Selective C-H functionalisations in industrially important alkylarenes

Applications are invited for a 3.5-year PhD studentship in the research group of Dr Alexey Sergeev in the Department of Chemistry, University of Liverpool, UK, starting from October 1, 2025. 

Research project:

This PhD project will focus on designing conceptually new metal-mediated selective C-H functionalisations of arenes without directing groups. This will be achieved by exploring the unique reactivity of transition metal complexes that coordinate arenes in a rare eta-4 mode. This coordination mode bends the aromatic ring and enables the arene to undergo a range of unconventional C-H (e. g. J. Am. Chem. Soc. 2022, 144, 11564) and C-C bond activations (e. g. J. Am. Chem. Soc. 2019,141, 6048; Angew. Chem. Int. Ed. 2017, 56, 3266). These approaches have an excellent potential for the development of synthetically useful arene functionalisations. The project will involve synthetic and mechanistic studies, which will be supported by DFT computations in collaboration with our UoL colleagues.

Training:

The successful applicant will receive training in modern analytical methods for characterisation of organic and organometallic compounds (NMR, MS, XRD, GC), the synthesis of organic/organometallic compounds using Schlenk and glovebox techniques, critical discussion of research results and reaction mechanisms, as well as research report writing and presenting. There will be an opportunity to participate in a student-led research seminar committee, inter-group problem solving sessions, and presentations. The knowledge and skills acquired will provide the candidate with a solid basis for candidate’s future academic or industrial career in organic chemistry and catalysis. 

Requirements:

We are looking for highly motivated graduates with a Masters's degree in chemistry (1st/2.1 class or equivalent qualification). Excellent experimental skills and knowledge of organic chemistry are required; a background in organometallic chemistry and catalysis would be an advantage. We want all our staff and students to feel that Liverpool is an inclusive and welcoming environment that actively celebrates and encourages diversity.  We are committed to working with students to make all reasonable project adaptations including supporting those with caring responsibilities, disabilities and other person circumstances.  For example, if you have a disability you may be entitled to a Disabled Students Allowance on top of your studentship to help cover the cost of any additional support that a person studying for a doctorate might need as a result. 

We want all our staff and students to feel that Liverpool is an inclusive and welcoming environment that actively celebrates and encourages diversity.  We are committed to working with students to make all reasonable project adaptations including supporting those with caring responsibilities, disabilities and other person circumstances.  For example, if you have a disability you may be entitled to a Disabled Students Allowance on top of your studentship to help cover the cost of any additional support that a person studying for a doctorate might need as a result. 

Please ensure you include the project title and reference number CCPR149 when applying.

https://www.liverpool.ac.uk/postgraduate-research/how-to-apply/

Application details:

Applications should be made by 31 March 2025. Informal enquiries are encouraged and should be addressed to Dr Alexey Sergeev (sergeev@liverpool.ac.uk).