Publications
2024
Plug and play virus-like particles for the generation of anti-toxin antibodies.
Edge, R. J., Marriott, A. E., Stars, E. L., Patel, R. N., Wilkinson, M. C., King, L. D. W., . . . Ainsworth, S. (2024). Plug and play virus-like particles for the generation of anti-toxin antibodies.. Toxicon: X, 23, 100204. doi:10.1016/j.toxcx.2024.100204
Progress on improving animal welfare and experiment translatability using an animal model of venom induced consumption coagulopathy
Marriott, A. E., Stars, E., Casewell, N., & Ainsworth, S. (2024). Progress on improving animal welfare and experiment translatability using an animal model of venom induced consumption coagulopathy. Toxicon, 248, 107924. doi:10.1016/j.toxicon.2024.107924
Small molecule therapeutics for neutralising venom toxins – a drug discovery approach
Albulescu, L. -O., Westhorpe, A., Marriott, A., Clare, R. H., Stars, E., Mosallam, N., . . . Casewell, N. R. (2024). Small molecule therapeutics for neutralising venom toxins – a drug discovery approach. In Toxicon Vol. 248 (pp. 107942). Elsevier BV. doi:10.1016/j.toxicon.2024.107942
Molecular dissection of cobra venom highlights heparinoids as an antidote for spitting cobra envenoming.
Du, T. Y., Hall, S. R., Chung, F., Kurdyukov, S., Crittenden, E., Patel, K., . . . Neely, G. G. (2024). Molecular dissection of cobra venom highlights heparinoids as an antidote for spitting cobra envenoming.. Science translational medicine, 16(756), eadk4802. doi:10.1126/scitranslmed.adk4802
Sequential Infection with Influenza A Virus Followed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Leads to More Severe Disease and Encephalitis in a Mouse Model of COVID-19.
Clark, J. J., Penrice-Randal, R., Sharma, P., Dong, X., Pennington, S. H., Marriott, A. E., . . . Stewart, J. P. (2024). Sequential Infection with Influenza A Virus Followed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Leads to More Severe Disease and Encephalitis in a Mouse Model of COVID-19.. Viruses, 16(6), 863. doi:10.3390/v16060863
Improving <i>in vivo</i> assays in snake venom and antivenom research: A community discussion.
Marriott, A. E., Casewell, N. R., Lilley, E., Gutiérrez, J. -M., & Ainsworth, S. (2024). Improving <i>in vivo</i> assays in snake venom and antivenom research: A community discussion.. F1000Research, 13, 192. doi:10.12688/f1000research.148223.1
African polyvalent antivenom can maintain pharmacological stability and ability to neutralise murine venom lethality for decades post-expiry: evidence for increasing antivenom shelf life to aid in alleviating chronic shortages.
Solano, G., Cunningham, S., Edge, R. J., Duran, G., Sanchez, A., Villalta, M., . . . Ainsworth, S. (2024). African polyvalent antivenom can maintain pharmacological stability and ability to neutralise murine venom lethality for decades post-expiry: evidence for increasing antivenom shelf life to aid in alleviating chronic shortages.. BMJ global health, 9(3), e014813. doi:10.1136/bmjgh-2023-014813
Combinations of the azaquinazoline anti-<i>Wolbachia</i> agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis.
Hegde, S., Marriott, A. E., Pionnier, N., Steven, A., Bulman, C., Gunderson, E., . . . Turner, J. D. (2024). Combinations of the azaquinazoline anti-<i>Wolbachia</i> agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis.. Frontiers in microbiology, 15, 1346068. doi:10.3389/fmicb.2024.1346068
Improving in vivo assays in snake venom and antivenom research: A community discussion
Marriott, A., Casewell, N., Lilley, E., Gutiérrez, J. -M., & Ainsworth, S. (2024). Improving in vivo assays in snake venom and antivenom research: A community discussion. doi:10.12688/f1000research.148223.1
2023
A dirofilariasis mouse model for heartworm preclinical research
Dirofilariasis mouse models for heartworm preclinical research
Marriott, A. E., Dagley, J. L., Hegde, S., Steven, A., Fricks, C., DiCosty, U., . . . Turner, J. D. (2023). Dirofilariasis mouse models for heartworm preclinical research. FRONTIERS IN MICROBIOLOGY, 14. doi:10.3389/fmicb.2023.1208301
2022
NKp46<SUP>+</SUP> natural killer cells develop an activated/memory-like phenotype and contribute to innate immunity against experimental filarial infection
Pionnier, N., Furlong-Silva, J., Colombo, S. A. P., Marriott, A. E. E., Chunda, V. C. C., Ndzeshang, B. L. L., . . . Turner, J. D. D. (2022). NKp46<SUP>+</SUP> natural killer cells develop an activated/memory-like phenotype and contribute to innate immunity against experimental filarial infection. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.969340
<i>Wolbachia</i> depletion blocks transmission of lymphatic filariasis by preventing chitinase-dependent parasite exsheathment
Quek, S., Cook, D. A. N., Wu, Y., Marriott, A. E., Steven, A., Johnston, K. L., . . . Taylor, M. J. (2022). <i>Wolbachia</i> depletion blocks transmission of lymphatic filariasis by preventing chitinase-dependent parasite exsheathment. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(15). doi:10.1073/pnas.2120003119
In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus
Menzies, S. K., Clare, R. H., Xie, C., Westhorpe, A., Hall, S. R., Edge, R. J., . . . Casewell, N. R. (2022). In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus. Toxicon: X, 14, 100118. doi:10.1016/j.toxcx.2022.100118
A mouse infection model and long-term lymphatic endothelium co-culture system to evaluate drugs against adult <i>Brugia malayi</i>
Marriott, A. E., Silva, J. F., Pionnier, N., Sjoberg, H., Archer, J., Steven, A., . . . Turner, J. D. (2022). A mouse infection model and long-term lymphatic endothelium co-culture system to evaluate drugs against adult <i>Brugia malayi</i>. PLOS NEGLECTED TROPICAL DISEASES, 16(6). doi:10.1371/journal.pntd.0010474
2021
Welcome to online-only production of <i>Parasitology</i> and future-proofing of the journal's academic standards
Stothard, J. R., Ainsworth, S., & Marriott, A. E. (2021). Welcome to online-only production of <i>Parasitology</i> and future-proofing of the journal's academic standards. PARASITOLOGY, 148(13), 1529-1531. doi:10.1017/S003118202100144X
Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: <i>Trichuris muris</i>, <i>Brugia malayi</i>, <i>Heligmosomoides polygyrus</i>, and <i>Schistosoma mansoni</i>
Partridge, F. A., Bataille, C. J. R., Forman, R., Marriott, A. E., Forde-Thomas, J., Haeberli, C., . . . Sattelle, D. B. (2021). Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: <i>Trichuris muris</i>, <i>Brugia malayi</i>, <i>Heligmosomoides polygyrus</i>, and <i>Schistosoma mansoni</i>. ACS INFECTIOUS DISEASES, 7(5), 1260-1274. doi:10.1021/acsinfecdis.1c00025
Tetracyclines improve experimental lymphatic filariasis pathology by disrupting interleukin-4 receptor-mediated lymphangiogenesis
Furlong-Silva, J., Cross, S. D., Marriott, A. E., Pionnier, N., Archer, J., Steven, A., . . . Turner, J. D. (2021). Tetracyclines improve experimental lymphatic filariasis pathology by disrupting interleukin-4 receptor-mediated lymphangiogenesis. JOURNAL OF CLINICAL INVESTIGATION, 131(5). doi:10.1172/JCI140853
2020
Structural requirements for dihydrobenzoxazepinone anthelmintics: actions against medically important and model parasites -<i>Trichuris muris</i>,<i>Brugia malayi</i>,<i>Heligmosomoides polygyrus</i>and<i>Schistosoma mansoni</i>
Sequential infection with influenza A virus followed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to more severe disease and encephalitis in a mouse model of COVID-19
Clark, J., Penrice-Randal, R., Sharma, P., Kipar, A., Dong, X., Pennington, S., . . . Stewart, J. (2020). Sequential infection with influenza A virus followed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to more severe disease and encephalitis in a mouse model of COVID-19. doi:10.1101/2020.10.13.334532
Eosinophil-Mediated Immune Control of Adult Filarial Nematode Infection Can Proceed in the Absence of IL-4 Receptor Signaling
Pionnier, N., Sjoberg, H., Furlong-Silva, J., Marriott, A., Halliday, A., Archer, J., . . . Turner, J. D. (2020). Eosinophil-Mediated Immune Control of Adult Filarial Nematode Infection Can Proceed in the Absence of IL-4 Receptor Signaling. JOURNAL OF IMMUNOLOGY, 205(3), 731-740. doi:10.4049/jimmunol.1901244
Novel anti-<i>Wolbachia</i> drugs, a new approach in the treatment and prevention of veterinary filariasis?
Turner, J. D., Marriott, A. E., Hong, D., O'Neill, P., Ward, S. A., & Taylor, M. J. (2020). Novel anti-<i>Wolbachia</i> drugs, a new approach in the treatment and prevention of veterinary filariasis?. VETERINARY PARASITOLOGY, 279. doi:10.1016/j.vetpar.2020.109057
2019
The reduction, refinement and replacement of animals in anti-filarial drug research
Marriott, A. (2019, September 2). The reduction, refinement and replacement of animals in anti-filarial drug research.
2018
Validation of ultrasound bioimaging to predict worm burden and treatment efficacy in preclinical filariasis drug screening models
Marriott, A. E., Sjoberg, H., Tyrer, H., Gamble, J., Murphy, E., Archer, J., . . . Turner, J. D. (2018). Validation of ultrasound bioimaging to predict worm burden and treatment efficacy in preclinical filariasis drug screening models. SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-018-24294-2
A LONG-TERM <it>BRUGIA MALAYI</it> LYMPHATIC ENDOTHELIAL CO-CULTURE SYSTEM AND ITS VALIDATION AS AND ANTI-<it>WOLBACHIA</it> DRUG ASSESSMENT MODEL
Marriott, A., Archer, J., Steven, A., Taylor, M., & Turner, J. (2018). A LONG-TERM <it>BRUGIA MALAYI</it> LYMPHATIC ENDOTHELIAL CO-CULTURE SYSTEM AND ITS VALIDATION AS AND ANTI-<it>WOLBACHIA</it> DRUG ASSESSMENT MODEL. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 99 (pp. 169-170). Retrieved from https://www.webofscience.com/
2017
APPLICATION OF ULTRASONOGRAPHY TO DETECT PERITONEAL FILARIAL DANCE SIGN IN PRECLINICAL RODENT <i>BRUGIA MALAYI</i> MACROFILARICIDAL DRUG SCREENING MODELS
Marriott, A. E., Sjoberg, H., Cook, D., Steven, A., Taylor, M. J., & Turner, J. D. (2017). APPLICATION OF ULTRASONOGRAPHY TO DETECT PERITONEAL FILARIAL DANCE SIGN IN PRECLINICAL RODENT <i>BRUGIA MALAYI</i> MACROFILARICIDAL DRUG SCREENING MODELS. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 95 (pp. 349). Retrieved from https://www.webofscience.com/