Photo of Dr Ed Yates

Dr Ed Yates BSc(hons) PGCert, PhD, MRSC, FHEA, FRSC

Senior Lecturer Biochemistry, Cell and Systems Biology

Research

Research Interest 1

Glycosaminoglycan structure function relationships.
Protein-sugar interactions and spectroscopic methods for their study.
Carbohydrate chemistry.
Microbial-sugar interactions and their inhibition.

Research Grants

Development of a biotechnology platform for enzymatic sulfation of industrial products based on polysaccharide sulfotransferases

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

December 2020 - December 2022

Bench Fees for Sarah Abdullah S Alsaiari (201454096)

ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)

December 2020 - November 2024

Potential anti-viral and therapeutic activities of the enzymatic degradation products of pharmaceutical polysaccharides modulated by metal ions.

DURHAM UNIVERSITY (UK)

January 2021 - September 2021

Bench Fees for Marim Alsadun (201446690)

ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)

January 2021 - January 2025

Heparan sulfate production

INTELLIHEP LTD (UK)

January 2022 - April 2022

Prodromal inhibitiond of beta-secretase by synthetic heparins

ALZHEIMERS SOCIETY (UK)

June 2016 - November 2024

An enzymatic approach to the understanding, design and formation of novel polysaccharides with potential industrial applications

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

July 2018 - January 2019

Improved functional materials for wound dressings from seaweeds

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

August 2018 - January 2019

Analysis of Mucin Interactions

UNILEVER PLC (UK)

October 2017 - December 2017

Identification and evaluation of algal sulphatransferases for enzymatic polysaccharide modifications

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

July 2017 - December 2017

Investigating the potential of non-heparin anticoagulant agents with antithrombin.

WELLCOME TRUST (UK)

June 2016 - July 2016

3-O-sulfated heparan sulfate translocation in altered membrane biology: A new strategy for early population screening and halting Alzheimer’s neurodegeneration (ArrestAD)

EUROPEAN COMMISSION

January 2017 - May 2022

Generation of oligosaccharides from branched marine glycosaminoglycan – fucosylated chondroitin sulfate

IBCARB (UK)

September 2015 - November 2015

Polysaccharide analysis

SHANDONG CHENZHONG BIOPHARMACEUTICAL CO LTD (CHINA)

November 2016 - March 2017

Characterisation of polysaccharides derived from seaweeds, along with a preliminary assessment of their potential for development of nutriceutical, healthcare and functional food and beverage products.

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

July 2015 - December 2015

New tools and resources to evaluate biological sulphation

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

October 2016 - March 2018

Bench Fees Ahmed Alzahrani

MINISTRY OF HEALTH (SAUDI ARABIA)

September 2015 - August 2016

Exploiting saccharide microarrays: towards glycomic studies of heparan sulphate-protein interactions.

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

February 2004 - January 2007

Novel semi-synthetic carbohydrates as potential therapeutics for severe malaria.

MEDICAL RESEARCH COUNCIL

March 2008 - August 2012

Carbohydrate isoelectric focusing: A new tool for the unprecedented separation of complex glycosaminoglycan structures.

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

October 2008 - September 2009

Spectroscopic Analysis of Protein-Polysaccharide Complexes

DIAMOND LIGHT SOURCE LTD (UK)

October 2010 - September 2014

Chemical intervention in heparan sulphate-dependent growth factor signalling systems using engineered heparin saccharides.

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

February 2006 - March 2009

CIC biomaGUNE studentship

CIC BIOMAGUNE (SPAIN)

January 2012 - December 2015

Spectroscopic tools for improved protein secondary structure analysis in protein-heparan sulfate complexes

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

July 2006 - October 2007

Interaction of heparan sulfate with the protease beta-secretase: a novel mechanism for regulation of APP processing.

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

July 2004 - December 2007

Chemically modified low molecular weight heparins as potent disruptors of rosetting in severe malaria

WELLCOME TRUST (UK)

October 2010 - September 2011

Molecular function in post-genome biology (MOLFUN).

EUROPEAN COMMISSION

October 2006 - September 2010

Highly sensitive, rapid and high throughput sequecen analysis of glycosaminoglycans

WELLCOME TRUST (UK)

August 2007 - January 2010

Evaluation of optimised heparins as novel therapeutics for alzheimers disease.

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

May 2006 - August 2007

University of Liverpool Institutional Discipline Bridging.

MEDICAL RESEARCH COUNCIL

October 2003 - October 2006

Structures of signalling and inhibitory complexes

ROYAL SOCIETY (CHARITABLE)

April 2008 - March 2010

CASE: Detecting structural changes in protein:polysaccharide complexes: an enabling technology

M I ENGINEERING (UK)

January 2011 - December 2014

Compatibility rules for glycosaminoglycan-amyloid interactions

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

May 2014 - April 2017

Research Collaborations

Marcelo Lima and Helena Nader

External: University of São Paulo

Dr Robert Lauder

External: The University of Lancaster

to conduct solution conformation and spectroscopic studies of macromolecules

DR J Shute

External: The University of Portsmouth

exploring the potential of modified heparin polysaccharides to promote DNase activity in cystic fibrosis patients

Dr J Smalley

Internal

analysis of LPS carbohydrates

Prof R Nichols

Internal

spectroscopic investigations of protein sugar interactions

Dr M Horsburgh

Internal

carbohydrate interactions with Staph aureus bacteria and role in adhesion and infection

Drs M Guerrini, A.Naggi and G.Torri

External: Ronzoni Institute for Chemical and Biochemical Research, Milan

NMR structural studies of poly- and oligosaccharides and their conformation and interactions with cations

Dr M Goldner

External: University of Laval, Quebec

Relationship between environmental conditions and attachment of B fragilis to ECM components

Prof DG Fernig

Internal

spectroscopic studies of protein-sugar interactions

nanoparticles

Dr EO Ferreira and Prof R Domingues

External: Federal University of Rio de Janeiro (UFRJ)

Investigating the interaction of anaerobic pathogenic bacteria (esp B fragilis, C dificile) with components of the host extracellular matrix and the effect of environmental pH and Eh