Investigating how tumour associated macrophages affect cancer metastasis and response to therapies
- Supervisors: Prof Ainhoa Mielgo Prof Michael Schmid
Description
Solid tumours are generally highly infiltrated by macrophages. Macrophages are heterogeneous and different populations with different and sometimes even opposite functions co-exist in tumours affecting cancer progression. Macrophages affect the response to therapies, metastasis and the immune response against cancer. Our team focuses on investigating the molecular mechanisms that regulate macrophage function in cancer in order to develop more effective therapies for hard to treat cancers such as pancreatic cancer. To investigate this, we use a variety of technologies including single cell RNA sequencing, spatial transcriptomics, flow/ mass cytometry, proteomics, imaging technologies, bioinformatics, and pre-clinical models as well as patient samples.
The project is suited to a student with at least a good B.Sc. Upper Second in Biological or Biomedical Sciences. An MSc in Cancer Biology or related topic or experience in working in a lab as a technician is desired.
Please note: Applications will be reviewed until a suitable candidate is appointed. The deadline for this project may therefore be subject to change.
Availability
Open to students worldwide
Funding information
Self-funded project
The project is open to both European/UK and International students. It is UNFUNDED and applicants are encouraged to contact the Principal Supervisor directly to discuss their application and the project.
Assistance will be given to those who are applying to international funding schemes.
The successful applicant will be expected to provide the funding for tuition fees and living expenses as well as research costs of £10,000 per year.
New self-funded applicants may be eligible for a tuition fees bursary.
Details of costs can be found on the University website: https://www.liverpool.ac.uk/study/postgraduate-research/fees-and-funding/fees-and-costs/