Dr Lawrence Barrera Briceno BSc (Hons), MSc, PhD, AFHE, MRSB

Research Overview

I specialise in studying the pancreatic tumour microenvironment and have a keen interest in exploring the role of Nrf2 transcription factor-regulated genes in chemotherapy resistance mechanisms. My research involves leveraging primary cells and various cell model systems such as co-culture, 3D spheroids and organoids to unravel the intricate communication between cancer cells and cancer-associated fibroblasts. I investigate their complex interactions with surrounding cells and molecules to better understand their impact on DNA methylation marks and microRNAs, all in pursuit of unravelling their implication in cancer progression.

My current interest is focused on harnessing single-cell RNA sequencing technologies to dissect the heterogeneity within the tumour microenvironment, aiming to identify vulnerable cell populations and pave the way for the development of innovative treatments. I collaborate with Prof Eithne Costello and Dr Pedro Perez-Mancera within the Institute.