Exploring influenza virus evolution using state-of-the-art technology and experimental animal model

Description

History has shown that influenza viruses have the capacity to cause severe pandemics and was responsible for four pandemics between 1918 and 2009. In this context, the proposed study is focused on exploring influenza virus evolution and the barriers they face when introduced to a new host species using integrated in silico, in vitro and in vivo approaches. The student will:

1-Perform virus isolation, whole genome sequencing, and evolutionary analysis (Year 1)

2-By using 10x single cell genomics, aim to identify differences in cellular responses between different influenza strains (Year 2)

3- Conduct animal experiment in mice model to investigate the pathobiology of different influenza strains (Year3).

Guidance will be provided on research design, methodology, and career development over the project period. Regular meetings, and follow-up sessions will be held weekly. The student will have access to modern laboratories, databases, and software specific to the research project. The interdisciplinary approach combining in silico, in vitro and in vivo studies will equip the student with a competitive set of skills that is highly sought after in both academia and industry.

This is a full-time in-person position based at in the Main Liverpool Campus.

Applicants must have obtained, or anticipate achieving, a UK honours degree at 2.1 or above (or equivalent for non-UK degrees), in a relevant field. Additional info for international student can be found here https://www.liverpool.ac.uk/international/applying/entry-requirements/

To apply please send your cover letter and CV to the principal supervisor at Mahmoud.naguib@liverpool.ac.uk. This ad is until the position is filled or by latest 30.04.2025.