2024
Morales-Camilo, N., Liu, J., Ramírez, M. J., Canales-Salgado, P., Alegría, J. J., Liu, X., . . . Bertocchi, C. (2024). Alternative molecular mechanisms for force transmission at adherens junctions via β-catenin-vinculin interaction.. Nature communications, 15(1), 5608. doi:10.1038/s41467-024-49850-5DOI: 10.1038/s41467-024-49850-5
Camp, D., Venkatesh, B., Solianova, V., Varela, L., Goult, B. T., & Tanentzapf, G. (2024). The actin binding sites of talin have both distinct and complementary roles in cell-ECM adhesion.. PLoS genetics, 20(4), e1011224. doi:10.1371/journal.pgen.1011224DOI: 10.1371/journal.pgen.1011224
Ball, N. J., Barnett, S. F. H., & Goult, B. T. (2024). Mechanically operated signalling scaffolds.. Biochemical Society transactions, BST20221194. doi:10.1042/bst20221194DOI: 10.1042/bst20221194
Kang, M., Otani, Y., Guo, Y., Yan, J., Goult, B. T., & Howe, A. K. (2024). The focal adhesion protein talin is a mechanically gated A-kinase anchoring protein.. Proceedings of the National Academy of Sciences of the United States of America, 121(13), e2314947121. doi:10.1073/pnas.2314947121DOI: 10.1073/pnas.2314947121
Guo, Y., Yan, J., & Goult, B. T. (2024). Mechanotransduction through protein stretching.. Current opinion in cell biology, 87, 102327. doi:10.1016/j.ceb.2024.102327DOI: 10.1016/j.ceb.2024.102327
2023
Newman, D., Young, L. E., Waring, T., Brown, L., Wolanska, K. I., MacDonald, E., . . . Zech, T. (2023). 3D matrix adhesion feedback controls nuclear force coupling to drive invasive cell migration.. Cell reports, 42(12), 113554. doi:10.1016/j.celrep.2023.113554DOI: 10.1016/j.celrep.2023.113554
Honasoge, K. S., Karagöz, Z., Goult, B. T., Wolfenson, H., LaPointe, V. L. S., & Carlier, A. (2023). Force-dependent focal adhesion assembly and disassembly: A computational study.. PLoS computational biology, 19(10), e1011500. doi:10.1371/journal.pcbi.1011500DOI: 10.1371/journal.pcbi.1011500
Doolan, J. A., Alesbrook, L. S., Baker, K., Brown, I. R., Williams, G. T., Hilton, K. L. F., . . . Goult, B. T. (2023). Next-generation protein-based materials capture and preserve projectiles from supersonic impacts.. Nature nanotechnology, 18(9), 1060-1066. doi:10.1038/s41565-023-01431-1DOI: 10.1038/s41565-023-01431-1
Davis-Lunn, M., Goult, B. T., & Andrews, M. R. (2023). Clutching at Guidance Cues: The Integrin-FAK Axis Steers Axon Outgrowth.. Biology, 12(7), 954. doi:10.3390/biology12070954DOI: 10.3390/biology12070954
Li, X., Goult, B. T., Ballestrem, C., & Zacharchenko, T. (2023). The structural basis of the talin-KANK1 interaction that coordinates the actin and microtubule cytoskeletons at focal adhesions.. Open biology, 13(6), 230058. doi:10.1098/rsob.230058DOI: 10.1098/rsob.230058
Gallego-Paez, L. M., Edwards, W. J. S., Chanduri, M., Guo, Y., Koorman, T., Lee, C. -Y., . . . Goult, B. T. (2023). TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity.. The Journal of cell biology, 222(5), e202209010. doi:10.1083/jcb.202209010DOI: 10.1083/jcb.202209010
Popović, A., Miihkinen, M., Ghimire, S., Saup, R., Grönloh, M. L. B., Ball, N. J., . . . Jacquemet, G. (2023). Myosin-X recruits lamellipodin to filopodia tips.. Journal of cell science, 136(5), jcs260574. doi:10.1242/jcs.260574DOI: 10.1242/jcs.260574
Kostourou, V., Goult, B. T., & Ambriović-Ristov, A. (2023). Editorial: Integrin adhesion receptors in health and disease.. Frontiers in cell and developmental biology, 11, 1149920. doi:10.3389/fcell.2023.1149920DOI: 10.3389/fcell.2023.1149920
2022
Azizi, L., Varela, L., Turkki, P., Mykuliak, V. V., Korpela, S., Ihalainen, T. O., . . . Goult, B. T. (2022). Talin variant P229S compromises integrin activation and associates with multifaceted clinical symptoms.. Human molecular genetics, 31(24), 4159-4172. doi:10.1093/hmg/ddac163DOI: 10.1093/hmg/ddac163
Barnett, S. F. H., & Goult, B. T. (2022). The MeshCODE to scale-visualising synaptic binary information.. Frontiers in cellular neuroscience, 16, 1014629. doi:10.3389/fncel.2022.1014629DOI: 10.3389/fncel.2022.1014629
Goult, B. T., von Essen, M., & Hytönen, V. P. (2022). The mechanical cell - the role of force dependencies in synchronising protein interaction networks.. Journal of cell science, 135(22), jcs259769. doi:10.1242/jcs.259769DOI: 10.1242/jcs.259769
Doolan, J. A., Williams, G. T., Hilton, K. L. F., Chaudhari, R., Fossey, J. S., Goult, B. T., & Hiscock, J. R. (2022). Advancements in antimicrobial nanoscale materials and self-assembling systems.. Chemical Society reviews, 51(20), 8696-8755. doi:10.1039/d1cs00915jDOI: 10.1039/d1cs00915j
Wen, L., Lyu, Q., Ley, K., & Goult, B. T. (2022). Structural Basis of β2 Integrin Inside-Out Activation.. Cells, 11(19), 3039. doi:10.3390/cells11193039DOI: 10.3390/cells11193039
2021
Goult, B. T., Brown, N. H., & Schwartz, M. A. (2021). Talin in mechanotransduction and mechanomemory at a glance.. Journal of cell science, 134(20), jcs258749. doi:10.1242/jcs.258749DOI: 10.1242/jcs.258749
Wang, Y., Yao, M., Baker, K. B., Gough, R. E., Le, S., Goult, B. T., & Yan, J. (2021). Force-Dependent Interactions between Talin and Full-Length Vinculin.. Journal of the American Chemical Society, 143(36), 14726-14737. doi:10.1021/jacs.1c06223DOI: 10.1021/jacs.1c06223
Miihkinen, M., Grönloh, M. L. B., Popović, A., Vihinen, H., Jokitalo, E., Goult, B. T., . . . Jacquemet, G. (2021). Myosin-X and talin modulate integrin activity at filopodia tips.. Cell reports, 36(11), 109716. doi:10.1016/j.celrep.2021.109716DOI: 10.1016/j.celrep.2021.109716
Cowell, A. R., Jacquemet, G., Singh, A. K., Varela, L., Nylund, A. S., Ammon, Y. -C., . . . Goult, B. T. (2021). Talin rod domain-containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation.. The Journal of cell biology, 220(9), e202005214. doi:10.1083/jcb.202005214DOI: 10.1083/jcb.202005214
Gough, R. E., Jones, M. C., Zacharchenko, T., Le, S., Yu, M., Jacquemet, G., . . . Goult, B. T. (2021). Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1.. The Journal of biological chemistry, 297(1), 100837. doi:10.1016/j.jbc.2021.100837DOI: 10.1016/j.jbc.2021.100837
Han, S. J., Azarova, E. V., Whitewood, A. J., Bachir, A., Guttierrez, E., Groisman, A., . . . Danuser, G. (2021). Pre-complexation of talin and vinculin without tension is required for efficient nascent adhesion maturation.. eLife, 10, e66151. doi:10.7554/elife.66151DOI: 10.7554/elife.66151
Goult, B. T. (2021). The Mechanical Basis of Memory - the MeshCODE Theory.. Frontiers in molecular neuroscience, 14, 592951. doi:10.3389/fnmol.2021.592951DOI: 10.3389/fnmol.2021.592951
Azizi, L., Cowell, A. R., Mykuliak, V. V., Goult, B. T., Turkki, P., & Hytönen, V. P. (2021). Cancer associated talin point mutations disorganise cell adhesion and migration.. Scientific reports, 11(1), 347. doi:10.1038/s41598-020-77911-4DOI: 10.1038/s41598-020-77911-4
Biochemical Characterization of the Integrin Interactome. (Journal article)
Khan, R. B., Varela, L., Cowell, A. R., & Goult, B. T. (2021). Biochemical Characterization of the Integrin Interactome.. Methods in molecular biology (Clifton, N.J.), 2217, 115-147. doi:10.1007/978-1-0716-0962-0_9DOI: 10.1007/978-1-0716-0962-0_9
2020
2019
Khan, R. B., & Goult, B. T. (2019). Adhesions Assemble!-Autoinhibition as a Major Regulatory Mechanism of Integrin-Mediated Adhesion.. Frontiers in molecular biosciences, 6, 144. doi:10.3389/fmolb.2019.00144DOI: 10.3389/fmolb.2019.00144
High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained. (Journal article)
Bryce, N. S., Failes, T. W., Stehn, J. R., Baker, K., Zahler, S., Arzhaeva, Y., . . . Lock, J. G. (2019). High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained.. Cell systems, 9(5), 496-507.e5. doi:10.1016/j.cels.2019.09.002DOI: 10.1016/j.cels.2019.09.002
Wang, Y., Yan, J., & Goult, B. T. (2019). Force-Dependent Binding Constants.. Biochemistry, 58(47), 4696-4709. doi:10.1021/acs.biochem.9b00453DOI: 10.1021/acs.biochem.9b00453
Yu, M., Le, S., Ammon, Y. -C., Goult, B. T., Akhmanova, A., & Yan, J. (2019). Force-Dependent Regulation of Talin-KANK1 Complex at Focal Adhesions.. Nano letters, 19(9), 5982-5990. doi:10.1021/acs.nanolett.9b01732DOI: 10.1021/acs.nanolett.9b01732
Michael, M., Begum, R., Chan, G. K., Whitewood, A. J., Matthews, D. R., Goult, B. T., . . . Parsons, M. (2019). Kindlin-1 Regulates Epidermal Growth Factor Receptor Signaling.. The Journal of investigative dermatology, 139(2), 369-379. doi:10.1016/j.jid.2018.08.020DOI: 10.1016/j.jid.2018.08.020
Calcium-mediated Protein Folding and Stabilization of Salmonella Biofilm-associated Protein A. (Journal article)
Guttula, D., Yao, M., Baker, K., Yang, L., Goult, B. T., Doyle, P. S., & Yan, J. (2019). Calcium-mediated Protein Folding and Stabilization of Salmonella Biofilm-associated Protein A.. Journal of molecular biology, 431(2), 433-443. doi:10.1016/j.jmb.2018.11.014DOI: 10.1016/j.jmb.2018.11.014
2018
Direct binding of Talin to Rap1 is required for cell-ECM adhesion in <i>Drosophila</i>. (Journal article)
Camp, D., Haage, A., Solianova, V., Castle, W. M., Xu, Q. A., Lostchuck, E., . . . Tanentzapf, G. (2018). Direct binding of Talin to Rap1 is required for cell-ECM adhesion in <i>Drosophila</i>.. Journal of cell science, 131(24), jcs225144. doi:10.1242/jcs.225144DOI: 10.1242/jcs.225144
Haage, A., Goodwin, K., Whitewood, A., Camp, D., Bogutz, A., Turner, C. T., . . . Tanentzapf, G. (2018). Talin Autoinhibition Regulates Cell-ECM Adhesion Dynamics and Wound Healing In Vivo.. Cell reports, 25(9), 2401-2416.e5. doi:10.1016/j.celrep.2018.10.098DOI: 10.1016/j.celrep.2018.10.098
Goult, B. T., Yan, J., & Schwartz, M. A. (2018). Talin as a mechanosensitive signaling hub.. The Journal of cell biology, 217(11), 3776-3784. doi:10.1083/jcb.201808061DOI: 10.1083/jcb.201808061
Lagarrigue, F., Gingras, A. R., Paul, D. S., Valadez, A. J., Cuevas, M. N., Sun, H., . . . Ginsberg, M. H. (2018). Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation.. Blood advances, 2(18), 2358-2368. doi:10.1182/bloodadvances.2018020487DOI: 10.1182/bloodadvances.2018020487
ProLIF - quantitative integrin protein-protein interactions and synergistic membrane effects on proteoliposomes. (Journal article)
De Franceschi, N., Miihkinen, M., Hamidi, H., Alanko, J., Mai, A., Picas, L., . . . Ivaska, J. (2018). ProLIF - quantitative integrin protein-protein interactions and synergistic membrane effects on proteoliposomes.. Journal of cell science, 132(4), jcs214270. doi:10.1242/jcs.214270DOI: 10.1242/jcs.214270
Gough, R. E., & Goult, B. T. (2018). The tale of two talins - two isoforms to fine-tune integrin signalling.. FEBS letters, 592(12), 2108-2125. doi:10.1002/1873-3468.13081DOI: 10.1002/1873-3468.13081
A Novel Mechanism for Calmodulin-Dependent Inactivation of Transient Receptor Potential Vanilloid 6. (Journal article)
Bate, N., Caves, R. E., Skinner, S. P., Goult, B. T., Basran, J., Mitcheson, J. S., & Vuister, G. W. (2018). A Novel Mechanism for Calmodulin-Dependent Inactivation of Transient Receptor Potential Vanilloid 6.. Biochemistry, 57(18), 2611-2622. doi:10.1021/acs.biochem.7b01286DOI: 10.1021/acs.biochem.7b01286
The Structural Basis of Calcium-Dependent Inactivation of the Transient Receptor Potential Vanilloid 5 Channel. (Journal article)
Bokhovchuk, F. M., Bate, N., Kovalevskaya, N. V., Goult, B. T., Spronk, C. A. E. M., & Vuister, G. W. (2018). The Structural Basis of Calcium-Dependent Inactivation of the Transient Receptor Potential Vanilloid 5 Channel.. Biochemistry, 57(18), 2623-2635. doi:10.1021/acs.biochem.7b01287DOI: 10.1021/acs.biochem.7b01287
Whitewood, A. J., Singh, A. K., Brown, D. G., & Goult, B. T. (2018). Chlamydial virulence factor TarP mimics talin to disrupt the talin-vinculin complex.. FEBS letters, 592(10), 1751-1760. doi:10.1002/1873-3468.13074DOI: 10.1002/1873-3468.13074
2017
ProLIF: a quantitative assay for investigating integrin cytoplasmic protein interactions and synergistic membrane effects on proteoliposomes (Preprint)
DOI: 10.1101/209262
Investigation of the Filamin A-Dependent Mechanisms of Tissue Factor Incorporation into Microvesicles. (Journal article)
Collier, M. E. W., Ettelaie, C., Goult, B. T., Maraveyas, A., & Goodall, A. H. (2017). Investigation of the Filamin A-Dependent Mechanisms of Tissue Factor Incorporation into Microvesicles.. Thrombosis and haemostasis, 117(11), 2034-2044. doi:10.1160/th17-01-0009DOI: 10.1160/th17-01-0009
2016
Talin2-mediated traction force drives matrix degradation and cell invasion. (Journal article)
Qi, L., Jafari, N., Li, X., Chen, Z., Li, L., Hytönen, V. P., . . . Huang, C. (2016). Talin2-mediated traction force drives matrix degradation and cell invasion.. Journal of cell science, 129(19), 3661-3674. doi:10.1242/jcs.185959DOI: 10.1242/jcs.185959
Kumar, A., Ouyang, M., Van den Dries, K., McGhee, E. J., Tanaka, K., Anderson, M. D., . . . Schwartz, M. A. (2016). Correction: Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity.. The Journal of cell biology, 214(2), 231. doi:10.1083/jcb.20151001207062016cDOI: 10.1083/jcb.20151001207062016c
Bouchet, B. P., Gough, R. E., Ammon, Y. -C., van de Willige, D., Post, H., Jacquemet, G., . . . Akhmanova, A. (2016). Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions.. eLife, 5, e18124. doi:10.7554/elife.18124DOI: 10.7554/elife.18124
Yao, M., Goult, B. T., Klapholz, B., Hu, X., Toseland, C. P., Guo, Y., . . . Yan, J. (2016). The mechanical response of talin.. Nature communications, 7, 11966. doi:10.1038/ncomms11966DOI: 10.1038/ncomms11966
LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex (Journal article)
Zacharchenko, T., Qian, X., Goult, B. T., Jethwa, D., Almeida, T. B., Ballestrem, C., . . . Barsukov, I. L. (2016). LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex. Structure, 24(7), 1130-1141. doi:10.1016/j.str.2016.04.016DOI: 10.1016/j.str.2016.04.016
Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions (Preprint)
DOI: 10.1101/055210
Kumar, A., Ouyang, M., Van den Dries, K., McGhee, E. J., Tanaka, K., Anderson, M. D., . . . Schwartz, M. A. (2016). Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity.. The Journal of cell biology, 213(3), 371-383. doi:10.1083/jcb.201510012DOI: 10.1083/jcb.201510012
Mechano-Sensitive Interaction between Talin and Full-Length Vinculin (Journal article)
Wang, Y., Goult, B. T., Yao, M., & Yan, J. (2016). Mechano-Sensitive Interaction between Talin and Full-Length Vinculin. Biophysical Journal, 110(3), 23a. doi:10.1016/j.bpj.2015.11.187DOI: 10.1016/j.bpj.2015.11.187
The Mechanical Properties of Talin Rod Domain (Journal article)
Yao, M., Goult, B. T., Sheetz, M. P., & Yan, J. (2016). The Mechanical Properties of Talin Rod Domain. Biophysical Journal, 110(3), 620a-621a. doi:10.1016/j.bpj.2015.11.3329DOI: 10.1016/j.bpj.2015.11.3329
2015
Villari, G., Jayo, A., Zanet, J., Fitch, B., Serrels, B., Frame, M., . . . Parsons, M. (2015). A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration.. Journal of cell science, 128(24), 4601-4614. doi:10.1242/jcs.175760DOI: 10.1242/jcs.175760
Atherton, P., Stutchbury, B., Wang, D. -Y., Jethwa, D., Tsang, R., Meiler-Rodriguez, E., . . . Ballestrem, C. (2015). Vinculin controls talin engagement with the actomyosin machinery.. Nature communications, 6. doi:10.1038/ncomms10038DOI: 10.1038/ncomms10038
Yan, J., Yao, M., Goult, B. T., & Sheetz, M. P. (2015). Talin Dependent Mechanosensitivity of Cell Focal Adhesions.. Cellular and molecular bioengineering, 8(1), 151-159. doi:10.1007/s12195-014-0364-5DOI: 10.1007/s12195-014-0364-5
Skinner, S. P., Goult, B. T., Fogh, R. H., Boucher, W., Stevens, T. J., Laue, E. D., & Vuister, G. W. (2015). Structure calculation, refinement and validation using CcpNmr Analysis.. Acta crystallographica. Section D, Biological crystallography, 71(Pt 1), 154-161. doi:10.1107/s1399004714026662DOI: 10.1107/s1399004714026662
2014
Ellis, S. J., Lostchuck, E., Goult, B. T., Bouaouina, M., Fairchild, M. J., López-Ceballos, P., . . . Tanentzapf, G. (2014). The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering.. PLoS genetics, 10(11), e1004756. doi:10.1371/journal.pgen.1004756DOI: 10.1371/journal.pgen.1004756
Yao, M., Goult, B. T., Chen, H., Cong, P., Sheetz, M. P., & Yan, J. (2014). Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation.. Scientific reports, 4, 4610. doi:10.1038/srep04610DOI: 10.1038/srep04610
Evans, S. E., Goult, B. T., Fairall, L., Jamieson, A. G., Ko Ferrigno, P., Ford, R., . . . Wagner, S. D. (2014). The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain.. PloS one, 9(3), e90889. doi:10.1371/journal.pone.0090889DOI: 10.1371/journal.pone.0090889
2013
Dhani, D. K., Goult, B. T., George, G. M., Rogerson, D. T., Bitton, D. A., Miller, C. J., . . . Tanaka, K. (2013). Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3(Alp6).. Molecular biology of the cell, 24(21), 3337-3349. doi:10.1091/mbc.e13-05-0253DOI: 10.1091/mbc.e13-05-0253
Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation. (Journal article)
Goult, B. T., Xu, X. -P., Gingras, A. R., Swift, M., Patel, B., Bate, N., . . . Hanein, D. (2013). Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation.. Journal of structural biology, 184(1), 21-32. doi:10.1016/j.jsb.2013.05.014DOI: 10.1016/j.jsb.2013.05.014
Ellis, S. J., Goult, B. T., Fairchild, M. J., Harris, N. J., Long, J., Lobo, P., . . . Tanentzapf, G. (2013). Talin autoinhibition is required for morphogenesis.. Current biology : CB, 23(18), 1825-1833. doi:10.1016/j.cub.2013.07.054DOI: 10.1016/j.cub.2013.07.054
Watkins, R. J., Patil, R., Goult, B. T., Thomas, M. G., Gottlob, I., & Shackleton, S. (2013). A novel interaction between FRMD7 and CASK: evidence for a causal role in idiopathic infantile nystagmus.. Human molecular genetics, 22(10), 2105-2118. doi:10.1093/hmg/ddt060DOI: 10.1093/hmg/ddt060
Goult, B. T., Zacharchenko, T., Bate, N., Tsang, R., Hey, F., Gingras, A. R., . . . Barsukov, I. L. (2013). RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.. The Journal of biological chemistry, 288(12), 8238-8249. doi:10.1074/jbc.m112.438119DOI: 10.1074/jbc.m112.438119
2012
Banno, A., Goult, B. T., Lee, H., Bate, N., Critchley, D. R., & Ginsberg, M. H. (2012). Subcellular localization of talin is regulated by inter-domain interactions.. The Journal of biological chemistry, 287(17), 13799-13812. doi:10.1074/jbc.m112.341214DOI: 10.1074/jbc.m112.341214
Bate, N., Gingras, A. R., Bachir, A., Horwitz, R., Ye, F., Patel, B., . . . Critchley, D. R. (2012). Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics.. PloS one, 7(4), e34461. doi:10.1371/journal.pone.0034461DOI: 10.1371/journal.pone.0034461
Phelan, M. M., Goult, B. T., Clayton, J. C., Hautbergue, G. M., Wilson, S. A., & Lian, L. -Y. (2012). The structure and selectivity of the SR protein SRSF2 RRM domain with RNA.. Nucleic acids research, 40(7), 3232-3244. doi:10.1093/nar/gkr1164DOI: 10.1093/nar/gkr1164
Bouaouina, M., Goult, B. T., Huet-Calderwood, C., Bate, N., Brahme, N. N., Barsukov, I. L., . . . Calderwood, D. A. (2012). A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation.. The Journal of biological chemistry, 287(10), 6979-6990. doi:10.1074/jbc.m111.330845DOI: 10.1074/jbc.m111.330845
2011
Calkin, A. C., Goult, B. T., Zhang, L., Fairall, L., Hong, C., Schwabe, J. W. R., & Tontonoz, P. (2011). FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors.. Proceedings of the National Academy of Sciences of the United States of America, 108(50), 20107-20112. doi:10.1073/pnas.1111589108DOI: 10.1073/pnas.1111589108
Zhang, L., Fairall, L., Goult, B. T., Calkin, A. C., Hong, C., Millard, C. J., . . . Schwabe, J. W. R. (2011). The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.. Genes & development, 25(12), 1262-1274. doi:10.1101/gad.2056211DOI: 10.1101/gad.2056211
The (1)H, (13)C and (15)N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing (Journal article)
Clayton, J. C., Phelan, M., Goult, B. T., Hautbergue, G. M., Wilson, S. A., & Lian, L. Y. (2011). The (1)H, (13)C and (15)N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing. BIOMOLECULAR NMR ASSIGNMENTS, 5, 7-10.
The 1H, 13C and 15N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing. (Journal article)
Clayton, J. C., Phelan, M., Goult, B. T., Hautbergue, G. M., Wilson, S. A., & Lian, L. -Y. (2011). The 1H, 13C and 15N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing.. Biomolecular NMR assignments, 5(1), 7-10. doi:10.1007/s12104-010-9254-5DOI: 10.1007/s12104-010-9254-5
Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery. (Journal article)
Oberoi, J., Fairall, L., Fairall, L., Watson, P. J., Yang, J. -C., Czimmerer, Z., . . . Schwabe, J. W. R. (2011). Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.. Nature structural & molecular biology, 18(2), 177-184. doi:10.1038/nsmb.1983DOI: 10.1038/nsmb.1983
2010
Elliott, P. R., Goult, B. T., Kopp, P. M., Bate, N., Grossmann, J. G., Roberts, G. C. K., . . . Barsukov, I. L. (2010). The Structure of the talin head reveals a novel extended conformation of the FERM domain.. Structure (London, England : 1993), 18(10), 1289-1299. doi:10.1016/j.str.2010.07.011DOI: 10.1016/j.str.2010.07.011
Kalli, A. C., Wegener, K. L., Goult, B. T., Anthis, N. J., Campbell, I. D., & Sansom, M. S. P. (2010). The structure of the talin/integrin complex at a lipid bilayer: an NMR and MD simulation study.. Structure (London, England : 1993), 18(10), 1280-1288. doi:10.1016/j.str.2010.07.012DOI: 10.1016/j.str.2010.07.012
Gingras, A. R., Bate, N., Goult, B. T., Patel, B., Kopp, P. M., Emsley, J., . . . Critchley, D. R. (2010). Central region of talin has a unique fold that binds vinculin and actin.. The Journal of biological chemistry, 285(38), 29577-29587. doi:10.1074/jbc.m109.095455DOI: 10.1074/jbc.m109.095455
Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1. (Journal article)
Kopp, P. M., Bate, N., Hansen, T. M., Brindle, N. P. J., Praekelt, U., Debrand, E., . . . Monkley, S. J. (2010). Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.. European journal of cell biology, 89(9), 661-673. doi:10.1016/j.ejcb.2010.05.003DOI: 10.1016/j.ejcb.2010.05.003
Goult, B. T., Gingras, A. R., Bate, N., Barsukov, I. L., Critchley, D. R., & Roberts, G. C. K. (2010). The domain structure of talin: residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site.. FEBS letters, 584(11), 2237-2241. doi:10.1016/j.febslet.2010.04.028DOI: 10.1016/j.febslet.2010.04.028
Goult, B. T., Bouaouina, M., Elliott, P. R., Bate, N., Patel, B., Gingras, A. R., . . . Barsukov, I. L. (2010). Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.. The EMBO journal, 29(6), 1069-1080. doi:10.1038/emboj.2010.4DOI: 10.1038/emboj.2010.4
2009
The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation. (Journal article)
Goult, B. T., Bouaouina, M., Harburger, D. S., Bate, N., Patel, B., Anthis, N. J., . . . Critchley, D. R. (2009). The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation.. Journal of molecular biology, 394(5), 944-956. doi:10.1016/j.jmb.2009.09.061DOI: 10.1016/j.jmb.2009.09.061
The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. (Journal article)
Anthis, N. J., Wegener, K. L., Ye, F., Kim, C., Goult, B. T., Lowe, E. D., . . . Campbell, I. D. (2009). The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.. The EMBO journal, 28(22), 3623-3632. doi:10.1038/emboj.2009.287DOI: 10.1038/emboj.2009.287
Goult, B. T., Bate, N., Anthis, N. J., Wegener, K. L., Gingras, A. R., Patel, B., . . . Critchley, D. R. (2009). The structure of an interdomain complex that regulates talin activity.. The Journal of biological chemistry, 284(22), 15097-15106. doi:10.1074/jbc.m900078200DOI: 10.1074/jbc.m900078200
Gingras, A. R., Ziegler, W. H., Bobkov, A. A., Joyce, M. G., Fasci, D., Himmel, M., . . . Critchley, D. R. (2009). Structural determinants of integrin binding to the talin rod.. The Journal of biological chemistry, 284(13), 8866-8876. doi:10.1074/jbc.m805937200DOI: 10.1074/jbc.m805937200
2008
Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling. (Journal article)
Srivastava, J., Barreiro, G., Groscurth, S., Gingras, A. R., Goult, B. T., Critchley, D. R., . . . Barber, D. L. (2008). Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling.. Proceedings of the National Academy of Sciences of the United States of America, 105(38), 14436-14441. doi:10.1073/pnas.0805163105DOI: 10.1073/pnas.0805163105
NMR assignment of the C-terminal actin-binding domain of talin. (Journal article)
Goult, B. T., Gingras, A. R., Bate, N., Roberts, G. C. K., Critchley, D. R., & Barsukov, I. L. (2008). NMR assignment of the C-terminal actin-binding domain of talin.. Biomolecular NMR assignments, 2(1), 17-19. doi:10.1007/s12104-007-9073-5DOI: 10.1007/s12104-007-9073-5
The structure of the C-terminal actin-binding domain of talin (Journal article)
Gingras, A. R., Bate, N., Goult, B. T., Hazelwood, L., Canestrelli, I., Grossmann, J. G., . . . Critchley, D. R. (2008). The structure of the C-terminal actin-binding domain of talin. The EMBO Journal, 27(2), 458-469. doi:10.1038/sj.emboj.7601965DOI: 10.1038/sj.emboj.7601965
Gingras, A. R., Bate, N., Goult, B. T., Hazelwood, L., Canestrelli, I., Grossmann, J. G., . . . Critchley, D. R. (2008). The structure of the C-terminal actin-binding domain of talin.. The EMBO journal, 27(2), 458-469. doi:10.1038/sj.emboj.7601965DOI: 10.1038/sj.emboj.7601965
2007
Small-angle X-ray scattering and NMR studies of the conformation of the PDZ region of SAP97 and its interactions with Kir2.1 (Journal article)
Goult, B. T., Rapley, J. D., Dart, C., Kitmitto, A., Grossmann, J. G., Leyland, M. L., & Lian, L. -Y. (2007). Small-angle X-ray scattering and NMR studies of the conformation of the PDZ region of SAP97 and its interactions with Kir2.1. BIOCHEMISTRY, 46(49), 14117-14128. doi:10.1021/bi701257zDOI: 10.1021/bi701257z
2006
Assignment of 1H, 13C, and 15N resonances for the PilP pilot protein from Neisseria meningitidis. (Journal article)
Golovanov, A. P., Balasingham, S., Tzitzilonis, C., Goult, B. T., Lian, L. -Y., Homberset, H., . . . Derrick, J. P. (2006). Assignment of 1H, 13C, and 15N resonances for the PilP pilot protein from Neisseria meningitidis.. Journal of biomolecular NMR, 36 Suppl 1, 68. doi:10.1007/s10858-006-9054-5DOI: 10.1007/s10858-006-9054-5
The solution structure of a domain from the Neisseria meningitidis lipoprotein PilP reveals a new beta-sandwich fold. (Journal article)
Golovanov, A. P., Balasingham, S., Tzitzilonis, C., Goult, B. T., Lian, L. -Y., Homberset, H., . . . Derrick, J. P. (2006). The solution structure of a domain from the Neisseria meningitidis lipoprotein PilP reveals a new beta-sandwich fold.. Journal of molecular biology, 364(2), 186-195. doi:10.1016/j.jmb.2006.08.078DOI: 10.1016/j.jmb.2006.08.078
