Largest losses of life at sea in Irish Sea region

Irish Sea area here taken as:
Southern edge: Carnsore Point to St. Davids Head; Northern edge: Larne to Corsewall Point.
[The largest single loss, of 1250 people, on the torpedoed RMS Lusitania 1915, was outside this region].

Losses of over 100 people.
  Holyhead Packet 1670 foundered, 122 lost
  HMS Enterprise 1707 aground, Blackpool, up to 115 lost.
  Neptune 1748 aground, Hoyle bank, over 100 lost
  French warships 1760, battle, Isle of Man, 300 lost.
  Nonpareil 1775 aground, Hoyle bank, over 100 lost
  Belgioioso 1783 aground, Kish Bank, 147 lost
  Charlemont 1790 aground, Holyhead, 110 lost
  Pelican 1793 foundered, Mersey, 102 lost
  King George 1805 aground, Dee, 125 lost
  Prince of Wales 1807 aground, Dublin, 120 lost
  Rochdale 1807 aground, Dublin, 265 lost
  Alert 1823 aground, Anglesey, 100 lost.
  PS Rothsay Castle 1831 aground, Menai Straits, 113-123 lost
  Jane and Margaret 1837 aground, Arklow Bank, 206 lost
  Governor Fenner 1841 collision, off Anglesey, 123 lost
  Ocean Monarch 1848 fire, Liverpool Bay, 178 lost
  Tayleur 1854 aground, Lambay Island, 380 lost
  Pomona 1859 aground, Blackwater Bank, 424 lost
  Royal Charter 1859 aground, Moelfre, 450 lost
  HMS Bayano 1915 sunk by U-27, NW of Corsewall Point, 196 lost
  SS Burutu 1918 collision, Irish Sea, 148 lost
  SS Leinster 1918 sunk by UB-123, Kish Bank, 569 lost
  MV Princess Victoria 1953 foundered, 5m NE Mew Island, 133 lost. Fuller analysis.

Losses of over 40 people.
  Ferry 1664 foundered, Abermenai, 79 lost [not reliably documented]
  William 1696 aground, Dublin Bay, ~84 lost.
  Dublin 1758 foundered, off Galloway, ~60 lost.
  Fame 1785 aground, Red Wharf Bay, 42 lost
  Ferry 1785 aground, Abermenai, 54 lost
  Betty & Mary 1791 aground, off Liverpool, 47 lost
  Viceroy 1797 foundered, Irish Sea, 55 lost
  Victory 1803 aground, Hoyle Bank, 37-54 lost
  Fly 1817 aground, near Liverpool, 78 lost
  Earl Moira 1821 aground, near Liverpool, 52 lost
  Robert 1823 aground, Isle of Man, 40 lost
  Newry 1830 aground, Llŷn, 25-50 lost
  PS Lord Blayney 1833 aground, Hoyle Bank, 46 lost
  Lockwoods 1839 aground, near Liverpool, 53 lost
  PS William Huskisson 1840 foundered, Irish Sea, 47 lost
  PS Orion 1850   aground, Portpatrick, 54 lost
  Mobile 1852   aground Arklow Bank, 69 lost
  PS Queen Victoria 1853 aground, Howth Head, 59 lost
  PS Nimrod 1860 aground, Pembs, 45 lost
  PS Lelia 1865 foundered, Liverpool Bay, 47 lost (also here).
  SS Connemara 1916 collision, off Carlingford Lough, 90 lost
  HMS Champagne 1917 torpedo by U-96, off Calf of Man, 56 lost
  SS Apapa 1917 torpedo by U-96, off Anglesey, 77 lost
  HMAV Stephen Furness 1917 torpedo by UB-64, W of Isle of Man, 99 lost (101 in some accounts)
  SS Coningsberg 1917 torpedo by U-62, Irish Sea, 40 lost
  U-87 1917 rammed and depth charges, off Llŷn, 44 lost
  SS Alfred H Read 1917 mined Liverpool Bar, 41 lost
  HMS Cullist (Westphalia) 1918 Q-ship: torpedo by U-97, off Drogheda, 43 lost
  USS Lakemoor 1918 torpedo by UB-64 (or 73), off Corsewall Point, 44 lost
  HMS Thetis 1939 flooded, Liverpool Bay, 99 lost
  HMS Manners 1945(stern part) torpedo from U-1051, Irish Sea, 43 lost
  U-1051 1945 depth charges and rammed, Irish Sea, 47 lost
  U-1172 1945 depth charges, Irish Sea, 52 lost
  U-1302 1945 depth charges, Irish Sea, 48 lost
  U-246 1945 depth charges, Irish Sea, 48 lost, Video.
  U-242 1945 mined, Irish Sea, 44 lost