2024
Machine-Learning Assisted Screening of Correlated Covariates: Application to Clinical Data of Desipramine. (Journal article)
Asiimwe, I. G., S'fiso Ndzamba, B., Mouksassi, S., Pillai, G. C., Lombard, A., & Lang, J. (2024). Machine-Learning Assisted Screening of Correlated Covariates: Application to Clinical Data of Desipramine.. The AAPS journal, 26(4), 63. doi:10.1208/s12248-024-00934-6DOI: 10.1208/s12248-024-00934-6
Asiimwe, I. G., & Pirmohamed, M. (2024). CYP3A4*22 and bleeding risk in ticagrelor users.. Basic & clinical pharmacology & toxicology, 134(3), 311-314. doi:10.1111/bcpt.13977DOI: 10.1111/bcpt.13977
Asiimwe, I. G., Walker, L., Sofat, R., Jorgensen, A. L., Pirmohamed, M., & Multimorbidity Mechanism and Therapeutic Research Collaborative (MMTRC). (2024). Genetic Determinants of Thiazide-Induced Hyperuricemia, Hyperglycemia, and Urinary Electrolyte Disturbances - A Genome-Wide Evaluation of the UK Biobank.. Clinical pharmacology and therapeutics. doi:10.1002/cpt.3229DOI: 10.1002/cpt.3229
Costigan, D., Fenn, J., Yen, S., Ilott, N., Bullers, S., Hale, J., . . . Thornton, E. E. (2024). A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies.. Mucosal immunology, 17(1), 111-123. doi:10.1016/j.mucimm.2023.11.005DOI: 10.1016/j.mucimm.2023.11.005
Devine, K., Russell, C. D., Blanco, G. R., Walker, B. R., Homer, N. Z. M., Denham, S. G., . . . ISARIC4C Investigators and PHOSP-COVID Study Collaborative Group. (2024). Plasma steroid concentrations reflect acute disease severity and normalise during recovery in people hospitalised with COVID-19.. Clinical endocrinology. doi:10.1111/cen.15012DOI: 10.1111/cen.15012
Lord, J. M., Veenith, T., Sullivan, J., Sharma-Oates, A., Richter, A. G., Greening, N. J., . . . ISARIC4C investigators. (2024). Accelarated immune ageing is associated with COVID-19 disease severity.. Immunity & ageing : I & A, 21(1), 6. doi:10.1186/s12979-023-00406-zDOI: 10.1186/s12979-023-00406-z
2023
Sidhu, J. K., Siggins, M. K., Liew, F., Russell, C. D., Uruchurtu, A. S. S., Davis, C., . . . ISARIC4C investigators. (2023). Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19.. The Journal of infectious diseases, jiad590. doi:10.1093/infdis/jiad590DOI: 10.1093/infdis/jiad590
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2023). Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 14(1), 8487. doi:10.1038/s41467-023-42320-4DOI: 10.1038/s41467-023-42320-4
Alrezaihi, A., Penrice-Randal, R., Dong, X., Prince, T., Randle, N., Semple, M. G., . . . Hiscox, J. A. (2023). Enrichment of SARS-CoV-2 sequence from nasopharyngeal swabs whilst identifying the nasal microbiome. Journal of Clinical Virology, 105620. doi:10.1016/j.jcv.2023.105620DOI: 10.1016/j.jcv.2023.105620
Swets, M. C., Kerr, S., Scott-Brown, J., Brown, A. B., Gupta, R., Millar, J. E., . . . Baillie, J. K. (2023). Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity.. Nature communications, 14(1), 7374. doi:10.1038/s41467-023-42205-6DOI: 10.1038/s41467-023-42205-6
Zhu, Y., Almeida, F. J., Baillie, J. K., Bowen, A. C., Britton, P. N., Brizuela, M. E., . . . Short, K. R. (2023). International Pediatric COVID-19 Severity Over the Course of the Pandemic. JAMA PEDIATRICS. doi:10.1001/jamapediatrics.2023.3117DOI: 10.1001/jamapediatrics.2023.3117
Yang, H., Sun, H., Brackenridge, S., Zhuang, X., Wing, P. A. C., Quastel, M., . . . McMichael, A. J. (2023). HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation. SCIENCE IMMUNOLOGY, 8(84). doi:10.1126/sciimmunol.abl8881DOI: 10.1126/sciimmunol.abl8881
Pauley, E., Drake, T. M., Griffith, D. M., Sigfrid, L., Lone, N. I., Harrison, E. M., . . . Docherty, A. B. (2023). Recovery from Covid-19 critical illness: A secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial. JOURNAL OF THE INTENSIVE CARE SOCIETY, 24(2), 162-169. doi:10.1177/17511437211052226DOI: 10.1177/17511437211052226
Ho, A., Orton, R., Tayler, R., Asamaphan, P., Herder, V., Davis, C., . . . Thomson, E. C. (2023). Adeno-associated virus 2 infection in children with non-A-E hepatitis.. Nature. doi:10.1038/s41586-023-05948-2DOI: 10.1038/s41586-023-05948-2
Goldswain, H., Dong, X., Penrice-Randal, R., Alruwaili, M., Shawli, G. T., Prince, T., . . . Hiscox, J. A. (2023). The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.. Genome biology, 24(1), 47. doi:10.1186/s13059-023-02881-5DOI: 10.1186/s13059-023-02881-5
Jorgensen, A. L., Orrell, C., Waitt, C., Toh, C. -H., Sekaggya-Wiltshire, C., Hughes, D. A., . . . Pirmohamed, M. (2023). A "Bundle of Care" to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study. JMIR RESEARCH PROTOCOLS, 12. doi:10.2196/46710DOI: 10.2196/46710
A “Bundle of Care” to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study (Preprint) (Preprint)
DOI: 10.2196/preprints.46710
Keogh, R. H., Diaz-Ordaz, K., Jewell, N. P., Semple, M. G., de Wreede, L. C., & Putter, H. (2023). Estimating distribution of length of stay in a multi-state model conditional on the pathway, with an application to patients hospitalised with Covid-19. Lifetime Data Analysis. doi:10.1007/s10985-022-09586-0DOI: 10.1007/s10985-022-09586-0
Turtle, L., Thorpe, M., Drake, T. M., Swets, M., Palmieri, C., Russell, C. D., . . . Docherty, A. B. (2023). Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study.. PLoS medicine, 20(1), e1004086. doi:10.1371/journal.pmed.1004086DOI: 10.1371/journal.pmed.1004086
A genome-wide association study of plasma concentrations of warfarin enantiomers and metabolites in sub-Saharan Black-African patients (Conference Paper)
Asiimwe, I., Zhang, E., Jorgensen, A., & Pirmohamed, M. (2023). A genome-wide association study of plasma concentrations of warfarin enantiomers and metabolites in sub-Saharan Black-African patients. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 89 (pp. 1248-1249). Retrieved from https://www.webofscience.com/
A genome-wide association study of stable warfarin dose in sub-Saharan African patients (Conference Paper)
Asiimwe, I., Zhang, E., Jorgensen, A., & Pirmohamed, M. (2023). A genome-wide association study of stable warfarin dose in sub-Saharan African patients. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 89 (pp. 1249). Retrieved from https://www.webofscience.com/
Kuan, V., Denaxas, S., Patalay, P., Nitsch, D., Mathur, R., Gonzalez-Izquierdo, A., . . . MMTRC. (2023). Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study. LANCET DIGITAL HEALTH, 5(1), E16-E27. doi:10.1016/S2589-7500(22)00187-XDOI: 10.1016/S2589-7500(22)00187-X
Parker, E., Thomas, J., Roper, K. J., Ijaz, S., Edwards, T., Marchesin, F., . . . Pollakis, G. (2023). SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study. FRONTIERS IN IMMUNOLOGY, 14. doi:10.3389/fimmu.2023.1146702DOI: 10.3389/fimmu.2023.1146702
Liew, F., Talwar, S., Cross, A., Willett, B. J., Scott, S., Logan, N., . . . Openshaw, P. J. M. (2023). SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. EBIOMEDICINE, 87. doi:10.1016/j.ebiom.2022.104402DOI: 10.1016/j.ebiom.2022.104402
2022
Asiimwe, I. G., & Pirmohamed, M. (2022). Drug-Drug-Gene Interactions in Cardiovascular Medicine. PHARMACOGENOMICS & PERSONALIZED MEDICINE, 15, 879-911. doi:10.2147/PGPM.S338601DOI: 10.2147/PGPM.S338601
Grundmann, A., Wu, C. -H., Hardwick, M., Baillie, J. K., Openshaw, P. J. M., Semple, M. G., . . . ISARIC4C investigators. (2022). Fewer COVID-19 Neurological Complications with Dexamethasone and Remdesivir.. Annals of neurology. doi:10.1002/ana.26536DOI: 10.1002/ana.26536
Vink, E., Davis, C., MacLean, A., Pascall, D., McDonald, S. E., Gunson, R., . . . Ho, A. (2022). Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. OPEN FORUM INFECTIOUS DISEASES, 9(11). doi:10.1093/ofid/ofac531DOI: 10.1093/ofid/ofac531
Siggins, M. K., Davies, K., Fellows, R., Thwaites, R. S., Baillie, J. K., Semple, M. G., . . . ISARIC4C Investigators. (2022). Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.. Immunology. doi:10.1111/imm.13585DOI: 10.1111/imm.13585
Asiimwe, I. G., Blockman, M., Cohen, K., Cupido, C., Hutchinson, C., Jacobson, B., . . . Pirmohamed, M. (2022). A genome-wide association study of plasma concentrations of warfarin enantiomers and metabolites in sub-Saharan black-African patients.. Frontiers in pharmacology, 13, 967082. doi:10.3389/fphar.2022.967082DOI: 10.3389/fphar.2022.967082
Keeling, M. J., Dyson, L., Guyver-Fletcher, G., Holmes, A., Semple, M. G., Tildesley, M. J., & Hill, E. M. (2022). Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number. STATISTICAL METHODS IN MEDICAL RESEARCH, 31(9), 1716-1737. doi:10.1177/09622802211070257DOI: 10.1177/09622802211070257
Asiimwe, I. G., Pushpakom, S. P., Turner, R. M., Kolamunnage-Dona, R., Jorgensen, A. L., & Pirmohamed, M. (2022). Cardiovascular drugs and COVID-19 clinical outcomes: a systematic review and meta-analysis of randomized controlled trials. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 88(8), 3577-3599. doi:10.1111/bcp.15331DOI: 10.1111/bcp.15331
Ijaz, S., Dicks, S., Jegatheesan, K., Parker, E., Katsanovskaja, K., Vink, E., . . . Tedder, R. S. (2022). Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients. JOURNAL OF INFECTION, 85(2), 152-160. doi:10.1016/j.jinf.2022.05.033DOI: 10.1016/j.jinf.2022.05.033
Norris, T., Razieh, C., Zaccardi, F., Yates, T., Islam, N., Gillies, C. L., . . . Khunti, K. (2022). Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19. HEART, 108(15), 1200-1208. doi:10.1136/heartjnl-2021-320047DOI: 10.1136/heartjnl-2021-320047
McNaughton, A. L., Paton, R. S., Edmans, M., Youngs, J., Wellens, J., Phalora, P., . . . Thompson, C. P. (2022). Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses. JCI INSIGHT, 7(13). doi:10.1172/jci.insight.156372DOI: 10.1172/jci.insight.156372
Tuekprakhon, A., Nutalai, R., Dijokaite-Guraliuc, A., Zhou, D., Ginn, H. M., Selvaraj, M., . . . Screaton, G. R. (2022). Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum. CELL, 185(14), 2422-+. doi:10.1016/j.cell.2022.06.005DOI: 10.1016/j.cell.2022.06.005
Knight, G. M., Thi, M. P., Stimson, J., Funk, S., Jafari, Y., Pople, D., . . . Robotham, J. V. (2022). The contribution of hospital-acquired infections to the COVID-19 epidemic in England in the first half of 2020. BMC INFECTIOUS DISEASES, 22(1). doi:10.1186/s12879-022-07490-4DOI: 10.1186/s12879-022-07490-4
Nutalai, R., Zhou, D., Tuekprakhon, A., Ginn, H. M., Supasa, P., Liu, C., . . . Screaton, G. R. (2022). Potent cross-reactive antibodies following Omicron breakthrough in vaccinees. CELL, 185(12), 2116-+. doi:10.1016/j.cell.2022.05.014DOI: 10.1016/j.cell.2022.05.014
David, A., Parkinson, N., Peacock, T. P., Pairo-Castineira, E., Khanna, T., Cobat, A., . . . Sternberg, M. J. E. (2022). A common TMPRSS2 variant has a protective effect against severe COVID-19. Current Research in Translational Medicine, 70(2), 103333. doi:10.1016/j.retram.2022.103333DOI: 10.1016/j.retram.2022.103333
Relph, K. A., Russell, C. D., Fairfield, C. J., Turtle, L., de Silva, T. I., Siggins, M. K., . . . Young, P. (2022). Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission. Open Forum Infectious Diseases, 9(5). doi:10.1093/ofid/ofac179DOI: 10.1093/ofid/ofac179
Swann, O. V., Pollock, L., Holden, K. A., Munro, A. P. S., Bennett, A., Williams, T. C., . . . Investigators, I. (2022). Comparison of UK paediatric SARS-CoV-2 admissions across the first and second pandemic waves. PEDIATRIC RESEARCH. doi:10.1038/s41390-022-02052-5DOI: 10.1038/s41390-022-02052-5
SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses (Journal article)
Swets, M. C., Russell, C. D., Harrison, E. M., Docherty, A. B., Lone, N., Girvan, M., . . . Baillie, J. K. (2022). SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses. LANCET, 399(10334), 1463-1464. doi:10.1016/S0140-6736(22)00383-XDOI: 10.1016/S0140-6736(22)00383-X
Asiimwe, I. G., & Pirmohamed, M. (n.d.). Ethnic Diversity and Warfarin Pharmacogenomics. Frontiers in Pharmacology, 13. doi:10.3389/fphar.2022.866058DOI: 10.3389/fphar.2022.866058
Rosadas, C., Khan, M., Parker, E., Marchesin, F., Katsanovskaja, K., Sureda-Vives, M., . . . Tedder, R. S. (2022). Detection and quantification of antibody to SARS CoV 2 receptor binding domain provides enhanced sensitivity, specificity and utility. JOURNAL OF VIROLOGICAL METHODS, 302. doi:10.1016/j.jviromet.2022.114475DOI: 10.1016/j.jviromet.2022.114475
Narhi, F., Moonesinghe, S. R., Shenkin, S. D., Drake, T. M., Mulholland, R. H., Donegan, C., . . . Docherty, A. B. (2022). Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. LANCET DIGITAL HEALTH, 4(4). Retrieved from https://www.webofscience.com/
Egan, C., Turtle, L., Thorpe, M., Harrison, E. M., Semple, M. G., & Docherty, A. B. (2022). Hospital admission for symptomatic COVID-19 and impact of vaccination: analysis of linked data from the Coronavirus Clinical Information Network and the National Immunisation Management Service. ANAESTHESIA. doi:10.1111/anae.15677DOI: 10.1111/anae.15677
Cardiovascular drugs and COVID-19 clinical outcomes: a systematic review and meta-analysis of randomized controlled trials (Journal article)
Asiimwe, I., Pushpakom, S., Turner, R., Kolamunnage-Dona, R., Jorgensen, A., & Pirmohamed, M. (2022). Cardiovascular drugs and COVID-19 clinical outcomes: a systematic review and meta-analysis of randomized controlled trials. doi:10.22541/au.164431813.39836023/v1DOI: 10.22541/au.164431813.39836023/v1
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (2022). SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. Cell, 185(3), 467-484.e15. doi:10.1016/j.cell.2021.12.046DOI: 10.1016/j.cell.2021.12.046
Sullivan, M. K., Lees, J. S., Drake, T. M., Docherty, A. B., Oates, G., Hardwick, H. E., . . . Mark, P. B. (2022). Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study. NEPHROLOGY DIALYSIS TRANSPLANTATION, 37(2), 271-284. doi:10.1093/ndt/gfab303DOI: 10.1093/ndt/gfab303
Knight, S. R., Gupta, R. K., Ho, A., Pius, R., Buchan, I., Carson, G., . . . Harrison, E. M. (2022). Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. THORAX, 77(6), 606-615. doi:10.1136/thoraxjnl-2021-217629DOI: 10.1136/thoraxjnl-2021-217629
Asiimwe, I. G., Blockman, M., Cohen, K., Cupido, C., Hutchinson, C., Jacobson, B., . . . Pirmohamed, M. (2022). Stable warfarin dose prediction in sub-Saharan African patients: A machine-learning approach and external validation of a clinical dose-initiation algorithm. CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 11(1), 20-29. doi:10.1002/psp4.12740DOI: 10.1002/psp4.12740
2021
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (2021). Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. bioRxiv. doi:10.1101/2021.12.03.471045DOI: 10.1101/2021.12.03.471045
Niemi, M. E. K., Karjalainen, J., Daly, M., Ganna, A., Mehtonen, J., Cordioli, M., . . . Dopazo, X. (2021). Mapping the human genetic architecture of COVID-19. NATURE, 600(7889), 472-+. doi:10.1038/s41586-021-03767-xDOI: 10.1038/s41586-021-03767-x
Asiimwe, I. G., Pushpakom, S., Turner, R. M., Kolamunnage-Dona, R., Jorgensen, A. L., & Pirmohamed, M. (2021). Cardiovascular drugs and COVID-19 clinical outcomes: A living systematic review and meta-analysis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(12), 4534-+. doi:10.1111/bcp.14927DOI: 10.1111/bcp.14927
de, S. T. I., Liu, G., Lindsey, B. B., Dong, D., Moore, S. C., Hsu, N. S., . . . Dong, T. (2021). The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. ISCIENCE, 24(11). doi:10.1016/j.isci.2021.103353DOI: 10.1016/j.isci.2021.103353
Asiimwe, I. G., Waitt, C., Sekaggya-Wiltshire, C., Hutchinson, C., Okello, E., Zhang, E. J., . . . Pirmohamed, M. (2021). Developing and Validating a Clinical Warfarin Dose-Initiation Model for Black-African Patients in South Africa and Uganda (vol 109, pg 1564, 2021). CLINICAL PHARMACOLOGY & THERAPEUTICS, 110(5), 1402. doi:10.1002/cpt.2395DOI: 10.1002/cpt.2395
Wickenhagen, A., Sugrue, E., Lytras, S., Kuchi, S., Noerenberg, M., Turnbull, M. L., . . . Wilson, S. J. (2021). A prenylated dsRNA sensor protects against severe COVID-19. SCIENCE, 374(6567). doi:10.1126/science.abj3624DOI: 10.1126/science.abj3624
Hurst, E. A., Mellanby, R. J., Handel, I., Griffith, D. M., Rossi, A. G., Walsh, T. S., . . . Russell, C. D. (2021). Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study. BMJ OPEN, 11(10). doi:10.1136/bmjopen-2021-055435DOI: 10.1136/bmjopen-2021-055435
Asiimwe, I. G., Kiiza, D., Walimbwa, S., & Sekaggya, C. W. (2021). Genetic factors associated with tuberculosis-related clinical outcomes in HIV-infected Black-African patients: a systematic review and meta-analysis. PHARMACOGENOMICS, 22(15), 997-1017. doi:10.2217/pgs-2021-0096DOI: 10.2217/pgs-2021-0096
Sigfrid, L., Drake, T. M., Pauley, E., Jesudason, E. C., Olliaro, P., Lim, W. S., . . . Scott, J. T. (2021). Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol. LANCET REGIONAL HEALTH-EUROPE, 8. doi:10.1016/j.lanepe.2021.100186DOI: 10.1016/j.lanepe.2021.100186
Asiimwe, I. (2021, August 24). Warfarin anticoagulation in patients with cardiovascular disease in sub-Saharan Africa.
Russell, C. D., Fairfield, C. J., Drake, T. M., Turtle, L., Seaton, R. A., Wootton, D. G., . . . Ho, A. (2021). Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. LANCET MICROBE, 2(8), E354-E365. doi:10.1016/S2666-5247(21)00090-2DOI: 10.1016/S2666-5247(21)00090-2
Drake, T. M., Riad, A. M., Fairfield, C. J., Egan, C., Knight, S. R., Pius, R., . . . Semple, M. G. (2021). Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. LANCET, 398(10296), 223-237. Retrieved from https://www.webofscience.com/
Docherty, A., Mulholland, R., Lone, N. I., Cheyne, C., De Angelis, D., Diaz-Ordaz, K., . . . Semple, M. (2021). Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 773-785. doi:10.1016/S2213-2600(21)00175-2DOI: 10.1016/S2213-2600(21)00175-2
Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study. (Journal article)
Drake, T. M., Fairfield, C. J., Pius, R., Knight, S. R., Norman, L., Girvan, M., . . . ISARIC4C Investigators. (2021). Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.. The Lancet. Rheumatology, 3(7), e498-e506. doi:10.1016/s2665-9913(21)00104-1DOI: 10.1016/s2665-9913(21)00104-1
Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., . . . Khunti, K. (2021). Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort. OBESITY, 29(7), 1223-1230. doi:10.1002/oby.23178DOI: 10.1002/oby.23178
Bloom, C. I., Drake, T. M., Docherty, A. B., Lipworth, B. J., Johnston, S. L., Nguyen-Van-Tam, J. S., . . . Openshaw, P. J. M. (2021). Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19 a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. LANCET RESPIRATORY MEDICINE, 9(7), 699-711. doi:10.1016/S2213-2600(21)00013-8DOI: 10.1016/S2213-2600(21)00013-8
Leclerc, Q. J., Fuller, N. M., Keogh, R. H., Diaz-Ordaz, K., Sekula, R., Semple, M. G., . . . Knight, G. M. (2021). Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England. BMC HEALTH SERVICES RESEARCH, 21(1). doi:10.1186/s12913-021-06509-xDOI: 10.1186/s12913-021-06509-x
Asiimwe, I. G., Waitt, C., Sekaggya-Wiltshire, C., Hutchinson, C., Okello, E., Zhang, E. J., . . . Pirmohamed, M. (2021). Developing and Validating a Clinical Warfarin Dose-Initiation Model for Black-African Patients in South Africa and Uganda. CLINICAL PHARMACOLOGY & THERAPEUTICS, 109(6), 1564-1574. doi:10.1002/cpt.2128DOI: 10.1002/cpt.2128
Gupta, R. K., Harrison, E. M., Ho, A., Docherty, A. B., Knight, S. R., van Smeden, M., . . . Noursadeghi, M. (2021). Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(4), 349-359. doi:10.1016/S2213-2600(20)30559-2DOI: 10.1016/S2213-2600(20)30559-2
Warfarin dosing algorithms: A systematic review (Journal article)
Asiimwe, I. G., Zhang, E. J., Osanlou, R., Jorgensen, A. L., & Pirmohamed, M. (2021). Warfarin dosing algorithms: A systematic review. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(4), 1717-1729. doi:10.1111/bcp.14608DOI: 10.1111/bcp.14608
Sigfrid, L., Drake, T., Pauley, E., Jesudason, E., Olliaro, P., Lim, W. S., . . . ISARIC4C investigators. (2021). Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol. doi:10.1101/2021.03.18.21253888DOI: 10.1101/2021.03.18.21253888
Thwaites, R. S., Sanchez Sevilla Uruchurtu, A., Siggins, M. K., Liew, F., Russell, C. D., Moore, S. C., . . . ISARIC4C investigators. (2021). Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.. Science Immunology, 6(57). doi:10.1126/sciimmunol.abg9873DOI: 10.1126/sciimmunol.abg9873
Thomson, E. C., Rosen, L. E., Shepherd, J. G., Spreafico, R., Filipe, A. D. S., Wojcechowskyj, J. A., . . . Snell, G. (2021). Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. CELL, 184(5), 1171-+. doi:10.1016/j.cell.2021.01.037DOI: 10.1016/j.cell.2021.01.037
Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A. D., Rawlik, K., Pasko, D., . . . Baillie, J. K. (2021). Genetic mechanisms of critical illness in COVID-19. NATURE, 591(7848), 92-+. doi:10.1038/s41586-020-03065-yDOI: 10.1038/s41586-020-03065-y
Leclerc, Q., Fuller, N., Keogh, R., Diaz-Ordaz, K., Sekula, R., Semple, M., . . . CMMID COVID-19 Working Group. (2021). Importance of patient bed pathways and length of stay differences in predicting COVID-19 bed occupancy in England. doi:10.1101/2021.01.14.21249791DOI: 10.1101/2021.01.14.21249791
2020
Peng, Y., Mentzer, A. J., Liu, G., Yao, X., Yin, Z., Dong, D., . . . Investigators, I. (2020). Broad and strong memory CD4(+)and CD8(+)T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19. NATURE IMMUNOLOGY, 21(11), 1336-1345. doi:10.1038/s41590-020-0782-6DOI: 10.1038/s41590-020-0782-6
Geretti, A. M., Stockdale, A. J., Kelly, S. H., Cevik, M., Collins, S., Waters, L., . . . Semple, M. G. (2020). Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): a prospective observational study.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. doi:10.1093/cid/ciaa1605DOI: 10.1093/cid/ciaa1605
Thompson, C. P., Grayson, N. E., Paton, R. S., Bolton, J. S., Lourenco, J., Penman, B. S., . . . Simmonds, P. (2020). Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. EUROSURVEILLANCE, 25(42), 33-41. doi:10.2807/1560-7917.ES.2020.25.42.2000685DOI: 10.2807/1560-7917.ES.2020.25.42.2000685
Thwaites, R., Sevilla Uruchurtu, A. S., Siggins, M., Liew, F., Russell, C., Moore, S., . . . Openshaw, P. J. M. (2020). Elevated antiviral, myeloid and endothelial inflammatory markers in severe COVID-19. doi:10.1101/2020.10.08.20209411DOI: 10.1101/2020.10.08.20209411
Drake, T. M., Docherty, A. B., Harrison, E. M., Quint, J. K., Adamali, H., Agnew, S., . . . ISARIC4C Investigators. (2020). Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study.. Am J Respir Crit Care Med. doi:10.1164/rccm.202007-2794OCDOI: 10.1164/rccm.202007-2794OC
Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. (Journal article)
Knight, S. R., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T. M., . . . ISARIC4C investigators. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.. BMJ: British Medical Journal, 370. doi:10.1136/bmj.m3339DOI: 10.1136/bmj.m3339
Swann, O., Holden, K., Turtle, L., Pollock, L., Fairfield, C., Drake, T., . . . ISARIC Coronavirus Clinical Characterisation Consortium (ISARIC4C) Investigators. (2020). Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study. BMJ, 370. doi:10.1136/bmj.m3249DOI: 10.1136/bmj.m3249
Millar, J., Neyton, L., Seth, S., Dunning, J., Merson, L., Murthy, S., . . . ISARIC-4C Investigators. (2020). Robust, reproducible clinical patterns in hospitalised patients with COVID-19. doi:10.1101/2020.08.14.20168088DOI: 10.1101/2020.08.14.20168088
Geretti, A., Stockdale, A., Kelly, S., Villa, G., Turtle, L., Semple, M., & Sabin, C. (2020). Outcomes of COVID-19 related hospitalisation among people with HIV in the ISARIC WHO Clinical Characterisation Protocol (UK): a prospective observational study. JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 23, 13-14. Retrieved from https://www.webofscience.com/
Knight, S., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T., . . . Harrison, E. (2020). Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. doi:10.1101/2020.07.30.20165464DOI: 10.1101/2020.07.30.20165464
Asiimwe, I. G., Zhang, E. J., Osanlou, R., Krause, A., Dillon, C., Suarez-Kurtz, G., . . . Pirmohamed, M. (2020). Genetic factors influencing warfarin dose in Black-African patients: a systematic review and meta-analysis.. Clinical Pharmacology and Therapeutics, 107(6), 1420-1433. doi:10.1002/cpt.1755DOI: 10.1002/cpt.1755
2016
Asiimwe, I. G., & Rumona, D. (2016). Publication proportions for registered breast cancer trials: before and following the introduction of the ClinicalTrials.gov results database.. Research integrity and peer review, 1, 10. doi:10.1186/s41073-016-0017-4DOI: 10.1186/s41073-016-0017-4
