MRes in Biological and Biomedical Sciences projects 25/26
If you’re looking to move into a career in science, whether in academia, industry, or biomedicine research, the Biological and Biomedical Sciences MRes will enable you to develop advanced knowledge, skills, and understanding of biological and biomedical sciences. A year-long research project, under the supervision of an expert tutor, forms the central part of the course. Selecting the right project is a key decision and we’ll help you choose a topic relevant to your interests and career plans.
| Project title | Supervisor | |
|---|---|---|
| Mechanisms controlling gene expression in hypoxia and inflammation. | Laboratory | Professor Sonia Rocha |
| Defining the roles of atypical phosphorylation in human cell signalling. | Laboratory | Professor Claire Eyers |
| Mass spectrometry-based analysis of protein post-translational modifications. | Laboratory | Professor Claire Eyers |
| RNA-binding as a new mechanism for coordinating kinase-based signalling. | Laboratory | Professor Patrick Eyers |
| Investigating the interactions between biomaterials for therapeutics and the immune system, for immune engineering. | Laboratory | Professor Neill Liptrott |
| Using AI for annotating the rice pan-genome. | Desk | Professor Andy Jones |
| Applying Deep Learning-based methods for protein structure prediction. | Desk | Professor Dan Rigden |
| Lysosomal damage from environmental microplastics. | Laboratory | Dr Laura Swan |
| Neglected signalling pathways in PTEN driven cancers- a new route to therapy? | Laboratory | Dr Laura Swan |
| Characterising the interaction of MTMR13 and Rab35: genes implicated in lysosomal function and the rare neuropathy, Charcot Marie Tooth Type 4. | Laboratory | Dr Laura Swan |
| A new enzymatic activity of a Parkinson’s related gene. | Laboratory | Dr Laura Swan |
| Elucidating the mito-pH physiology, using a new generation of Multiverse Genetically Encoded Fluorescent Probes. | Laboratory | Dr Massimiliano Stagi |
| Investigating the role of TP53 in the generation of short arm deletions of chromosome 17 in chronic lymphocytic leukaemia and other cancers. | Laboratory | Professor Joseph Slupsky |
| Investigating how the malignant cells of chronic lymphocytic leukaemia and other cancers adapt to loss of the short arm of chromosome 17. | Laboratory | Dr Mark Glenn |
| Blood biomarkers in newly diagnosed epilepsy. | Laboratory | Professor Simon Keller |
| Investigating the role of calcium-binding proteins in cardiovascular disease. | Laboratory | Dr Nordine Helassa |
| Why do cancers cells re-express meiotic SYCP1 protein? | Laboratory | Dr Urszula McClurg |
| Targeting meiotic proteins as cancer vaccines. | Laboratory | Dr Urszula McClurg |
| What drives re-expression of the latent toolbox of meiotic oncogenes in cancer? | Laboratory | Dr Urszula McClurg |
| Investigating the crosstalk between cellular metabolism and hypoxia signalling in cancer. | Laboratory | Dr Marco Sciacovelli |
| Application of structure-based drug discovery for treatment of Amyotrophic lateral sclerosis (ALS). | Laboratory | Dr Svetlana Antonyuk |
| Investigating the Role of Polarity Regulators in Pancreatic Ductal Adenocarcinoma (PDAC) Pathogenesis and Therapy. | Laboratory | Dr Pedro Perez-Mancera |
| Developing medical imaging technologies for diagnosis and treatment monitoring in cancer. | Laboratory | Professor Harish Poptani |
| Enhancing Metabolite Annotation for LC/MS Untargeted Metabolomics. | Desk | Dr Francesco Del Carratore |
| Development of Point-of-Care Devices for Therapeutic Drug Monitoring of Anti-Tuberculosis Drugs. | Laboratory | Dr Sanjiv Sharma |
| Development of Point-of-Care Devices for Therapeutic Drug Monitoring of Antivirals. | Laboratory | Dr Sanjiv Sharma |
| Wearable Devices for Therapeutic Drug Monitoring of Antibiotics Using Skin Interstitial Fluid. | Laboratory | Dr Sanjiv Sharma |
| The role of Cortical Microtubule Stabilising Complex (CMSC) proteins in extracellular matrix remodelling. | Laboratory | Dr Paul Atherton |
| Dietary polyphenols and glucuronides. | Laboratory | Dr Edwin Yates |
| Structural studies of pathogenic Nitric Oxide Reductase (NOR). | Laboratory | Professor Samar Hasnain |
| Analysing the microcephaly-related neurodevelopmental phenotype of Trappc9 mutations. | Laboratory | Dr Antonius Plagge |
| Functional and comparative genomics of the Crassulacean acid metabolism adaptation of photosynthetic carbon dioxide assimilation. | Laboratory | Dr James Hartwell |
| A 3D model to study the impact of antiepileptic drugs on placenta biology. | Laboratory | Dr Adeniyi Olagunju |
| Evaluation of Protective Actions of Novel Mitochondrial Targeted Compounds. | Desk | Dr David Criddle |
| Regulation of microtubule signalling complexes assembly through EB1 interactions. | Laboratory | Dr Igor Barsukov |
| Understanding the role of tensins in cell-matrix adhesion from biochemical data. | Laboratory | Dr Igor Barsukov |
| Biomolecular condensates as adhesion signalling hubs. | Laboratory | Dr Igor Barsukov |
| Migraine triggers: Identification of a novel gene that can cause brain bleeding. | Laboratory | Professor Ben Goult |
| Role of non-coding RNAs in cancer biology. | Laboratory | Professor Nagesh Kalakonda |
| Role and relevance of non-coding RNAs in cancer biology and therapeutics. | Laboratory | Professor Nagesh Kalakonda |
| Investigation of sever skin adverse drug reaction using cell and tissue culture models. | Laboratory | Dr Dan Carr |
| Investigation of immune heterogeneity in glioblastoma. | Laboratory | Rasheed Zakaria |
| Defining the imaging characteristics of an immune rich microenvironment in brain tumours. | Laboratory | Rasheed Zakaria |
| Understanding evolution and dissemination of bacterial plasmids encoding antimicrobial resistance. | Laboratory | Dr Yu Wan |
| Developing a methodological framework for surveillance of bacterial pathogens. | Laboratory | Dr Yu Wan |
| Application of the Extension Protein Engineering technique to engineer novel proteins and peptide targets. | Laboratory | Dr Elliott Stollar |
| Extracellular microvesicles and the metastatic niche in uveal melanoma. | Laboratory | Dr Helen Kalirai |
| Modulation of a blood-brain barrier model to enhance biological relevance. | Laboratory | Dr David Dickens |
| Integrating microglia into a blood-brain barrier model: enhancing physiological relevance and neuroimmune interactions. | Laboratory | Dr David Dickens |
| Mast cells: signalling in allergy and beyond. | Laboratory | Dr Nicola Darling |
| Characterising bacterial kinases as novel targets for antimicrobial therapies. | Laboratory | Dr Dominic Byrne |
| Identifying metabolic perturbations that drive kidney cancer. | Laboratory | Dr Paraskevi Kritsiligkou |
| Understanding the role of antioxidants in cellular protection. | Laboratory | Dr Paraskevi Kritsiligkou |
| Unravelling link between DNA and RNA Methylation and its clinical implications. | Laboratory | Dr Aditi Kanhere |
| The Role of DNA Methylation at the 3' UTR in Gene Regulation. | Laboratory | Dr Aditi Kanhere |
| Developing nanopore-based viral diagnostics. | Laboratory | Dr Edward Emmott |
| Understanding the immune microenvironment of uveal melanoma- towards improved therapeutic approaches. | Laboratory | Dr Joseph Sacco |
| Exploring pH changes using In Vivo Optical Imaging (IVIS Imaging System) in cardiovascular aging. | Laboratory | Dr Rebecca Burton |
| Receptor crosstalk mechanisms driving cancer and drug resistance. | Laboratory | Dr Mark Morgan |
| Scaling Down Human Tumoral Growth. | Laboratory | Dr Marisa Merino |
| Scaling By Death During Adult Organ Growth. | Laboratory | Dr Marisa Merino |
| Supramolecular Organisation of Morphogen Signal by Atomic Force Microscope. | Laboratory | Dr Marisa Merino |
| Investigating the role of the INO80 chromatin remodeler in transcription-replication conflicts in cancer: Mechanism and function in acute myeloid leukemia . | Laboratory | Dr Manolis Papamichos Chronakis |
| Genomic mechanisms of RNA surveillance and quality control | Laboratory | Dr Manolis Papamichos Chronakis |
| Investigating the role of the INO80 chromatin remodeler in transcription-replication conflicts in prostate cancer. | Laboratory | Dr Manolis Papamichos Chronakis |
| Synthetic lethality in chromatin assembly pathways. | Laboratory | Dr Colin Hammond |
| CENPA supply chain management and its influence on the epigenetic landscape. | Laboratory | Dr Colin Hammond |
| Investigating potential drivers of late-onset epilepsy associated with ageing. | Laboratory | Dr Natalia Sanchez Soriano |
| Genomic variation underpinning aging and neurodegenerative disease (Neurology). | Laboratory | Dr Ben Middlehurst |
| Bioengineering and Reprogramming of self-assembling protein organelles. | Laboratory | Professor Luning Liu |
| Understanding plasmid evolution through computational biology. | Desk | Dr James Hall |
| Investigating the biochemical changes in aortic pathologies. | Laboratory | Dr Jill Madine |
| Probing amyloid structural conformations: a combined computational and experimental approach. | Laboratory | Dr Jill Madine |
| Analysing migratory cell behaviour in a model of peritoneal scarring. | Laboratory | Dr Bettina Wilm |