Left; domains within each family member are indicated; from N-terminal, DENN (purple), PH-G (red), Phosphatase (dark blue) or Inactive Phosphatase (blue), Coiled-coil (green), FYVE (grey), PH (orange) and PDZ (yellow). Phosphatase active MTMs are showed in bold. Right; predected domains by SMART (in green, Coiled-coil domain and in red, Low Complexity domain). Active members; MTM1, MTMR1-4, 6-8 and 14. Inactive members; MTMR5, 9-13 and 15.