Receptors and receptive fields

The Reverend Dr. David CM Taylor dcmt@liverpool.ac.uk

This page is © David Taylor and The University of Liverpool, 1999

This is covered well in

 Chapter 6 of Bray (Bray, Cragg, MacKnight, Mills & Taylor, Lecture Notes on Human Physiology 3rd Edition, 1994 Blackwell Scientific Publications),

 Chapter 4 of Carpenter (Carpenter, RHS, Neurophysiology 3rd Edition 1996, Arnold)

 Chapters 23 - 26 of Kandel (Kandel, Schwartz & Jessell, Principles of Neural Science 3rd Edition, 1991, Elsevier)

As ever in neurophysiology, try not to get bogged down with the anatomy.

 

Five senses ?

This was a concept introduced by the ancient Greeks, and has little to recommend it. The main senses are shown below. Many neurophysiologists would include proprioception in the list - particularly the muscle receptors.

 hearing

 sight

 touch

 taste, smell

 temperature

 pain

 balance, posture

Transduction

The simplest form of transduction is that shown by the molecular receptor, for instance those involved with

 taste

 smell

 chemoreception

 vision

 nociception

 The binding of a molecule to a receptor causes a conformational change which results in a graded receptor potential

 

The alternatively, the deformation of the terminal region of the neurone can lead to a graded receptor potential as is the case in

 mechanoreception

 balance

 hearing

 joint receptors

 muscle spindles

 nociception

 

A further alternative is when a change in temperature shifts the balance between an inhibitory process (e.g. the sodium/potassium pump) and an excitatory process (e.g. the inward "leakage" of calcium).

Transduction mechanisms are covered in Chapter 3 of Carpenter and chapter 23 of Kandel. But the level at which they have been covered in the lectures is as deep as you need to go. Provided, that is, that you understand the Generator potential in terms of ionic mechanisms (Nernst equation and so on). Once a threshold potential is reached, then the voltage activate sodium channels open in the usual way, and an action potential, or train of action potentials occur.

 

Receptive Fields

 may be large or small, depending upon the amount of branching of the peripheral nerve

 and the nature and depth of the receptor

You should try to relate the location and the anatomy of the receptors to their characteristics described in most physiology textbooks.


Responses

 adaptation - rapid or slow

 Pacinian Corpuscles vs Merkel Cells

 static and/or dynamic

 joint and thermal receptors

 linear or bell shaped

 again like joint or thermal receptors

 

These are treated well in most physiology textbooks. The one important detail that you should know, as mentioned in the lectures, is the observation that different sensory modalities are transmitted along fibres of different diameter and conduction velocity. This has consequences in the way that different sensations are perceived, it also means that if we know the conduction velocity of a given fibre we can predict the sensory modality it carries.

 

The Table below is derived from Bray (p.143) and Carpenter (p.32). Carpenter is especially good on this topic.

fibre type

numerical equivalent

Diameter m m

Velocity

m/s

receptors

modalities

Ab

I and II

4 - 16

30 - 70

Merkel cells, Ruffini endings, Meissner and Pacinian corpuscles, larger hairs

Touch pressure, vibration, position sense

Ad

III

1 - 4

3 - 30

small hairs, free nerve endings

touch, pressure, cold, pricking (1st) pain. Also 2nd pain in humans

C

IV

0.5 - 2

unmyelinated

< 2

thermoreceptors and nociceptors

cold, warmth and dull pain 2nd

 

 

 

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