Myotubularin (MTM) family is a large group of dual-phosphatases (DSP) formed for sixteen proteins. MTM family is dividided in two subgroups of active and inactive enzymes. All of them present a PHG domain (but MTMR14), a phosphatase domain (mutated in inactives) and a coiled-coil domain (but MTMR10). In addition, MTMR3 and MTMR4 posses a FYVE domain. Three of these are associated with genetic diseases; mutation in MTM1 leads to the Myotubular Myopathy, and mutation in MTMR2 and MTMR13 to the Charcot Marie Tooth disease.
Some interactions between the different members of both subgroups have been demonstrated; MTM1 interacts with MTMR12 (Nardurkar et al. and Mitchell et al.) and itself (Schaletzky et al.), MTMR2 with MTMR5 (Dixon et al.), MTMR12 (Nardurkar et al.), MTMR13 (Dixon et al.) and itself (Suter et al.), and MTMR9 with MTMR6 and MTMR7 (Majerous et al.).