor-dependent and -independent vasoconstriction in the human radial artery. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 34(4), 839-844. doi:10.1016/j.ejcts.2008.06.016

DOI
10.1016/j.ejcts.2008.06.016
Journal article

Potentiation of ATP- and bradykinin-induced [Ca2+]c responses by PTHrP peptides in the HaCaT cell line.

Burrell, H. E., Simpson, A. W. M., Mehat, S., McCreavy, D. T., Durham, B., Fraser, W. D., . . . Gallagher, J. A. (2008). Potentiation of ATP- and bradykinin-induced [Ca2+]c responses by PTHrP peptides in the HaCaT cell line.. The Journal of investigative dermatology, 128(5), 1107-1115. doi:10.1038/sj.jid.5701159

DOI
10.1038/sj.jid.5701159
Journal article

Diadenosine polyphosphates are selective vasoconstrictors in human coronary artery bypass grafts.

Conant, A. R., Theologou, T., Dihmis, W. C., & Simpson, A. W. M. (2008). Diadenosine polyphosphates are selective vasoconstrictors in human coronary artery bypass grafts.. Vascular pharmacology, 48(4-6), 157-164. doi:10.1016/j.vph.2008.01.005

DOI
10.1016/j.vph.2008.01.005
Journal article

2007

Atrial natriuretic peptide attenuates elevations in Ca2+ and protects hepatocytes by stimulating net plasma membrane Ca2+ efflux.

Green, A. K., Stratton, R. C., Squires, P. E., & Simpson, A. W. M. (2007). Atrial natriuretic peptide attenuates elevations in Ca2+ and protects hepatocytes by stimulating net plasma membrane Ca2+ efflux.. The Journal of biological chemistry, 282(47), 34542-34554. doi:10.1074/jbc.m707115200

DOI
10.1074/jbc.m707115200
Journal article

Cell shape-dependent Control of Ca2+ influx and cell cycle progression in Swiss 3T3 fibroblasts.

Pennington, S. R., Foster, B. J., Hawley, S. R., Jenkins, R. E., Zolle, O., White, M. R. H., . . . Simpson, A. W. M. (2007). Cell shape-dependent Control of Ca2+ influx and cell cycle progression in Swiss 3T3 fibroblasts.. The Journal of biological chemistry, 282(44), 32112-32120. doi:10.1074/jbc.m705067200

DOI
10.1074/jbc.m705067200
Journal article

Temperature changes stimulate contraction in the human radial artery and affect response to vasoconstrictors.

Oo, A. Y., Conant, A. R., Chester, M. R., Dihmis, W. C., & Simpson, A. W. M. (2007). Temperature changes stimulate contraction in the human radial artery and affect response to vasoconstrictors.. The Annals of thoracic surgery, 83(1), 126-132. doi:10.1016/j.athoracsur.2006.08.035

DOI
10.1016/j.athoracsur.2006.08.035
Journal article

2006

Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes

Goldring, C. E. P., Kitteringham, N. R., Jenkins, R., Lovatt, C. A., Randle, L. E., Abdullah, A., . . . Park, B. K. (2006). Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 290(1), C104-C115. doi:10.1152/ajpcell.00133.2005

DOI
10.1152/ajpcell.00133.2005
Journal article

Fluorescent measurement of [Ca2+]c: basic practical considerations.

Simpson, A. W. M. (2006). Fluorescent measurement of [Ca2+]c: basic practical considerations.. In Unknown Book (Vol. 312, pp. 3-36).

Chapter

2005

Human keratinocytes release ATP and utilize three mechanisms for nucleotide interconversion at the cell surface.

Burrell, H. E., Wlodarski, B., Foster, B. J., Buckley, K. A., Sharpe, G. R., Quayle, J. M., . . . Gallagher, J. A. (2005). Human keratinocytes release ATP and utilize three mechanisms for nucleotide interconversion at the cell surface.. The Journal of biological chemistry, 280(33), 29667-29676. doi:10.1074/jbc.m505381200

DOI
10.1074/jbc.m505381200
Journal article

Antioxidant enzyme activity in cultured human arterial and venous endothelial cells

Conant, A. R., Dihimis, W. C., & Simpson, A. W. M. (2005). Antioxidant enzyme activity in cultured human arterial and venous endothelial cells. Heart, 91(7).

Journal article

2003

Regulation of [Ca2+]c oscillations by plasma membrane Ca2+ fluxes: a role for natriuretic peptides.

Green, A. K., Zolle, O., & Simpson, A. W. M. (2003). Regulation of [Ca2+]c oscillations by plasma membrane Ca2+ fluxes: a role for natriuretic peptides.. Biochemical Society transactions, 31(Pt 5), 934-938. doi:10.1042/bst0310934

DOI
10.1042/bst0310934
Journal article

Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery: The effect of other vasodilators

Conant, A. R., Shackcloth, M. J., Oo, A. Y., Chester, M. R., Simpson, A. W. M., & Dihmis, W. C. (2003). Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery: The effect of other vasodilators. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 126(2), 448-454. doi:10.1016/S0022-5223(03)00388-X

DOI
10.1016/S0022-5223(03)00388-X
Journal article

Regulation of [Ca2+](c) oscillations by plasma membrane Ca2+ fluxes: a role for natriuretic peptides

Green, A. K., Zolle, O., & Simpson, A. W. M. (2003). Regulation of [Ca2+](c) oscillations by plasma membrane Ca2+ fluxes: a role for natriuretic peptides. Biochemical Society Transactions, 31, 934-938.

Journal article

2002

Atrial natriuretic peptide attenuates Ca2+ oscillations and modulates plasma membrane Ca2+ fluxes in rat hepatocytes.

Green, A. K., Zolle, O., & Simpson, A. W. M. (2002). Atrial natriuretic peptide attenuates Ca2+ oscillations and modulates plasma membrane Ca2+ fluxes in rat hepatocytes.. Gastroenterology, 123(4), 1291-1303. doi:10.1053/gast.2002.35994

DOI
10.1053/gast.2002.35994
Journal article

Endothelin receptors in cultured and native human radial artery smooth muscle.

Conant, A. R., Oo, A. Y., Dashwood, M. R., Collard, K., Chester, M. R., Dihmis, W. C., & Simpson, A. W. M. (2002). Endothelin receptors in cultured and native human radial artery smooth muscle.. Journal of cardiovascular pharmacology, 39(1), 130-141. doi:10.1097/00005344-200201000-00014

DOI
10.1097/00005344-200201000-00014
Journal article

Modulation of contractility in phenoxybenzamine-treated human radial arteries prepared for coronary artery bypass surgery

Shackcloth, M. J., Oo, A. Y., Chester, M. R., Simpson, A. W. M., Dihmis, W. C., & Conant, A. R. (2002). Modulation of contractility in phenoxybenzamine-treated human radial arteries prepared for coronary artery bypass surgery. Journal Of Physiology-London, 543, 72P.

Journal article

Temperature-induced contraction in human radial artery smooth muscle

Oo, A. Y., Conant, A. R., Chester, M. R., Dihmis, W. C., & Simpson, A. W. M. (2002). Temperature-induced contraction in human radial artery smooth muscle. Journal Of Physiology-London, 543, 72P.

Journal article

2001

A fluorescence-based method for measuring nitric oxide in extracts of skeletal muscle.

Sutherland, H., Khundkar, R., Zolle, O., McArdle, A., Simpson, A. W., Jarvis, J. C., & Salmons, S. (2001). A fluorescence-based method for measuring nitric oxide in extracts of skeletal muscle.. Nitric oxide : biology and chemistry, 5(5), 475-481. doi:10.1006/niox.2001.0374

DOI
10.1006/niox.2001.0374
Journal article

2000

Diadenosine polyphosphates are largely ineffective as agonists at natively expressed P2Y(1) and P2Y(2) receptors on cultured human saphenous vein endothelial cells.

Conant, A. R., Fisher, M. J., McLennan, A. G., & Simpson, A. W. (2000). Diadenosine polyphosphates are largely ineffective as agonists at natively expressed P2Y(1) and P2Y(2) receptors on cultured human saphenous vein endothelial cells.. Journal of vascular research, 37(6), 548-555. doi:10.1159/000054088

DOI
10.1159/000054088
Journal article

Activation of the particulate and not the soluble guanylate cyclase leads to the inhibition of Ca2+ extrusion through localized elevation of cGMP.

Zolle, O., Lawrie, A. M., & Simpson, A. W. (2000). Activation of the particulate and not the soluble guanylate cyclase leads to the inhibition of Ca2+ extrusion through localized elevation of cGMP.. The Journal of biological chemistry, 275(34), 25892-25899. doi:10.1074/jbc.m000786200

DOI
10.1074/jbc.m000786200
Journal article

Elevation of mitochondrial calcium by ryanodine-sensitive calcium-induced calcium release.

Nassar, A., & Simpson, A. W. (2000). Elevation of mitochondrial calcium by ryanodine-sensitive calcium-induced calcium release.. The Journal of biological chemistry, 275(31), 23661-23665. doi:10.1074/jbc.m000457200

DOI
10.1074/jbc.m000457200
Journal article

Cultured human saphenous vein endothelial cells are largely unresponsive to the diadenosine polyphosphates via the natively expressed P2Y receptors.

Conant, A., Fisher, M. J., McLennan, A. G., & Simpson, A. W. M. (2000). Cultured human saphenous vein endothelial cells are largely unresponsive to the diadenosine polyphosphates via the natively expressed P2Y receptors.. In Journal of Physiology-Paris Vol. 525 (pp. 84p). Elsevier.

Conference Paper

Cultured human saphenous vein endothelial cells are largely unresponsive to the diadenosine polyphosphates via the natively expressed P2Y receptors

Conant, A. R., Fisher, M. J., McLennan, A. G., & Simpson, A. W. M. (2000). Cultured human saphenous vein endothelial cells are largely unresponsive to the diadenosine polyphosphates via the natively expressed P2Y receptors. Journal Of Physiology-London, 525, 84P.

Journal article

Elevation of mitochondrial Ca2+ concentration by Ca2+-induced Ca2+ release in the A10 rat aortic smooth muscle cell line

Nassar, A., & Simpson, A. W. M. (2000). Elevation of mitochondrial Ca2+ concentration by Ca2+-induced Ca2+ release in the A10 rat aortic smooth muscle cell line. Journal Of Physiology-London, 525, 84P-85P.

Journal article

Endothelin increases calcium via Et-A receptors in cultured human radial artery smooth muscle cells

Oo, A. Y., Conant, A. R., Chester, M. R., Dihmis, W. C., & Simpson, A. W. M. (2000). Endothelin increases calcium via Et-A receptors in cultured human radial artery smooth muscle cells. Journal Of Physiology-London, 525, 19P.

Journal article

1998

Characterization of the P2 receptors on the human umbilical vein endothelial cell line ECV304.

Conant, A. R., Fisher, M. J., McLennan, A. G., & Simpson, A. W. (1998). Characterization of the P2 receptors on the human umbilical vein endothelial cell line ECV304.. British journal of pharmacology, 125(2), 357-364. doi:10.1038/sj.bjp.0702082

DOI
10.1038/sj.bjp.0702082
Journal article

A comparison of the purinoceptor populations of primary human umbilical vein endothelial cells and the derived cell line ECV304

Conant, A. R., Fisher, M. J., McLennan, A. G., & Simpson, A. W. M. (1998). A comparison of the purinoceptor populations of primary human umbilical vein endothelial cells and the derived cell line ECV304. In Journal of Physiology-Paris Vol. 506 (pp. 33p-34p). Elsevier.

Conference Paper

A comparison of the purinoceptor populations of primary human umbilical vein endothelial cells and the derived cell line ECV304

Conant, A. R., Fisher, M. J., McLennan, A. G., & Simpson, A. W. M. (1998). A comparison of the purinoceptor populations of primary human umbilical vein endothelial cells and the derived cell line ECV304. Journal Of Physiology-London, 506P, 33P-34P.

Journal article

Activation of adenylate cyclase and PKA can mediate Ca2+ release in cultured ECV304 endothelial cells derived from the human umbilical vein

Hepworth, T. J., & Simpson, A. W. M. (1998). Activation of adenylate cyclase and PKA can mediate Ca2+ release in cultured ECV304 endothelial cells derived from the human umbilical vein. Journal Of Physiology-London, 506P, 19P-20P.

Journal article

Cell shape regulates bombesin-activated capacitative calcium entry

Hawley, S. R., Zolle, O. C., Spiller, D. G., Wood, C. D., White, M. R. H., Simpson, A. W. M., & Pennington, S. R. (1998). Cell shape regulates bombesin-activated capacitative calcium entry. Molecular Biology Of The Cell, 9, 251A.

Journal article

Cyclic GMP inhibits calcium extrusion from ECV304 endothelial cells derived from the human umbilical vein

Zolle, O. C., Lawrie, A. M., & Simpson, A. W. M. (1998). Cyclic GMP inhibits calcium extrusion from ECV304 endothelial cells derived from the human umbilical vein. Journal Of Physiology-London, 506P, 20P.

Journal article

1997

Modulation of mitochondrial Ca2+ in ECV304 endothelial cells by agents which elevate cAMP.

Lawrie, A. M., Zolle, O., & Simpson, A. W. (1997). Modulation of mitochondrial Ca2+ in ECV304 endothelial cells by agents which elevate cAMP.. Cell calcium, 22(4), 229-234. doi:10.1016/s0143-4160(97)90061-0

DOI
10.1016/s0143-4160(97)90061-0
Journal article

Okadaic acid induces the release of Ca2+ from intracellular stores in ECV304 endothelial cells.

Hepworth, T. J., Lawrie, A. M., & Simpson, A. W. (1997). Okadaic acid induces the release of Ca2+ from intracellular stores in ECV304 endothelial cells.. Cell calcium, 21(6), 461-467. doi:10.1016/s0143-4160(97)90057-9

DOI
10.1016/s0143-4160(97)90057-9
Journal article

Calcium release from ATP-sensitive stores, evoked by okadaic acid in the human umbilical vein endothelial cell line, ECV 304

Hepworth, T. J., Lawrie, A. M., & Simpson, A. W. M. (1997). Calcium release from ATP-sensitive stores, evoked by okadaic acid in the human umbilical vein endothelial cell line, ECV 304. Journal Of Physiology-London, 499P, P42-P43.

Journal article

1996

A role for calcium influx in the regulation of mitochondrial calcium in endothelial cells.

Lawrie, A. M., Rizzuto, R., Pozzan, T., & Simpson, A. W. (1996). A role for calcium influx in the regulation of mitochondrial calcium in endothelial cells.. The Journal of biological chemistry, 271(18), 10753-10759. doi:10.1074/jbc.271.18.10753

DOI
10.1074/jbc.271.18.10753
Journal article

1994

Atp-Evoked Ca2+ Influx In A Human Endothelial-Cell Line Elevates Mitochondrial Calcium As Revealed By Selectively Targeted Recombinant Aequorin

Lawrie, A. M., Rizzuto, R., Pozzan, T., & Simpson, A. W. M. (1994). Atp-Evoked Ca2+ Influx In A Human Endothelial-Cell Line Elevates Mitochondrial Calcium As Revealed By Selectively Targeted Recombinant Aequorin. Journal Of Physiology-London, 480P, P134-P135.

Journal article

Ca2+ Store Depletion Elevates Intracellular [Na+] In Human Platelets

Simpson, A. W. M., Jilani, S., & Ashley, C. C. (1994). Ca2+ Store Depletion Elevates Intracellular [Na+] In Human Platelets. Journal Of Physiology-London, 477P, P10-P11.

Journal article

1992

Correction: Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin

Rizzuto, R., Simpson, A. W. M., Brini, M., & Pozzan, T. (1992). Correction: Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin. Nature, 360(6406), 768. doi:10.1038/360768f0

DOI
10.1038/360768f0
Journal article

Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin.

Rizzuto, R., Simpson, A. W., Brini, M., & Pozzan, T. (1992). Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin.. Nature, 358(6384), 325-327. doi:10.1038/358325a0

DOI
10.1038/358325a0
Journal article

1990

Evidence for receptor-mediated bivalent-cation entry in A10 vascular smooth-muscle cells.

Simpson, A. W., Stampfl, A., & Ashley, C. C. (1990). Evidence for receptor-mediated bivalent-cation entry in A10 vascular smooth-muscle cells.. The Biochemical journal, 267(1), 277-280. doi:10.1042/bj2670277

DOI
10.1042/bj2670277
Journal article

1989

Endothelin evoked Ca2+ transients and oscillations in A10 vascular smooth muscle cells.

Simpson, A. W., & Ashley, C. C. (1989). Endothelin evoked Ca2+ transients and oscillations in A10 vascular smooth muscle cells.. Biochemical and biophysical research communications, 163(3), 1223-1229. doi:10.1016/0006-291x(89)91108-x

DOI
10.1016/0006-291x(89)91108-x
Journal article

Spontaneous Oscillations and Agonist-Evoked Changes in Ca2+ in Cultured Smooth Muscle Cells

Simpson, A. W. M., & Ashley, C. C. (1989). Spontaneous Oscillations and Agonist-Evoked Changes in Ca2+ in Cultured Smooth Muscle Cells. Journal of Cardiovascular Pharmacology, 14, S59-S62. doi:10.1097/00005344-198900146-00013

DOI
10.1097/00005344-198900146-00013
Journal article

1985

Control and interrelation of aggregation and secretion; the roles of Ca2+, diacylglycerol and thromboxane with particular reference to ADP stimulation.

Hallam, T. J., Simpson, A. W., O'Connor, N., & Rink, T. J. (1985). Control and interrelation of aggregation and secretion; the roles of Ca2+, diacylglycerol and thromboxane with particular reference to ADP stimulation.. In Unknown Book (Vol. 192, pp. 145-162). doi:10.1007/978-1-4615-9442-0_11

DOI
10.1007/978-1-4615-9442-0_11
Chapter