Dr Stephen Aston MBChB BMedSc MRCP DTMH PhD

Research Overview

I undertake a portfolio of multidisciplinary and clinically-oriented research exploring strategies to mitigate the progression of antimicrobial resistance through optimised antibiotic prescribing in a variety of contexts - particularly in the management of suspected sepsis/serious bacterial infection and acute and chronic respiratory infection. My current projects relate to three broad avenues of work: (1) Examining the use of artificial-intelligence and machine-learning enabled analysis of routinely collected electronic health record data to support data-driven diagnosis of infection at both individual patient and health system levels; (2) Pragmatic clinical trials of interventions to minimise unnecessary antibiotic prescribing in suspected sepsis/serious bacterial infection; (3) Optimising selection, delivery and monitoring of complex antibiotic regimens in chronic respiratory infections, in particular non-tuberculous mycobacteria.