Professor Luciane Vieira de Mello (Lu Mello) publishing as Mello, LV
Deputy Dean, School of Life Sciences. PGT lead, Institute of Systems Molecular and Integrative Biology. Professor of Bioscience Education. School of Life Sciences
- +44 (0)151 795 4443
- Work email Luciane.Mello@liverpool.ac.uk
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Publications
Selected Publications
- 'Students-as-partners' scheme enhances postgraduate students' employability skills while addressing gaps in bioinformatics education. (Journal article - 2017)
- Students tell us what good written feedback looks like (Journal article - 2020)
- Supporting students during their undergraduate research projects using audio recordings (Journal article - 2018)
- Fostering postgraduate student engagement: online resources supporting self-directed learning in a diverse cohort (Journal article - 2016)
- A structured reflective process supports student awareness of employability skills development in a science placement module (Journal article - 2021)
- Developing transferable skills through embedding reflection in the science curriculum. (Journal article - 2021)
- Lecture capture affects student learning behaviour (Journal article - 2023)
- An exonuclease V homologue is expressed predominantly during early megasporogenesis in apomictic Brachiaria brizantha. (Journal article - 2023)
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2023
An exonuclease V homologue is expressed predominantly during early megasporogenesis in apomictic Brachiaria brizantha. (Journal article)
Dusi, D. M. A., Alves, E. R., Cabral, G. B., Mello, L. V., Rigden, D. J., Silveira, É. D., . . . Carneiro, V. T. C. (2023). An exonuclease V homologue is expressed predominantly during early megasporogenesis in apomictic Brachiaria brizantha.. Planta, 258(1), 5. doi:10.1007/s00425-023-04162-8Lecture capture affects student learning behaviour (Journal article)
Voelkel, S., Bates, A., Gleave, T., Larsen, C., Stollar, E. J., Wattret, G., & Mello, L. V. (2023). Lecture capture affects student learning behaviour. FEBS OPEN BIO. doi:10.1002/2211-5463.135482022
A special issue of Essays in Biochemistry on current educational developments in molecular bioscience. (Journal article)
Mello, L. V., & Watson, H. R. (2022). A special issue of Essays in Biochemistry on current educational developments in molecular bioscience.. Essays in biochemistry, 66(1), 1-3. doi:10.1042/ebc202200322021
Developing transferable skills through embedding reflection in the science curriculum. (Journal article)
Mello, L. V., & Wattret, G. (2021). Developing transferable skills through embedding reflection in the science curriculum.. Biophysical reviews, 13(6), 897-903. doi:10.1007/s12551-021-00852-3Evolving Molecular Bioscience Education 2021 (Journal article)
Eskild, W., May, G., Michelangeli, F., Minchin, S., Roberts, M., Sağın, F., . . . Watson, H. (2021). Evolving Molecular Bioscience Education 2021. The Biochemist, 43(4), 49. doi:10.1042/bio_2021_160A structured reflective process supports student awareness of employability skills development in a science placement module (Journal article)
Mello, L. V., Varga-Atkins, T., & Edwards, S. W. (2021). A structured reflective process supports student awareness of employability skills development in a science placement module. FEBS OPEN BIO, 11(6), 1524-1536. doi:10.1002/2211-5463.131582020
Students tell us what good written feedback looks like (Journal article)
Voelkel, S., Varga-Atkins, T., & Mello, L. V. (2020). Students tell us what good written feedback looks like. FEBS Open Bio, 10(5), 692-706. doi:10.1002/2211-5463.128412018
Supporting students during their undergraduate research projects using audio recordings (Journal article)
Voelkel, S., Mello, L. V., & Varga-Atkins, T. (2018). Supporting students during their undergraduate research projects using audio recordings. INNOVATIONS IN EDUCATION AND TEACHING INTERNATIONAL, 55(4), 433-440. doi:10.1080/14703297.2016.12632332017
Publishing on Education (Presentation material)
Mello, L. V. (2017). Publishing on Education. Weizmann Institute of Sciences, Rehovot, Israel.FEBS Open Bio - Education Session (Edited special journal issue)
Mello, L. V., & Herráez, A. (Eds.) (n.d.). FEBS Open Bio - Education Session (Vol. 1).How undergraduate and postgraduate science students perceive self- and peer-assessed group work (Journal article)
Mello,, L. V., & Voelkel, S. (2017). How undergraduate and postgraduate science students perceive self- and peer-assessed group work. Practice and Evidence of the Scholarship of Teaching and Learning in Higher Education.'Students-as-partners' scheme enhances postgraduate students' employability skills while addressing gaps in bioinformatics education. (Journal article)
Mello, L. V., Tregilgas, L., Cowley, G., Gupta, A., Makki, F., Jhutty, A., & Shanmugasundram, A. (2017). 'Students-as-partners' scheme enhances postgraduate students' employability skills while addressing gaps in bioinformatics education.. Higher education pedagogies, 2(1), 43-57. doi:10.1080/23752696.2017.13392872016
Fostering postgraduate student engagement: online resources supporting self-directed learning in a diverse cohort (Journal article)
Mello, L. V. (2016). Fostering postgraduate student engagement: online resources supporting self-directed learning in a diverse cohort. Research in Learning Technology, 24(1), 29366. doi:10.3402/rlt.v24.293662015
Reflective research project assessment using PebblePad (Conference Paper)
Mello, L. V., & Vieira De Mello Rigden, L. (2015). Reflective research project assessment using PebblePad. In Recognising and Sharing Teaching Excellence. XJTLU, Suzhou, China.Reflective research project assessment using PebblePad (Presentation material)
Mello, L. V., Bates, A., & Alston, P. (2015). Reflective research project assessment using PebblePad. Edge Hill University, Ormskirk, Lancashire.2014
Audio Feedback – Better Feedback? (Journal article)
Voelkel, S., & Mello, L. V. (2014). Audio Feedback – Better Feedback?. Bioscience Education, 22(1), 16-30. doi:10.11120/beej.2014.00022Fostering postgraduate student engagement in bioinformatics at a UK university (Thesis / Dissertation)
Mello, L. V. (2014, March 10). Fostering postgraduate student engagement in bioinformatics at a UK university.Exploiting inter-cohort student partnerships for learning and teaching (Conference Paper)
Mello, L. V. (2014). Exploiting inter-cohort student partnerships for learning and teaching. In HEA (Ed.), Crowdsourcing in HE. How to harness the enthusiasm of our students in their own learning (pp. 1). Bristol: HEA. Retrieved from http://www.heacademy.ac.uk/events/detail/2014/28-Feb-STEM-Crowdsourcing-BristolStaff-student partnership and peer facilitation fostering student engagement and teaching skills development (Conference Paper)
Mello, L. V., & al., E. (2014). Staff-student partnership and peer facilitation fostering student engagement and teaching skills development. In HEA (Ed.), HEA STEM conference 2014 (pp. 1). Edinburgh, UK: HEA.Student-centred supervision of undergraduate dissertations (Conference Paper)
Voelkel, S., & Mello, L. V. (2014). Student-centred supervision of undergraduate dissertations. In HEA (Ed.), HEA STEM conference 2014 (pp. 1). Edinburgh, UK: HEA.2013
Audio feedback - better feedback? (Conference Paper)
Voelkel, S., & Mello, L. V. (2013). Audio feedback - better feedback?. In HEA STEM: Annual Learning and Teaching Conference 2013: Where practice and pedagogy meet (pp. 2). Birmingham: HEA.Innovations in teaching of bioinformatics to a diverse group of postgraduate students (Conference Paper)
Mello, L. V. (2013). Innovations in teaching of bioinformatics to a diverse group of postgraduate students. In Learning and Teaching Conference (pp. 10). Liverpool: University of Liverpool.New roles for well-known tools: setting the scene (Conference Paper)
Vieira De Mello Rigden, L. (2013). New roles for well-known tools: setting the scene. In Learner analytics: a method for learner experience researchers - or not? (pp. 1). Liverpool: ELESIG.Student diversity and changes in teaching practices (Conference Paper)
Mello, L. V., & Voelkel, S. (2013). Student diversity and changes in teaching practices. In HEA STEM: Annual Learning and Teaching Conference 2013: Where practice and pedagogy meet (pp. 1). Birmingham: HEA.2012
A new family of bacterial DNA repair proteins annotated by the integration of non-homology, distant homology and structural bioinformatic methods (Journal article)
Mello, L. V., & Rigden, D. J. (2012). A new family of bacterial DNA repair proteins annotated by the integration of non-homology, distant homology and structural bioinformatic methods. FEBS LETTERS, 586(21), 3908-3913. doi:10.1016/j.febslet.2012.09.023Changes in teaching practice for dealing with student diversity at Master Level. (Conference Paper)
Mello, L. V. (2012). Changes in teaching practice for dealing with student diversity at Master Level.. In HEA Workshop and Seminar Series 2012 (pp. 1). Liverpool: HEA. Retrieved from http://www.heacademy.ac.uk/Internationalisation and student diversity: overlapping challenges (Conference Paper)
Mello, L. V. (2012). Internationalisation and student diversity: overlapping challenges. In University of Liverpool Learning and Teaching Conference (pp. 30). Liverpool: University of Liverpool.The use of technology promoting student engagement and self-directed learning in a PGT cohort. (Conference Paper)
Mello, L. V. (2012). The use of technology promoting student engagement and self-directed learning in a PGT cohort.. In Society of Experimental Biology Education and Public Affairs Section Symposium (pp. 20). London: SEB.Using pre-class online tests in combination with podcasts to address students' diversity (Conference Paper)
Mello, L. V. (2012). Using pre-class online tests in combination with podcasts to address students' diversity. In HEA Workshop and Seminar Series 2012 (pp. 1). Liverpool: HEA. Retrieved from http://www.heacademy.ac.uk/2011
The transcriptome of the novel dinoflagellate Oxyrrhis marina (Alveolata: Dinophyceae): response to salinity examined by 454 sequencing. (Journal article)
Lowe, C. D., Mello, L. V., Samatar, N., Martin, L. E., Montagnes, D. J. S., & Watts, P. C. (2011). The transcriptome of the novel dinoflagellate Oxyrrhis marina (Alveolata: Dinophyceae): response to salinity examined by 454 sequencing.. BMC genomics, 12, 519. doi:10.1186/1471-2164-12-519Idenification of genes responding to nematode infection in red grouse (Journal article)
Webster, L. M. I., Mello, L. V., Mougeot, F., Martinez-Padilla, J., Paterson, S., & Piertney, S. B. (2011). Idenification of genes responding to nematode infection in red grouse. Mol Ecol Resour., 11(2), 305-313. doi:10.1111/j.1755-0998The use of technology promoting self-directed learning in a PGT cohort: a pilot study (Conference Paper)
Mello, L. V. (2011). The use of technology promoting self-directed learning in a PGT cohort: a pilot study. In University of Liverpool Learning and Teaching Conference (pp. Session 13). Liverpool: The University of Liverpool.2010
Mining metagenomic data for novel domains: BACON, a new carbohydrate-binding module (Journal article)
Mello, L. V., Chen, X., & Rigden, D. J. (2010). Mining metagenomic data for novel domains: BACON, a new carbohydrate-binding module. FEBS LETTERS, 584(11), 2421-2426. doi:10.1016/j.febslet.2010.04.045Getting postgraduate students to think outside their discipline (Conference Paper)
Mello, L. V. (2010). Getting postgraduate students to think outside their discipline. In University of Liverpool Learning and Teaching Conference (pp. Session 5). Liverpool: University of Liverpool.Response of the Strongyloides ratti transcriptome to host immunological environment (Journal article)
O'Meara, H., Barber, R., Mello, L. V., Sangaralingam, A., Viney, M. E., & Paterson, S. (2010). Response of the Strongyloides ratti transcriptome to host immunological environment. J Parasitol., 40(14), 1609-1617.2009
Identification of novel aspartic proteases from <i>Strongyloides ratti</i> and characterisation of their evolutionary relationships, stage-specific expression and molecular structure (Journal article)
Mello, L. V., O'Meara, H., Rigden, D. J., & Paterson, S. (2009). Identification of novel aspartic proteases from <i>Strongyloides ratti</i> and characterisation of their evolutionary relationships, stage-specific expression and molecular structure. BMC GENOMICS, 10. doi:10.1186/1471-2164-10-611Molecular Dynamics and Electrochemical Investigations of a pH-Responsive Peptide Monolayer (Journal article)
Doneux, T., Bouffier, L., Mello, L. V., Rigden, D. J., Kejnovska, I., Fernig, D. G., . . . Nichols, R. J. (2009). Molecular Dynamics and Electrochemical Investigations of a pH-Responsive Peptide Monolayer. JOURNAL OF PHYSICAL CHEMISTRY C, 113(16), 6792-6799. doi:10.1021/jp810859kRegional variation in parvalbumin isoform expression correlates with muscle performance in common carp (<i>Cyprinus carpio</i>) (Journal article)
Brownridge, P., de Mello, L. V., Peters, M., McLean, L., Claydon, A., Cossins, A. R., . . . Young, I. S. (2009). Regional variation in parvalbumin isoform expression correlates with muscle performance in common carp (<i>Cyprinus carpio</i>). JOURNAL OF EXPERIMENTAL BIOLOGY, 212(2), 184-193. doi:10.1242/jeb.021857ExprAlign - the identification of ESTs in non-model species by alignment of cDNA microarray expression profiles (Journal article)
Li, W., Gracey, A. Y., Mello, L. V., Brass, A., & Cossins, A. R. (2009). ExprAlign - the identification of ESTs in non-model species by alignment of cDNA microarray expression profiles. BMC Genomics, 10, 560.2008
Microarray analysis of gender- and parasite-specific gene transcription in <i>Strongyloides ratti</i> (Journal article)
Evans, H., Mello, L. V., Fang, Y., Wit, E., Thompson, F. J., Viney, M. E., & Paterson, S. (2008). Microarray analysis of gender- and parasite-specific gene transcription in <i>Strongyloides ratti</i>. INTERNATIONAL JOURNAL FOR PARASITOLOGY, 38(11), 1329-1341. doi:10.1016/j.ijpara.2008.02.004S-nitrosylation of syntaxin 1 at Cys<SUP>145</SUP> is a regulatory switch controlling Munc18-1 binding (Journal article)
Palmer, Z. J., Duncan, R. R., Johnson, J. R., Lian, L. -Y., Mello, L. V., Booth, D., . . . Morgan, A. (2008). S-nitrosylation of syntaxin 1 at Cys<SUP>145</SUP> is a regulatory switch controlling Munc18-1 binding. BIOCHEMICAL JOURNAL, 413, 479-491. doi:10.1042/BJ20080069ribB and ribBA genes from Acidithiobacillus ferrooxidans: expression levels under different growth conditions and phylogenetic analysis. (Journal article)
Knegt, F. H. P., Mello, L. V., Reis, F. C., Santos, M. T., Vicentini, R., Ferraz, L. F. C., & Ottoboni, L. M. M. (2008). ribB and ribBA genes from Acidithiobacillus ferrooxidans: expression levels under different growth conditions and phylogenetic analysis.. Research in microbiology, 159(6), 423-431. doi:10.1016/j.resmic.2008.04.0022007
Structural flexibility in <i>Trypanosoma brucei</i> enolase revealed by X-ray crystallography and molecular dynamics (Journal article)
Navarro, M. V. D. A. S., Dias, S. M. G., Mello, L. V., Giotto, M. T. D. S., Gavalda, S., Blonski, C., . . . Rigden, D. J. (2007). Structural flexibility in <i>Trypanosoma brucei</i> enolase revealed by X-ray crystallography and molecular dynamics. FEBS JOURNAL, 274(19), 5077-5089. doi:10.1111/j.1742-4658.2007.06027.xStructure and molecular mechanism of Bacillus anthracis cofactor-independent phosphoglycerate mutase: a crucial enzyme for spores and growing cells of Bacillus species. (Journal article)
Nukui, M., Mello, L. V., Littlejohn, J. E., Setlow, B., Setlow, P., Kim, K., . . . Jedrzejas, M. J. (2007). Structure and molecular mechanism of Bacillus anthracis cofactor-independent phosphoglycerate mutase: a crucial enzyme for spores and growing cells of Bacillus species.. Biophysical journal, 92(3), 977-988. doi:10.1529/biophysj.106.0938722006
Hypoxia-inducible myoglobin expression in nonmuscle tissues (Journal article)
Fraser, J., de Mello, L. V., Ward, D., Rees, H. H., Williams, D. R., Fang, Y. C., . . . Cossins, A. R. (2006). Hypoxia-inducible myoglobin expression in nonmuscle tissues. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(8), 2977-2981. doi:10.1073/pnas.0508270103Structure and enzyme properties of Zabrotes subfasciatus alpha-amylase. (Journal article)
Pelegrini, P. B., Murad, A. M., Grossi-de-Sá, M. F., Mello, L. V., Romeiro, L. A. S., Noronha, E. F., . . . Franco, O. L. (2006). Structure and enzyme properties of Zabrotes subfasciatus alpha-amylase.. Archives of insect biochemistry and physiology, 61(2), 77-86. doi:10.1002/arch.200992005
Monomorphic subtelomeric DNA in the filamentous fungus, <i>Metarhizium anisopliae</i>,contains a RecQ helicase-like gene (Journal article)
Inglis, P. W., Rigden, D. J., Mello, L. V., Louis, E. J., & Valadares-Inglis, M. C. (2005). Monomorphic subtelomeric DNA in the filamentous fungus, <i>Metarhizium anisopliae</i>,contains a RecQ helicase-like gene. MOLECULAR GENETICS AND GENOMICS, 274(1), 79-90. doi:10.1007/s00438-005-1154-5Nucleotide sequence and phylogenetic analyses of the DNA polymerase gene of <i>Anticarsia gemmatalis</i> nucleopolyhedrovirus (Journal article)
Dalmolin, C. C., da Silva, F. R., Mello, L. V., Rigden, D. J., & Castro, M. E. B. (2005). Nucleotide sequence and phylogenetic analyses of the DNA polymerase gene of <i>Anticarsia gemmatalis</i> nucleopolyhedrovirus. VIRUS RESEARCH, 110(1-2), 99-109. doi:10.1016/j.virusres.2005.01.0102004
The PA14 domain, a conserved all-beta domain in bacterial toxins, carbohydrate-active enzymes and adhesins. (Journal article)
Rigden, D. J., Mello, L. V., & Galperin, M. Y. (2004). The PA14 domain, a conserved all-beta domain in bacterial toxins, carbohydrate-active enzymes and adhesins.. Trends Biochem Sci. J., 29(7), 335-339.2003
Identification of differentially expressed cDNA sequences in ovaries of sexual and apomictic plants of <i>Brachiaria brizantha</i> (Journal article)
Rodrigues, J. C. M., Cabral, G. B., Dusi, D. M. A., de Mello, L. V., Rigden, D. J., & Carneiro, V. T. C. (2003). Identification of differentially expressed cDNA sequences in ovaries of sexual and apomictic plants of <i>Brachiaria brizantha</i>. PLANT MOLECULAR BIOLOGY, 53(6), 745-757. doi:10.1023/B:PLAN.0000023664.21910.bdUse of phage display to select novel cystatins specific for <i>Acanthoscelides obtectus</i> cysteine proteinases (Journal article)
Melo, F. R., Mello, M. O., Franco, O. L., Rigden, D. J., Mello, L. V., Genú, A. M., . . . Grossi-de-Sá, M. F. (2003). Use of phage display to select novel cystatins specific for <i>Acanthoscelides obtectus</i> cysteine proteinases. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1651(1-2), 146-152. doi:10.1016/S1570-9639(03)00264-4Identification and analysis of catalytic TIM barrel domains in seven further glycoside hydrolase families (Journal article)
Rigden, D. J., Jedrzejas, M. J., & de Mello, L. V. (2003). Identification and analysis of catalytic TIM barrel domains in seven further glycoside hydrolase families. FEBS LETTERS, 544(1-3), 103-111. doi:10.1016/s0014-5793(03)00481-2Insights into the catalytic mechanism of cofactor-independent phosphoglycerate mutase from X-ray crystallography, simulated dynamics and molecular modeling (Journal article)
Rigden, D. J., Lamani, E., Mello, L. V., Littlejohn, J. E., & Jedrzejas, M. J. (2003). Insights into the catalytic mechanism of cofactor-independent phosphoglycerate mutase from X-ray crystallography, simulated dynamics and molecular modeling. JOURNAL OF MOLECULAR BIOLOGY, 328(4), 909-920. doi:10.1016/S0022-2836(03)00350-4Molecular cloning of α-amylases from cotton boll weevil, <i>Anthonomus grandis</i> and structural relations to plant inhibitors:: An approach to insect resistance (Journal article)
Oliveira-Neto, O. B., Batista, J. A. N., Rigden, D. J., Franco, O. L., Falcao, R., Fragoso, R. R., . . . Grossi-de-Sá, M. F. (2003). Molecular cloning of α-amylases from cotton boll weevil, <i>Anthonomus grandis</i> and structural relations to plant inhibitors:: An approach to insect resistance. JOURNAL OF PROTEIN CHEMISTRY, 22(1), 77-87. doi:10.1023/A:10230240126572002
Overlapping binding sites for trypsin and papain on a Kunitz-type proteinase inhibitor from <i>Prosopis juliflora</i> (Journal article)
Franco, O. L., de Sá, M. F. G., Sales, M. P., Mello, L. V., Oliveira, A. S., & Rigden, D. J. (2002). Overlapping binding sites for trypsin and papain on a Kunitz-type proteinase inhibitor from <i>Prosopis juliflora</i>. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 49(3), 335-341. doi:10.1002/prot.10228Structure and flexibility of Streptococcus agalactiae hyaluronate lyase complex with its substrate. Insights into the mechanism of processive degradation of hyaluronan. (Journal article)
Mello, L. V., De Groot, B. L., Li, S., & Jedrzejas, M. J. (2002). Structure and flexibility of Streptococcus agalactiae hyaluronate lyase complex with its substrate. Insights into the mechanism of processive degradation of hyaluronan.. The Journal of biological chemistry, 277(39), 36678-36688. doi:10.1074/jbc.m205140200Mechanism of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase. Structures of complexes with the substrate. (Journal article)
Jedrzejas, M. J., Mello, L. V., de Groot, B. L., & Li, S. (2002). Mechanism of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase. Structures of complexes with the substrate.. The Journal of biological chemistry, 277(31), 28287-28297. doi:10.1074/jbc.m112009200Inhibition of trypsin by cowpea thionin:: Characterization, molecular modeling, and docking (Journal article)
Melo, F. R., Rigden, D. J., Franco, O. L., Mello, L. V., Ary, M. B., de Sá, M. F. G., & Bloch, C. (2002). Inhibition of trypsin by cowpea thionin:: Characterization, molecular modeling, and docking. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 48(2), 311-319. doi:10.1002/prot.10142Biochemical characteristics of guanine nucleotide binding protein alpha-subunit recombinant protein and three mutants: investigation of a domain motion involved in GDP-GTP exchange. (Journal article)
Mello, L. V., Millner, P. A., & Findlay, J. B. (2002). Biochemical characteristics of guanine nucleotide binding protein alpha-subunit recombinant protein and three mutants: investigation of a domain motion involved in GDP-GTP exchange.. J Protein Chem, 21(1), 29-34.Structure and mechanism of action of a cofactor-dependent phosphoglycerate mutase homolog from Bacillus stearothermophilus with broad specificity phosphatase activity. (Journal article)
Rigden, D. J., Mello, L. V., Setlow, P., & Jedrzejas, M. J. (2002). Structure and mechanism of action of a cofactor-dependent phosphoglycerate mutase homolog from Bacillus stearothermophilus with broad specificity phosphatase activity.. J Mol Biol, 358, 101-110.2001
Functional and structural roles of the glutathione-binding residues in maize (Zea mays) glutathione S-transferase I (Journal article)
LABROU, N. E., MELLO, L. V., & CLONIS, Y. D. (2001). Functional and structural roles of the glutathione-binding residues in maize (Zea mays) glutathione S-transferase I. Biochemical Journal, 358(1), 101-110. doi:10.1042/bj35801012000
Structural modeling of a plant disease resistance gene product domain (Journal article)
Rigden, D. J., Mello, L. V., & Bertioli, D. J. (2000). Structural modeling of a plant disease resistance gene product domain. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 41(1), 133-143. doi:3.0.CO;2-M">10.1002/1097-0134(20001001)41:1<133::AID-PROT150>3.0.CO;2-MDOI: 10.1002/1097-0134(20001001)41:1<133::AID-PROT150>3.0.CO;2-M