The system acquires high-resolution cross-sectional images in real time. Both endogenous and exogenous molecules, which absorb light in the near infrared range, can be resolved using the MSOT system. These molecules or contrast agents can be visualised and quantified throughout the whole animal.
Below are examples of videos taken using the system.
- MSOT for kidney function
MSOT imaging for kidney function in a ischaemia reperfusion injury model. Images acquired following administration of a near-infrared dye (IRDye 800). Normal accumulation of dye in the left kidney and renal pelvis (shown by white arrow) is observed while decreased signal in the injured right kidney and renal pelvis is seen (shown in green arrow).
- MSOT for liver function
Imaging a healthy liver and gallbladder following administration of indocyanine green (ICG). The liver uptake and eventual biliary accumulation of ICG can be seen.
- MSOT macrophages in a liver
Distribution of gold nano-rods labelled macrophages in a liver by MSOT
Currently active projects:
- Measurement of kidney function
- Measurement of liver function
- Measurement of tumour oxygenation
- Measurement of tumour vascularisation
- Tracking of gold nanorod labelled cells
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